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Publications [#113193] of Harold P. Erickson

Papers Published

  1. DJ Leahy, I Aukhil, HP Erickson, 2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region., Cell, vol. 84 no. 1 (January, 1996), pp. 155-64, ISSN 0092-8674
    (last updated on 2013/05/16)

    Abstract:
    We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. The cell-binding RGD loop is well-ordered in this structure and extends approximately 10 A away from the FN7-10 core.

    Keywords:
    Amino Acid Sequence • Crystallography • Fibronectins • Humans • Image Processing, Computer-Assisted • Molecular Sequence Data • Oligopeptides • Protein Conformation • chemistry* • ultrastructure


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