- Yu, Q. and Shivapooja, P. and Johnson, L. M. and Tizazu, G. and Leggett, G. J. and Lopez, G. P., Nanopatterned polymer brushes as switchable bioactive interfaces,
Nanoscale, vol. 5 no. 9
pp. 3632--3637 [doi] .
(last updated on 2013/06/21)
We report convenient methods for synthesis of nanopatterned, thermally responsive brushes of poly(N-isopropyl acrylamide) over large areas (e.g., 1 cm(2)) to form model, dynamic, biofunctional surfaces. The new nanopatterned brush structure can be used to control (i) the rate of both nonspecific and biospecific adsorption processes at the polymer-graft-free regions of the substrate, and (ii) the rate of cell detachment. These capabilities have potential implications in a number of areas of biotechnology including biosensing, separations and cell culture.