Papers Published

  1. Erickson, Geoffrey R. and Guilak, Farshid, Osmotic stress initiates intracellular calcium waves in chondrocytes through extracellular influx and the inositol phosphate pathway, American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, vol. 44 (1999), pp. 43 - 44 .
    (last updated on 2007/04/15)

    Abstract:
    A study was carried out to examine the hypothesis that osmotic stress initiates a transient increase in the concentration of intracellular calcium ion ([Ca2+]i), and to determine the mechanisms of Ca2+ mobilization in isolated chondrocytes exposed to hypo- and hyper-osmotic stress. Osmotic stress was determined by performing tests within 12 hrs of isolation. The results indicate that both hypo- and hyper-osmotic result in significant increases and oscillations in [Ca2+]i in chondrocytes.

    Keywords:
    Cells;Calcium;Organic compounds;Cartilage;Physiology;Cell culture;Cell immobilization;Osmosis;Kinematics;