- Setton, L.A. and Baer, A.E. and Wang, J.Y. and Kraus, V.B., Biosynthesis of intervertebral disc matrix in vitro,
Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. No.99CH37015), vol. vol.2
pp. 1325 vol.2 - [IEMBS.1999.804494] .
(last updated on 2007/04/10)
Cells of the intervertebral disc are shown to express genes for aggrecan and collagen in an in vitro alginate culture system. Despite evidence for significant biosynthesis, the cells appear unable to assemble a mechanically functional matrix in this in vitro system
bone;cellular biophysics;genetics;molecular biophysics;proteins;