- Meyer, Dan E. and Chilkoti, Ashutosh, Quantification of the effects of chain length and concentration on the thermal behavior of elastin-like polypeptides,
Biomacromolecules, vol. 5 no. 3
pp. 846 - 851 [bm034215n] .
(last updated on 2007/04/12)
At a specific temperature, elastin-like polypeptides (ELPs) undergo a sharp solubility transition that can be exploited in a variety of applications in biotechnology and medicine. The temperature of the transition varies with ELP sequence, molecular weight, and concentration. We present a single equation of three parameters that quantitatively predicts the transition temperature as a function of ELP length and concentration for an ELP of a fixed composition. This model should be useful both for the design of new ELP sequences that exhibit a desired transition temperature and for the selection of variables to trigger the phase transition of an ELP for a given application. © 2004 American Chemical Society.
Proteins;Biotechnology;Medicine;Molecular weight;Superconducting transition temperature;Phase transitions;