Publications [#132188] of James M Provenzale

Papers Published

1. JM Provenzale, S Mukundan, M Dewhirst, The role of blood-brain barrier permeability in brain tumor imaging and therapeutics., AJR. American journal of roentgenology, vol. 185 no. 3 (September, 2005), pp. 763-7, ISSN 0361-803X [doi]
   (last updated on 2013/05/16)

   Abstract:
   OBJECTIVE: Our purpose is to describe methods of assessing leakiness of the blood-brain barrier and explain mechanisms for exploiting the blood-brain barrier for therapeutic purposes. CONCLUSION: Knowledge of the workings of the blood-brain barrier is important for an understanding of the ways in which blood-brain barrier permeability may be used as a surrogate marker for drug therapeutic response. Manipulation of the blood-brain barrier may provide a means for selectively targeting tumors for drug delivery.

   Keywords:
   Animals • Biological Transport • Blood-Brain Barrier • Brain Neoplasms • Contrast Media • Humans • Magnetic Resonance Imaging* • Neovascularization, Pathologic • Permeability • diagnosis • diagnosis* • physiology* • physiopathology • therapy • therapy*