Publications of G. Allan Johnson    :recent first  alphabetical  combined listing:

%% Books   
@book{fds268793,
   Author = {Badea, A and Johnson, GA},
   Title = {Magnetic resonance microscopy.},
   Journal = {Analytical Cellular Pathology},
   Volume = {35},
   Number = {4},
   Pages = {205-227},
   Booktitle = {Studies in Health Technology and Informatics},
   Publisher = {IOS Press Ebooks},
   Year = {2012},
   ISSN = {0926-9630},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/22142643},
   Abstract = {MRI, one of the major clinical imaging modalities, has
             gained an important role in studying small animal models,
             e.g., rats and mice. But imaging rodents comes with
             challenges, since the image resolution needs to be ~
             3000-times higher to resolve anatomical details at a level
             comparable to clinical imaging. A resolution on the order of
             100 microns or less redefines MR imaging as MR microscopy.
             We discuss in this chapter the basic components of the MR
             imaging chain, with a particular emphasis on small animal
             imaging demands: from hardware design to basic physical
             principles of MR image formation, and contrast mechanisms.
             We discuss special considerations of animal preparation for
             imaging, and staining methods to enhance contrast. Attention
             is given to factors that increase sensitivity, including
             exogenous contrast agents, high performance radiofrequency
             detectors, and advanced MR encoding sequences. Among these,
             diffusion tensor imaging and tractography add novel
             information on white matter tracts, helping to better
             understand important aspects of development and
             neurodegeneration. These developments open avenues for
             efficient phenotyping of small animal models, in vivo - to
             include anatomical as well as functional estimates, or
             ex-vivo - with exquisite anatomical detail. The need for
             higher resolution results in larger image arrays that need
             to be processed efficiently. We discuss image-processing
             approaches for quantitative characterization of animal
             cohorts, and building population atlases. High throughput is
             essential for these methods to become practical. We discuss
             current trends for increasing detector performance, the use
             of cryoprobes, as well as strategies for imaging multiple
             animals at the same time. Ultimately, the development of
             highly specific probes, with the possibility to be used in
             multimodal imaging, will offer new insights into histology.
             MRM, alone or in combination with other imaging modalities,
             will increase the knowledge of fundamental biological
             processes, help understanding the genetic basis of human
             diseases, and test pharmacological interventions.},
   Doi = {10.3233/ACP-2011-0050},
   Key = {fds268793}
}

@book{fds292752,
   Author = {Paxinos, G and Watson, C and Calabrese, E and Badea, A and Johnson,
             G},
   Title = {An MRI/DTI Atlas of the Rat Brain},
   Pages = {224 pages},
   Publisher = {Elsevier Academic Press},
   Year = {2015},
   Month = {May},
   ISBN = {978-0-12-417313-2},
   Abstract = {MRI/DTI Atlas of the Rat Brain offers two major enhancements
             when compared with earlier attempts to make MRI/DTI rat
             brain atlases. First, the spatial resolution at 25μm is
             considerably higher than previous data published. Secondly,
             the comprehensive set of MRI/DTI contrasts provided has
             enabled the authors to identify more than 80% of structures
             identified in The Rat Brain in Stereotaxic
             Coordinates.},
   Key = {fds292752}
}


%% Papers Published   
@article{9082523,
   Author = {Oldham, M. and Sakhalkar, H. and Oliver, T. and Ying Min
             Wang and Kirpatrick, J. and Yiting Cao and Badea, C. and Johnson, G.A. and Dewhirst, M.},
   Title = {Three-dimensional imaging of xenograft tumors using optical
             computed and emission tomography},
   Journal = {Med. Phys. (USA)},
   Volume = {33},
   Number = {9},
   Pages = {3193 - 202},
   url = {http://dx.doi.org/10.1118/1.2217109},
   Keywords = {bio-optics;biomedical optical imaging;cancer;cellular
             biophysics;computerised tomography;image
             reconstruction;proteins;tumours;},
   Abstract = {The physical basis and preliminary applications of optical
             computed tomography (optical-CT) and optical emission
             computed tomography (optical-ECT) are introduced, as new
             techniques with potential to provide unique 3D information
             on a variety of aspects of tumor structure and function. A
             particular focus here is imaging tumor micro-vasculature,
             and the spatial distribution of viable tumor cells, although
             the techniques have the potential for much wider
             application. The principle attractiveness of optical-CT and
             optical-ECT are that high resolution (<20 μm) and high
             contrast co-registered 3D images of structure and function
             can be acquired for relatively large intact samples. The
             unique combination of high contrast and resolution offers
             advantages over micro-CT and micro-MRI, and the lack of
             requirement for sectioning offers advantages over confocal
             microscopy, conventional microscopy, and histological
             sectioning techniques. Optical-CT/ECT are implemented using
             in-house custom apparatus and a commercial dissecting
             microscope capable of both transmission and fluorescence
             imaging. Basic studies to characterize imaging performance
             are presented. Negligible geometrical distortion and
             accurate reconstruction of relative attenuation coefficients
             was observed. Optical-CT and optical-ECT are investigated
             here by application to high resolution imaging of HCT116
             xenograft tumors, about 1 cc in dimension, which were
             transfected with constitutive red fluorescent protein (RFP).
             Tumor microvasculature was stained in vivo by tail vein
             injection of either passive absorbing dyes or active
             fluorescent markers (FITC conjugated lectin). Prior to
             imaging, the tumors were removed (ex vivo) and optically
             cleared in a key process to make the samples amenable to
             light transmission. The cleared tumors were imaged in three
             modes (i) optical-CT to image the 3D distribution of
             microvasculature as indicated by absorbing dye, (ii)
             optical-ECT using the FITC excitation and emission filter
             set, to determine microvasculature as indicated by
             lectin-endothelial binding, and (iii) optical-ECT using the
             DSRed2 filter set to determine the 3D distribution of viable
             tumor as indicated by RFP emission. A clear correlation was
             observed between the independent vasculature imaging modes
             (i) and (ii) and postimaging histological sections,
             providing substantial validation of the optical-CT and
             optical-ECT techniques. Strong correlation was also observed
             between the RFP imaging of mode iii, and modes i and ii,
             supporting the intuitive conclusion that well-perfused
             regions contain significant viable tumor. In summary,
             optical-CT and optical-ECT, when combined with new optical
             clearing techniques, represent powerful new imaging
             modalities with potential for providing unique information
             on the structure and function of tumors},
   Key = {9082523}
}

@article{fds132812,
   Author = {GA Johnson and F O'Foghludha},
   Title = {Simulation of mammographic x-ray spectra.},
   Journal = {Medical physics, UNITED STATES},
   Volume = {7},
   Number = {3},
   Pages = {189-95},
   ISSN = {0094-2405},
   Keywords = {Computers • Female • Humans • Mammography
             • Spectrometry, X-Ray Emission • Xeromammography
             • instrumentation • instrumentation* •
             methods},
   Abstract = {Attempts to simulate Mo-anode spectra for film mammography
             by using Mo filters with W-anode tubes have been reported by
             several workers, and others have generated W-like continua
             for xeromammographic purposes by heavy Al filtration of
             Mo-anode tubes. In the present work the success of these
             simulations was tested by Si(Li) spectrometric methods that
             measured the spectral shapes and the exposure levels.
             Comparisons of Mo-anode/Al-filter with W-anode/Al-filter
             combinations were made, and also of W-anode/M-filter with
             Mo-anode/Mo-folter combinations. In certain circumstance the
             spectral shape is moderately well simulated but in all cases
             the useful output is less in the simulations than in the
             original spectra. The general conclusion is that simulation
             is always less attractive than direct use of the desired
             anode.},
   Key = {fds132812}
}

@article{fds132854,
   Author = {LW Hedlund and DP Jones and EL Effmann and GA Johnson and WM Bates and JW
             Beck, W Wolfe and CE Putman},
   Title = {A computed tomographic study of the dog lung during
             hemorrhagic shock and after resuscitation.},
   Journal = {Investigative radiology, UNITED STATES},
   Volume = {16},
   Number = {6},
   Pages = {466-72},
   ISSN = {0020-9996},
   Keywords = {Animals • Dogs • Hemodynamic Processes • Lung
             • Resuscitation* • Shock, Hemorrhagic •
             Tomography, X-Ray Computed* • physiopathology •
             radiography*},
   Abstract = {A shock model was used to explore the capability of computed
             tomography (CT) to detect changes in lung density during
             hypovolemia and after resuscitation. The same level of the
             lower thorax was scanned repeatedly during base-line, shock
             (aortic pressure 60 mmHg), and after resuscitation with shed
             blood. The average baseline CT number (+/- SEM) for 5 areas
             of interest for four prone dogs was -754 +/- 16 (air =
             -1000, water = 0). This decreased 7.4% to -810 +/- 15 (P
             less than .05) during shock. After resuscitation CT density
             was -773 +/- 17 or 2.5% less than baseline (P greater than
             .1). A dorsal to ventral gradient of increasing CT density
             during baseline was maintained in all five areas during
             shock and post-resuscitation. From baseline to shock there
             were also significant changes in heart rate, mean aortic
             pressure, cardiac output, and vascular volume. Extravascular
             lung volume after resuscitation was equal to baseline
             volume. We conclude that CT is sufficiently sensitive to
             detect rapid physiological changes leading to increased or
             decreased lung density.},
   Key = {fds132854}
}

@article{fds132770,
   Author = {PM Silverman and GA Johnson and M Korobkin and WM
             Thompson},
   Title = {High-resolution multiplanar CT images of the
             larynx.},
   Journal = {Investigative radiology, UNITED STATES},
   Volume = {17},
   Number = {6},
   Pages = {634-7},
   ISSN = {0020-9996},
   Keywords = {Humans • Larynx • Models, Structural •
             Tomography, X-Ray Computed • methods* •
             radiography*},
   Abstract = {The standard technique for computed tomographic evaluation
             of the larynx utilizes 5-mm contiguous transaxial sections.
             Multiplanar images reformatted with these sections have not
             been of clinical use. We have evaluated the practicality of
             utilizing coronal and sagittal reformatted images produced
             from contiguous 1.5-mm transaxial sections. The technique of
             rapid sequential scanning with automatic table
             incrementation allows 36 contiguous thin section scans to be
             acquired in less than 9 minutes. Phantom studies showed a
             marked improvement in spatial resolution with thin section
             reconstructions. Preliminary clinical evaluation shows
             visualization of smaller structures with improved edge
             definition of both low- and high-contrast
             structures.},
   Key = {fds132770}
}

@article{fds132888,
   Author = {WM Thompson and WC Meyers and M Shaw and M Bates and GA Johnson and LW
             Hedlund},
   Title = {Gallbladder density and iodine concentration in humans
             during oral cholecystography. A comparison of iopanoic acid
             and iopronic acid.},
   Journal = {Investigative radiology, UNITED STATES},
   Volume = {17},
   Number = {6},
   Pages = {621-8},
   ISSN = {0020-9996},
   Keywords = {Administration, Oral • Bile Acids and Salts •
             Cholecystography* • Clinical Trials • Contrast
             Media • Double-Blind Method • Gallbladder •
             Humans • Iodine • Iodobenzenes • Iopanoic
             Acid • administration & dosage* •
             analysis},
   Abstract = {A comparison of two oral cholecystopaques, iopanoic acid
             (Telepaque) and iopronic acid (Oravue), was performed using
             normal volunteers. Using a double-blind crossover design,
             comparisons were made between the degree of gallbladder
             opacification and the amount of iodine recovered from the
             gallbladder. Bile was collected via a double lumen
             intestinal tube before, during, and after stimulating
             gallbladder contraction. There were no differences between
             the two agents in terms of opacification or iodine
             concentration. Only 19% of the administered dose of either
             agent was recovered, and the maximum iodine concentration in
             bile was 10 mg I/ml. The results suggest that this technique
             has merit for future comparative studies of agents
             concentrated in the gallbladder.},
   Key = {fds132888}
}

@article{fds132892,
   Author = {KK Ford and ER Heinz and GA Johnson and BD Drayer and PJ
             Dubois},
   Title = {Low-cost digital subtraction angiography.},
   Journal = {AJNR. American journal of neuroradiology, UNITED
             STATES},
   Volume = {3},
   Number = {4},
   Pages = {448-51},
   ISSN = {0195-6108},
   Keywords = {Angiography • Humans • Radiographic Image
             Enhancement • Subtraction Technique • Videotape
             Recording • economics • methods*},
   Key = {fds132892}
}

@article{fds132908,
   Author = {GA Johnson and KJ Barsuhn and JM McCall},
   Title = {Minoxidil sulfate, a metabolite of minoxidil.},
   Journal = {Drug metabolism and disposition: the biological fate of
             chemicals, UNITED STATES},
   Volume = {11},
   Number = {5},
   Pages = {507-8},
   ISSN = {0090-9556},
   Keywords = {Animals • Bile • Chromatography, High Pressure
             Liquid • Female • Minoxidil • Pyrimidines
             • Rats • Rats, Inbred Strains • analogs &
             derivatives • metabolism • metabolism*},
   Key = {fds132908}
}

@article{fds132753,
   Author = {JD Godwin and GA Johnson and EK Fram},
   Title = {A phantom for testing ECG-gated computed tomography of the
             heart.},
   Journal = {Investigative radiology, UNITED STATES},
   Volume = {19},
   Number = {4},
   Pages = {279-83},
   ISSN = {0020-9996},
   Keywords = {Electrocardiography* • Heart • Humans •
             Models, Structural* • Myocardial Contraction •
             Tomography, X-Ray Computed • methods* •
             radiography*},
   Abstract = {A mechanical phantom has been built to evaluate
             electrocardiographically gated computed tomography of the
             heart. The phantom simulates the heart in terms of cyclic
             changes in chamber dimensions and wall thickness. Rate and
             excursion are variable, and the cavity of the chamber can be
             filled with liquid contrast media of different degrees of
             radio-opacity. Preliminary experiments with a prototypic
             gating system are described.},
   Key = {fds132753}
}

@article{fds132821,
   Author = {MA Brown and GA Johnson},
   Title = {Transition metal-chelate complexes as relaxation modifiers
             in nuclear magnetic resonance.},
   Journal = {Medical physics, UNITED STATES},
   Volume = {11},
   Number = {1},
   Pages = {67-72},
   ISSN = {0094-2405},
   Keywords = {Chlorides* • Edetic Acid • Ferric Compounds •
             Gadolinium • Magnetic Resonance Spectroscopy* •
             Manganese • Manganese Compounds*},
   Abstract = {Studies are reported of relaxation modifiers for use in
             nuclear magnetic resonance (NMR) imaging systems. Chelate
             complexes of transition metal salts are under investigation
             to determine their ability to reduce the spin-lattice
             relaxation time (T1) of the nucleus under observation and to
             reduce the toxicity of the metal ion. The
             ethylenediaminetetraacetate (EDTA) complexes of FeCl3,
             GdCl3, and MnCl2 are not as effective as the respective
             salts in reducing T1 of water protons at 90 MHz. For Mn,
             this diminution in ability is offset by a significant
             reduction in toxicity. Explanations for this loss of
             effectiveness are discussed.},
   Key = {fds132821}
}

@article{fds132783,
   Author = {HD Sostman and JC Gore and MW Flye and GA Johnson and RJ
             Herfkens},
   Title = {Time course and mechanism of alterations in proton
             relaxation during liver regeneration in the
             rat.},
   Journal = {Hepatology (Baltimore, Md.), UNITED STATES},
   Volume = {5},
   Number = {4},
   Pages = {538-43},
   ISSN = {0270-9139},
   Keywords = {Animals • Body Water • Lipids • Liver •
             Liver Regeneration* • Magnetic Resonance Spectroscopy
             • Male • Protons • Rats • Rats, Inbred
             Strains • Spectrum Analysis • Spleen • Time
             Factors • analysis • anatomy & histology •
             anatomy & histology* • diagnostic use* •
             methods},
   Abstract = {We studied the proton T1 and T2, water and lipid content of
             regenerating rat liver from 1 to 7 days after 70%
             hepatectomy. Liver from normal and sham-operated animals and
             splenic tissue from all animals were studied as controls. In
             vivo proton spectroscopy and imaging of liver was performed
             in a separate group of control and posthepatectomy rats. The
             T2 of regenerating liver, but not of sham or normal control
             liver, was prolonged. Changes in T1, relative to normal
             tissue, were found in liver and spleen of both operated
             groups. Lipid content, assessed both by extraction of tissue
             samples and by in vivo spectroscopy, was increased in
             regenerating tissue but not in controls. Water content was
             similarly increased in regenerating liver tissue. Changes in
             water and lipid content appeared to contribute to the
             alterations in proton relaxation which we
             observed.},
   Key = {fds132783}
}

@article{fds132890,
   Author = {LW Hedlund and GA Johnson and JP Karis and EL Effmann},
   Title = {MR "microscopy" of the rat thorax.},
   Journal = {Journal of computer assisted tomography, UNITED
             STATES},
   Volume = {10},
   Number = {6},
   Pages = {948-52},
   ISSN = {0363-8715},
   Keywords = {Animals • Electrocardiography • Fourier Analysis
             • Magnetic Resonance Spectroscopy • Male •
             Rats • Rats, Inbred Strains • Thorax •
             anatomy & histology* • diagnostic use* •
             instrumentation • methods},
   Abstract = {High resolution images can be obtained from anywhere in the
             body of small animals with magnetic resonance combined with
             cardiac gating and scan synchronous ventilation. We used
             these methods to examine the intrathoracic anatomy of the
             rat. Anesthetized rats were intubated and ventilated in
             synchrony with imaging acquisition. Images were obtained in
             a 1 m bore, 1.5 T system fitted with a 28 cm diameter high
             field gradient coil and a 5 cm radio-frequency coil. We used
             cardiac gated, three-dimensional spin warp acquisitions.
             Eight contiguous slices (2.5 mm thick) were obtained
             simultaneously. In addition to visualizing major vessels and
             cardiac chambers, cardiac valves and papillary muscles were
             clearly demonstrated. Major pulmonary vessels and peripheral
             parenchyma were also seen. These results demonstrate MR
             "microscopy" can be used to image all major cardiopulmonary
             structures in the rat with respect to selected times of the
             cardiac cycle. This capability for noninvasive "microscopy"
             opens new avenues for cardiopulmonary research using well
             characterized rodent models.},
   Key = {fds132890}
}

@article{fds132798,
   Author = {SA Suddarth and GA Johnson and RH Sherrier and CE
             Ravin},
   Title = {Performance of high-resolution monitors for digital chest
             imaging.},
   Journal = {Medical physics, UNITED STATES},
   Volume = {14},
   Number = {2},
   Pages = {253-7},
   ISSN = {0094-2405},
   Keywords = {Computer Systems* • Humans • Radiographic Image
             Enhancement • Radiography, Thoracic •
             instrumentation*},
   Abstract = {High-resolution cathode-ray tubes (CRT's) are currently the
             most viable soft-copy display for digital radiography. We
             present here methods for measuring large-area contrast ratio
             and detail contrast ratio. A two-dimensional charge coupled
             device (ccd) array signal-averaged with a video frame buffer
             permits linear microradiometric measure of individual beam
             lines. Results from three different 1000-line monitors
             demonstrate the shift variance of resolution. The detail
             contrast ratio (or modulation depth) was found to vary from
             100% to less than 10% across the face of one CRT. Dynamic
             focus in both the horizontal and vertical deflection
             circuitry proved effective in reducing this shift variance.
             Comparisons of three phosphors demonstrate the utility of
             long persistence phosphors (P164) for static display in
             producing brighter images with less flicker. Recommendations
             for CRT design and selection for high-resolution digital
             radiography are included.},
   Key = {fds132798}
}

@article{fds132805,
   Author = {HE Cline and WE Lorensen and RJ Herfkens and GA Johnson and GH
             Glover},
   Title = {Vascular morphology by three-dimensional magnetic resonance
             imaging.},
   Journal = {Magnetic resonance imaging, UNITED STATES},
   Volume = {7},
   Number = {1},
   Pages = {45-54},
   ISSN = {0730-725X},
   Keywords = {Adult • Algorithms* • Animals • Blood Vessels
             • Dogs • Head and Neck Neoplasms • Heart
             • Humans • Image Processing, Computer-Assisted
             • Magnetic Resonance Imaging • Male • anatomy
             & histology • anatomy & histology* • diagnosis
             • methods • methods*},
   Abstract = {A three-dimensional examination of blood vessels is provided
             using MR data from seven cases. The vascular surfaces are
             constructed with an algorithm that automatically follows the
             selected artery or vein and generates a projected
             three-dimensional gradient shaded image. Fast 3DFT pulse
             sequences were optimized to enhance the time-of-flight
             contrast of the intravascular region. By increasing the
             surface threshold value in a three-dimensional head study,
             the flesh of a patient's face was peeled away to demonstrate
             the superfacial temporal artery. Gated cardiac images show
             the great vessels and cardiac chambers. A three-dimensional
             view of the aorta shows an irregular surface in the vicinity
             of an adrenal tumor. 3D MR exams provide a non-invasive
             technique for assessing vascular morphology in a clinical
             setting.},
   Key = {fds132805}
}

@article{fds132785,
   Author = {JH Maki and H Benveniste, JR MacFall and CA Piantadosi and GA
             Johnson},
   Title = {MR imaging of microcirculation in rat brain: correlation
             with carbon dioxide-induced changes in blood
             flow.},
   Journal = {Journal of magnetic resonance imaging : JMRI, UNITED
             STATES},
   Volume = {1},
   Number = {6},
   Pages = {673-81},
   ISSN = {1053-1807},
   Keywords = {Animals • Artifacts • Brain • Carbon Dioxide
             • Cerebral Cortex • Cerebrovascular Circulation
             • Corpus Striatum • Female • Image
             Enhancement • Lasers • Linear Models •
             Magnetic Resonance Imaging • Microcirculation •
             Models, Structural • Motion • Rats • Rats,
             Inbred Strains • blood supply • blood supply*
             • blood* • diagnostic use • methods* •
             physiology*},
   Abstract = {Considerable interest has been shown in developing a
             magnetic resonance (MR) imaging technique with quantitative
             capability in the evaluation of tissue microcirculation
             ("perfusion"). In the present study, the
             flow-dephased/flow-compensated (FD/FC) technique is
             evaluated for measuring rat cerebral blood flow (CBF) under
             nearly optimal laboratory conditions. Imaging was performed
             on a 2.0-T system equipped with shielded gradient coils. Rat
             CBF was varied by manipulating arterial carbon dioxide
             pressure (PaCO2). In parallel experiments, optimized MR
             imaging studies (seven rats) were compared with laser
             Doppler flowmetry (LDF) studies (nine rats). LDF values
             showed a high degree of correlation between CBF and PaCO2,
             agreeing with results in the literature. MR imaging values,
             while correlating with PaCO2, showed considerable scatter.
             The most likely explanation is unavoidable rat motion during
             the requisite long imaging times. Because of this motion
             sensitivity, the FD/FC technique cannot provide a
             quantitative measure of CBF. It can, however, provide a
             qualitative picture.},
   Key = {fds132785}
}

@article{fds132810,
   Author = {TW Malisch and LW Hedlund and SA Suddarth and GA Johnson},
   Title = {MR microscopy at 7.0 T: effects of brain
             iron.},
   Journal = {Journal of magnetic resonance imaging : JMRI, UNITED
             STATES},
   Volume = {1},
   Number = {3},
   Pages = {301-5},
   ISSN = {1053-1807},
   Keywords = {Animals • Brain Chemistry • Extrapyramidal Tracts
             • Iron • Magnetic Resonance Imaging* • Rats
             • Rats, Inbred Strains • Substantia Nigra •
             anatomy & histology* • physiology*},
   Abstract = {The T2 of brain tissue is known to be field dependent,
             decreasing as B0 increases. Previous studies have attributed
             reduced T2 in the structures of the extrapyramidal motor
             system (EPMS) to high iron concentrations. The present study
             was designed to manipulate physiologic iron concentrations
             and study the effects on T2 and on the field dependence of
             T2 at 7.0 T in whole formalin-fixed brains. A rat model was
             devised in which iron concentrations in the structures of
             interest were altered by diet manipulation. Cerebral
             structures with different iron content were imaged and T2
             measured with MR microscopy at both 2.0 and 7.0 T. T2 of all
             tissues was shorter by 40%-60% at 7.0 T. Although some
             dependence of T2 on iron concentration was evident, it was
             less than expected. The strongest correlation was in the
             substantia nigra. The highest-resolution studies, at 30 x 30
             x 50 microns, show the myelin bundles in many of the EPMS
             structures but not in the substantia nigra. From these data,
             it appears that T2 at greater field strengths depends more
             on susceptibility-induced spin dephasing imposed by
             diffusion through the tissue microstructure than on the
             presence of iron.},
   Key = {fds132810}
}

@article{fds132880,
   Author = {JH Maki and H Benveniste, JR MacFall and GA Johnson},
   Title = {Maximization of contrast-to-noise ratio to distinguish
             diffusion and microcirculatory flow.},
   Journal = {Journal of magnetic resonance imaging : JMRI, UNITED
             STATES},
   Volume = {1},
   Number = {1},
   Pages = {39-46},
   ISSN = {1053-1807},
   Keywords = {Animals • Cerebral Infarction • Diffusion* •
             Magnetic Resonance Imaging • Microcirculation* •
             Models, Structural • Rats • diagnosis* •
             methods* • physiopathology},
   Abstract = {Optimization of the contrast-to-noise ratio (CNR) is
             described for microcirculation magnetic resonance (MR)
             imaging techniques based on flow-compensated/flow-dephased
             sequences, both with and without even-echo rephasing. The
             authors present the most advantageous manner of applying
             flow-dephased gradients, such that dephasing is maximal
             while diffusion losses are minimal. The theoretical
             considerations include phase, diffusion, echo time, and
             bandwidth in the determination of the optimal parameters for
             microcirculation imaging. Studies in phantoms consisting of
             stationary and flowing copper sulfate in Sephadex columns
             demonstrate the validity of the calculations. Optimized in
             vivo images of a rat stroke model demonstrate the potential
             of the flow-compensated/flow-dephased technique and the
             importance of optimizing CNR.},
   Key = {fds132880}
}

@article{fds132846,
   Author = {BR Smith and EL Effmann and GA Johnson},
   Title = {MR microscopy of chick embryo vasculature.},
   Journal = {Journal of magnetic resonance imaging : JMRI, UNITED
             STATES},
   Volume = {2},
   Number = {2},
   Pages = {237-40},
   ISSN = {1053-1807},
   Keywords = {Animals • Blood Vessels • Chick Embryo •
             Magnetic Resonance Imaging • embryology* •
             methods*},
   Abstract = {Six-day-old chick embryos were examined with magnetic
             resonance microscopy after vascular perfusion fixation and
             perfusion with gadolinium-doped gelatin to high-light the
             developing vascular anatomy. Gadolinium gelatin, with its
             short T1, provided a source of signal contrast within the
             vessels. The entire embryo was embedded in gelatin to
             minimize susceptibility artifacts that are prevalent at the
             high field strength (7.0 T) used. A series of single-section
             spin-echo images were acquired with various TRs to determine
             the optimal imaging sequence for a three-dimensional (3D)
             acquisition. The combination of gadolinium gelatin in the
             vascular spaces, gelatin embedding of the specimen, and
             optimal acquisition parameters yielded a 3D stack of
             high-resolution images that was readily reconstructed and
             rendered to effectively demonstrate the developing thoracic
             vessels in the embryo.},
   Key = {fds132846}
}

@article{fds132871,
   Author = {X Zhou and ZP Liang and GP Cofer and CF Beaulieu and SA Suddarth and GA
             Johnson},
   Title = {Reduction of ringing and blurring artifacts in fast
             spin-echo imaging.},
   Journal = {Journal of magnetic resonance imaging : JMRI, UNITED
             STATES},
   Volume = {3},
   Number = {5},
   Pages = {803-7},
   ISSN = {1053-1807},
   Keywords = {Artifacts* • Image Enhancement • Magnetic
             Resonance Imaging • Models, Structural • methods
             • methods*},
   Abstract = {A simple method was devised to reduce ringing and blurring
             artifacts caused by discontinuous T2 weighting of k-space
             data in fast spin-echo magnetic resonance (MR) imaging. The
             method demodulates the weighting function along the
             phase-encoding direction by using multiple T2 values derived
             from a set of non-phase-encoded echoes obtained from an
             extra excitation. The performance of this method was
             evaluated by computer simulations and experiments, which
             confirmed its capability of effectively reducing or, in some
             cases, even completely removing the ringing and blurring
             artifacts. The results also show that the proposed method
             produces better results than other artifact reduction
             methods. The method is particularly useful at high magnetic
             field strengths (7.1-9.4 T) and with strong gradients (> 20
             G/cm) used in MR microscopy, in which the apparent T2 values
             are short for most tissues. The authors expect that the
             proposed method will find useful applications in various
             fast spin-echo pulse sequences.},
   Key = {fds132871}
}

@article{fds132819,
   Author = {BR Smith and E Linney and DS Huff and GA Johnson},
   Title = {Magnetic resonance microscopy of embryos.},
   Journal = {Computerized medical imaging and graphics : the official
             journal of the Computerized Medical Imaging Society, UNITED
             STATES},
   Volume = {20},
   Number = {6},
   Pages = {483-90},
   ISSN = {0895-6111},
   Keywords = {Anatomy, Artistic • Animals • Contrast Media
             • Databases, Factual • Embryo • Embryonic and
             Fetal Development* • Humans • Image Processing,
             Computer-Assisted • Magnetic Resonance Imaging* •
             Medical Illustration • Mice • Microscopy •
             anatomy & histology • anatomy & histology* •
             embryology},
   Abstract = {We demonstrate that magnetic resonance (MR) microscopy
             provides a mechanism to investigate normal and abnormal
             developmental anatomy in a non-destructive and
             distortion-free manner. Techniques for the fixation,
             embedding, perfusion and image acquisition of embryos
             between 3 and 30 mm crown rump length are described. We
             describe the perfusion of a contrast agent to enhance images
             of the developing embryonic vasculature. Data are acquired
             as three-dimensional isotropic arrays which permit images to
             be reformatted retrospectively in any plane. The data are
             available for archiving, distributing and for
             post-acquisition manipulations. MR microscopy is a fast
             technique for producing three-dimensional reconstructions
             and is free from registration and sectioning
             artifacts.},
   Key = {fds132819}
}

@article{fds132841,
   Author = {M Delnomdedieu and LW Hedlund and GA Johnson and RR
             Maronpot},
   Title = {Magnetic resonance microscopy--a new tool for the
             toxicologic pathologist.},
   Journal = {Toxicologic pathology, UNITED STATES},
   Volume = {24},
   Number = {1},
   Pages = {36-44},
   ISSN = {0192-6233},
   Keywords = {Animals • Brain Ischemia • Disease Models, Animal
             • Kidney • Liver • Magnetic Resonance Imaging
             • Microscopy • Rats • blood supply •
             drug effects • methods* • pathology •
             pathology*},
   Abstract = {Parallel to its many applications in medical imaging,
             magnetic resonance (MR) microscopy is a potentially powerful
             tool in toxicologic pathology. Because of the intrinsic
             qualities of MR microscopy (noninvasiveness,
             3-dimensionality, and slicing in any chosen plane), the
             scientist has a new means by which to investigate different
             types of lesions based on differential contrast. By choosing
             appropriate proton stains to probe the state of the water in
             tissues, organ structure and vasculature can be seen and
             progressive lesion development can be followed in a given
             animal. This paper discusses toxicologic pathology
             applications for MR microscopy and compares MR microscopy
             with conventional histopathology using a time-course study
             of bromobenzene-induced hepatotoxicity in rats. Hematoxylin
             and eosin (H&E)-stained histological sections are compared
             with MR microscopy images from fixed tissue blocks to
             demonstrate one of the applications of MR microscopy to
             toxicologic pathology. The results indicate that MR
             microscopy is as sensitive as conventional H&E staining in
             detecting bromobenzene-induced hepatic lesions.},
   Key = {fds132841}
}

@article{fds132877,
   Author = {H Qiu and LW Hedlund and SL Gewalt and H Benveniste and TM Bare and GA
             Johnson},
   Title = {Progression of a focal ischemic lesion in rat brain during
             treatment with a novel glycine/NMDA antagonist: an in vivo
             three-dimensional diffusion-weighted MR microscopy
             study.},
   Journal = {Journal of magnetic resonance imaging : JMRI, UNITED
             STATES},
   Volume = {7},
   Number = {4},
   Pages = {739-44},
   ISSN = {1053-1807},
   Keywords = {Animals • Brain • Brain Ischemia • Female
             • Image Processing, Computer-Assisted • Magnetic
             Resonance Imaging • Pyridazines • Quinolines
             • Rats • Rats, Inbred F344 • Receptors,
             Glycine • Time Factors • antagonists & inhibitors*
             • drug therapy* • methods • methods* •
             pathology • pathology* • therapeutic
             use*},
   Abstract = {Stroke was induced in two groups of anesthetized rats by
             occlusion of the middle cerebral artery (MCA) and
             ipsilateral common carotid artery. Group 1 (control)
             received vehicle and group 2 received the glycine
             N-methyl-D-aspartate (NMDA) antagonist ZD9379. Stroke volume
             was assessed by three-dimensional diffusion-weighted MR
             microscopy at 2.5 and 6 hours of MCA occlusion. At 2.5
             hours, stroke volumes were identical in the two groups. At 6
             hours, stroke volumes had increased by 15% in the control
             group; in contrast, the treated group showed a 40% reduced
             stroke volume. Conclusions from this in vivo study were as
             follows: (a) our technique allows more efficient and
             accurate measurement of stroke volume with an improvement in
             resolution over a previous method; (b) the ability to
             measure stroke volume at multiple time points shows volume
             change and assessment of time dependency of drug treatment;
             (c) at 6 hours, the glycine antagonist ZD9379 reduced stroke
             volume by 40%.},
   Key = {fds132877}
}

@article{fds132858,
   Author = {H Benveniste and H Qui and LW Hedlund and F D'Ercole and GA
             Johnson},
   Title = {Spinal cord neural anatomy in rats examined by in vivo
             magnetic resonance microscopy.},
   Journal = {Regional anesthesia and pain medicine, UNITED
             STATES},
   Volume = {23},
   Number = {6},
   Pages = {589-99},
   ISSN = {1098-7339},
   Keywords = {Animals • Biomechanics • Catheters, Indwelling
             • Cervical Vertebrae • Coloring Agents •
             Contrast Media • Diffusion • Edema • Epidural
             Space • Feasibility Studies • Female •
             Follow-Up Studies • Injections, Spinal • Ischemia
             • Longitudinal Studies • Lumbar Vertebrae •
             Magnetic Resonance Imaging • Microscopy •
             Neurilemma • Peripheral Nervous System Diseases •
             Rats • Rats, Inbred F344 • Regional Blood Flow
             • Spinal Cord • Spinal Cord Diseases • Spinal
             Nerves • anatomy & histology • anatomy &
             histology* • blood supply • diagnosis •
             diagnostic use • instrumentation • methods* •
             pathology • physiology},
   Abstract = {BACKGROUND AND OBJECTIVES: Magnetic resonance microscopy
             (MRM) is a technique that is worthwhile for
             anesthesiologists because it allows spinal cord and plexus
             anatomy to be visualized three dimensionally and followed
             over time in the same animal. For example, the long-term
             effect of indwelling intrathecal or plexus catheters can be
             studied in situ, and convective and diffusive forces within
             intrathecal, epidural, or nerve sheath spaces can be
             investigated. Further, diffusion-weighted MRM, which
             measures an "apparent diffusion coefficient" (ADC), can be
             used to track the presence of ischemia, hypoperfusion, or
             cytotoxic edema. This study investigates problems associated
             with the use of in vivo MRM for spinal cord and peripheral
             nerve studies in the rat. METHODS: Twenty-one anesthetized
             female Fisher CDF rats were used. Group 1 (n=7) was used for
             anatomic three-dimensional studies. Groups 2 (n=4), 3 (n=4),
             and 4 (n=6) were used for measurements of the ADC. Group 2
             served as controls, group 3 received lumbar intrathecal
             catheters, and group 4 received cervical intrathecal
             catheters. RESULTS: Cervical spine, lumbar spine, and spinal
             nerves and ganglia were accurately visualized with MRM. As a
             rule, spinal cord gray and white matter were better
             demonstrated using diffusion-weighted proton stains. By
             contrast, T2-weighted proton staining superiorly
             demonstrated structures surrounding the spinal cord. In
             groups 3 and 4, indwelling intrathecal catheters did not
             affect the spinal cord ADC, indicating normal blood flow and
             no cytotoxic edema. Contrast studies revealed nonhomogeneous
             distribution of contrast predominately in the lateral and
             ventral intrathecal space. CONCLUSION: Three-dimensional
             diffusion-weighted MRM displays cervical and lumbar spine
             anatomy accurately in vivo. Apparent diffusion coefficients
             measurements are feasible in rat cervical spinal cord with
             intrathecal catheters. Spinal cord ADCs are unaffected by
             intrathecal catheters, indicating normal spinal cord
             perfusion.},
   Key = {fds132858}
}

@article{fds132767,
   Author = {BR Smith and DS Huff and GA Johnson},
   Title = {Magnetic resonance imaging of embryos: an Internet resource
             for the study of embryonic development.},
   Journal = {Computerized medical imaging and graphics : the official
             journal of the Computerized Medical Imaging Society, UNITED
             STATES},
   Volume = {23},
   Number = {1},
   Pages = {33-40},
   ISSN = {0895-6111},
   Keywords = {Embryo • Humans • Image Processing,
             Computer-Assisted* • Internet* • Magnetic
             Resonance Imaging* • anatomy & histology*},
   Abstract = {The recent amassing of gene expression data to study
             development in mammals has led to an increased demand for
             access to human embryological data. The difficulty of
             obtaining well-preserved human embryos presents an important
             challenge to studying human development. The
             Multidimensional Human Embryo project is generating an image
             data set based on magnetic resonance microscopy of specimens
             from the highly respected Carnegie Collection of Human
             Embryos. The data are available from a web site to
             facilitate the work of clinicians, investigators, and
             students of human development. A consequence of the project
             will be to preserve a highly respected, yet impermanent,
             collection of human embryos and minimize the need for
             collecting new specimens.},
   Key = {fds132767}
}

@article{fds132840,
   Author = {H Benveniste and H Qui and LW Hedlund and PC Hüttemeier and SM Steele and GA Johnson},
   Title = {In vivo diffusion-weighted magnetic resonance microscopy of
             rat spinal cord: effect of ischemia and intrathecal
             hyperbaric 5% lidocaine.},
   Journal = {Regional anesthesia and pain medicine, UNITED
             STATES},
   Volume = {24},
   Number = {4},
   Pages = {311-8},
   ISSN = {1098-7339},
   Keywords = {Anesthetics, Local • Animals • Blood Pressure
             • Catheterization • Dose-Response Relationship,
             Drug • Female • Heart Rate • Injections,
             Spinal • Ischemia • Lidocaine • Magnetic
             Resonance Imaging • Microscopy • Rats • Rats,
             Inbred F344 • Spinal Cord • anatomy & histology*
             • blood supply* • chemically induced* •
             cytology • diagnosis* • drug effects •
             methods • pathology • physiopathology •
             toxicity*},
   Abstract = {BACKGROUND AND OBJECTIVES: Pathophysiologic mechanisms
             underlying persistent neurologic deficits after continuous
             spinal anesthesia using hyperbaric 5% lidocaine are still
             not well understood. It has been suggested that high-dose
             intrathecal lidocaine induces irreversible conduction block
             and even ischemia in white matter tracts by breakdown of the
             blood-nerve barrier. In this study, we use
             diffusion-weighted magnetic resonance microscopy to
             characterize the effect of intrathecal hyperbaric 5%
             lidocaine in rat spinal cord. The parameter measured with
             DWM, is an "apparent diffusion coefficient," (ADC), which
             can be used to exclude the presence of ischemia. METHODS:
             Female Fischer CDF rats were used. Group 1 (n = 5) was
             exposed to ischemia, group 2 (n = 7) was exposed to
             intrathecal 5% hyperbaric lidocaine, and group 3 (n = 5) was
             exposed to intrathecal 7.5% glucose. Diffusion-weighted MR
             images in group 1 were acquired before and after ischemia
             induced by cardiac arrest and in groups 2 and 3 rats prior
             to and during perfusion of the spinal catheter with either
             5% hyperbaric lidocaine or 7.5% glucose. RESULTS: Ischemia
             decreased the ADC by 40% in gray matter and by 30% in white
             matter of spinal cord. Continuous intrathecal anesthesia
             with hyperbaric 5% lidocaine did not affect the spinal cord
             ADC. Further, 7.5% intrathecal glucose had no effect on ADCs
             in gray or white matter of spinal cord. CONCLUSIONS:
             Ischemia reduced the ADC in both spinal cord white and gray
             matter. Hyperbaric 5% lidocaine did not affect the spinal
             cord ADC during the first 1.5 hours. We suggest that 5%
             hyperbaric lidocaine does not induce irreversible neurologic
             deficits by causing spinal cord ischemia.},
   Key = {fds132840}
}

@article{fds132837,
   Author = {DS Lester and PS Pine and M Delnomdedieu and JN Johannessen and GA
             Johnson},
   Title = {Virtual neuropathology: three-dimensional visualization of
             lesions due to toxic insult.},
   Journal = {Toxicologic pathology, UNITED STATES},
   Volume = {28},
   Number = {1},
   Pages = {100-4},
   ISSN = {0192-6233},
   Keywords = {Animals • Brain • Image Processing,
             Computer-Assisted • Kainic Acid • Magnetic
             Resonance Imaging • Microscopy • Nervous System
             Diseases • Neurotoxicity Syndromes • Neurotoxins
             • Oxidopamine • Parkinson Disease, Secondary
             • Rats • Sympatholytics • analogs &
             derivatives • chemically induced • methods* •
             pathology • pathology* • toxicity},
   Abstract = {A first-pass approach incorporating high-field magnetic
             resonance imaging (MRI) was used for rapid detection of
             neuropathologic lesions in fixed rat brains. This inherently
             3-dimensional and nondestructive technique provides
             high-resolution, high-contrast images of fixed neuronal
             tissue in the absence of sectioning or staining. This
             technique, magnetic resonance microscopy (MRM), was used to
             identify diverse lesions in 2 well-established rat
             neurotoxicity models. The intrinsic contrast in the images
             delineated lesions that were identified using a battery of
             histologic stains, some of which would not be used in
             routine screening. Furthermore, the MRM images provided the
             locations of lesions, which were verified upon subsequent
             sectioning and staining of the same samples. The inherent
             contrast generated by water properties is exploited in MRM
             by choosing suitable pulse sequences, or proton stains. This
             approach provides the potential for a comprehensive initial
             MRM screen for neurotoxicity in preclinical models with the
             capability for extrapolation to clinical analyses using
             classical MRI.},
   Key = {fds132837}
}

