- Kadiyala, S. and Lo, H. and Ponticiello, M.S. and Reddi, A.H. and Leong, K.W., Bone induction achieved by controlled release of BMP from PLA/hydroxyapatite foams,
Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium, vol. 1
pp. 289 - .
(last updated on 2007/04/13)
In order to attain bone repair using bone morphogenic proteins (BMP), there is a need for a carrier which can effectively deliver the BMP to the repair site in a controlled fashion and at the same time provide a scaffold for the regenerating tissue to grow upon. The feasibility of using BMP loaded polylactic acid (PLA)/hydroxyapatite (HA) foam fabricated by a novel phase separation technique to induce osteogenesis in an ectopic site in a rat model is demonstrated. Results show that controlled release of BMP from highly porous foams fabricated by the phase separation technique is achieved. Furthermore implantation of these BMP loaded foams in vivo resulted in the ectopic induction of bone and cartilage.
Morphology;Organic acids;Phase separation;Cartilage;Scanning electron microscopy;Porosimeters;Implants (surgical);Proteins;Adsorption;Physiological models;Living systems studies;