- Tran-Son-Tay, R. and Ting-Beall, H.P. and Zhelev, D.V. and Hochmuth, R.M., Study of the recovery of lymphocytes,
American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, vol. 26
pp. 341 - 342 .
(last updated on 2007/04/10)
Preliminary pipette experiments with lymphocytes indicate that they behave differently from the neutrophils when they are deformed. The mechanical description of the neutrophil has been a focus of research in recent years. It is now recognized that the neutrophil behaves as a fluid. However, it is still not clear if the best model for this type of cell is a viscoelastic fluid model based on separate layers or one based on two intermixed fluids. To a first order of approximation, the neutrophil's nucleus is not a major contributor to the mechanical behavior of the cell for the types of deformation studied. On the other hand, under identical experimental conditions, the large nucleus of the lymphocyte cannot be neglected and, indeed plays an important role in the cell's mechanical response. Recovery experiments in which a human lymphocyte is deformed into an elongated `sausage' shape by aspirating it into a small glass pipette and then expelled from the pipette are presented.
Biomechanics;Mathematical models;Viscosity;Mechanical properties;