@article{fds132894,
   Author = {WP Segars and BM Tsui and EC Frey and GA Johnson and SS
             Berr},
   Title = {Development of a 4-D digital mouse phantom for molecular
             imaging research.},
   Journal = {Molecular imaging and biology : MIB : the official
             publication of the Academy of Molecular Imaging, United
             States},
   Volume = {6},
   Number = {3},
   Pages = {149-59},
   ISSN = {1536-1632},
   Keywords = {Animals • Image Processing, Computer-Assisted •
             Mice • Models, Anatomic* • Models, Animal* •
             Phantoms, Imaging* • Tomography, Emission-Computed,
             Single-Photon • Tomography, X-Ray Computed •
             anatomy & histology* • instrumentation •
             instrumentation* • physiology},
   Abstract = {PURPOSE: We develop a realistic and flexible 4-D digital
             mouse phantom and investigate its usefulness in molecular
             imaging research. METHODS: Organ shapes were modeled with
             non-uniform rational B-spline (NURBS) surfaces based on
             high-resolution 3-D magnetic resonance microscopy (MRM)
             data. Cardiac and respiratory motions were modeled based on
             gated magnetic resonance imaging (MRI) data obtained from
             normal mice. Pilot simulation studies in single-photon
             emission computed tomography (SPECT) and X-ray computed
             tomography (CT) were performed to demonstrate the utility of
             the phantom. RESULTS: NURBS are an efficient and flexible
             way to accurately model the anatomy and cardiac and
             respiratory motions for a realistic 4-D digital mouse
             phantom. The phantom is capable of producing realistic
             molecular imaging data from which imaging devices and
             techniques can be evaluated. CONCLUSION: The phantom
             provides a unique and useful tool in molecular imaging
             research. It can be used in the development of new imaging
             instrumentation, image acquisition strategies, and image
             processing and reconstruction methods.},
   Key = {fds132894}
}

@article{fds132895,
   Author = {RC Sills and DL Morgan and DW Herr and PB Little and NM George and TV Ton and NE Love and RR Maronpot and GA Johnson},
   Title = {Contribution of magnetic resonance microscopy in the 12-week
             neurotoxicity evaluation of carbonyl sulfide in Fischer 344
             rats.},
   Journal = {Toxicologic pathology, United States},
   Volume = {32},
   Number = {5},
   Pages = {501-10},
   ISSN = {0192-6233},
   Keywords = {Administration, Inhalation • Air Pollutants •
             Animals • Brain • Dose-Response Relationship, Drug
             • Female • Image Processing, Computer-Assisted
             • Inhalation Exposure • Magnetic Resonance
             Imaging* • Male • Microscopy • Neurotoxicity
             Syndromes • Rats • Rats, Inbred F344 •
             Recovery of Function • Sulfur Oxides •
             administration & dosage • drug effects* •
             etiology* • methods • pathology •
             toxicity*},
   Abstract = {In this carbonyl sulfide (COS) study, magnetic resonance
             microscopy (MRM) and detailed light microscopic evaluation
             effectively functioned in parallel to assure that the
             distribution and degree of pathology in the brain was
             accurately represented. MRM is a powerful imaging modality
             that allows for excellent identification of neuroanatomical
             structures coupled with the ability to acquire 200 or more
             cross-sectional images of the brain, and the ability to
             display them in multiple planes. F344 rats were exposed to
             200-600 ppm COS for up to 12 weeks. Prior to MRM, rats were
             anesthetized and cardiac perfused with McDowell Trump's
             fixative containing a gadolinium MR contrast medium. Fixed
             specimens were scanned at the Duke Center for In Vivo
             Microscopy on a 9.4 Tesla magnetic resonance system adapted
             explicitly for microscopic imaging. An advantage of MRM in
             this study was the ability to identify lesions in rats that
             appeared clinically normal prior to sacrifice and the
             opportunity to identify lesions in areas of the brain which
             would not be included in conventional studies. Other
             advantages include the ability to examine the brain in
             multiple planes (transverse, dorsal, sagittal) and obtain
             and save the MRM images in a digital format that allows for
             postexperimental data processing and manipulation. MRM
             images were correlated with neuroanatomical and
             neuropathological findings. All suspected MRM images were
             compared to corresponding H&E slides. An important aspect of
             this study was that MRM was critical in defining our
             strategy for sectioning the brain, and for designing
             mechanistic studies (cytochrome oxidase evaluations) and
             functional assessments (electrophysiology studies) on
             specifically targeted anatomical sites following COS
             exposure.},
   Key = {fds132895}
}

@article{fds157102,
   Author = {CT Badea and B Fubara and LW Hedlund and GA Johnson},
   Title = {4-D micro-CT of the mouse heart.},
   Journal = {Molecular imaging : official journal of the Society for
             Molecular Imaging, United States},
   Volume = {4},
   Number = {2},
   Pages = {110-6},
   ISSN = {1535-3508},
   Keywords = {Animals • Contrast Media • Heart • Iodine
             • Iopamidol • Mice • Mice, Inbred C57BL
             • Tomography, X-Ray Computed* •
             radiography*},
   Abstract = {PURPOSE: Demonstrate noninvasive imaging methods for in vivo
             characterization of cardiac structure and function in mice
             using a micro-CT system that provides high photon fluence
             rate and integrated motion control. MATERIALS AND METHODS:
             Simultaneous cardiac- and respiratory-gated micro-CT was
             performed in C57BL/6 mice during constant intravenous
             infusion of a conventional iodinated contrast agent
             (Isovue-370), and after a single intravenous injection of a
             blood pool contrast agent (Fenestra VC). Multiple phases of
             the cardiac cycle were reconstructed with contrast to noise
             and spatial resolution sufficient for quantitative
             assessment of cardiac function. RESULTS: Contrast
             enhancement with Isovue-370 increased over time with a
             maximum of approximately 500 HU (aorta) and 900 HU (kidney
             cortex). Fenestra VC provided more constant enhancement over
             3 hr, with maximum enhancement of approximately 620 HU
             (aorta) and approximately 90 HU (kidney cortex). The maximum
             enhancement difference between blood and myocardium in the
             heart was approximately 250 HU for Isovue-370 and
             approximately 500 HU for Fenestra VC. In mice with Fenestra
             VC, volumetric measurements of the left ventricle were
             performed and cardiac function was estimated by ejection
             fraction, stroke volume, and cardiac output. CONCLUSION:
             Image quality with Fenestra VC was sufficient for
             morphological and functional studies required for a
             standardized method of cardiac phenotyping of the
             mouse.},
   Key = {fds157102}
}

@article{fds174134,
   Author = {GW Fuller and GA Johnson},
   Title = {On the Question of Standard Methods for the Determination of
             the Numbers of Bacteria in Waters.},
   Journal = {Public health papers and reports},
   Volume = {25},
   Pages = {574-9},
   Year = {1899},
   ISSN = {0737-8769},
   Language = {eng},
   Key = {fds174134}
}

@article{fds174152,
   Author = {GW Fuller and GA Johnson},
   Title = {Some Points on the Differentiation and Classification of
             Water Bacteria.},
   Journal = {Public health papers and reports},
   Volume = {25},
   Pages = {580-6},
   Year = {1899},
   ISSN = {0737-8769},
   Language = {eng},
   Key = {fds174152}
}

@article{fds174279,
   Author = {GW Fuller and GA Johnson},
   Title = {On the Question of Standard Methods for the Determination of
             the Numbers of Bacteria in Waters.},
   Journal = {Public health papers and reports},
   Volume = {25},
   Pages = {574-579},
   Year = {1899},
   Language = {ENG},
   Key = {fds174279}
}

@article{fds174297,
   Author = {GW Fuller and GA Johnson},
   Title = {Some Points on the Differentiation and Classification of
             Water Bacteria.},
   Journal = {Public health papers and reports},
   Volume = {25},
   Pages = {580-586},
   Year = {1899},
   Language = {ENG},
   Key = {fds174297}
}

@article{fds174227,
   Author = {GW Fuller and GA Johnson},
   Title = {ON THE DIFFERENTIATION AND CLASSIFICATION OF WATER
             BACTERIA.},
   Journal = {The Journal of experimental medicine},
   Volume = {4},
   Number = {5-6},
   Pages = {609-626},
   Year = {1899},
   Month = {September},
   ISSN = {1540-9538},
   Language = {ENG},
   Key = {fds174227}
}

@article{fds174081,
   Author = {GW Fuller and GA Johnson},
   Title = {ON THE QUESTION OF STANDARD METHODS FOR THE DETERMINATION OF
             THE NUMBERS OF BACTERIA IN WATERS.},
   Journal = {Journal. Boston Society of Medical Sciences},
   Volume = {4},
   Number = {4},
   Pages = {85-86},
   Year = {1900},
   Month = {January},
   Language = {ENG},
   Key = {fds174081}
}

@article{fds174242,
   Author = {GW Fuller and GA Johnson},
   Title = {SOME POINTS OF THE DIFFERENTIATION AND CLASSIFICATION OF
             WATER BACTERIA.},
   Journal = {Journal. Boston Society of Medical Sciences},
   Volume = {4},
   Number = {4},
   Pages = {83-84},
   Year = {1900},
   Month = {January},
   Language = {ENG},
   Key = {fds174242}
}

@article{fds174069,
   Author = {GA Johnson and WR Copeland and AE Kimberly},
   Title = {The Relative Applicability of Current Methods for the
             Determination of Putrescibility in Sewage
             Effluents.},
   Journal = {Public health papers and reports},
   Volume = {31},
   Number = {Pt 2},
   Pages = {80-96},
   Year = {1905},
   Language = {ENG},
   Key = {fds174069}
}

@article{fds174091,
   Author = {GA Johnson and AE Kimberly},
   Title = {A Comparative Review of Current Methods for the
             Determination of Organic Matter in Sewage.},
   Journal = {Public health papers and reports},
   Volume = {31},
   Number = {Pt 2},
   Pages = {97-108},
   Year = {1905},
   Language = {ENG},
   Key = {fds174091}
}

@article{fds174197,
   Author = {GA Johnson and WR Copeland and AE Kimberly},
   Title = {The Relative Applicability of Current Methods for the
             Determination of Putrescibility in Sewage
             Effluents.},
   Journal = {Public health papers and reports},
   Volume = {31},
   Number = {Pt 2},
   Pages = {80-96},
   Year = {1905},
   ISSN = {0737-8769},
   Language = {eng},
   Key = {fds174197}
}

@article{fds174249,
   Author = {GA Johnson and AE Kimberly},
   Title = {A Comparative Review of Current Methods for the
             Determination of Organic Matter in Sewage.},
   Journal = {Public health papers and reports},
   Volume = {31},
   Number = {Pt 2},
   Pages = {97-108},
   Year = {1905},
   ISSN = {0737-8769},
   Language = {eng},
   Key = {fds174249}
}

@article{fds174086,
   Author = {GA Johnson},
   Title = {HYPOCHLORITE TREATMENT OF PUBLIC WATER SUPPLIES: ITS
             ADAPTIBILITY AND LIMITATIONS.},
   Journal = {Journal. American Public Health Association},
   Volume = {1},
   Number = {8},
   Pages = {562-74},
   Year = {1911},
   Month = {August},
   ISSN = {0273-1975},
   Language = {eng},
   Key = {fds174086}
}

@article{fds174158,
   Author = {GA Johnson},
   Title = {HYPOCHLORITE TREATMENT OF PUBLIC WATER SUPPLIES: ITS
             ADAPTIBILITY AND LIMITATIONS.},
   Journal = {Journal. American Public Health Association},
   Volume = {1},
   Number = {8},
   Pages = {562-574},
   Year = {1911},
   Month = {August},
   Language = {ENG},
   Key = {fds174158}
}

@article{fds174268,
   Author = {GA Johnson},
   Title = {SHELLFISH CONSERVATION AND SEWAGE DISPOSAL.},
   Journal = {American journal of public health (New York, N.Y. :
             1912)},
   Volume = {4},
   Number = {11},
   Pages = {965-8},
   Year = {1914},
   Month = {November},
   ISSN = {0271-4353},
   Language = {eng},
   Key = {fds174268}
}

@article{fds174195,
   Author = {GA JOHNSON},
   Title = {An arsine problem: engineering notes.},
   Journal = {American Industrial Hygiene Association quarterly},
   Volume = {14},
   Number = {3},
   Pages = {188-90},
   Year = {1953},
   Month = {September},
   ISSN = {0096-820X},
   Language = {eng},
   Key = {fds174195}
}

@article{fds174269,
   Author = {GA JOHNSON and CR KISTLER and RH McCLUER},
   Title = {Metabolism of exogenous sialic acid in the
             rat.},
   Journal = {Proceedings of the Society for Experimental Biology and
             Medicine. Society for Experimental Biology and Medicine (New
             York, N.Y.)},
   Volume = {106},
   Pages = {124-7},
   Year = {1961},
   Month = {January},
   ISSN = {0037-9727},
   Language = {eng},
   Key = {fds174269}
}

@article{fds174287,
   Author = {GA JOHNSON and RH McCLUER},
   Title = {Relation of sialic acid to Rho (D) antigen.},
   Journal = {Proceedings of the Society for Experimental Biology and
             Medicine. Society for Experimental Biology and Medicine (New
             York, N.Y.)},
   Volume = {107},
   Pages = {692-4},
   Year = {1961},
   Month = {July},
   ISSN = {0037-9727},
   Keywords = {ANTIEMETICS/therapy* • CARBOHYDRASES/pharmacology*
             • NEURAMINIC ACIDS/pharmacology*},
   Language = {eng},
   Key = {fds174287}
}

@article{fds174206,
   Author = {GA JOHNSON and RH MCCLUER},
   Title = {ISOLATION AND ANALYSIS OF MONO-, DI-, AND
             TRISIALOGANGLIOSIDES.},
   Journal = {Biochimica et biophysica acta},
   Volume = {70},
   Pages = {487-90},
   Year = {1963},
   Month = {August},
   ISSN = {0006-3002},
   Keywords = {BRAIN* • CHROMATOGRAPHY* • EXPERIMENTAL LAB STUDY*
             • GANGLIOSIDES* • HEXOSAMINES* • HEXOSES*
             • NEURAMINIC ACIDS* • NEUROCHEMISTRY*},
   Language = {eng},
   Key = {fds174206}
}

@article{fds174183,
   Author = {GA JOHNSON and RH MCCLUER},
   Title = {PERIODATE OXIDATION STUDIES OF HUMAN BRAIN
             GANGLIOSIDES.},
   Journal = {Biochimica et biophysica acta},
   Volume = {84},
   Pages = {587-95},
   Year = {1964},
   Month = {October},
   ISSN = {0006-3002},
   Keywords = {CHROMATOGRAPHY* • GALACTOSE* • GANGLIOSIDES*
             • GLUCOSE* • NEURAMINIC ACIDS* •
             OXIDATION-REDUCTION* • PERIODIC ACIDS*},
   Language = {eng},
   Key = {fds174183}
}

@article{fds174299,
   Author = {MC DODD and NJ BIGLEY and GA JOHNSON and RH MCCLUER},
   Title = {CHEMICAL ASPECTS ON INHIBITORS OF RH-O(D)
             ANTIBODY.},
   Journal = {Nature},
   Volume = {204},
   Pages = {549-52},
   Year = {1964},
   Month = {November},
   ISSN = {0028-0836},
   Keywords = {ANTIBODY FORMATION* • BRAIN CHEMISTRY* •
             CHEMISTRY* • EXPERIMENTAL LAB STUDY* •
             GANGLIOSIDES* • HEMAGGLUTINATION INHIBITION TESTS*
             • PEPTIDES* • PSEUDOMONAS* • RABBITS* •
             RH FACTORS*},
   Language = {eng},
   Key = {fds174299}
}

@article{fds174078,
   Author = {GA Johnson and PA Van Pernis},
   Title = {How pathology kept pace with expansion.},
   Journal = {Modern hospital},
   Volume = {105},
   Number = {5},
   Pages = {105-7},
   Year = {1965},
   Month = {November},
   ISSN = {0026-783X},
   Keywords = {Hospital Design and Construction* • Humans •
             Illinois • Laboratories* • Pathology*},
   Language = {eng},
   Key = {fds174078}
}

@article{fds174199,
   Author = {GA Johnson and DW Baldridge},
   Title = {The orthodontic gospel according to Begg.},
   Journal = {Journal of the Louisiana Dental Association},
   Volume = {24},
   Number = {1},
   Pages = {5-8},
   Year = {1966},
   ISSN = {0024-6786},
   Keywords = {Dentistry • Orthodontics, Corrective},
   Language = {eng},
   Key = {fds174199}
}

@article{fds174121,
   Author = {GA Johnson},
   Title = {Obstetric nursing is for men, too.},
   Journal = {The American journal of nursing},
   Volume = {66},
   Number = {12},
   Pages = {2714-5},
   Year = {1966},
   Month = {December},
   ISSN = {0002-936X},
   Keywords = {Female • Humans • Nurses, Male* • Obstetrical
             Nursing* • Pregnancy},
   Language = {eng},
   Key = {fds174121}
}

@article{fds174309,
   Author = {GA Johnson and EG Kim and W Veldkamp and R Russell},
   Title = {Difference in oral effectiveness of two tyrosine hydroxylase
             inhibitors.},
   Journal = {Biochemical pharmacology},
   Volume = {16},
   Number = {2},
   Pages = {401-3},
   Year = {1967},
   Month = {February},
   ISSN = {0006-2952},
   Keywords = {Animals • Body Weight • Brain • Brain
             Chemistry* • Dextroamphetamine • Diet •
             Dopamine • Eating • Enzymes • Male •
             Methyltyrosines • Mice • Movement •
             Norepinephrine • Oxidoreductases • Reserpine
             • Serotonin • Tyrosine • analysis • drug
             effects • pharmacology • pharmacology*},
   Language = {eng},
   Key = {fds174309}
}

@article{fds174311,
   Author = {W Veldkamp and HH Keasling and GA Johnson and WA Freyburger and RJ
             Collins},
   Title = {Pharmacologic studies with 3-(phenylpropoxy)guanidine
             cyclohexanesulfamate.},
   Journal = {Journal of pharmaceutical sciences},
   Volume = {56},
   Number = {7},
   Pages = {829-33},
   Year = {1967},
   Month = {July},
   ISSN = {0022-3549},
   Keywords = {Animals • Appetite • Appetite Depressants •
             Behavior, Animal • Blood Pressure • Body Weight
             • Brain • Cats • Cyclohexanes •
             Dextroamphetamine • Dogs • Drug Synergism •
             Electric Stimulation • Electrophysiology •
             Electroshock • Guanidines • Mice • Movement
             • Norepinephrine • Reserpine • Serotonin
             • Temperature • Tryptamines • drug effects
             • drug effects* • metabolism • pharmacology
             • pharmacology* • toxicity},
   Language = {eng},
   Key = {fds174311}
}

@article{fds174139,
   Author = {GA Johnson and EG Kim and PA Platz and MM Mickelson},
   Title = {Comparative aspects of tyrosine hydroxylase and tryptophan
             hydroxylase inhibition: arterenones and dihydroxyphenylacetamide
             (H 22-54).},
   Journal = {Biochemical pharmacology},
   Volume = {17},
   Number = {3},
   Pages = {403-10},
   Year = {1968},
   Month = {March},
   ISSN = {0006-2952},
   Keywords = {Acetophenones • Adrenal Medulla • Amides •
             Animals • Brain • Cattle • Iron •
             Mast-Cell Sarcoma • Methyltyrosines • Mice •
             Mixed Function Oxygenases* • Norepinephrine •
             Phenylacetates* • Phenylalanine • Sarcoma,
             Experimental • Tritium • Tryptophan •
             Tyrosine • antagonists & inhibitors • enzymology
             • enzymology* • metabolism • pharmacology
             • pharmacology*},
   Language = {eng},
   Key = {fds174139}
}

@article{fds174136,
   Author = {W Veldkamp and GA Johnson and HH Keasling},
   Title = {Studies on the effects of reserpine in mice as influenced by
             its diluent.},
   Journal = {Journal of pharmaceutical sciences},
   Volume = {57},
   Number = {4},
   Pages = {613-7},
   Year = {1968},
   Month = {April},
   ISSN = {0022-3549},
   Keywords = {Amines • Animals • Appetite Depressants •
             Benzphetamine • Blepharoptosis • Brain •
             Citrates • Dextroamphetamine • Drug Antagonism
             • Hydrogen-Ion Concentration • Locomotion •
             Male • Methylcellulose • Mice •
             Norepinephrine • Phenethylamines • Propylamines
             • Reserpine • Serotonin • Sulfates •
             Suspensions • Time Factors • Vehicles* •
             administration & dosage* • chemically induced •
             drug effects • metabolism • pharmacology •
             pharmacology*},
   Language = {eng},
   Key = {fds174136}
}

@article{fds174270,
   Author = {GA Johnson and EG Kim and SJ Boukma},
   Title = {Mechanism of norepinephrine depletion by
             5-hydroxytryptophan.},
   Journal = {Proceedings of the Society for Experimental Biology and
             Medicine. Society for Experimental Biology and Medicine (New
             York, N.Y.)},
   Volume = {128},
   Number = {2},
   Pages = {509-12},
   Year = {1968},
   Month = {June},
   ISSN = {0037-9727},
   Keywords = {5-Hydroxytryptophan • Animals • Brain • Brain
             Chemistry • Carbon Isotopes • Injections,
             Intraperitoneal • Injections, Intravenous • Male
             • Methyltyrosines • Norepinephrine • Rats
             • Tyrosine • antagonists & inhibitors* •
             biosynthesis • metabolism • metabolism* •
             pharmacology • pharmacology*},
   Language = {eng},
   Key = {fds174270}
}

@article{fds174258,
   Author = {GA Johnson and RA Lahti and TL Lemke and RV Heinzelman},
   Title = {Effect of alpha-methyl-5-hydroxytryptophan ethyl ester upon
             tissue norepinephrine levels in rats and
             mice.},
   Journal = {Biochemical pharmacology},
   Volume = {18},
   Number = {7},
   Pages = {1593-600},
   Year = {1969},
   Month = {July},
   ISSN = {0006-2952},
   Keywords = {5-Hydroxytryptophan • Adrenal Glands • Animals
             • Brain • Brain Chemistry • Esters •
             Mice • Mixed Function Oxygenases • Myocardium
             • Norepinephrine • Rats • Time Factors •
             Tyrosine • administration & dosage • analysis
             • analysis* • enzymology • metabolism •
             pharmacology • pharmacology*},
   Language = {eng},
   Key = {fds174258}
}

@article{fds174273,
   Author = {GA Johnson and SJ Boukma and EG Kim},
   Title = {Inhibition of dopamine beta-hydroxylase by aromatic and
             alkyl thioureas.},
   Journal = {The Journal of pharmacology and experimental
             therapeutics},
   Volume = {168},
   Number = {2},
   Pages = {229-34},
   Year = {1969},
   Month = {August},
   ISSN = {0022-3565},
   Keywords = {Animals • Brain Chemistry • Disulfiram •
             Dopamine • Mice • Mixed Function Oxygenases •
             Norepinephrine • Rats • Thiourea • Tyramine
             • administration & dosage • analysis •
             antagonists & inhibitors* • metabolism •
             pharmacology • pharmacology*},
   Language = {eng},
   Key = {fds174273}
}

@article{fds174200,
   Author = {GA Johnson and SJ Boukma and EG Kim},
   Title = {In vivo inhibition of dopamine beta-hydroxylase by
             1-phenyl-3-(2-thiazolyl)-2-thiourea (U-14,624).},
   Journal = {The Journal of pharmacology and experimental
             therapeutics},
   Volume = {171},
   Number = {1},
   Pages = {80-7},
   Year = {1970},
   Month = {January},
   ISSN = {0022-3565},
   Keywords = {Adrenal Glands • Adrenalectomy • Animals •
             Brain • Brain Chemistry • Carbon Isotopes •
             Catecholamines • Disulfiram • Dopamine •
             Dopamine Antagonists* • Hydrolases • Male •
             Metaraminol • Mice • Monoamine Oxidase Inhibitors
             • Myocardium • Norepinephrine • Rats •
             Species Specificity • Thiazoles • Thiourea •
             Time Factors • Tritium • Tyrosine • analysis
             • antagonists & inhibitors* • biosynthesis •
             drug effects • enzymology • metabolism •
             metabolism* • pharmacology • pharmacology* •
             physiology},
   Language = {eng},
   Key = {fds174200}
}

@article{fds174087,
   Author = {GA Johnson and SJ Boukma and PA Platz},
   Title = {2-mercaptobenzothiazole, an inhibitor of dopamine
             beta-hydroxylase.},
   Journal = {The Journal of pharmacy and pharmacology},
   Volume = {22},
   Number = {9},
   Pages = {710-2},
   Year = {1970},
   Month = {September},
   ISSN = {0022-3573},
   Keywords = {Animals • Brain Chemistry • Dopamine • Heart
             • Metaraminol • Mice • Mixed Function
             Oxygenases • Motor Activity • Myocardium •
             Norepinephrine • Rats • Thiazoles • analysis
             • antagonists & inhibitors* • drug effects •
             pharmacology • pharmacology*},
   Language = {eng},
   Key = {fds174087}
}

@article{fds174209,
   Author = {P Luly and GA Johnson and L Bolis and BA Pethica},
   Title = {The agglutination of erythrocytes by calcium phosphate
             sols.},
   Journal = {Biochimica et biophysica acta},
   Volume = {233},
   Number = {3},
   Pages = {730-3},
   Year = {1971},
   Month = {June},
   ISSN = {0006-3002},
   Keywords = {Animals • Calcium Chloride • Calcium Phosphates*
             • Cattle • Chemistry, Physical • Colloids
             • Electrophoresis • Erythrocytes* •
             Hemagglutination • Humans • Phosphates •
             Physicochemical Phenomena • Rats • Salmonidae
             • Sodium • Spectrophotometry},
   Language = {eng},
   Key = {fds174209}
}

@article{fds174097,
   Author = {GA Johnson and D Robinson and M Hornung},
   Title = {Unique bedrock and soils associated with the Teesdale
             flora.},
   Journal = {Nature},
   Volume = {232},
   Number = {5311},
   Pages = {453-6},
   Year = {1971},
   Month = {August},
   ISSN = {0028-0836},
   url = {http://dx.doi.org/10.1038/232453a0},
   Language = {eng},
   Doi = {10.1038/232453a0},
   Key = {fds174097}
}

@article{fds174154,
   Author = {HE Williams and GA Johnson and LH Smith Jr},
   Title = {The renal clearance of oxalate in normal subjects and
             patients with primary hyperoxaluria.},
   Journal = {Clinical science},
   Volume = {41},
   Number = {3},
   Pages = {213-8},
   Year = {1971},
   Month = {September},
   ISSN = {0009-9287},
   Keywords = {Adult • Carbon Isotopes • Creatinine • Humans
             • Kidney • Male • Metabolism, Inborn Errors
             • Oxalates • blood • metabolism •
             metabolism* • urine*},
   Language = {eng},
   Key = {fds174154}
}

@article{fds174222,
   Author = {GA Johnson and EG Kim and SJ Boukma and D Lednicer and GA
             Youngdale},
   Title = {Inhibition of dopamine -hydroxylase by 5-phenoxymethyl-2-oxazolidinethiones.},
   Journal = {Journal of medicinal chemistry},
   Volume = {15},
   Number = {3},
   Pages = {327-9},
   Year = {1972},
   Month = {March},
   ISSN = {0022-2623},
   Keywords = {Adrenal Glands • Animals • Brain • Brain
             Chemistry • Cattle • Dopamine beta-Hydroxylase
             • Food Habits • Male • Mice • Mice,
             Inbred Strains • Mixed Function Oxygenases • Motor
             Activity • Norepinephrine • Oxazoles •
             Phenols • Structure-Activity Relationship •
             analysis • antagonists & inhibitors • antagonists
             & inhibitors* • drug effects • enzymology •
             pharmacology • pharmacology*},
   Language = {eng},
   Key = {fds174222}
}

@article{fds174275,
   Author = {GA Johnson and EG Kim and SJ Boukma},
   Title = {5-hydroxyindole levels in rat brain after inhibition of
             dopamine -hydroxylase.},
   Journal = {The Journal of pharmacology and experimental
             therapeutics},
   Volume = {180},
   Number = {3},
   Pages = {539-46},
   Year = {1972},
   Month = {March},
   ISSN = {0022-3565},
   Keywords = {Administration, Oral • Animals • Brain •
             Brain Chemistry • Circadian Rhythm • Disulfiram
             • Dopamine beta-Hydroxylase • Hydroxyindoleacetic
             Acid • Injections, Intraperitoneal • Male •
             Methyltyrosines • Mixed Function Oxygenases •
             Monoiodotyrosine • Norepinephrine • Pargyline
             • Rats • Rats, Inbred Strains • Serotonin
             • Thiazoles • Thiourea • Time Factors •
             administration & dosage • analysis • analysis*
             • antagonists & inhibitors • antagonists &
             inhibitors* • biosynthesis • drug effects •
             enzymology* • pharmacology • pharmacology*},
   Language = {eng},
   Key = {fds174275}
}

@article{fds174145,
   Author = {GA Johnson and SJ Boukma and RA Lahti and J Mathews},
   Title = {Cyclic AMP and phosphodiesterase in synaptic vesicles from
             mouse brain.},
   Journal = {Journal of neurochemistry},
   Volume = {20},
   Number = {5},
   Pages = {1387-92},
   Year = {1973},
   Month = {May},
   ISSN = {0022-3042},
   Keywords = {Animals • Brain • Brain Chemistry* • Cattle
             • Cell Fractionation • Centrifugation, Density
             Gradient • Cyclic AMP • Male • Mice •
             Microscopy, Electron • Myocardium • Phosphoric
             Diester Hydrolases • Synaptic Vesicles • Tritium
             • analysis* • cytology • enzymology},
   Language = {eng},
   Key = {fds174145}
}

@article{fds174179,
   Author = {GA Johnson and EG Kim},
   Title = {Increase of brain levels of tryptophan induced by inhibition
             of dopamine beta-hydroxylase (EC 1.14.2.1).},
   Journal = {Journal of neurochemistry},
   Volume = {20},
   Number = {6},
   Pages = {1761-4},
   Year = {1973},
   Month = {June},
   ISSN = {0022-3042},
   Keywords = {Animals • Brain • Cresols • Disulfides •
             Dopamine beta-Hydroxylase • Hydroxyindoleacetic Acid
             • Imidazoles • Kinetics • Male •
             Norepinephrine • Oxazoles • Phenylthiourea •
             Rats • Serotonin • Thiazoles • Tryptophan
             • antagonists & inhibitors* • drug effects •
             metabolism • metabolism* • pharmacology},
   Language = {eng},
   Key = {fds174179}
}

@article{fds174238,
   Author = {GA Johnson and SM Jalal},
   Title = {DDT-induced chromosomal damage in mice.},
   Journal = {The Journal of heredity},
   Volume = {64},
   Number = {1},
   Pages = {7-8},
   Year = {1973},
   Month = {June},
   ISSN = {0022-1503},
   Keywords = {Animals • Chromatids • Chromosome Aberrations*
             • Chromosomes • DDT • Mice • Mice,
             Inbred BALB C • Mutagens • drug effects •
             drug effects* • pharmacology*},
   Language = {eng},
   Key = {fds174238}
}

@article{fds174247,
   Author = {PF Von Voigtlander and SJ Boukma and GA Johnson},
   Title = {Dopaminergic denervation supersensitivity and dopamine
             stimulated adenyl cyclase activity.},
   Journal = {Neuropharmacology},
   Volume = {12},
   Number = {11},
   Pages = {1081-6},
   Year = {1973},
   Month = {November},
   ISSN = {0028-3908},
   Keywords = {Adenylate Cyclase • Animals • Apomorphine •
             Corpus Striatum • Cyclic AMP • Dopamine •
             Dose-Response Relationship, Drug • Hydroxydopamines
             • Male • Methyltyrosines • Mice • Nerve
             Endings • Receptors, Drug • Stimulation, Chemical
             • Sympathectomy • biosynthesis • drug effects
             • enzymology • metabolism • metabolism*
             • pharmacology • pharmacology* •
             physiology},
   Language = {eng},
   Key = {fds174247}
}

@article{fds174232,
   Author = {GA Johnson},
   Title = {The interview workshop.},
   Journal = {Journal of medical education},
   Volume = {49},
   Number = {1},
   Pages = {75-7},
   Year = {1974},
   Month = {January},
   ISSN = {0022-2577},
   Keywords = {Education, Continuing* • Family Practice • Female
             • Humans • Interview, Psychological* • Male
             • Michigan • Minority Groups • Primary Health
             Care • Rural Population • Schools, Medical* •
             Social Problems • Students, Medical • Videotape
             Recording},
   Language = {eng},
   Key = {fds174232}
}

@article{fds292760,
   Author = {Johnson, GA},
   Title = {Free radicals formed by exposure of pyrimidine solids to
             sodium atoms: an electron spin resonance
             study.},
   Journal = {Proceedings of the National Academy of Sciences of
             USA},
   Volume = {72},
   Number = {3},
   Pages = {974-978},
   Year = {1975},
   Month = {March},
   ISSN = {0027-8424},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/165496},
   Keywords = {Alloxan • Bromouracil • Cytosine • Electron
             Spin Resonance Spectroscopy • Fluorouracil • Free
             Radicals • Pyrimidines* • Sodium* • Thymine
             • Uracil • analogs & derivatives},
   Abstract = {Sodium atoms have been deposited on various pyrimidine
             powders under high vacuum at 77 degrees K and the electron
             spin resonance spectra of the resulting free radicals have
             been observed. Generally, the spectra show that the electron
             of the Na goes into a molecular orbital of the pyrimidine
             ring and the Na+ ions become attached to a carbonyl oxygen
             of the resulting pyrimidine anion. In 5-fluorouracil and
             5-chlorouracil, however, the halogen is evidently abstracted
             by the Na to form NaF or NaC1 and the neutral uracil
             radical. Thymine shows evidence for H-addition radicals as
             well as the Na+-[thymine]-complex. The H source for the
             addition radicals may be an H-2-0 impurity in the sample,
             with which the Na atoms combine to release the H atoms. In
             addition to a resonance with g equals 2.00 from the
             pyrimidine anion radical, broad resonances with g greater
             than 2 were observed for 5-bromouracil, 5-chlorouracil and
             5-iodouracil, as well as for alloxan and cytosine. These
             resonances, generally unstable at room temperature, are
             believed to arise from electrons trapped in interstitial
             sties or vacancies in the lattice.},
   Language = {eng},
   Key = {fds292760}
}

@article{fds174168,
   Author = {RS Dhariwal and RK Fitch and CL Lavelle and GA Johnson},
   Title = {Artefacts observed on dental tissues during ion etching in a
             scanning electron microscope.},
   Journal = {Journal of anatomy},
   Volume = {122},
   Number = {Pt 1},
   Pages = {133-40},
   Year = {1976},
   Month = {September},
   ISSN = {0021-8782},
   Keywords = {Dental Amalgam • Dental Enamel • Dental Materials
             • Dentin • Histological Techniques • Humans
             • Ions • Microscopy, Electron, Scanning •
             Tooth • methods* • ultrastructure •
             ultrastructure*},
   Language = {eng},
   Key = {fds174168}
}

@article{fds174114,
   Author = {RS Dhariwal and GA Johnson and RM Browne and SL Rowles},
   Title = {Reprecipitation phenomena arising during the preparation of
             demineralised sections. III Scanning electron microscopic
             examinations of secondary calcium phosphate
             deposits.},
   Journal = {Stain technology},
   Volume = {51},
   Number = {6},
   Pages = {293-9},
   Year = {1976},
   Month = {November},
   ISSN = {0038-9153},
   Keywords = {Calcium Phosphates • Decalcification Technique* •
             Dentin • Humans • Microradiography •
             Microscopy, Electron, Scanning • Tooth • Tooth
             Calcification* • X-Ray Diffraction • radiography
             • ultrastructure*},
   Abstract = {Sections of teeth partly demineralized in 10% formic acid
             were examined by X-ray diffraction, microradiography and
             scanning electron microscopy. In the undemineralized
             circumpulpal dentin, the tubules were empty, lying in a
             matrix containing hydroxyapatite. In the "plume" areas of
             remineralisation, the tubules were filled with mineral
             deposits. X-ray diffraction revealed the presence of
             brushite and monetite in these areas. In the outer layers of
             dentin the tubules were empty, lying in a matrix containing
             some residual hydroxyapatite. These findings confirmed that
             the remineralisation process occurred within the dentinal
             tubules.},
   Language = {eng},
   Key = {fds174114}
}

@article{fds174180,
   Author = {DG Johnston and GA Johnson and KG Alberti},
   Title = {Hepatotrophic factors: implications for diabetes
             mellitus.},
   Journal = {Ciba Foundation symposium},
   Number = {55},
   Pages = {357-73},
   Year = {1977},
   ISSN = {0300-5208},
   Keywords = {Adenine Nucleotides • Animals • Diabetes
             Complications • Diabetes Mellitus • Diabetes
             Mellitus, Experimental • Dogs • Fatty Liver •
             Glucose • Humans • Injections, Subcutaneous •
             Insulin • Liver • Liver Cirrhosis • Liver
             Glycogen • Liver Regeneration • Portal Vein •
             Rats • administration & dosage* • analysis •
             drug therapy* • etiology • metabolism},
   Abstract = {In view of the importance of insulin in hepatic cell
             proliferation and regeneration, disturbances might be
             expected in these processes in diabetics. The relative
             importnace of insulin replacement given intraportally rather
             than subcutaneously is discussed. Results are presented
             showing that even when normoglycaemia is achieved with
             peripheral insulin infusion using the 'artificial pancreas'
             there are still abnormalities in intermediary metabolism.
             The incidence of cirrhosis in diabetes is reviewed and it is
             concluded that the evidence is poor for an increase in
             diabetics. Finally it is shown that in the normal diabetic
             rat changes are observed after partial hepatectomy
             consistent with an increase in redox potential within the
             regenerating liver. Insulin treatment improves redox status
             but does not completely reverse the changes
             shown.},
   Language = {eng},
   Key = {fds174180}
}

@article{fds174272,
   Author = {GA Johnson and KG Alberti},
   Title = {The metabolic effects of sodium dichloroacetate in
             experimental hepatitis in the rat [proceedings]},
   Journal = {Biochemical Society transactions},
   Volume = {5},
   Number = {5},
   Pages = {1387-9},
   Year = {1977},
   ISSN = {0300-5127},
   Keywords = {Acetic Acids • Animals • Blood Glucose •
             Dichloroacetate • Fructose • Galactosamine •
             Hepatitis, Animal • Ketone Bodies • Lactates
             • Rats • blood • blood* • metabolism
             • pharmacology • pharmacology*},
   Language = {eng},
   Key = {fds174272}
}

@article{fds268747,
   Author = {JOHNSON, GA and OFOGHLUDHA, F},
   Title = {SPECTROMETRIC STUDIES OF WAVEFORM AND FILTRATION EFFECTS IN
             MAMMOGRAPHY},
   Journal = {Physics in Medicine and Biology},
   Volume = {22},
   Number = {3},
   Pages = {593-593},
   Year = {1977},
   ISSN = {0031-9155},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1977DH45600190&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {fds268747}
}

@article{fds174264,
   Author = {GA Johnson and E Harrington},
   Title = {An apparatus for the simultaneous demineralization of
             fifty-four specimens.},
   Journal = {Stain technology},
   Volume = {52},
   Number = {3},
   Pages = {127-9},
   Year = {1977},
   Month = {May},
   ISSN = {0038-9153},
   Keywords = {Evaluation Studies as Topic • Formic Acids •
             Histological Techniques • Specimen Handling •
             instrumentation*},
   Abstract = {An apparatus designed to demineralize 54 specimens
             simultaneously is described. A drum with built-in specimen
             holders rotates continuously through a bath of acid,
             allowing a free exchange of demineralizing fluid over the
             specimens. Individual specimens can be easily introduced or
             withdrawn from the apparatus without disturbing
             others.},
   Language = {eng},
   Key = {fds174264}
}

@article{fds174277,
   Author = {JD Peuler and GA Johnson},
   Title = {Simultaneous single isotope radioenzymatic assay of plasma
             norepinephrine, epinephrine and dopamine.},
   Journal = {Life sciences},
   Volume = {21},
   Number = {5},
   Pages = {625-36},
   Year = {1977},
   Month = {September},
   ISSN = {0024-3205},
   Keywords = {Catechol O-Methyltransferase • Dopamine •
             Epinephrine • Humans • Methods •
             Norepinephrine • blood* • cerebrospinal fluid
             • metabolism},
   Language = {eng},
   Key = {fds174277}
}

@article{fds174303,
   Author = {AJ Roberts and AP Niarchos and VA Subramanian and RM Abel and SD Herman and JE Sealey and DB Case and RP White and GA Johnson and JH Laragh and WA Gay
             Jr},
   Title = {Systemic hypertension associated with coronary artery bypass
             surgery. Predisposing factors, hemodynamic characteristics,
             humoral profile, and treatment.},
   Journal = {The Journal of thoracic and cardiovascular
             surgery},
   Volume = {74},
   Number = {6},
   Pages = {846-59},
   Year = {1977},
   Month = {December},
   ISSN = {0022-5223},
   Keywords = {Adult • Aged • Blood Pressure •
             Catecholamines • Coronary Artery Bypass • Coronary
             Vessels • Dopamine beta-Hydroxylase • Female
             • Hemodynamics • Humans • Hypertension •
             Male • Middle Aged • Nitroprusside • Renin
             • Vascular Resistance • adverse effects* •
             blood • drug therapy • etiology* • pathology
             • therapeutic use},
   Abstract = {Systemic hypertension occurs in more than one third of
             patients having coronary artery bypass graft (CABG)
             operations. This report describes our studies in 100
             consecutive patients undergoing CABG. We found that certain
             preoperative clinical, angiographic, and biochemical factors
             predispose to the development of perioperative hypertension.
             These included a well-documented history of hypertension, an
             elevated blood pressure the day prior to operation, greater
             than 50 percent obstruction of the left main coronary
             artery, and increased levels of dopamine beta hydroxylase
             (DBH). The hemodynamic pattern of perioperative hypertension
             was that of an increased systemic vascular resistance which
             was associated with increased levels of plasma
             catecholamines and plasma renin activity (PRA).
             Nitroprusside was shown to be effective in managing CABG
             hypertension, although other, more specific therapy may be
             preferable.},
   Language = {eng},
   Key = {fds174303}
}

@article{fds292759,
   Author = {Johnson, GA and Jr, ELM and O'Foghludha, F},
   Title = {Simple method of obtaining Si(Li) detector
             efficiency},
   Journal = {Nuclear Instruments and Methods},
   Volume = {151},
   Number = {1-2},
   Pages = {217-220},
   Year = {1978},
   ISSN = {0029-554X},
   Abstract = {The efficiency of a semi-conductor detector is measured by
             compairing its response with that of an NaI(Tl) detector of
             known efficiency when both are exposed to the same flux of
             gamma-excited fluorescent X-rays. The experimental procedure
             is outlined and corrections and limitations are discussed.
             The technique is an inexpensive and convenient way of
             determining semi-conductor efficiency up to about 100 keV
             using a single radionuclide source of modest activity and
             readily-available fluorescers. © 1978.},
   Key = {fds292759}
}

@article{fds268891,
   Author = {Johnson, GA and O'Foghludha, F},
   Title = {An experimental "trans-molybdenum" tube for
             mammography.},
   Journal = {Radiology},
   Volume = {127},
   Number = {2},
   Pages = {511-516},
   Year = {1978},
   Month = {May},
   ISSN = {0033-8419},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/644079},
   Keywords = {Fluorescence • Humans • Intubation •
             Mammography • Molybdenum • Radiation Dosage •
             instrumentation*},
   Abstract = {Possible mammographic advantages of "trans-molybdenum"
             anodes (atomic number greater than ZMo) are decreased dose
             because the fluorescent radiation is more penetrating, and
             increased useful output; contrast degradation is known to be
             tolerable. The output per mAs, the HVT in Al, and the
             penetration in Lucite were measured spectroscopically for an
             experimental Rh-anode tube and also for Mo- and W-anode
             mammographic tubes. The trans-molybdenum tube was shown to
             have output and dose advantages over Mo anodes, and output
             and contrast advantages over normal and selectively filtered
             W anodes. Possible applications in areas other than
             mammography are briefly discussed.},
   Doi = {10.1148/127.2.511},
   Key = {fds268891}
}

