Papers Published
- Sayes, C. M. and Fortner, J. D. and Guo, W. and Lyon, D. and Boyd, A. M. and Ausman, K. D. and Tao, Y. J. and Sitharaman, B. and Wilson, L. J. and Hughes, J. B. and West, J. L. and Colvin, V. L., The differential cytotoxicity of water-soluble fullerenes,
NANO LETTERS, vol. 4 no. 10
(October, 2004),
pp. 1881--1887 [doi] .
(last updated on 2012/02/23)Abstract:
We show that the cytotoxicity of water-soluble fullerene species is a sensitive function of surface derivatization; in two different human cell lines, the lethal dose of fullerene changed over 7 orders of magnitude with relatively minor alterations in fullerene structure. In particular, an aggregated form Of C-60, the least derivatized of the four materials, was substantially more toxic than highly soluble derivatives such as C-3, Na-2-3(+)[C60O7-9(OH)(12-15)]((2-3)-), and C-60(OH)(24). Oxidative damage to the cell membranes was observed in all cases where fullerene exposure led to cell death. We show that under ambient conditions in water fullerenes can generate superoxide anions and postulate that these oxygen radicals are responsible for membrane damage and subsequent cell death. This work demonstrates both a strategy for enhancing the toxicity of fullerenes for certain applications such as cancer therapeutics or bactericides, as well as a remediation for the possible unwarranted biological effects of pristine fullerenes.