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| Publications [#62323] of Nimmi Ramanujam
Papers Published
- Changfang Zhu and Palmer, G.M. and Breslin, T.M. and Fushen Xu and Ramanujam, N., Use of a multiseparation fiber optic probe for the optical diagnosis of breast cancer,
J. Biomed. Opt. (USA), vol. 10 no. 2
(2005),
pp. 24032 - 1 [1.1897398]
(last updated on 2007/04/13)
Abstract:
We explore the effects of the illumination and collection geometry on optical spectroscopic diagnosis of breast cancer. Fluorescence and diffuse reflectance spectroscopy in the UV-visible spectral range are made with a multiseparation probe at three illumination-collection separations of 735, 980, and 1225 μm, respectively, from 13 malignant and 34 nonmalignant breast tissues. Statistical analysis is carried out on two types of data inputs: (1) the fluorescence and diffuse reflectance spectra recorded at each of the three illumination-collection separations and (2) the integrated fluorescence (at each excitation wavelength) or diffuse reflectance over the entire spectrum at all three illumination-collection separations. The results show that using the integrated fluorescence intensities recorded at a single excitation wavelength at all three illumination-collection separations can discriminate malignant from nonmalignant breast tissues with similar classification accuracy to that using spectral data measured at several excitation wavelengths with a single illumination-collection separation. These findings have significant implications with respect to the design of an optical system for breast cancer diagnosis. Examining the intensity attenuation at a single wavelength rather than spectral intensities at multiple wavelengths can significantly reduce the measurement and data processing time in a clinical setting as well as the cost and complexity of the optical system
Keywords:
biomedical optical imaging;cancer;fibre optic sensors;fluorescence spectroscopy;gynaecology;optical design techniques;statistical analysis;tumours;ultraviolet spectroscopy;visible spectroscopy;
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