@article{fds174098,
   Author = {GA Johnson and JM Gren and R Kupiecki},
   Title = {Radioenzymatic assay of DOPA (3,4-dihydroxyphenylalanine).},
   Journal = {Clinical chemistry},
   Volume = {24},
   Number = {11},
   Pages = {1927-30},
   Year = {1978},
   Month = {November},
   ISSN = {0009-9147},
   Keywords = {Adult • Animals • Catechol O-Methyltransferase
             • Dihydroxyphenylalanine • Dopa Decarboxylase
             • Female • Humans • Male • analysis*
             • blood},
   Abstract = {We modified the single-isotope radioenzymatic assay for
             catecholamines [Life Sci. 21, 625 (1977)] to assay 3,
             4-dihydroxyphenylalanine (DOPA). DOPA decarboxylase is used
             to convert DOPA to dopamine, which concurrently is converted
             to [3H]-3-O-methyldopamine in the presence of
             catechol-O-methyltransferase and [methyl-3H]-S-adenosylmethionine
             and assayed radioenzymatically. For assay of plasma DOPA, 50
             microliter of untreated plasma is added directly into the
             incubation mixture. A duplicate mixture containing an
             internal standard requires a second 50-microliter aliquot of
             plasma. Because the assay measures both DOPA and endogenous
             dopamine, two additonal aliquots of plasma must be assayed
             for dopamine in the absence of the decarboxylase by the
             differential assay; DOPA is estimated by difference. The
             assay is sensitive to 25 pg (500 ng/liter of plasma).
             Analysis of DOPA (DOPA plus dopamine) and the concurrent
             differential assay of catecholamines in at least 10 samples
             can be done in a single working day. Plasma DOPA
             concentrations for 42 normotensive adults were 1430 +/- 19
             ng/liter (mean +/- SEM). In contrast, do-pamine
             concentrations for these same subjects averaged 23 +/- 20
             ng/liter. Values for the 24 women subjects (15 10 +/- 62
             ng/liter) significantly (P = 0.04) exceeded those for the
             men (1320 +/- 75 ng/liter).},
   Language = {eng},
   Key = {fds174098}
}

@article{fds268746,
   Author = {HEDLUND, L and JONES, D and EFFMANN, E and JOHNSON, GA and BATES, W and WOLFE, W and PUTMAN, C},
   Title = {COMPUTERIZED TOMOGRAPHIC STUDY OF THE DOG LUNG DURING
             HEMORRHAGIC-SHOCK},
   Journal = {Investigative Radiology},
   Volume = {14},
   Number = {5},
   Pages = {369-369},
   Year = {1979},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1979HQ94500028&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {fds268746}
}

@article{fds174246,
   Author = {D Robertson and GA Johnson and RM Robertson and AS Nies and DG Shand and JA
             Oates},
   Title = {Comparative assessment of stimuli that release neuronal and
             adrenomedullary catecholamines in man.},
   Journal = {Circulation},
   Volume = {59},
   Number = {4},
   Pages = {637-43},
   Year = {1979},
   Month = {April},
   ISSN = {0009-7322},
   Keywords = {Adolescent • Adrenal Medulla • Adult • Blood
             Specimen Collection • Caffeine • Catecholamines
             • Epinephrine • Female • Humans •
             Isometric Contraction • Male • Middle Aged •
             Neurons • Norepinephrine • Physical Stimulation
             • Posture • Pressoreceptors • Valsalva
             Maneuver • blood • pharmacology •
             physiology*},
   Abstract = {We assessed the release of neuronal and adrenomedullary
             catecholamines in response to various stimuli of the
             sympathetic nervous system in normal subjects. Plasma
             catecholamines and their urinary metabolites,
             normetanephrine and metanephrine, were measured. Sodium
             restriction increased supine plasma norepinephrine by 37%
             and ambulatory plasma norepinephrine by 22%, with urinary
             normetanephrine excretion increased 29%. The sodium
             restriction did not elevate plasma epinephrine or urinary
             metanephrine. The most potent stimuli of norepinephrine were
             treadmill exercise, orthostasis, caffeine, the cold pressor
             test, sodium restriction and handgrip exercise, in
             descending order. Plasma epinephrine was increased by
             caffeine, treadmill exercise, the cold pressor test,
             handgrip exercise and the Valsalva maneuver, in that order.
             Syncope resulted in profound changes in plasma epinephrine
             but only modest changes in plasma norepinephrine. We
             conclude that in man, there is frequent dissociation between
             the effects of different stimuli on neuronal and
             adrenomedullary catecholamine release.},
   Language = {eng},
   Key = {fds174246}
}

@article{fds174104,
   Author = {L Helson and GA Johnson and R Smith},
   Title = {DOPA metabolism in neuroblastoma.},
   Journal = {Medical and pediatric oncology},
   Volume = {8},
   Number = {4},
   Pages = {317-22},
   Year = {1980},
   ISSN = {0098-1532},
   Keywords = {Adolescent • Bone Neoplasms • Brain Neoplasms
             • Child • Dihydroxyphenylalanine • False
             Negative Reactions • Female • Humans •
             Leukemia • Lymphoma • Neoplasm Recurrence, Local
             • Neuroblastoma • Time Factors •
             Vanilmandelic Acid • blood • cerebrospinal fluid
             • metabolism • metabolism* •
             urine},
   Abstract = {Blood plasma samples from 60 neuroblastoma patients prior
             to, during, and following treatment were studied for their
             content of circulating DOPA using a radioenzymatic assay.
             Normal values were established from children who were
             tumor-free or had other nonneurogenic tumors. The highest
             plasma DOPA concentration in tumor-free or nonneuroblastoma
             controls was 5.3 ng/ml with a mean of 2.15 ng/ml. Most
             neuroblastoma patients (28/31) with active disease had DOPA
             values above this level. Only one out of 30 "successfully"
             treated patients without evidence of disease was encountered
             with an abnormally high level. In treated patients, elevated
             values forewarned of impending clinical recurrence or
             persistent tumor. Cerebrospinal fluid DOPA levels in one
             patient with cerebral neuroblastoma were extraordinarily
             high and suggests that this assay may prove useful to
             distinguish neuroblastoma from other central neuroectodermal
             or metastatic tumors. Plasma DOPA appears to be a reliable
             predictive and diagnostic test for neuroblastoma.},
   Language = {eng},
   Key = {fds174104}
}

@booklet{Johnson80e,
   Author = {JOHNSON, GA and RAVIN, CE},
   Title = {SCATTERED RADIATION FROM THE FILM HOLDER IN CHEST
             RADIOGRAPHY},
   Journal = {AJR. American journal of roentgenology},
   Volume = {134},
   Number = {1},
   Pages = {201-201},
   Year = {1980},
   ISSN = {0361-803X},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1980HZ88000054&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Johnson80e}
}

@booklet{Johnson80b,
   Author = {JOHNSON, GA and HOLT, DC and EFFMANN, EL},
   Title = {PRACTICAL GUIDELINES FOR SPECIMEN RADIOGRAPHY},
   Journal = {Investigative Radiology},
   Volume = {15},
   Number = {5},
   Pages = {377-377},
   Year = {1980},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1980KK17000009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Johnson80b}
}

@booklet{Johnson80d,
   Author = {JOHNSON, GA and FOGHLUDA, F},
   Title = {AN INVESTIGATION OF TRANSMOLYBDENUM FLUORESCENT ANODES FOR
             MAMMOGRAPHY},
   Journal = {AJR. American journal of roentgenology},
   Volume = {134},
   Number = {4},
   Pages = {855-855},
   Year = {1980},
   ISSN = {0361-803X},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1980JM11100062&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Johnson80d}
}

@booklet{Thompson80a,
   Author = {THOMPSON, WM and AMBERG, JR and LOWTHER, DT and SHAW, M and BATES, M and JOHNSON, GA},
   Title = {GALLBLADDER DENSITY AND IODINE CONCENTRATION IN HUMANS
             DURING ORAL CHOLECYSTOGRAPHY - A COMPARISON OF IOPANOIC ACID
             AND IOPRONIC ACID},
   Journal = {Abdominal Imaging},
   Volume = {5},
   Number = {1},
   Pages = {83-83},
   Year = {1980},
   ISSN = {0364-2356},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1980JN17700030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Thompson80a}
}

@booklet{Thompson80,
   Author = {THOMPSON, WM and AMBERG, JR and SHAW, M and BATES, M and HEDLUNG, L and JOHNSON, GA},
   Title = {IODINE CONCENTRATION AND RADIOGRAPHIC DENSITY DURING ORAL
             CHOLECYSTOGRAPHY},
   Journal = {Investigative Radiology},
   Volume = {15},
   Number = {5},
   Pages = {397-397},
   Year = {1980},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1980KK17000048&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198009000-00049},
   Key = {Thompson80}
}

@article{fds326004,
   Author = {Wolbarsht, ML and O'Foghludha, FA and Sliney, DH and Guy, AW and Jr,
             AAS and Johnson, GA},
   Title = {ELECTROMAGNETIC EMISSION FROM VISUAL DISPLAY UNITS: A
             NON-HAZARD.},
   Journal = {Proceedings of the Society of Photo-Optical Instrumentation
             Engineers},
   Volume = {229},
   Pages = {187-195},
   Year = {1980},
   url = {http://dx.doi.org/10.1117/12.958802},
   Abstract = {An analysis of the electromagnetic emissions of an IBM Model
             3277 visual display unit showed no hazardous levels in any
             portion of the spectrum. The actual level of emission was
             measured throughout the spectrum from low frequency radio
             waves through x-radiations, extending from 10 KHz through 10
             GHz, then 0. 2 to 10 mu m, and from 5 to over 40 kev. In
             many parts of the spectrum, the level of emission was below
             the sensitivity of available instrumentation. In the radio
             frequency range, including the microwave region,
             measurements were also made on black and white and color TV
             sets for the purpose of comparison.},
   Doi = {10.1117/12.958802},
   Key = {fds326004}
}

@booklet{Green80,
   Author = {D. J. Green and G. A. Johnson and S. T. Hutchison},
   Title = {Hot-pressing sodium beta-alumina using solution spray-dried
             and freeze-dried powders},
   Journal = {Journal Of The Canadian Ceramic Society},
   Volume = {49},
   Pages = {7 -- 12},
   Year = {1980},
   Key = {Green80}
}

@booklet{Stafford80,
   Author = {M. L. Stafford and K. F. Guin and G. A. Johnson and L. A.
             Sanders and S. L. Rockey},
   Title = {Analysis of 1,4-dioxane in ethoxylated surfactants},
   Journal = {Journal Of The Society Of Cosmetic Chemists},
   Volume = {31},
   Number = {6},
   Pages = {281 -- 287},
   Year = {1980},
   Key = {Stafford80}
}

@booklet{Johnson80c,
   Author = {G. A. Johnson and C. A. Baker and R. T. Smith},
   Title = {Radioenzymatic assay of sulfate conjugates of catecholamines
             and dopa in plasma},
   Journal = {Life Sciences},
   Volume = {26},
   Number = {19},
   Pages = {1591 -- 1598},
   Year = {1980},
   Key = {Johnson80c}
}

@booklet{Helson80,
   Author = {L. Helson and G. A. Johnson and R. Smith},
   Title = {Dopa metabolism in neuro-blastoma},
   Journal = {Medical And Pediatric Oncology},
   Volume = {8},
   Number = {4},
   Pages = {317 -- 322},
   Year = {1980},
   Key = {Helson80}
}

@booklet{Helson80a,
   Author = {L. Helson and A. Majeranowski and C. Helson and M. Schwartz and G. A. Johnson and J. Nisselbaum},
   Title = {Dopa decarboxylase (ddc) and tryptophan decarboxylase(tdc)
             in neuroectodermal tumors - 2 separate enzymes},
   Journal = {Proceedings Of The American Association For Cancer
             Research},
   Volume = {21},
   Number = {MAR},
   Pages = {322 -- 322},
   Year = {1980},
   Key = {Helson80a}
}

@booklet{Johnson80a,
   Author = {G. A. Johnson and R. M. Kupiecki and C. A.
             Baker},
   Title = {Single isotope derivative (radioenzymatic) methods in the
             measurement of catecholamines},
   Journal = {Metabolism-clinical And Experimental},
   Volume = {29},
   Number = {11},
   Pages = {1106 -- 1113},
   Year = {1980},
   Key = {Johnson80a}
}

@booklet{Johnson80,
   Author = {Johnson, GA and O'Foghludha, F},
   Title = {Simulation of mammographic x-ray spectra.},
   Journal = {Medical physics},
   Volume = {7},
   Number = {3},
   Pages = {189-195},
   Year = {1980},
   Month = {May},
   ISSN = {0094-2405},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/7393143},
   Abstract = {Attempts to simulate Mo-anode spectra for film mammography
             by using Mo filters with W-anode tubes have been reported by
             several workers, and others have generated W-like continua
             for xeromammographic purposes by heavy Al filtration of
             Mo-anode tubes. In the present work the success of these
             simulations was tested by Si(Li) spectrometric methods that
             measured the spectral shapes and the exposure levels.
             Comparisons of Mo-anode/Al-filter with W-anode/Al-filter
             combinations were made, and also of W-anode/M-filter with
             Mo-anode/Mo-folter combinations. In certain circumstance the
             spectral shape is moderately well simulated but in all cases
             the useful output is less in the simulations than in the
             original spectra. The general conclusion is that simulation
             is always less attractive than direct use of the desired
             anode.},
   Doi = {10.1118/1.594684},
   Key = {Johnson80}
}

@article{fds174262,
   Author = {GA Johnson and CA Baker and RT Smith},
   Title = {Radioenzymatic assay of sulfate conjugates of catecholamines
             and DOPA in plasma.},
   Journal = {Life sciences},
   Volume = {26},
   Number = {19},
   Pages = {1591-8},
   Year = {1980},
   Month = {May},
   ISSN = {0024-3205},
   Keywords = {Adolescent • Adult • Arylsulfatases •
             Catecholamines • Child • Child, Preschool •
             Dihydroxyphenylalanine • Dopamine • Epinephrine
             • Female • Humans • Infant • Male •
             Norepinephrine • Posture • Radioimmunoassay •
             Sulfuric Acid Esters • blood •
             blood*},
   Language = {eng},
   Key = {fds174262}
}

@article{fds174243,
   Author = {GA Johnson and RM Kupiecki and CA Baker},
   Title = {Single isotope derivative (radioenzymatic) methods in the
             measurement of catecholamines.},
   Journal = {Metabolism: clinical and experimental},
   Volume = {29},
   Number = {11 Suppl 1},
   Pages = {1106-13},
   Year = {1980},
   Month = {November},
   ISSN = {0026-0495},
   Keywords = {Catechol O-Methyltransferase* • Catecholamines •
             Chemical Phenomena • Chemistry • Chromatography,
             Thin Layer • Dopa Decarboxylase • Humans •
             Methods • Phenylethanolamine N-Methyltransferase*
             • S-Adenosylmethionine* • Tritium • analysis*
             • cerebrospinal fluid},
   Language = {eng},
   Key = {fds174243}
}

@booklet{Johnson81e,
   Author = {JOHNSON, GA and FORD, KK and HEINZ, R},
   Title = {DIGITAL RADIOGRAPHY USING THE QUANTEX DS-20},
   Journal = {AJR. American journal of roentgenology},
   Volume = {136},
   Number = {6},
   Pages = {1274-1274},
   Year = {1981},
   ISSN = {0361-803X},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1981LU08900069&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Johnson81e}
}

@booklet{Johnson81a,
   Author = {Johnson, GA and Korobkin, M and Heinz, ER},
   Title = {EVALUATION OF MULTIPLANAR IMAGING CAPABILITIES OF FOUR
             CURRENT COMPUTED TOMOGRAPHY (CT) SCANNERS.},
   Journal = {Proceedings of SPIE - The International Society for Optical
             Engineering},
   Volume = {273},
   Pages = {318-325},
   Year = {1981},
   Key = {Johnson81a}
}

@booklet{Halvorsen81,
   Author = {HALVORSEN, RA and WOODFIELD, S and ALLEN, SM and HEDLUNG, LW and JOHNSON, GA and THOMPSON, WM},
   Title = {AN EVALUATION OF CONTRAST AGENTS FOR CT OF THE HEPATOBILIARY
             SYSTEM},
   Journal = {Investigative Radiology},
   Volume = {16},
   Number = {5},
   Pages = {387-387},
   Year = {1981},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1981MK56200053&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198109000-00053},
   Key = {Halvorsen81}
}

@booklet{Korobkin81,
   Author = {KOROBKIN, M and JOHNSON, GA and BREIMAN, RS},
   Title = {METHODOLOGIC CONSIDERATIONS IN MULTIPLANAR REFORMATTING OF
             TRANSAXIAL CT-IMAGES},
   Journal = {Investigative Radiology},
   Volume = {16},
   Number = {5},
   Pages = {374-374},
   Year = {1981},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1981MK56200027&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198109000-00027},
   Key = {Korobkin81}
}

@booklet{Nelson81,
   Author = {NELSON, CE and JOHNSON, GA and BENTEL, G},
   Title = {MULTI-PLANAR RECONSTRUCTION - APPLICATIONS IN RADIATION
             ONCOLOGY TREATMENT PLANNING},
   Journal = {Investigative Radiology},
   Volume = {16},
   Number = {5},
   Pages = {417-417},
   Year = {1981},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1981MK56200113&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198109000-00113},
   Key = {Nelson81}
}

@booklet{Johnson81d,
   Author = {JOHNSON, GA and NELSON, CE and OFOGHLUDHA, F},
   Title = {IMAGING LIMITS IN DIGITAL RADIOGRAPHY},
   Journal = {Investigative Radiology},
   Volume = {16},
   Number = {5},
   Pages = {377-377},
   Year = {1981},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1981MK56200033&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198109000-00033},
   Key = {Johnson81d}
}

@booklet{Johnson81,
   Author = {JOHNSON, GA and KOROBKIN, M and HEINZ, R},
   Title = {AN EVALUATION OF MULTIPLANAR IMAGING CAPABILITIES OF 4
             CURRENT CT SCANNERS},
   Journal = {AJR. American journal of roentgenology},
   Volume = {136},
   Number = {6},
   Pages = {1279-1279},
   Year = {1981},
   ISSN = {0361-803X},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1981LU08900097&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Johnson81}
}

@booklet{Johnson81,
   Author = {Johnson, GA and Ford, K and Heinz, R},
   Title = {DIGITAL RADIOGRAPHY USING THE QUANTEX DS-20.},
   Journal = {Proceedings of SPIE - The International Society for Optical
             Engineering},
   Volume = {273},
   Pages = {114-119},
   Year = {1981},
   Key = {Johnson81}
}

@booklet{Bristow81,
   Author = {M. R. Bristow and W. A. Minobe and M. E. Billingham and J.
             B. Marmor and G. A. Johnson and B. M. Ishimoto and W. S.
             Sageman and J. R. Daniels},
   Title = {Anthracycline-associated cardiac and renal damage in rabbits
             - evidence for mediation by vasoactive substances},
   Journal = {Laboratory Investigation},
   Volume = {45},
   Number = {2},
   Pages = {157 -- 168},
   Year = {1981},
   Key = {Bristow81}
}

@booklet{Johnson81b,
   Author = {G. A. Johnson and J. J. Mcnamara},
   Title = {Organ ischemia after hemorrhagic-shock},
   Journal = {Surgical Forum},
   Volume = {32},
   Pages = {24 -- 26},
   Year = {1981},
   Key = {Johnson81b}
}

@booklet{Johnson81c,
   Author = {G. A. Johnson and J. J. Mcnamara},
   Title = {Thromboxane-a2 - a vital mediator in the acute response to
             hemorrhage},
   Journal = {Circulation},
   Volume = {64},
   Number = {4},
   Pages = {290 -- 290},
   Year = {1981},
   Key = {Johnson81c}
}

@booklet{Johnston81,
   Author = {D. G. Johnston and G. A. Johnson and H. Millwardsadler},
   Title = {Insulin and liver-regeneration after partial-hepatectomy
             (ph) in normal and diabetic rats},
   Journal = {Diabetologia},
   Volume = {21},
   Number = {3},
   Pages = {288 -- 288},
   Year = {1981},
   Key = {Johnston81}
}

@booklet{Baker81,
   Author = {C. A. Baker and G. A. Johnson},
   Title = {Radioenzymatic assay of dihydroxyphenylglycol (dopeg) and
             dihydroxyphenylethanol (dopet) in plasma and
             cerebrospinal-fluid},
   Journal = {Life Sciences},
   Volume = {29},
   Number = {2},
   Pages = {165 -- 172},
   Year = {1981},
   Key = {Baker81}
}

@booklet{Robinson81,
   Author = {D. S. Robinson and G. A. Johnson and J. Corcella and A. Nies and D. Howard and T. B. Cooper},
   Title = {Plasma 3,4-dihydroxyphenylglycol, catecholamines, and
             anti-depressant drug levels during treatment of
             depression},
   Journal = {Clinical Pharmacology \& Therapeutics},
   Volume = {29},
   Number = {2},
   Pages = {277 -- 277},
   Year = {1981},
   Key = {Robinson81}
}

@booklet{Johnson81a,
   Author = {Johnson, GA and Ravin, CE},
   Title = {Effect of vertical cassette holder design and construction
             on scatter-to-primary radiation ratios.},
   Journal = {Radiology},
   Volume = {138},
   Number = {2},
   Pages = {461-464},
   Year = {1981},
   Month = {February},
   ISSN = {0033-8419},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/7455131},
   Abstract = {This paper analyzes the contribution to scattered radiation
             at the film plane by individual components of a conventional
             wall-mounted cassette holder. With grid technique, scatter
             from the front panel of the cassette holder is effectively
             reduced, but considerable scatter reaches the film plane
             from the automatic exposure control pickup interposed
             between the grid and the film cassette. With air-gap
             technique (grid removed), the front panel of the cassette
             holder and the automatic exposure control pickup contribute
             equally to increased scattered radiation at the film plane.
             The contribution to the total scatter from the air-gap
             positioning plate is less significant.},
   Doi = {10.1148/radiology.138.2.7455131},
   Key = {Johnson81a}
}

@article{fds132769,
   Author = {GA Johnson and CE Ravin},
   Title = {Effect of vertical cassette holder design and construction
             on scatter-to-primary radiation ratios.},
   Journal = {Radiology, UNITED STATES},
   Volume = {138},
   Number = {2},
   Pages = {461-4},
   Year = {1981},
   Month = {February},
   ISSN = {0033-8419},
   Keywords = {Humans • Radiography • Scattering, Radiation*
             • Technology, Radiologic • instrumentation*},
   Abstract = {This paper analyzes the contribution to scattered radiation
             at the film plane by individual components of a conventional
             wall-mounted cassette holder. With grid technique, scatter
             from the front panel of the cassette holder is effectively
             reduced, but considerable scatter reaches the film plane
             from the automatic exposure control pickup interposed
             between the grid and the film cassette. With air-gap
             technique (grid removed), the front panel of the cassette
             holder and the automatic exposure control pickup contribute
             equally to increased scattered radiation at the film plane.
             The contribution to the total scatter from the air-gap
             positioning plate is less significant.},
   Key = {fds132769}
}

@booklet{Ofoghludha81,
   Author = {O'Foghludha, F and Johnson, GA},
   Title = {Voltage waveform effects on output and penetration of W- and
             Mo-anode mammographic tubes.},
   Journal = {Physics in Medicine and Biology},
   Volume = {26},
   Number = {2},
   Pages = {291-303},
   Year = {1981},
   Month = {March},
   ISSN = {0031-9155},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/7220605},
   Abstract = {The output and half-value thickness (HVT) for arbitrary
             voltage waveforms can be calculated if the variation of both
             quantities with voltage is known under constant-potential
             (ripple-free) conditions. An apparatus to study this
             variation is described. It permits measurements of output
             and HVT with a Si(Li) spectrometer under conditions
             equivalent to constant-potential operation; it uses
             mechanical or electronic gating to limit observations to
             constant-potential operation; it uses mechanical or
             electronic gating to limit observations to short periods
             near the peaks of a sinusoidal waveform. For W anodes both
             HVT and output are found to follow simple power laws, while
             polynomial functions of voltage are needed for Mo anodes.
             Calculations based on these data agree well with experiments
             in which various ripples are simulated by altering the
             gating interval. For Mo anodes, the output increases as the
             ripple decreases, but the HVT changes very little. For W
             anodes both quantities decrease when the ripple increases.
             The implications in mammography are briefly
             discussed.},
   Key = {Ofoghludha81}
}

@article{fds132887,
   Author = {F O'Foghludha and GA Johnson},
   Title = {Voltage waveform effects on output and penetration of W- and
             Mo-anode mammographic tubes.},
   Journal = {Physics in medicine and biology, ENGLAND},
   Volume = {26},
   Number = {2},
   Pages = {291-303},
   Year = {1981},
   Month = {March},
   ISSN = {0031-9155},
   Keywords = {Electrodes • Female • Humans • Mammography
             • Molybdenum • Tungsten • instrumentation
             • methods*},
   Abstract = {The output and half-value thickness (HVT) for arbitrary
             voltage waveforms can be calculated if the variation of both
             quantities with voltage is known under constant-potential
             (ripple-free) conditions. An apparatus to study this
             variation is described. It permits measurements of output
             and HVT with a Si(Li) spectrometer under conditions
             equivalent to constant-potential operation; it uses
             mechanical or electronic gating to limit observations to
             constant-potential operation; it uses mechanical or
             electronic gating to limit observations to short periods
             near the peaks of a sinusoidal waveform. For W anodes both
             HVT and output are found to follow simple power laws, while
             polynomial functions of voltage are needed for Mo anodes.
             Calculations based on these data agree well with experiments
             in which various ripples are simulated by altering the
             gating interval. For Mo anodes, the output increases as the
             ripple decreases, but the HVT changes very little. For W
             anodes both quantities decrease when the ripple increases.
             The implications in mammography are briefly
             discussed.},
   Key = {fds132887}
}

@article{fds174099,
   Author = {AH Fishel and GA Johnson},
   Title = {The three-way conference -- nursing student, nursing
             supervisor and nursing educator.},
   Journal = {The Journal of nursing education},
   Volume = {20},
   Number = {6},
   Pages = {18-23},
   Year = {1981},
   Month = {June},
   ISSN = {0148-4834},
   Keywords = {Communication* • Education, Nursing, Baccalaureate*
             • Humans • Interpersonal Relations • Nursing,
             Supervisory* • Psychiatric Nursing • Students,
             Nursing* • Teaching* • education},
   Language = {eng},
   Key = {fds174099}
}

@article{fds174229,
   Author = {GA Johnson},
   Title = {Settlement Patterns and Their Meaning.},
   Journal = {Science (New York, N.Y.)},
   Volume = {213},
   Number = {4503},
   Pages = {126-127},
   Year = {1981},
   Month = {July},
   ISSN = {1095-9203},
   url = {http://dx.doi.org/10.1126/science.213.4503.126},
   Language = {ENG},
   Doi = {10.1126/science.213.4503.126},
   Key = {fds174229}
}

@article{fds174132,
   Author = {CA Baker and GA Johnson},
   Title = {Radioenzymatic assay of dihydroxyphenylglycol (DOPEG) and
             dihydroxyphenylethanol (DOPET) in plasma and cerebrospinal
             fluid.},
   Journal = {Life sciences},
   Volume = {29},
   Number = {2},
   Pages = {165-72},
   Year = {1981},
   Month = {July},
   ISSN = {0024-3205},
   Keywords = {Adult • Aged • Animals • Cats • Dogs
             • Ethanol • Female • Glycols • Humans
             • Infant • Male • Methoxyhydroxyphenylglycol
             • Middle Aged • Phenylethyl Alcohol •
             Radioisotope Dilution Technique • Rats •
             S-Adenosylmethionine • Tritium • analogs &
             derivatives • analogs & derivatives* • blood
             • blood* • cerebrospinal fluid},
   Language = {eng},
   Key = {fds174132}
}

@article{fds174100,
   Author = {MR Bristow and WA Minobe and ME Billingham and JB Marmor and GA Johnson and BM Ishimoto and WS Sageman, JR Daniels},
   Title = {Anthracycline-associated cardiac and renal damage in
             rabbits. Evidence for mediation by vasoactive
             substances.},
   Journal = {Laboratory investigation; a journal of technical methods and
             pathology},
   Volume = {45},
   Number = {2},
   Pages = {157-68},
   Year = {1981},
   Month = {August},
   ISSN = {0023-6837},
   Keywords = {Animals • Arteries • Cardiomyopathies •
             Catecholamines • Doxorubicin • Female •
             Histamine Antagonists • Histamine Release • Kidney
             Diseases • Myocardium • Rabbits •
             Vasoconstrictor Agents • Vasodilator Agents •
             adverse effects* • blood • chemically induced*
             • metabolism • pharmacology •
             pharmacology*},
   Abstract = {We tested the hypothesis that anthracycline-induced cardiac
             and renal damage is mediated by vasoactive substances. A
             1-minute exposure to 5 micrograms per ml. of doxorubicin
             (DXR, Adriamycin) produced cardiac histamine release in
             isolated rabbit hearts. Under conditions in which histamine
             uptake and metabolism were impaired, the administration of
             DXR, 2 mg. per kg., over 1 minute was associated with
             elevations in arterial histamine and catecholamines. The
             chronic weekly administration of DXR produced severe cardiac
             and renal damage. The administration of combined histaminic
             and adrenergic blockade with diphenhydramine, cimetidine,
             phentolamine, and propranolol (DCPP) pre- and immediately
             post-DXR resulted in near total protection against
             DXR-mediated cardiac damage and prevented the majority of
             the renal lesions. The combined administration of
             diphenhydramine, cimetidine, phentolamine, and propranolol
             did not appear to be acting by mechanisms other than
             blockade of vasoactive amine receptors as cardiac uptake of
             DXR and the DXR antitumor response were not altered by
             diphenhydramine, cimetidine, phentolamine, and propranolol.
             This study demonstrates that anthracycline-associated
             cardiac and renal toxicity may be mediated by vasoactive
             substances and that anthracycline cardiomyopathy is
             potentially preventable.},
   Language = {eng},
   Key = {fds174100}
}

@booklet{Hedlund81,
   Author = {Hedlund, LW and Jones, DP and Effmann, EL and Johnson, GA and Bates, WM and Beck, JW and Wolfe, W and Putman, CE},
   Title = {A computed tomographic study of the dog lung during
             hemorrhagic shock and after resuscitation.},
   Journal = {Investigative Radiology},
   Volume = {16},
   Number = {6},
   Pages = {466-472},
   Year = {1981},
   Month = {November},
   ISSN = {0020-9996},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/7319752},
   Abstract = {A shock model was used to explore the capability of computed
             tomography (CT) to detect changes in lung density during
             hypovolemia and after resuscitation. The same level of the
             lower thorax was scanned repeatedly during base-line, shock
             (aortic pressure 60 mmHg), and after resuscitation with shed
             blood. The average baseline CT number (+/- SEM) for 5 areas
             of interest for four prone dogs was -754 +/- 16 (air =
             -1000, water = 0). This decreased 7.4% to -810 +/- 15 (P
             less than .05) during shock. After resuscitation CT density
             was -773 +/- 17 or 2.5% less than baseline (P greater than
             .1). A dorsal to ventral gradient of increasing CT density
             during baseline was maintained in all five areas during
             shock and post-resuscitation. From baseline to shock there
             were also significant changes in heart rate, mean aortic
             pressure, cardiac output, and vascular volume. Extravascular
             lung volume after resuscitation was equal to baseline
             volume. We conclude that CT is sufficiently sensitive to
             detect rapid physiological changes leading to increased or
             decreased lung density.},
   Key = {Hedlund81}
}

@booklet{Silverman82b,
   Author = {SILVERMAN, PM and JOHNSON, GA and KOROBKIN, M and THOMPSON,
             WM},
   Title = {HIGH-RESOLUTION MULTIPLANAR CT IMAGES OF THE
             LARYNX},
   Journal = {Investigative Radiology},
   Volume = {17},
   Number = {4},
   Pages = {S34-S34},
   Year = {1982},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1982PA96700153&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198207000-00161},
   Key = {Silverman82b}
}

@booklet{Johnson82f,
   Author = {JOHNSON, GA},
   Title = {A PRACTICAL APPROACH TO QUALITY ASSURANCE IN
             CT},
   Journal = {AJR. American journal of roentgenology},
   Volume = {139},
   Number = {2},
   Pages = {427-427},
   Year = {1982},
   ISSN = {0361-803X},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1982NY43600075&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Johnson82f}
}

@booklet{Halvorsen82,
   Author = {HALVORSEN, RA and WOODFIELD, S and HEDLUND, L and JOHNSON, GA and THOMPSON, WM},
   Title = {CONTRAST ENHANCEMENT OF THE HEPATOBILIARY SYSTEM DURING CT -
             A COMPARISON OF BILIARY AND VASCULAR AGENTS},
   Journal = {Investigative Radiology},
   Volume = {17},
   Number = {4},
   Pages = {S27-S27},
   Year = {1982},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1982PA96700126&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198207000-00134},
   Key = {Halvorsen82}
}

@booklet{Johnson82,
   Author = {Johnson, GA},
   Title = {PRACTICAL APPROACH TO QUALITY ASSURANCE IN COMPUTED
             TOMOGRAPHY.},
   Journal = {Proceedings of SPIE - The International Society for Optical
             Engineering},
   Volume = {347},
   Pages = {148-154},
   Year = {1982},
   Key = {Johnson82}
}

@booklet{Ford82a,
   Author = {Ford, KK and Heinz, ER and Johnson, GA and Drayer, BP and Dubois,
             PJ},
   Title = {Low-cost digital subtraction},
   Journal = {American Journal Of Neuroradiology},
   Volume = {3},
   Number = {1},
   Pages = {99-99},
   Year = {1982},
   Key = {Ford82a}
}

@booklet{Thompson82,
   Author = {W. M. Thompson and W. C. Meyers and M. Shaw and M. Bates and G. A. Johnson and L. W. Hedlund},
   Title = {Gallbladder density and iodine concentration in humans
             during oral cholecystography - a comparison of iopanoic acid
             and iopronic acid},
   Journal = {Investigative Radiology},
   Volume = {17},
   Number = {6},
   Pages = {621 -- 628},
   Year = {1982},
   Key = {Thompson82}
}

@booklet{Johnson82b,
   Author = {G. A. Johnson},
   Title = {Synthesized signal generator sets phase-noise
             standard},
   Journal = {Microwaves \& Rf},
   Volume = {21},
   Number = {12},
   Pages = {110 -- 111},
   Year = {1982},
   Key = {Johnson82b}
}

@booklet{Johnson82d,
   Author = {G. A. Johnson and K. J. Barsuhn and J. M.
             Mccall},
   Title = {Sulfation of minoxidil by liver sulfotransferase},
   Journal = {Biochemical Pharmacology},
   Volume = {31},
   Number = {18},
   Pages = {2949 -- 2954},
   Year = {1982},
   Key = {Johnson82d}
}

@booklet{Silverman82a,
   Author = {P. M. Silverman and M. Korobkin and W. M. Thompson and G. A.
             Johnson and T. B. Cole and S. R. Fisher},
   Title = {Work in progress - high-resolution, thin-section
             computed-tomography of the larynx},
   Journal = {Radiology},
   Volume = {145},
   Number = {3},
   Pages = {723 -- 725},
   Year = {1982},
   Key = {Silverman82a}
}

@booklet{Johnson82a,
   Author = {G. A. Johnson},
   Title = {A generalization of n-matrices},
   Journal = {Linear Algebra And Its Applications},
   Volume = {48},
   Number = {DEC},
   Pages = {201 -- 217},
   Year = {1982},
   Key = {Johnson82a}
}

@article{fds174278,
   Author = {GA Johnson},
   Title = {Political Developments in Prehistory.},
   Journal = {Science (New York, N.Y.)},
   Volume = {216},
   Number = {4548},
   Pages = {867-869},
   Year = {1982},
   Month = {May},
   ISSN = {1095-9203},
   url = {http://dx.doi.org/10.1126/science.216.4548.867},
   Language = {ENG},
   Doi = {10.1126/science.216.4548.867},
   Key = {fds174278}
}

@booklet{Godwin82,
   Author = {Godwin, JD and Speckman, JM and Fram, EK and Johnson, GA and Putman, CE and Korobkin, M and Breiman, RS},
   Title = {Distinguishing benign from malignant pulmonary nodules by
             computed tomography.},
   Journal = {Radiology},
   Volume = {144},
   Number = {2},
   Pages = {349-351},
   Year = {1982},
   Month = {July},
   ISSN = {0033-8419},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/7089288},
   Abstract = {Investigators have been able to distinguish benign pulmonary
             nodules from malignant ones in about two-thirds of the cases
             studied by detecting high computed tomography (CT) numbers
             (attributed to microscopic calcifications) within many
             benign nodules. This paper reports a similar analysis on a
             series of 22 benign and 14 malignant pulmonary nodules.
             Although about one-third of the benign nodules gave high CT
             numbers, all but one of the nodules diagnosed as benign by
             CT could also be diagnosed by detection of calcification on
             plain radiographs or conventional tomograms.},
   Doi = {10.1148/radiology.144.2.7089288},
   Key = {Godwin82}
}

@booklet{Ford82,
   Author = {Ford, KK and Heinz, ER and Johnson, GA and Drayer, BD and Dubois,
             PJ},
   Title = {Low-cost digital subtraction angiography.},
   Journal = {American Journal of Neuroradiology},
   Volume = {3},
   Number = {4},
   Pages = {448-451},
   Year = {1982},
   Month = {July},
   ISSN = {0195-6108},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/6810680},
   Key = {Ford82}
}

@article{fds132824,
   Author = {JD Godwin and JM Speckman and EK Fram and GA Johnson and CE Putman and M
             Korobkin, RS Breiman},
   Title = {Distinguishing benign from malignant pulmonary nodules by
             computed tomography.},
   Journal = {Radiology, UNITED STATES},
   Volume = {144},
   Number = {2},
   Pages = {349-51},
   Year = {1982},
   Month = {July},
   ISSN = {0033-8419},
   Keywords = {Calcinosis • Coin Lesion, Pulmonary • Humans
             • Lung Neoplasms • Technology, Radiologic •
             Tomography, X-Ray Computed* • radiography*},
   Abstract = {Investigators have been able to distinguish benign pulmonary
             nodules from malignant ones in about two-thirds of the cases
             studied by detecting high computed tomography (CT) numbers
             (attributed to microscopic calcifications) within many
             benign nodules. This paper reports a similar analysis on a
             series of 22 benign and 14 malignant pulmonary nodules.
             Although about one-third of the benign nodules gave high CT
             numbers, all but one of the nodules diagnosed as benign by
             CT could also be diagnosed by detection of calcification on
             plain radiographs or conventional tomograms.},
   Key = {fds132824}
}

@booklet{Johnson82e,
   Author = {Johnson, GA and Korobkin, M},
   Title = {Image techniques for multiplanar computed
             tomography.},
   Journal = {Radiology},
   Volume = {144},
   Number = {4},
   Pages = {829-834},
   Year = {1982},
   Month = {September},
   ISSN = {0033-8419},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/7111733},
   Abstract = {Hardware and software options of the GE 8800 CT scanner were
             analyzed with respect to their effect on image quality for
             multiplanar images. Phantom studies were undertaken to
             demonstrate the effect of collimation, thick pixel
             reconstruction, and interpolation of both high- and
             low-contrast multiplanar images. Noise and spatial
             resolution were measured. Thick pixel reconstruction was
             found to be most useful in aiding in the delineation of
             low-contrast lesion boundaries. In addition, this option
             permits use of lower techniques, thus speeding data
             acquisition and reducing patient dose. Clinical examples are
             included.},
   Doi = {10.1148/radiology.144.4.7111733},
   Key = {Johnson82e}
}

@article{fds132851,
   Author = {GA Johnson and M Korobkin},
   Title = {Image techniques for multiplanar computed
             tomography.},
   Journal = {Radiology, UNITED STATES},
   Volume = {144},
   Number = {4},
   Pages = {829-34},
   Year = {1982},
   Month = {September},
   ISSN = {0033-8419},
   Keywords = {Humans • Models, Structural • Radiographic Image
             Enhancement • Technology, Radiologic • Tomography,
             X-Ray Computed • methods*},
   Abstract = {Hardware and software options of the GE 8800 CT scanner were
             analyzed with respect to their effect on image quality for
             multiplanar images. Phantom studies were undertaken to
             demonstrate the effect of collimation, thick pixel
             reconstruction, and interpolation of both high- and
             low-contrast multiplanar images. Noise and spatial
             resolution were measured. Thick pixel reconstruction was
             found to be most useful in aiding in the delineation of
             low-contrast lesion boundaries. In addition, this option
             permits use of lower techniques, thus speeding data
             acquisition and reducing patient dose. Clinical examples are
             included.},
   Key = {fds132851}
}

@article{fds174214,
   Author = {GA Johnson and KJ Barsuhn and JM McCall},
   Title = {Sulfation of minoxidil by liver sulfotransferase.},
   Journal = {Biochemical pharmacology},
   Volume = {31},
   Number = {18},
   Pages = {2949-54},
   Year = {1982},
   Month = {September},
   ISSN = {0006-2952},
   Keywords = {Animals • Biotransformation • Liver • Male
             • Minoxidil • Pyrimidines • Rats • Rats,
             Inbred Strains • Sulfurtransferases • enzymology*
             • metabolism*},
   Abstract = {The 100,000 g supernatant fraction of rat liver homogenate
             contains a sulfotransferase activity which catalyzes the
             sulfation of minoxidil. Synthetic minoxidil N-O sulfate and
             the enzyme synthesized product had identical chromatographic
             characteristics on high pressure liquid chromatography.
             Minoxidil sulfate, which yields minoxidil when treated with
             sulfatase, was slowly hydrolyzed in water. Several N-oxides
             of other heterocycles, including several other pyrimidines,
             triazines and imidazoles, were also substrates for this
             sulfotransferase.},
   Language = {eng},
   Key = {fds174214}
}

@booklet{Johnson82c,
   Author = {Johnson, GA and Godwin, JD and Fram, EK},
   Title = {Gated multiplanar cardiac computed tomography.},
   Journal = {Radiology},
   Volume = {145},
   Number = {1},
   Pages = {195-197},
   Year = {1982},
   Month = {October},
   ISSN = {0033-8419},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/7122877},
   Abstract = {Multiplanar reformatting was combined with
             electrocardiographically gated computed tomography (CT) to
             provide a three-dimensional assessment of the beating heart
             of a live dog. Separate systolic and diastolic images were
             made in transverse, sagittal, coronal, and paraxial views.
             Three-dimensional contour images that outlined the cardiac
             chambers and the myocardium were then made using a separate
             research computer. This three-dimensional appreciation of
             cardiac morphology could be extended to assess regional
             function. Practical problems that limit the application of
             these methods are discussed, along with the proposed
             solutions.},
   Doi = {10.1148/radiology.145.1.7122877},
   Key = {Johnson82c}
}

