- Zhelev, Doncho V. and Needham, David, Pore formation and pore dynamics in bilayer membranes,
American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD, vol. 337
pp. 47 - 49 .
(last updated on 2007/04/06)
Pore formation in cell membrane is widely used to deliver hydrophilic substances to the cell interior. Among the methods used for pore formation are electroporation and exposure of the membrane to mild surfactants. Both in electroporation and when surfactants are used, pores form mainly in lipid membrane domains. Thus, the use of model membranes allows to access important characteristics of pore formation and dynamics, such as their dependence on membrane tension. The role of these characteristics in pore formation is determined by using single lipid vesicles, which are manipulated by glass micropipets.
Porous materials;Molecules;Calculations;Cholesterol;Lipids;DNA;Surface active agents;Gibbs free energy;