- Guilak, Farshid and Ting-Beall, H. Ping and Jones, Wendy R. and Lee, Greta M. and Hochmuth, Robert M., Mechanical properties of chondrocytes and chondrons,
American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, vol. 33
pp. 253 - 254 .
(last updated on 2007/04/10)
In this study, micropipette aspiration techniques were used to characterize the mechanical behavior and properties of chondrocytes and of the tissue comprising chondrons. Mechanical property measurements were made on a human chondrosarcoma cell line (KC2H3) and on primary human chondrocytes and chondrons isolated from osteoarthritic human articular cartilage. The morphology of the samples were characterized using optical and scanning electron microscopy. Results suggest that chondrocytes, chondrosarcoma cells, and the chondrocyte pericellular matrix behave as viscoelastic solids. This in turn indicate that the micropipette aspiration technique can provide a sensitive means of determining changes in cellular mechanics and local tissue properties at a microscopic scale.
Cells;Cartilage;Biomedical engineering;Computational geometry;Boundary conditions;Approximation theory;Elastic moduli;Stiffness;Numerical methods;