@article{fds132816,
   Author = {GA Johnson and JD Godwin and EK Fram},
   Title = {Gated multiplanar cardiac computed tomography.},
   Journal = {Radiology, UNITED STATES},
   Volume = {145},
   Number = {1},
   Pages = {195-7},
   Year = {1982},
   Month = {October},
   ISSN = {0033-8419},
   Keywords = {Animals • Computers • Diatrizoate • Dogs
             • Electrocardiography* • Heart • Tomography,
             X-Ray Computed • diagnostic use • methods* •
             radiography*},
   Abstract = {Multiplanar reformatting was combined with
             electrocardiographically gated computed tomography (CT) to
             provide a three-dimensional assessment of the beating heart
             of a live dog. Separate systolic and diastolic images were
             made in transverse, sagittal, coronal, and paraxial views.
             Three-dimensional contour images that outlined the cardiac
             chambers and the myocardium were then made using a separate
             research computer. This three-dimensional appreciation of
             cardiac morphology could be extended to assess regional
             function. Practical problems that limit the application of
             these methods are discussed, along with the proposed
             solutions.},
   Key = {fds132816}
}

@booklet{Silverman82,
   Author = {Silverman, PM and Johnson, GA and Korobkin, M and Thompson,
             WM},
   Title = {High-resolution multiplanar CT images of the
             larynx.},
   Journal = {Investigative Radiology},
   Volume = {17},
   Number = {6},
   Pages = {634-637},
   Year = {1982},
   Month = {November},
   ISSN = {0020-9996},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/7152866},
   Abstract = {The standard technique for computed tomographic evaluation
             of the larynx utilizes 5-mm contiguous transaxial sections.
             Multiplanar images reformatted with these sections have not
             been of clinical use. We have evaluated the practicality of
             utilizing coronal and sagittal reformatted images produced
             from contiguous 1.5-mm transaxial sections. The technique of
             rapid sequential scanning with automatic table
             incrementation allows 36 contiguous thin section scans to be
             acquired in less than 9 minutes. Phantom studies showed a
             marked improvement in spatial resolution with thin section
             reconstructions. Preliminary clinical evaluation shows
             visualization of smaller structures with improved edge
             definition of both low- and high-contrast
             structures.},
   Key = {Silverman82}
}

@article{fds269036,
   Author = {Silverman, PM and Korobkin, M and Thompson, WM and Johnson, GA and Cole,
             TB and Fisher, SR},
   Title = {Work in progress: high-resolution, thin-section computed
             tomography of the larynx.},
   Journal = {Radiology},
   Volume = {145},
   Number = {3},
   Pages = {723-725},
   Year = {1982},
   Month = {December},
   ISSN = {0033-8419},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/7146403},
   Keywords = {Humans • Laryngeal Neoplasms • Time Factors •
             Tomography, X-Ray Computed • methods* •
             radiography*},
   Doi = {10.1148/radiology.145.3.7146403},
   Key = {fds269036}
}

@booklet{Johnson83,
   Author = {Johnson, GA and Danieley, N and Suddarth, S and Dunnick,
             NR},
   Title = {SYSTEM FOR DIGITAL VIDEODENSITOMETRY.},
   Journal = {Proceedings of SPIE - The International Society for Optical
             Engineering},
   Volume = {419},
   Pages = {222-227},
   Year = {1983},
   Key = {Johnson83}
}

@booklet{Godwin83,
   Author = {Godwin, JD and Johnson, GA and Fram, EK},
   Title = {Testing electrocardiographically-gated ct of the heart with
             a motion phantom},
   Journal = {Investigative Radiology},
   Volume = {18},
   Number = {4},
   Pages = {S33-S33},
   Year = {1983},
   Key = {Godwin83}
}

@booklet{Thompson83,
   Author = {THOMPSON, WM and STUDE, R and BATES, M and HEDLUND, L and JOHNSON,
             GA},
   Title = {CONTRAST ENHANCEMENT OF THE LIVER DURING CT - A COMPARISON
             OF BILIARY, VASCULAR AND RETICULOENDOTHELIAL
             AGENTS},
   Journal = {Investigative Radiology},
   Volume = {18},
   Number = {4},
   Pages = {S11-S11},
   Year = {1983},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1983QZ74200056&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198307000-00064},
   Key = {Thompson83}
}

@booklet{Johnson83b,
   Author = {JOHNSON, GA and DANIELEY, N and SUDDARTH, S and DUNNICK,
             NR},
   Title = {A SYSTEM FOR DIGITAL VIDEODENSITOMETRY},
   Journal = {AJR. American journal of roentgenology},
   Volume = {141},
   Number = {6},
   Pages = {1360-1361},
   Year = {1983},
   ISSN = {0361-803X},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1983RT41800084&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Johnson83b}
}

@booklet{Ravin83,
   Author = {Ravin, CE and Johnson, GA},
   Title = {The 'optimal' chest radiograph},
   Journal = {Seminars in Respiratory Medicine},
   Volume = {5},
   Number = {1},
   Pages = {1-14},
   Year = {1983},
   Key = {Ravin83}
}

@booklet{Wendling83,
   Author = {M. G. Wendling and D. W. Ducharme and G. A. Johnson and R.
             B. Mccall and D. T. Pals},
   Title = {U-54,669f - a novel hypotensive agent},
   Journal = {Federation Proceedings},
   Volume = {42},
   Number = {2},
   Pages = {162 -- 166},
   Year = {1983},
   Key = {Wendling83}
}

@booklet{Johnson83c,
   Author = {G. A. Johnson and K. J. Barsuhn and J. M.
             Mccall},
   Title = {Minoxidil sulfate, a metabolite of minoxidil},
   Journal = {Drug Metabolism And Disposition},
   Volume = {11},
   Number = {5},
   Pages = {507 -- 508},
   Year = {1983},
   Key = {Johnson83c}
}

@booklet{Johnson83d,
   Author = {G. A. Johnson},
   Title = {Synthesizer adjustments},
   Journal = {Microwaves \& Rf},
   Volume = {22},
   Number = {1},
   Pages = {15 -- 15},
   Year = {1983},
   Key = {Johnson83d}
}

@booklet{Gibson83,
   Author = {J. K. Gibson and J. A. Gifford and P. F. Kane and G. L.
             Degraaf and F. G. Robinson and J. P. Hansen and D. W. Harris and G. A. Johnson and H. S. Greenberg and D. W.
             Ducharme},
   Title = {Effects of non-steroidal anti-inflammatory drugs on
             myocardial healing after myocardial-infarction},
   Journal = {Federation Proceedings},
   Volume = {42},
   Number = {3},
   Pages = {633 -- 633},
   Year = {1983},
   Key = {Gibson83}
}

@booklet{Robinson83,
   Author = {D. S. Robinson and G. A. Johnson and A. Nies and J. Corcella and T. B. Cooper and D. Albright and D. Howard},
   Title = {Plasma-levels of catecholamines and dihydroxyphenylglycol
             during anti-depressant drug-treatment},
   Journal = {Journal Of Clinical Psychopharmacology},
   Volume = {3},
   Number = {5},
   Pages = {282 -- 287},
   Year = {1983},
   Key = {Robinson83}
}

@booklet{Thompson83a,
   Author = {W. M. Thompson and R. A. Halvorsen and R. K. Gedgaudas and F. M. Kelvin and R. P. Rice and S. Woodfield and G. A.
             Johnson and L. W. Hedlund and D. B. Jorgensen},
   Title = {High kvp vs low kvp for t-tube and operative
             cholangiography},
   Journal = {Radiology},
   Volume = {146},
   Number = {3},
   Pages = {635 -- 642},
   Year = {1983},
   Key = {Thompson83a}
}

@article{fds174067,
   Author = {MG Wendling and DW DuCharme and GA Johnson and RB McCall and DT
             Pals},
   Title = {U-54,669F: a novel hypotensive agent.},
   Journal = {Federation proceedings},
   Volume = {42},
   Number = {2},
   Pages = {162-6},
   Year = {1983},
   Month = {February},
   ISSN = {0014-9446},
   Keywords = {Angiotensin II • Animals • Antihypertensive
             Agents* • Blood Pressure • Cats •
             Dose-Response Relationship, Drug • Electric Stimulation
             • Female • Heart Rate • Macaca fascicularis
             • Male • Norepinephrine • Piperazines •
             Rats • Rats, Inbred Strains • blood • drug
             effects • drug effects* • pharmacology •
             pharmacology*},
   Abstract = {U-54,669F, a new antihypertensive agent, administered orally
             was associated with dose-related hypotensive responses in
             conscious, spontaneously hypertensive, and normotensive rats
             (0.015-0.5 mg/kg) and in supine conscious monkeys (1-10
             mg/kg). No loss of hypotensive efficacy of U-54,669F was
             observed after 1 wk of daily repetitive treatment. U-54,669F
             did not alter electrical postganglionic sympathetic nerve
             activity or postsynaptic sympathetic function. Hypotensive
             responses to U-54,669F were blunted in spinal cats.
             U-54,669F was associated with dose-related decreases in
             norepinephrine (NE) levels in plasma and in cardiac and
             splenic tissue, whereas brain NE was unaltered. U-54,669F
             attenuated vascular responses associated with electrical
             stimulation of sympathetic nerves. However, at hypotensive
             doses, U-54,669F did not impair the ability of monkeys to
             withstand orthostatic stress, or contraction of the
             nictitating membrane secondary to sympathetic stimulation in
             the cat. U-54,669F appears to alter peripheral sympathetic
             neurogenic function, but apparently does not enter the
             central nervous system and does not impair the ability to
             withstand orthostatic stress at effective hypotensive
             doses.},
   Language = {eng},
   Key = {fds174067}
}

@article{fds268910,
   Author = {Thompson, WM and Halvorsen, RA and Gedgaudas, RK and Kelvin, FM and Rice, RP and Woodfield, S and Johnson, GA and Hedlund, LW and Jorgensen,
             DB},
   Title = {High kVp vs. low kVp for T-tube and operative
             cholangiography.},
   Journal = {Radiology},
   Volume = {146},
   Number = {3},
   Pages = {635-642},
   Year = {1983},
   Month = {March},
   ISSN = {0033-8419},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/6828675},
   Keywords = {Cholangiography • Cholecystectomy • Cholelithiasis
             • Diatrizoate • Diatrizoate Meglumine •
             Humans • Intraoperative Care • Models, Structural
             • Radiation Dosage • analogs & derivatives* •
             diagnostic use* • methods* • radiography*},
   Abstract = {Based on several considerations, high kVp and high contrast
             agent concentration should produce better-quality operative
             and T-tube cholangiograms than the currently recommended low
             kVp and low contrast agent concentration. To test this
             theory, two kinds of studies were performed. In a laboratory
             phantom, the influence of kVp and contrast agent
             concentration on detectability of different size phantom
             stones was evaluated. High kVp and high contrast agent
             concentration (110 kVp, 38% iodine) were also compared with
             low kVp and low contrast agent concentration (75 kVp, 15%
             iodine) in 62 patients undergoing operative or T-tube
             cholangiography. Almost all phantom stones were well shown
             with all kVps and iodine concentrations. As the kVp was
             raised there was a mild decrease in stone detectability but
             this decrease was partially corrected by raising the iodine
             concentration. Overall stone detectability with high kVp and
             high contrast agent concentration technique was better than
             or similar to the currently recommended low kVp and low
             contrast agent concentration technique. Evaluation of the
             direct cholangiograms by five radiologists revealed that the
             high kVp, high contrast agent concentration studies were
             superior or similar to the low kVp and low contrast agent
             concentration radiographs in 70% of the cases. Based on
             these results high kVp (100-110) and a high contrast agent
             concentration (38%) are recommended for direct
             cholangiography.},
   Doi = {10.1148/radiology.146.3.6828675},
   Key = {fds268910}
}

@booklet{Silverman83,
   Author = {Silverman, PM and Johnson, GA and Korobkin, M},
   Title = {High-resolution sagittal and coronal reformatted CT images
             of the larynx.},
   Journal = {AJR. American journal of roentgenology},
   Volume = {140},
   Number = {4},
   Pages = {819-822},
   Year = {1983},
   Month = {April},
   ISSN = {0361-803X},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/6601398},
   Doi = {10.2214/ajr.140.4.819},
   Key = {Silverman83}
}

@article{fds132867,
   Author = {PM Silverman and GA Johnson and M Korobkin},
   Title = {High-resolution sagittal and coronal reformatted CT images
             of the larynx.},
   Journal = {AJR. American journal of roentgenology, UNITED
             STATES},
   Volume = {140},
   Number = {4},
   Pages = {819-22},
   Year = {1983},
   Month = {April},
   ISSN = {0361-803X},
   Keywords = {Computers • Humans • Laryngeal Neoplasms •
             Larynx • Time Factors • Tomography, X-Ray Computed
             • methods* • radiography* •
             radiotherapy},
   Key = {fds132867}
}

@article{fds174189,
   Author = {DS Robinson and GA Johnson and A Nies and J Corcella and TB Cooper and D
             Albright, D Howard},
   Title = {Plasma levels of catecholamines and dihydroxyphenylglycol
             during antidepressant drug treatment.},
   Journal = {Journal of clinical psychopharmacology},
   Volume = {3},
   Number = {5},
   Pages = {282-7},
   Year = {1983},
   Month = {October},
   ISSN = {0271-0749},
   Keywords = {Adult • Aged • Amitriptyline • Antidepressive
             Agents • Blood Platelets • Catecholamines •
             Clinical Trials as Topic • Depressive Disorder •
             Double-Blind Method • Female • Glycols •
             Humans • Male • Methoxyhydroxyphenylglycol •
             Middle Aged • Monoamine Oxidase • Phenelzine
             • Psychiatric Status Rating Scales • Time Factors
             • analogs & derivatives • blood • blood*
             • drug therapy • enzymology • therapeutic use
             • therapeutic use*},
   Abstract = {Plasma norepinephrine, epinephrine, and 3,4-dihydroxyphenylglycol
             levels were measured in depressed outpatients treated in a
             double-blind controlled clinical trial with 150 mg/day of
             amitriptyline or 60 mg/day of phenelzine for 6 weeks. Both
             antidepressant drug treatments were associated with a
             significant decline in plasma dihydroxyphenylglycol
             concentrations, which was more pronounced with phenelzine.
             Plasma norepinephrine levels also declined during phenelzine
             but not amitriptyline treatment, and the posttreatment
             values correlated with clinical improvement with the
             monoamine oxidase inhibiting drug. Reductions in
             norepinephrine and dihydroxyphenylglycol correlated highly
             with the degree of platelet monoamine oxidase inhibition.
             Mechanisms of these antidepressant drug effects on amine
             metabolism and their implications are discussed.},
   Language = {eng},
   Key = {fds174189}
}

@booklet{Johnson83a,
   Author = {Johnson, GA and Ravin, CE},
   Title = {A survey of digital chest radiography.},
   Journal = {Radiologic Clinics of North America},
   Volume = {21},
   Number = {4},
   Pages = {655-664},
   Year = {1983},
   Month = {December},
   ISSN = {0033-8389},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/6361846},
   Abstract = {The problems of chest radiography as they relate to digital
             systems are described, the current approaches to these
             problems are reviewed, and the utility of digital chest
             radiography is demonstrated.},
   Key = {Johnson83a}
}

@article{fds132853,
   Author = {GA Johnson and CE Ravin},
   Title = {A survey of digital chest radiography.},
   Journal = {Radiologic clinics of North America, UNITED
             STATES},
   Volume = {21},
   Number = {4},
   Pages = {655-64},
   Year = {1983},
   Month = {December},
   ISSN = {0033-8389},
   Keywords = {Humans • Methods • Radiographic Image Enhancement
             • Radiography, Thoracic* • Subtraction Technique*
             • Technology, Radiologic • Tomography, X-Ray
             Computed*},
   Abstract = {The problems of chest radiography as they relate to digital
             systems are described, the current approaches to these
             problems are reviewed, and the utility of digital chest
             radiography is demonstrated.},
   Key = {fds132853}
}

@booklet{Sherrier84,
   Author = {SHERRIER, RH and JOHNSON, GA and RAVIN, CE and SUDDARTH,
             SA},
   Title = {DIGITAL SYNTHESIS OF LUNG NODULES},
   Journal = {Investigative Radiology},
   Volume = {19},
   Number = {5},
   Pages = {S49-S49},
   Year = {1984},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1984TL42800213&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198409000-00219},
   Key = {Sherrier84}
}

@booklet{Drayer84,
   Author = {DRAYER, BP and HERFKENS, RJ and JOHNSON, GA and HEINZ, ER and YEATES,
             AE},
   Title = {HIGH-FIELD NMR IMAGING (1.5T) IN A HOSPITAL
             ENVIRONMENT},
   Journal = {American Journal of Neuroradiology},
   Volume = {5},
   Number = {5},
   Pages = {669-669},
   Year = {1984},
   ISSN = {0195-6108},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1984TG20900058&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Drayer84}
}

@booklet{Heinz84,
   Author = {HEINZ, ER and HERFKINS, R and JOHNSON, GA and DRAYER,
             BP},
   Title = {CAROTID-ARTERY IMAGING BY A 1.5-T MR SYSTEM},
   Journal = {American Journal of Neuroradiology},
   Volume = {5},
   Number = {5},
   Pages = {670-670},
   Year = {1984},
   ISSN = {0195-6108},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1984TG20900067&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Heinz84}
}

@booklet{Godwin84,
   Author = {GODWIN, JD and PELC, NJ and JOHNSON, GA and FRAM, EK and GOULD,
             RG},
   Title = {PROGRESS IN ECG-GATED CT - TESTING WITH A MOTION PHANTOM AND
             COMPARISON WITH THE IMATRON 50-MSEC SCANNER},
   Journal = {Investigative Radiology},
   Volume = {19},
   Number = {5},
   Pages = {S27-S27},
   Year = {1984},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1984TL42800126&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198409000-00131},
   Key = {Godwin84}
}

@booklet{Brown84,
   Author = {BROWN, MA and JOHNSON, GA},
   Title = {VARIABLE FIELD STUDIES OF POTENTIAL PARAMAGNETIC NMR
             CONTRAST AGENTS},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {1},
   Number = {2},
   Pages = {119-120},
   Year = {1984},
   ISSN = {0740-3194},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1984TF94000037&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Brown84}
}

@booklet{Hayes84,
   Author = {HAYES, CE and JOHNSON, GA and HERFKENS, RJ},
   Title = {DESIGN CONSIDERATIONS FOR SMALL ANIMAL IMAGING IN A LARGE
             BORE MRI SYSTEM},
   Journal = {Investigative Radiology},
   Volume = {19},
   Number = {5},
   Pages = {S25-S25},
   Year = {1984},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1984TL42800118&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Hayes84}
}

@booklet{Stude84,
   Author = {STUDE, R and HEDLUND, L and JOHNSON, GA and THOMPSON,
             WM},
   Title = {A CT-EVALUATION OF 3 HEPATOBILIARY CONTRAST
             AGENTS},
   Journal = {Investigative Radiology},
   Volume = {19},
   Number = {5},
   Pages = {S40-S40},
   Year = {1984},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1984TL42800179&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198409000-00184},
   Key = {Stude84}
}

@booklet{Johnson84,
   Author = {JOHNSON, GA and HERFKENS, RJ and MACFALL, JR},
   Title = {INVIVO FIELD-DEPENDENCE OF TISSUE RELAXATION-TIMES},
   Journal = {Investigative Radiology},
   Volume = {19},
   Number = {5},
   Pages = {S33-S33},
   Year = {1984},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1984TL42800149&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198409000-00154},
   Key = {Johnson84}
}

@booklet{Herfkens84,
   Author = {HERFKENS, RJ and JOHNSON, GA and GLOVER, G},
   Title = {INVIVO CHEMICAL-SHIFT IMAGING OF HYDROGEN},
   Journal = {Investigative Radiology},
   Volume = {19},
   Number = {5},
   Pages = {S42-S42},
   Year = {1984},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1984TL42800185&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198409000-00191},
   Key = {Herfkens84}
}

@booklet{Johnson84b,
   Author = {G. A. Johnson},
   Title = {Partitioned matrices satisfying certain null space
             properties},
   Journal = {Linear Algebra And Its Applications},
   Volume = {57},
   Number = {FEB},
   Pages = {75 -- 85},
   Year = {1984},
   Key = {Johnson84b}
}

@booklet{Baker84,
   Author = {C. A. Baker and J. P. Hansen and M. V. Williams and F. G.
             Robinson and J. E. Rogers and R. A. Zandt and M. G. Wendling and G. A. Johnson},
   Title = {Relationship between the physiologic activity of minoxidil
             and the plasma and tissue-levels of minoxidil and minoxidil
             sulfate},
   Journal = {Federation Proceedings},
   Volume = {43},
   Number = {3},
   Pages = {556 -- 556},
   Year = {1984},
   Key = {Baker84}
}

@booklet{Aiken84,
   Author = {J. W. Aiken and D. W. Harris and G. A. Johnson and J. H.
             Ludens and C. J. Taylor and E. O. Weselcouch and G. J.
             Wilson},
   Title = {Vasodilator and natriuretic activity extracted from rat
             atria},
   Journal = {Federation Proceedings},
   Volume = {43},
   Number = {3},
   Pages = {453 -- 453},
   Year = {1984},
   Key = {Aiken84}
}

@booklet{Johnson84a,
   Author = {G. A. Johnson},
   Title = {Retrofit control of a variable air volume system using
             variable speed drives},
   Journal = {Ashrae Journal-american Society Of Heating Refrigerating And
             Air-conditioning Engineers},
   Volume = {26},
   Number = {5},
   Pages = {44 -- 44},
   Year = {1984},
   Key = {Johnson84a}
}

@booklet{Brown84a,
   Author = {Brown, MA and Johnson, GA},
   Title = {Transition metal-chelate complexes as relaxation modifiers
             in nuclear magnetic resonance.},
   Journal = {Medical physics},
   Volume = {11},
   Number = {1},
   Pages = {67-72},
   Year = {1984},
   Month = {January},
   ISSN = {0094-2405},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/6422223},
   Abstract = {Studies are reported of relaxation modifiers for use in
             nuclear magnetic resonance (NMR) imaging systems. Chelate
             complexes of transition metal salts are under investigation
             to determine their ability to reduce the spin-lattice
             relaxation time (T1) of the nucleus under observation and to
             reduce the toxicity of the metal ion. The
             ethylenediaminetetraacetate (EDTA) complexes of FeCl3,
             GdCl3, and MnCl2 are not as effective as the respective
             salts in reducing T1 of water protons at 90 MHz. For Mn,
             this diminution in ability is offset by a significant
             reduction in toxicity. Explanations for this loss of
             effectiveness are discussed.},
   Doi = {10.1118/1.595455},
   Key = {Brown84a}
}

@booklet{Godwin84a,
   Author = {Godwin, JD and Johnson, GA and Fram, EK},
   Title = {A phantom for testing ECG-gated computed tomography of the
             heart.},
   Journal = {Investigative Radiology},
   Volume = {19},
   Number = {4},
   Pages = {279-283},
   Year = {1984},
   Month = {July},
   ISSN = {0020-9996},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/6480305},
   Abstract = {A mechanical phantom has been built to evaluate
             electrocardiographically gated computed tomography of the
             heart. The phantom simulates the heart in terms of cyclic
             changes in chamber dimensions and wall thickness. Rate and
             excursion are variable, and the cavity of the chamber can be
             filled with liquid contrast media of different degrees of
             radio-opacity. Preliminary experiments with a prototypic
             gating system are described.},
   Key = {Godwin84a}
}

@booklet{Winter85,
   Author = {WINTER, TC and JOHNSON, GA and MACFALL, JR},
   Title = {PRECISION AND ACCURACY IN THE MEASUREMENT OF T1 ON AN
             IMAGING-SYSTEM},
   Journal = {Investigative Radiology},
   Volume = {20},
   Number = {6},
   Pages = {S14-S14},
   Year = {1985},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1985ARG0500074&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Winter85}
}

@booklet{Mcadams85a,
   Author = {MCADAMS, HP and JOHNSON, GA and SUDDARTH, SA and RAVIN,
             CE},
   Title = {OPTIMIZATION OF ADAPTIVE FILTRATION FOR DIGITAL CHEST
             IMAGING},
   Journal = {Investigative Radiology},
   Volume = {20},
   Number = {6},
   Pages = {S27-S27},
   Year = {1985},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1985ARG0500122&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198509000-00133},
   Key = {Mcadams85a}
}

@booklet{Sherrier85a,
   Author = {SHERRIER, RH and SUDDARTH, SA and JOHNSON, GA and RAVIN,
             CE},
   Title = {AUTOMATED OBSERVER STUDIES ON A DIGITAL CHEST
             SYSTEM},
   Journal = {Investigative Radiology},
   Volume = {20},
   Number = {6},
   Pages = {S18-S18},
   Year = {1985},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1985ARG0500090&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Sherrier85a}
}

@booklet{Blinder85a,
   Author = {BLINDER, RA and HERFKENS, RJ and COLEMAN, RE and JOHNSON, GA and SCHENCK, JF and HART, HR and FOSTER, TH and EDELSTEIN,
             WA},
   Title = {HIGH-RESOLUTION MRI IMAGING AT 1.5T USING SURFACE
             COILS},
   Journal = {Journal of nuclear medicine : official publication, Society
             of Nuclear Medicine},
   Volume = {26},
   Number = {5},
   Pages = {P8-P8},
   Year = {1985},
   ISSN = {0161-5505},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1985AGS2100042&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Blinder85a}
}

@booklet{Blinder85,
   Author = {BLINDER, RA and HERFKENS, RJ and JOHNSON, GA and COLEMAN,
             RE},
   Title = {SURFACE COIL MOTION ARTIFACTS IN MR IMAGING},
   Journal = {Investigative Radiology},
   Volume = {20},
   Number = {6},
   Pages = {S31-S31},
   Year = {1985},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1985ARG0500138&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198509000-00149},
   Key = {Blinder85}
}

@booklet{Mcadams85,
   Author = {MCADAMS, HP and JOHNSON, GA and SUDDARTH, SA and RAVIN,
             CE},
   Title = {HISTOGRAM DIRECTED PROCESSING OF DIGITAL CHEST
             IMAGES},
   Journal = {Investigative Radiology},
   Volume = {20},
   Number = {6},
   Pages = {S18-S18},
   Year = {1985},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1985ARG0500088&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198509000-00099},
   Key = {Mcadams85}
}

@booklet{Sherrier85b,
   Author = {SHERRIER, RH and CHILES, C and SUDDARTH, SA and JOHNSON, GA and RAVIN,
             CE},
   Title = {EVALUATION OF COMPUTER SYNTHESIZED PULMONARY
             NODULES},
   Journal = {Investigative Radiology},
   Volume = {20},
   Number = {6},
   Pages = {S27-S27},
   Year = {1985},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1985ARG0500124&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Sherrier85b}
}

@article{fds268893,
   Author = {Herfkens, RJ and Johnson, GA},
   Title = {Magnetic resonance imaging at high-strength magnetic
             fields.},
   Journal = {Magnetic resonance annual},
   Pages = {197-215},
   Year = {1985},
   ISSN = {8756-9787},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3917235},
   Keywords = {Animals • Brain • Electromagnetic Fields •
             Heart • Humans • Magnetic Resonance Imaging •
             Magnetic Resonance Spectroscopy • anatomy & histology
             • instrumentation • methods*},
   Key = {fds268893}
}

@booklet{Johnson85d,
   Author = {G. A. Johnson},
   Title = {From constant air to variable},
   Journal = {Ashrae Journal-american Society Of Heating Refrigerating And
             Air-conditioning Engineers},
   Volume = {27},
   Number = {1},
   Pages = {106 -- \&},
   Year = {1985},
   Key = {Johnson85d}
}

@booklet{Baker85,
   Author = {C. A. Baker and D. W. Harris and G. A. Johnson},
   Title = {Effect of atriopeptin-ii on cyclic-nucleotide production in
             tissue-culture cells},
   Journal = {Federation Proceedings},
   Volume = {44},
   Number = {4},
   Pages = {1108 -- 1108},
   Year = {1985},
   Key = {Baker85}
}

@booklet{Dunnick85,
   Author = {N. R. Dunnick and K. K. Ford and G. A. Johnson and J. C.
             Gunnells},
   Title = {Digital intravenous subtraction angiography for
             investigating renovascular hypertension - comparison with
             hypertensive urography},
   Journal = {Southern Medical Journal},
   Volume = {78},
   Number = {6},
   Pages = {690 -- 693},
   Year = {1985},
   Key = {Dunnick85}
}

@booklet{Johnson85b,
   Author = {G. A. Johnson and G. W. Dewald and W. R. Strand and R. K.
             Winkelmann},
   Title = {Chromosome-studies in 17 patients with the sezary
             syndrome},
   Journal = {Cancer},
   Volume = {55},
   Number = {10},
   Pages = {2426 -- 2433},
   Year = {1985},
   Key = {Johnson85b}
}

@booklet{Harris85,
   Author = {D. W. Harris and C. A. Baker and H. H. Saneii and G. A.
             Johnson},
   Title = {Stimulation of cyclic-gmp formation in smooth-muscle cells
             by atriopeptin-ii},
   Journal = {Life Sciences},
   Volume = {37},
   Number = {7},
   Pages = {591 -- 597},
   Year = {1985},
   Key = {Harris85}
}

@booklet{Johnson85c,
   Author = {G. A. Johnson},
   Title = {Inverse no-matrices},
   Journal = {Linear Algebra And Its Applications},
   Volume = {64},
   Number = {JAN},
   Pages = {215 -- 222},
   Year = {1985},
   Key = {Johnson85c}
}

@article{fds132773,
   Author = {GA Johnson and GW Dewald and WR Strand and RK Winkelmann},
   Title = {Chromosome studies in 17 patients with the Sézary
             syndrome.},
   Journal = {Cancer, UNITED STATES},
   Volume = {55},
   Number = {10},
   Pages = {2426-33},
   Year = {1985},
   Month = {May},
   ISSN = {0008-543X},
   Keywords = {Adult • Aged • Chromosome Aberrations •
             Chromosomes • Female • Genetic Markers •
             Humans • Karyotyping • Male • Metaphase
             • Middle Aged • Sezary Syndrome • genetics*
             • mortality • pathology •
             ultrastructure*},
   Abstract = {Chromosome studies were done on phytohemagglutinin-stimulated
             peripheral blood from 17 patients with Sézary syndrome. A
             chromosomally abnormal clone was found in five patients:
             each patient had an abnormal chromosome 6 and four had an
             abnormal chromosome 1. Six patients without abnormal clones
             had more than 20% metaphases with random heteroploidy and
             sporadic structural anomalies. Only normal metaphases were
             seen in four patients, and no metaphases were found in two.
             Four of the five patients with an abnormal clone died, and
             their median survival from chromosome analysis was 6 months;
             only one of these patients died of lymphoma. The six
             patients with increased heteroploidy had long survivals and
             no apparent malignant process. Two of the four patients with
             normal metaphases died of malignant disease: one had
             lymphoma and the other squamous cell carcinoma. A third
             patient with normal chromosomes died of extensive visceral
             cutaneous T-cell lymphoma.},
   Key = {fds132773}
}

@booklet{Johnson85a,
   Author = {Johnson, GA and Danieley, N and Ravin, CE},
   Title = {Processing alternatives for digital chest
             imaging.},
   Journal = {Radiologic Clinics of North America},
   Volume = {23},
   Number = {2},
   Pages = {335-340},
   Year = {1985},
   Month = {June},
   ISSN = {0033-8389},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3991890},
   Abstract = {Radiographic imaging of the chest remains one of the most
             important and most challenging problems in radiology. The
             wide range of information that results from the great
             variation of radiation behind the lungs compared with that
             behind the mediastinum creates a very difficult imaging
             problem. The introduction and continued investigation of
             digital techniques have presented a potential solution to
             this problem. In this article, the authors describe the
             image-processing techniques of histogram equalization and
             adaptive filtration in digital chest imaging.},
   Key = {Johnson85a}
}

@article{fds132748,
   Author = {NR Dunnick and KK Ford and GA Johnson and JC Gunnells},
   Title = {DIgital intravenous subtraction angiography for
             investigating renovascular hypertension: comparison with
             hypertensive urography.},
   Journal = {Southern medical journal, UNITED STATES},
   Volume = {78},
   Number = {6},
   Pages = {690-3},
   Year = {1985},
   Month = {June},
   ISSN = {0038-4348},
   Keywords = {Adolescent • Adult • Aged • Female •
             Humans • Hypertension • Hypertension, Renovascular
             • Male • Middle Aged • Renal Artery •
             Renin • Subtraction Technique* • Urography* •
             blood • diagnosis • radiography •
             radiography*},
   Abstract = {We used digital intravenous subtraction angiography (DSA) to
             evaluate 105 patients with suspected renovascular
             hypertension. Unilateral renal artery stenoses were
             identified in 14 patients, two of whom had previously had
             contralateral nephrectomy. In addition, one of three renal
             transplant recipients was found to have stenosis of the
             nutrient artery. Bilateral renal artery stenosis was
             demonstrated by DSA in three patients. Of the 88 patients
             who had concomitant minute sequence (hypertensive) urography
             (HIVP) delayed excretion suggested a renal artery lesion in
             only 8 patients. In the group of 88 patients, HIVP was able
             to detect renal artery stenosis in only 50% (eight of the
             16) of patients whose stenosis was detected by DSA. When the
             patients with a single kidney are excluded, HIVP showed 62%
             (eight of 13) of the lesions detected by DSA. There were no
             significant complications in the patients examined by either
             modality. DSA has replaced HIVP as the screening examination
             for renovascular causes of hypertension in our
             institution.},
   Key = {fds132748}
}

@article{fds132752,
   Author = {GA Johnson and N Danieley and CE Ravin},
   Title = {Processing alternatives for digital chest
             imaging.},
   Journal = {Radiologic clinics of North America, UNITED
             STATES},
   Volume = {23},
   Number = {2},
   Pages = {335-40},
   Year = {1985},
   Month = {June},
   ISSN = {0033-8389},
   Keywords = {Humans • Radiographic Image Enhancement •
             Radiography, Thoracic • methods •
             methods*},
   Abstract = {Radiographic imaging of the chest remains one of the most
             important and most challenging problems in radiology. The
             wide range of information that results from the great
             variation of radiation behind the lungs compared with that
             behind the mediastinum creates a very difficult imaging
             problem. The introduction and continued investigation of
             digital techniques have presented a potential solution to
             this problem. In this article, the authors describe the
             image-processing techniques of histogram equalization and
             adaptive filtration in digital chest imaging.},
   Key = {fds132752}
}

@booklet{Sostman85,
   Author = {Sostman, HD and Gore, JC and Flye, MW and Johnson, GA and Herfkens,
             RJ},
   Title = {Time course and mechanism of alterations in proton
             relaxation during liver regeneration in the
             rat.},
   Journal = {Hepatology},
   Volume = {5},
   Number = {4},
   Pages = {538-543},
   Year = {1985},
   Month = {July},
   ISSN = {0270-9139},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/2991104},
   Abstract = {We studied the proton T1 and T2, water and lipid content of
             regenerating rat liver from 1 to 7 days after 70%
             hepatectomy. Liver from normal and sham-operated animals and
             splenic tissue from all animals were studied as controls. In
             vivo proton spectroscopy and imaging of liver was performed
             in a separate group of control and posthepatectomy rats. The
             T2 of regenerating liver, but not of sham or normal control
             liver, was prolonged. Changes in T1, relative to normal
             tissue, were found in liver and spleen of both operated
             groups. Lipid content, assessed both by extraction of tissue
             samples and by in vivo spectroscopy, was increased in
             regenerating tissue but not in controls. Water content was
             similarly increased in regenerating liver tissue. Changes in
             water and lipid content appeared to contribute to the
             alterations in proton relaxation which we
             observed.},
   Key = {Sostman85}
}

@article{fds174129,
   Author = {DW Harris and CA Baker and HH Saneii and GA Johnson},
   Title = {Stimulation of cyclic GMP formation in smooth muscle cells
             by atriopeptin II.},
   Journal = {Life sciences},
   Volume = {37},
   Number = {7},
   Pages = {591-7},
   Year = {1985},
   Month = {August},
   ISSN = {0024-3205},
   Keywords = {Animals • Atrial Natriuretic Factor • Carbachol
             • Cell Line • Cyclic GMP • Diterpenes •
             Female • Forskolin • Humans • Kidney •
             Lung • Muscle Proteins • Muscle, Smooth, Vascular
             • Nitroprusside • Pregnancy • Rabbits •
             biosynthesis* • drug effects • embryology •
             metabolism • metabolism* • pharmacology •
             pharmacology*},
   Abstract = {Addition of synthesized atriopeptin II (AP-2), a 23 amino
             acid peptide of rat atria, to rat thoracic aorta smooth
             muscle cells results in the stimulation of cyclic GMP
             production by the cells. The EC50 for the effect is 81 nM
             and a 7 fold increase occurs at 10 microM AP-2. Cyclic GMP
             levels increased within 15 seconds after the addition of
             AP-2 and were maximal at 5 minutes. Cyclic GMP levels in
             primary rabbit kidney cells were increased 15 fold by 10
             microM AP-2. However, no increase in cyclic GMP was detected
             in WI-38 fibroblast cells after the addition of 10 microM
             AP-2. Cyclic AMP levels were not affected by AP-2 in any of
             these cell systems. The effect upon cyclic GMP accumulation
             was specific for AP-2; none of the other compounds or
             peptides tested affected cyclic GMP levels.},
   Language = {eng},
   Key = {fds174129}
}

@booklet{Johnson85,
   Author = {Johnson, GA and Herfkens, RJ and Brown, MA},
   Title = {Tissue relaxation time: in vivo field dependence.},
   Journal = {Radiology},
   Volume = {156},
   Number = {3},
   Pages = {805-810},
   Year = {1985},
   Month = {September},
   ISSN = {0033-8419},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/2991980},
   Abstract = {Relaxation times (T1 and T2) were measured in vivo in
             mongrel dogs at fields of 0.3, 0.5, 1.0, 1.35, and 1.5 tesla
             (T). T1 was measured using nine values of inversion time
             ranging from 10 to 1,280 msec. T2 was measured with a
             four-point multiple spin-echo sequence. Relaxation times
             were calculated for muscle, kidney cortex, spleen, and
             adipose tissue. T2 is independent of field. A linear fit to
             the field dependence of T1 yields slopes of 400-500 msec/T
             for tissues in which the primary source of protons is water.
             The lower slope of adipose (approximately 150 msec/T)
             reflects the different mechanism of spin-lattice relaxation
             of the -CH2 protons.},
   Doi = {10.1148/radiology.156.3.2991980},
   Key = {Johnson85}
}

@article{fds132807,
   Author = {GA Johnson and RJ Herfkens and MA Brown},
   Title = {Tissue relaxation time: in vivo field dependence.},
   Journal = {Radiology, UNITED STATES},
   Volume = {156},
   Number = {3},
   Pages = {805-10},
   Year = {1985},
   Month = {September},
   ISSN = {0033-8419},
   Keywords = {Adipose Tissue • Animals • Dogs • Electron
             Spin Resonance Spectroscopy* • Kidney Cortex •
             Magnetic Resonance Spectroscopy* • Muscles •
             Spleen • anatomy & histology},
   Abstract = {Relaxation times (T1 and T2) were measured in vivo in
             mongrel dogs at fields of 0.3, 0.5, 1.0, 1.35, and 1.5 tesla
             (T). T1 was measured using nine values of inversion time
             ranging from 10 to 1,280 msec. T2 was measured with a
             four-point multiple spin-echo sequence. Relaxation times
             were calculated for muscle, kidney cortex, spleen, and
             adipose tissue. T2 is independent of field. A linear fit to
             the field dependence of T1 yields slopes of 400-500 msec/T
             for tissues in which the primary source of protons is water.
             The lower slope of adipose (approximately 150 msec/T)
             reflects the different mechanism of spin-lattice relaxation
             of the -CH2 protons.},
   Key = {fds132807}
}

@booklet{Sherrier85,
   Author = {Sherrier, RH and Johnson, GA and Suddarth, SA and Chiles, C and Hulka,
             C and Ravin, CE},
   Title = {Digital synthesis of lung nodules.},
   Journal = {Investigative Radiology},
   Volume = {20},
   Number = {9},
   Pages = {933-937},
   Year = {1985},
   Month = {December},
   ISSN = {0020-9996},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3841098},
   Abstract = {Studies evaluating observer accuracy and visual perception
             of pulmonary nodules usually are based upon test films
             obtained from clinical practice in patients with proven
             pulmonary nodules. Unfortunately, such nodules do not always
             occur in the optimal size and location to facilitate
             testing. Such studies would be enhanced by the ability to
             place nodules of desired size and location on chest
             radiographs. This report describes a method of placing a
             computer-generated (synthesized) nodule on a digitized chest
             radiograph. To demonstrate the similarity of these
             synthesized nodules to real nodules, each digitized
             radiograph with a computer-generated nodule was paired with
             a digitized chest radiograph of a patient with a clinically
             proven pulmonary nodule. A total of 22 pairs of chest
             radiographs were then shown to 13 radiologists, who were
             asked to distinguish the synthesized nodule from the real
             nodule. With this two alternative forced-choice test, the
             radiologists were only able to distinguish the synthesized
             nodule in 51% of the cases, strongly suggesting that
             computer generated nodules may be used to simulate real
             pulmonary nodules in future tests of nodule
             detection.},
   Key = {Sherrier85}
}

@article{fds132843,
   Author = {RH Sherrier and GA Johnson and SA Suddarth and C Chiles and C Hulka and CE
             Ravin},
   Title = {Digital synthesis of lung nodules.},
   Journal = {Investigative radiology, UNITED STATES},
   Volume = {20},
   Number = {9},
   Pages = {933-7},
   Year = {1985},
   Month = {December},
   ISSN = {0020-9996},
   Keywords = {Coin Lesion, Pulmonary • Humans • Lung Neoplasms
             • Radiography, Thoracic • Software • methods*
             • radiography*},
   Abstract = {Studies evaluating observer accuracy and visual perception
             of pulmonary nodules usually are based upon test films
             obtained from clinical practice in patients with proven
             pulmonary nodules. Unfortunately, such nodules do not always
             occur in the optimal size and location to facilitate
             testing. Such studies would be enhanced by the ability to
             place nodules of desired size and location on chest
             radiographs. This report describes a method of placing a
             computer-generated (synthesized) nodule on a digitized chest
             radiograph. To demonstrate the similarity of these
             synthesized nodules to real nodules, each digitized
             radiograph with a computer-generated nodule was paired with
             a digitized chest radiograph of a patient with a clinically
             proven pulmonary nodule. A total of 22 pairs of chest
             radiographs were then shown to 13 radiologists, who were
             asked to distinguish the synthesized nodule from the real
             nodule. With this two alternative forced-choice test, the
             radiologists were only able to distinguish the synthesized
             nodule in 51% of the cases, strongly suggesting that
             computer generated nodules may be used to simulate real
             pulmonary nodules in future tests of nodule
             detection.},
   Key = {fds132843}
}

@booklet{Drayer86a,
   Author = {DRAYER, B and BURGER, P and DARWIN, R and RIEDERER, S and HERFKENS, R and JOHNSON, GA},
   Title = {MAGNETIC-RESONANCE-IMAGING OF BRAIN IRON},
   Journal = {American Journal of Neuroradiology},
   Volume = {7},
   Number = {3},
   Pages = {373-380},
   Year = {1986},
   ISSN = {0195-6108},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1986C133300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Drayer86a}
}

