- Li, J. and Yang, C. and Li, H. Z. and Wang, X. and Goh, S. H. and Ding, J. L. and Wang, D. Y. and Leong, K. W., Cationic supramolecules composed of multiple oligoethylenimine-grafted beta-cyclodextrins threaded on a polymer chain for efficient gene delivery,
Advanced Materials, vol. 18 no. 22
pp. 2969-2974 .
(last updated on 2010/06/11)
Cationic supramolecules composed of mumple oligoethylenimine-grafted beta-cyclodextrins that are threaded and blocked on a triblock copolymer chain (see figure) are synthesized as gene-delivery vectors. The supramolecules contain many cationic cyclic units threaded on a polymer chain to form an integrated entity, functioning as a macromolecular gene vector with good DNA binding ability, low cytotoxicity, and high gene-transfection efficiency.
alpha-cyclodextrin polyamidoamine dendrimer conjugated polyrotaxanes inclusion complexation drug-delivery side-chain in-vivo therapy polypseudorotaxanes polyethylenimine