Publications of Moria J. Smoski
%% Journal Articles
@article{fds336957,
Author = {Lavretsky, H and Wetherell, J and Smoski, MJ and Varteresian,
T},
Title = {Cultivation of Well-Being Through Mind-Body
Interventions},
Journal = {The American Journal of Geriatric Psychiatry},
Volume = {26},
Number = {3},
Pages = {S49-S50},
Publisher = {Elsevier BV},
Year = {2018},
Month = {March},
Doi = {10.1016/j.jagp.2018.01.079},
Key = {fds336957}
}
@article{fds336959,
Author = {Dichter, GS and Crowther, A and Minkel, J and Keng, S-L and Ji, JL and Eisenlohr-Moul, TA and Walsh, E and Smoski, MJ},
Title = {Neural Mechanisms of Emotion Regulation in Major Depression
and Implications for Psychotherapy Effectiveness},
Journal = {BIOLOGICAL PSYCHIATRY},
Volume = {79},
Number = {9},
Pages = {295S-295S},
Publisher = {ELSEVIER SCIENCE INC},
Year = {2016},
Month = {May},
Key = {fds336959}
}
@article{fds329148,
Author = {Rej, S and Smoski, MJ and Lavretsky, H and Newhouse,
P},
Title = {CAM for the Goose and the Gander: Demonstrations of
Mind-Body Practices for Patients and Practitioners},
Journal = {The American Journal of Geriatric Psychiatry},
Volume = {24},
Number = {3},
Pages = {S26-S27},
Publisher = {Elsevier BV},
Year = {2016},
Month = {March},
Doi = {10.1016/j.jagp.2016.01.038},
Key = {fds329148}
}
@article{fds276257,
Author = {Carl, H and Dichter, GS and Crowther, A and Minkel, J and Moore, T and Gibbs, D and Petty, C and Bizzell, J and Schiller, C and Sideris, J and Walsh, E and Smoski, MJ},
Title = {Endurance of Neural Response to Rewards Predicts
Post-Treatment Depression Severity},
Journal = {BIOLOGICAL PSYCHIATRY},
Volume = {77},
Number = {9},
Pages = {2 pages},
Publisher = {ELSEVIER SCIENCE INC},
Year = {2015},
Month = {May},
ISSN = {0006-3223},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352207501299&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds276257}
}
@article{fds276258,
Author = {Smoski, MJ and Suarez, EC and Brantley, J and Wolever, RQ and Greeson,
JM},
Title = {Effects of Mindfulness-Based Stress Reduction Across the
Adult Lifespan},
Journal = {The American Journal of Geriatric Psychiatry},
Volume = {23},
Number = {3},
Pages = {S168-S168},
Publisher = {Elsevier BV},
Year = {2015},
Month = {March},
ISSN = {1064-7481},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000350829500167&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Doi = {10.1016/j.jagp.2014.12.175},
Key = {fds276258}
}
@article{fds276263,
Author = {Smoski, MJ and Taylor, WD and Arean, P and Steffens,
DC},
Title = {Emotion Regulation in Late-Life Depression: Neural Models to
Treatment Strategies},
Journal = {The American Journal of Geriatric Psychiatry},
Volume = {22},
Number = {3},
Pages = {S15-S16},
Publisher = {Elsevier BV},
Year = {2014},
Month = {March},
ISSN = {1064-7481},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000336081800016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Doi = {10.1016/j.jagp.2013.12.022},
Key = {fds276263}
}
@article{fds276264,
Author = {Smoski, MJ and Steffens, D and LaBar, K},
Title = {Executive Function as a Moderator of Emotion Regulation in
Late-Life Depression},
Journal = {The American Journal of Geriatric Psychiatry},
Volume = {21},
Number = {3},
Pages = {S129-S130},
Publisher = {Elsevier BV},
Year = {2013},
Month = {March},
ISSN = {1064-7481},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330358400142&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Doi = {10.1016/j.jagp.2012.12.172},
Key = {fds276264}
}
@article{fds325130,
Author = {Smoski, MJ},
Title = {Reward Optimization and Behavioral Activation Treatment for
Late-Life Depression},
Journal = {AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY},
Volume = {20},
Number = {3},
Pages = {S156-S157},
Publisher = {ELSEVIER SCIENCE INC},
Year = {2012},
Month = {March},
Key = {fds325130}
}
@article{fds276275,
Author = {Payne, ME and Hayward, RD and Smoski, MJ and Krishnan, RR and Steffens,
DC and Taylor, WD},
Title = {Stress Vulnerability Moderates the Association between White
Matter Lesions and Late-Life Depression},
Journal = {BIOLOGICAL PSYCHIATRY},
Volume = {69},
Number = {9},
Pages = {170S-170S},
Publisher = {ELSEVIER SCIENCE INC},
Year = {2011},
Month = {May},
ISSN = {0006-3223},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000290641800543&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds276275}
}
@article{fds276273,
Author = {Smoski, MJ and Steffens, D and LaBar, K},
Title = {Functional Neuroimaging of Emotion Regulation in Late-Life
Depression},
Journal = {AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY},
Volume = {19},
Number = {3},
Pages = {S99-S100},
Publisher = {LIPPINCOTT WILLIAMS & WILKINS},
Year = {2011},
Month = {March},
ISSN = {1064-7481},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000289791000111&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds276273}
}
@article{fds276274,
Author = {Smoski, MJ and Steffens, D and LaBar, K},
Title = {Effectiveness of Reappraisal and Distraction as Emotion
Regulation Strategies in Late-Life MDD},
Journal = {AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY},
Volume = {19},
Number = {3},
Pages = {S66-S67},
Publisher = {LIPPINCOTT WILLIAMS & WILKINS},
Year = {2011},
Month = {March},
ISSN = {1064-7481},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000289791000064&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds276274}
}
%% Papers Published
@article{fds372227,
Author = {Darrow, SM and Pizzagalli, DA and Smoski, M and Mathew, SJ and Nurnberger, J and Lisanby, SH and Iosifescu, D and Murrough, JW and Yang, H and Weiner, RD and Sanacora, G and Keefe, RSE and Song, A and Goodman, W and Whitton, AE and Potter, WZ and Krystal,
AD},
Title = {Using latent profile analyses to classify subjects with
anhedonia based on reward-related measures obtained in the
FAST-MAS study.},
Journal = {J Affect Disord},
Volume = {339},
Pages = {584-592},
Year = {2023},
Month = {October},
Abstract = {BACKGROUND: Growing evidence indicates that anhedonia is a
multifaceted construct. This study examined the possibility
of identifying subgroups of people with anhedonia using
multiple reward-related measures to provide greater
understanding the Research Domain Criteria's Positive
Valence Systems Domain and pathways for developing
treatments. METHODS: Latent profile analysis of baseline
data from a study that examined the effects of a novel kappa
opioid receptor (KOR) antagonist drug on measures and
biomarkers associated with anhedonia was used to identify
subgroups. Measures included ventral striatal activation
during the Monetary Incentive Delay task, response bias in
the Probabilistic Reward Task, reward valuation scores from
the Effort-Expenditure for Rewards Task, and scores from
reward-related self-report measures. RESULTS: Two subgroups
were identified, which differed on self-report measures of
reward. Participants in the subgroup reporting more
anhedonia also reported more depression and had greater
illness severity and functional impairments. Graphs of
change with treatment showed a trend for the less severe
subgroup to demonstrate higher response to KOR antagonist
treatment on the neuroimaging measure, probabilistic reward
task, and ratings of functioning; the subgroup with greater
severity showed a trend for higher treatment response on
reward-related self-report measures. LIMITATIONS: The main
limitations include the small sample size and exploratory
nature of analyses. CONCLUSIONS: Evidence of possible
dissociation between self-reported measures of anhedonia and
other measures with respect to treatment response emerged.
These results highlight the importance for future research
to consider severity of self-reported reward-related
deficits and how the relationship across measurement methods
may vary with severity.},
Doi = {10.1016/j.jad.2023.07.081},
Key = {fds372227}
}
@article{fds371655,
Author = {Schuette, SA and Andrade, FC and Woodward, JT and Smoski,
MJ},
Title = {Identifying modifiable factors associated with psychological
health in women experiencing infertility.},
Journal = {J Health Psychol},
Volume = {28},
Number = {12},
Pages = {1143-1156},
Year = {2023},
Month = {October},
Abstract = {This study assessed the relationship between modifiable
psychological variables and depression, anxiety, and
posttraumatic growth in women experiencing infertility. U.S.
women (N = 457) who identified as experiencing infertility
completed standardized self-report measures of mindfulness,
self-compassion, positive affect, intolerance of
uncertainty, relationship satisfaction, experiential
avoidance, depression, anxiety, and posttraumatic growth.
Clinical and demographic characteristics (age, duration
trying to conceive, miscarriage, and childlessness) did not
predict depression or anxiety. Lower positive affect and
higher experiential avoidance were associated with
depression and anxiety. Lower self-compassion was associated
with depression; higher intolerance of uncertainty was
associated with anxiety. There were indirect effects of
mindfulness on anxiety and depression via these variables.
Future research should explore whether intervening on these
factors reduces depressive and anxiety symptoms. Promoting
mindfulness may have beneficial effects on symptoms via its
downstream effects on multiple coping variables.
Counterintuitively, posttraumatic growth was associated with
higher intolerance of uncertainty and experiential
avoidance.},
Doi = {10.1177/13591053231185549},
Key = {fds371655}
}
@article{fds371266,
Author = {Phillips, RD and Walsh, EC and Zürcher, NR and Lalush, DS and Kinard,
JL and Tseng, C-E and Cernasov, PM and Kan, D and Cummings, K and Kelley,
L and Campbell, D and Dillon, DG and Pizzagalli, DA and Izquierdo-Garcia, D and Hooker, JM and Smoski, MJ and Dichter,
GS},
Title = {Striatal dopamine in anhedonia: A simultaneous
[11C]raclopride positron emission tomography and functional
magnetic resonance imaging investigation.},
Journal = {Psychiatry Res Neuroimaging},
Volume = {333},
Pages = {111660},
Year = {2023},
Month = {August},
Abstract = {BACKGROUND: Anhedonia is hypothesized to be associated with
blunted mesocorticolimbic dopamine (DA) functioning in
samples with major depressive disorder. The purpose of this
study was to examine linkages between striatal DA, reward
circuitry functioning, anhedonia, and, in an exploratory
fashion, self-reported stress, in a transdiagnostic
anhedonic sample. METHODS: Participants with (n = 25) and
without (n = 12) clinically impairing anhedonia completed
a reward-processing task during simultaneous positron
emission tomography and magnetic resonance (PET-MR) imaging
with [11C]raclopride, a DA D2/D3 receptor antagonist that
selectively binds to striatal DA receptors. RESULTS:
Relative to controls, the anhedonia group exhibited
decreased task-related DA release in the left putamen,
caudate, and nucleus accumbens and right putamen and
pallidum. There were no group differences in task-related
brain activation (fMRI) during reward processing after
correcting for multiple comparisons. General functional
connectivity (GFC) findings revealed blunted fMRI
connectivity between PET-derived striatal seeds and target
regions in the anhedonia group. Associations were identified
between anhedonia severity and the magnitude of task-related
DA release to rewards in the left putamen, but not
mesocorticolimbic GFC. CONCLUSIONS: Results provide evidence
for reduced striatal DA functioning during reward processing
and blunted mesocorticolimbic network functional
connectivity in a transdiagnostic sample with clinically
significant anhedonia.},
Doi = {10.1016/j.pscychresns.2023.111660},
Key = {fds371266}
}
@article{fds370628,
Author = {Cernasov, PM and Kinard, JL and Walsh, E and Kelley, L and Phillips, R and Pisoni, A and Arnold, M and Lowery, SC and Ammirato, M and Nagy, GA and Oliver, JA and Haworth, K and Daughters, SB and Dichter, GS and Smoski,
M},
Title = {Parsing within & between-person dynamics of therapy homework
completion and clinical symptoms in two cognitive behavioral
treatments for adults with anhedonia.},
Journal = {Behav Res Ther},
Volume = {166},
Pages = {104322},
Year = {2023},
Month = {July},
Abstract = {OBJECTIVE: Homework is a key theoretical component of
cognitive-behavioral therapies, however, the effects of
homework on clinical outcomes have largely been evaluated
between-persons rather than within-persons. METHODS: The
effects of homework completion on treatment response were
examined in a randomized trial comparing Behavioral
Activation Treatment for Anhedonia (BATA, n = 38), a novel
psychotherapy, to Mindfulness-Based Cognitive Therapy (MBCT,
n=35). The primary endpoint was consummatory reward
sensitivity, measured weekly by the Snaith Hamilton Pleasure
Scale (SHAPS), up to 15 weeks. Multilevel models evaluated
change in SHAPS scores over time and the effects of
clinician-reported and participant-reported homework.
RESULTS: BATA and MBCT resulted in significant, equivalent
reductions in SHAPS scores. Unexpectedly, participants who
completed greater mean total amounts of homework did not
improve at a faster rate (i.e., no between-person effect).
However, sessions with greater than average
participant-reported homework completion were associated
with greater than average reductions in SHAPS scores (i.e.,
a within-person effect). For clinician-reported homework,
this effect was only evident within the BATA condition.
CONCLUSION: This study shows psychotherapy homework
completion relates to symptomatic improvement in
cognitive-behavioral treatments for anhedonia when
session-to-session changes are examined within-person. On
the contrary, we found no evidence that total homework
completion predicted greater improvements between-person.
When possible, psychotherapy researchers should evaluate
their constructs of interest across multiple sessions (not
just pre/post) to allow more direct tests of hypotheses
predicted by theoretical models of individual change
processes.},
Doi = {10.1016/j.brat.2023.104322},
Key = {fds370628}
}
@article{fds370314,
Author = {Phillips, R and Walsh, E and Jensen, T and Nagy, G and Kinard, J and Cernasov, P and Smoski, M and Dichter, G},
Title = {Longitudinal associations between perceived stress and
anhedonia during psychotherapy.},
Journal = {J Affect Disord},
Volume = {330},
Pages = {206-213},
Year = {2023},
Month = {June},
Abstract = {BACKGROUND: Chronic stress alters reward sensitivity and
contributes to the emergence of anhedonia. In clinical
samples, the perception of stress is a strong predictor of
anhedonia. While there is substantial evidence demonstrating
psychotherapy reduces perceived stress, little is known
regarding the effects of treatment-related decreases in
perceived stress on anhedonia. METHODS: The current study
investigated reciprocal relations between perceived stress
and anhedonia using a cross-lagged panel model approach in a
15-week clinical trial examining the effects of Behavioral
Activation Treatment for Anhedonia (BATA), a novel
psychotherapy to treat anhedonia, compared to a
Mindfulness-Based Cognitive Therapy (MBCT) comparison
intervention (ClinicalTrials.gov Identifiers NCT02874534 and
NCT04036136). RESULTS: Treatment completers (n = 72)
experienced significant reductions in anhedonia
(M = -8.94, SD = 5.66) on the Snaith-Hamilton Pleasure
Scale (t(71) = 13.39, p < .0001), and significant
reductions in perceived stress (M = -3.71, SD = 3.88) on
the Perceived Stress Scale (t(71) = 8.11, p < .0001)
following treatment. Across all treatment-seeking
participants (n = 87), a longitudinal autoregressive
cross-lagged model revealed significant paths showing that
higher levels of perceived stress at treatment Week 1
predicted reductions in anhedonia at treatment Week 4; lower
levels of perceived stress at Week 8 predicted reductions in
anhedonia at Week 12. Anhedonia did not significantly
predict perceived stress at any stage of treatment.
CONCLUSIONS: This study showed specific timing and
directional effects of perceived stress on anhedonia during
psychotherapy treatment. Individuals with relatively high
perceived stress at the start of treatment were more likely
to report relatively lower anhedonia a few weeks into
treatment. At mid-treatment, individuals with low perceived
stress were more likely to report lower anhedonia towards
the end of treatment. These results demonstrate that early
treatment components reduce perceived stress, thus allowing
for downstream changes in hedonic functioning during
mid-late treatment. The findings presented here suggest it
will be critically important for future clinical trials
evaluating novel interventions for anhedonia to measure
stress levels repeatedly, as an important mechanism of
change. TRIAL NAME: Development of a Novel Transdiagnostic
Intervention for Anhedonia - R61 Phase. TRIAL URL:
https://clinicaltrials.gov/ct2/show/NCT02874534. TRIAL
REGISTRATION NUMBER: NCT02874534.},
Doi = {10.1016/j.jad.2023.03.011},
Key = {fds370314}
}
@article{fds367699,
Author = {Diehl, JM and Smoski, MJ and Zimmerman, M},
Title = {Emotion regulation difficulties link trait resilience and
symptoms of depression and anxiety in psychiatric
outpatients.},
Journal = {Ann Clin Psychiatry},
Volume = {34},
Number = {4},
Pages = {245-253},
Year = {2022},
Month = {November},
Abstract = {BACKGROUND: Despite negative associations of trait
resilience with depression and anxiety symptoms, the
mechanisms by which resilience may buffer against these
symptoms remain underexplored. This study investigated
emotion regulation difficulties as a potential link in the
relationship between trait resilience and depression and
anxiety severity in psychiatric outpatients (N = 353).
