- Wang, Jun and Sun, Daniel N. and Shin-ya, Yoshitsune and Leong, Kam W., Stimuli-responsive hydrogel based on poly(propylene phosphate),
Macromolecules, vol. 37 no. 2
pp. 670 - 672 [ma035453d] .
(last updated on 2007/04/13)
Poly(propylene phosphate) solutions were studied and found to display a sol-gel transition temperature that can be controlled by adjusting the concentrations of polymer and Ca2+ so that the therapeutic delivery cargo is liquid at room temperature but solidifies at the in vivo temperature of 37°C. The gels showed rapid gelation kinetics but instability at high shear strains. Ion exchange between buffer and gel induced a dissociation of the network with time, leading to a zero-order controlled release of plasmid DNA or lysozyme.
Hydrogels;Phase transitions;Synthesis (chemical);Biodegradation;Biocompatibility;Rheology;Shear stress;Temperature;Elastic moduli;Gel permeation chromatography;Nuclear magnetic resonance spectroscopy;