- Shi, F.Y. and Wang, L.F. and Leong, K.W., Synthesis and characterization of hydrolytically labile polyurethanes,
Polymer Preprints, Division of Polymer Chemistry, American Chemical Society, vol. 31 no. 2
pp. 177 - .
(last updated on 2007/04/13)
Polyurethane has been extensively studied and widely used as a biomedical material since the early 1960s. We have been designing biodegradable polyurethanes that contain a phosphorus ester linkage in the backbone to induce biodegradability and to link bioactive agents directly to the phosphorus atom. In this communication, we extend this study to polyurethanes which contain phospholipids in the side chain. Furthermore, with the objective of obtaining a polymer that would break down into non-toxic products, a lysine-based diisocyanate and a biodegradable chain extender are used for the polyurethane synthesis.
Polymers--Synthesis;Lipids--Chemical Reactions;Chemical Reactions--Hydrolysis;Drug Products--Controlled Delivery;