Papers Published

  1. Setton, Lori A. and Perry, Charles H. and LeRoux, Michelle A. and Wang, Jean Y. and Howell, David S. and Cheung, Herman S., Altered mechanics of tibial cartilage following joint immobilization in a canine model, American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, vol. 42 (1999), pp. 71 - 72 .
    (last updated on 2007/04/10)

    To study the effect of immobilization, the compressive and shear properties of articular cartilage were quantified at sites corresponding to those of elevated MMP staining on the tibial plateau of mongrel dogs. Cartilage samples were tested in compression and torsion on a displacement-controlled rheometer. The samples were weighed after testing and again after lyophilization to determine water content as the percentage of tissue wet weight. The results support the hypothesis that knee joint immobilization will produce deleterious changes in cartilage function at the tibial plateau.

    Cartilage;Joints (anatomy);Mathematical models;Biosynthesis;Enzymes;Collagen;