- Kiser, Patrick F. and Needham, David and Wilson, Glynn, Mimicking the smart polymer matrix of the secretory granule: a new concept in controlled release drug delivery,
Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering, vol. 76
pp. 226 - .
(last updated on 2007/04/06)
Regulated secretion of biological molecules is controlled by specialized secretory cells. The design of a multi-component drug delivery system which can closely mimic the properties of the secretary granule will have utility for triggered release of drugs. This study demonstrates the potential of a synthetic, smart polymer system which mimics the smart polymer matrix of secretory cells in phase transition behavior.
Hydrogels;Synthesis (chemical);Phase transitions;Cell membranes;Molecules;Proteins;Drug products;Polymerization;Dispersions;Ions;Diffusion;Hydrolysis;