Richard T Di Giulio, Professor of Nicholas School of the Environment and Civil and Environmental Engineering and Director, Superfund Basic Research Center; Director, Integrated Toxicology Program.  


Richard T Di Giulio

Dr. Di Giulio serves as Director of Duke University's Integrated Toxicology Program and the Superfund Basic Research Center. Dr. Di Giulio's research is concerned with basic studies of mechanisms of contaminant metabolism, adaptation and toxicity, and with the development of mechanistically-based indices of exposure and toxicity that can be employed in biomonitoring. The long term goals of this research are to bridge the gap between mechanistic toxicological research and the development of useful tools for environmental assessment, and to elucidate linkages between human and ecosystem health. The bulk of Dr. Di Giulio's work employs a comparative approach with aquatic animals, particularly fishes, as models. Of particular concern are mechanisms of oxidative metabolism of aromatic hydrocarbons, mechanisms of free radical production and antioxidant defense, and mechanisms of chemical carcinogenesis, developmental perturbations and adaptations to contaminated environments by fishes.

Contact Info:
Office Location:  A346b Lev Sci Res Ctr
Office Phone:  (919) 613-8024
Email Address:   send me a message
Web Page:

Education:

PhD, Virginia Polytechnic Institute and State University
MS, Louisiana State University
BA, University of Texas at Austin
Research Interests: Environmental toxicology, environmental health, and freshwater and estuarine pollution.

Specialties:

environmental toxicology
environmental genomics
environmental health
estuarine ecosystems
marine biomedicine
water quality
Awards, Honors, and Distinctions

US EPA Science and Tecnological Achievement Award, US EPA, July, 2010
Teaching (Fall 2012):

  • ENVIRON 501.01, ENVIRONMENTAL TOXICOLOGY Synopsis
    LSRC A155, MW 10:05 AM-11:20 AM
Recent Publications   (More Publications)

  1. TT Lindberg, ES Bernhardt, R Bier, AM Helton, RB Merola, A Vengosh, RT Di Giulio, Cumulative impacts of mountaintop mining on an Appalachian watershed., Proceedings of the National Academy of Sciences of the United States of America, vol. 108 no. 52 (December, 2011), pp. 20929-34 [doi]  [abs].
  2. MR Wiesner, GV Lowry, E Casman, PM Bertsch, CW Matson, RT Di Giulio, J Liu, MF Hochella Jr, Meditations on the ubiquity and mutability of nano-sized materials in the environment., ACS nano, vol. 5 no. 11 (November, 2011), pp. 8466-70 [doi]  [abs].
  3. D Jung, CW Matson, LB Collins, G Laban, HM Stapleton, JW Bickham, JA Swenberg, RT Di Giulio, Genotoxicity in Atlantic killifish (Fundulus heteroclitus) from a PAH-contaminated Superfund site on the Elizabeth River, Virginia., Ecotoxicology (London, England), vol. 20 no. 8 (November, 2011), pp. 1890-9 [doi]  [abs].
  4. BW Clark, RT Di Giulio, Fundulus heteroclitus adapted to PAHs are cross-resistant to multiple insecticides., Ecotoxicology (London, England) (October, 2011) [doi]  [abs].
  5. CR Fleming, RT Di Giulio, The role of CYP1A inhibition in the embryotoxic interactions between hypoxia and polycyclic aromatic hydrocarbons (PAHs) and PAH mixtures in zebrafish (Danio rerio)., Ecotoxicology (London, England), vol. 20 no. 6 (August, 2011), pp. 1300-14 [doi]  [abs].