publications by David Needham.

Papers Published

1. Needham, David and Noppl-Simson, Doris, Barrier properties of surface-grafted PEG for macromolecule-surface interactions, American Chemical Society, Polymer Priprints, Division of Polymer Chemistry, vol. 38 no. 1 (1997), pp. 549 - 550 .
   (last updated on 2007/04/06)

   Abstract:
   The extent in which a grafted-polyethylene glycols (PEG) can restrain the adsorption and binding of avidin-biotin surface interactions was investigated using a micropipet technique. A polymer-grafted surface have a greater or lesser permeability to the adsorption of molecular and macromolecular species of a given size and surface interaction depending on the grafted-polymer concentration regime (mushroom or brush). The overall rate of avidin-biotin binding depend on the PEG surface density and the grafted PEG decreased the rate of avidin-biotin association reducing the diffusion constant for avidin transport to the vesicle surface.

   Keywords:
   Graft copolymers;Macromolecules;Surface phenomena;