David E Hinton, Professor of Nicholas School of the Environment and Civil and Environmental Engineering  


David E Hinton

Chronic toxicity in small, aquarium fish species. Using a mutant medaka (Oryzias latipes) that expresses no pigment, we are able to image internal organs in the intact living individual. Transgenic organisms are being developed to enhance our ability to discern disease processes within living fish of all life stages. Special projects include: 1 R01 RR18583-01 (NIH,NCRR) The compressed life cycle of the medaka, when coupled with its transparent features, makes this model particularly well suited to study post-embryonic development, aging, toxicity, mutagenesis and carcinogenesis. Particularly important is a model for evaluating manifestations of early life stage exposure where initial molecular derangement may be separated from adult dysfunction by long intervals. 01-HHE-4A (Water Environmental Research Foundation) "Use of Japanese medaka as an online screening platform for evaluation of potable waters"- Waste water intended for direct or indirect potable reuse has been highly treated to efficiently remove organic and inorganic contaminants. This biomonitoring platform will center on medaka as biosensors testing water for undesirable effects due to contaminant(s) or to purification chemicals or their interaction(s). We are also using this model to test the efficacy of new methods to break down chemicals in sewage treatment. Other studies to evaluate hepatobiliary toxicity during preclinical development of chemotherapeutic drugs are planned and funding sought. We anticipate this model can be employed as both a rapid screen for optimization of the lead molecule series selection in drug development (i.e., acute toxicity studies) but also for long-term studies that seek to determine adult consequences of early life stage toxicity.

Contact Info:
Office Location:  A333a LSRC
Office Phone:  (919) 613-8038
Email Address:   send me a message
Web Page:

Education:

PhD Anatomy, University of Mississippi, Medical Center,, 1968
MS Anatomy, University of Mississippi, Medical Center, 1967
BS Zoology, Mississippi College, 1965
Curriculum Vitae
Research Interests: Mechanistic and integrative understanding of the manner in which environmental contaminants exert their effects. Pathobiology and toxicopathology of persistent environmental contaminants in fishes: deciphering deleterious effect and establishing causal li

Specialties:

environmental toxicology
coastal zone management
environmental health
fisheries policy and management
water quality
wetland ecology
Awards, Honors, and Distinctions

David E. Hinton, January, 2011
Ehrendoktorate Vetsuisse- Fakultat, University of Bern, December, 2009
Teaching (Fall 2012):

  • ENVIRON 898.07, PROGRAM AREA SYMPOSIUM Synopsis
    LSRC A312, F 03:05 PM-04:20 PM
Recent Publications   (More Publications)

  1. CY Fan, SO Simmons, SH Law, K Jensen, J Cowden, D Hinton, S Padilla, R Ramabhadran, Generation and characterization of neurogenin1-GFP transgenic medaka with potential for rapid developmental neurotoxicity screening., Aquatic toxicology (Amsterdam, Netherlands), vol. 105 no. 1-2 (September, 2011), pp. 127-35  [abs].
  2. PD Noyes, DE Hinton, HM Stapleton, Accumulation and debromination of decabromodiphenyl ether (BDE-209) in juvenile fathead minnows (Pimephales promelas) induces thyroid disruption and liver alterations., Toxicological sciences : an official journal of the Society of Toxicology, vol. 122 no. 2 (August, 2011), pp. 265-74 [doi]  [abs].
  3. W Dong, DE Hinton, SW Kullman, TCDD Disrupts Hypural Skeletogenesis during Medaka Embryonic Development., Toxicological sciences : an official journal of the Society of Toxicology, vol. 125 no. 1 (Accepted, 2011), pp. 91-104  [abs].
  4. NK Cheung, DE Hinton, DW Au, A high-throughput histoarray for quantitative molecular profiling of multiple, uniformly oriented medaka (Oryzias latipes) embryos., Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, vol. 155 no. 1 (Accepted, 2011), pp. 18-25  [abs].
  5. KC Cheng, DE Hinton, CJ Mattingly, A Planchart, Aquatic models, genomics and chemical risk management., Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, vol. 155 no. 1 (Accepted, 2011), pp. 169-73  [abs].