METHODS: Participants diagnosed with primary depression or
anxiety disorders were evaluated prior to treatment
initiation with the Connor-Davidson Resilience Scale,
Difficulties in Emotion Regulation Scale (DERS), Clinically
Useful Depression Outcome Scale (CUDOS), and Clinically
Useful Anxiety Outcome Scale (CUXOS). RESULTS: In the
depression sample, the effect of resilience on CUDOS scores
was fully mediated by total DERS scores. In the anxiety
sample, the effect of resilience on CUXOS scores was
partially mediated by total DERS scores. Exploratory
parallel mediation analyses showed only the DERS subscale
strategies had a significant effect on CUDOS scores, while
only goals had a significant effect on CUXOS scores.
CONCLUSIONS: Emotion regulation difficulties are a mediator
of trait resilience in psychiatric outpatients. For patients
seeking treatment for depression, difficulties with
accessing emotion regulation strategies may be particularly
relevant, while difficulties meeting one's goals may be most
relevant for patients seeking treatment for
anxiety.},
Doi = {10.12788/acp.0086},
Key = {fds367699}
}
@article{fds361834,
Author = {Neacsiu, AD and Beynel, L and Graner, JL and Szabo, ST and Appelbaum,
LG and Smoski, MJ and LaBar, KS},
Title = {Enhancing cognitive restructuring with concurrent
fMRI-guided neurostimulation for emotional dysregulation-A
randomized controlled trial.},
Journal = {J Affect Disord},
Volume = {301},
Pages = {378-389},
Year = {2022},
Month = {March},
Abstract = {BACKGROUND: Transdiagnostic clinical emotional dysregulation
is a key component of many mental health disorders and
offers an avenue to address multiple disorders with one
transdiagnostic treatment. In the current study, we pilot an
intervention that combines a one-time teaching and practice
of cognitive restructuring (CR) with repetitive transcranial
magnetic stimulation (rTMS), targeted based on functional
magnetic resonance imaging (fMRI). METHODS: Thirty-seven
clinical adults who self-reported high emotional
dysregulation were enrolled in this randomized,
double-blind, placebo-controlled trial. fMRI was collected
as participants were reminded of lifetime stressors and
asked to downregulate their distress using CR tactics. fMRI
BOLD data were analyzed to identify the cluster of voxels
within the left dorsolateral prefrontal cortex (dlPFC) with
the highest activation when participants attempted to
downregulate, versus passively remember, distressing
memories. Participants underwent active or sham rTMS (10 Hz)
over the left dlPFC target while practicing CR following
emotional induction using recent autobiographical stressors.
RESULTS: Receiving active versus sham rTMS led to
significantly higher high frequency heart rate variability
during regulation, lower regulation duration during the
intervention, and higher likelihood to use CR during the
week following the intervention. There were no differences
between conditions when administering neurostimulation alone
without the CR skill and compared to sham. Participants in
the sham versus active condition experienced less distress
the week after the intervention. There were no differences
between conditions at the one-month follow up. CONCLUSION:
This study demonstrated that combining active rTMS with
emotion regulation training for one session significantly
enhances emotion regulation and augments the impact of
training for as long as a week. These findings are a
promising step towards a combined intervention for
transdiagnostic emotion dysregulation.},
Doi = {10.1016/j.jad.2022.01.053},
Key = {fds361834}
}
@article{fds350142,
Author = {Brown, MM and Arigo, D and Wolever, RQ and Smoski, MJ and Hall, MH and Brantley, JG and Greeson, JM},
Title = {Do gender, anxiety, or sleep quality predict
mindfulness-based stress reduction outcomes?},
Journal = {J Health Psychol},
Volume = {26},
Number = {13},
Pages = {2656-2662},
Year = {2021},
Month = {November},
Abstract = {Although mindfulness-based stress reduction (MBSR) can
improve health and well-being, less is known about factors
that predict outcomes. This prospective observational study
examined gender and baseline anxiety and sleep quality as
predictors of change in emotion regulation and stress
symptoms following an 8-week MBSR program. Women and men
reported similar improvement in stress symptoms and
cognitive reappraisal, whereas men improved more in emotion
suppression. Individuals with higher anxiety and worse sleep
pre-treatment benefited most in terms of decreased stress.
Evaluating pre-treatment characteristics could help
determine optimal candidates for MBSR training, and could
optimize outcomes for both women and men.},
Doi = {10.1177/1359105320931186},
Key = {fds350142}
}
@article{fds358708,
Author = {Pizzagalli, DA and Smoski, M and Ang, Y-S and Whitton, AE and Sanacora,
G and Mathew, SJ and Nurnberger, J and Lisanby, SH and Iosifescu, DV and Murrough, JW and Yang, H and Weiner, RD and Calabrese, JR and Goodman,
W and Potter, WZ and Krystal, AD},
Title = {Correction to: Selective kappa-opioid antagonism ameliorates
anhedonic behavior: evidence from the Fast-fail Trial in
Mood and Anxiety Spectrum Disorders (FAST-MAS).},
Journal = {Neuropsychopharmacology},
Volume = {46},
Number = {12},
Pages = {2224},
Year = {2021},
Month = {November},
Doi = {10.1038/s41386-021-01145-9},
Key = {fds358708}
}
@article{fds358376,
Author = {Pisoni, A and Davis, SW and Smoski, M},
Title = {Neural signatures of saliency-mapping in anhedonia: A
narrative review.},
Journal = {Psychiatry Res},
Volume = {304},
Pages = {114123},
Year = {2021},
Month = {October},
Abstract = {Anhedonia is the loss of pleasure or motivation to engage in
previously enjoyable activities, and is a transdiagnostic
symptom associated with significant clinical impairment.
Anhedonia is implicated in several different psychiatric
disorders, presenting a promising opportunity for
transdiagnostic treatment. Thus, developing targeted
treatments for anhedonia is of critical importance for
population mental health. An important first step in doing
so is establishing a thorough understanding of the neural
correlates of anhedonia. The Triple Network Model of
Psychopathology provides a frame for how brain activity may
go awry in anhedonia, specifically in the context of
Salience Network (SN) function (i.e., saliency-mapping). We
present a narrative review examining saliency-mapping as it
relates to anhedonia severity in depressed and
transdiagnostic adult samples. Results revealed increased
anhedonia to be associated with hyperactivity of the SN at
rest and in the context of negative stimuli, as well as a
global lack of SN engagement in the context of positive
stimuli. Potential treatments for anhedonia are placed
within this model, and future directions for research are
discussed.},
Doi = {10.1016/j.psychres.2021.114123},
Key = {fds358376}
}
@article{fds357343,
Author = {Cernasov, P and Walsh, EC and Kinard, JL and Kelley, L and Phillips, R and Pisoni, A and Eisenlohr-Moul, TA and Arnold, M and Lowery, SC and Ammirato, M and Truong, K and Nagy, GA and Oliver, JA and Haworth, K and Smoski, M and Dichter, GS},
Title = {Multilevel growth curve analyses of behavioral activation
for anhedonia (BATA) and mindfulness-based cognitive therapy
effects on anhedonia and resting-state functional
connectivity: Interim results of a randomized
trial✰.},
Journal = {J Affect Disord},
Volume = {292},
Pages = {161-171},
Year = {2021},
Month = {September},
Abstract = {BACKGROUND: The neural mechanisms associated with anhedonia
treatment response are poorly understood. Additionally, no
study has investigated changes in resting-state functional
connectivity (rsFC) accompanying psychosocial treatment for
anhedonia. METHODS: We evaluated a novel psychotherapy,
Behavioral Activation Therapy for Anhedonia (BATA, n = 38)
relative to Mindfulness-Based Cognitive Therapy (MBCT,
n = 35) in a medication-free, transdiagnostic, anhedonic
sample in a parallel randomized controlled trial.
Participants completed up to 15 sessions of therapy and up
to four 7T MRI scans before, during, and after treatment
(n = 185 scans). Growth curve models estimated change over
time in anhedonia and in rsFC using average
region-of-interest (ROI)-to-ROI connectivity within the
default mode network (DMN), frontoparietal network (FPN),
salience network, and reward network. Changes in rsFC from
pre- to post-treatment were further evaluated using
whole-network seed-to-voxel and ROI-to-ROI edgewise
analyses. RESULTS: Growth curve models showed significant
reductions in anhedonia symptoms and in average rsFC within
the DMN and FPN over time, across BATA and MBCT. There were
no differences in anhedonia reductions between treatments.
Within-person, changes in average rsFC were unrelated to
changes in anhedonia. Between-person, higher than average
FPN rsFC was related to less anhedonia across timepoints.
Seed-to-voxel and edgewise rsFC analyses corroborated
reductions within the DMN and between the DMN and FPN over
time, across the sample. CONCLUSIONS: Reductions in rsFC
within the DMN, FPN, and between these networks co-occurred
with anhedonia improvement across two psychosocial
treatments for anhedonia. Future anhedonia clinical trials
with a waitlist control group should disambiguate treatment
versus time-related effects on rsFC.},
Doi = {10.1016/j.jad.2021.05.054},
Key = {fds357343}
}
@article{fds350141,
Author = {Schuette, SA and Zucker, NL and Smoski, MJ},
Title = {Do interoceptive accuracy and interoceptive sensibility
predict emotion regulation?},
Journal = {Psychol Res},
Volume = {85},
Number = {5},
Pages = {1894-1908},
Year = {2021},
Month = {July},
Abstract = {INTRODUCTION: Interoception refers to awareness,
interpretation, and integration of sensations in the body.
While interoceptive accuracy has long been regarded as a
core component of emotional experience, less is known about
the relationship of interoceptive accuracy and related
facets of interoception to emotion regulation deficits. This
study explores how interoceptive accuracy and interoceptive
sensibility relate to emotion regulation in a non-clinical
sample. METHODS: Undergraduate participants completed a
heartbeat perception task and the Multidimensional
Assessment of Interoceptive Awareness (Noticing and Body
Listening sub-scales), and rated their confidence in
performance on the heartbeat perception task. Participants
also completed self-report measures of emotional awareness
and regulation (Profile of Emotional Competence,
intrapersonal emotion identification and emotion regulation
sub-scales), and rated their use of different coping
strategies (Brief COPE). RESULTS: Noticing predicted emotion
identification, emotion regulation, and the use of adaptive
but not maladaptive coping strategies. Heartbeat perception
accuracy did not significantly contribute to the prediction
of any outcome variables. DISCUSSION: Future work is needed
to extend these findings to clinical populations. The
results from this study support the use of interoceptive
training interventions to promote emotional
wellbeing.},
Doi = {10.1007/s00426-020-01369-2},
Key = {fds350141}
}
@article{fds351450,
Author = {Pizzagalli, DA and Smoski, M and Ang, Y-S and Whitton, AE and Sanacora,
G and Mathew, SJ and Nurnberger, J and Lisanby, SH and Iosifescu, DV and Murrough, JW and Yang, H and Weiner, RD and Calabrese, JR and Goodman,
W and Potter, WZ and Krystal, AD},
Title = {Selective kappa-opioid antagonism ameliorates anhedonic
behavior: evidence from the Fast-fail Trial in Mood and
Anxiety Spectrum Disorders (FAST-MAS).},
Journal = {Neuropsychopharmacology},
Volume = {45},
Number = {10},
Pages = {1656-1663},
Year = {2020},
Month = {September},
Abstract = {Anhedonia remains a major clinical issue for which there is
few effective interventions. Untreated or poorly controlled
anhedonia has been linked to worse disease course and
increased suicidal behavior across disorders. Taking a
proof-of-mechanism approach under the auspices of the
National Institute of Mental Health FAST-FAIL initiative, we
were the first to show that, in a transdiagnostic sample
screened for elevated self-reported anhedonia, 8 weeks of
treatment with a kappa-opioid receptor (KOR) antagonist
resulted in significantly higher reward-related activation
in one of the core hubs of the brain reward system (the
ventral striatum), better reward learning in the
Probabilistic Reward Task (PRT), and lower anhedonic
symptoms, relative to 8 weeks of placebo. Here, we performed
secondary analyses of the PRT data to investigate the
putative effects of KOR antagonism on anhedonic behavior
with more precision by using trial-level model-based
Bayesian computational modeling and probability analyses. We
found that, relative to placebo, KOR antagonism resulted in
significantly higher learning rate (i.e., ability to learn
from reward feedback) and a more sustained preference toward
the more frequently rewarded stimulus, but unaltered reward
sensitivity (i.e., the hedonic response to reward feedback).
