Papers Published

1. Hyun, Jinho and Ma, Hongwei and Zhang, Zhanping and Beebe Jr., Thomas P. and Chilkoti, Ashutosh, Universal route to cell micropatterning using an amphiphilic comb polymer, Advanced Materials, vol. 15 no. 7-8 (2003), pp. 576 - 579 [adma.200304496] .
   (last updated on 2007/04/12)

   Abstract:
   Micropatterning of localized chemical or biochemical domains has the potential to become a powerful tool to control the behavior of anchorage-dependent cells. However, several problems, such as the limited types of substrates that can be successfully patterned with cells and the lack of reliable, long-term retention of cellular patterns under physiological conditions need to be solved for cellular patterning to become widely applicable for cell-based biosensors, biomaterials, and high-throughput drug screening assay. This paper reports on a simple and generic method to micropattern surfaces with an amphiphilic comb polymer presenting short oligoethylene glycol side chains that enables long-term, spatially resolved attachment and growth of mammalian cells in a biologically relevant milieu on a variety of substrates.

   Keywords:
   Cells;Growth kinetics;Oligomers;Biomaterials;Surfaces;Proteins;Cell culture;Adsorption;Secondary ion mass spectrometry;Polystyrenes;Positive ions;