Papers Published

  1. Coles, Jeffrey M. and Chang, Debby P. and Zauscher, Stefan, Molecular mechanisms of aqueous boundary lubrication by mucinous glycoproteins, CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, vol. 15 no. 6 (December, 2010), pp. 406-416 [doi] .
    (last updated on 2011/08/19)

    Mucins have long been recognized as instrumental to biolubrication but the molecular details of their lubrication mechanisms have only been explored relatively recently The glycoprotein PRG4 also known as lubricin shares many features with mucins and appears to lubricate through similar mechanisms A number of studies have contributed to a more in-depth understanding of mum adsorption and layer formation on surfaces and the mechanisms by which these layers lubricate Although mucinous glycoproteins differ in their aggregation properties their adsorption behaviors on surfaces and in their ability to reduce friction they share important similarities favorable for lubrication They are highly hydrated they adsorb strongly to a broad range of surfaces and the layers they form are both sterically and electrostatically repulsive all attributes thought to contribute to boundary lubrication They also hydrophilize hydrophobic surfaces promoting the formation of aqueous fluid films that can lower friction at already relatively low sliding speeds In this paper we briefly review current knowledge of mum adsorption and lubrication with a focus on recent advances (C) 2010 Elsevier Ltd All rights reserved