@booklet{Johnson86b,
   Author = {Johnson, GA and Thompson, MB and Gewalt, SL and Hayes,
             CE},
   Title = {Nuclear magnetic resonance imaging at microscopic
             resolution},
   Journal = {Journal of Magnetic Resonance (1969)},
   Volume = {68},
   Number = {1},
   Pages = {129-137},
   Year = {1986},
   ISSN = {0022-2364},
   Abstract = {Resolution limits in NMR imaging are imposed by bandwidth
             considerations, available magnetic gradients for spatial
             encoding, and signal to noise. This work reports
             modification of a clinical NMR imaging device with picture
             elements of 500 × 500 × 5000 μm to yield picture elements
             of 50 × 50 × 1000 μm. Resolution has been increased by
             using smaller gradient coils permitting gradient fields
             >0.4 mT/cm. Significant improvements in signal to noise
             are achieved with smaller rf coils, close attention to
             choice of bandwidth, and signal averaging. These
             improvements permit visualization of anatomical structures
             in the rat brain with an effective diameter of 1 cm with the
             same definition as is seen in human imaging. The techniques
             and instrumentation should open a number of basic sciences
             such as embryology, plant sciences, and teratology to the
             potentials of NMR imaging. © 1986.},
   Key = {Johnson86b}
}

@booklet{Drayer86b,
   Author = {DRAYER, B and BURGER, P and CAIN, J and LEONG, J and JOHNSON, GA and HEINZ,
             ER and RIEDERER, S and DJANG, W and HERFKENS, R},
   Title = {MR IMAGING AND PERLS STAIN OF BASAL GANGLIA IRON WITH NORMAL
             AGING},
   Journal = {American Journal of Neuroradiology},
   Volume = {7},
   Number = {3},
   Pages = {554-555},
   Year = {1986},
   ISSN = {0195-6108},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1986C133300130&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Drayer86b}
}

@article{fds268884,
   Author = {Johnson, GA and Thompson, MB and Drayer, BP and Bone,
             SN},
   Title = {Magnetic resonance microscopy in neurologic
             models.},
   Journal = {Acta radiologica. Supplementum},
   Volume = {369},
   Pages = {267-268},
   Year = {1986},
   ISSN = {0365-5954},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/2980471},
   Keywords = {Animals • Brain • Chick Embryo • Magnetic
             Resonance Imaging • Rats • anatomy & histology*
             • cytology • methods*},
   Abstract = {Magnetic resonance imaging techniques have been developed to
             permit imaging with slice thickness less than 1 mm and
             pixels of 50 x 50 microns. Special purpose gradient and
             radiofrequency coils and three-dimensional imaging
             techniques enable acquisition of images with sufficient
             signal to noise to utilize these microscopic picture
             elements. Live 200 g rats were imaged enabling clear
             definition of gray and white matter structures. Examples
             include the Sylvian aqueduct and the substantia nigra.
             Three-dimensional microscopic images of live chick embryos
             enabled definition of ventricles and brain parenchyma as
             well as measurement of T1 over the set of 16 contiguous 1.2
             mm slices.},
   Key = {fds268884}
}

@booklet{Baker86,
   Author = {C. A. Baker and G. A. Johnson},
   Title = {Sulfation of minoxidil by human-platelet
             sulfotransferase},
   Journal = {Federation Proceedings},
   Volume = {45},
   Number = {3},
   Pages = {445 -- 445},
   Year = {1986},
   Month = {March},
   Key = {Baker86}
}

@booklet{Mcadams86,
   Author = {McAdams, HP and Johnson, GA and Suddarth, SA and Ravin,
             CE},
   Title = {Histogram-directed processing of digital chest
             images.},
   Journal = {Investigative Radiology},
   Volume = {21},
   Number = {3},
   Pages = {253-259},
   Year = {1986},
   Month = {March},
   ISSN = {0020-9996},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3957599},
   Abstract = {One of the potential advantages of digital chest imaging is
             the ability to process these images. However, such
             processing, when uniformly applied to the entire image, is
             often unsatisfactory due to the different processing
             requirements of lung field and mediastinum. Therefore, a
             method to selectively process these regions based upon the
             histogram of the original image has been developed. Thirteen
             conventional chest films were digitized with a laser film
             scanner. Analysis of individual lung field and mediastinum
             histograms showed that the chest image histogram is
             essentially bimodal with significant lung field-mediastinum
             histogram peak separation; overlap between these peaks is
             small (9% of the total histogram) and insensitive to minor
             pathologic change or radiographic technique. Using these
             histograms, a gray level threshold distinguishing
             mediastinum from lung field was selected and used to direct
             the regionally-selective processing of several chest images.
             This technique may prove especially useful for digital
             enhancement of the underexposed mediastinum often
             encountered on conventional chest radiographs.},
   Key = {Mcadams86}
}

@article{fds132872,
   Author = {HP McAdams and GA Johnson and SA Suddarth and CE Ravin},
   Title = {Histogram-directed processing of digital chest
             images.},
   Journal = {Investigative radiology, UNITED STATES},
   Volume = {21},
   Number = {3},
   Pages = {253-9},
   Year = {1986},
   Month = {March},
   ISSN = {0020-9996},
   Keywords = {Computers • Humans • Lasers • Lung •
             Mediastinum • Radiographic Image Enhancement •
             Radiography, Thoracic • methods* •
             radiography},
   Abstract = {One of the potential advantages of digital chest imaging is
             the ability to process these images. However, such
             processing, when uniformly applied to the entire image, is
             often unsatisfactory due to the different processing
             requirements of lung field and mediastinum. Therefore, a
             method to selectively process these regions based upon the
             histogram of the original image has been developed. Thirteen
             conventional chest films were digitized with a laser film
             scanner. Analysis of individual lung field and mediastinum
             histograms showed that the chest image histogram is
             essentially bimodal with significant lung field-mediastinum
             histogram peak separation; overlap between these peaks is
             small (9% of the total histogram) and insensitive to minor
             pathologic change or radiographic technique. Using these
             histograms, a gray level threshold distinguishing
             mediastinum from lung field was selected and used to direct
             the regionally-selective processing of several chest images.
             This technique may prove especially useful for digital
             enhancement of the underexposed mediastinum often
             encountered on conventional chest radiographs.},
   Key = {fds132872}
}

@booklet{Harris86,
   Author = {D. W. Harris and D. M. Sutter and G. A. Johnson and J. H.
             Ludens},
   Title = {Immunoreactive atrial natriuretic factors (ir-anf) in plasma
             of conscious, unperturbed doca-salt hypertensive
             rats},
   Journal = {Clinical Research},
   Volume = {34},
   Number = {2},
   Pages = {A479 -- A479},
   Year = {1986},
   Month = {April},
   Key = {Harris86}
}

@booklet{Drayer86c,
   Author = {Drayer, BP and Olanow, W and Burger, P and Johnson, GA and Herfkens, R and Riederer, S},
   Title = {Parkinson plus syndrome: diagnosis using high field MR
             imaging of brain iron.},
   Journal = {Radiology},
   Volume = {159},
   Number = {2},
   Pages = {493-498},
   Year = {1986},
   Month = {May},
   ISSN = {0033-8419},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3961182},
   Abstract = {The distribution of iron in the brain was analyzed using
             high field strength (1.5 T) magnetic resonance (MR) imaging
             in 14 healthy control individuals and six patients with
             Parkinson plus syndromes (multisystem atrophy and
             progressive supranuclear palsy) who were unresponsive to
             antiparkinsonian therapy. The normal topographic
             distribution of iron in the brain as indicated by high field
             MR images coincided precisely with the distribution of iron
             in the brain as determined by Perls staining for ferric
             iron. In Parkinson plus syndromes, there were abnormally
             increased concentrations of iron (decreased T2 relaxation
             times) in the putamen, and less prominent increases in the
             caudate nucleus and lateral pars compacta of the substantia
             nigra. In high field strength MR images of normal patients,
             the decreased signal intensity in the globus pallidus is
             more prominent than that of the putamen. In MR images of
             patients with Parkinson plus syndromes, the decreased signal
             intensity of the putamen is more prominent than that of the
             globus pallidus.},
   Doi = {10.1148/radiology.159.2.3961182},
   Key = {Drayer86c}
}

@article{fds132856,
   Author = {BP Drayer and W Olanow and P Burger and GA Johnson and R Herfkens and S
             Riederer},
   Title = {Parkinson plus syndrome: diagnosis using high field MR
             imaging of brain iron.},
   Journal = {Radiology, UNITED STATES},
   Volume = {159},
   Number = {2},
   Pages = {493-8},
   Year = {1986},
   Month = {May},
   ISSN = {0033-8419},
   Keywords = {Adult • Aged • Atrophy • Cerebellar Nuclei
             • Globus Pallidus • Humans • Iron •
             Magnetic Resonance Spectroscopy • Middle Aged •
             Parkinson Disease • Putamen • Substantia Nigra
             • analysis • analysis* • diagnosis* •
             diagnostic use* • pathology},
   Abstract = {The distribution of iron in the brain was analyzed using
             high field strength (1.5 T) magnetic resonance (MR) imaging
             in 14 healthy control individuals and six patients with
             Parkinson plus syndromes (multisystem atrophy and
             progressive supranuclear palsy) who were unresponsive to
             antiparkinsonian therapy. The normal topographic
             distribution of iron in the brain as indicated by high field
             MR images coincided precisely with the distribution of iron
             in the brain as determined by Perls staining for ferric
             iron. In Parkinson plus syndromes, there were abnormally
             increased concentrations of iron (decreased T2 relaxation
             times) in the putamen, and less prominent increases in the
             caudate nucleus and lateral pars compacta of the substantia
             nigra. In high field strength MR images of normal patients,
             the decreased signal intensity in the globus pallidus is
             more prominent than that of the putamen. In MR images of
             patients with Parkinson plus syndromes, the decreased signal
             intensity of the putamen is more prominent than that of the
             globus pallidus.},
   Key = {fds132856}
}

@booklet{Drayer86,
   Author = {Drayer, B and Burger, P and Darwin, R and Riederer, S and Herfkens, R and Johnson, GA},
   Title = {MRI of brain iron.},
   Journal = {AJR. American journal of roentgenology},
   Volume = {147},
   Number = {1},
   Pages = {103-110},
   Year = {1986},
   Month = {July},
   ISSN = {0361-803X},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3487201},
   Abstract = {A prominently decreased signal intensity in the globus
             pallidum, reticular substantia nigra, red nucleus, and
             dentate nucleus was routinely noted in 150 consecutive
             individuals on T2-weighted images (SE 2000/100) using a high
             field strength (1.5 T)MR system. This MR finding correlated
             closely with the decreased estimated T2 relaxation times and
             the sites of preferential accumulation of ferric iron using
             the Perls staining method on normal postmortem brains. The
             decreased signal intensity on T2-weighted images thus
             provides an accurate in vivo map of the normal distribution
             of brain iron. Perls stain and MR studies in normal brain
             also confirm an intermediate level of iron distribution in
             the striatum, and still lower levels in the cerebral gray
             and white matter. In the white matter, iron concentration is
             (a) absent in the most posterior portion of the internal
             capsule and optic radiations, (b) higher in the frontal than
             occipital regions, and (c) prominent in the subcortical "U"
             fibers, particularly in the temporal lobe. There is no iron
             in the brain at birth; it increases progressively with
             aging. Knowledge of the distribution of brain iron should
             assist in elucidating normal anatomic structures and in
             understanding neurodegenerative, demyelinating, and
             cerebrovascular disorders.},
   Doi = {10.2214/ajr.147.1.103},
   Key = {Drayer86}
}

@article{fds132822,
   Author = {B Drayer and P Burger and R Darwin and S Riederer and R Herfkens and GA
             Johnson},
   Title = {MRI of brain iron.},
   Journal = {AJR. American journal of roentgenology, UNITED
             STATES},
   Volume = {147},
   Number = {1},
   Pages = {103-10},
   Year = {1986},
   Month = {July},
   ISSN = {0361-803X},
   Keywords = {Adolescent • Adult • Aged • Aging •
             Brain • Brain Chemistry* • Brain Diseases •
             Child • Globus Pallidus • Humans • Iron
             • Magnetic Resonance Spectroscopy • Male •
             Middle Aged • Substantia Nigra • analysis •
             analysis* • diagnostic use* • metabolism •
             pathology},
   Abstract = {A prominently decreased signal intensity in the globus
             pallidum, reticular substantia nigra, red nucleus, and
             dentate nucleus was routinely noted in 150 consecutive
             individuals on T2-weighted images (SE 2000/100) using a high
             field strength (1.5 T)MR system. This MR finding correlated
             closely with the decreased estimated T2 relaxation times and
             the sites of preferential accumulation of ferric iron using
             the Perls staining method on normal postmortem brains. The
             decreased signal intensity on T2-weighted images thus
             provides an accurate in vivo map of the normal distribution
             of brain iron. Perls stain and MR studies in normal brain
             also confirm an intermediate level of iron distribution in
             the striatum, and still lower levels in the cerebral gray
             and white matter. In the white matter, iron concentration is
             (a) absent in the most posterior portion of the internal
             capsule and optic radiations, (b) higher in the frontal than
             occipital regions, and (c) prominent in the subcortical "U"
             fibers, particularly in the temporal lobe. There is no iron
             in the brain at birth; it increases progressively with
             aging. Knowledge of the distribution of brain iron should
             assist in elucidating normal anatomic structures and in
             understanding neurodegenerative, demyelinating, and
             cerebrovascular disorders.},
   Key = {fds132822}
}

@booklet{Pals86a,
   Author = {D. T. Pals and S. Thaisrivongs and J. A. Lawson and W. M.
             Kati and S. R. Turner and G. L. Degraaf and D. W. Harris and G. A. Johnson},
   Title = {An orally-active inhibitor of renin},
   Journal = {Hypertension},
   Volume = {8},
   Number = {9},
   Pages = {833 -- 833},
   Year = {1986},
   Month = {September},
   Key = {Pals86a}
}

@booklet{Hedlund86b,
   Author = {HEDLUND, L and JOHNSON, GA},
   Title = {MAGNETIC-RESONANCE-IMAGING OF THE RAT THORAX AND
             ABDOMEN},
   Journal = {Investigative Radiology},
   Volume = {21},
   Number = {9},
   Pages = {S14-S14},
   Year = {1986},
   Month = {September},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1986E000900063&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198609000-00071},
   Key = {Hedlund86b}
}

@booklet{Karis86,
   Author = {KARIS, JP and GLOVER, GH and JOHNSON, GA},
   Title = {VARIANT ANGLE GRADIENT REFOCUSING IN 3-DIMENSIONAL MRI
             MICROSCOPY},
   Journal = {Investigative Radiology},
   Volume = {21},
   Number = {9},
   Pages = {S34-S34},
   Year = {1986},
   Month = {September},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1986E000900141&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Karis86}
}

@booklet{Johnson86a,
   Author = {JOHNSON, GA and THOMPSON, MB and DRAYER, BP},
   Title = {3-DIMENSIONAL MRI MICROSCOPY OF THE RAT-BRAIN},
   Journal = {Investigative Radiology},
   Volume = {21},
   Number = {9},
   Pages = {S25-S25},
   Year = {1986},
   Month = {September},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1986E000900109&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Johnson86a}
}

@booklet{Bone86a,
   Author = {BONE, SN and JOHNSON, GA and THOMPSON, MB},
   Title = {MRI MICROSCOPY OF THE DEVELOPING CHICK-EMBRYO},
   Journal = {Investigative Radiology},
   Volume = {21},
   Number = {9},
   Pages = {S34-S34},
   Year = {1986},
   Month = {September},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1986E000900143&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Bone86a}
}

@booklet{Johnston86,
   Author = {D. G. Johnston and G. A. Johnson and K. G. M. M. Alberti and G. H. Millwardsadler and J. Mitchell and R.
             Wright},
   Title = {Hepatic regeneration and metabolism after
             partial-hepatectomy in normal rats - effects of insulin
             therapy},
   Journal = {European Journal Of Clinical Investigation},
   Volume = {16},
   Number = {5},
   Pages = {376 -- 383},
   Year = {1986},
   Month = {October},
   Key = {Johnston86}
}

@booklet{Johnston86a,
   Author = {D. G. Johnston and G. A. Johnson and K. G. M. M. Alberti and G. H. Millwardsadler and J. Mitchell and R.
             Wright},
   Title = {Hepatic regeneration and metabolism after
             partial-hepatectomy in diabetic rats - effects of insulin
             therapy},
   Journal = {European Journal Of Clinical Investigation},
   Volume = {16},
   Number = {5},
   Pages = {384 -- 390},
   Year = {1986},
   Month = {October},
   Key = {Johnston86a}
}

@booklet{Johnson86,
   Author = {JOHNSON, GA and BAILEY, JE and BRUCK, RI and MATYAC,
             CA},
   Title = {STUDIES OF DISEASED ROOT-TISSUE USING NUCLEAR-MAGNETIC-RESONANCE
             IMAGING},
   Journal = {Phytopathology},
   Volume = {76},
   Number = {10},
   Pages = {1067-1067},
   Year = {1986},
   Month = {October},
   ISSN = {0031-949X},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1986F034600096&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Johnson86}
}

@booklet{Bone86,
   Author = {BONE, SN and JOHNSON, GA and THOMPSON, MB},
   Title = {3-DIMENSIONAL MAGNETIC-RESONANCE MICROSCOPY OF THE
             DEVELOPING CHICK-EMBRYO},
   Journal = {Investigative Radiology},
   Volume = {21},
   Number = {10},
   Pages = {782-787},
   Year = {1986},
   Month = {October},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1986E347800003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198610000-00003},
   Key = {Bone86}
}

@article{fds161595,
   Author = {DG Johnston and GA Johnson and KG Alberti and GH Millward-Sadler and J
             Mitchell, R Wright},
   Title = {Hepatic regeneration and metabolism after partial
             hepatectomy in normal rats: effects of insulin
             therapy.},
   Journal = {European journal of clinical investigation,
             ENGLAND},
   Volume = {16},
   Number = {5},
   Pages = {376-83},
   Year = {1986},
   Month = {October},
   ISSN = {0014-2972},
   Keywords = {Adenine Nucleotides • Animals • DNA • Glucose
             • Glycogen • Hepatectomy* • Insulin •
             Liver • Liver Regeneration • Male • Organ
             Size • Rats • Rats, Inbred Strains •
             Thymidine • Water • analysis • biosynthesis
             • cytology • drug effects* • metabolism
             • metabolism* • therapeutic use*},
   Abstract = {The effect of insulin therapy on liver regeneration has been
             studied in normal fed rats 12, 24 and 48 h after partial
             hepatectomy. Dry weight of regenerating liver increased
             between 12 and 48 h after partial hepatectomy and was
             unaffected by insulin therapy. [6-3H] Thymidine uptake
             peaked at 24-h (24.7 +/- 2.4% of total liver cells) and
             insulin treatment had no additional effect. At 12-h after
             partial hepatectomy, hepatic [ATP] was decreased 15%, while
             [ADP] and [AMP] were increased 47% and 83% respectively
             compared with sham-operated animals. Partial hepatectomy
             also caused an increase in hepatic [triglyceride], a
             decrease in hepatic [glycogen] and an increase in the levels
             of glucose and several glycolytic intermediates. The hepatic
             redox ratios, [lactate]:[pyruvate] and [3-hydroxybutyrate]:[acetoacetate],
             were elevated. Insulin therapy had only minor effects on
             hepatic adenine nucleotide levels, intermediary metabolite
             concentrations or intrahepatic redox ratios after partial
             hepatectomy. These findings suggest a decreased hepatic
             intracellular energy state in regenerating liver; insulin
             therapy in normal rats does not influence this metabolic
             change nor the regenerative response.},
   Key = {fds161595}
}

@article{fds174225,
   Author = {DG Johnston and GA Johnson and KG Alberti and GH Millward-Sadler and J
             Mitchell, R Wright},
   Title = {Hepatic regeneration and metabolism after partial
             hepatectomy in diabetic rats: effects of insulin
             therapy.},
   Journal = {European journal of clinical investigation},
   Volume = {16},
   Number = {5},
   Pages = {384-90},
   Year = {1986},
   Month = {October},
   ISSN = {0014-2972},
   Keywords = {Adenine Nucleotides • Animals • DNA •
             Diabetes Mellitus, Experimental • Glucose •
             Hepatectomy* • Insulin • Lactates • Lactic
             Acid • Liver • Liver Glycogen • Liver
             Regeneration • Male • Organ Size • Pyruvates
             • Pyruvic Acid • Rats • Rats, Inbred Strains
             • Water • analysis • biosynthesis •
             blood • drug effects* • drug therapy •
             metabolism • metabolism* • therapeutic
             use*},
   Abstract = {The effect of insulin deficiency on liver regeneration has
             been assessed in untreated v. insulin-treated streptozotocin
             (65 mg kg-1) diabetic rats, 12, 24 and 48 h after partial
             hepatectomy. Dry weight of regenerating liver increased from
             12 to 48 h after partial hepatectomy and insulin treatment
             caused a further minor increase at 24 h. [6-3H]Thymidine
             uptake in untreated rats peaked at 24 h (12.5 +/- 3.4% of
             total cells labelled). Insulin therapy produced a delayed
             168% rise in uptake at 48 h. Insulin deficiency alone in
             sham-operated animals caused a 33% decrease in hepatic
             [ATP], while [ADP] rose by 43% and [AMP] by 86% at 12 h.
             Partial hepatectomy produced only minor further
             abnormalities in untreated animals. Insulin therapy
             increased hepatic [ATP] and decreased [ADP] and [AMP] 12 h
             after partial hepatectomy, but [ATP] remained decreased
             (15%) and [ADP] and [AMP] increased (45% and 73%
             respectively) compared with insulin-treated sham-operated
             controls. Metabolite changes observed after partial
             hepatectomy in untreated animals, including a decrease in
             hepatic [glycogen] and increases in [triglyceride] and the
             ratios of [lactate]:[pyruvate] and [3-hydroxybutyrate]:[acetoacetate],
             were partially reversed by insulin treatment. Insulin
             deficiency thus impairs regeneration after partial
             hepatectomy and magnifies the decline in hepatic
             intracellular energy state and the metabolite changes
             associated with liver regrowth.},
   Language = {eng},
   Key = {fds174225}
}

@article{fds268895,
   Author = {Bone, SN and Johnson, GA and Thompson, MB},
   Title = {Three-dimensional magnetic resonance microscopy of the
             developing chick embryo.},
   Journal = {Investigative Radiology},
   Volume = {21},
   Number = {10},
   Pages = {782-787},
   Year = {1986},
   Month = {October},
   ISSN = {0020-9996},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3771148},
   Keywords = {Animals • Chick Embryo • Eye • Magnetic
             Resonance Spectroscopy • Microscopy • cytology
             • diagnostic use* • embryology • growth &
             development* • instrumentation •
             methods},
   Abstract = {Magnetic resonance imaging microscopy was performed on live
             chick embryos. A combination of high gradient strength (0.47
             mT/cm), special purpose radiofrequency coils and
             3-dimensional Fourier imaging was used to obtain images with
             effective thickness of 1.25 mm and pixel dimensions as small
             as 200 mu in the live chick embryo. The signal-to-noise
             ratio was sufficient to allow unequivocal identification of
             the individual chambers of the heart, spinal cord,
             ventricles in the brain, and vascular structures in the
             liver of a live 11-day embryo. Anatomical assignment was
             accomplished with the aid of correlated histologic sections.
             Because there are no external landmarks, the plane of
             imaging is frequently oblique, making the 3-dimensional
             acquisition particularly useful.},
   Key = {fds268895}
}

@booklet{Hedlund86a,
   Author = {L. W. Hedlund and G. A. Johnson and G. I.
             Mills},
   Title = {Magnetic-resonance microscopy of the rat thorax and
             abdomen},
   Journal = {Investigative Radiology},
   Volume = {21},
   Number = {11},
   Pages = {843 -- 846},
   Year = {1986},
   Month = {November},
   Key = {Hedlund86a}
}

@booklet{Hedlund86,
   Author = {Hedlund, LW and Johnson, GA and Karis, JP and Effmann,
             EL},
   Title = {MR "microscopy" of the rat thorax.},
   Journal = {Journal of Computer Assisted Tomography},
   Volume = {10},
   Number = {6},
   Pages = {948-952},
   Year = {1986},
   Month = {November},
   ISSN = {0363-8715},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3782566},
   Abstract = {High resolution images can be obtained from anywhere in the
             body of small animals with magnetic resonance combined with
             cardiac gating and scan synchronous ventilation. We used
             these methods to examine the intrathoracic anatomy of the
             rat. Anesthetized rats were intubated and ventilated in
             synchrony with imaging acquisition. Images were obtained in
             a 1 m bore, 1.5 T system fitted with a 28 cm diameter high
             field gradient coil and a 5 cm radio-frequency coil. We used
             cardiac gated, three-dimensional spin warp acquisitions.
             Eight contiguous slices (2.5 mm thick) were obtained
             simultaneously. In addition to visualizing major vessels and
             cardiac chambers, cardiac valves and papillary muscles were
             clearly demonstrated. Major pulmonary vessels and peripheral
             parenchyma were also seen. These results demonstrate MR
             "microscopy" can be used to image all major cardiopulmonary
             structures in the rat with respect to selected times of the
             cardiac cycle. This capability for noninvasive "microscopy"
             opens new avenues for cardiopulmonary research using well
             characterized rodent models.},
   Key = {Hedlund86}
}

@article{fds268993,
   Author = {Hedlund, LW and Johnson, GA and Mills, GI},
   Title = {Magnetic resonance microscopy of the rat thorax and
             abdomen.},
   Journal = {Investigative Radiology},
   Volume = {21},
   Number = {11},
   Pages = {843-846},
   Year = {1986},
   Month = {November},
   ISSN = {0020-9996},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3781788},
   Keywords = {Abdomen • Animals • Magnetic Resonance
             Spectroscopy • Male • Myocardial Contraction
             • Rats • Rats, Inbred Strains • Respiration
             • Thorax • anatomy & histology* • diagnostic
             use},
   Abstract = {With magnetic resonance (MR) microscopy, high-resolution
             volumetric imaging (3DFT) of small animals is possible.
             Although these techniques are suitable for imaging the head
             and other small stationary objects, breathing and cardiac
             motion degrade the quality of body images. Scan synchronous
             ventilation and cardiac gating methods have been developed
             that permit acquisition of high-resolution images from
             anywhere in the body of small animals (150 to 400 g).
             Anesthetized rats were ventilated in synchrony with
             three-dimensional Fourier spin warp (3DFT) sequence (TR =
             400 to 1000 ms, TE = 20 ms). Eight or 16 slices (1.2 or 2.5
             mm thick) were acquired simultaneously. Effective pixel size
             was 200 X 200 mu. Imaging was performed in a 1.5 T, 1-m bore
             research system using a 28-cm diameter high field gradient
             coil and a 6-cm diameter radio frequency coil. For thoracic
             imaging, acquisitions were gated to the QRS of the ECG. Scan
             synchronous ventilation eliminated breathing motion
             artifacts and permitted visualization of peripheral vascular
             structures in the lung and liver. In images that were also
             cardiac gated, cardiac chambers and major thoracic vessels,
             including the coronary arteries, were well demonstrated.
             Thus, thoroughly characterized rodent models can now be
             studied with MR not only to explore noninvasively the
             intricacies of mammalian pathomorphology, but also to test
             the capabilities of MR and aid in interpreting MR
             data.},
   Key = {fds268993}
}

@booklet{Pals86,
   Author = {D. T. Pals and S. Thaisrivongs and J. A. Lawson and W. M.
             Kati and S. R. Turner and G. L. Degraaf and D. W. Harris and G. A. Johnson},
   Title = {An orally active inhibitor of renin},
   Journal = {Hypertension},
   Volume = {8},
   Number = {12},
   Pages = {1105 -- 1112},
   Year = {1986},
   Month = {December},
   Key = {Pals86}
}

@booklet{Brown86,
   Author = {Brown, JM and Johnson, GA and Kramer, PJ},
   Title = {In Vivo Magnetic Resonance Microscopy of Changing Water
             Content in Pelargonium hortorum Roots.},
   Journal = {Plant physiology},
   Volume = {82},
   Number = {4},
   Pages = {1158-1160},
   Year = {1986},
   Month = {December},
   ISSN = {0032-0889},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/16665154},
   Abstract = {Magnetic resonance imaging (MRI) was used to
             nondestructively observe changes in water content in roots
             of Pelargonium hortorum x Bailey during a period of
             relatively rapid transpiration. Anatomical regions of the
             root could be differentiated with a spatial resolution of
             0.1 x 0.1 mm. MRI shows great potential for study of
             plant-water relations.},
   Key = {Brown86}
}

@article{fds157096,
   Author = {JM Brown and GA Johnson and PJ Kramer},
   Title = {In Vivo Magnetic Resonance Microscopy of Changing Water
             Content in Pelargonium hortorum Roots.},
   Journal = {Plant physiology},
   Volume = {82},
   Number = {4},
   Pages = {1158-1160},
   Year = {1986},
   Month = {December},
   ISSN = {0032-0889},
   Abstract = {Magnetic resonance imaging (MRI) was used to
             nondestructively observe changes in water content in roots
             of Pelargonium hortorum x Bailey during a period of
             relatively rapid transpiration. Anatomical regions of the
             root could be differentiated with a spatial resolution of
             0.1 x 0.1 mm. MRI shows great potential for study of
             plant-water relations.},
   Key = {fds157096}
}

@article{fds174084,
   Author = {DT Pals and S Thaisrivongs and JA Lawson and WM Kati, SR Turner and GL
             DeGraaf, DW Harris and GA Johnson},
   Title = {An orally active inhibitor of renin.},
   Journal = {Hypertension},
   Volume = {8},
   Number = {12},
   Pages = {1105-12},
   Year = {1986},
   Month = {December},
   ISSN = {0194-911X},
   Keywords = {Administration, Oral • Animals • Blood Pressure
             • Dose-Response Relationship, Drug • Heart Rate
             • Humans • Macaca fascicularis • Male •
             Oligopeptides • Rats • Rats, Inbred Strains •
             Renin • Renin-Angiotensin System • Sodium •
             antagonists & inhibitors* • drug effects •
             pharmacology* • physiology},
   Abstract = {A potent renin inhibitor, U-71038 (Boc-Pro-Phe-N-MeHis-Leu
             psi[CHOHCH2]Val-Ile-Amp), was tested for oral effectiveness.
             Enzyme kinetic studies indicated that U-71038 was a
             competitive inhibitor of hog renin with an inhibitor
             constant (Ki) value of 12 nM. Intravenous as well as oral
             administration of U-71038 to anesthetized, ganglion-blocked
             rats infused with hog renin elicited dose-related
             hypotensive responses. Intravenous administration of U-71038
             to conscious, sodium-depleted monkeys caused dose-related
             decreases of blood pressure and plasma renin activity
             without affecting heart rate. Similarly, the oral
             administration of U-71038 at 50 mg/kg to conscious,
             sodium-depleted monkeys elicited a pronounced hypotension
             and decrease in plasma renin activity that persisted for 5
             hours. The hypotensive responses elicited by intravenous and
             oral administration of U-71038 to hog renin-infused rats and
             sodium-depleted monkeys were shown to be due entirely to
             inhibition of the renin-angiotensin system. A comparison of
             the results obtained after the intravenous administration of
             U-71038 with the results obtained after the oral
             administration of U-71038 implied that at least 10% of the
             orally administered U-71038 must have been absorbed to cause
             the observed effects in hog renin-infused rats and
             sodium-depleted monkeys. The studies demonstrated that an
             inhibitor of renin with a long duration of action and with
             oral effectiveness is a feasible entity.},
   Language = {eng},
   Key = {fds174084}
}

@article{fds132754,
   Author = {JR MacFall and FW Wehrli and RK Breger and GA Johnson},
   Title = {Methodology for the measurement and analysis of relaxation
             times in proton imaging.},
   Journal = {Magnetic resonance imaging, UNITED STATES},
   Volume = {5},
   Number = {3},
   Pages = {209-20},
   Year = {1987},
   ISSN = {0730-725X},
   Keywords = {Gadolinium • Magnetic Resonance Spectroscopy •
             Protons • Solutions • instrumentation •
             methods*},
   Abstract = {Measurements of proton T1 and T2 were performed on GdCl3
             solutions (20 less than T2 less than 500 msec, 90 less than
             T1 less than 1000 msec) on large-bore NMR imaging systems
             operating at 1.0T and 1.5T. CPMG multi-echo (ME), multiple
             saturation recovery (MSR) and modified fast inversion
             recovery (MFIR) pulse sequences as well as a sequence that
             combines and interleaves T1 and T2 weighted data acquisition
             (which we call "multiple saturation-recovery multiple-echo"
             (MSRME) were used. The relaxation data are compared to those
             obtained on a small bore NMR spectrometer operated at 1.5T.
             T1 and T2 values for the solutions were found to be the same
             within 10% for the two fields. Reproducibility of
             measurements of T1, T2 and the unnormalized spin density of
             the solutions was better than 5%. Systematic errors,
             amenable to correction through calibration, are noted in the
             imager T1 and T2 values. T1 and T2 values for some typical
             neural tissues at 1.5T and body tissue at 1.0T for human
             volunteers were obtained and are tabulated.},
   Key = {fds132754}
}

@article{fds132800,
   Author = {EK Fram and RJ Herfkens and GA Johnson and GH Glover and JP Karis and A
             Shimakawa, TG Perkins and NJ Pelc},
   Title = {Rapid calculation of T1 using variable flip angle gradient
             refocused imaging.},
   Journal = {Magnetic resonance imaging, UNITED STATES},
   Volume = {5},
   Number = {3},
   Pages = {201-8},
   Year = {1987},
   ISSN = {0730-725X},
   Keywords = {Humans • Magnetic Resonance Spectroscopy •
             diagnostic use* • methods},
   Abstract = {We present a method for rapid measurement of T1 relaxation
             times using gradient refocused images at limited flip angles
             and short repetition times. This "variable nutation"
             techniques was investigated using a T1 phantom. There was a
             high correlation between measurements obtained with the
             variable nutation and partial saturation techniques. The
             ability of this method to create calculated T1 images is
             also demonstrated. We conclude that the variable nutation
             method may allow measurement of T1 relaxation times with a
             significant reduction in acquisition time compared to
             partial saturation techniques.},
   Key = {fds132800}
}

@article{fds157104,
   Author = {RH Sherrier and GA Johnson},
   Title = {Regionally adaptive histogram equalization of the
             chest.},
   Journal = {IEEE transactions on medical imaging, United
             States},
   Volume = {6},
   Number = {1},
   Pages = {1-7},
   Year = {1987},
   ISSN = {0278-0062},
   Abstract = {Advances in the area of digital chest radiography have
             resulted in the acquisition of high-quality images of the
             human chest. With these advances, there arises a genuine
             need for image processing algorithms specific to the chest,
             in order to fully exploit this digital technology. We have
             implemented the well-known technique of histogram
             equalization, noting the problems encountered when it is
             adapted to chest images. These problems have been
             successfully solved with our regionally adaptive histogram
             equalization method. With this technique histograms are
             calculated locally and then modified according to both the
             mean pixel value of that region as well as certain
             characteristics of the cumulative distribution function.
             This process, which has allowed certain regions of the chest
             radiograph to be enhanced differentially, may also have
             broader implications for other image processing
             tasks.},
   Key = {fds157104}
}

@booklet{Karis87,
   Author = {Karis, JP and Johnson, GA and Glover, GH},
   Title = {Signal-to-noise improvements in three-dimensional NMR
             microscopy using limited-angle excitation},
   Journal = {Journal of Magnetic Resonance (1969)},
   Volume = {71},
   Number = {1},
   Pages = {24-33},
   Year = {1987},
   ISSN = {0022-2364},
   Abstract = {The 3D FT variant of spin-echo imaging has previously been
             successfully used to yield images at microscopic resolution.
             In obtaining such high resolution, optimization of signal to
             noise for a given acquisition time is crucial. Using a
             limited-angle (<60) slice-selective pulse one can improve
             the effective signal to noise or reduce the experimental
             time. The spin echo is generated through gradient
             refocusing. A phantom with T1 of 800 and 1200 ms was used to
             simulate white and gray matter. Signal intensity was modeled
             by the expression M= M0sinθ[1-exp(- TR T1)] 1-exp(- TR
             T1)cosθ For TR < 200 ms, limited-angle excitation can
             yield improvements in signal to noise by greater than a
             factor of two. These results were experimentally verified on
             a 1.5 T prototype system (General Electric, Milwaukee, Wis.)
             configured with gradient and rf coils designed for NMR
             microscopy. In those cases where signal-to-noise concerns do
             not require signal averaging beyond that which is inherent
             in the 3D FT technique, the limited-angle approach can
             reduce the acquisition time by as much as a factor of four.
             These results were verified in small animal studies of the
             brain of a 200 g rat. © 1987.},
   Key = {Karis87}
}

@booklet{Brown87,
   Author = {Brown, JM and Fonteno, WC and Cassel, DK and Johnson,
             GA},
   Title = {COMPUTED TOMOGRAPHIC ANALYSES OF WATER DISTRIBUTION IN THREE
             POROUS FOAM MEDIA.},
   Journal = {Soil Science Society of America Journal},
   Volume = {51},
   Number = {5},
   Pages = {1121-1125},
   Year = {1987},
   Abstract = {Computer Assisted Tomography (CAT) is commonly used in
             diagnostic radiology to make nondestructive images and
             analyses of cross sections of the human body. CAT scanning
             may also be useful in imaging and measuring spatial
             distribution and changes in water distribution in porous
             media. The purpose of this paper is to review some of the
             details of CAT scanning that are of importance to the
             application of CAT scanning to porous media and to evaluate
             the use of the CAT scanner to measure the spatial
             distribution of water in three different porous media. The
             scanner's response to changes in the spatial distribution of
             water in three different porous phenolic foam materials
             after draining for 16 h was investigated. Water content
             distributions were successfully detected with good
             resolution on the x-ray image.},
   Key = {Brown87}
}

@booklet{Fram87,
   Author = {Fram, EK and Herfkens, RJ and Johnson, GA and Glover, GH and Karis, JP and Shimakawa, A and Perkins, TG and Pelc, NJ},
   Title = {Rapid calculation of T1 using variable flip angle gradient
             refocused imaging.},
   Journal = {Magnetic Resonance Imaging},
   Volume = {5},
   Number = {3},
   Pages = {201-208},
   Year = {1987},
   ISSN = {0730-725X},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3626789},
   Abstract = {We present a method for rapid measurement of T1 relaxation
             times using gradient refocused images at limited flip angles
             and short repetition times. This "variable nutation"
             techniques was investigated using a T1 phantom. There was a
             high correlation between measurements obtained with the
             variable nutation and partial saturation techniques. The
             ability of this method to create calculated T1 images is
             also demonstrated. We conclude that the variable nutation
             method may allow measurement of T1 relaxation times with a
             significant reduction in acquisition time compared to
             partial saturation techniques.},
   Key = {Fram87}
}

@booklet{Mcadams87,
   Author = {McAdams, HP and Johnson, GA and Suddarth, SA and Sherrier, RH and Ravin,
             CE},
   Title = {IMPLEMENTATION OF ADAPTIVE FILTRATION FOR DIGITAL CHEST
             IMAGING.},
   Journal = {Optical Engineering},
   Volume = {26},
   Number = {7},
   Pages = {669-674},
   Year = {1987},
   Abstract = {Previous work has demonstrated the potential for adaptive
             filtration in processing digital chest images. The technique
             uses the histogram of the image to determine the pixels (and
             regions) in which edge enhancement is applied. This paper
             extends that work by investigating the choice of parameters
             used in selectively enhancing the mediastinum. The image is
             separated into its low and high frequency components by
             convolution with a square kernel. The effect of kernel size
             was studied with a choice of 17 multiplied by 17 mm, which
             was found to be sufficient to include the frequencies of
             interest. A serious deficiency in previous implementations
             of this technique is the existence of ringing artifacts at
             the juncture of the lung and mediastinum. These result in
             part from the use of a step function to specify the low
             frequency image intensity above which high frequencies are
             amplified. By replacing this step with a smoother (cosine)
             function, the artifact can be removed.},
   Key = {Mcadams87}
}

@booklet{Sherrier87,
   Author = {Sherrier, RH and Johnson, GA},
   Title = {Regionally adaptive histogram equalization of the
             chest.},
   Journal = {IEEE Transactions on Medical Imaging},
   Volume = {6},
   Number = {1},
   Pages = {1-7},
   Year = {1987},
   ISSN = {0278-0062},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/18230420},
   Abstract = {Advances in the area of digital chest radiography have
             resulted in the acquisition of high-quality images of the
             human chest. With these advances, there arises a genuine
             need for image processing algorithms specific to the chest,
             in order to fully exploit this digital technology. We have
             implemented the well-known technique of histogram
             equalization, noting the problems encountered when it is
             adapted to chest images. These problems have been
             successfully solved with our regionally adaptive histogram
             equalization method. With this technique histograms are
             calculated locally and then modified according to both the
             mean pixel value of that region as well as certain
             characteristics of the cumulative distribution function.
             This process, which has allowed certain regions of the chest
             radiograph to be enhanced differentially, may also have
             broader implications for other image processing
             tasks.},
   Doi = {10.1109/TMI.1987.4307791},
   Key = {Sherrier87}
}

@booklet{Johnson87c,
   Author = {JOHNSON, GA},
   Title = {RESOLUTION LIMITS IN MR - MR MICROSCOPY},
   Journal = {Medical physics},
   Volume = {14},
   Number = {3},
   Pages = {499-499},
   Year = {1987},
   ISSN = {0094-2405},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1987H776800274&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Johnson87c}
}

@booklet{Macfall87,
   Author = {MacFall, JR and Wehrli, FW and Breger, RK and Johnson,
             GA},
   Title = {Methodology for the measurement and analysis of relaxation
             times in proton imaging.},
   Journal = {Magnetic Resonance Imaging},
   Volume = {5},
   Number = {3},
   Pages = {209-220},
   Year = {1987},
   ISSN = {0730-725X},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3041152},
   Abstract = {Measurements of proton T1 and T2 were performed on GdCl3
             solutions (20 less than T2 less than 500 msec, 90 less than
             T1 less than 1000 msec) on large-bore NMR imaging systems
             operating at 1.0T and 1.5T. CPMG multi-echo (ME), multiple
             saturation recovery (MSR) and modified fast inversion
             recovery (MFIR) pulse sequences as well as a sequence that
             combines and interleaves T1 and T2 weighted data acquisition
             (which we call "multiple saturation-recovery multiple-echo"
             (MSRME) were used. The relaxation data are compared to those
             obtained on a small bore NMR spectrometer operated at 1.5T.
             T1 and T2 values for the solutions were found to be the same
             within 10% for the two fields. Reproducibility of
             measurements of T1, T2 and the unnormalized spin density of
             the solutions was better than 5%. Systematic errors,
             amenable to correction through calibration, are noted in the
             imager T1 and T2 values. T1 and T2 values for some typical
             neural tissues at 1.5T and body tissue at 1.0T for human
             volunteers were obtained and are tabulated.},
   Key = {Macfall87}
}

