Publications [#62174] of Kam W. Leong
- Lo, H. and Kadiyala, S. and Guggino, S.E. and Leong, K.W., Poly(L-lactic acid) foams with cell seeding and controlled-release capacity,
Journal of Biomedical Materials Research, vol. 30 no. 4
pp. 475 - 484 [(SICI)1097-4636(199604)30:4<475::AID-JBM5>3.0.CO;2-M]
(last updated on 2007/04/13)
A synthetic porous 3-D structure that can mimic the architecture of actual tissues, provide sustained release of nutrients or growth factors, and serve as a template for cell seeding would be an ideal substrate for tissue engineering. Poly(1-lactic acid) foams were fabricated for this purpose, based on the principle of phase separation from homogeneous naphthalene solutions. Complex shapes could be readily fabricated, and resulting foams had relatively uniform, open cells throughout the matrix.
Foams;Cells;Porous materials;Structure (composition);Growth kinetics;Naphthalene;Thermoanalysis;Sublimation;Enzyme kinetics;