Collectively, these findings provide novel evidence that in
a transdiagnostic sample characterized by elevated
anhedonia, KOR antagonism improved the ability to modulate
behavior as a function of prior rewards. Together with
confirmation of target engagement in the primary report
(Krystal et al., Nat Med, 2020), the current findings
suggest that further transdiagnostic investigation of KOR
antagonism for anhedonia is warranted.},
Doi = {10.1038/s41386-020-0738-4},
Key = {fds351450}
}
@article{fds349355,
Author = {Krystal, AD and Pizzagalli, DA and Smoski, M and Mathew, SJ and Nurnberger, J and Lisanby, SH and Iosifescu, D and Murrough, JW and Yang, H and Weiner, RD and Calabrese, JR and Sanacora, G and Hermes, G and Keefe, RSE and Song, A and Goodman, W and Szabo, ST and Whitton, AE and Gao, K and Potter, WZ},
Title = {A randomized proof-of-mechanism trial applying the
'fast-fail' approach to evaluating κ-opioid antagonism as a
treatment for anhedonia.},
Journal = {Nat Med},
Volume = {26},
Number = {5},
Pages = {760-768},
Year = {2020},
Month = {May},
Abstract = {The National Institute of Mental Health (NIMH) 'fast-fail'
approach seeks to improve too-often-misleading early-phase
drug development methods by incorporating biomarker-based
proof-of-mechanism (POM) testing in phase 2a. This first
comprehensive application of the fast-fail approach
evaluated the potential of κ-opioid receptor (KOR)
antagonism for treating anhedonia with a POM study
determining whether robust target engagement favorably
impacts the brain circuitry hypothesized to mediate clinical
effects. Here we report the results from a multicenter,
8-week, double-blind, placebo-controlled, randomized trial
in patients with anhedonia and a mood or anxiety disorder
(selective KOR antagonist (JNJ-67953964, 10 mg;
n = 45) and placebo (n = 44)). JNJ-67953964
significantly increased functional magnetic resonance
imaging (fMRI) ventral striatum activation during reward
anticipation (primary outcome) as compared to placebo
(baseline-adjusted mean: JNJ-67953964, 0.72
(s.d. = 0.67); placebo, 0.33 (s.d. = 0.68);
F(1,86) = 5.58, P < 0.01; effect size = 0.58
(95% confidence interval, 0.13-0.99)). JNJ-67953964,
generally well tolerated, was not associated with any
serious adverse events. This study supports proceeding with
assessment of the clinical impact of target engagement and
serves as a model for implementing the 'fast-fail'
approach.},
Doi = {10.1038/s41591-020-0806-7},
Key = {fds349355}
}
@article{fds343769,
Author = {Nagy, GA and Cernasov, P and Pisoni, A and Walsh, E and Dichter, GS and Smoski, MJ},
Title = {Reward Network Modulation as a Mechanism of Change in
Behavioral Activation.},
Journal = {Behav Modif},
Volume = {44},
Number = {2},
Pages = {186-213},
Year = {2020},
Month = {March},
Abstract = {Behavioral Activation (BA) is a contemporary third-wave
psychosocial treatment approach that emphasizes helping
individuals become more active in ways that are meaningful
to them as a means of improving mood and quality of life. BA
has been designated as a well-established, validated
treatment for depression by the American Psychological
Association following several decades of accumulated
empirical support demonstrating that BA techniques
successfully reduce depression symptoms and produce other
desirable outcomes across a variety of populations and
contexts. The purported mechanism of change underlying BA
treatment lies in increasing activation, which in turn
increases contact with positive reinforcement thereby
reversing the cycle of depression. Current studies are
further investigating how increasing activation and
subsequent contact with mood reinforcers can influence mood
and behavior. Specifically, there is growing evidence that
BA modifies function of reward-related networks in the
brain, and that these changes are associated with clinical
improvement. Herein, we provide a brief history of BA,
describe the primary components of BA treatment, and
describe BA's purported mechanisms of change at behavioral,
neural, and subjective activation levels. We present
limitations as well as gaps in the current state of
knowledge regarding mechanisms of action of
BA.},
Doi = {10.1177/0145445518805682},
Key = {fds343769}
}
@article{fds330051,
Author = {Dardas, LA and Silva, SG and van de Water, B and Vance, A and Smoski,
MJ and Noonan, D and Simmons, LA},
Title = {Psychosocial Correlates of Jordanian Adolescents'
Help-Seeking Intentions for Depression: Findings From a
Nationally Representative School Survey.},
Journal = {J Sch Nurs},
Volume = {35},
Number = {2},
Pages = {117-127},
Year = {2019},
Month = {April},
Abstract = {Little is known about help-seeking for depression among
Jordanian adolescents who are a vulnerable population with
high rates of depressive symptoms and few mental health
services. The purpose of this study was to (1) explore
Jordanian adolescents' helpseeking intentions for depression
and (2) examine whether depression stigma, depression
severity, or their interaction are associated with Jordanian
adolescents' willingness to seek help for depression and the
type of treatment they would seek. In collaboration with the
Jordanian Ministry of Education, we conducted a nationally
representative, school-based survey of adolescents aged
12-17 years ( N = 2,349). One fourth of the adolescents
reported they would not seek professional help for
depression, and those respondents had higher average
depression scores. Among those adolescents willing to seek
help, the most likely sources included family member (57%),
school counselor (46%), psychiatrist (43%), religious leader
(39%), and general health practitioner (28%). Lower stigma
scores were associated with greater likelihood to seek
psychotherapy or visit a psychiatrist, while higher stigma
scores were associated with increased likelihood to seek
help from a school counselor or a family member. Jordanian
adolescents experience significant barriers to seeking
professional help for depression. However, even among
adolescents with greater depression severity and depression
stigma, school counselors were identified as a key resource
for help. These findings suggest that school-based
interventions may fill a critical service need for
adolescents with depression and other mental health
problems. School nurses should be leveraged along with
counselors to address mental health issues in this
vulnerable population.},
Doi = {10.1177/1059840517731493},
Key = {fds330051}
}
@article{fds338576,
Author = {Walsh, EC and Eisenlohr-Moul, TA and Minkel, J and Bizzell, J and Petty,
C and Crowther, A and Carl, H and Smoski, MJ and Dichter,
GS},
Title = {Pretreatment brain connectivity during positive emotion
upregulation predicts decreased anhedonia following
behavioral activation therapy for depression.},
Journal = {J Affect Disord},
Volume = {243},
Pages = {188-192},
Year = {2019},
Month = {January},
Abstract = {BACKGROUND: Neurobiological predictors of antidepressant
response may help guide treatment selection and improve
response rates to available treatments for major depressive
disorder (MDD). Behavioral activation therapy for depression
(BATD) is an evidence-based intervention designed to
ameliorate core symptoms of MDD by promoting sustained
engagement with value-guided, positively-reinforcing
activities. The present study examined pre-treatment
task-based functional brain connectivity as a predictor of
antidepressant response to BATD. METHODS: Thirty-three
outpatients with MDD and 20 nondepressed controls completed
a positive emotion regulation task during fMRI after which
participants with MDD received up to 15 sessions of BATD. We
used generalized psychophysiological interaction analyses to
examine group differences in pre-treatment functional brain
connectivity during intentional upregulation of positive
emotion to positive images. Hierarchical linear models were
used to examine whether group differences in functional
connectivity predicted changes in depression and anhedonia
over the course of BATD. RESULTS: Compared to controls,
participants with MDD exhibited decreased connectivity
between the left middle frontal gyrus and right
temporoparietal regions during upregulation of positive
emotion. Within the MDD group, decreased connectivity of
these regions predicted greater declines in anhedonia
symptoms over treatment. LIMITATIONS: Future studies should
include comparison treatments and longitudinal follow-up to
clarify the unique effects of BATD on neural function and
antidepressant response. CONCLUSIONS: Results are consistent
with previous work showing BATD may be particularly
effective for individuals with greater disturbances in brain
reward network function, but extend these findings to
highlight the importance of frontotemporoparietal
connectivity in targeting symptoms of low motivation and
engagement.},
Doi = {10.1016/j.jad.2018.09.065},
Key = {fds338576}
}
@article{fds340790,
Author = {Krystal, AD and Pizzagalli, DA and Mathew, SJ and Sanacora, G and Keefe,
R and Song, A and Calabrese, J and Goddard, A and Goodman, W and Lisanby,
SH and Smoski, M and Weiner, R and Iosifescu, D and Nurnberger, J and Szabo, S and Murrough, J and Shekhar, A and Potter,
W},
Title = {The first implementation of the NIMH FAST-FAIL approach to
psychiatric drug development.},
Journal = {Nat Rev Drug Discov},
Volume = {18},
Number = {1},
Pages = {82-84},
Year = {2018},
Month = {December},
Doi = {10.1038/nrd.2018.222},
Key = {fds340790}
}
@article{fds336956,
Author = {Dardas, LA and Silva, SG and Scott, J and Gondwe, KW and Smoski, MJ and Noonan, D and Simmons, LA},
Title = {Do beliefs about depression etiologies influence the type
and severity of depression stigma? The case of Arab
adolescents.},
Journal = {Perspect Psychiatr Care},
Volume = {54},
Number = {4},
Pages = {547-556},
Year = {2018},
Month = {October},
Abstract = {PURPOSE: Research has documented that holding certain
etiological beliefs about depression can determine the level
of stigma experienced by individuals with depression. To
date, no studies have yet examined this relationship among
adolescents. Using a sample of Arab adolescents, the purpose
of this study was to describe adolescents' beliefs about the
etiology of depression, and examine whether these beliefs
influence the type and severity of depression stigma.
METHODS: A nationwide school survey was conducted in a
representative sample of Jordanian public and private
schools located in Jordan, a Middle-Eastern Arab country. A
total of 2,349 adolescents aged 12-17 (59% female) completed
and returned an anonymous survey that included measures on
adolescents' sociodemographic and health characteristics,
depression symptoms, depression stigma, and depression
etiological beliefs. An exploratory factor analysis with
principal components analysis (PCA) was used to examine the
factor structure of the Depression Etiological Beliefs
Scale. The stability of the PCA findings was tested using a
cross-validation method. Regression analyses were performed
to examine whether depression etiological beliefs,
depression severity, or their interaction are associated
with depression stigma. RESULTS: Adolescents endorsed
multiple etiological beliefs about depression. The beliefs
in which likely or very likely was most often reported were
stressful events in one's life (72%), social factors (65%),
and one's weak will (56%). On the other hand, the least
reported beliefs were genetic or inherited problems (24%),
chemical imbalance (30%), and punishment for wrong doings
(35%). The interaction between adolescents' depression
severity and depression beliefs significantly predicted
personal stigma. Adolescent sex, age, and region of
residence significantly affected the relationship between
depression beliefs and stigma. CONCLUSIONS: Nurses need to
consider the beliefs and attitudes their patients have
around depression, as these can influence symptom severity,
comprehensive treatment plans, and adherence to provider
recommendations. This study provides a better understanding
of how depression beliefs affect Jordanian adolescents'
attitudes toward depression, which can guide intervention
programs to increase awareness about depression and promote
treatment utilization.},
Doi = {10.1111/ppc.12270},
Key = {fds336956}
}
@article{fds332808,
Author = {Dardas, LA and Silva, SG and Smoski, MJ and Noonan, D and Simmons,
LA},
Title = {Corrigendum to "Personal and Perceived Depression Stigma
among Arab Adolescents: Associations with Depression
Severity and Personal Characteristics" [Archives of
Psychiatric Nursing 31/5 (2017) 499-506].},
Journal = {Arch Psychiatr Nurs},
Volume = {32},
Number = {2},
Pages = {325},
Year = {2018},
Month = {April},
Doi = {10.1016/j.apnu.2018.01.005},
Key = {fds332808}
}
@article{fds332790,
Author = {Dardas, LA and Silva, SG and Smoski, MJ and Noonan, D and Simmons,
LA},
Title = {The prevalence of depressive symptoms among Arab
adolescents: Findings from Jordan.},
Journal = {Public Health Nurs},
Volume = {35},
Number = {2},
Pages = {100-108},
Year = {2018},
Month = {March},
Abstract = {BACKGROUND: The lack of research regarding the current
profile of adolescent depression in the Arab countries in
general, and Jordan in particular, makes it difficult to
design, implement, and disseminate effective interventions
to improve the prevention, diagnosis, and treatment of
adolescent depression in the region. The purpose of this
study was to estimate a national prevalence of depressive
symptoms among adolescents in Jordan, and to identify
characteristics associated with severity of depression.
METHODS: A descriptive, cross-sectional, nationally
representative school survey was utilized. A total of 2,349
Jordanian adolescents aged 12-17 completed and returned the
survey packets, which included the Beck Depression
Inventory-II and measures of sociodemographics and health
history. Participants represented all three regions in the
country, with 34% from the northern (suburban) region, 43%
from the central (urban) region, and 23% from the southern
(rural) region. RESULTS: The majority of the adolescents
were females (59%) and 15-17 years old (67%). Almost 14%
reported having at least one chronic health problem, 15%
reported having a mental health problem, 25% reported having
academic difficulties, 8% reported that they had received a
psychiatric diagnosis, and 22% reported that they had sought
psychological help at some point in the past. The mean total
depression score was 16.3 (SD = 11.2, 95%
CI = 15.8-16.7), with 34% of the sample reporting moderate
to severe depression. Depression was significantly higher
among respondents who were female, ages 14-15 years, and
living in families with low monthly incomes; and who
reported having a chronic health problem, mental health
problem, learning difficulty, a psychiatric diagnosis and/or
seeking previous psychological help. CONCLUSIONS: Our
findings should serve as an alarm, particularly given that
rates of depression in the Arab countries are expected to
increase rapidly in the context of the Arab Spring.
Healthcare providers, researchers, and educators should
focus attention on developing effective and culturally
appropriate screening, prevention, and intervention
approaches using evidence-based guidelines to promote
Jordanian adolescent mental health, particularly for
depression.},
Doi = {10.1111/phn.12363},
Key = {fds332790}
}
@article{fds331886,
Author = {Dardas, LA and Silva, SG and Smoski, MJ and Noonan, D and Simmons,
LA},
Title = {Adolescent Depression in Jordan: Symptoms Profile, Gender
Differences, and the Role of Social Context.},
Journal = {J Psychosoc Nurs Ment Health Serv},
Volume = {56},
Number = {2},
Pages = {44-55},
Year = {2018},
Month = {February},
Abstract = {The influence of gender and other individual and context
characteristics on the prevalence and severity of depressive
symptoms among Jordanian adolescents remains unclear. The
aims of the current study were to: (a) characterize
depressive symptoms profiles for Jordanian adolescents; and
(b) examine gender differences in the type, severity, and
correlates of depressive symptoms. Cross-sectional data were
collected from 2,349 Jordanian adolescents ages 12 to 17
using a nationally representative school survey. The Beck
Depression Inventory-II was used to assess the presence and
severity of depressive symptoms. Female adolescents had
significantly higher mean depression scores (17.9 [SD =
11.6], 95% confidence interval [CI] [17.3, 18.5]) than their
male counterparts (13.8 [SD = 10.2], 95% CI [13.2, 14.5]).
Approximately 41% of girls and 26% of boys reported scores
indicating moderate to severe depression. Sex differences
and socially constructed gender differences need to be
adequately considered in the planning and delivery of mental
health care for adolescent depression. If the risk for
depression is gender-specific, prevention strategies cannot
be gender-neutral. [Journal of Psychosocial Nursing and
Mental Health Services, 56(2), 44-55.].},
Doi = {10.3928/02793695-20171027-04},
Key = {fds331886}
}
@article{fds336958,
Author = {Greeson, JM and Zarrin, H and Smoski, MJ and Brantley, JG and Lynch, TR and Webber, DM and Hall, MH and Suarez, EC and Wolever,
RQ},
Title = {Mindfulness Meditation Targets Transdiagnostic Symptoms
Implicated in Stress-Related Disorders: Understanding
Relationships between Changes in Mindfulness, Sleep Quality,
and Physical Symptoms.},
Journal = {Evid Based Complement Alternat Med},
Volume = {2018},
Pages = {4505191},
Year = {2018},
Abstract = {Mindfulness-Based Stress Reduction (MBSR) is an 8-week
meditation program known to improve anxiety, depression, and
psychological well-being. Other health-related effects, such
as sleep quality, are less well established, as are the
psychological processes associated with therapeutic change.
This prospective, observational study (n = 213) aimed to
determine whether perseverative cognition, indicated by
rumination and intrusive thoughts, and emotion regulation,
measured by avoidance, thought suppression, emotion
suppression, and cognitive reappraisal, partly accounted for
the hypothesized relationship between changes in mindfulness
and two health-related outcomes: sleep quality and
stress-related physical symptoms. As expected, increased
mindfulness following the MBSR program was directly
correlated with decreased sleep disturbance (r = -0.21, p =
0.004) and decreased stress-related physical symptoms (r =
-0.38, p < 0.001). Partial correlations revealed that
pre-post changes in rumination, unwanted intrusive thoughts,
thought suppression, experiential avoidance, emotion
suppression, and cognitive reappraisal each uniquely
accounted for up to 32% of the correlation between the
change in mindfulness and change in sleep disturbance and up
to 30% of the correlation between the change in mindfulness
and change in stress-related physical symptoms. Results
suggest that the stress-reducing effects of MBSR are due, in
part, to improvements in perseverative cognition and emotion
regulation, two "transdiagnostic" mental processes that cut
across stress-related disorders.},
Doi = {10.1155/2018/4505191},
Key = {fds336958}
}
@article{fds326770,
Author = {Dardas, LA and Silva, SG and Smoski, MJ and Noonan, D and Simmons,
LA},
Title = {Personal and Perceived Depression Stigma among Arab
Adolescents: Associations with Depression Severity and
Personal Characteristics.},
Journal = {Arch Psychiatr Nurs},
Volume = {31},
Number = {5},
Pages = {499-506},
Year = {2017},
Month = {October},
Abstract = {BACKGROUND: In Arab communities, the selection, utilization,
and attitudes towards mental health services are
substantially affected by existing mental illness stigma.
However, little is known about how the stigma of depression
manifests among Arab adolescents, which makes it difficult
to design, implement, and disseminate effective anti-stigma
interventions for this vulnerable population. Therefore, the
purpose of this study was to determine levels of depression
stigma among Arab adolescents. The specific aims were to (1)
describe the severity of personal and perceived depression
stigma among Arab adolescents and its relationship to
severity of depression, and (2) determine characteristics
associated with severity of depression stigma among Arab
adolescents. METHODS: This study was conducted in Jordan, a
Middle Eastern Arab country. A nationally representative,
school-based survey was utilized. A total of 2349 Jordanian
adolescents aged 12-17 completed and returned the survey
packets, which included measures on individual
characteristics, depression severity, and depression stigma.
RESULTS: The majority of the adolescents (88%) reported
scores indicating moderate to high depression stigma.
Adolescents reported higher rates of perceived stigma than
personal stigma. Depression stigma was not significantly
associated with severity of depression, but with
adolescent's sex, age, region of residence, parents'
education, and history of mental health problem.
CONCLUSIONS: This is the first Arab study to isolate the
influence of adolescent depression and personal
characteristics on personal and perceived depression
stigmas, and highlight the presence of these distinctions
early in adolescence. Such distinction can inform the design
and implementation of policies and interventions to reduce
both personal and perceived stigma. The study provides
important recommendations on when, how, and why to utilize
school settings for anti-depression stigma
interventions.},
Doi = {10.1016/j.apnu.2017.06.005},
Key = {fds326770}
}
@article{fds323970,
Author = {Keng, S-L and Tan, ELY and Eisenlohr-Moul, TA and Smoski,
MJ},
Title = {Effects of mindfulness, reappraisal, and suppression on sad
mood and cognitive resources.},
Journal = {Behav Res Ther},
Volume = {91},
Pages = {33-42},
Year = {2017},
Month = {April},
Abstract = {The present study investigated the relative effects of
mindfulness, reappraisal and suppression in reducing
sadness, and the extent to which implementation of these
strategies affects cognitive resources in a laboratory
context. A total of 171 Singaporean undergraduate
participants were randomly assigned to receive brief
training in mindfulness, reappraisal, or suppression prior
to undergoing a sad mood induction. Individual adherence to
Asian cultural values was assessed as a potential moderator
of strategy effectiveness. Participants rated their mood and
completed a Color-Word Stroop task before and after mood
regulation instructions. Analyses using multi-level
modelling showed that the suppression condition caused less
robust declines in sadness over time compared to
mindfulness. There was also a nonsignificant trend in which
mindfulness was associated with greater sadness recovery
compared to reappraisal. Suppression resulted in lower
average sadness compared to mindfulness among those high on
Asian cultural values, but not those low on Asian cultural
values. Both mindfulness and reappraisal buffered against
increases in Stroop interference from pre-to post-regulation
compared to suppression. The findings highlight the
advantage of mindfulness as a strategy effective not only in
the regulation of sad mood, but also in the preservation of
cognitive resources in the context of mood
regulation.},
Doi = {10.1016/j.brat.2017.01.006},
Key = {fds323970}
}
@article{fds320766,
Author = {Walsh, E and Carl, H and Eisenlohr-Moul, T and Minkel, J and Crowther,
A and Moore, T and Gibbs, D and Petty, C and Bizzell, J and Smoski, MJ and Dichter, GS},
Title = {Attenuation of Frontostriatal Connectivity During Reward
Processing Predicts Response to Psychotherapy in Major
Depressive Disorder.},
Journal = {Neuropsychopharmacology},
Volume = {42},
Number = {4},
Pages = {831-843},
Year = {2017},
Month = {March},
Abstract = {There are few reliable predictors of response to
antidepressant treatments. In the present investigation, we
examined pretreatment functional brain connectivity during
reward processing as a potential predictor of response to
Behavioral Activation Treatment for Depression (BATD), a
validated psychotherapy that promotes engagement with
rewarding stimuli and reduces avoidance behaviors.
