Papers Published

  1. Upton, M.L. and Chen, J. and Guilak, F. and Setton, L.A., Static compression inhibits matrix protein gene expression and increases collagenase gene expression in the meniscus, Conference Proceedings. Second Joint EMBS-BMES Conference 2002. 24th Annual International Conference of the Engineering in Medicine and Biology Society. Annual Fall Meeting of the Biomedical Engineering Society (Cat. No.02CH37392), vol. vol.1 (2002), pp. 438 - 9 [IEMBS.2002.1136884] .
    (last updated on 2007/04/10)

    The biological response of the meniscus to static compression was quantified as changes in gene expression levels for relevant extracellular matrix proteins. Decreased mRNA levels for decorin and type I collagen were observed, as well as increased mRNA levels for the matrix metalloproteinase MMP-1. These findings demonstrate that the response of the meniscus to mechanical stimuli may be regulated in part at the transcriptional level

    biological tissues;biomechanics;genetics;orthopaedics;proteins;