@article{fds292757,
   Author = {Sherrier, RH and Johnson, GA},
   Title = {REGIONALLY ADAPTIVE HISTOGRAM EQUALIZATION OF THE
             CHEST.},
   Journal = {IEEE Transactions on Medical Imaging},
   Volume = {MI-6},
   Number = {1},
   Pages = {1-7},
   Year = {1987},
   Abstract = {The authors have implemented the well-known technique of
             histogram equalization, noting the problems encountered when
             it is adapted to chest images. These problems have been
             successfully solved with a regionally adaptive histogram
             equalization method. With this technique, histograms are
             calculated locally and then modified according to both the
             mean pixel value of that region as well as certain
             characteristics of the cumulative distribution function.
             This process, which has allowed certain regions of the chest
             radiograph to be enhanced differentially, may also have
             broader implications for other image processing
             tasks.},
   Key = {fds292757}
}

@booklet{Mesfin87,
   Author = {G. M. Mesfin and G. A. Johnson and M. J. Higgins and D. F.
             Morris},
   Title = {Mechanism of anestrus in rats treated with an
             antihypertensive agent, losulazine hydrochloride},
   Journal = {Toxicology And Applied Pharmacology},
   Volume = {87},
   Number = {1},
   Pages = {91 -- 101},
   Year = {1987},
   Month = {January},
   Key = {Mesfin87}
}

@article{fds174220,
   Author = {GM Mesfin and GA Johnson and MJ Higgins and DF Morris},
   Title = {Mechanism of anestrus in rats treated with an
             antihypertensive agent, losulazine hydrochloride.},
   Journal = {Toxicology and applied pharmacology},
   Volume = {87},
   Number = {1},
   Pages = {91-101},
   Year = {1987},
   Month = {January},
   ISSN = {0041-008X},
   Keywords = {Anestrus • Animals • Antihypertensive Agents
             • Body Weight • Bromocriptine •
             Catecholamines • Dopamine • Estrus • Female
             • Follicle Stimulating Hormone • Genitalia, Female
             • Hypothalamus • Piperazines • Progesterone
             • Prolactin • Rats • Rats, Inbred Strains
             • blood • drug effects • drug effects* •
             metabolism • pharmacology • pharmacology*},
   Abstract = {The mechanism of anestrus in rats treated with losulazine, a
             peripheral sympatholytic antihypertensive agent, was
             investigated by determining its effect on hypothalamic
             catecholamines and serum sex hormones and by evaluating the
             influence of bromocriptine on the reproductive functions of
             rats treated with losulazine. Groups of six female Upjohn
             Sprague-Dawley rats were treated orally with 10 mg/kg/day of
             losulazine and/or 18.75 mg/kg/day of bromocriptine for 15 or
             27 days. Six rats were treated with losulazine plus 6.25
             mg/kg/day of bromocriptine for 16 days followed by
             losulazine alone for 11 days. Rats treated with losulazine
             only were depleted of hypothalamic catecholamines, were
             hyperprolactinemic, and had interrupted estrous cycles and
             attenuated vaginal mucosa. Treatment with bromocriptine, a
             dopamine receptor agonist, resulted in suppression of serum
             prolactin and normal estrous cycles. Rats reverted back to
             hyperprolactinemia and anestrus shortly after bromocriptine
             withdrawal. These results suggest that hyperprolactinemia
             mediated through hypothalamic dopamine depletion is the
             mechanism of anestrus in rats treated with
             losulazine.},
   Language = {eng},
   Key = {fds174220}
}

@booklet{Stude87,
   Author = {R. A. Stude and L. W. Hedlund and G. A. Johnson and W. M.
             Thompson},
   Title = {Contrast enhancement of the liver evaluation by automated
             contiguous pixel search},
   Journal = {Investigative Radiology},
   Volume = {22},
   Number = {2},
   Pages = {132 -- 136},
   Year = {1987},
   Month = {February},
   Key = {Stude87}
}

@article{fds268928,
   Author = {Stude, RA and Hedlund, LW and Johnson, GA and Thompson,
             WM},
   Title = {Contrast enhancement of the liver. Evaluation by automated
             contiguous pixel search.},
   Journal = {Investigative Radiology},
   Volume = {22},
   Number = {2},
   Pages = {132-136},
   Year = {1987},
   Month = {February},
   ISSN = {0020-9996},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3030962},
   Keywords = {Animals • Contrast Media* • Diatrizoate Meglumine
             • Dogs • Ethiodized Oil • Liver •
             Radiographic Image Enhancement* • Tomography, X-Ray
             Computed* • diagnostic use • radiography*},
   Abstract = {Eight dogs were infused with one of three different contrast
             agents: meglumine diatrizoate, iosulamide meglumine, or an
             ethiodized oil emulsion (EOE 13). Image intensity in the
             liver was evaluated globally and regionally by means of an
             automated pixel sampling method to determine differences in
             the rate of enhancement produced by the three agents. The
             results of the automated method were compared with those of
             the standard manual cursor method. The automated method
             showed that liver parenchyma was enhanced uniformly by all
             three contrast agents. The maximum degree of enhancement
             (Mean +/- SEM) for the three agents was diatrizoate, 12.0
             +/- 3.5 Hounsfield units (HU); iosluamide, 21.3 +/- 3.5 HU;
             and EOE 13, 37.2 +/- 4.25 HU. With the manual cursor method,
             contrast enhancement was about 20% more than estimated by
             the automated method. The automated method is better for
             evaluating the magnitude and pattern of contrast agent
             enhancement of the entire liver, since the currently
             employed cursor technique requires multiple evaluations to
             evaluate the entire liver.},
   Key = {fds268928}
}

@booklet{Suddarth87,
   Author = {Suddarth, SA and Johnson, GA and Sherrier, RH and Ravin,
             CE},
   Title = {Performance of high-resolution monitors for digital chest
             imaging.},
   Journal = {Medical physics},
   Volume = {14},
   Number = {2},
   Pages = {253-257},
   Year = {1987},
   Month = {March},
   ISSN = {0094-2405},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3587149},
   Abstract = {High-resolution cathode-ray tubes (CRT's) are currently the
             most viable soft-copy display for digital radiography. We
             present here methods for measuring large-area contrast ratio
             and detail contrast ratio. A two-dimensional charge coupled
             device (ccd) array signal-averaged with a video frame buffer
             permits linear microradiometric measure of individual beam
             lines. Results from three different 1000-line monitors
             demonstrate the shift variance of resolution. The detail
             contrast ratio (or modulation depth) was found to vary from
             100% to less than 10% across the face of one CRT. Dynamic
             focus in both the horizontal and vertical deflection
             circuitry proved effective in reducing this shift variance.
             Comparisons of three phosphors demonstrate the utility of
             long persistence phosphors (P164) for static display in
             producing brighter images with less flicker. Recommendations
             for CRT design and selection for high-resolution digital
             radiography are included.},
   Doi = {10.1118/1.596079},
   Key = {Suddarth87}
}

@booklet{Sherrier87a,
   Author = {Sherrier, RH and Chiles, C and Johnson, GA and Ravin,
             CE},
   Title = {Differentiation of benign from malignant pulmonary nodules
             with digitized chest radiographs.},
   Journal = {Radiology},
   Volume = {162},
   Number = {3},
   Pages = {645-649},
   Year = {1987},
   Month = {March},
   ISSN = {0033-8419},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3809476},
   Abstract = {To assess whether it is possible to distinguish benign from
             malignant solitary pulmonary nodules with digital
             techniques, a retrospective study of 68 patients with proved
             solitary nodules was performed. The conventional chest
             radiograph for each patient was digitized to 2,048 X 2,048 X
             12 bits, and changes in the optical density within the
             nodule were analyzed. A number (the corrected gradient
             number) was then generated that reflected this variation.
             Striking differences were noted between 26 malignant nodules
             and 21 calcified granulomas. The technique was then applied
             to 21 benign nodules that had initially required thoracotomy
             or further study for diagnosis. In nine of these 21 patients
             (43%), the corrected gradient number allowed correct
             classification as a benign lesion.},
   Doi = {10.1148/radiology.162.3.3809476},
   Key = {Sherrier87a}
}

@booklet{Utz87,
   Author = {UTZ, JA and HERFKENS, RJ and JOHNSON, CD and SHIMAKAWA, A and PELC, N and GLOVER, G and JOHNSON, GA and SPRITZER, CE},
   Title = {2-SECOND MR IMAGES - COMPARISON WITH SPIN-ECHO IMAGES IN 29
             PATIENTS},
   Journal = {AJR. American journal of roentgenology},
   Volume = {148},
   Number = {3},
   Pages = {629-633},
   Year = {1987},
   Month = {March},
   ISSN = {0361-803X},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1987G131300036&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Utz87}
}

@article{fds132763,
   Author = {RH Sherrier and C Chiles and GA Johnson and CE Ravin},
   Title = {Differentiation of benign from malignant pulmonary nodules
             with digitized chest radiographs.},
   Journal = {Radiology, UNITED STATES},
   Volume = {162},
   Number = {3},
   Pages = {645-9},
   Year = {1987},
   Month = {March},
   ISSN = {0033-8419},
   Keywords = {Coin Lesion, Pulmonary • Diagnosis, Differential •
             Humans • Lung Neoplasms • Radiographic Image
             Enhancement • methods* • radiography •
             radiography*},
   Abstract = {To assess whether it is possible to distinguish benign from
             malignant solitary pulmonary nodules with digital
             techniques, a retrospective study of 68 patients with proved
             solitary nodules was performed. The conventional chest
             radiograph for each patient was digitized to 2,048 X 2,048 X
             12 bits, and changes in the optical density within the
             nodule were analyzed. A number (the corrected gradient
             number) was then generated that reflected this variation.
             Striking differences were noted between 26 malignant nodules
             and 21 calcified granulomas. The technique was then applied
             to 21 benign nodules that had initially required thoracotomy
             or further study for diagnosis. In nine of these 21 patients
             (43%), the corrected gradient number allowed correct
             classification as a benign lesion.},
   Key = {fds132763}
}

@article{fds268892,
   Author = {Utz, JA and Herfkens, RJ and Johnson, CD and Shimakawa, A and Pelc, N and Glover, G and Johnson, GA and Spritzer, CE},
   Title = {Two-second MR images: comparison with spin-echo images in 29
             patients.},
   Journal = {AJR. American journal of roentgenology},
   Volume = {148},
   Number = {3},
   Pages = {629-633},
   Year = {1987},
   Month = {March},
   ISSN = {0361-803X},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3492897},
   Keywords = {Adrenal Glands • Humans • Kidney • Liver
             • Magnetic Resonance Spectroscopy • Pancreas
             • Spleen • Time Factors • diagnostic use*
             • methods • pathology},
   Abstract = {MR images can be obtained with a 2-sec scan time when an
             extremely short repetition rate (22 msec), limited flip
             angle (30 degrees), and gradient refocused echoes are used.
             Comparison of 415 such images obtained in 29 patients with
             routine T1-weighted (TR 500, TE 25) and T2-weighted (TR
             2000, TE 80) images showed that images free of respiratory
             artifacts could be obtained in all patients. Although
             abdominal organs were well seen with 2-sec scan time,
             overall evaluation of these organs was better on routine
             T1-weighted images. Vascular structures, however, were seen
             as well or better on the 2-sec images in 60% of cases. The
             images were extremely sensitive to field nonhomogeneity, and
             metallic artifact was exaggerated in five patients with
             surgical clips. Two-sec MR images provide a rapid method of
             localizing abdominal organs for further evaluation. The
             sensitivity to blood flow may assist in the assessment of
             vascular patency.},
   Doi = {10.2214/ajr.148.3.629},
   Key = {fds268892}
}

@booklet{Fiedlerweiss87,
   Author = {V. C. Fiedlerweiss and G. A. Johnson and C. M. Buys and C.
             A. Baker},
   Title = {Minoxidil sulfate and sulfotransferase activity in
             alopecia-areata},
   Journal = {Clinical Research},
   Volume = {35},
   Number = {3},
   Pages = {A682 -- A682},
   Year = {1987},
   Month = {April},
   Key = {Fiedlerweiss87}
}

@booklet{Effmann87,
   Author = {EFFMANN, EL and JOHNSON, GA and SMITH, BR and TALBOTT, GA and COFER,
             G},
   Title = {MAGNETIC-RESONANCE MICROSCOPY OF LIVE CHICK-EMBRYOS IN
             OVO},
   Journal = {Teratology},
   Volume = {35},
   Number = {2},
   Pages = {A44-A44},
   Year = {1987},
   Month = {April},
   ISSN = {0040-3709},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1987H226300076&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Effmann87}
}

@booklet{Johnson87e,
   Author = {JOHNSON, GA and THOMPSON, MB and DRAYER, BP},
   Title = {3-DIMENSIONAL MRI MICROSCOPY OF THE NORMAL
             RAT-BRAIN},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {4},
   Number = {4},
   Pages = {351-365},
   Year = {1987},
   Month = {April},
   ISSN = {0740-3194},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1987G775900005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1002/mrm.1910040406},
   Key = {Johnson87e}
}

@booklet{Neiswanger87,
   Author = {L. Neiswanger and G. A. Johnson and V. P.
             Carey},
   Title = {An experimental-study of high rayleigh number mixed
             convection in a rectangular enclosure with restricted inlet
             and outlet openings},
   Journal = {Journal Of Heat Transfer-transactions Of The
             Asme},
   Volume = {109},
   Number = {2},
   Pages = {446 -- 453},
   Year = {1987},
   Month = {May},
   Key = {Neiswanger87}
}

@booklet{Johnson87d,
   Author = {Johnson, GA and Brown, J and Kramer, PJ},
   Title = {Magnetic resonance microscopy of changes in water content in
             stems of transpiring plants.},
   Journal = {Proceedings of the National Academy of Sciences of
             USA},
   Volume = {84},
   Number = {9},
   Pages = {2752-2755},
   Year = {1987},
   Month = {May},
   ISSN = {0027-8424},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3472235},
   Abstract = {Differences in water content and degree of binding in the
             various stem tissues of Pelargonium hortorum were observed
             by magnetic resonance imaging. 1H images were obtained with
             a resolution of 100 microns in the transverse plane and a
             slice thickness of 1250 microns. It was possible to
             distinguish the principal tissues of the stem by differences
             in their proton density or apparent water content and spin
             lattice relaxation time (T1) or degree of water binding.
             Measurements were made while the plant was slowly and
             actively transpiring. In the slowly transpiring plant, T1 of
             various tissues ranged from an average of 659 to 865 ms with
             a proton density variation of from 72 to 100%. In the
             actively transpiring plant, T1 ranged from an average of 511
             to 736 ms, and the proton density was reduced, ranging
             between 62 and 88% of the peak value found in the slowly
             transpiring plant. The fibrous sheath surrounding the
             vascular tissue and the epidermal region was found to have
             the highest spin density and T1. Both tissues are comprised
             of relatively small thick-walled cells. Cortical and pith
             parenchyma are composed of larger, thinner-walled cells with
             numerous intercellular spaces and lower spin density and T1.
             The differences are attributed to the higher water content
             by volume in the tissue composed of smaller, more compactly
             arranged cells. The resolution obtained in this work enables
             clear definition of tissues in the living plant and
             quantitative information concerning differences in the
             distribution and extent of binding of water.},
   Key = {Johnson87d}
}

@article{fds132845,
   Author = {GA Johnson and J Brown and PJ Kramer},
   Title = {Magnetic resonance microscopy of changes in water content in
             stems of transpiring plants.},
   Journal = {Proceedings of the National Academy of Sciences of the
             United States of America, UNITED STATES},
   Volume = {84},
   Number = {9},
   Pages = {2752-5},
   Year = {1987},
   Month = {May},
   ISSN = {0027-8424},
   Keywords = {Magnetic Resonance Spectroscopy • Plants • Water
             • metabolism*},
   Abstract = {Differences in water content and degree of binding in the
             various stem tissues of Pelargonium hortorum were observed
             by magnetic resonance imaging. 1H images were obtained with
             a resolution of 100 microns in the transverse plane and a
             slice thickness of 1250 microns. It was possible to
             distinguish the principal tissues of the stem by differences
             in their proton density or apparent water content and spin
             lattice relaxation time (T1) or degree of water binding.
             Measurements were made while the plant was slowly and
             actively transpiring. In the slowly transpiring plant, T1 of
             various tissues ranged from an average of 659 to 865 ms with
             a proton density variation of from 72 to 100%. In the
             actively transpiring plant, T1 ranged from an average of 511
             to 736 ms, and the proton density was reduced, ranging
             between 62 and 88% of the peak value found in the slowly
             transpiring plant. The fibrous sheath surrounding the
             vascular tissue and the epidermal region was found to have
             the highest spin density and T1. Both tissues are comprised
             of relatively small thick-walled cells. Cortical and pith
             parenchyma are composed of larger, thinner-walled cells with
             numerous intercellular spaces and lower spin density and T1.
             The differences are attributed to the higher water content
             by volume in the tissue composed of smaller, more compactly
             arranged cells. The resolution obtained in this work enables
             clear definition of tissues in the living plant and
             quantitative information concerning differences in the
             distribution and extent of binding of water.},
   Key = {fds132845}
}

@booklet{Johnson87b,
   Author = {G. A. Johnson and V. J. Kapoor and P. G.
             Young},
   Title = {Plasma-deposited germanium nitride on indium-phosphide},
   Journal = {Journal Of The Electrochemical Society},
   Volume = {134},
   Number = {8B},
   Pages = {C430 -- C430},
   Year = {1987},
   Month = {August},
   Key = {Johnson87b}
}

@booklet{Kamperschroer87,
   Author = {J. H. Kamperschroer and H. W. Kugel and M. A. Reale and S.
             L. Hayes and G. A. Johnson and J. L. Lowrance and P. A. Shah and P. Sichta and B. W. Sleaford and M. D. Williams and P.
             M. Zucchino},
   Title = {Multiple track doppler-shift spectroscopy system for tftr
             neutral beam injectors},
   Journal = {Review Of Scientific Instruments},
   Volume = {58},
   Number = {8},
   Pages = {1362 -- 1368},
   Year = {1987},
   Month = {August},
   Key = {Kamperschroer87}
}

@booklet{Johnson87a,
   Author = {G. A. Johnson},
   Title = {Cbn wheel grinding},
   Journal = {Journal Of Metals},
   Volume = {39},
   Number = {9},
   Pages = {62 -- 63},
   Year = {1987},
   Month = {September},
   Key = {Johnson87a}
}

@booklet{Hedlund87,
   Author = {HEDLUND, L and COFER, G and SUDDARTH, S and JOHNSON,
             GA},
   Title = {SMALL ANIMAL ANESTHESIA AND MONITORING DURING EXTENDED MR
             MICROSCOPY},
   Journal = {Investigative Radiology},
   Volume = {22},
   Number = {9},
   Pages = {S44-S44},
   Year = {1987},
   Month = {September},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1987K178300189&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198709000-00193},
   Key = {Hedlund87}
}

@booklet{Brown87a,
   Author = {BROWN, JM and KRAMER, PJ and COFER, GP and JOHNSON,
             GA},
   Title = {MAGNETIC-RESONANCE-IMAGING OF ROOT-WATER
             DISTRIBUTION},
   Journal = {HortScience : a publication of the American Society for
             Horticultural Science},
   Volume = {22},
   Number = {5},
   Pages = {1087-1087},
   Year = {1987},
   Month = {October},
   ISSN = {0018-5345},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1987K430400370&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Brown87a}
}

@booklet{Drayer87,
   Author = {Drayer, BP and Burger, P and Hurwitz, B and Dawson, D and Cain, J and Leong, J and Herfkens, R and Johnson, GA},
   Title = {Magnetic resonance imaging in multiple sclerosis: decreased
             signal in thalamus and putamen.},
   Journal = {Annals of Neurology},
   Volume = {22},
   Number = {4},
   Pages = {546-550},
   Year = {1987},
   Month = {October},
   ISSN = {0364-5134},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3435073},
   Abstract = {High-field strength (1.5 Tesla) magnetic resonance imaging
             in 15 patients with multiple and extensive white-matter
             lesions and clinically definite multiple sclerosis
             delineated a previously undescribed finding of abnormally
             decreased signal intensity on T2-weighted images in the
             thalamus and putamen. The decreased signal intensity
             (preferential decreased T2 relaxation time) is most likely
             to be related to abnormally increased iron accumulation
             causing local magnetic field heterogeneities.},
   Doi = {10.1002/ana.410220418},
   Key = {Drayer87}
}

@article{fds132879,
   Author = {BP Drayer and P Burger and B Hurwitz and D Dawson and J Cain and J Leong and R
             Herfkens, GA Johnson},
   Title = {Magnetic resonance imaging in multiple sclerosis: decreased
             signal in thalamus and putamen.},
   Journal = {Annals of neurology, UNITED STATES},
   Volume = {22},
   Number = {4},
   Pages = {546-50},
   Year = {1987},
   Month = {October},
   ISSN = {0364-5134},
   Keywords = {Humans • Magnetic Resonance Imaging* • Multiple
             Sclerosis • Putamen • Thalamus • diagnosis*
             • pathology*},
   Abstract = {High-field strength (1.5 Tesla) magnetic resonance imaging
             in 15 patients with multiple and extensive white-matter
             lesions and clinically definite multiple sclerosis
             delineated a previously undescribed finding of abnormally
             decreased signal intensity on T2-weighted images in the
             thalamus and putamen. The decreased signal intensity
             (preferential decreased T2 relaxation time) is most likely
             to be related to abnormally increased iron accumulation
             causing local magnetic field heterogeneities.},
   Key = {fds132879}
}

@booklet{Johnson87,
   Author = {G. A. Johnson and C. A. Baker},
   Title = {Sulfation of minoxidil by human-platelet
             sulfotransferase},
   Journal = {Clinica Chimica Acta},
   Volume = {169},
   Number = {2-3},
   Pages = {217 -- 227},
   Year = {1987},
   Month = {November},
   Key = {Johnson87}
}

@article{fds132848,
   Author = {GA Johnson and CA Baker},
   Title = {Sulfation of minoxidil by human platelet
             sulfotransferase.},
   Journal = {Clinica chimica acta; international journal of clinical
             chemistry, NETHERLANDS},
   Volume = {169},
   Number = {2-3},
   Pages = {217-27},
   Year = {1987},
   Month = {November},
   ISSN = {0009-8981},
   Keywords = {Adolescent • Adult • Arylsulfotransferase •
             Blood Platelets • Chromatography, High Pressure Liquid
             • Humans • Hydrogen-Ion Concentration • Male
             • Middle Aged • Minoxidil • Platelet Count
             • Sulfurtransferases • blood* • enzymology*
             • metabolism*},
   Abstract = {In an attempt to determine whether (1) sulfotransferase
             activity in human platelets would convert minoxidil to
             minoxidil sulfate and (2) inter-subject variations in this
             sulfotransferase activity could be noted, platelet
             homogenates were incubated with minoxidil and 35S-PAPS in
             HEPES buffer at 37 degrees C for 30 min. Radioactivity which
             was extracted into ethyl acetate and shown by HPLC to elute
             with authentic minoxidil sulfate was counted by
             scintillation counting. Aliquots of the platelet homogenates
             were also preincubated at 43 degrees C for 15 min to
             determine the thermal stability of the sulfotransferase
             activity. Sulfotransferase activity in platelets from 48
             adult males ranged from 0.9-13.2 pmol minoxidil sulfate
             produced/10(7) platelets per 30 min (mean 4.91 +/- 2.84
             pmol/10(7) platelets per 30 min +/- SD). Thermal stable
             sulfotransferase activity ranged from 0.2-7.6 pmol minoxidil
             produced/10(7) platelets per 30 min and varied from 15 to
             57% of the total sulfotransferase activity. Thus, the
             results indicate that human platelets can effect the
             sulfation of minoxidil and that sulfotransferase activity
             does show inter-subject variation.},
   Key = {fds132848}
}

@booklet{Hollett87,
   Author = {Hollett, MD and Cofer, GP and Johnson, GA},
   Title = {In situ magnetic resonance microscopy.},
   Journal = {Investigative Radiology},
   Volume = {22},
   Number = {12},
   Pages = {965-968},
   Year = {1987},
   Month = {December},
   ISSN = {0020-9996},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3440731},
   Abstract = {Recent developments in MR permit imaging at microscopic
             resolution. Efforts have focused on small samples that fit
             entirely in the imaging probe. Extension of the techniques
             to imaging of individual organs in small animals is
             complicated by both the need to acquire an excessive number
             of phase encodings and limited signal to noise. Implantable
             radiofrequency coils described in this work eliminate both
             problems, permitting MR microscopy in the kidney of a live
             200-g rat with spatial resolution of 117 X 117 X 1250 mu
             (.02 mm3). Inductive coupling permits complete freedom from
             external leads. A phantom designed to evaluate dielectric
             losses is described. Both phantom and in vivo comparison of
             live kidney images demonstrate the tenfold improvement in
             signal to noise obtained with the implantable
             coil.},
   Key = {Hollett87}
}

@article{fds132776,
   Author = {MD Hollett and GP Cofer and GA Johnson},
   Title = {In situ magnetic resonance microscopy.},
   Journal = {Investigative radiology, UNITED STATES},
   Volume = {22},
   Number = {12},
   Pages = {965-8},
   Year = {1987},
   Month = {December},
   ISSN = {0020-9996},
   Keywords = {Animals • Kidney • Magnetic Resonance Imaging
             • Models, Structural • Rats • anatomy &
             histology* • methods*},
   Abstract = {Recent developments in MR permit imaging at microscopic
             resolution. Efforts have focused on small samples that fit
             entirely in the imaging probe. Extension of the techniques
             to imaging of individual organs in small animals is
             complicated by both the need to acquire an excessive number
             of phase encodings and limited signal to noise. Implantable
             radiofrequency coils described in this work eliminate both
             problems, permitting MR microscopy in the kidney of a live
             200-g rat with spatial resolution of 117 X 117 X 1250 mu
             (.02 mm3). Inductive coupling permits complete freedom from
             external leads. A phantom designed to evaluate dielectric
             losses is described. Both phantom and in vivo comparison of
             live kidney images demonstrate the tenfold improvement in
             signal to noise obtained with the implantable
             coil.},
   Key = {fds132776}
}

@article{fds132761,
   Author = {D Dixon and GA Johnson and GP Cofer and LW Hedlund and RR
             Maronpot},
   Title = {Magnetic resonance imaging (MRI): a new tool in experimental
             toxicologic pathology.},
   Journal = {Toxicologic pathology, UNITED STATES},
   Volume = {16},
   Number = {3},
   Pages = {386-91},
   Year = {1988},
   ISSN = {0192-6233},
   Keywords = {Animals • Magnetic Resonance Imaging* • Pathology*
             • Rats • Toxicology*},
   Abstract = {Magnetic Resonance Imaging (MRI) is a noninvasive imaging
             technique that provides multidimensional images of the soft
             tissues of the body. This imaging technique has proven to be
             an excellent diagnostic and experimental tool for the
             detection of pathologic alterations in soft tissues, as well
             as an adjunct screening method for following the genesis,
             progression, or regression of chemically induced lesions in
             the same live animal. Future applications of MRI technology
             in small animals include MRI microscopy, mapping of vascular
             or circulatory alterations, measurement of perfusion and
             diffusion rates of body fluids, and acquisition of cell
             metabolic states in combination with Nuclear Magnetic
             Resonance (NMR) spectroscopy, all of which will contribute
             immensely to the advancement of toxicologic and biomolecular
             research.},
   Key = {fds132761}
}

@article{fds174135,
   Author = {BM Markaverich and RR Roberts and MA Alejandro and GA Johnson and BS
             Middleditch, JH Clark},
   Title = {Bioflavonoid interaction with rat uterine type II binding
             sites and cell growth inhibition.},
   Journal = {Journal of steroid biochemistry},
   Volume = {30},
   Number = {1-6},
   Pages = {71-8},
   Year = {1988},
   ISSN = {0022-4731},
   Keywords = {Animals • Binding, Competitive • Breast Neoplasms
             • Cell Division • Cell Line • Cell Nucleus
             • Cytosol • Female • Flavonoids • Humans
             • Kinetics • Rats • Receptors, Estradiol
             • Receptors, Estrogen • Uterus • cytology
             • drug effects • metabolism • metabolism*
             • pharmacology*},
   Abstract = {Competition analysis with a number of known bioflavonoids
             demonstrated that these compounds (luteolin, quercetin,
             pelargonin) compete for [3H]estradiol binding to cytosol and
             nuclear type II sites in rat uterine preparations. The
             inhibition of [3H]estradiol binding to type II sites was
             specific and these bioflavonoids did not interact with the
             rat uterine estrogen receptor. Since estradiol stimulation
             of nuclear type II sites in the rat uterus is highly
             correlated with cellular hypertrophy and hyperplasia, we
             assessed the effects of these compounds on the growth of
             MCF-7 human breast cancer cells in culture and on estradiol
             stimulation of uterine growth in the immature rat. The data
             demonstrated that addition of quercetin (5-10 micrograms/ml)
             to MCF-7 cell cultures resulted in a dose-dependent
             inhibition of cell growth (DNA/flask). This effect was
             reversible by removal of quercetin from the culture medium,
             or by the addition of 10 nM estradiol-17 beta to these cell
             cultures containing this bioflavonoid. Since estradiol-17
             beta (10 nM) stimulated nuclear type II sites and
             proliferation of MCF-7 cells, we believe bioflavonoid
             inhibition of MCF-7 cell growth may be mediated through an
             interaction with nuclear type II sites. This hypothesis was
             confirmed by in vivo studies which demonstrated that
             injection of luteolin or quercetin blocked estradiol
             stimulation of nuclear type II sites in the immature rat
             uterus and this correlated with an inhibition of uterine
             growth (wet and dry weight). These studies suggest
             bioflavonoids, through an interaction with type II sites,
             may be involved in cell growth regulation.},
   Language = {eng},
   Key = {fds174135}
}

@article{fds268797,
   Author = {Dixon, D and Johnson, GA and Cofer, GP and Hedlund, LW and Maronpot,
             RR},
   Title = {Magnetic resonance imaging (MRI): A new tool in experimental
             toxicologic pathology},
   Journal = {Toxicologic Pathology},
   Volume = {16},
   Number = {3},
   Pages = {387-391},
   Year = {1988},
   Abstract = {Magnetic Resonance Imaging (MRI) is a noninvasive imaging
             technique that provides multidimensional images of the soft
             tissues of the body. This imaging technique has proven to be
             an excellent diagnostic and experimental tool for the
             detection of pathologic alterations in soft tissues, as well
             as an adjunct screening method for following the genesis,
             progression, or regression of chemically induced lesions in
             the same live animal. Future applications of MRI technology
             in small animals include MRI microscopy, mapping of vascular
             or circulatory alterations, measurement of perfusion and
             diffusion rates of body fluids, and acquisition of cell
             metabolic states in combination with Nuclear Magnetic
             Resonance (NMR) spectroscopy, all of which will contribute
             immensely to the advancement of toxicologic and biomolecular
             research.},
   Key = {fds268797}
}

@booklet{Maki88,
   Author = {Maki, JH and Johnson, GA and Cofer, GP and MacFall,
             JR},
   Title = {SNR improvement in NMR microscopy using DEFT},
   Journal = {Journal of Magnetic Resonance (1969)},
   Volume = {80},
   Number = {3},
   Pages = {482-492},
   Year = {1988},
   ISSN = {0022-2364},
   url = {http://dx.doi.org/10.1016/0022-2364(88)90243-0},
   Abstract = {This paper examines the use of a driven equilibrium Fourier
             transform (DEFT) pulse sequence for improving the signal per
             unit time and hence image resolution in NMR microscopy. DEFT
             vs partial saturation (PS) is modeled and it is shown that
             DEFT is most useful in physiologic materials provided short
             TE values (TE ≪ T2) and short TR values (TR < T1) are
             used. Under these conditions, DEFT can yield up to a
             fourfold signal increase compared to PS. It is shown that
             DEFT can provide spin density and T1/T2-ratio-weighted
             images. DEFT is also shown to have SNR advantages as T1
             increases-an important consideration at higher magnetic
             fields. Experimental data that verify the theoretical
             predictions and the functioning of a DEFT pulse sequence to
             produce high-quality 2D spin-warp images of a phantom are
             presented. Studies performed on small animals demonstrate
             the utility of the DEFT sequence in MR microscopy by
             providing increased SNR and new contrast mechanisms over
             limited fields of view. © 1988.},
   Doi = {10.1016/0022-2364(88)90243-0},
   Key = {Maki88}
}

@booklet{Dixon88,
   Author = {Dixon, D and Johnson, GA and Cofer, GP and Hedlund, LW and Maronpot,
             RR},
   Title = {Magnetic resonance imaging (MRI): a new tool in experimental
             toxicologic pathology.},
   Journal = {Toxicologic Pathology (Sage)},
   Volume = {16},
   Number = {3},
   Pages = {386-391},
   Year = {1988},
   ISSN = {0192-6233},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3194661},
   Abstract = {Magnetic Resonance Imaging (MRI) is a noninvasive imaging
             technique that provides multidimensional images of the soft
             tissues of the body. This imaging technique has proven to be
             an excellent diagnostic and experimental tool for the
             detection of pathologic alterations in soft tissues, as well
             as an adjunct screening method for following the genesis,
             progression, or regression of chemically induced lesions in
             the same live animal. Future applications of MRI technology
             in small animals include MRI microscopy, mapping of vascular
             or circulatory alterations, measurement of perfusion and
             diffusion rates of body fluids, and acquisition of cell
             metabolic states in combination with Nuclear Magnetic
             Resonance (NMR) spectroscopy, all of which will contribute
             immensely to the advancement of toxicologic and biomolecular
             research.},
   Doi = {10.1177/019262338801600311},
   Key = {Dixon88}
}

@booklet{Markaverich88a,
   Author = {B. M. Markaverich and R. R. Roberts and M. A. Alejandro and G. A. Johnson and B. S. Middleditch and J. H.
             Clark},
   Title = {Bioflavonoid interaction with rat uterine type-ii
             binding-sites and cell-growth inhibition},
   Journal = {Journal Of Steroid Biochemistry And Molecular
             Biology},
   Volume = {30},
   Number = {1-6},
   Pages = {71 -- 78},
   Year = {1988},
   Key = {Markaverich88a}
}

@article{fds132771,
   Author = {WE Conner and GA Johnson and GP Cofer and K Dittrich},
   Title = {Magnetic resonance microscopy: in vivo sectioning of a
             developing insect.},
   Journal = {Experientia, SWITZERLAND},
   Volume = {44},
   Number = {1},
   Pages = {11-2},
   Year = {1988},
   Month = {January},
   ISSN = {0014-4754},
   Keywords = {Animals • Female • Lepidoptera • Magnetic
             Resonance Imaging* • Microscopy • Moths •
             Pupa • anatomy & histology • anatomy & histology*
             • growth & development},
   Abstract = {The utility of magnetic resonance imaging vis-a-vis insect
             morphology and development was investigated. MRI is a
             noninvasive technique that distinguishes between tissues
             based on proton content and proton 'environment'. At present
             a resolution of 100 micron is achievable. The technique
             avoids fixation artifacts and allows the detection of motion
             within the organism.},
   Key = {fds132771}
}

@booklet{Conner88,
   Author = {Conner, WE and Johnson, GA and Cofer, GP and Dittrich,
             K},
   Title = {Magnetic resonance microscopy: in vivo sectioning of a
             developing insect.},
   Journal = {Experientia},
   Volume = {44},
   Number = {1},
   Pages = {11-12},
   Year = {1988},
   Month = {January},
   ISSN = {0014-4754},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3350110},
   Abstract = {The utility of magnetic resonance imaging vis-a-vis insect
             morphology and development was investigated. MRI is a
             noninvasive technique that distinguishes between tissues
             based on proton content and proton 'environment'. At present
             a resolution of 100 micron is achievable. The technique
             avoids fixation artifacts and allows the detection of motion
             within the organism.},
   Key = {Conner88}
}

@booklet{Sherrier88a,
   Author = {Sherrier, RH and Chiles, C and Wilkinson, WE and Johnson, GA and Ravin,
             CE},
   Title = {Effects of image processing on nodule detection rates in
             digitized chest radiographs: ROC study of observer
             performance.},
   Journal = {Radiology},
   Volume = {166},
   Number = {2},
   Pages = {447-450},
   Year = {1988},
   Month = {February},
   ISSN = {0033-8419},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3336719},
   Abstract = {To evaluate the effects of image processing in digitized
             chest radiographs when high-resolution images are used, an
             examination was done in which the detection of pulmonary
             nodules in unprocessed digitized chest radiographs was
             compared with that in images that had undergone processing
             with two methods, adaptive filtration and histogram
             equalization. The processing techniques have been optimized
             in previous work to selectively enhance the retrocardiac and
             subdiaphragmatic areas without significant alteration of
             detail in the lung. Eight observers were shown 150 test
             radiographs (50 unprocessed, 50 processed with adaptive
             filtration, 50 processed with histogram equalization)
             containing 150 nodules. The results indicate a statistically
             significant (P less than .03) difference, with highest
             observer performance in the chest radiographs processed with
             adaptive filtration (median area under ROC curve = 0.78),
             compared with unprocessed images (median = 0.68) and chest
             radiographs processed with histogram equalization (median =
             0.62). Performance in the lung was not significantly
             different. Adaptive filtration applied to selectively
             enhance underexposed areas of film images may improve nodule
             detection. Histogram equalization provided no improvement in
             performance.},
   Doi = {10.1148/radiology.166.2.3336719},
   Key = {Sherrier88a}
}

@article{fds132873,
   Author = {RH Sherrier and C Chiles and WE Wilkinson and GA Johnson and CE
             Ravin},
   Title = {Effects of image processing on nodule detection rates in
             digitized chest radiographs: ROC study of observer
             performance.},
   Journal = {Radiology, UNITED STATES},
   Volume = {166},
   Number = {2},
   Pages = {447-50},
   Year = {1988},
   Month = {February},
   ISSN = {0033-8419},
   Keywords = {Coin Lesion, Pulmonary • Filtration • Humans
             • Lung Neoplasms • ROC Curve* • Radiographic
             Image Enhancement • methods • methods* •
             radiography*},
   Abstract = {To evaluate the effects of image processing in digitized
             chest radiographs when high-resolution images are used, an
             examination was done in which the detection of pulmonary
             nodules in unprocessed digitized chest radiographs was
             compared with that in images that had undergone processing
             with two methods, adaptive filtration and histogram
             equalization. The processing techniques have been optimized
             in previous work to selectively enhance the retrocardiac and
             subdiaphragmatic areas without significant alteration of
             detail in the lung. Eight observers were shown 150 test
             radiographs (50 unprocessed, 50 processed with adaptive
             filtration, 50 processed with histogram equalization)
             containing 150 nodules. The results indicate a statistically
             significant (P less than .03) difference, with highest
             observer performance in the chest radiographs processed with
             adaptive filtration (median area under ROC curve = 0.78),
             compared with unprocessed images (median = 0.68) and chest
             radiographs processed with histogram equalization (median =
             0.62). Performance in the lung was not significantly
             different. Adaptive filtration applied to selectively
             enhance underexposed areas of film images may improve nodule
             detection. Histogram equalization provided no improvement in
             performance.},
   Key = {fds132873}
}

@booklet{Tenbrink88,
   Author = {R. E. Tenbrink and D. T. Pals and D. W. Harris and G. A.
             Johnson},
   Title = {Renin inhibitors containing psi-[ch2o] pseudopeptide
             inserts},
   Journal = {Journal Of Medicinal Chemistry},
   Volume = {31},
   Number = {3},
   Pages = {671 -- 677},
   Year = {1988},
   Month = {March},
   Key = {Tenbrink88}
}

@booklet{Spritzer88,
   Author = {Spritzer, CE and Vogler, JB and Martinez, S and Garrett, WE and Johnson,
             GA and McNamara, MJ and Lohnes, J and Herfkens, RJ},
   Title = {MR imaging of the knee: preliminary results with a 3DFT
             GRASS pulse sequence.},
   Journal = {AJR. American journal of roentgenology},
   Volume = {150},
   Number = {3},
   Pages = {597-603},
   Year = {1988},
   Month = {March},
   ISSN = {0361-803X},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3257617},
   Abstract = {The knees of 17 patients (18 extremities) with possible
             meniscal, cruciate ligament, and articular cartilage
             abnormalities were examined with a three-dimensional Fourier
             transform (3DFT), gradient-refocused acquisition in a steady
             state (GRASS) pulse sequence. Arthroscopic confirmation was
             available in all cases and was the standard for comparison.
             Thirteen of these extremities were also examined by using a
             two-dimensional Fourier transform spin-echo pulse sequence
             with a 2000-msec repetition time and 20- and 80-msec echo
             time. In these 13 cases, both pulse sequences correctly
             identified seven of eight meniscal abnormalities. However,
             interpretation of the 3DFT GRASS images resulted in fewer
             false-positive meniscal tears (three vs six). Cruciate
             ligament tears were detected more readily on the 3DFT GRASS
             images (six vs three with two possible tears on the
             spin-echo images). These preliminary findings suggest that
             the overall accuracy of MR imaging of the knee could be
             improved by including 3DFT gradient-refocused pulse
             sequences.},
   Doi = {10.2214/ajr.150.3.597},
   Key = {Spritzer88}
}

@article{fds132757,
   Author = {CE Spritzer and JB Vogler and S Martinez and WE Garrett and GA Johnson and MJ McNamara and J Lohnes and RJ Herfkens},
   Title = {MR imaging of the knee: preliminary results with a 3DFT
             GRASS pulse sequence.},
   Journal = {AJR. American journal of roentgenology, UNITED
             STATES},
   Volume = {150},
   Number = {3},
   Pages = {597-603},
   Year = {1988},
   Month = {March},
   ISSN = {0361-803X},
   Keywords = {Adolescent • Adult • Arthroscopy • Female
             • Humans • Joint Diseases • Knee Injuries
             • Knee Joint • Magnetic Resonance Imaging* •
             Male • Middle Aged • anatomy & histology •
             diagnosis • methods • pathology*},
   Abstract = {The knees of 17 patients (18 extremities) with possible
             meniscal, cruciate ligament, and articular cartilage
             abnormalities were examined with a three-dimensional Fourier
             transform (3DFT), gradient-refocused acquisition in a steady
             state (GRASS) pulse sequence. Arthroscopic confirmation was
             available in all cases and was the standard for comparison.
             Thirteen of these extremities were also examined by using a
             two-dimensional Fourier transform spin-echo pulse sequence
             with a 2000-msec repetition time and 20- and 80-msec echo
             time. In these 13 cases, both pulse sequences correctly
             identified seven of eight meniscal abnormalities. However,
             interpretation of the 3DFT GRASS images resulted in fewer
             false-positive meniscal tears (three vs six). Cruciate
             ligament tears were detected more readily on the 3DFT GRASS
             images (six vs three with two possible tears on the
             spin-echo images). These preliminary findings suggest that
             the overall accuracy of MR imaging of the knee could be
             improved by including 3DFT gradient-refocused pulse
             sequences.},
   Key = {fds132757}
}