Thirty-three outpatients with major depressive disorder
(MDD) and 20 matched controls completed two runs of the
monetary incentive delay task during functional magnetic
resonance imaging after which participants with MDD received
up to 15 sessions of BATD. Seed-based generalized
psychophysiological interaction analyses focused on
task-based connectivity across task runs, as well as the
attenuation of connectivity from the first to the second run
of the task. The average change in Beck Depression
Inventory-II scores due to treatment was 10.54 points, a
clinically meaningful response. Groups differed in
seed-based functional connectivity among multiple
frontostriatal regions. Hierarchical linear modeling
revealed that improved treatment response to BATD was
predicted by greater connectivity between the left putamen
and paracingulate gyrus during reward anticipation. In
addition, MDD participants with greater attenuation of
connectivity between several frontostriatal seeds, and
midline subcallosal cortex and left paracingulate gyrus
demonstrated improved response to BATD. These findings
indicate that pretreatment frontostriatal functional
connectivity during reward processing is predictive of
response to a psychotherapy modality that promotes improving
approach-related behaviors in MDD. Furthermore, connectivity
attenuation among reward-processing regions may be a
particularly powerful endophenotypic predictor of response
to BATD in MDD.},
Doi = {10.1038/npp.2016.179},
Key = {fds320766}
}
@article{fds352269,
Author = {Smoski, MJ and McClintock, A and Keeling, L},
Title = {Mindfulness Training for Emotional and Cognitive Health in
Late Life},
Journal = {Current Behavioral Neuroscience Reports},
Volume = {3},
Number = {4},
Pages = {301-307},
Year = {2016},
Month = {December},
Abstract = {Purpose of Review: There is a growing interest in
psychosocial interventions that can enhance emotional and
cognitive health in older adults, both to treat
psychopathology and/or cognitive decline and to prolong
optimum functioning in healthy individuals.
Mindfulness-based interventions (MBIs) have been proposed as
an accessible and effective means of promoting emotional and
cognitive health. This article reviews recent clinical
trials of MBIs in older adults. Recent Findings: There is
growing support for MBIs as a means to address mild to
moderate clinical concerns, including depression, anxiety,
sleep, and subjective memory or other cognitive complains
but little evidence that MBIs improve functioning in already
healthy individuals. Summary: MBIs may be effective for
older adults with mild to moderate emotional and cognitive
dysfunction. Future longitudinal work is needed to test if
MBIs are an effective means of prevention of emotional or
cognitive decline.},
Doi = {10.1007/s40473-016-0097-y},
Key = {fds352269}
}
@article{fds319711,
Author = {Carl, H and Walsh, E and Eisenlohr-Moul, T and Minkel, J and Crowther,
A and Moore, T and Gibbs, D and Petty, C and Bizzell, J and Dichter, GS and Smoski, MJ},
Title = {Sustained anterior cingulate cortex activation during reward
processing predicts response to psychotherapy in major
depressive disorder.},
Journal = {J Affect Disord},
Volume = {203},
Pages = {204-212},
Year = {2016},
Month = {October},
Abstract = {BACKGROUND: The purpose of the present investigation was to
evaluate whether pre-treatment neural activation in response
to rewards is a predictor of clinical response to Behavioral
Activation Therapy for Depression (BATD), an empirically
validated psychotherapy that decreases depressive symptoms
by increasing engagement with rewarding stimuli and reducing
avoidance behaviors. METHODS: Participants were 33
outpatients with major depressive disorder (MDD) and 20
matched controls. We examined group differences in
activation, and the capacity to sustain activation, across
task runs using functional magnetic resonance imaging (fMRI)
and the monetary incentive delay (MID) task. Hierarchical
linear modeling was used to investigate whether
pre-treatment neural responses predicted change in
depressive symptoms over the course of BATD treatment.
RESULT: MDD and Control groups differed in sustained
activation during reward outcomes in the right nucleus
accumbens, such that the MDD group experienced a significant
decrease in activation in this region from the first to
second task run relative to controls. Pretreatment anhedonia
severity and pretreatment task-related reaction times were
predictive of response to treatment. Furthermore, sustained
activation in the anterior cingulate cortex during reward
outcomes predicted response to psychotherapy; patients with
greater sustained activation in this region were more
responsive to BATD treatment. LIMITATION: The current study
only included a single treatment condition, thus it unknown
whether these predictors of treatment response are specific
to BATD or psychotherapy in general. CONCLUSION: Findings
add to the growing body of literature suggesting that the
capacity to sustain neural responses to rewards may be a
critical endophenotype of MDD.},
Doi = {10.1016/j.jad.2016.06.005},
Key = {fds319711}
}
@article{fds323548,
Author = {Keng, S-L and Seah, STH and Tong, EMW and Smoski,
M},
Title = {Effects of brief mindful acceptance induction on implicit
dysfunctional attitudes and concordance between implicit and
explicit dysfunctional attitudes.},
Journal = {Behav Res Ther},
Volume = {83},
Pages = {1-10},
Year = {2016},
Month = {August},
Abstract = {Mindfulness-based interventions have been shown to be
effective in alleviating depressive symptoms. While much
work has examined the effects of mindfulness training on
subjective symptoms and experiences, and less is known
regarding whether mindfulness training may alter relatively
uncontrollable cognitive processes associated with depressed
mood, particularly implicit dysfunctional attitudes. The
present study examined the effects of a brief mindful
acceptance induction on implicit dysfunctional attitudes and
degree of concordance between implicit and explicit
dysfunctional attitudes in the context of sad mood. A total
of 79 adult participants with elevated depressive symptoms
underwent an autobiographical mood induction procedure
before being randomly assigned to mindful acceptance or
thought wandering inductions. Results showed that the effect
of mindful acceptance on implicit dysfunctional attitude was
significantly moderated by trait mindfulness. Participants
high on trait mindfulness demonstrated significant
improvements in implicit dysfunctional attitudes following
the mindful acceptance induction. Those low on trait
mindfulness demonstrated significantly worse implicit
dysfunctional attitudes following the induction.
Significantly greater levels of concordance between implicit
and explicit dysfunctional attitudes were observed in the
mindful acceptance condition versus the thought wandering
condition. The findings highlight changes in implicit
dysfunctional attitudes and improvements in self-concordance
as two potential mechanisms underlying the effects of
mindfulness-based interventions.},
Doi = {10.1016/j.brat.2016.05.004},
Key = {fds323548}
}
@article{fds323549,
Author = {Kaiser, RH and Whitfield-Gabrieli, S and Dillon, DG and Goer, F and Beltzer, M and Minkel, J and Smoski, M and Dichter, G and Pizzagalli,
DA},
Title = {Dynamic Resting-State Functional Connectivity in Major
Depression.},
Journal = {Neuropsychopharmacology},
Volume = {41},
Number = {7},
Pages = {1822-1830},
Year = {2016},
Month = {June},
Abstract = {Major depressive disorder (MDD) is characterized by abnormal
resting-state functional connectivity (RSFC), especially in
medial prefrontal cortical (MPFC) regions of the default
network. However, prior research in MDD has not examined
dynamic changes in functional connectivity as networks form,
interact, and dissolve over time. We compared unmedicated
individuals with MDD (n=100) to control participants (n=109)
on dynamic RSFC (operationalized as SD in RSFC over a series
of sliding windows) of an MPFC seed region during a
resting-state functional magnetic resonance imaging scan.
Among participants with MDD, we also investigated the
relationship between symptom severity and RSFC. Secondary
analyses probed the association between dynamic RSFC and
rumination. Results showed that individuals with MDD were
characterized by decreased dynamic (less variable) RSFC
between MPFC and regions of parahippocampal gyrus within the
default network, a pattern related to sustained positive
connectivity between these regions across sliding windows.
In contrast, the MDD group exhibited increased dynamic (more
variable) RSFC between MPFC and regions of insula, and
higher severity of depression was related to increased
dynamic RSFC between MPFC and dorsolateral prefrontal
cortex. These patterns of highly variable RSFC were related
to greater frequency of strong positive and negative
correlations in activity across sliding windows. Secondary
analyses indicated that increased dynamic RSFC between MPFC
and insula was related to higher levels of recent
rumination. These findings provide initial evidence that
depression, and ruminative thinking in depression, are
related to abnormal patterns of fluctuating communication
among brain systems involved in regulating attention and
self-referential thinking.},
Doi = {10.1038/npp.2015.352},
Key = {fds323549}
}
@article{fds319712,
Author = {Keng, SL and Smoski, MJ and Robins, CJ},
Title = {Effects of Mindful Acceptance and Reappraisal Training on
Maladaptive Beliefs About Rumination},
Journal = {Mindfulness},
Volume = {7},
Number = {2},
Pages = {493-503},
Publisher = {Springer Nature},
Year = {2016},
Month = {April},
Abstract = {The present study examined the relative effects of mindful
acceptance and reappraisal on metacognitive attitudes and
beliefs in relation to rumination and negative experiences.
A small but growing literature has compared the effects of
these strategies on immediate emotional experience, but
little work has examined the broader, metacognitive impact
of these strategies, such as maladaptive beliefs about
rumination. One hundred and twenty-nine participants who
reported elevated symptoms of depression were randomly
assigned to receive brief training in mindful acceptance,
reappraisal, or no training prior to undergoing an
autobiographical sad mood induction. Participants rated
their beliefs in relation to rumination and negative
experiences before and after instructions to engage in mood
regulation. Results showed that relative to reappraisal or
no training, training in mindful acceptance resulted in
greater decreases in maladaptive beliefs about rumination.
The study suggests that training in mindful acceptance
promotes beneficial changes in metacognitive attitudes and
beliefs relevant to depression, and contributes to a greater
understanding of the mechanisms through which
mindfulness-based interventions lead to positive
outcomes.},
Doi = {10.1007/s12671-015-0480-x},
Key = {fds319712}
}
@article{fds276255,
Author = {Richey, JA and Damiano, CR and Sabatino, A and Rittenberg, A and Petty,
C and Bizzell, J and Voyvodic, J and Heller, AS and Coffman, MC and Smoski,
M and Davidson, RJ and Dichter, GS},
Title = {Neural Mechanisms of Emotion Regulation in Autism Spectrum
Disorder.},
Journal = {J Autism Dev Disord},
Volume = {45},
Number = {11},
Pages = {3409-3423},
Year = {2015},
Month = {November},
ISSN = {0162-3257},
Abstract = {Autism spectrum disorder (ASD) is characterized by high
rates of comorbid internalizing and externalizing disorders.
One mechanistic account of these comorbidities is that ASD
is characterized by impaired emotion regulation (ER) that
results in deficits modulating emotional responses. We
assessed neural activation during cognitive reappraisal of
faces in high functioning adults with ASD. Groups did not
differ in looking time, pupilometry, or subjective ratings
of faces during reappraisal. However, instructions to
increase positive and negative emotional responses resulted
in less increase in nucleus accumbens and amygdala
activations (respectively) in the ASD group, and both
regulation instructions resulted in less change in
dorsolateral prefrontal cortex activation in the ASD group.
Results suggest a potential mechanistic account of impaired
ER in ASD.},
Doi = {10.1007/s10803-015-2359-z},
Key = {fds276255}
}
@article{fds276260,
Author = {Smoski, MJ and Keng, S-L and Ji, JL and Moore, T and Minkel, J and Dichter,
GS},
Title = {Neural indicators of emotion regulation via acceptance vs
reappraisal in remitted major depressive
disorder.},
Journal = {Soc Cogn Affect Neurosci},
Volume = {10},
Number = {9},
Pages = {1187-1194},
Year = {2015},
Month = {September},
ISSN = {1749-5016},
Abstract = {Mood disorders are characterized by impaired emotion
regulation abilities, reflected in alterations in
frontolimbic brain functioning during regulation. However,
little is known about differences in brain function when
comparing regulatory strategies. Reappraisal and emotional
acceptance are effective in downregulating negative affect,
and are components of effective depression psychotherapies.
Investigating neural mechanisms of reappraisal vs emotional
acceptance in remitted major depressive disorder (rMDD) may
yield novel mechanistic insights into depression risk and
prevention. Thirty-seven individuals (18 rMDD, 19 controls)
were assessed during a functional magnetic resonance imaging
task requiring reappraisal, emotional acceptance or no
explicit regulation while viewing sad images. Lower negative
affect was reported following reappraisal than acceptance,
and was lower following acceptance than no explicit
regulation. In controls, the acceptance > reappraisal
contrast revealed greater activation in left insular cortex
and right prefrontal gyrus, and less activation in several
other prefrontal regions. Compared with controls, the rMDD
group had greater paracingulate and right midfrontal gyrus
(BA 8) activation during reappraisal relative to acceptance.
Compared with reappraisal, acceptance is associated with
activation in regions linked to somatic and emotion
awareness, although this activation is associated with less
reduction in negative affect. Additionally, a history of MDD
moderated these effects.},
Doi = {10.1093/scan/nsv003},
Key = {fds276260}
}
@article{fds276261,
Author = {Crowther, A and Smoski, MJ and Minkel, J and Moore, T and Gibbs, D and Petty, C and Bizzell, J and Schiller, CE and Sideris, J and Carl, H and Dichter, GS},
Title = {Resting-state connectivity predictors of response to
psychotherapy in major depressive disorder.},
Journal = {Neuropsychopharmacology},
Volume = {40},
Number = {7},
Pages = {1659-1673},
Year = {2015},
Month = {June},
ISSN = {0893-133X},
Abstract = {Despite the heterogeneous symptom presentation and complex
etiology of major depressive disorder (MDD), functional
neuroimaging studies have shown with remarkable consistency
that dysfunction in mesocorticolimbic brain systems are
central to the disorder. Relatively less research has
focused on the identification of biological markers of
response to antidepressant treatment that would serve to
improve the personalized delivery of empirically supported
antidepressant interventions. In the present study, we
investigated whether resting-state functional brain
connectivity (rs-fcMRI) predicted response to Behavioral
Activation Treatment for Depression, an empirically
validated psychotherapy modality designed to increase
engagement with rewarding stimuli and reduce avoidance
behaviors. Twenty-three unmedicated outpatients with MDD and
20 matched nondepressed controls completed rs-fcMRI scans
after which the MDD group received an average of 12 sessions
of psychotherapy. The mean change in Beck Depression
Inventory-II scores after psychotherapy was 12.04 points, a
clinically meaningful response. Resting-state neuroimaging
data were analyzed with a seed-based approach to investigate
functional connectivity with four canonical resting-state
networks: the default mode network, the dorsal attention
network, the executive control network, and the salience
network. At baseline, the MDD group was characterized by
relative hyperconnectivity of multiple regions with
precuneus, anterior insula, dorsal anterior cingulate cortex
(dACC), and left dorsolateral prefrontal cortex seeds and by
relative hypoconnectivity with intraparietal sulcus,
anterior insula, and dACC seeds. Additionally, connectivity
of the precuneus with the left middle temporal gyrus and
connectivity of the dACC with the parahippocampal gyrus
predicted the magnitude of pretreatment MDD symptoms.
Hierarchical linear modeling revealed that response to
psychotherapy in the MDD group was predicted by pretreatment
connectivity of the right insula with the right middle
temporal gyrus and the left intraparietal sulcus with the
orbital frontal cortex. These results add to the nascent
body of literature investigating pretreatment rs-fcMRI
predictors of antidepressant treatment response and is the
first study to examine rs-fcMRI predictors of response to
psychotherapy.},
Doi = {10.1038/npp.2015.12},
Key = {fds276261}
}
@article{fds276259,
Author = {Greeson, JM and Smoski, MJ and Suarez, EC and Brantley, JG and Ekblad,
AG and Lynch, TR and Wolever, RQ},
Title = {Decreased symptoms of depression after mindfulness-based
stress reduction: potential moderating effects of
religiosity, spirituality, trait mindfulness, sex, and
age.},
Journal = {J Altern Complement Med},
Volume = {21},
Number = {3},
Pages = {166-174},
Year = {2015},
Month = {March},
ISSN = {1075-5535},
Abstract = {OBJECTIVE: Mindfulness-based stress reduction (MBSR) is a
secular meditation training program that reduces depressive
symptoms. Little is known, however, about the degree to
which a participant's spiritual and religious background, or
other demographic characteristics associated with risk for
depression, may affect the effectiveness of MBSR. Therefore,
this study tested whether individual differences in
religiosity, spirituality, motivation for spiritual growth,
trait mindfulness, sex, and age affect MBSR effectiveness.
