Fitzpatrick Institute for Photonics Fitzpatrick Institute for Photonics
Pratt School of Engineering
Duke University

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Richard T. Di Giulio, Sally Kleberg Professor of Environmental Toxicology

Richard T. Di Giulio

Dr. Di Giulio serves as Director of Duke University's Integrated Toxicology Program and the Superfund Basic Research Center. Dr. Di Giulio's research is concerned with basic studies of mechanisms of contaminant metabolism, adaptation and toxicity, and with the development of mechanistically-based indices of exposure and toxicity that can be employed in biomonitoring. The long term goals of this research are to bridge the gap between mechanistic toxicological research and the development of useful tools for environmental assessment, and to elucidate linkages between human and ecosystem health. The bulk of Dr. Di Giulio's work employs a comparative approach with aquatic animals, particularly fishes, as models. Of particular concern are mechanisms of oxidative metabolism of aromatic hydrocarbons, mechanisms of free radical production and antioxidant defense, and mechanisms of chemical carcinogenesis, developmental perturbations and adaptations to contaminated environments by fishes.

Contact Info:
Office Location:  A346B LSRC
Office Phone:  (919) 613-8024
Email Address: send me a message


PhDVirginia Polytechnic Institute and State University
MSLouisiana State University
BAUniversity of Texas at Austin

environmental toxicology
environmental genomics
environmental health
estuarine ecosystems
marine biomedicine
water quality

Recent Publications   (More Publications)

  1. BW Clark, AJ Bone, RT Di Giulio, Resistance to teratogenesis by F1 and F2 embryos of PAH-adapted Fundulus heteroclitus is strongly inherited despite reduced recalcitrance of the AHR pathway., Environmental science and pollution research international (December, Accepted, 2013), ISSN 1614-7499  [abs]
  2. M Auffan, CW Matson, J Rose, M Arnold, O Proux, B Fayard, W Liu, P Chaurand, MR Wiesner, JY Bottero, RT Di Giulio, Salinity-dependent silver nanoparticle uptake and transformation by Atlantic killifish (Fundulus heteroclitus) embryos., Nanotoxicology (December, Accepted, 2013), ISSN 1743-5404  [abs]
  3. C Levard, EM Hotze, BP Colman, AL Dale, L Truong, XY Yang, AJ Bone, GE Brown Jr, RL Tanguay, RT Di Giulio, ES Bernhardt, JN Meyer, MR Wiesner, GV Lowry, Sulfidation of silver nanoparticles: natural antidote to their toxicity., Environmental science & technology, vol. 47 no. 23 (December, 2013), pp. 13440-8, ISSN 1520-5851  [abs]
  4. G Bozinovic, TL Sit, R Di Giulio, LF Wills, MF Oleksiak, Genomic and physiological responses to strong selective pressure during late organogenesis: few gene expression changes found despite striking morphological differences., BMC genomics, vol. 14 no. 1 (November, Accepted, 2013), pp. 779, ISSN 1471-2164  [abs]
  5. LV Garner, DR Brown, RT Di Giulio, Knockdown of AHR1A but not AHR1B exacerbates PAH and PCB-126 toxicity in zebrafish (Danio rerio) embryos., Aquatic toxicology (Amsterdam, Netherlands), vol. 142-143 (October, 2013), pp. 336-46, ISSN 1879-1514  [abs]

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