- Dreher, M. and Raucher, D. and Balu, N. and Colvin, M. and Hudeman, S. and Chilkoti, A., Elastin-like polypeptide-doxorubicin conjugates for cancer therapy,
Conference Proceedings. Second Joint EMBS-BMES Conference 2002. 24th Annual International Conference of the Engineering in Medicine and Biology Society. Annual Fall Meeting of the Biomedical Engineering Society (Cat. No.02CH37392), vol. vol.1
pp. 524 - 5 [IEMBS.2002.1136930] .
(last updated on 2007/04/12)
Thermally responsive elastin-like polypeptides (ELP) were synthesized by recombinant DNA techniques and conjugated to doxorubicin through an acid labile bond. The thermal properties, release of doxorubicin, uptake of ELP, cytotoxicity and cellular localization of ELP-doxorubicin conjugates were investigated in this study
biochemistry;biothermics;cancer;cellular transport;DNA;patient treatment;polymers;proteins;tumours;