METHODS: As part of an open trial, multiple regression was
used to analyze variation in depressive symptom outcomes
among 322 adults who enrolled in an 8-week, community-based
MBSR program. RESULTS: As hypothesized, depressive symptom
severity decreased significantly in the full study sample
(d=0.57; p<0.01). After adjustment for baseline symptom
severity, moderation analyses revealed no significant
differences in the change in depressive symptoms following
MBSR as a function of spirituality, religiosity, trait
mindfulness, or demographic variables. Paired t tests found
consistent, statistically significant (p<0.01) reductions in
depressive symptoms across all subgroups by religious
affiliation, intention for spiritual growth, sex, and
baseline symptom severity. After adjustment for baseline
symptom scores, age, sex, and religious affiliation, a
significant proportion of variance in post-MBSR depressive
symptoms was uniquely explained by changes in both
spirituality (β=-0.15; p=0.006) and mindfulness (β=-0.17;
p<0.001). CONCLUSIONS: These findings suggest that MBSR, a
secular meditation training program, is associated with
improved depressive symptoms regardless of affiliation with
a religion, sense of spirituality, trait level of
mindfulness before MBSR training, sex, or age. Increases in
both mindfulness and daily spiritual experiences uniquely
explained improvement in depressive symptoms.},
Doi = {10.1089/acm.2014.0285},
Key = {fds276259}
}
@article{fds276262,
Author = {Dichter, GS and Gibbs, D and Smoski, MJ},
Title = {A systematic review of relations between resting-state
functional-MRI and treatment response in major depressive
disorder.},
Journal = {J Affect Disord},
Volume = {172},
Pages = {8-17},
Year = {2015},
Month = {February},
ISSN = {0165-0327},
Abstract = {BACKGROUND: Resting-state functional magnetic resonance
imaging (fMRI) is a promising predictor of treatment
response in major depressive disorder (MDD). METHODS: A
search for papers published in English was conducted using
PubMed with the following words: depression, treatment,
resting-state, connectivity, and fMRI. Findings from 21
studies of relations between resting-state fMRI and
treatment response in MDD are presented, and common findings
and themes are discussed. RESULTS: The use of resting-state
fMRI in research on MDD treatment response has yielded a
number of consistent findings that provide a basis for
understanding the potential mechanisms of action of
antidepressant treatment response. These included (1)
associations between response to antidepressant medications
and increased functional connectivity between frontal and
limbic brain regions, possibly resulting in greater
inhibitory control over neural circuits that process
emotions; (2) connectivity of visual recognition circuits in
studies that compared treatment resistant and treatment
sensitive patients; (3) response to TMS was consistently
predicted by subcallosal cortex connectivity; and (4)
hyperconnectivity of the default mode network and
hypoconnectivity of the cognitive control network
differentiated treatment-resistant from treatment-sensitive
MDD patients. LIMITATIONS: There was also considerable
variability between studies with respect to study designs
and analytic strategies that made direct comparisons across
all studies difficult. CONCLUSIONS: Continued
standardization of study designs and analytic strategies as
well as aggregation of larger datasets will allow the field
to better elucidate the potential mechanisms of action of
treatment response in patients with MDD to ultimately
generate algorithms to predict which patients will respond
to which antidepressant treatments.},
Doi = {10.1016/j.jad.2014.09.028},
Key = {fds276262}
}
@article{fds276267,
Author = {Smoski, MJ and LaBar, KS and Steffens, DC},
Title = {Relative effectiveness of reappraisal and distraction in
regulating emotion in late-life depression.},
Journal = {Am J Geriatr Psychiatry},
Volume = {22},
Number = {9},
Pages = {898-907},
Year = {2014},
Month = {September},
url = {http://www.ncbi.nlm.nih.gov/pubmed/24021222},
Abstract = {OBJECTIVES: The present study compares the effectiveness of
two strategies, reappraisal and distraction, in reducing
negative affect in older adults induced by focusing on
personally relevant negative events and stressors.
PARTICIPANTS: 30 adults with major depressive disorger (MDD)
and 40 never-depressed (ND) comparison participants ages 60
years and over (mean age = 69.7 years). DESIGN AND
MEASUREMENTS: Participants underwent three affect induction
trials, each followed by a different emotion regulation
strategy: distraction, reappraisal, and a no-instruction
control condition. Self-reported affect was recorded pre-
and post-affect induction, and at one-minute intervals
during regulation. RESULTS: Across groups, participants
reported greater reductions in negative affect with
distraction than reappraisal or the no-instruction control
condition. An interaction between group and regulation
condition indicated that distraction was more effective in
reducing negative affect in the MDD group than the ND group.
CONCLUSIONS: These results suggest that distraction is an
especially effective strategy for reducing negative affect
in older adults with MDD. Finding ways to incorporate
distraction skills into psychotherapeutic interventions for
late-life MDD may improve their effectiveness, especially
for short-term improvement of affect following
rumination.},
Doi = {10.1016/j.jagp.2013.01.070},
Key = {fds276267}
}
@article{fds276266,
Author = {Keng, S-L and Robins, CJ and Smoski, MJ and Dagenbach, J and Leary,
MR},
Title = {Reappraisal and mindfulness: a comparison of subjective
effects and cognitive costs.},
Journal = {Behav Res Ther},
Volume = {51},
Number = {12},
Pages = {899-904},
Year = {2013},
Month = {December},
url = {http://www.ncbi.nlm.nih.gov/pubmed/24225174},
Abstract = {The present study investigated the relative effects of
mindfulness and reappraisal in reducing sad mood and whether
trait mindfulness and habitual reappraisal moderated the
effects. The study also compared the extent to which
implementation of these strategies incurred cognitive
resources. A total of 129 participants were randomly
assigned to receiving training in mindfulness, reappraisal,
or no training prior to undergoing an autobiographical sad
mood induction. Results showed that mindfulness and
reappraisal were superior to no training, and equivalent in
their effects in lowering sad mood. Compared to mindfulness,
reappraisal resulted in significantly higher interference
scores on a subsequent Stroop test, reflecting greater
depletion of cognitive resources. Higher trait mindfulness,
but not habitual reappraisal, predicted greater reductions
in sadness across conditions. The study suggests that
although mindfulness and reappraisal are equally effective
in down-regulating sad mood, they incur different levels of
cognitive costs.},
Doi = {10.1016/j.brat.2013.10.006},
Key = {fds276266}
}
@article{fds276268,
Author = {Steffens, DC and McQuoid, DR and Smoski, MJ and Potter,
GG},
Title = {Clinical outcomes of older depressed patients with and
without comorbid neuroticism.},
Journal = {Int Psychogeriatr},
Volume = {25},
Number = {12},
Pages = {1985-1990},
Year = {2013},
Month = {December},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23941723},
Abstract = {BACKGROUND: Neuroticism is a psychological construct that
includes tendency to exhibit negative affect (NA), having
poor stress tolerance and being at risk for depression and
anxiety disorders. The consequences of neuroticism in the
elderly adults are understudied. We hypothesized that older
depressed patients with comorbid neuroticism at baseline
would have worse mood and cognitive outcomes compared with
older depressed patients without neuroticism. METHODS: One
hundred and ten older depressed adults completed baseline
self-reports of depression and the NEO-Personality Inventory
as a measure of neuroticism, were administered a battery of
cognitive tests annually and were seen by a study
psychiatrist who assessed patients using the Montgomery
Åsberg Depression Rating Scale (MADRS) and treated patients
with antidepressants using an established treatment
guideline. Patients were followed as clinically indicated
for up to three years. We measured remission (defined as
MADRS score ≤ 6) rates at one year as a categorical
outcome. In addition, we used Cox proportional hazard models
to examine the relationship between neuroticism and change
in MADRS and cognitive score over time. RESULTS:
Non-remitters (30%) at one year had higher scores in total
neuroticism (TN), vulnerability to stress (VS), and NA. Over
three years, time to achieve remission was associated with
higher TN, higher VS, and greater NA. In analyses
controlling for baseline cognitive score, age, sex, and
education, VS was associated with baseline to two-year
change in cognition. CONCLUSIONS: Presence of neuroticism in
older depressed patients treated with medication is
associated with poor mood outcomes and may indicate
increased risk of cognitive decline.},
Doi = {10.1017/S1041610213001324},
Key = {fds276268}
}
@article{fds276269,
Author = {Schiller, CE and Minkel, J and Smoski, MJ and Dichter,
GS},
Title = {Remitted major depression is characterized by reduced
prefrontal cortex reactivity to reward loss.},
Journal = {J Affect Disord},
Volume = {151},
Number = {2},
Pages = {756-762},
Year = {2013},
Month = {November},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23835103},
Abstract = {BACKGROUND: Major depression (MDD) is characterized by
anhedonia. Although a growing body of literature has linked
anhedonia in MDD to reduced frontostriatal activity during
reward gains, relatively few studies have examined neural
responsivity to loss, and no studies to date have examined
neural responses to loss in euthymic individuals with a
history of MDD. METHODS: An fMRI monetary incentive delay
task was administered to 19 participants with remitted MDD
(rMDD) and 19 never depressed controls. Analyses examined
group activation differences in brain reward circuitry
during monetary loss anticipation and outcomes. Secondary
analyses examined the association between self-reported
rumination and brain activation in the rMDD group. RESULTS:
Compared to controls, the rMDD group showed less superior
frontal gyrus activation during loss anticipation and less
inferior and superior frontal gyri activation during loss
outcomes (cluster corrected p's<.05). Ruminative Responses
Scale scores were negatively correlated with superior
frontal gyrus activation (r=-.68, p=.001) during loss
outcomes in the rMDD group. LIMITATIONS: Replication with a
larger sample is needed. CONCLUSIONS: Euthymic individuals
with a history of MDD showed prefrontal cortex
hypoactivation during loss anticipation and outcomes, and
the degree of superior frontal gyrus hypoactivation was
associated with rumination. Abnormal prefrontal cortex
responses to loss may reflect a trait-like vulnerability to
MDD, although future research is needed to evaluate the
utility of this functional neural endophenotype as a
prospective risk marker.},
Doi = {10.1016/j.jad.2013.06.016},
Key = {fds276269}
}
@article{fds276270,
Author = {Smoski, MJ and Keng, S-L and Schiller, CE and Minkel, J and Dichter,
GS},
Title = {Neural mechanisms of cognitive reappraisal in remitted major
depressive disorder.},
Journal = {J Affect Disord},
Volume = {151},
Number = {1},
Pages = {171-177},
Year = {2013},
Month = {October},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23796796},
Abstract = {BACKGROUND: Down-regulation of negative emotions by
cognitive strategies relies on prefrontal cortical
modulation of limbic brain regions, and impaired
frontolimbic functioning during cognitive reappraisal has
been observed in affective disorders. However, no study to
date has examined cognitive reappraisal in unmedicated
euthymic individuals with a history of major depressive
disorder relative to symptom-matched controls. Given that a
history of depression is a critical risk factor for future
depressive episodes, investigating the neural mechanisms of
emotion regulation in remitted major depressive disorder
(rMDD) may yield novel insights into depression risk.
METHOD: We assessed 37 individuals (18 rMDD, 19 controls)
with functional magnetic resonance imaging (fMRI) during a
task requiring cognitive reappraisal of sad images. RESULTS:
Both groups demonstrated decreased self-reported negative
affect after cognitive reappraisal and no group differences
in the effects of cognitive reappraisal on mood were
evident. Functional MRI results indicated greater
paracingulate gyrus (rostral anterior cingulate cortex,
Brodmann area 32) activation and decreased right midfrontal
gyrus (Brodmann area 6) activation during the reappraisal of
sad images. LIMITATIONS: Trial-by-trial ratings of
pre-regulation affect were not collected, limiting the
interpretation of post-regulation negative affect scores.
CONCLUSIONS: Results suggest that activation of rostral
anterior cingulate cortex, a region linked to the prediction
of antidepressant treatment response, and of the right
midfrontal gyrus, a region involved in cognitive control in
the context of cognitive reappraisal, may represent
endophenotypic markers of future depression risk. Future
prospective studies will be needed to validate the
predictive utility of these neural markers.},
Doi = {10.1016/j.jad.2013.05.073},
Key = {fds276270}
}
@article{fds276276,
Author = {Hayward, RD and Taylor, WD and Smoski, MJ and Steffens, DC and Payne,
ME},
Title = {Association of five-factor model personality domains and
facets with presence, onset, and treatment outcomes of major
depression in older adults.},
Journal = {Am J Geriatr Psychiatry},
Volume = {21},
Number = {1},
Pages = {88-96},
Year = {2013},
Month = {January},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23290206},
Abstract = {OBJECTIVES: To assess the relationship of multiple domains
and facets of the five-factor model of personality with
presence, onset, and severity of late-life depression.
DESIGN: Cross-sectional analysis of depression status, and
age of onset. Retrospective analysis of baseline severity.
Longitudinal analysis of severity after 3 and 12 months of
psychiatric treatment. SETTING: Private university-affiliated
medical center in the Southeastern United States.
PARTICIPANTS: One hundred twelve psychiatric patients with a
current episode of unipolar major depression, and 104
nondepressed comparison subjects, age 60 and older (mean:
70, SD: 6). MEASUREMENTS: Revised NEO Personality Inventory,
Diagnostic Interview Schedule, and Montgomery-Åsberg
Depression Rating Scale. RESULTS: Binary logistic regression
found that depression was related to higher neuroticism (and
all its facets) and to lower extraversion (and facets of
assertiveness, activity, and positive emotionality) and
conscientiousness (and facets of competence, order,
dutifulness, and self-discipline). Multinomial logistic
regression found some of these relationships held only for
depression with onset before age 50 (hostility,
self-consciousness, extraversion, assertiveness, positive
emotions, order, and dutifulness). Linear regression found
that personality was unrelated to depression severity at the
beginning of treatment, but improvement after 3 months was
related to lower neuroticism (and facets depressiveness and
stress-vulnerability) and higher warmth and competence.
Improvement after 12 months was related to lower
neuroticism, depressiveness, and stress-vulnerability.
CONCLUSIONS: Specific personality facets are related with
depression and treatment outcomes. Screening for certain
personality traits at the start of treatment may help
identify patients at risk of worse response to treatment
after 3 months.},
Doi = {10.1016/j.jagp.2012.11.012},
Key = {fds276276}
}
@article{fds276297,
Author = {Paul, NA and Stanton, SJ and Greeson, JM and Smoski, MJ and Wang,
L},
Title = {Psychological and neural mechanisms of trait mindfulness in
reducing depression vulnerability.},
Journal = {Soc Cogn Affect Neurosci},
Volume = {8},
Number = {1},
Pages = {56-64},
Year = {2013},
Month = {January},
ISSN = {1749-5024},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22717383},
Abstract = {Mindfulness-based interventions are effective for reducing
depressive symptoms. However, the psychological and neural
mechanisms are unclear. This study examined which facets of
trait mindfulness offer protection against negative bias and
rumination, which are key risk factors for depression.
Nineteen male volunteers completed a 2-day functional
magnetic resonance imaging study. One day utilized a
stress-induction task and the other day utilized a mindful
breathing task. An emotional inhibition task was used to
measure neural and behavioral changes related to state
negative bias, defined by poorer performance in inhibiting
negative relative to neutral stimuli. Associations among
trait mindfulness [measured by the Five Facet Mindfulness
Questionnaire (FFMQ)], trait rumination, and negative bias
were examined. Non-reactivity scores on the FFMQ correlated
negatively with rumination and negative bias following the
stress induction. Non-reactivity was inversely correlated
with insula activation during inhibition to negative stimuli
after the mindful breathing task. Our results suggest
non-reactivity to inner experience is the key facet of
mindfulness that protects individuals from psychological
risk for depression. Based on these results, mindfulness
could reduce vulnerability to depression in at least two
ways: (i) by buffering against trait rumination and negative
bias and (ii) by reducing automatic emotional responding via
the insula.},
Language = {eng},
Doi = {10.1093/scan/nss070},
Key = {fds276297}
}
@article{fds276271,
Author = {Wang, L and Paul, N and Stanton, SJ and Greeson, JM and Smoski,
MJ},
Title = {Loss of sustained activity in the ventromedial prefrontal
cortex in response to repeated stress in individuals with
early-life emotional abuse: implications for depression
vulnerability.},
Journal = {Front Psychol},
Volume = {4},
Pages = {320},
Year = {2013},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23761775},
Abstract = {Repeated psychosocial stress in early-life has significant
impact on both behavior and neural function which, together,
increase vulnerability to depression. However, neural
mechanisms related to repeated stress remain unclear. We
hypothesize that early-life stress may result in a reduced
capacity for cognitive control in response to a repeated
stressor, particularly in individuals who developed
maladaptive emotional processing strategies, namely trait
rumination. Individuals who encountered early-life stress
but have adaptive emotional processing, namely trait
mindfulness, may demonstrate an opposite pattern. Using a
mental arithmetic task to induce mild stress and a mindful
breathing task to induce a mindful state, we tested this
hypothesis by examining blood perfusion changes over time in
healthy young men. We found that subjects with early-life
stress, particularly emotional abuse, failed to sustain
neural activation in the orbitofrontal and ventromedial
prefrontal cortex (vmPFC) over time. Given that the vmPFC is
known to regulate amygdala activity during emotional
processing, we subsequently compared the perfusion in the
vmPFC and the amygdala in depression-vulnerable (having
early-life stress and high in rumination) and resilient
(having early-life stress and high in mindfulness) subjects.
