- Hochmuth, R.M. and Mohandas, N. and Blackshear, P.L., Jr., Measurement of the elastic modulus for red cell membrane using a fluid mechanical technique,
Biophys. J. (USA), vol. 13 no. 8
pp. 747 - 62 .
(last updated on 2007/04/10)
Red cells which adhere to a surface in a parallel plate flow channel are stretched when acted on by a fluid shear stress. Three types of stretching are studied: whole cell stretching, the stretching of a red cell evagination, and tether (long, thin membrane process) stretching. In addition, the stretching of a large scale model cell attached to a surface is studied in a Couette flow channel. The results indicate that the uniaxial stretching of red cell membrane can be described by a linear stress-strain relationship. Simple theories developed from free body diagrams permit the calculation of a value for the modulus of elasticity of cell membrane in each of the three experiments
cellular biophysics;elastic constant measurement;membranes;