publications by David Needham.

Papers Published

1. Needham, David, Lipid Membranes: Biological Inspiration for Micro and Nano Encapsulation Technologies, Especially Drug Delivery, Materials Research Society Symposium - Proceedings, vol. 774 (2003), pp. 173 - 202 .
   (last updated on 2007/04/06)

   Abstract:
   The development and performance of liposomes for releasing drug locally and in large amounts to affect tumor growth were discussed. The significance of inspired biological approach to micro and nano encapsulation technologies was also discussed. The mechanism of drug release was non-natural for the inspiration provided by nature's encapsulation technology. Various parameters for drug encapsulation such as drug retention, circulation half life, and thermally-triggered drug release were obtained from artificial lipid vesicles. The temperature-triggered liposome was developed for treating solid tumors.

   Keywords:
   Lipids;Cell membranes;Tumors;Oncology;Encapsulation;Blood;Chemotherapy;Thermomechanical treatment;Toxicity;Thermal effects;Macromolecules;DNA;RNA;Medical applications;