We found that depression-vulnerable subjects had increased
amygdala perfusion and reduced vmPFC perfusion during the
later runs than that during the earlier stressful task runs.
In contrast, depression-resilient individuals showed the
reverse pattern. Our results indicate that the vmPFC of
depression-vulnerable subjects may have a limited capacity
to inhibit amygdala activation to repeated stress over time,
whereas the vmPFC in resilient individuals may adapt to
stress quickly. This pilot study warrants future
investigation to clarify the stress-related neural activity
pattern dynamically to identify depression vulnerability at
an individual level.},
Doi = {10.3389/fpsyg.2013.00320},
Key = {fds276271}
}
@article{fds276286,
Author = {Felder, JN and Smoski, MJ and Kozink, RV and Froeliger, B and McClernon,
J and Bizzell, J and Petty, C and Dichter, GS},
Title = {Neural mechanisms of subclinical depressive symptoms in
women: a pilot functional brain imaging study.},
Journal = {BMC Psychiatry},
Volume = {12},
Pages = {152},
Year = {2012},
Month = {September},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22998631},
Abstract = {BACKGROUND: Studies of individuals who do not meet criteria
for major depressive disorder (MDD) but with subclinical
levels of depressive symptoms may aid in the identification
of neurofunctional abnormalities that possibly precede and
predict the development of MDD. The purpose of this study
was to evaluate relations between subclinical levels of
depressive symptoms and neural activation patterns during
tasks previously shown to differentiate individuals with and
without MDD. METHODS: Functional magnetic resonance imaging
(fMRI) was used to assess neural activations during active
emotion regulation, a resting state scan, and reward
processing. Participants were twelve females with a range of
depressive symptoms who did not meet criteria for MDD.
RESULTS: Increased depressive symptom severity predicted (1)
decreased left midfrontal gyrus activation during
reappraisal of sad stimuli; (2) increased right midfrontal
gyrus activation during distraction from sad stimuli; (3)
increased functional connectivity between a precuneus seed
region and left orbitofrontal cortex during a resting state
scan; and (4) increased paracingulate activation during
non-win outcomes during a reward-processing task.
CONCLUSIONS: These pilot data shed light on relations
between subclinical levels of depressive symptoms in the
absence of a formal MDD diagnosis and neural activation
patterns. Future studies will be needed to test the utility
of these activation patterns for predicting MDD onset in
at-risk samples.},
Doi = {10.1186/1471-244X-12-152},
Key = {fds276286}
}
@article{fds276281,
Author = {Itzhar-Nabarro, Z and Smoski, MJ},
Title = {A Review of Theoretical and Empirical Perspectives on
Marital Satisfaction and Bereavement Outcomes: Implications
for Working with Older Adults},
Journal = {Clinical Gerontologist},
Volume = {35},
Number = {3},
Pages = {257-269},
Publisher = {Informa UK Limited},
Year = {2012},
Month = {May},
ISSN = {0731-7115},
Abstract = {The later years of one's life can contain many losses,
perhaps none as prominent as the loss of one's spouse.
Bereavement can be a life-changing loss, but the nature of
that change can range from despair and depression to
personal growth and resiliency. One factor that can play a
role in bereavement outcomes is the quality of the lost
relationship. It does not appear that the relationship
between marital satisfaction and bereavement outcomes is as
clear-cut as poor relationships leading to poor outcomes or
vice-versa, however. Rather, multiple factors related to
relationship dynamics, attachment style, and dependency may
influence bereavement trajectories. In addition, marital
satisfaction may interact with other factors including
pre-loss psychological health and personality
characteristics to influence outcomes. Similar factors may
also influence the bereaved individual's post-loss
assessment of the relationship, leading to idealization of
the lost spouse and making clini vement and/or the need for
intervention. © 2012 Taylor and Francis Group,
LLC.},
Doi = {10.1080/07317115.2012.657604},
Key = {fds276281}
}
@article{fds276290,
Author = {Hayward, RD and Taylor, WD and Smoski, MJ and Steffens, DC and Payne,
ME},
Title = {Association of Five-Factor Model Personality Domains and
Facets with Presence, Onset, and Treatment Outcomes of Major
Depression in Older Adults.},
Journal = {Am J Geriatr Psychiatry},
Year = {2012},
Month = {March},
ISSN = {1545-7214},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22426521},
Abstract = {OBJECTIVES:: To assess the relationship of multiple domains
and facets of the five-factor model of personality with
presence, onset, and severity of late-life depression.
DESIGN:: Cross-sectional analysis of depression status, and
age of onset. Retrospective analysis of baseline severity.
Longitudinal analysis of severity after 3 and 12 months of
psychiatric treatment. SETTING:: Private
university-affiliated medical center in the Southeastern
United States. PARTICIPANTS:: One hundred twelve psychiatric
patients with a current episode of unipolar major
depression, and 104 nondepressed comparison subjects, age 60
and older (mean: 70, SD: 6). MEASUREMENTS:: Revised NEO
Personality Inventory, Diagnostic Interview Schedule, and
Montgomery-Åsberg Depression Rating Scale. RESULTS:: Binary
logistic regression found that depression was related to
higher neuroticism (and all its facets) and to lower
extraversion (and facets of assertiveness, activity, and
positive emotionality) and conscientiousness (and facets of
competence, order, dutifulness, and self-discipline).
Multinomial logistic regression found some of these
relationships held only for depression with onset before age
50 (hostility, self-consciousness, extraversion,
assertiveness, positive emotions, order, and dutifulness).
Linear regression found that personality was unrelated to
depression severity at the beginning of treatment, but
improvement after 3 months was related to lower neuroticism
(and facets depressiveness and stress-vulnerability) and
higher warmth and competence. Improvement after 12 months
was related to lower neuroticism, depressiveness, and
stress-vulnerability. CONCLUSIONS:: Specific personality
facets are related with depression and treatment outcomes.
Screening for certain personality traits at the start of
treatment may help identify patients at risk of worse
response to treatment after 3 months.},
Language = {ENG},
Doi = {10.1097/JGP.0b013e3182436200},
Key = {fds276290}
}
@article{fds276288,
Author = {Dichter, GS and Kozink, RV and McClernon, FJ and Smoski,
MJ},
Title = {Remitted major depression is characterized by reward network
hyperactivation during reward anticipation and
hypoactivation during reward outcomes.},
Journal = {J Affect Disord},
Volume = {136},
Number = {3},
Pages = {1126-1134},
Year = {2012},
Month = {February},
ISSN = {1573-2517},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22036801},
Keywords = {Adult • Anticipation, Psychological • Brain •
Depressive Disorder, Major • Female • Humans
• Magnetic Resonance Imaging • Male •
Motivation • Prospective Studies • Reward* •
Young Adult • diagnosis* • physiopathology*},
Abstract = {BACKGROUND: Although functional brain imaging has
established that individuals with unipolar major depressive
disorder (MDD) are characterized by frontostriatal
dysfunction during reward processing, no research to date
has examined the chronometry of neural responses to rewards
in euthymic individuals with a history of MDD. METHOD: A
monetary incentive delay task was used during fMRI scanning
to assess neural responses in frontostriatal reward regions
during reward anticipation and outcomes in 19 participants
with remitted major depressive disorder (rMDD) and in 19
matched control participants. RESULTS: During the
anticipation phase of the task, the rMDD group was
characterized by relatively greater activation in bilateral
anterior cingulate gyrus, in right midfrontal gyrus, and in
the right cerebellum. During the outcome phase of the task,
the rMDD group was characterized by relatively decreased
activation in bilateral orbital frontal cortex, right
frontal pole, left insular cortex, and left thalamus.
Exploratory analyses indicated that activation within a
right frontal pole cluster that differentiated groups during
reward anticipation predicted the number of lifetime
depressive episodes within the rMDD group. LIMITATIONS:
Replication with larger samples is needed. CONCLUSIONS:
Results suggest a double dissociation between reward network
reactivity and temporal phase of the reward response in
rMDD, such that rMDD is generally characterized by reward
network hyperactivation during reward anticipation and
reward network hypoactivation during reward outcomes. More
broadly, these data suggest that aberrant frontostriatal
response to rewards may potentially represent a trait marker
for MDD, though future research is needed to evaluate the
prospective utility of this functional neural endophenotype
as a marker of MDD risk.},
Language = {eng},
Doi = {10.1016/j.jad.2011.09.048},
Key = {fds276288}
}
@article{fds276284,
Author = {Keng, SL and Smoski, MJ and Robins, CJ and Ekblad, AG and Brantley,
JG},
Title = {Mechanisms of change in mindfulness-based stress reduction:
Self-compassion and mindfulness as mediators of intervention
outcomes},
Journal = {Journal of Cognitive Psychotherapy},
Volume = {26},
Number = {3},
Pages = {270-280},
Publisher = {Springer Publishing Company},
Year = {2012},
Month = {January},
ISSN = {0889-8391},
Abstract = {Research has demonstrated support for the efficacy of
mindfulness-based stress reduction (MBSR) in alleviating
psychological distress and symptoms. Less is known, however,
about the mechanisms through which MBSR achieves its
outcomes. This study examined mindfulness and
self-compassion as potential mediators of MBSR's effects on
several processes and behaviors related to emotion
regulation, using data from a randomized trial of MBSR
versus waitlist (WL), in which MBSR participants
demonstrated significantly greater improvements in worry,
fear of emotion, difficulties in emotion regulation,
suppression of anger, and aggressive anger expression.
Mediation analysis using bootstrap resampling indicated that
increases in self-compassion mediated MBSR's effects on
worry, controlling for change in mindfulness. Increases in
mindfulness mediated the intervention's effects on
difficulties in emotion regulation, controlling for change
in self-compassion. Both variables mediated MBSR's effects
on fear of emotion. These findings highlight the importance
of mindfulness and self-compassion as key processes of
change that underlie MBSR's outcomes. © 2012 Springer
Publishing Company.},
Doi = {10.1891/0889-8391.26.3.270},
Key = {fds276284}
}
@article{fds276285,
Author = {Addicott, MA and Baranger, DAA and Kozink, RV and Smoski, MJ and Dichter, GS and McClernon, FJ},
Title = {Erratum: Smoking withdrawal is associated with increases in
brain activation during decision making and reward
anticipation: A preliminary study},
Journal = {Psychopharmacology},
Volume = {219},
Number = {2},
Pages = {685-686},
Publisher = {Springer Nature},
Year = {2012},
Month = {January},
ISSN = {0033-3158},
Doi = {10.1007/s00213-011-2531-x},
Key = {fds276285}
}
@article{fds276293,
Author = {Addicott, MA and Baranger, DAA and Kozink, RV and Smoski, MJ and Dichter, GS and McClernon, FJ},
Title = {Smoking withdrawal is associated with increases in brain
activation during decision making and reward anticipation: a
preliminary study.},
Journal = {Psychopharmacology (Berl)},
Volume = {219},
Number = {2},
Pages = {563-573},
Year = {2012},
Month = {January},
ISSN = {1432-2072},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21766170},
Keywords = {Adolescent • Adult • Anticipation, Psychological
• Brain • Brain Mapping • Choice Behavior
• Decision Making • Female • Humans •
Magnetic Resonance Imaging • Male • Middle Aged
• Psychomotor Performance • Reaction Time •
Reward* • Substance Withdrawal Syndrome • Tobacco
Use Disorder • methods • physiology •
physiology* • physiopathology* •
psychology*},
Abstract = {RATIONALE: Acute nicotine abstinence is associated with
disruption of executive function and reward processes;
however, the neurobiological basis of these effects has not
been fully elucidated. METHODS: The effects of nicotine
abstinence on brain function during reward-based
probabilistic decision making were preliminarily
investigated by scanning adult smokers (n = 13)
following 24 h of smoking abstinence and in a
smoking-satiated condition. During fMRI scanning,
participants completed the wheel of fortune task (Ernst et
al. in Neuropsychologia 42:1585-1597, 2004), a
decision-making task with probabilistic monetary outcomes.
Brain activation was modeled during selection of options,
anticipation of outcomes, and outcome feedback. RESULTS:
During choice selection, reaction times were slower, and
there was greater neural activation in the postcentral
gyrus, insula, and frontal and parietal cortices in the
abstinent condition compared to the satiated condition.
During reward anticipation, greater activation was observed
in the frontal pole, insula, and paracingulate cortex in the
abstinent condition compared to the satiated condition.
Greater activation was also shown in the precentral gyrus
and putamen in the satiated condition compared to the
abstinent condition. During the outcome phase, rewards
(compared to no rewards) resulted in significant activation
in the paracingulate cortex in the satiated condition
compared to the abstinent condition. CONCLUSIONS: The
results of this preliminary study suggest that smoking
withdrawal results in greater recruitment of insular,
frontal, and parietal cortical areas during probabilistic
decision making.},
Language = {eng},
Doi = {10.1007/s00213-011-2404-3},
Key = {fds276293}
}
@article{fds276294,
Author = {Smoski, MJ and Rittenberg, A and Dichter, GS},
Title = {Major depressive disorder is characterized by greater reward
network activation to monetary than pleasant image
rewards.},
Journal = {Psychiatry Res},
Volume = {194},
Number = {3},
Pages = {263-270},
Year = {2011},
Month = {December},
ISSN = {0165-1781},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22079658},
Keywords = {Adolescent • Adult • Brain • Brain Mapping
• Choice Behavior • Depressive Disorder, Major*
• Emotions* • Female • Games, Experimental
• Humans • Image Processing, Computer-Assisted
• Magnetic Resonance Imaging • Male • Middle
Aged • Motivation • Multivariate Analysis •
Nerve Net • Oxygen • Reaction Time • Reward*
• Young Adult • blood • blood supply •
diagnosis • pathology* • physiology •
physiology* • physiopathology •
psychology},
Abstract = {Anhedonia, the loss of interest or pleasure in normally
rewarding activities, is a hallmark feature of unipolar
Major Depressive Disorder (MDD). A growing body of
literature has identified frontostriatal dysfunction during
reward anticipation and outcomes in MDD. However, no study
to date has directly compared responses to different types
of rewards such as pleasant images and monetary rewards in
MDD. To investigate the neural responses to monetary and
pleasant image rewards in MDD, a modified Monetary Incentive
Delay task was used during functional magnetic resonance
imaging to assess neural responses during anticipation and
receipt of monetary and pleasant image rewards. Participants
included nine adults with MDD and 13 affectively healthy
controls. The MDD group showed lower activation than
controls when anticipating monetary rewards in right
orbitofrontal cortex and subcallosal cortex, and when
anticipating pleasant image rewards in paracingulate and
supplementary motor cortex. The MDD group had relatively
greater activation in right putamen when anticipating
monetary versus pleasant image rewards, relative to the
control group. Results suggest reduced reward network
activation in MDD when anticipating rewards, as well as
relatively greater hypoactivation to pleasant image than
monetary rewards.},
Language = {eng},
Doi = {10.1016/j.pscychresns.2011.06.012},
Key = {fds276294}
}
@article{fds276295,
Author = {Greeson, JM and Webber, DM and Smoski, MJ and Brantley, JG and Ekblad,
AG and Suarez, EC and Wolever, RQ},
Title = {Changes in spirituality partly explain health-related
quality of life outcomes after Mindfulness-Based Stress
Reduction.},
Journal = {J Behav Med},
Volume = {34},
Number = {6},
Pages = {508-518},
Year = {2011},
Month = {December},
ISSN = {1573-3521},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21360283},
Keywords = {Adult • Aged • Female • Health Surveys •
Humans • Male • Meditation • Middle Aged
• Models, Psychological • Quality of Life •
Spirituality* • Stress, Psychological • methods
• psychology* • statistics & numerical data •
therapy*},
Abstract = {Mindfulness-Based Stress Reduction is a secular behavioral
medicine program that has roots in meditative spiritual
practices. Thus, spirituality may partly explain
Mindfulness-Based Stress Reduction outcomes. Participants
(N = 279; M (SD) age = 45(12); 75% women) completed an
online survey before and after an 8-week Mindfulness-Based
Stress Reduction program. Structural equation modeling was
used to test the hypothesis that, following
Mindfulness-Based Stress Reduction, the relationship between
enhanced mindfulness and improved health-related quality of
life is mediated by increased daily spiritual experiences.
Changes in both spirituality and mindfulness were
significantly related to improvement in mental health.
Although the initial mediation hypothesis was not supported,
an alternate model suggested that enhanced mindfulness
partly mediated the association between increased daily
spiritual experiences and improved mental health-related
quality of life (indirect effect: β = 0.07, P = 0.017).
