- Hochmuth, R.M. and Needham, D. and Ting-Beall, H.P., Deformation and flow of neutrophils and monocytes,
American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, vol. 20
pp. 417 - 419 .
(last updated on 2007/04/06)
The deformation and flow of neutrophils and monocytes in the smallest vessels is studied experimentally. The preparation of cells, micropipet manipulation, measurement of cortical tension, measurement of viscosity and of the rate of recovery is described. It is concluded that neutrophils and monocytes behave more like a liquid than a solid. However. it is a simplification to say that these cells behave like a Newtonian liquid drop with a constant cortical tension. The cell's complex cytoplasmic fluid has a distionctly non-Newtonian character. It responds elastically when deformed rapidly, but its elastic memory fades quickly - in less than 5 seconds. The behavior of the neutrophil as a Maxwell liquid may account for its shear-thinning behavior. The cortical tension also may change as the cell is deformed.