- Masters, K. S. B. and Lipke, E. A. and Rice, E. E. H. and Liel, M. S. and Myler, H. A. and Zygourakis, C. and Tulis, D. A. and West, J. L., Nitric oxide-generating hydrogels inhibit neointima formation,
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, vol. 16 no. 5
pp. 659--672 .
(last updated on 2012/02/23)
This study evaluated the effects of localized delivery of nitric oxide (NO) from hydrogels covalently modified with S-nitrosocysteine (Cys-NO) on neoinitma formation, a key component of restenosis, in a rat balloon-injury model. Soluble Cys-NO was used in preliminary studies to identify dosage ranges that were able to simultaneously inhibit smooth muscle cell proliferation, enhance endothelial cell proliferation, and reduce platelet adhesion. Photo-cross-linked PEG-based hydrogels were formed with covalently immobilized Cys-NO. These materials release NO for approximately 24 h and can be applied to tissues and photo-cross-linked in situ to form local drug-delivery systems. Localized delivery of NO from hydrogels containing Cys-NO inhibited neointima formation in a rat balloon-injury model by approximately 75\% at 14 days.