Effects on physical health-related quality of life were not
significant. Findings suggest a novel mechanism by which
increased daily spiritual experiences following
Mindfulness-Based Stress Reduction may partially explain
improved mental health as a function of greater
mindfulness.},
Language = {eng},
Doi = {10.1007/s10865-011-9332-x},
Key = {fds276295}
}
@article{fds276292,
Author = {Rosenthal, MZ and Kim, K and Herr, NR and Smoski, MJ and Cheavens, JS and Lynch, TR and Kosson, DS},
Title = {Speed and accuracy of facial expression classification in
avoidant personality disorder: a preliminary
study.},
Journal = {Personal Disord},
Volume = {2},
Number = {4},
Pages = {327-334},
Year = {2011},
Month = {October},
ISSN = {1949-2723},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22448805},
Abstract = {The aim of this preliminary study was to examine whether
individuals with avoidant personality disorder (APD) could
be characterized by deficits in the classification of
dynamically presented facial emotional expressions. Using a
community sample of adults with APD (n = 17) and non-APD
controls (n = 16), speed and accuracy of facial emotional
expression recognition was investigated in a task that
morphs facial expressions from neutral to prototypical
expressions (Multi-Morph Facial Affect Recognition Task;
Blair, Colledge, Murray, & Mitchell, 2001). Results
indicated that individuals with APD were significantly more
likely than controls to make errors when classifying fully
expressed fear. However, no differences were found between
groups in the speed to correctly classify facial emotional
expressions. The findings are some of the first to
investigate facial emotional processing in a sample of
individuals with APD and point to an underlying deficit in
processing social cues that may be involved in the
maintenance of APD.},
Language = {eng},
Doi = {10.1037/a0023672},
Key = {fds276292}
}
@article{fds276298,
Author = {Keng, S-L and Smoski, MJ and Robins, CJ},
Title = {Effects of mindfulness on psychological health: a review of
empirical studies.},
Journal = {Clin Psychol Rev},
Volume = {31},
Number = {6},
Pages = {1041-1056},
Year = {2011},
Month = {August},
ISSN = {1873-7811},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21802619},
Keywords = {Awareness • Cognitive Therapy • Humans •
Meditation • Mental Health* • Mind-Body Relations,
Metaphysical* • Stress, Psychological • methods
• psychology • therapy*},
Abstract = {Within the past few decades, there has been a surge of
interest in the investigation of mindfulness as a
psychological construct and as a form of clinical
intervention. This article reviews the empirical literature
on the effects of mindfulness on psychological health. We
begin with a discussion of the construct of mindfulness,
differences between Buddhist and Western psychological
conceptualizations of mindfulness, and how mindfulness has
been integrated into Western medicine and psychology, before
reviewing three areas of empirical research:
cross-sectional, correlational research on the associations
between mindfulness and various indicators of psychological
health; intervention research on the effects of
mindfulness-oriented interventions on psychological health;
and laboratory-based, experimental research on the immediate
effects of mindfulness inductions on emotional and
behavioral functioning. We conclude that mindfulness brings
about various positive psychological effects, including
increased subjective well-being, reduced psychological
symptoms and emotional reactivity, and improved behavioral
regulation. The review ends with a discussion on mechanisms
of change of mindfulness interventions and suggested
directions for future research.},
Language = {eng},
Doi = {10.1016/j.cpr.2011.04.006},
Key = {fds276298}
}
@article{fds276289,
Author = {Smoski, MJ and Salsman, N and Wang, L and Smith, V and Lynch, TR and Dager,
SR and LaBar, KS and Linehan, MM},
Title = {Functional imaging of emotion reactivity in opiate-dependent
borderline personality disorder.},
Journal = {Personal Disord},
Volume = {2},
Number = {3},
Pages = {230-241},
Year = {2011},
Month = {July},
ISSN = {1949-2723},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22448769},
Keywords = {Adult • Analysis of Variance • Arousal •
Borderline Personality Disorder • Brain Mapping •
Buprenorphine • Case-Control Studies • Comorbidity
• Cues • Drug Combinations • Emotions •
Functional Laterality • Humans • Limbic System
• Magnetic Resonance Imaging • Male •
Naloxone • Narcotic Antagonists • Opiate
Substitution Treatment • Opioid-Related Disorders
• Reaction Time • Self Report • drug therapy
• epidemiology • methods • pathology* •
physiology • physiology* • physiopathology •
psychology • therapeutic use},
Abstract = {Opiate dependence (OD) and borderline personality disorder
(BPD), separately and together, are significant public
health problems with poor treatment outcomes. BPD is
associated with difficulties in emotion regulation, and
brain-imaging studies in BPD individuals indicate
differential activation in prefrontal cingulate cortices and
their interactions with limbic regions. Likewise, a similar
network is implicated in drug cue responsivity in substance
abusers. The present, preliminary study used functional MRI
to examine activation of this network in comorbid OD/BPD
participants when engaged in an "oddball" task that required
attention to a target in the context of emotionally negative
distractors. Twelve male OD/BPD participants and 12 male
healthy controls participated. All OD/BPD participants were
taking the opiate replacement medication Suboxone, and a
subset of participants was positive for substances of abuse
on scan day. Relative to controls, OD/BPD participants
demonstrated reduced activation to negative stimuli in the
amygdala and anterior cingulate. Unlike previous studies
that demonstrated hyperresponsivity in neural regions
associated with affective processing in individuals with BPD
versus healthy controls, comorbid OD/BPD participants were
hyporesponsive to emotional cues. Future studies that also
include BPD-only and OD-only groups are necessary to help
clarify the individual and potentially synergistic effects
of these two conditions.},
Language = {eng},
Doi = {10.1037/a0022228},
Key = {fds276289}
}
@article{fds276287,
Author = {Dichter, GS and Felder, JN and Smoski, MJ},
Title = {The effects of Brief Behavioral Activation Therapy for
Depression on cognitive control in affective contexts: An
fMRI investigation.},
Journal = {J Affect Disord},
Volume = {126},
Number = {1-2},
Pages = {236-244},
Year = {2010},
Month = {October},
ISSN = {1573-2517},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20421135},
Keywords = {Adult • Affect • Brain • Case-Control Studies
• Cognition • Cognitive Therapy* • Depressive
Disorder, Major • Female • Humans • Magnetic
Resonance Imaging • Male • Psychiatric Status
Rating Scales • physiology • physiology* •
physiopathology • physiopathology* • psychology
• therapy},
Abstract = {BACKGROUND: Unipolar major depressive disorder (MDD) is
characterized by impaired cognitive control in affective
contexts, but the potential for psychotherapy to affect the
neural correlates of these functions has not been evaluated.
METHOD: Twelve adults with and 15 adults without MDD
participated in two identical functional magnetic resonance
imaging (fMRI) scans that utilized a task requiring
cognitive control in both sad and neutral contexts. Between
scans, MDD outpatients received Behavioral Activation
Therapy for Depression, a psychotherapy modality designed to
increase engagement with positive stimuli and reduce
avoidance behaviors. RESULTS: Seventy-five percent of adults
with MDD were treatment responders, achieving post-treatment
Hamilton Rating Scale for Depression score of six or below.
Consistent with predictions, psychotherapy resulted in
decreased activation in response to cognitive control
stimuli presented within a sad context in prefrontal
structures, including the paracingulate gyrus, the right
orbital frontal cortex, and the right frontal pole.
Furthermore, the magnitude of pretreatment activation in the
paracingulate gyrus cluster responsive to psychotherapy
predicted the magnitude of depressive symptom change after
psychotherapy. LIMITATIONS: Replication with larger samples
is needed, as are follow-up studies that involve placebo
control groups, wait-list control groups, and alternative
forms of antidepressant intervention. CONCLUSIONS:
Behavioral Activation Therapy for Depression improves
depressive symptoms and concomitantly influences brain
systems mediating cognitive control in affective
contexts.},
Language = {eng},
Doi = {10.1016/j.jad.2010.03.022},
Key = {fds276287}
}
@article{fds276296,
Author = {Dichter, GS and Smoski, MJ and Kampov-Polevoy, AB and Gallop, R and Garbutt, JC},
Title = {Unipolar depression does not moderate responses to the Sweet
Taste Test.},
Journal = {Depress Anxiety},
Volume = {27},
Number = {9},
Pages = {859-863},
Year = {2010},
Month = {September},
ISSN = {1520-6394},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20336799},
Keywords = {Adult • Bipolar Disorder • Case-Control Studies
• Depressive Disorder, Major • Female •
Humans • Male • Middle Aged • Psychotherapy
• Sucrose • Taste* • Young Adult •
administration & dosage* • diagnosis •
epidemiology • psychology* • therapy},
Abstract = {BACKGROUND: The Sweet Taste Test (STT) measures hedonic
responses to sweet tastes and has been linked to both
alcoholism and to a family history of alcoholism. However,
STT response profiles in unipolar major depressive disorder
(MDD), a disorder characterized by anhedonia, have been
minimally investigated. METHODS: Twelve adults with and 15
adults without MDD participated in two identical STT
assessments separated by approximately 12 weeks. Between
assessments, MDD outpatients received Behavioral Activation
Therapy for Depression, a psychotherapy modality designed to
increase engagement with rewarding stimuli and reduce
avoidance behaviors. Primary-dependent measures included
sensitivity to sucrose, hedonic response to sucrose, and
designation as a Sweet-Liker or Sweet-Disliker. RESULTS: A
total of 75% of adults with MDD were treatment responders.
There were no significant differences in STT response
profiles between groups overall or at either timepoint.
Furthermore, STT profiles of MDD participants did not differ
after psychotherapy, relative to baseline. CONCLUSIONS:
Findings suggest that although anhedonia is a symptom of
MDD, the disorder is not characterized by altered responses
to sweet tastes. Implications and future directions are
discussed.},
Language = {eng},
Doi = {10.1002/da.20690},
Key = {fds276296}
}
@article{fds276291,
Author = {Hayes, JP and Morey, RA and Petty, CM and Seth, S and Smoski, MJ and McCarthy, G and Labar, KS},
Title = {Staying cool when things get hot: emotion regulation
modulates neural mechanisms of memory encoding.},
Journal = {Front Hum Neurosci},
Volume = {4},
Pages = {230},
Year = {2010},
ISSN = {1662-5161},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21212840},
Abstract = {During times of emotional stress, individuals often engage
in emotion regulation to reduce the experiential and
physiological impact of negative emotions. Interestingly,
emotion regulation strategies also influence memory encoding
of the event. Cognitive reappraisal is associated with
enhanced memory while expressive suppression is associated
with impaired explicit memory of the emotional event.
However, the mechanism by which these emotion regulation
strategies affect memory is unclear. We used event-related
fMRI to investigate the neural mechanisms that give rise to
memory formation during emotion regulation. Twenty-five
participants viewed negative pictures while alternately
engaging in cognitive reappraisal, expressive suppression,
or passive viewing. As part of the subsequent memory design,
participants returned to the laboratory two weeks later for
a surprise memory test. Behavioral results showed a
reduction in negative affect and a retention advantage for
reappraised stimuli relative to the other conditions.
Imaging results showed that successful encoding during
reappraisal was uniquely associated with greater
co-activation of the left inferior frontal gyrus, amygdala,
and hippocampus, suggesting a possible role for elaborative
encoding of negative memories. This study provides
neurobehavioral evidence that engaging in cognitive
reappraisal is advantageous to both affective and mnemonic
processes.},
Language = {eng},
Doi = {10.3389/fnhum.2010.00230},
Key = {fds276291}
}
@article{fds276299,
Author = {Smoski, MJ and Felder, J and Bizzell, J and Green, SR and Ernst, M and Lynch, TR and Dichter, GS},
Title = {fMRI of alterations in reward selection, anticipation, and
feedback in major depressive disorder.},
Journal = {J Affect Disord},
Volume = {118},
Number = {1-3},
Pages = {69-78},
Year = {2009},
Month = {November},
ISSN = {1573-2517},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19261334},
Keywords = {Adult • Arousal • Brain • Brain Mapping
• Choice Behavior • Corpus Striatum •
Decision Making • Depressive Disorder, Major •
Dominance, Cerebral • Feedback, Psychological •
Female • Frontal Lobe • Gyrus Cinguli •
Humans • Image Processing, Computer-Assisted* •
Magnetic Resonance Imaging* • Male • Middle Aged
• Motivation • Nerve Net • Nucleus Accumbens
• Reward* • Young Adult • diagnosis •
physiology • physiology* • physiopathology •
physiopathology* • psychology},
Abstract = {The purpose of the present investigation was to evaluate
reward processing in unipolar major depressive disorder
(MDD). Specifically, we investigated whether adults with MDD
demonstrated hyporesponsivity in striatal brain regions
and/or hyperresponsivity in cortical brain regions involved
in conflict monitoring using a Wheel of Fortune task
designed to probe responses during reward selection, reward
anticipation, and reward feedback. Functional magnetic
resonance imaging (fMRI) data indicated that the MDD group
was characterized by reduced activation of striatal reward
regions during reward selection, reward anticipation, and
reward feedback, supporting previous data indicating
hyporesponsivity of reward systems in MDD. Support was not
found for hyperresponsivity of cognitive control regions
during reward selection or reward anticipation. Instead, MDD
participants showed hyperresponsivity in orbitofrontal
cortex, a region associated with assessment of risk and
reward, during reward selection, as well as decreased
activation of the middle frontal gyrus and the rostral
cingulate gyrus during reward selection and anticipation.
Finally, depression severity was predicted by activation in
bilateral midfrontal gyrus during reward selection. Results
indicate that MDD is characterized by striatal
hyporesponsivity, and that future studies of MDD treatments
that seek to improve responses to rewarding stimuli should
assess striatal functioning.},
Language = {eng},
Doi = {10.1016/j.jad.2009.01.034},
Key = {fds276299}
}
@article{fds276300,
Author = {Dichter, GS and Felder, JN and Petty, C and Bizzell, J and Ernst, M and Smoski, MJ},
Title = {The effects of psychotherapy on neural responses to rewards
in major depression.},
Journal = {Biol Psychiatry},
Volume = {66},
Number = {9},
Pages = {886-897},
Year = {2009},
Month = {November},
ISSN = {1873-2402},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19726030},
Keywords = {Adult • Brain • Brain Mapping • Depressive
Disorder, Major • Female • Humans • Magnetic
Resonance Imaging • Male • Middle Aged •
Psychomotor Performance • Psychotherapy* • Reward*
• physiology* • physiopathology* •
therapy},
Abstract = {BACKGROUND: Unipolar major depressive disorder (MDD) is
characterized by anomalous neurobiological responses to
pleasant stimuli, a pattern that may be linked to symptoms
of anhedonia. However, the potential for psychotherapy to
normalize neurobiological responses to pleasant stimuli has
not been evaluated. METHODS: Twelve adults with and 15
adults without MDD participated in two identical functional
magnetic resonance imaging scans that used a Wheel of
Fortune task. Between scans, MDD outpatients received
Behavioral Activation Therapy for Depression, a
psychotherapy modality designed to increase engagement with
rewarding stimuli and reduce avoidance behaviors. RESULTS:
Seventy-five percent of adults with MDD were treatment
responders, achieving post-treatment Hamilton Rating Scale
for Depression score of six or below. Relative to changes in
brain function in the matched nondepressed group,
psychotherapy resulted in functional changes in structures
that mediate responses to rewards, including the
paracingulate gyrus during reward selection, the right
caudate nucleus (i.e., the dorsal striatum), during reward
anticipation, and the paracingulate and orbital frontal gyri
during reward feedback. There was no effect of diagnostic
status or psychotherapy on in-scanner task-related
behavioral responses. CONCLUSIONS: Behavioral Activation
Therapy for Depression, a psychotherapy modality designed to
increase engagement with rewarding stimuli and reduce
avoidance behaviors, results in improved functioning of
unique reward structures during different temporal phases of
responses to pleasurable stimuli, including the dorsal
striatum during reward anticipation.},
Language = {eng},
Doi = {10.1016/j.biopsych.2009.06.021},
Key = {fds276300}
}
@article{fds276305,
Author = {Dichter, GS and Felder, JN and Smoski, MJ},
Title = {Affective context interferes with cognitive control in
unipolar depression: an fMRI investigation.},
Journal = {J Affect Disord},
Volume = {114},
Number = {1-3},
Pages = {131-142},
Year = {2009},
Month = {April},
ISSN = {1573-2517},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18706701},
Keywords = {Adult • Affect* • Brain • Case-Control
Studies • Cognition* • Depressive Disorder, Major
• Facial Expression • Female • Frontal Lobe
• Functional Laterality • Gyrus Cinguli •
Humans • Image Processing, Computer-Assisted •
Magnetic Resonance Imaging* • Male • Middle Aged
• Neuropsychological Tests • Photic Stimulation
• Prefrontal Cortex • Psychomotor Performance*
• Visual Perception* • Young Adult •
diagnosis • methods • physiopathology •
physiopathology* • psychology*},
Abstract = {BACKGROUND: Unipolar major depressive disorder (MDD) is
characterized by aberrant amygdala responses to sad stimuli
and poor cognitive control, but the interactive effects of
these impairments are poorly understood. AIM: To evaluate
brain activation in MDD in response to cognitive control
stimuli embedded within sad and neutral contexts. METHOD:
Fourteen adults with MDD and fifteen matched controls
participated in a mixed block/event-related functional
magnetic resonance imaging (fMRI) task that presented
oddball target stimuli embedded within blocks of sad or
neutral images. RESULTS: Target events activated similar
prefrontal brain regions in both groups. However, responses
to target events embedded within blocks of emotional images
revealed a clear group dissociation. During neutral blocks,
the control group demonstrated greater activation to targets
in the midfrontal gyrus and anterior cingulate relative to
the MDD group, replicating previous findings of prefrontal
hypo-activation in MDD samples to cognitive control stimuli.
