| Publications [#113193] of Harold P. Erickson
Papers Published
- DJ Leahy, I Aukhil, HP Erickson, 2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region.,
Cell, vol. 84 no. 1
(January, 1996),
pp. 155-64, ISSN 0092-8674
(last updated on 2013/05/16)
Abstract: We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. The cell-binding RGD loop is well-ordered in this structure and extends approximately 10 A away from the FN7-10 core.
Keywords: Amino Acid Sequence • Crystallography • Fibronectins • Humans • Image Processing, Computer-Assisted • Molecular Sequence Data • Oligopeptides • Protein Conformation • chemistry* • ultrastructure
|