@article{fds174116,
   Author = {RE TenBrink and DT Pals and DW Harris and GA Johnson},
   Title = {Renin inhibitors containing psi[CH2O] pseudopeptide
             inserts.},
   Journal = {Journal of medicinal chemistry},
   Volume = {31},
   Number = {3},
   Pages = {671-7},
   Year = {1988},
   Month = {March},
   ISSN = {0022-2623},
   Keywords = {Amino Acid Sequence • Angiotensinogen • Chemistry,
             Physical • Humans • Molecular Sequence Data •
             Physicochemical Phenomena • Renin •
             Structure-Activity Relationship • analogs &
             derivatives* • antagonists & inhibitors* •
             chemical synthesis • pharmacology},
   Abstract = {Renin inhibitors 2-4 with the D-Lys renin inhibitory peptide
             (RIP) sequence, but containing Leu psi[CH2O]Ala (2), Leu
             psi[CH2O]Val (3), and Leu psi[CH2O]Leu (4) at the P1-P1'
             site, were of a comparable potency to RIP. N-Terminal
             Boc-protected inhibitors containing Pro psi[CH2O]Phe in
             positions P4-P3 were potent inhibitors of renin, with
             Boc-Phe-Pro psi[CH2O]Phe-His-Leu psi[CH(OH)CH2]Val-Ile-(2-aminomethyl)
             pyridine (17) having an IC50 of 1.6 X 10(-9)
             M.},
   Language = {eng},
   Key = {fds174116}
}

@booklet{Markaverich88b,
   Author = {B. M. Markaverich and R. R. Gregory and M. A. Alejandro and J. H. Clark and G. A. Johnson and B. S. Middleditch},
   Title = {Methyl para-hydroxyphenyllactate - an inhibitor of
             cell-growth and proliferation and an endogenous ligand for
             nuclear type-ii binding-sites},
   Journal = {Journal Of Biological Chemistry},
   Volume = {263},
   Number = {15},
   Pages = {7203 -- 7210},
   Year = {1988},
   Month = {May},
   Key = {Markaverich88b}
}

@article{fds174147,
   Author = {BM Markaverich and RR Gregory and MA Alejandro and JH Clark and GA
             Johnson, BS Middleditch},
   Title = {Methyl p-hydroxyphenyllactate. An inhibitor of cell growth
             and proliferation and an endogenous ligand for nuclear
             type-II binding sites.},
   Journal = {The Journal of biological chemistry},
   Volume = {263},
   Number = {15},
   Pages = {7203-10},
   Year = {1988},
   Month = {May},
   ISSN = {0021-9258},
   Keywords = {Animals • Breast Neoplasms • Cell Division •
             Cell Line • Cell Nucleus • Chromatography, Gel
             • Chromatography, High Pressure Liquid • Female
             • Humans • Lactates • Mass Spectrometry
             • Ovariectomy • Rats • Rats, Inbred Strains
             • Receptors, Estradiol • Receptors, Estrogen
             • drug effects* • isolation & purification •
             metabolism • metabolism* • pharmacology*},
   Abstract = {We previously described and partially characterized
             endogenous ligands for nuclear type II sites in normal and
             malignant tissues. Chromatography of these ligands on
             Sephadex LH-20 revealed that two peaks with binding activity
             (alpha and beta) could be resolved. The beta-peak component
             was present in all normal tissues that we examined, but not
             in malignant tissues, and it inhibited the growth of MCF-7
             human breast cancer cells in vitro. Conversely, the
             alpha-peak component was found to be present in both normal
             and malignant tissues, and did not inhibit MCF-7 cell
             growth. The present studies describe the purification and
             identification of the alpha-peak and beta-peak components in
             bovine serum and an assessment of the effects of these
             compounds on normal and malignant cell growth. Gas
             chromatography-mass spectroscopy analysis of the purified
             beta-peak component demonstrated that the compound was
             methyl p-hydroxyphenyllactate (MeHPLA). Competition analysis
             revealed that MeHPLA binds to nuclear type II sites with a
             high binding affinity, while physiological levels of this
             compound blocked estradiol stimulation of uterine growth in
             vivo and inhibited the growth of MCF-7 human breast cancer
             cells in vitro. The alpha-peak component was found to be the
             corresponding acid, p-hydroxyphenyllactic acid (HPLA). This
             compound interacted with nuclear type II sites with a
             relatively low affinity and did not block uterotropic
             response to estradiol or inhibit MCF-7 cell growth. These
             studies demonstrate that HPLA and MeHPLA are ligands for
             nuclear type II sites and that MeHPLA may be a very
             important regulator of normal and malignant cell
             growth.},
   Language = {eng},
   Key = {fds174147}
}

@booklet{Effmann88,
   Author = {Effmann, EL and Johnson, GA and Smith, BR and Talbott, GA and Cofer,
             G},
   Title = {Magnetic resonance microscopy of chick embryos in
             ovo.},
   Journal = {Teratology},
   Volume = {38},
   Number = {1},
   Pages = {59-65},
   Year = {1988},
   Month = {July},
   ISSN = {0040-3709},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/3175940},
   Abstract = {Magnetic resonance imaging (MRI) of the live 11-day chick
             embryo with special radiofrequency coils and 3-D imaging
             methods has produced contiguous 1.25-mm-thick slices with
             200-microns pixel resolution, permitting definition of
             cardiac chambers, cerebral ventricles, spinal cord, liver,
             and lungs. It was the objective of this study to image
             younger chick embryos in ovo with higher spatial resolution
             through the application of implanted radiofrequency coils.
             Fertilized Arbor Acre eggs were windowed at 9, 6, and 4
             days. Circular coils 18 mm in diameter tuned to 85.5 MHz
             were suspended around the developing embryo. The eggs were
             sealed with tape and maintained at 37 degrees C during the
             imaging procedure. MRI was performed in a 2.0-Tesla GE
             system utilizing a 3-D Fourier transform acquisition in
             sagittal and axial planes with a partial saturation sequence
             (TR = 400 ms, TE = 27 ms). Approximately 1 hour of imaging
             time was required to obtain 16 contiguous 600-microns-thick
             slices with 50-microns pixel resolution. Embryos remained
             viable through the imaging procedure. Embryos were
             photographed, fixed, and cleared for correlative anatomical
             study. Vitelline vessels, dorsal aorta, aortic arches,
             cardinal veins, and cardiac chambers were identified as
             areas of decreased signal intensity. Cerebral ventricles and
             the vitreous portion of the eye have signal intensities that
             are less than adjacent neural, scleral, and lens tissue.
             Further refinements in MR instrumentation and imaging
             sequences promise improvements in resolution and offer the
             potential for sequential observations of the intact
             embryo.},
   Doi = {10.1002/tera.1420380109},
   Key = {Effmann88}
}

@article{fds132781,
   Author = {EL Effmann and GA Johnson and BR Smith and GA Talbott and G
             Cofer},
   Title = {Magnetic resonance microscopy of chick embryos in
             ovo.},
   Journal = {Teratology, UNITED STATES},
   Volume = {38},
   Number = {1},
   Pages = {59-65},
   Year = {1988},
   Month = {July},
   ISSN = {0040-3709},
   Keywords = {Animals • Cardiovascular System • Chick Embryo
             • Magnetic Resonance Imaging • Nervous System
             • anatomy & histology* • embryology •
             methods*},
   Abstract = {Magnetic resonance imaging (MRI) of the live 11-day chick
             embryo with special radiofrequency coils and 3-D imaging
             methods has produced contiguous 1.25-mm-thick slices with
             200-microns pixel resolution, permitting definition of
             cardiac chambers, cerebral ventricles, spinal cord, liver,
             and lungs. It was the objective of this study to image
             younger chick embryos in ovo with higher spatial resolution
             through the application of implanted radiofrequency coils.
             Fertilized Arbor Acre eggs were windowed at 9, 6, and 4
             days. Circular coils 18 mm in diameter tuned to 85.5 MHz
             were suspended around the developing embryo. The eggs were
             sealed with tape and maintained at 37 degrees C during the
             imaging procedure. MRI was performed in a 2.0-Tesla GE
             system utilizing a 3-D Fourier transform acquisition in
             sagittal and axial planes with a partial saturation sequence
             (TR = 400 ms, TE = 27 ms). Approximately 1 hour of imaging
             time was required to obtain 16 contiguous 600-microns-thick
             slices with 50-microns pixel resolution. Embryos remained
             viable through the imaging procedure. Embryos were
             photographed, fixed, and cleared for correlative anatomical
             study. Vitelline vessels, dorsal aorta, aortic arches,
             cardinal veins, and cardiac chambers were identified as
             areas of decreased signal intensity. Cerebral ventricles and
             the vitreous portion of the eye have signal intensities that
             are less than adjacent neural, scleral, and lens tissue.
             Further refinements in MR instrumentation and imaging
             sequences promise improvements in resolution and offer the
             potential for sequential observations of the intact
             embryo.},
   Key = {fds132781}
}

@booklet{Markaverich88,
   Author = {B. M. Markaverich and R. R. Gregory and M. A. Alejandro and G. A. Johnson and B. S. Middleditch},
   Title = {Methyl para-hydroxyphenyllactate - identification in
             rat-liver extracts},
   Journal = {Journal Of High Resolution Chromatography \& Chromatography
             Communications},
   Volume = {11},
   Number = {8},
   Pages = {605 -- 607},
   Year = {1988},
   Month = {August},
   Key = {Markaverich88}
}

@booklet{Sherrier88,
   Author = {SHERRIER, RH and SUDDARTH, SA and JOHNSON, GA},
   Title = {FILM-BASED DIGITAL TOMOSYNTHESIS OF THE CHEST},
   Journal = {Optical Engineering},
   Volume = {27},
   Number = {8},
   Pages = {691-695},
   Year = {1988},
   Month = {August},
   ISSN = {0091-3286},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1988P713200014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1117/12.7976742},
   Key = {Sherrier88}
}

@booklet{Grist88,
   Author = {T. M. Grist and J. S. Hyde and A. Jesmanowicz and G. A.
             Johnson},
   Title = {Quadrature detection local coils for mri and
             mrs},
   Journal = {Investigative Radiology},
   Volume = {23},
   Number = {9},
   Pages = {S21 -- S21},
   Year = {1988},
   Month = {September},
   Key = {Grist88}
}

@booklet{Maki88a,
   Author = {MAKI, JH and COFER, GP and HEDLUND, LW and MACFALL, JR and JOHNSON,
             GA},
   Title = {MR MICROSCOPY USING DRIVEN EQUILIBRIUM (DEFT)},
   Journal = {Investigative Radiology},
   Volume = {23},
   Number = {9},
   Pages = {S21-S21},
   Year = {1988},
   Month = {September},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1988Q574500093&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Maki88a}
}

@booklet{Brown88,
   Author = {BROWN, JM and THOMAS, JF and COFER, GP and JOHNSON,
             GA},
   Title = {MAGNETIC-RESONANCE MICROSCOPY OF STEM TISSUES OF PELARGONIUM
             HORTORUM},
   Journal = {Botanical Gazette},
   Volume = {149},
   Number = {3},
   Pages = {253-259},
   Year = {1988},
   Month = {September},
   ISSN = {0006-8071},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1988Q941300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1086/337713},
   Key = {Brown88}
}

@booklet{Maynor88,
   Author = {MAYNOR, CH and CHARLES, HC and HERFKENS, RJ and SUDDARTH, SA and JOHNSON, GA},
   Title = {INVITRO CHEMICAL-SHIFT IMAGING OF ATHEROSCLEROSIS AT
             7.0-TESLA},
   Journal = {Investigative Radiology},
   Volume = {23},
   Number = {9},
   Pages = {S3-S3},
   Year = {1988},
   Month = {September},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1988Q574500021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Maynor88}
}

@booklet{Farmer88,
   Author = {FARMER, THR and JOHNSON, GA and COFER, GP and MARONPOT, RR and HEDLUND,
             LW},
   Title = {MR MICROSCOPY OF NEPHROTOXIC ACUTE TUBULAR-NECROSIS IN THE
             RAT},
   Journal = {Investigative Radiology},
   Volume = {23},
   Number = {9},
   Pages = {S10-S10},
   Year = {1988},
   Month = {September},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1988Q574500048&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Farmer88}
}

@booklet{Dockery88,
   Author = {DOCKERY, S and SUDDARTH, SA and COFER, GP and JOHNSON,
             GA},
   Title = {THE IMPACT OF INCREASED SPIN-LATTICE RELAXATION-TIME
             MICROSCOPY AT 7.0T},
   Journal = {Investigative Radiology},
   Volume = {23},
   Number = {9},
   Pages = {S20-S20},
   Year = {1988},
   Month = {September},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1988Q574500089&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Dockery88}
}

@booklet{Stern88,
   Author = {STERN, RL and CLINE, HE and JOHNSON, GA and RAVIN,
             CE},
   Title = {DEVELOPMENT OF A 3D RECONSTRUCTED-IMAGE SURGICAL PLANNING
             STATION},
   Journal = {Investigative Radiology},
   Volume = {23},
   Number = {9},
   Pages = {S60-S60},
   Year = {1988},
   Month = {September},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1988Q574500240&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Stern88}
}

@article{fds174149,
   Author = {GA Johnson and TK Hung and AM Brant and HS Borovetz},
   Title = {Experimental determination of wall shear rate in canine
             carotid arteries perfused in vitro.},
   Journal = {Journal of biomechanics},
   Volume = {22},
   Number = {11-12},
   Pages = {1141-50},
   Year = {1989},
   ISSN = {0021-9290},
   Keywords = {Animals • Biomechanics • Carotid Arteries •
             Dogs • Endothelium, Vascular • Hemodynamics •
             Lipoproteins, LDL • Mathematical Computing •
             Models, Cardiovascular • metabolism • physiology*
             • physiopathology},
   Abstract = {The mathematical model of Hung (Tsai and Hung, 1984) is
             employed to determine the wall shear rate acting on canine
             carotid arteries perfused in vitro. Model equations for
             pulsatile flow in a deformable vessel are coupled with
             experimental data of dynamic pressure drop, flow rate,
             vessel radius and radial wall motion. Derived quantities,
             e.g. velocity profiles and wall shear, are obtained for
             vessels exposed to 'normotensive' hemodynamics,
             'hypertension' simulations and perfusions in which the
             compliance of the vessel wall is deliberately altered. Our
             results indicate that wall shear varies markedly as a
             function of the hemodynamic environment. The effects of
             vessel radius vs flow rate on the development of wall shear
             are also demonstrated. It is found that convective processes
             correlate with the magnitude of wall shear in the
             'hypertension' simulations. The present findings and
             complementary published data may explain, at least in part,
             the variations in vessel wall transport and endothelial cell
             biology we observe as a function of the hemodynamic
             environment. For example we have documented that the
             exposure of canine carotids to 'hypertensive' (vs
             'normotensive') hemodynamics is associated with an increased
             flux of lipoproteins (LDL) into the intima and luminal
             media. Alternations in wall compliance, on the other hand,
             profoundly influence endothelial shape, orientation and
             cytoskeletal array.},
   Language = {eng},
   Key = {fds174149}
}

@booklet{Cofer89,
   Author = {Cofer, GP and Brown, JM and Johnson, GA},
   Title = {In vivo magnetic resonance microscopy at 5
             μm},
   Journal = {Journal of Magnetic Resonance (1969)},
   Volume = {83},
   Number = {3},
   Pages = {608-616},
   Year = {1989},
   ISSN = {0022-2364},
   url = {http://dx.doi.org/10.1016/0022-2364(89)90354-5},
   Doi = {10.1016/0022-2364(89)90354-5},
   Key = {Cofer89}
}

@article{fds268758,
   Author = {Johnson, GA and Maronpont, RR},
   Title = {Magnetic resonance microscopy of chemically-induced liver
             foci},
   Journal = {Toxicologic Pathology (Sage)},
   Volume = {17},
   Number = {4 I},
   Pages = {613-616},
   Year = {1989},
   ISSN = {0192-6233},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/2629098},
   Keywords = {Animals • Carcinogenicity Tests • Diet •
             Female • Liver • Liver Neoplasms, Experimental
             • Magnetic Resonance Imaging • Rats • Rats,
             Inbred F344 • chemically induced • pathology*
             • ultrastructure},
   Abstract = {Magnetic resonance imaging (MRI) is a new imaging technique
             used in clinical diagnosis. This paper describes extension
             of the technique to basic research applications -
             specifically detecting and characterizing chemically-induced
             liver neoplasms and foci of cellular alteration. Two systems
             have been built that allow spatial microscopic resolution -
             more than 100,000x greater than that of earlier efforts. Use
             of spin-lattice (T1) and spin-spin (T2) relaxation times
             permits detailed characterization of the
             tissue.},
   Doi = {10.1177/0192623389017004106},
   Key = {fds268758}
}

@booklet{Johnson89,
   Author = {G. A. Johnson and T. K. Hung and A. M. Brant and H. S.
             Borovetz},
   Title = {Experimental-determination of wall shear rate in canine
             carotid arteries perfused invitro},
   Journal = {Journal Of Biomechanics},
   Volume = {22},
   Number = {11-12},
   Pages = {1141 -- 1150},
   Year = {1989},
   Key = {Johnson89}
}

@booklet{Steadman89,
   Author = {L. E. Steadman and G. A. Johnson and E. L. Belden and W. J.
             Murdoch},
   Title = {Decline in sialic-acid composition of cellular membranes
             isolated from ovine corpora-lutea during
             prostaglandin-induced luteolysis - apparent independence of
             autoimmune recognition},
   Journal = {American Journal Of Reproductive Immunology},
   Volume = {19},
   Number = {1},
   Pages = {1 -- 2},
   Year = {1989},
   Month = {January},
   Key = {Steadman89}
}

@booklet{Maynor89,
   Author = {Maynor, CH and Charles, HC and Herfkens, RJ and Suddarth, SA and Johnson, GA},
   Title = {Chemical shift imaging of atherosclerosis at 7.0
             Tesla.},
   Journal = {Investigative Radiology},
   Volume = {24},
   Number = {1},
   Pages = {52-60},
   Year = {1989},
   Month = {January},
   ISSN = {0020-9996},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/2917823},
   Abstract = {Chemical shift imaging (CSI) was performed on cadaveric
             atherosclerotic fibrous plaques, periaortic adipose tissue,
             and cholesterol standards using a 7.0 Tesla horizontal bore
             prototype imaging spectrometer. Proton spectroscopy of
             intact tissue and deuterated chloroform extracted samples
             was done at the equivalent field strength of 7.0 Tesla on a
             vertical bore spectrometer, including studies of temperature
             dependence and T2 relaxation measurements. Spectra obtained
             using CSI on the imaging magnet were comparable with those
             from the conventional vertical spectrometer. Fibrous plaques
             and adipose tissue had unique spectral features, differing
             in the ratios of their water and various fat components.
             Chloroform extractions revealed a typical cholesteric ester
             spectrum for the fibrous plaque in contrast to the
             triglyceride spectrum of the adipose tissue. These two
             tissues also had different T2 relaxation measurements of
             their major fat resonances, with fibrous plaques having a
             short T2 compared to adipose tissue (15.9 milliseconds vs.
             46.2 milliseconds). Temperature dependence studies showed
             that spectral signal intensity of the fat resonance of the
             fibrous plaque increased while linewidth decreased with
             increasing temperature from 24 degrees C to 37 degrees C.
             Atherosclerotic lesions may be studied at 7.0 Tesla, and NMR
             parameters defined in the present study may be used for
             further studies at other magnetic field strengths.},
   Key = {Maynor89}
}

@booklet{Cline89,
   Author = {Cline, HE and Lorensen, WE and Herfkens, RJ and Johnson, GA and Glover,
             GH},
   Title = {Vascular morphology by three-dimensional magnetic resonance
             imaging.},
   Journal = {Magnetic Resonance Imaging},
   Volume = {7},
   Number = {1},
   Pages = {45-54},
   Year = {1989},
   Month = {January},
   ISSN = {0730-725X},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/2918818},
   Abstract = {A three-dimensional examination of blood vessels is provided
             using MR data from seven cases. The vascular surfaces are
             constructed with an algorithm that automatically follows the
             selected artery or vein and generates a projected
             three-dimensional gradient shaded image. Fast 3DFT pulse
             sequences were optimized to enhance the time-of-flight
             contrast of the intravascular region. By increasing the
             surface threshold value in a three-dimensional head study,
             the flesh of a patient's face was peeled away to demonstrate
             the superfacial temporal artery. Gated cardiac images show
             the great vessels and cardiac chambers. A three-dimensional
             view of the aorta shows an irregular surface in the vicinity
             of an adrenal tumor. 3D MR exams provide a non-invasive
             technique for assessing vascular morphology in a clinical
             setting.},
   Key = {Cline89}
}

@booklet{Matyac89,
   Author = {Matyac, CA and Cofer, GP and Bailey, JE and Johnson,
             GA},
   Title = {In Situ Observations of Root-gall Formation Using Nuclear
             Magnetic Resonance Imaging.},
   Journal = {Journal of nematology},
   Volume = {21},
   Number = {1},
   Pages = {131-134},
   Year = {1989},
   Month = {January},
   ISSN = {0022-300X},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/19287587},
   Key = {Matyac89}
}

@article{fds132789,
   Author = {CH Maynor and HC Charles and RJ Herfkens and SA Suddarth and GA
             Johnson},
   Title = {Chemical shift imaging of atherosclerosis at 7.0
             Tesla.},
   Journal = {Investigative radiology, UNITED STATES},
   Volume = {24},
   Number = {1},
   Pages = {52-60},
   Year = {1989},
   Month = {January},
   ISSN = {0020-9996},
   Keywords = {Adipose Tissue • Aged • Aorta • Aortic
             Diseases • Arteriosclerosis • Cholesterol Esters
             • Female • Humans • Magnetic Resonance
             Spectroscopy • Male • Middle Aged •
             Triglycerides • diagnostic use* • metabolism
             • pathology • pathology*},
   Abstract = {Chemical shift imaging (CSI) was performed on cadaveric
             atherosclerotic fibrous plaques, periaortic adipose tissue,
             and cholesterol standards using a 7.0 Tesla horizontal bore
             prototype imaging spectrometer. Proton spectroscopy of
             intact tissue and deuterated chloroform extracted samples
             was done at the equivalent field strength of 7.0 Tesla on a
             vertical bore spectrometer, including studies of temperature
             dependence and T2 relaxation measurements. Spectra obtained
             using CSI on the imaging magnet were comparable with those
             from the conventional vertical spectrometer. Fibrous plaques
             and adipose tissue had unique spectral features, differing
             in the ratios of their water and various fat components.
             Chloroform extractions revealed a typical cholesteric ester
             spectrum for the fibrous plaque in contrast to the
             triglyceride spectrum of the adipose tissue. These two
             tissues also had different T2 relaxation measurements of
             their major fat resonances, with fibrous plaques having a
             short T2 compared to adipose tissue (15.9 milliseconds vs.
             46.2 milliseconds). Temperature dependence studies showed
             that spectral signal intensity of the fat resonance of the
             fibrous plaque increased while linewidth decreased with
             increasing temperature from 24 degrees C to 37 degrees C.
             Atherosclerotic lesions may be studied at 7.0 Tesla, and NMR
             parameters defined in the present study may be used for
             further studies at other magnetic field strengths.},
   Key = {fds132789}
}

@article{fds174140,
   Author = {CA Matyac and GP Cofer and JE Bailey and GA Johnson},
   Title = {In Situ Observations of Root-gall Formation Using Nuclear
             Magnetic Resonance Imaging.},
   Journal = {Journal of nematology},
   Volume = {21},
   Number = {1},
   Pages = {131-4},
   Year = {1989},
   Month = {January},
   ISSN = {0022-300X},
   Language = {eng},
   Key = {fds174140}
}

@article{fds174292,
   Author = {LE Steadman and GA Johnson and EL Belden and WJ Murdoch},
   Title = {Decline in sialic acid composition of cellular membranes
             isolated from ovine corpora lutea during
             prostaglandin-induced luteolysis: apparent independence of
             autoimmune recognition.},
   Journal = {American journal of reproductive immunology (New York, N.Y.
             : 1989)},
   Volume = {19},
   Number = {1},
   Pages = {1-2},
   Year = {1989},
   Month = {January},
   ISSN = {1046-7408},
   Keywords = {Animals • Autoantibodies • Cell Membrane •
             Corpus Luteum • Dinoprost • Female •
             N-Acetylneuraminic Acid • Sheep • Sialic Acids
             • analysis • analysis* • drug effects •
             pharmacology* • physiology*},
   Abstract = {Sialic acid was quantified in plasma membranes of corpora
             lutea isolated during prostaglandin (PG) F2 alpha-induced
             luteolysis in sheep. Concentrations of sialic acid within
             membranes decreased after injection of PGF2 alpha, and
             before signs of luteal regression (i.e., a decline in tissue
             concentrations of progesterone) were manifested. Removal of
             residues of sialic acid from luteal membranes was not
             associated with cellular binding of gamma globulin, as
             monitored by indirect immunofluorescence microscopy. We
             suggest that desialylation of luteal membranes could be an
             important aspect of the mechanism of luteolysis. Such a
             process does not appear to involve participation of
             autoantibody.},
   Language = {eng},
   Key = {fds174292}
}

@booklet{Buhl89a,
   Author = {A. E. Buhl and T. T. Kawabe and D. J. Waldon and K. A.
             Knight and G. A. Johnson and C. J. Walker and A. R.
             Diani},
   Title = {Pigmentation affects the distribution of mnx in
             hair-follicles but does not influence its
             activity},
   Journal = {Journal Of Investigative Dermatology},
   Volume = {92},
   Number = {3},
   Pages = {409 -- 409},
   Year = {1989},
   Month = {March},
   Key = {Buhl89a}
}

@booklet{Waldon89a,
   Author = {D. J. Waldon and A. E. Buhl and C. A. Baker and G. A.
             Johnson},
   Title = {Is minoxidil sulfate the active metabolite for
             hair-growth},
   Journal = {Journal Of Investigative Dermatology},
   Volume = {92},
   Number = {3},
   Pages = {538 -- 538},
   Year = {1989},
   Month = {March},
   Key = {Waldon89a}
}

@booklet{Buhl89,
   Author = {A. E. Buhl and T. T. Kawabe and D. J. Waldon and K. A.
             Knight and G. A. Johnson and C. J. Walker and A. R.
             Diani},
   Title = {Pigmentation affects the distribution of mnx in
             hair-follicles but does not influence its
             activity},
   Journal = {Clinical Research},
   Volume = {37},
   Number = {2},
   Pages = {A745 -- A745},
   Year = {1989},
   Month = {April},
   Key = {Buhl89}
}

@booklet{Waldon89,
   Author = {D. J. Waldon and A. E. Buhl and C. A. Baker and G. A.
             Johnson},
   Title = {Is minoxidil sulfate the active metabolite for
             hair-growth},
   Journal = {Clinical Research},
   Volume = {37},
   Number = {2},
   Pages = {A769 -- A769},
   Year = {1989},
   Month = {April},
   Key = {Waldon89}
}

@booklet{Stern89,
   Author = {STERN, RL and CLINE, HE and JOHNSON, GA and RAVIN,
             CE},
   Title = {3-DIMENSIONAL IMAGING OF THE THORACIC CAVITY},
   Journal = {Investigative Radiology},
   Volume = {24},
   Number = {4},
   Pages = {282-288},
   Year = {1989},
   Month = {April},
   ISSN = {0020-9996},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1989U232200004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1097/00004424-198904000-00005},
   Key = {Stern89}
}

@article{fds268896,
   Author = {Stern, RL and Cline, HE and Johnson, GA and Ravin,
             CE},
   Title = {Three-dimensional imaging of the thoracic
             cavity.},
   Journal = {Investigative Radiology},
   Volume = {24},
   Number = {4},
   Pages = {282-288},
   Year = {1989},
   Month = {April},
   ISSN = {0020-9996},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/2745007},
   Keywords = {Humans • Image Processing, Computer-Assisted •
             Radiography, Thoracic • Tomography, X-Ray Computed*
             • methods*},
   Abstract = {Three-dimensional (3D) surface reconstruction techniques
             were applied to sets of computed tomographic (CT) images of
             the thoracic cavity. Emphasis was placed on extracting lung
             images. High quality, detailed 3D images of the lung surface
             and internal bronchial and vascular structures were
             produced.},
   Key = {fds268896}
}

@booklet{Farmer89,
   Author = {T. H. R. Farmer and G. A. Johnson and G. P. Cofer and R. R.
             Maronpot and D. Dixon and L. W. Hedlund},
   Title = {Implanted coil mr microscopy of renal pathology},
   Journal = {Magnetic Resonance In Medicine},
   Volume = {10},
   Number = {3},
   Pages = {310 -- 323},
   Year = {1989},
   Month = {June},
   Key = {Farmer89}
}

@article{fds132809,
   Author = {GW Baxter and RP Behringer and T Fagert and GA Johnson},
   Title = {Pattern formation in flowing sand.},
   Journal = {Phys Rev Lett},
   Volume = {62},
   Number = {24},
   Pages = {2825-2828},
   Year = {1989},
   Month = {June},
   ISSN = {0031-9007},
   Key = {fds132809}
}

@article{fds269011,
   Author = {Farmer, TH and Johnson, GA and Cofer, GP and Maronpot, RR and Dixon, D and Hedlund, LW},
   Title = {Implanted coil MR microscopy of renal pathology.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {10},
   Number = {3},
   Pages = {310-323},
   Year = {1989},
   Month = {June},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/2733588},
   Keywords = {Animals • Electrodes, Implanted • Kidney •
             Kidney Diseases • Magnetic Resonance Imaging •
             Microscopy • Rats • Rats, Inbred Strains •
             chemically induced • metabolism • methods* •
             pathology*},
   Abstract = {Inductively coupled implanted coils have been shown to
             provide up to a 10-fold increase in signal-to-noise ratio
             when compared to whole-body imaging of small animals. The
             current study was designed to extend the implanted coil
             imaging technique to a rodent model of renal pathology.
             Resonant radiofrequency (RF) coils were implanted around the
             left kidney of four rats and inductively coupled from within
             a birdcage body coil. All images were acquired at 2 T using
             a T1-weighted spin-echo sequence with TR = 500 ms and TE =
             20 ms. In vivo MR microscopy with voxels of 117 x 117 x 2000
             microns demonstrated cortex, inner and outer medulla, and
             major vascular structures on baseline images. Mercuric
             chloride-induced nephrotoxic acute tubular necrosis (ATN)
             diminished cortico-medullary contrast at 24 h after dosing
             with pathologic evaluation demonstrating nephrotoxic changes
             in the inner cortex. The kidney regained a baseline MR
             appearance 360 h after dosing and resolution of the damage
             was confirmed with histology. T1 data were gathered on
             excised kidneys as an adjunct to the images to help
             correlate the loss and return of cortico-medullary contrast
             with the pathology and pathophysiology of nephrotoxic ATN.
             With implanted RF coils we were able to demonstrate renal
             pathology and follow its subsequent resolution.
             Specifically, loss and return of cortico-medullary contrast
             as a result of nephrotoxic ATN were serially documented in
             four rats. Such serial in vivo studies performed on single
             animals should further the use of MR microscopy by
             minimizing the number of animals required for adequate
             biostatistics.},
   Key = {fds269011}
}

@booklet{Baxter89,
   Author = {Baxter, GW and Behringer, RP and Fagert, T and Johnson,
             GA},
   Title = {Pattern formation in flowing sand.},
   Journal = {Physical Review Letters},
   Volume = {62},
   Number = {24},
   Pages = {2825-2828},
   Year = {1989},
   Month = {June},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10040101},
   Doi = {10.1103/PhysRevLett.62.2825},
   Key = {Baxter89}
}

@booklet{Johnson89a,
   Author = {Johnson, GA and Thompson, MB and Cofer, GP and Campen, D and Maronpot,
             RR},
   Title = {Magnetic resonance imaging of hepatic neoplasms in the
             rat.},
   Journal = {Veterinary pathology},
   Volume = {26},
   Number = {4},
   Pages = {303-308},
   Year = {1989},
   Month = {July},
   ISSN = {0300-9858},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/2763419},
   Abstract = {Magnetic resonance imaging (MRI) at microscopic resolution
             was done on a live rat that had chemically induced hepatic
             neoplasms. Beginning at the anterior aspect of the liver, 16
             contiguous transaxial slices (each 1.25 mm thick) were
             produced using three-dimensional Fourier transform
             sequences. The rat had been treated with diethylnitrosamine
             (200 mg/kg) at 70 days of age, and, subsequently, received
             periodic implants of 17a-ethynylestradiol for 60 weeks.
             Carr-Purcell-Meiboom-Gill (CPMG) sequences (repetition time
             = 2,000 and echo time = 20, 40, 60, 80 ms) were done to give
             quantitative measures of spin-spin relaxation times (T2).
             Pixel-by-pixel curve fitting from these multiple images
             yielded calculated T2 images. Histologic evaluation of three
             abnormal areas in the liver revealed solid and cystic
             hepatocellular adenomas. Although lesions were evident in
             early-echo images of the CPMG sequence, they were more
             apparent in the late-echo images. This was consistent with
             longer T2 relaxation times for the lesions. The voxels of
             dimensions (230 x 230 x 1,250 microns) permitted resolution
             of volume elements less than 0.07 mm3. This in turn
             permitted clear delineation of focal lesions less than 3 mm
             in diameter. The potential for MRI at microscopic resolution
             in toxicologic research is clearly demonstrated.},
   Doi = {10.1177/030098588902600403},
   Key = {Johnson89a}
}

@article{fds132815,
   Author = {GA Johnson and MB Thompson and GP Cofer and D Campen and RR
             Maronpot},
   Title = {Magnetic resonance imaging of hepatic neoplasms in the
             rat.},
   Journal = {Veterinary pathology, UNITED STATES},
   Volume = {26},
   Number = {4},
   Pages = {303-8},
   Year = {1989},
   Month = {July},
   ISSN = {0300-9858},
   Keywords = {Animals • Female • Liver Neoplasms, Experimental
             • Magnetic Resonance Imaging* • Ovariectomy •
             Rats • Rats, Inbred Strains • diagnosis •
             pathology* • veterinary},
   Abstract = {Magnetic resonance imaging (MRI) at microscopic resolution
             was done on a live rat that had chemically induced hepatic
             neoplasms. Beginning at the anterior aspect of the liver, 16
             contiguous transaxial slices (each 1.25 mm thick) were
             produced using three-dimensional Fourier transform
             sequences. The rat had been treated with diethylnitrosamine
             (200 mg/kg) at 70 days of age, and, subsequently, received
             periodic implants of 17a-ethynylestradiol for 60 weeks.
             Carr-Purcell-Meiboom-Gill (CPMG) sequences (repetition time
             = 2,000 and echo time = 20, 40, 60, 80 ms) were done to give
             quantitative measures of spin-spin relaxation times (T2).
             Pixel-by-pixel curve fitting from these multiple images
             yielded calculated T2 images. Histologic evaluation of three
             abnormal areas in the liver revealed solid and cystic
             hepatocellular adenomas. Although lesions were evident in
             early-echo images of the CPMG sequence, they were more
             apparent in the late-echo images. This was consistent with
             longer T2 relaxation times for the lesions. The voxels of
             dimensions (230 x 230 x 1,250 microns) permitted resolution
             of volume elements less than 0.07 mm3. This in turn
             permitted clear delineation of focal lesions less than 3 mm
             in diameter. The potential for MRI at microscopic resolution
             in toxicologic research is clearly demonstrated.},
   Key = {fds132815}
}

@booklet{Dockery89,
   Author = {Dockery, SE and Suddarth, SA and Johnson, GA},
   Title = {Relaxation measurements at 300 MHz using MR
             microscopy.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {11},
   Number = {2},
   Pages = {182-192},
   Year = {1989},
   Month = {August},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/2779411},
   Abstract = {Previous data on changes in tissue T1 with field have
             suggested the convergence of tissue T1 values toward a
             common value at high (greater than 4.0 T) fields. Measures
             of T2 dependence have suggested reduction of T2 with field.
             The purpose of this study was to observe the T1 and T2 at
             85.5 and 300 MHz of microstructures in excised rat kidneys
             by employing MR microscopy. This study represents the first
             attempt of MR microscopy at 7.0 T with regard to the subject
             of magnetic field dependence of T1 and T2. As expected, T1
             did increase with increasing field strength but not as
             dramatically as might be expected. Subtle differences in the
             microstructures of the kidney and the binding of water in
             those structures were discernible on the basis of T1
             differences at 300 MHz. T2 values decreased, raising
             speculation concerning the mechanism for this dependence.
             The improved SNR permits smaller samples to be examined at
             much higher resolutions (greater than 30 X 30 X 200
             microns), further extending the potentials for MR
             microscopy.},
   Key = {Dockery89}
}

@article{fds132850,
   Author = {SE Dockery and SA Suddarth and GA Johnson},
   Title = {Relaxation measurements at 300 MHz using MR
             microscopy.},
   Journal = {Magnetic resonance in medicine : official journal of the
             Society of Magnetic Resonance in Medicine / Society of
             Magnetic Resonance in Medicine, UNITED STATES},
   Volume = {11},
   Number = {2},
   Pages = {182-92},
   Year = {1989},
   Month = {August},
   ISSN = {0740-3194},
   Keywords = {Animals • Kidney • Magnetic Resonance Imaging*
             • Microscopy • Rats • Rats, Inbred F344
             • anatomy & histology • methods},
   Abstract = {Previous data on changes in tissue T1 with field have
             suggested the convergence of tissue T1 values toward a
             common value at high (greater than 4.0 T) fields. Measures
             of T2 dependence have suggested reduction of T2 with field.
             The purpose of this study was to observe the T1 and T2 at
             85.5 and 300 MHz of microstructures in excised rat kidneys
             by employing MR microscopy. This study represents the first
             attempt of MR microscopy at 7.0 T with regard to the subject
             of magnetic field dependence of T1 and T2. As expected, T1
             did increase with increasing field strength but not as
             dramatically as might be expected. Subtle differences in the
             microstructures of the kidney and the binding of water in
             those structures were discernible on the basis of T1
             differences at 300 MHz. T2 values decreased, raising
             speculation concerning the mechanism for this dependence.
             The improved SNR permits smaller samples to be examined at
             much higher resolutions (greater than 30 X 30 X 200
             microns), further extending the potentials for MR
             microscopy.},
   Key = {fds132850}
}

@booklet{Miyoshi89,
   Author = {K. Miyoshi and J. J. Pouch and S. A. Alterovitz and D. M.
             Pantic and G. A. Johnson},
   Title = {Adhesion, friction, and wear of plasma-deposited thin
             silicon-nitride films at temperatures to
             700-degrees-c},
   Journal = {Wear},
   Volume = {133},
   Number = {1},
   Pages = {107 -- 123},
   Year = {1989},
   Month = {September},
   Key = {Miyoshi89}
}

@booklet{Cserhati89,
   Author = {A. F. Cserhati and V. K. Lucian and E. K. Austin and G. A.
             Johnson and P. D. Sarmiento and G. A. West and C.
             Magee},
   Title = {Impurity content, redistribution and interface topography in
             poly and amorphous-silicon based cobalt polycides},
   Journal = {Applied Surface Science},
   Volume = {38},
   Number = {1-4},
   Pages = {195 -- 195},
   Year = {1989},
   Month = {September},
   Key = {Cserhati89}
}

@booklet{Middleditch89,
   Author = {B. S. Middleditch and G. A. Johnson and R. R. Gregory and M.
             A. Alejandro and B. M. Markaverich},
   Title = {Gingerol analysis without artifact formation},
   Journal = {Hrc-journal Of High Resolution Chromatography},
   Volume = {12},
   Number = {10},
   Pages = {677 -- 679},
   Year = {1989},
   Month = {October},
   Key = {Middleditch89}
}

@booklet{Markaverich89,
   Author = {B. M. Markaverich and R. R. Gregory and M. A. Alejandro and R. S. Varma and G. A. Johnson and B. S. Middleditch},
   Title = {Estrogen regulation of methyl para-hydroxyphenylactate
             hydrolysis - correlation with estrogen stimulation of rat
             uterine growth},
   Journal = {Journal Of Steroid Biochemistry And Molecular
             Biology},
   Volume = {33},
   Number = {5},
   Pages = {867 -- 876},
   Year = {1989},
   Month = {November},
   Key = {Markaverich89}
}

@booklet{Kamperschroer89,
   Author = {J. H. Kamperschroer and L. R. Grisham and L. E. Dudek and G.
             M. Gammel and G. A. Johnson and H. W. Kugel and L. Lagin and T. E. Oconnor and P. A. Shah and P. Sichta and T. N.
             Stevenson and A. Vonhalle and M. D. Williams and R.
             Bastasz},
   Title = {Tftr neutral beam injected power measurement},
   Journal = {Review Of Scientific Instruments},
   Volume = {60},
   Number = {11},
   Pages = {3377 -- 3385},
   Year = {1989},
   Month = {November},
   Key = {Kamperschroer89}
}

@article{fds174255,
   Author = {BM Markaverich and RR Gregory and MA Alejandro and RS Varma and GA
             Johnson, BS Middleditch},
   Title = {Estrogen regulation of methyl p-hydroxyphenyllactate
             hydrolysis: correlation with estrogen stimulation of rat
             uterine growth.},
   Journal = {Journal of steroid biochemistry},
   Volume = {33},
   Number = {5},
   Pages = {867-76},
   Year = {1989},
   Month = {November},
   ISSN = {0022-4731},
   Keywords = {Animals • Cell Compartmentation • Chromatography
             • Cytosol • Esterases • Estrogens •
             Female • Hot Temperature • Kinetics •
             Lactates • Phenylpropionates • Rats •
             Substrate Specificity • Uterus • enzymology*
             • metabolism • metabolism* •
             physiology*},
   Abstract = {We have recently demonstrated that methyl
             p-hydroxyphenyllactate (MeHPLA) is the endogenous ligand for
             nuclear type II binding sites in the rat uterus and other
             estrogen target and non-target tissues. MeHPLA binds to
             nuclear type II binding sites with a very high binding
             affinity (Kd approximately 4-5 nM), blocks uterine growth in
             vivo, and inhibits MCF-7 human breast cancer cell growth in
             vitro. Conversely, the free acid (p-hydroxyphenyllactic
             acid, HPLA) interacts with type II binding sites with a much
             lower affinity (Kd approximately 200 nM) and does not
             inhibit estrogen-induced uterine growth in vivo or MCF-7
             cell growth in vitro. On the basis of these observations, we
             suggested that one way that estrogen may override MeHPLA
             inhibition of rat uterine growth may be to stimulate
             esterase hydrolysis of MeHPLA to HPLA. The present studies
             demonstrate that the rat uterus does contain an esterase
             (mol. wt approximately 50,000) which cleaves MeHPLA to HPLA,
             and that this enzyme is under estrogen regulation. This
             conclusion is supported by the observations that MeHPLA
             esterase activity is increased 2-3-fold above controls
             within 2-4 h following a single injection of estradiol, and
             is maintained at high levels for 16-24 h following hormone
             administration. This sustained elevation of MeHPLA esterase
             activity correlates with estradiol stimulation of true
             uterine growth and DNA synthesis.},
   Language = {eng},
   Key = {fds174255}
}

@article{fds268888,
   Author = {Sherrier, RH and Chotas, HG and Johnson, GA and Chiles, C and Ravin,
             CE},
   Title = {Image optimization in a computed-radiography/photostimulable-phosphor
             system.},
   Journal = {Journal of Digital Imaging},
   Volume = {2},
   Number = {4},
   Pages = {212-219},
   Year = {1989},
   Month = {November},
   ISSN = {0897-1889},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/2488166},
   Keywords = {Humans • Image Processing, Computer-Assisted* •
             Radiography, Thoracic • Tomography, X-Ray Computed*
             • X-Ray Film},
   Abstract = {Photostimulable phosphor imaging is an exciting new
             technology that has several advantages over film/screen
             radiography, the most important of which is the linearity of
             the photostimulable phosphor system over a wide exposure
             latitude. The photostimulable phosphor image is digital, and
             as such, provides options of how the image is viewed by
             radiologists. This report discusses the various
             image-processing parameters available for a photostimulable
             phosphor system and describes a rational approach for
             selecting these parameters in portable chest radiography. As
             photostimulable phosphor imaging becomes more widely
             implemented, an understanding of the processing parameters
             will facilitate the production of images that take full
             advantage of the benefits of these systems.},
   Key = {fds268888}
}

