- Upton, M.L. and Chen, J. and Guilak, F. and Setton, L.A., Static compression inhibits matrix protein gene expression and increases collagenase gene expression in the meniscus,
Conference Proceedings. Second Joint EMBS-BMES Conference 2002. 24th Annual International Conference of the Engineering in Medicine and Biology Society. Annual Fall Meeting of the Biomedical Engineering Society (Cat. No.02CH37392), vol. vol.1
pp. 438 - 9 [IEMBS.2002.1136884] .
(last updated on 2007/04/10)
The biological response of the meniscus to static compression was quantified as changes in gene expression levels for relevant extracellular matrix proteins. Decreased mRNA levels for decorin and type I collagen were observed, as well as increased mRNA levels for the matrix metalloproteinase MMP-1. These findings demonstrate that the response of the meniscus to mechanical stimuli may be regulated in part at the transcriptional level