Bruce M. Klitzman, Assistant Research Professor of Surgery-Plastic Max & Oral Surgery and Biomedical Engineering
|Office Location:||0019 Res PK IV|
- PhD, University of Virginia, 1979
- Ph.D., University of Virginia, 1979
- BSE, Duke University, 1974
- Ph.D., University of Virginia, 1979
- Research Interests:
The primary basic science research interests of our laboratory are in the area of physiological mechanisms of maintaining substrate transport from blood to tissue. This broad topic covers studies on whole animals, such as rats and mice, as well as studies on whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular levels. The current projects include: 1) control of blood flow and flow distribution in the microcirculation; 2) the effects of synthetic and biologic implants on substrate transport to tissues; 3) the physiological adaptation of the microcirculation and mitochondria to chronic hypoxia, hyperoxia, or cold, and the subsequent alteration in oxygen transport; 4) mathematical modeling of tissue oxygen tension distribution and angiogenesis. 5) tissue engineering; combining isolated cells with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials; 6) decreasing the thrombogenicity of synthetic blood vessels and improving their overall performance and biocompatibility; 7) the investigation of tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage; 8) the abnormal development of tumor microcirculation and its effect on tumor oxygenation; 9) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential; 10) development of biocompatible materials for soft tissue reconstruction or augmentation; 11) molecular and cellular effects of ultraviolet light on skin which can lead to cancer, and therapies which may minimize damage; 12) wound healing in bone and soft tissues, with special emphasis on the detection and treatment of infection and its effects on healing. 13) improving the outflow facility of ophthalmologic devices implanted to reduce elevated intraocular pressures found in patients with glaucoma. Future studies will continue to focus on improving the biocompatibility of biosynthetic implants. Additional new emphasis may be placed on investigating the effects of radiation on wound healing and methods of minimizing the consequences of radiation exposure. Specific collaborations with faculty in Biomedical Engineering include improving the biocompatibility of biosensors, surface modification of implanted devices, and transplanting endothelial cells onto small diameter synthetic vascular grafts.
Tissue Repair, Tissue Engineering
Sensing and Sensor Systems
- BES 301B.16, RESEARCH IN BES
- TBA, 12:00 AM-12:00 AM
- BES 301B.16-S, RESEARCH IN BES
- TBA, 12:00 AM-12:00 AM
- Representative Publications
- HE Koschwanez, FY Yap, B Klitzman, WM Reichert, In vitro and in vivo characterization of porous poly-L-lactic acid coatings for subcutaneously implanted glucose sensors., Journal of biomedical materials research. Part A, vol. 87 no. 3 (December, 2008), pp. 792-807 [doi] [abs].
- HL Prichard, W Reichert, B Klitzman, IFATS collection: Adipose-derived stromal cells improve the foreign body response., Stem cells (Dayton, Ohio), vol. 26 no. 10 (October, 2008), pp. 2691-5 [doi] [abs].
- SJ Kovach, KE Koger, B Klitzman, G Germann, LS Levin, Advantages of minimally invasive, balloon-dissector-assisted tissue expander placement: a clinical and experimental study., Annals of plastic surgery, vol. 60 no. 1 (January, 2008), pp. 89-97 [doi] [abs].
- EM Hetrick, HL Prichard, B Klitzman, MH Schoenfisch, Reduced foreign body response at nitric oxide-releasing subcutaneous implants., Biomaterials, vol. 28 no. 31 (November, 2007), pp. 4571-80 [doi] [abs].
- A Baccarani, K Yasui, KC Olbrich, A El-Sabbagh, S Kovach, KE Follmar, D Erdmann, LS Levin, JS Stamler, B Klitzman, MR Zenn, Efficacy of ethyl nitrite in reversing surgical vasospasm., Journal of reconstructive microsurgery, vol. 23 no. 5 (July, 2007), pp. 257-62 [doi] [abs].
- LW Norton, HE Koschwanez, NA Wisniewski, B Klitzman, WM Reichert, Vascular endothelial growth factor and dexamethasone release from nonfouling sensor coatings affect the foreign body response., Journal of biomedical materials research. Part A, vol. 81 no. 4 (June, 2007), pp. 858-69 [doi] [abs].
- KE Follmar, HL Prichard, FC DeCroos, HT Wang, LS Levin, B Klitzman, KC Olbrich, D Erdmann, Combined bone allograft and adipose-derived stem cell autograft in a rabbit model., Annals of plastic surgery, vol. 58 no. 5 (May, 2007), pp. 561-5 [doi] [abs].
- HL Prichard, WM Reichert, B Klitzman, Adult adipose-derived stem cell attachment to biomaterials., Biomaterials, vol. 28 no. 6 (February, 2007), pp. 936-46 [doi] [abs].
- C Heitmann, FN Khan, D Erdmann, KC Olbrich, A Adam Sharkawy, B Klitzman, Vein graft anastomoses with magnets., Journal of plastic, reconstructive & aesthetic surgery : JPRAS, vol. 60 no. 12 (2007), pp. 1296-301 [doi] [abs].
- J Lanzen, RD Braun, B Klitzman, D Brizel, TW Secomb, MW Dewhirst, Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor., Cancer research, vol. 66 no. 4 (February, 2006), pp. 2219-23 [doi] [abs].
- BJ Nablo, HL Prichard, RD Butler, B Klitzman, MH Schoenfisch, Inhibition of implant-associated infections via nitric oxide release., Biomaterials, vol. 26 no. 34 (December, 2005), pp. 6984-90 [doi] [abs].