However, during sad blocks, the MDD group demonstrated
greater activation in a number of prefrontal regions,
including the mid-, inferior, and orbito-frontal gyri and
the anterior cingulate, suggesting that relatively more
prefrontal brain activation was required to disengage from
the sad images to respond to the target events. LIMITATIONS:
A larger sample size would have provided greater statistical
power, and more standardized stimuli would have increased
external validity. CONCLUSIONS: This double dissociation of
prefrontal responses to target events embedded within
neutral and sad context suggests that MDD impacts not only
responses to affective events, but extends to other
cognitive processes carried out in the context of affective
engagement. This implies that emotional reactivity to sad
events in MDD may impact functioning more broadly than
previously understood.},
Language = {eng},
Doi = {10.1016/j.jad.2008.06.027},
Key = {fds276305}
}
@article{fds276301,
Author = {Smoski, MJ and Lynch, TR and Rosenthal, MZ and Cheavens, JS and Chapman,
AL and Krishnan, RR},
Title = {Decision-making and risk aversion among depressive
adults.},
Journal = {J Behav Ther Exp Psychiatry},
Volume = {39},
Number = {4},
Pages = {567-576},
Year = {2008},
Month = {December},
ISSN = {0005-7916},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18342834},
Keywords = {Adult • Choice Behavior • Control Groups •
Decision Making* • Depressive Disorder • Feedback
• Female • Gambling • Humans • Male
• Models, Psychological • Neuropsychological Tests
• Punishment • Reward • Risk-Taking* •
Task Performance and Analysis • diagnosis* •
psychology},
Abstract = {Depression is associated with behavioral avoidance of
potentially rewarding environmental contexts. The present
study examined the performance of depressive individuals and
controls on a neuropsychological measure of decision-making
that favors risk avoidance. Depressive (n=41) and control
(n=44) participants were administered the Iowa Gambling
Task, which measures the ability of participants to maximize
earnings by choosing low-risk, low-reward responses over
high-risk, high-reward responses. Results provided partial
support for the hypothesis that depressive participants
would learn to avoid risky responses faster than control
participants. Depressive participants demonstrated better
performance than controls, scoring higher than controls
overall and showing a trend toward earning more money
overall. However, the lack of an interaction between
depressive status and time does not support the specific
hypothesis of more rapid learning. Findings suggested
enhanced feedback-based decision-making and risk aversion
among depressive individuals.},
Language = {eng},
Doi = {10.1016/j.jbtep.2008.01.004},
Key = {fds276301}
}
@article{fds276280,
Author = {Dichter, GS and Felder, JN and Smoski, M},
Title = {Effects of psychotherapy on brain function: Brain imaging
studies indicate changes},
Journal = {Psychiatric Times},
Volume = {25},
Number = {10},
Pages = {34-38},
Year = {2008},
Month = {September},
ISSN = {0893-2905},
Key = {fds276280}
}
@article{fds276308,
Author = {Wang, L and LaBar, KS and Smoski, M and Rosenthal, MZ and Dolcos, F and Lynch, TR and Krishnan, RR and McCarthy, G},
Title = {Prefrontal mechanisms for executive control over emotional
distraction are altered in major depression.},
Journal = {Psychiatry Res},
Volume = {163},
Number = {2},
Pages = {143-155},
Year = {2008},
Month = {July},
ISSN = {0165-1781},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18455373},
Keywords = {Adult • Arousal • Attention • Brain Mapping
• Cerebral Cortex • Depressive Disorder, Major
• Discrimination Learning • Dominance, Cerebral
• Emotions • Facial Expression • Female
• Frontal Lobe • Gyrus Cinguli • Humans
• Image Processing, Computer-Assisted* • Magnetic
Resonance Imaging* • Male • Middle Aged •
Pattern Recognition, Visual • Prefrontal Cortex •
Psychomotor Performance • Reaction Time •
diagnosis • physiology • physiology* •
physiopathology • physiopathology* •
psychology},
Abstract = {A dysfunction in the interaction between executive function
and mood regulation has been proposed as the pathophysiology
of depression. However, few studies have investigated the
alteration in brain systems related to executive control
over emotional distraction in depression. To address this
issue, 19 patients with major depressive disorder (MDD) and
20 healthy controls were scanned using functional magnetic
resonance imaging. Participants performed an emotional
oddball task in which infrequently presented circle targets
required detection while sad and neutral pictures were
irrelevant novel distractors. Hemodynamic responses were
compared for targets, sad distractors, and for targets that
followed sad or neutral distractors (Target-after-Sad and
Target-after-Neutral). Patients with MDD revealed attenuated
activation overall to targets in executive brain regions.
Behaviorally, MDD patients were slower in response to
Target-after-Sad than Target-after-Neutra stimuli. Patients
also revealed a reversed activation pattern from controls in
response to this contrast in the left anterior cingulate,
insula, right inferior frontal gyrus (IFG), and bilateral
middle frontal gyrus. Those patients who engaged the right
IFG more during Target-after-Neutral stimuli responded
faster to targets, confirming a role of this region in
coping with emotional distraction. The results provide
direct evidence of an alteration in the neural systems that
interplay cognition with mood in MDD.},
Language = {eng},
Doi = {10.1016/j.pscychresns.2007.10.004},
Key = {fds276308}
}
@article{fds276283,
Author = {Lynch, TR and Rosenthal, MZ and Smoski, MJ},
Title = {Dialectical behavior therapy: Efficacy, mechanisms, and
application},
Journal = {Psychiatric Times},
Volume = {25},
Number = {2},
Pages = {76-77+78},
Year = {2008},
Month = {February},
ISSN = {0893-2905},
Key = {fds276283}
}
@article{fds276307,
Author = {Cheavens, JS and Lynch, TR and Smoski, MJ},
Title = {Response to the van Alphen et al. 'reaction to "treatment of
older adults with co-morbid personality disorder and
depression: a dialectical behavior therapy
approach".},
Journal = {Int J Geriatr Psychiatry},
Volume = {22},
Number = {7},
Pages = {701-702},
Year = {2007},
Month = {July},
ISSN = {0885-6230},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17600779},
Keywords = {Age Factors • Aged • Behavior Therapy •
Comorbidity • Depressive Disorder • Humans •
Personality Assessment • Personality Disorders •
Treatment Outcome • diagnosis • methods* •
psychology • therapy*},
Doi = {10.1002/gps.1843},
Key = {fds276307}
}
@article{fds276282,
Author = {Chapman, AL and Lynch, TR and Rosenthal, MZ and Cheavens, JS and Smoski,
MJ and Krishnan, KRR},
Title = {Risk aversion among depressed older adults with obsessive
compulsive personality disorder},
Journal = {Cognitive Therapy and Research},
Volume = {31},
Number = {2},
Pages = {161-174},
Publisher = {Springer Nature},
Year = {2007},
Month = {April},
ISSN = {0147-5916},
Abstract = {Despite considerable research on depression in older adults,
few studies have included individuals with personality
disorders or have used laboratory tasks to examine
behavioral correlates of depression among older adults. This
study used the Bechara Gambling Task to examine the
hypothesis that depressed older adults with co-morbid
personality disorders (n = 59) would demonstrate greater
aversion to risk, when compared with older adult controls
without depression or personality disorders (n = 34).
Results indicated weak support for the notion that depressed
individuals are more risk averse than non-depressed
controls, and stronger support for the role of
obsessive-compulsive personality disorder (OCPD) in risk
aversion. Individuals with OCPD became considerably more
risk averse as the task progressed, compared with controls.
In addition, the severity of OCPD features, rather than
depression, accounted for increased risk aversion in
depressed older adults with OCPD. © 2007 Springer
Science+Business Media, LLC.},
Doi = {10.1007/s10608-006-9114-x},
Key = {fds276282}
}
@article{fds167095,
Title = {Chapman, A., Lynch, T.R., Rosenthal, M.Z., Cheavens, J.S.,
Smoski, M.J., & Krishnan, K.R.R. (2007). Risk aversion among
depressed older adults with obsessive compulsive personality
disorder. Cognitive Therapy and Research, 31,
161-174.},
Year = {2007},
Key = {fds167095}
}
@article{fds276306,
Author = {Smoski, MJ and Bachorowski, J-A},
Title = {Antiphonal laughter in developing friendships.},
Journal = {Ann N Y Acad Sci},
Volume = {1000},
Pages = {300-303},
Year = {2003},
Month = {December},
ISSN = {0077-8923},
url = {http://www.ncbi.nlm.nih.gov/pubmed/14766642},
Keywords = {Adult • Evolution* • Female • Friends* •
Humans • Laughter* • Male •
Phonation*},
Doi = {10.1196/annals.1280.030},
Key = {fds276306}
}
@article{fds276272,
Author = {Smoski, M and Bachorowski, J-A},
Title = {Antiphonal laughter between friends and strangers.},
Journal = {Cogn Emot},
Volume = {17},
Number = {2},
Pages = {327-340},
Publisher = {PSYCHOLOGY PRESS},
Year = {2003},
Month = {March},
ISSN = {0269-9931},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000180765800009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Abstract = {Drawing from an affect-induction model of laughter
(Bachorowski & Owren, 2001; Owren & Bachorowski, 2002), we
propose that "antiphonal" laughter--that is, laughter that
occurs during or immediately after a social partner's
laugh--is a behavioural manifestation of a conditioned
positive emotional response to another individual's laugh
acoustics. To test hypotheses concerning the occurrence of
antiphonal laughter, participants (n = 148) were tested as
part of either same- or mixed-sex friend or stranger dyads,
and were audiorecorded while they played brief games
intended to facilitate laugh production. An index of
antiphonal laughter for each dyad was derived using Yule's
Q. Significantly more antiphonal laughter was produced in
friend than in stranger dyads, and females in mixed-sex
dyads produced more antiphonal laughter than did their male
partners. Antiphonal laughter may therefore reflect a
mutually positive stance between social partners, and
function to reinforce shared positive affective
experiences.},
Doi = {10.1080/02699930302296},
Key = {fds276272}
}
@article{fds276303,
Author = {Blake, R and Turner, LM and Smoski, MJ and Pozdol, SL and Stone,
WL},
Title = {Visual recognition of biological motion is impaired in
children with autism.},
Journal = {Psychol Sci},
Volume = {14},
Number = {2},
Pages = {151-157},
Year = {2003},
Month = {March},
ISSN = {0956-7976},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12661677},
Keywords = {Attention* • Autistic Disorder • Child •
Child, Preschool • Concept Formation* • Female
• Humans • Male • Motion Perception* •
Pattern Recognition, Visual* • Perceptual Closure
• Problem Solving • Psychophysics • Reference
Values • Social Behavior • diagnosis •
psychology*},
Abstract = {Autistic children and typically developing control children
were tested on two visual tasks, one involving grouping of
small line elements into a global figure and the other
involving perception of human activity portrayed in
point-light animations. Performance of the two groups was
equivalent on the figure task, but autistic children were
significantly impaired on the biological motion task. This
latter deficit may be related to the impaired social skills
characteristic of autism, and we speculate that this deficit
may implicate abnormalities in brain areas mediating
perception of human movement.},
Doi = {10.1111/1467-9280.01434},
Key = {fds276303}
}
@article{fds276304,
Author = {Kaplan, PS and Bachorowski, J-A and Smoski, MJ and Hudenko,
WJ},
Title = {Infants of depressed mothers, although competent learners,
fail to learn in response to their own mothers'
infant-directed speech.},
Journal = {Psychol Sci},
Volume = {13},
Number = {3},
Pages = {268-271},
Year = {2002},
Month = {May},
ISSN = {0956-7976},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12009049},
Keywords = {Association Learning • Depressive Disorder •
Female • Humans • Infant • Learning •
Mother-Child Relations* • Speech • complications*
• physiology*},
Abstract = {Depressed mothers use less of the exaggerated prosody that
is typical of infant-directed (ID) speech than do
nondepressed mothers. We investigated the consequences of
this reduced perceptual salience in ID speech for infant
learning. Infants of nondepressed mothers readily learned
that their mothers' speech signaled a face, whereas infants
of depressed mothers failed to learn that their mothers'
speech signaled the face. Infants of depressed mothers did,
however, show strong learning in response to speech produced
by an unfamiliar nondepressed mother. These outcomes
indicate that the reduced perceptual salience of depressed
mothers' ID speech could lead to deficient learning in
otherwise competent learners.},
Doi = {10.1111/1467-9280.00449},
Key = {fds276304}
}
@article{fds276277,
Author = {Kaplan, PS and Bachorowski, J-A and Smoski, MJ and Zinser,
M},
Title = {Role of Clinical Diagnosis and Medication Use in Effects of
Maternal Depression on Infant-Directed Speech.},
Journal = {Infancy},
Volume = {2},
Number = {4},
Pages = {537-548},
Publisher = {WILEY},
Year = {2001},
Month = {October},
ISSN = {1525-0008},
Abstract = {Infant-directed (ID) speech was recorded from mothers as
they interacted with their 4- to 12-month-old infants.
Hierarchical regression analyses revealed that two
variables, age of the mother and mother's diagnosed
depression, independently accounted for significant
proportions of the variance in the extent of change in
fundamental frequency (ΔF0). Specifically, depressed
mothers produced ID speech with smaller ΔF0 than did
nondepressed mothers, and older mothers produced ID speech
with larger ΔF0 than did younger mothers. Mothers who were
taking antidepressant medication and who were diagnosed as
being in at least partial remission produced ID speech with
mean ΔF0 values that were comparable to those of
nondepressed mothers. These results demonstrate explicit
associations between major depressive disorder and an
acoustic attribute of ID speech that is highly salient to
young infants.},
Doi = {10.1207/S15327078IN0204_08},
Key = {fds276277}
}
@article{fds276302,
Author = {Bachorowski, JA and Smoski, MJ and Owren, MJ},
Title = {The acoustic features of human laughter.},
Journal = {J Acoust Soc Am},
Volume = {110},
Number = {3 Pt 1},
Pages = {1581-1597},
Year = {2001},
Month = {September},
ISSN = {0001-4966},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11572368},
Keywords = {Acoustics* • Female • Humans • Individuality
• Laughter* • Male • Mouth • Reaction
Time • Sex Characteristics • Voice •
physiology},
Abstract = {Remarkably little is known about the acoustic features of
laughter. Here, acoustic outcomes are reported for 1024
naturally produced laugh bouts recorded from 97 young adults
as they watched funny video clips. Analyses focused on
temporal features, production modes, source- and
filter-related effects, and indexical cues to laugher sex
and individual identity. Although a number of researchers
have previously emphasized stereotypy in laughter, its
acoustics were found now to be variable and complex. Among
the variety of findings reported, evident diversity in
production modes, remarkable variability in fundamental
frequency characteristics, and consistent lack of
articulation effects in supralaryngeal filtering are of
particular interest. In addition, formant-related filtering
effects were found to be disproportionately important as
acoustic correlates of laugher sex and individual identity.
These outcomes are examined in light of existing data
concerning laugh acoustics, as well as a number of
hypotheses and conjectures previously advanced about this
species-typical vocal signal.},
Doi = {10.1121/1.1391244},
Key = {fds276302}
}
%% Chapters in Books
@misc{fds342182,
Author = {Dichter, GS and Smoski, M and Henderson, RK and Dimidjian,
S},
Title = {Behavioral activation as a treatment for depression theory,
neurobiologic effects, and potential linkages to
resilience},
Pages = {211-226},
Booktitle = {The Resilience Handbook: Approaches to Stress and
Trauma},
Year = {2013},
Month = {January},
ISBN = {9780415699877},
Abstract = {Unipolar major depressive disorder (MDD) is a debilitating
condition with a lifetime prevalence rate of 17% (Kessler et
al., 1994). Recent epidemiological evidence indicates that
MDD is the 4th leading cause of disease burden and the
leading cause of disability-adjusted life years (Ustun,
Ayuso-Mateos, Chatterji, Mathers, & Murray, 2004) and is
associated with significant psychosocial and medical
morbidity and mortality (Kovacs, 1996). MDD is characterized
by a high rate of relapse, with approximately 40% of
patients reporting relapse within 2 years (Solomon et al.,
2000) and 85% within 15 years (Mueller et al., 1999). With
each new episode of major depression, the likelihood of
experiencing future episodes increases by 16% (Solomon et
al., 2000). Given the chronic nature of MDD, a critical goal
for treatment development is to target the core processes
that make an individual vulnerable to depressive episodes
and thus improve his/her resilience to future
depression.},
Doi = {10.4324/9780203135303},
Key = {fds342182}
}