- Hildebrandt, W. H. and Cocks, F. H., LOW TEMPERATURE CRYSTALLIZATION OF GLASSES IN THE H//2O EM DASH NaCl EM DASH DIMETHYL SULPHOXIDE TERNARY SYSTEM.,
Journal of Materials Science, vol. 9 no. 8
pp. 1325 - 1330 [BF00551851] .
(last updated on 2007/04/10)
Dimethyl sulphoxide (DMSO) is a widely used cryoprotective agent and in this investigation the H//2O-NaCl-DMSO system appears to develop a glossy phase even at relatively low cooling rates (25C min** minus **1) for those water-rich compositions where the ratio of DMSO to NaCl varies from 2 to one-half . This glassy phase is relatively unstable and the kinetics of the glass-to-crystalline phase transition have been investigated and shown to be first order. Activation energies (Q) and the times required for the completion of this first order transformation have been evaluated by differential thermal analysis. Such information may be useful in interpreting the effects of long term storage on rapidly frozen biological materials perfused with DMSO.