- J Ko, J Ross, H Awad, H Hurwitz, B Klitzman, The effects of ZD6474, an inhibitor of VEGF signaling, on cutaneous wound healing in mice., The Journal of surgical research, vol. 129 no. 2 (December, 2005), pp. 251-9 [doi] [abs].
- BS Sorg, CD Peltz, B Klitzman, MW Dewhirst, Method for improved accuracy in endogenous urea recovery marker calibrations for microdialysis in tumors., Journal of pharmacological and toxicological methods, vol. 52 no. 3 (July, 2005), pp. 341-9 [doi] [abs].
- BP Chan, W Liu, B Klitzman, WM Reichert, GA Truskey, In vivo performance of dual ligand augmented endothelialized expanded polytetrafluoroethylene vascular grafts., Journal of biomedical materials research. Part B, Applied biomaterials, vol. 72 no. 1 (January, 2005), pp. 52-63 [doi] [abs].
- Q Dai, J Huang, B Klitzman, C Dong, PJ Goldschmidt-Clermont, KL March, J Rokovich, B Johnstone, EJ Rebar, SK Spratt, CC Case, CD Kontos, BH Annex, Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia., Circulation, vol. 110 no. 16 (October, 2004), pp. 2467-75 [doi] [abs].
- D Erdmann, AM Pippen, KJ Moquin, R Sweis, LE Niklason, LS Levin, KC Olbrich, B Klitzman, Immunohistochemical identification of vascular endothelial growth factor in pig latissimus dorsi musculocutaneous flaps following ischemia-reperfusion injury., Annals of plastic surgery, vol. 53 no. 4 (October, 2004), pp. 398-403 [abs].
- D Erdmann, R Sweis, C Heitmann, K Yasui, KC Olbrich, LS Levin, AA Sharkawy, B Klitzman, Side-to-side sutureless vascular anastomosis with magnets., Journal of vascular surgery, vol. 40 no. 3 (September, 2004), pp. 505-11 [doi] [abs].
- MS Wong, D Erdmann, R Sweis, C Pöllmann, M Farrar, GS Georgiade, LS Levin, KC Olbrich, B Klitzman, Basic fibroblast growth factor expression following surgical delay of rat transverse rectus abdominis myocutaneous flaps., Plastic and reconstructive surgery, vol. 113 no. 7 (June, 2004), pp. 2030-6 [abs].
- D Erdmann, R Sweis, MS Wong, LE Niklason, TV du Laney, LS Levin, B Klitzman, KC Olbrich, Vascular endothelial growth factor expression in pig latissimus dorsi myocutaneous flaps after ischemia reperfusion injury., Plastic and reconstructive surgery, vol. 111 no. 2 (February, 2003), pp. 775-80 [doi] [abs].
- D Erdmann, R Sweis, MS Wong, CE Eyler, KC Olbrich, LS Levin, G Germann, B Klitzman, [Current perspectives of orthogonal polarization spectral imaging in plastic surgery]., Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen, vol. 73 no. 8 (August, 2002), pp. 827-32 [abs].
- Klitzman B., R.D. Braun, A.C. Lockhart, L. Heller, M.W. Dewhirst, and H.I. Hurwitz. Wound-induced angiogenesis: A clinical model. Prog Appl Microcirc 24:11-15, 2000 .
- RE Sachse, SA Fink, B Klitzman, Multimodality evaluation of pressure relief surfaces., Plastic and reconstructive surgery, vol. 102 no. 7 (December, 1998), pp. 2381-7 [abs].
- RE Sachse, SA Fink, B Klitzman, Comparison of supine and lateral positioning on various clinically used support surfaces., Annals of plastic surgery, vol. 41 no. 5 (November, 1998), pp. 513-8 [abs].
- B Klitzman, C Kalinowski, SL Glasofer, L Rugani, Pressure ulcers and pressure relief surfaces., Clinics in plastic surgery, vol. 25 no. 3 (July, 1998), pp. 443-50 [abs].
- AA Sharkawy, B Klitzman, GA Truskey, WM Reichert, Engineering the tissue which encapsulates subcutaneous implants. I. Diffusion properties., Journal of biomedical materials research, vol. 37 no. 3 (December, 1997), pp. 401-12 [abs].
- EF Ritter, YB Kim, HP Reischl, D Serafin, AM Rudner, B Klitzman, Heparin coating of vascular prostheses reduces thromboemboli., Surgery, vol. 122 no. 5 (November, 1997), pp. 888-92 [abs].
- EF Ritter, M Axelrod, KW Minn, E Eades, AM Rudner, D Serafin, B Klitzman, Modulation of ultraviolet light-induced epidermal damage: beneficial effects of tocopherol., Plastic and reconstructive surgery, vol. 100 no. 4 (September, 1997), pp. 973-80 [abs].
- PJ Viscardi, EA Page, HG Clark, D Serafin, B Klitzman, Iloprost in alginate decreases the thrombogenicity of expanded polytetrafluoroethylene., Journal of reconstructive microsurgery, vol. 13 no. 4 (May, 1997), pp. 303-6 [doi] [abs].
- Problems in General Surgery: Biomaterials. ed. B. Klitzman. Lippincott, 1994. .
- B Klitzman, Rheology and the regulation of oxygen delivery., Microsurgery, vol. 15 no. 6 (1994), pp. 369-73 .
- Current Ph.D. Students
- Heather L Prichard