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Papers Published

  1. Meyer, D.E. and Kong, G. and Dewhirst, M. and Chilkoti, A., A genetically-engineered polypeptide carrier for thermal targeting of therapeutics, Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. No.99CH37015), vol. vol.2 (1999), pp. 1289 vol.2 - [IEMBS.1999.804458] .
    (last updated on 2007/04/12)

    Abstract:
    Reports the synthesis of a environmentally-responsive polypeptide carrier for thermally-targeted delivery of radionuclide therapeutics. The authors hypothesized that systemically-injected radionuclide-polypeptide conjugates are likely to be cleared from circulation under physiological conditions, while externally-induced local hyperthermia at tumor sites will result in radionuclide accumulation because of carrier aggregation. The authors report preliminary in vivo results which support this hypothesis

    Keywords:
    genetics;hyperthermia;radiation therapy;radioisotopes;tumours;