@article{fds132801,
   Author = {RL Stern and GA Johnson and CE Ravin},
   Title = {Magnetic resonance imaging of the thoracic cavity using a
             paused 3DFT acquisition technique.},
   Journal = {Magnetic resonance imaging, UNITED STATES},
   Volume = {8},
   Number = {6},
   Pages = {747-53},
   Year = {1990},
   ISSN = {0730-725X},
   Keywords = {Animals • Dogs • Humans • Magnetic Resonance
             Imaging • Thorax • anatomy & histology* •
             methods*},
   Abstract = {A new pulse sequence designed for magnetic resonance imaging
             of the entire thoracic cavity is described. This sequence,
             called 3DPAUSE, is a rapid three-dimensional Fourier
             transform (3DFT) sequences with periodic pauses for
             breathing and additional rf pulses after each pause to
             restore the magnetization to steady-state before data
             acquisition resumes. Cardiac motion artifacts are
             effectively removed by signal averaging. Respiratory motion
             artifacts are removed by breath hold. Image artifacts caused
             by an inadequate number of pauses or by inappropriate
             placement of the pauses within a scan are shown, and ways to
             avoid these artifacts are discussed. 3DPAUSE provides the
             ability to acquire three-dimensional arrays in the thoracic
             cavity with minimal artifacts from respiratory and cardiac
             motions in a clinically reasonable time.},
   Key = {fds132801}
}

@article{fds268759,
   Author = {MacFall, JR and Benveniste, H and Maki, J and Johnson, GA and Hedlund,
             L and Copher, G},
   Title = {MR diffusion measurements in stroke models in rat
             brains},
   Journal = {Proceedings of the Annual Conference on Engineering in
             Medicine and Biology},
   Number = {pt 1},
   Pages = {67-68},
   Year = {1990},
   Abstract = {It is shown that tissue self-diffusion coefficients can be
             calculated from a series of diffusion-weighted MR (magnetic
             resonance) images. By variation of the time between
             diffusion sensitizing gradient pulses, the motions of tissue
             water may be characterized on varying length scales from 10
             μm to 100 μm. Typically, the diffusion coefficient
             decreases as this diffusion time increases. Such
             characterization of tissue water properties may be of use in
             the study of the course of pathology in disease
             models.},
   Key = {fds268759}
}

@article{fds268760,
   Author = {Johnson, GA and Chotas, HG and Suddarth, SA and Ziv, SB and Todd,
             BE},
   Title = {Integrated network for medical imaging research},
   Journal = {Proceedings of SPIE - The International Society for Optical
             Engineering},
   Volume = {1234 pt 1},
   Pages = {159-166},
   Year = {1990},
   Abstract = {There are a number of generic problems that researchers in
             medical imaging have in common. For example, researchers in
             MR, CT, PET, SPECT, DSA, and digital radiography all need to
             display and window digital images. We describe here an
             integrated with tools applicable to all of the current areas
             of medical imaging that enable researchers at Duke to share
             resources and solve software and hardware problems in a
             unified effort. We will show examples where efforts in a
             specific area of imaging research can be readily applied in
             new ways to different imaging modalities through the
             facilities provided in this integrated approach. We will
             point out some of the problems and opportunities in the
             research environment that are different from those
             encountered in clinical PACS system.},
   Key = {fds268760}
}

@booklet{Brown90,
   Author = {Brown, JM and Kramer, PJ and Cofer, GP and Johnson,
             GA},
   Title = {Use of nuclear magnetic resonance microscopy for noninvasive
             observations of root-soil water relations},
   Journal = {Theoretical and Applied Climatology},
   Volume = {42},
   Number = {4},
   Pages = {229-236},
   Year = {1990},
   ISSN = {0177-798X},
   url = {http://dx.doi.org/10.1007/BF00865983},
   Abstract = {As part of our strategy to study root-soil water
             relationships, it was necessary to develop a nondestructive
             technique to detect small changes in water distribution in
             and near the root. Nuclear magnetic resonance imaging (MRI),
             clinically used to nondestructively and noninvasively
             acquire anatomical information, can also be used to observe
             water distribution in roots, soils and other plant tissues.
             In MRI, a sample is placed in a strong magnetic field and a
             sequence of radio frequency (rf) pulses and magnetic field
             gradients is used to measure the concentration and
             relaxation properties of protons, chiefly those associated
             with water. This information is then reconstructed into a
             digital image representing the spatial distribution of water
             in plant tissues and soil. Today, intact roots less than 1
             mm in diameter growing in soil or synthetic media can be
             clearly imaged in less than 4 minutes at resolutions
             typically less than 30μm. This permits rapid production of
             images that simultaneously distinguish temporal changes in
             water distribution in root tissue, the rhizosphere and the
             adjacent soil at microscopic levels. Applications of this
             technique for investigating plant-soil water relationships
             will be discussed. © 1990 Springer-Verlag.},
   Doi = {10.1007/BF00865983},
   Key = {Brown90}
}

@booklet{Stern90,
   Author = {Stern, RL and Johnson, GA and Ravin, CE},
   Title = {Magnetic resonance imaging of the thoracic cavity using a
             paused 3DFT acquisition technique.},
   Journal = {Magnetic Resonance Imaging},
   Volume = {8},
   Number = {6},
   Pages = {747-753},
   Year = {1990},
   ISSN = {0730-725X},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/2266801},
   Abstract = {A new pulse sequence designed for magnetic resonance imaging
             of the entire thoracic cavity is described. This sequence,
             called 3DPAUSE, is a rapid three-dimensional Fourier
             transform (3DFT) sequences with periodic pauses for
             breathing and additional rf pulses after each pause to
             restore the magnetization to steady-state before data
             acquisition resumes. Cardiac motion artifacts are
             effectively removed by signal averaging. Respiratory motion
             artifacts are removed by breath hold. Image artifacts caused
             by an inadequate number of pauses or by inappropriate
             placement of the pauses within a scan are shown, and ways to
             avoid these artifacts are discussed. 3DPAUSE provides the
             ability to acquire three-dimensional arrays in the thoracic
             cavity with minimal artifacts from respiratory and cardiac
             motions in a clinically reasonable time.},
   Key = {Stern90}
}

@booklet{Cassel90,
   Author = {Cassel, DK and Brown, JM and Johnson, GA},
   Title = {Computer tomographic analysis of water distribution and flow
             in porous media},
   Journal = {Theoretical and Applied Climatology},
   Volume = {42},
   Number = {4},
   Pages = {223-228},
   Year = {1990},
   ISSN = {0177-798X},
   url = {http://dx.doi.org/10.1007/BF00865982},
   Abstract = {Computer tomography (CT) is the reconstruction by computer
             of a tomographic plane (slice) of an object. The tomograph
             is developed from multiple X-ray absorption measurements
             (scans) made around the periphery of the object. Recent
             research in soil science indicates that CT, which has been
             used in the medical field for 17 years, may find
             applications in assessing the degree of uniformity, or lack
             thereof, of soils and other porous media, in determining the
             flow paths of water and solutes through soils and porous
             materials, and in determing the flow paths of water and
             solutes to roots of plants. This paper discusses the general
             concept of CT, some of the capabilities associated with
             software used to format the CT readings into the desired
             images, and presents some CT scan data for several draining
             porous media. © 1990 Springer-Verlag.},
   Doi = {10.1007/BF00865982},
   Key = {Cassel90}
}

@booklet{Macfall90,
   Author = {MacFall, JS and Johnson, GA and Kramer, PJ},
   Title = {Observation of a water-depletion region surrounding loblolly
             pine roots by magnetic resonance imaging.},
   Journal = {Proceedings of the National Academy of Sciences of
             USA},
   Volume = {87},
   Number = {3},
   Pages = {1203-1207},
   Year = {1990},
   Month = {February},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/11607063},
   Abstract = {Magnetic resonance imaging was used to study sand containing
             various amounts of water and roots of loblolly pine planted
             into similar sand. Spin-lattice (T1) relaxation times of
             sand with water contents ranging from 0 to 25% (wt/wt)
             ranged from 472 to 1265 ms and increased with water content.
             Spin-spin (T2) relaxation times ranged from 54 to 76 ms and
             did not change in a discernible pattern with water content.
             Based on water content and measured T1 and T2 values, the
             signal intensity of sand/water images was predicted to
             increase with water content in a linear fashion, with the
             slope of the lines increasing with the time of acquisition
             repetition (TR). Measured signal intensity from images of
             sand with various water contents was found to follow a
             similar pattern. This allows interpretation of dark images
             of sand/water to be regions of low water content, and bright
             images to have comparatively greater water content. Images
             of loblolly pine seedling roots planted in identical sand
             showed the formation of a distinct water-depletion region
             first around the woody taproot and later showed the region
             extended and expanded around the lateral roots and clusters
             of mycorrhizal short roots. This observation strongly
             suggests that water uptake is occurring through the
             suberized region of the woody taproot.},
   Key = {Macfall90}
}

@article{fds132791,
   Author = {JS MacFall and GA Johnson and PJ Kramer},
   Title = {Observation of a water-depletion region surrounding loblolly
             pine roots by magnetic resonance imaging.},
   Journal = {Proceedings of the National Academy of Sciences of the
             United States of America, United States},
   Volume = {87},
   Number = {3},
   Pages = {1203-7},
   Year = {1990},
   Month = {February},
   ISSN = {1091-6490},
   Abstract = {Magnetic resonance imaging was used to study sand containing
             various amounts of water and roots of loblolly pine planted
             into similar sand. Spin-lattice (T1) relaxation times of
             sand with water contents ranging from 0 to 25% (wt/wt)
             ranged from 472 to 1265 ms and increased with water content.
             Spin-spin (T2) relaxation times ranged from 54 to 76 ms and
             did not change in a discernible pattern with water content.
             Based on water content and measured T1 and T2 values, the
             signal intensity of sand/water images was predicted to
             increase with water content in a linear fashion, with the
             slope of the lines increasing with the time of acquisition
             repetition (TR). Measured signal intensity from images of
             sand with various water contents was found to follow a
             similar pattern. This allows interpretation of dark images
             of sand/water to be regions of low water content, and bright
             images to have comparatively greater water content. Images
             of loblolly pine seedling roots planted in identical sand
             showed the formation of a distinct water-depletion region
             first around the woody taproot and later showed the region
             extended and expanded around the lateral roots and clusters
             of mycorrhizal short roots. This observation strongly
             suggests that water uptake is occurring through the
             suberized region of the woody taproot.},
   Key = {fds132791}
}

@booklet{Ruwart90,
   Author = {M. J. Ruwart and S. K. Sharma and D. W. Harris and D. B.
             Lakings and B. D. Rush and K. F. Wilkinson and J. C.
             Cornette and D. B. Evans and J. M. Friis and K. J. Cook and G. A. Johnson},
   Title = {Development of a sensitive activity assay for high-volume
             evaluation of human renin inhibitory peptides in rat serum -
             results with u-71,038},
   Journal = {Pharmaceutical Research},
   Volume = {7},
   Number = {4},
   Pages = {407 -- 410},
   Year = {1990},
   Month = {April},
   Key = {Ruwart90}
}

@booklet{Murad90,
   Author = {S. Murad and L. C. Walker and G. A. Johnson and S. R.
             Pinnell},
   Title = {A comparison of the inhibitory potential of minoxidil and
             its structural analogs toward lysyl hydroxylase in cultured
             fibroblasts},
   Journal = {Clinical Research},
   Volume = {38},
   Number = {2},
   Pages = {A667 -- A667},
   Year = {1990},
   Month = {April},
   Key = {Murad90}
}

@booklet{Murad90a,
   Author = {S. Murad and L. C. Walker and G. A. Johnson and S. R.
             Pinnell},
   Title = {A comparison of the inhibitory potential of minoxidil and
             its structural analogs toward lysyl hydroxylase in cultured
             fibroblasts},
   Journal = {Journal Of Investigative Dermatology},
   Volume = {94},
   Number = {4},
   Pages = {557 -- 557},
   Year = {1990},
   Month = {April},
   Key = {Murad90a}
}

@article{fds174159,
   Author = {P Riddle and GA Johnson},
   Title = {Sexual harassment: what role should health educators
             play?},
   Journal = {Health education},
   Volume = {14},
   Number = {1},
   Pages = {20-3},
   Year = {1990},
   Month = {April},
   ISSN = {0097-0050},
   Keywords = {Adaptation, Psychological • Employee Grievances •
             Female • Health Education* • Humans • Male
             • Sexual Behavior* • Social Behavior*},
   Language = {eng},
   Key = {fds174159}
}

@booklet{Johnson90,
   Author = {G. A. Johnson and C. Wilken and E. A. Vankirk and E. L.
             Belden and W. J. Murdoch},
   Title = {Toward regulation of gonadal-function by a synthetic hybrid
             molecule composed of gonadotropin and fc fragment of
             immunoglobulin-g},
   Journal = {American Journal Of Reproductive Immunology},
   Volume = {23},
   Number = {1},
   Pages = {22 -- 25},
   Year = {1990},
   Month = {May},
   Key = {Johnson90}
}

@booklet{Farmer90,
   Author = {Farmer, TH and Cofer, GP and Johnson, GA},
   Title = {Maximizing contrast to noise with inductively coupled
             implanted coils.},
   Journal = {Investigative Radiology},
   Volume = {25},
   Number = {5},
   Pages = {552-558},
   Year = {1990},
   Month = {May},
   ISSN = {0020-9996},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/2345087},
   Abstract = {Magnetic resonance (MR) microscopy with inductively coupled
             implanted coils has been used previously to follow loss and
             return of intra-medullary contrast as a result of
             nephrotoxic acute tubular necrosis with 117 microns
             resolution over a 2000 microns thick slice. The purpose of
             the current study was to further investigate the
             capabilities of in vivo MR microscopy by combining the
             implanted coil imaging technique with spin echo pulse
             sequence optimization done through signal-to-noise ratio
             (SNR) and contrast-to-noise ratio (CNR) modeling. These
             models included consideration of the effects of T2* and
             sampling time on signal-to-noise and contrast-to-noise
             ratios. They were initially tested with GdCl3 and agar gel
             phantoms constructed to the relaxation time and spin density
             specifications of the intra-medullary junction which bridges
             the outer and inner stripe of the outer medulla. In vivo
             microscopy was performed using single turn radiofrequency
             (RF) coils that were surgically implanted around the left
             kidney of two rats and inductively coupled to an external
             "birdcage" body coil. The models revealed maximum CNR per
             unit imaging time at a TR of 800 msec. A TE of 16 msec
             proved to be the best compromise between loss of transverse
             magnetization and decreased bandwidth. These CNR predictions
             were supported by the gel phantom and in vivo data.
             Maximizing the CNR in the current study enabled us to
             improve the resolution of in vivo MR microscopy to 78
             microns over a 1000 microns slice with an SNR of 40 and a
             CNR of eight in a total imaging time of 54
             minutes.},
   Key = {Farmer90}
}

@article{fds132831,
   Author = {TH Farmer and GP Cofer and GA Johnson},
   Title = {Maximizing contrast to noise with inductively coupled
             implanted coils.},
   Journal = {Investigative radiology, UNITED STATES},
   Volume = {25},
   Number = {5},
   Pages = {552-8},
   Year = {1990},
   Month = {May},
   ISSN = {0020-9996},
   Keywords = {Animals • Kidney • Magnetic Resonance Imaging
             • Microscopy • Models, Structural • Rats
             • Rats, Inbred Strains • anatomy & histology
             • instrumentation • instrumentation* •
             methods},
   Abstract = {Magnetic resonance (MR) microscopy with inductively coupled
             implanted coils has been used previously to follow loss and
             return of intra-medullary contrast as a result of
             nephrotoxic acute tubular necrosis with 117 microns
             resolution over a 2000 microns thick slice. The purpose of
             the current study was to further investigate the
             capabilities of in vivo MR microscopy by combining the
             implanted coil imaging technique with spin echo pulse
             sequence optimization done through signal-to-noise ratio
             (SNR) and contrast-to-noise ratio (CNR) modeling. These
             models included consideration of the effects of T2* and
             sampling time on signal-to-noise and contrast-to-noise
             ratios. They were initially tested with GdCl3 and agar gel
             phantoms constructed to the relaxation time and spin density
             specifications of the intra-medullary junction which bridges
             the outer and inner stripe of the outer medulla. In vivo
             microscopy was performed using single turn radiofrequency
             (RF) coils that were surgically implanted around the left
             kidney of two rats and inductively coupled to an external
             "birdcage" body coil. The models revealed maximum CNR per
             unit imaging time at a TR of 800 msec. A TE of 16 msec
             proved to be the best compromise between loss of transverse
             magnetization and decreased bandwidth. These CNR predictions
             were supported by the gel phantom and in vivo data.
             Maximizing the CNR in the current study enabled us to
             improve the resolution of in vivo MR microscopy to 78
             microns over a 1000 microns slice with an SNR of 40 and a
             CNR of eight in a total imaging time of 54
             minutes.},
   Key = {fds132831}
}

@article{fds174217,
   Author = {GA Johnson and C Wilken and EA Van Kirk and EL Belden and WJ
             Murdoch},
   Title = {Toward regulation of gonadal function by a synthetic hybrid
             molecule composed of gonadotropin and Fc fragment of
             immunoglobulin G.},
   Journal = {American journal of reproductive immunology (New York, N.Y.
             : 1989)},
   Volume = {23},
   Number = {1},
   Pages = {22-5},
   Year = {1990},
   Month = {May},
   ISSN = {1046-7408},
   Keywords = {Animals • Cell Survival • Chorionic Gonadotropin
             • Cross-Linking Reagents • Immunoglobulin Fc
             Fragments • Immunoglobulin G • Leydig Cells •
             Luteinizing Hormone • Male • Reproduction •
             Sheep • Testis • Testosterone • Tumor Cells,
             Cultured • blood • drug effects • drug
             effects* • immunology • metabolism •
             pharmacology*},
   Abstract = {A conjugate of human chorionic gonadotropin (HCG) and Fc
             fragment of immunoglobulin G was prepared by covalent
             cross-linking using the heterobifunctional reagent,
             N-succinimidyl 3-(2-pyridyldithio) propionate. Mouse Leydig
             tumor cells expressing receptors for luteinizing hormone
             were specifically lysed in vitro as a consequence of
             complement fixation via the Fc component of the hybrid
             molecule. Furthermore, administration of HCG-Fc to rams
             caused an acute depression in circulatory testosterone. This
             novel concept of targeted inhibition of gonadal function
             could prove to have future applications in control of
             reproductive processes.},
   Language = {eng},
   Key = {fds174217}
}

@booklet{Johnson90a,
   Author = {G. A. Johnson and J. Baker},
   Title = {Colonic perforation following mild trauma in a patient with
             crohns-disease},
   Journal = {American Journal Of Emergency Medicine},
   Volume = {8},
   Number = {4},
   Pages = {340 -- 341},
   Year = {1990},
   Month = {July},
   Key = {Johnson90a}
}

@article{fds132916,
   Author = {GA Johnson and J Baker},
   Title = {Colonic perforation following mild trauma in a patient with
             Crohn's disease.},
   Journal = {The American journal of emergency medicine, UNITED
             STATES},
   Volume = {8},
   Number = {4},
   Pages = {340-1},
   Year = {1990},
   Month = {July},
   ISSN = {0735-6757},
   Keywords = {Adult • Colon • Crohn Disease • Humans •
             Intestinal Perforation • Male • complications*
             • etiology* • injuries* • pathology •
             surgery},
   Abstract = {A 26-year-old man with a history of Crohn's disease was
             struck in the abdomen by an opponent's shoulder while
             playing basketball. He presented to the emergency department
             3 hours later with the complaint of abdominal pain and was
             admitted to the hospital for observation. Nine hours after
             presentation a computed tomography scan showed he had
             pneumoperitoneum and then underwent laparotomy. A perforated
             segment of sigmoid colon with severe inflammatory disease
             was found and resected. The rest of his small and large
             bowels were otherwise unremarkable. His localized but severe
             inflammatory bowel disease predisposed him to bowel
             perforation with minimal trauma. This is the first report of
             a patient with inflammatory bowel disease and traumatic
             colon perforation; it is also the first report of a patient
             with a bowel perforation with minimal traumatic
             force.},
   Key = {fds132916}
}

@booklet{Buhl90,
   Author = {A. E. Buhl and D. J. Waldon and C. A. Baker and G. A.
             Johnson},
   Title = {Minoxidil sulfate is the active metabolite that stimulates
             hair-follicles},
   Journal = {Journal Of Investigative Dermatology},
   Volume = {95},
   Number = {5},
   Pages = {553 -- 557},
   Year = {1990},
   Month = {November},
   Key = {Buhl90}
}

@booklet{Upfal90,
   Author = {M. J. Upfal and G. A. Johnson and A. P. Jacobson and P. A.
             Brady and J. A. Campbell},
   Title = {Indoor radon and lung-cancer in china},
   Journal = {Journal Of The National Cancer Institute},
   Volume = {82},
   Number = {21},
   Pages = {1722 -- 1722},
   Year = {1990},
   Month = {November},
   Key = {Upfal90}
}

@article{fds132904,
   Author = {MJ Upfal and GA Johnson and AP Jacobson and PA Brady and JA
             Campbell},
   Title = {Indoor radon and lung cancer in China.},
   Journal = {Journal of the National Cancer Institute, UNITED
             STATES},
   Volume = {82},
   Number = {21},
   Pages = {1722-3},
   Year = {1990},
   Month = {November},
   ISSN = {0027-8874},
   Keywords = {Air Pollutants • Carcinogens • China • Dust
             • Female • Humans • Lung Neoplasms •
             Radon • adverse effects • epidemiology •
             etiology* • toxicity • toxicity*},
   Key = {fds132904}
}

@article{fds174250,
   Author = {AE Buhl and DJ Waldon and CA Baker and GA Johnson},
   Title = {Minoxidil sulfate is the active metabolite that stimulates
             hair follicles.},
   Journal = {The Journal of investigative dermatology},
   Volume = {95},
   Number = {5},
   Pages = {553-7},
   Year = {1990},
   Month = {November},
   ISSN = {0022-202X},
   Keywords = {Acetaminophen • Animals • Cells, Cultured •
             Chlorates • Diethylcarbamazine • Hair • Mice
             • Minoxidil • Sulfotransferases • Vibrissae
             • analogs & derivatives* • antagonists &
             inhibitors • cytology • drug effects • drug
             effects* • enzymology • metabolism •
             pharmacology},
   Abstract = {An important step in understanding minoxidil's mechanism of
             action on hair follicles was to determine the drug's active
             form. We used organ-cultured vibrissa follicles to test
             whether it is minoxidil or its sulfated metabolite,
             minoxidil sulfate, that stimulates hair growth. Follicles
             from neonatal mice were cultured with or without drugs and
             effects were assessed by measuring incorporation of
             radiolabeled cysteine in hair shafts of the treated
             follicles. Assays of minoxidil sulfotransferase activity
             indicated that vibrissae follicles metabolize minoxidil to
             minoxidil sulfate. Dose-response studies showed that
             minoxidil sulfate is 14 times more potent than minoxidil in
             stimulating cysteine incorporation in cultured follicles.
             Three drugs that block production of intrafollicular
             minoxidil sulfate were tested for their effects on
             drug-induced hair growth. Diethylcarbamazine proved to be a
             noncompetitive inhibitor of sulfotransferase and prevented
             hair growth stimulation by minoxidil but not by minoxidil
             sulfate. Inhibiting the formation of intracellular PAPS with
             chlorate also blocked the action of minoxidil but not of
             minoxidil sulfate. Acetaminophen, a potent sulfate scavenger
             blocked cysteine incorporation by minoxidil. It also blocked
             follicular stimulation by minoxidil sulfate apparently by
             directly removing the sulfate from the drug. Experiments
             with U-51,607, a potent minoxidil analog that also forms a
             sulfated metabolite, showed that its activity was inhibited
             by both chlorate and diethylcarbamazine. These studies show
             that sulfation is a critical step for hair-growth effects of
             minoxidil and that it is the sulfated metabolite that
             directly affects hair follicles.},
   Language = {eng},
   Key = {fds174250}
}

@booklet{Zelei90,
   Author = {B. V. Zelei and C. J. Walker and G. A. Sawada and T. T.
             Kawabe and K. A. Knight and A. E. Buhl and G. A. Johnson and A. R. Diani},
   Title = {Immunohistochemical and autoradiographic findings suggest
             that minoxidil is not localized in specific cells of
             vibrissa, pelage, or scalp follicles},
   Journal = {Cell And Tissue Research},
   Volume = {262},
   Number = {3},
   Pages = {407 -- 413},
   Year = {1990},
   Month = {December},
   Key = {Zelei90}
}

@article{fds174107,
   Author = {BV Zelei and CJ Walker and GA Sawada and TT Kawabe and KA Knight and AE
             Buhl, GA Johnson and AR Diani},
   Title = {Immunohistochemical and autoradiographic findings suggest
             that minoxidil is not localized in specific cells of
             vibrissa, pelage, or scalp follicles.},
   Journal = {Cell and tissue research},
   Volume = {262},
   Number = {3},
   Pages = {407-13},
   Year = {1990},
   Month = {December},
   ISSN = {0302-766X},
   Keywords = {Animals • Autoradiography • Hair •
             Immunohistochemistry • Male • Melanins •
             Minoxidil • Rats • Scalp • Vibrissae •
             cytology* • metabolism • metabolism*},
   Abstract = {Immunohistochemistry with a minoxidil antibody suggested
             that minoxidil-immunoreactivity is associated with the root
             sheaths, laterally orientated differentiating matrix cells,
             and dividing epithelial cells of cultured vibrissa follicles
             of pigmented and albino neonatal mice. The dermal papilla
             and connective tissue sheath were devoid of
             minoxidil-immunoreactivity. To verify that
             minoxodil-immunoreactivity in the follicles was specific,
             immunostaining was conducted with dissected whisker pads,
             formalin-fixed "dead" follicles, and sections of spleen,
             liver and kidney (non-haired organs) cultured with
             minoxidil. Microscopic examination revealed
             minoxidil-immunoreactivity in all of these tissues.
             Follicles and whisker pads cultured with minoxidil, then
             washed for one h in media were devoid of
             minoxidil-immunoreactivity. These data suggest that
             minoxidil-immunoreactivity in cultured vibrissa follicles is
             probably non-specific. Sections of skin from C3H and CF1
             mice which were topically dosed with minoxidil (in vivo)
             showed no minoxidil-immunoreactivity. Autoradiography
             demonstrated that tritiated minoxidil was bound in vivo and
             in vitro only to melanin granules in pigmented follicles of
             rodent and human tissue. This is probably non-specific
             binding since melanin is known to accumulate several
             chemically and pharmacologically unrelated drugs. It is
             reasonable to conclude that, under the conditions of these
             experiments, minoxidil is not specifically localized in any
             cells of whisker, pelage or, scalp follicles.},
   Language = {eng},
   Key = {fds174107}
}

@article{fds268776,
   Author = {Shattuck, M and Behringer, R and Geordiadis, J and Johnson,
             GA},
   Title = {Magnetic resonance imaging of interstitial velocity
             distributions in porous media},
   Journal = {American Society of Mechanical Engineers, Fluids Engineering
             Division (Publication) FED},
   Volume = {125},
   Pages = {39-45},
   Year = {1991},
   Abstract = {In this article we report on a promising application of
             Magnetic Resonance Imaging (MRI), which can measure local
             interstitial velocity distributions inside fully-saturated
             porous media. We have extended the standard
             three-dimensional MRI sequence to include local velocity
             information. During flow, the moving spins of the fluid (in
             this case water) accumulate phase in the presence of
             magnetic field gradients. This phase is proportional to the
             local velocity. By repeating the measurement under the
             influence of different magnetic gradient strengths, we can
             reconstruct the velocity distribution in each volume element
             (voxel). Using this technique to study pressure-driven flow
             through a fully-saturated, cylindrical packed bed, we have
             observed flow channeling near the walls and an exponential
             distribution of velocities.},
   Key = {fds268776}
}

@booklet{Baxter91,
   Author = {BAXTER, GW and LEONE, R and JOHNSON, GA and BEHRINGER,
             RP},
   Title = {TIME-DEPENDENCE, SCALING AND PATTERN-FORMATION FOR FLOWING
             SAND},
   Journal = {European Journal of Mechanics - B/Fluids},
   Volume = {10},
   Number = {2},
   Pages = {181-186},
   Year = {1991},
   ISSN = {0997-7546},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1991FR81800029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Baxter91}
}

@booklet{Hedlund91,
   Author = {Hedlund, LW and Maronpot, RR and Johnson, GA and Cofer, GP and Mills,
             GI and Wheeler, CT},
   Title = {Magnetic resonance microscopy of toxic renal injury induced
             by bromoethylamine in rats},
   Journal = {Fundamental and Applied Toxicology},
   Volume = {16},
   Number = {4},
   Pages = {787-797},
   Year = {1991},
   ISSN = {0272-0590},
   Abstract = {The alkylhalide 2-bromoethylamine hydrobromide (BEA)
             produces renal injury in rats that mimics analgesic-related
             renal injury in humans. Our purpose was to examine this
             injury, in vivo in rats, with magnetic resonance (MR)
             microscopy and correlate MR findings with findings from
             light microscopy of hematoxylin-eosin-stained sections. Rats
             (n = 48) were injected intravenously with BEA (150 mg/kg) or
             saline and imaged with MR 6, 48, and 336 hr later. The
             spin-spin relaxation time, T2, was measured from the cortex
             to the papilla. In other rats, we measured regional water
             content of the kidney. Renal injury was present 48 and 336
             hr after BEA dosing based on increased renal organ weights,
             decreased urine specific gravity, and significant renal
             lesions (H & E). T2 was elevated in the inner stripe of
             the outer medulla in injured kidneys at 48 hr. The
             differences in T2 between cortex and outer medulla were also
             elevated 48 hr after BEA. In the inner medulla, there were
             no changes in T2 after BEA treatment. However, in all groups
             there were significant regional differences in T2. The value
             of T2 increased from outer to inner medulla and this
             gradient was directly correlated with water content. Thus,
             MR microscopy detected damage in the outer medulla after BEA
             injury but not the damage in the inner medulla. T2 appeared
             to reflect the water content in the different regions of the
             medulla. The noninvasive in vivo capability of MR
             microscopy, with its high sensitivity to tissue water,
             allows the toxicologist to monitor the progression and
             regression of toxic insult in the same animal. At present
             the technology is complicated. The precise and accurate
             measure of MR-sensitive parameters in live animals at
             microscopic resolution is difficult. However, as the
             technology matures, there will be significant improvements
             providing the toxicologist a unique in vivo tool. ©
             1991.},
   Key = {Hedlund91}
}

@booklet{Maki91a,
   Author = {Maki, JH and Benveniste, H and MacFall, JR and Johnson,
             GA},
   Title = {Maximization of contrast-to-noise ratio to distinguish
             diffusion and microcirculatory flow.},
   Journal = {Journal of Magnetic Resonance Imaging},
   Volume = {1},
   Number = {1},
   Pages = {39-46},
   Year = {1991},
   Month = {January},
   ISSN = {1053-1807},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/1802129},
   Abstract = {Optimization of the contrast-to-noise ratio (CNR) is
             described for microcirculation magnetic resonance (MR)
             imaging techniques based on flow-compensated/flow-dephased
             sequences, both with and without even-echo rephasing. The
             authors present the most advantageous manner of applying
             flow-dephased gradients, such that dephasing is maximal
             while diffusion losses are minimal. The theoretical
             considerations include phase, diffusion, echo time, and
             bandwidth in the determination of the optimal parameters for
             microcirculation imaging. Studies in phantoms consisting of
             stationary and flowing copper sulfate in Sephadex columns
             demonstrate the validity of the calculations. Optimized in
             vivo images of a rat stroke model demonstrate the potential
             of the flow-compensated/flow-dephased technique and the
             importance of optimizing CNR.},
   Key = {Maki91a}
}

@booklet{Maki91b,
   Author = {Maki, JH and MacFall, JR and Johnson, GA},
   Title = {The use of gradient flow compensation to separate diffusion
             and microcirculatory flow in MRI.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {17},
   Number = {1},
   Pages = {95-107},
   Year = {1991},
   Month = {January},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/1712421},
   Abstract = {This paper describes a new MR imaging technique termed
             Modified Stejskal Tanner versus Flow Compensation (MST/FC)
             for the separation of diffusion and microcirculatory flow.
             The theory behind the sequence is explained, along with a
             five-component model of microcirculation applicable to any
             "perfusion" imaging technique. Phantom data is presented
             showing that (1) diffusion effects can be matched between
             MST and FC (suggesting the possibility of flow-compensated
             diffusion imaging), and (2) the technique is a quantitative
             method of separating diffusion and slow (less than 0.25
             mm/s) tortuous flow through a Sephadex column. Furthermore,
             animal images show the technique to be feasible and
             quantitative in measuring rat brain microcirculation under
             normal, vasodilated (hypercarbia), and no-flow (post mortem)
             conditions.},
   Key = {Maki91b}
}

@booklet{Veres91a,
   Author = {VERES, JS and JOHNSON, GA and KRAMER, PJ},
   Title = {INVIVO MAGNETIC-RESONANCE-IMAGING OF BLECHNUM FERNS -
             CHANGES IN T1 AND N(H) DURING DEHYDRATION AND
             REHYDRATION},
   Journal = {American journal of botany},
   Volume = {78},
   Number = {1},
   Pages = {80-88},
   Year = {1991},
   Month = {January},
   ISSN = {0002-9122},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1991EW16700009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.2307/2445231},
   Key = {Veres91a}
}

@article{fds132760,
   Author = {JH Maki, JR MacFall and GA Johnson},
   Title = {The use of gradient flow compensation to separate diffusion
             and microcirculatory flow in MRI.},
   Journal = {Magnetic resonance in medicine : official journal of the
             Society of Magnetic Resonance in Medicine / Society of
             Magnetic Resonance in Medicine, UNITED STATES},
   Volume = {17},
   Number = {1},
   Pages = {95-107},
   Year = {1991},
   Month = {January},
   ISSN = {0740-3194},
   Keywords = {Acetone • Animals • Brain • Dextrans •
             Diffusion • Edetic Acid • Female • Gadolinium
             • Gels • Image Enhancement • Magnetic
             Resonance Imaging • Microcirculation • Models,
             Biological • Models, Structural • Rats •
             Rats, Inbred F344 • Reproducibility of Results •
             Rheology • Water • blood supply • chemistry
             • instrumentation • methods* •
             physiology*},
   Abstract = {This paper describes a new MR imaging technique termed
             Modified Stejskal Tanner versus Flow Compensation (MST/FC)
             for the separation of diffusion and microcirculatory flow.
             The theory behind the sequence is explained, along with a
             five-component model of microcirculation applicable to any
             "perfusion" imaging technique. Phantom data is presented
             showing that (1) diffusion effects can be matched between
             MST and FC (suggesting the possibility of flow-compensated
             diffusion imaging), and (2) the technique is a quantitative
             method of separating diffusion and slow (less than 0.25
             mm/s) tortuous flow through a Sephadex column. Furthermore,
             animal images show the technique to be feasible and
             quantitative in measuring rat brain microcirculation under
             normal, vasodilated (hypercarbia), and no-flow (post mortem)
             conditions.},
   Key = {fds132760}
}

@booklet{Benveniste91,
   Author = {Benveniste, H and Cofer, GP and Piantadosi, CA and Davis, JN and Johnson, GA},
   Title = {Quantitative proton magnetic resonance imaging in focal
             cerebral ischemia in rat brain.},
   Journal = {Stroke},
   Volume = {22},
   Number = {2},
   Pages = {259-268},
   Year = {1991},
   Month = {February},
   ISSN = {0039-2499},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/2003291},
   Abstract = {Proton magnetic resonance (MR) imaging has been recommended
             as a diagnostic tool for the detection of focal cerebral
             ischemia. We compared microscopic MR images of rat brains
             after focal cerebral ischemia with evidence of histological
             damage found on corresponding silver-impregnated or cresyl
             violet-stained brain sections. Ten male Wistar rats were
             subjected to permanent unilateral occlusions of the right
             middle cerebral and common carotid arteries under halothane
             anesthesia. Twenty-four hours later the area of injury on MR
             images amounted to 26% of the total slice area, whereas only
             9% of the total slice area was necrotic on histological
             sections from the same animals. The infarcted areas on
             tissue sections were surrounded by regions of selective
             neuronal injury in the cerebral cortex and occasionally in
             the hippocampus. The area of injury on MR images was larger
             than the combined areas of infarction and selective neuronal
             injury on histological sections. Areas of increased T2
             values on MR images extended medially into noninfarcted
             striatum and laterally and dorsally into noninfarcted
             cortex. The lateral and dorsal areas on MR images frequently
             coincided with cortical areas in which considerable
             selective neuronal injury was present in the upper cortical
             layers. We hypothesize that the abnormal areas on MR images
             above histologically normal brain tissue represent the
             ischemic penumbra. If true, this is the first demonstration
             of the ischemic penumbra by MR imaging and may reflect our
             use of Wistar rats, a new image analysis technique, and
             ultra-high resolution MR imaging.},
   Key = {Benveniste91}
}

@article{fds132838,
   Author = {H Benveniste and GP Cofer and CA Piantadosi and JN Davis and GA
             Johnson},
   Title = {Quantitative proton magnetic resonance imaging in focal
             cerebral ischemia in rat brain.},
   Journal = {Stroke; a journal of cerebral circulation, UNITED
             STATES},
   Volume = {22},
   Number = {2},
   Pages = {259-68},
   Year = {1991},
   Month = {February},
   ISSN = {0039-2499},
   Keywords = {Animals • Brain • Brain Ischemia • Cerebral
             Infarction • Diagnosis, Computer-Assisted •
             Magnetic Resonance Imaging* • Necrosis • Rats
             • Rats, Inbred Strains • Silver • diagnosis
             • diagnosis* • diagnostic use • pathology
             • pathology*},
   Abstract = {Proton magnetic resonance (MR) imaging has been recommended
             as a diagnostic tool for the detection of focal cerebral
             ischemia. We compared microscopic MR images of rat brains
             after focal cerebral ischemia with evidence of histological
             damage found on corresponding silver-impregnated or cresyl
             violet-stained brain sections. Ten male Wistar rats were
             subjected to permanent unilateral occlusions of the right
             middle cerebral and common carotid arteries under halothane
             anesthesia. Twenty-four hours later the area of injury on MR
             images amounted to 26% of the total slice area, whereas only
             9% of the total slice area was necrotic on histological
             sections from the same animals. The infarcted areas on
             tissue sections were surrounded by regions of selective
             neuronal injury in the cerebral cortex and occasionally in
             the hippocampus. The area of injury on MR images was larger
             than the combined areas of infarction and selective neuronal
             injury on histological sections. Areas of increased T2
             values on MR images extended medially into noninfarcted
             striatum and laterally and dorsally into noninfarcted
             cortex. The lateral and dorsal areas on MR images frequently
             coincided with cortical areas in which considerable
             selective neuronal injury was present in the upper cortical
             layers. We hypothesize that the abnormal areas on MR images
             above histologically normal brain tissue represent the
             ischemic penumbra. If true, this is the first demonstration
             of the ischemic penumbra by MR imaging and may reflect our
             use of Wistar rats, a new image analysis technique, and
             ultra-high resolution MR imaging.},
   Key = {fds132838}
}

@booklet{Johnson91c,
   Author = {G. A. Johnson and C. A. Baker and K. A. Knight},
   Title = {Induction of minoxidil sulfotransferase (mst) activity
             during differentiation of normal human epidermal-keratinocytes
             (nheks)},
   Journal = {Faseb Journal},
   Volume = {5},
   Number = {6},
   Pages = {A1749 -- A1749},
   Year = {1991},
   Month = {March},
   Key = {Johnson91c}
}

@booklet{Suddarth91,
   Author = {SUDDARTH, SA and JOHNSON, GA},
   Title = {3-DIMENSIONAL MR MICROSCOPY WITH LARGE ARRAYS},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {18},
   Number = {1},
   Pages = {132-141},
   Year = {1991},
   Month = {March},
   ISSN = {0740-3194},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1991EZ54700013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1002/mrm.1910180114},
   Key = {Suddarth91}
}

@article{fds268894,
   Author = {Suddarth, SA and Johnson, GA},
   Title = {Three-dimensional MR microscopy with large
             arrays.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {18},
   Number = {1},
   Pages = {132-141},
   Year = {1991},
   Month = {March},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/2062225},
   Keywords = {Animals • Brain • Fourier Analysis • Kidney
             • Magnetic Resonance Imaging • Magnetic Resonance
             Spectroscopy • Rats • anatomy & histology •
             diagnostic use • instrumentation • methods •
             methods*},
   Abstract = {MR microscopy of fixed specimens is described using large
             (256(3] arrays. Images are acquired at 7.0 T with voxels as
             small as 70 x 70 x 70 microns (3.4 x 10(-4) mm3), more than
             25,000 times smaller than routine clinical body imaging.
             Separation of the acquisition, reconstruction, archival, and
             analysis onto networked workstations provides flexibility
             and efficiency in handling the large data sets. The
             isotropic data can be interactively displayed through any
             plane without loss of in-plane resolution. The potential for
             applications of MR microscopy in clinical pathology is
             addressed.},
   Key = {fds268894}
}

@booklet{Baker91,
   Author = {C. A. Baker and H. Uno and G. A. Johnson},
   Title = {Minoxidil sulfotransferase activity in hair-follicles},
   Journal = {Clinical Research},
   Volume = {39},
   Number = {2},
   Pages = {A537 -- A537},
   Year = {1991},
   Month = {April},
   Key = {Baker91}
}

@booklet{Baker91a,
   Author = {C. A. Baker and H. Uno and G. A. Johnson},
   Title = {Minoxidil sulfotransferase activity in hair-follicles},
   Journal = {Journal Of Investigative Dermatology},
   Volume = {96},
   Number = {4},
   Pages = {576 -- 576},
   Year = {1991},
   Month = {April},
   Key = {Baker91a}
}

@booklet{Malisch91,
   Author = {Malisch, TW and Hedlund, LW and Suddarth, SA and Johnson,
             GA},
   Title = {MR microscopy at 7.0 T: effects of brain
             iron.},
   Journal = {Journal of Magnetic Resonance Imaging},
   Volume = {1},
   Number = {3},
   Pages = {301-305},
   Year = {1991},
   Month = {May},
   ISSN = {1053-1807},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/1802143},
   Abstract = {The T2 of brain tissue is known to be field dependent,
             decreasing as B0 increases. Previous studies have attributed
             reduced T2 in the structures of the extrapyramidal motor
             system (EPMS) to high iron concentrations. The present study
             was designed to manipulate physiologic iron concentrations
             and study the effects on T2 and on the field dependence of
             T2 at 7.0 T in whole formalin-fixed brains. A rat model was
             devised in which iron concentrations in the structures of
             interest were altered by diet manipulation. Cerebral
             structures with different iron content were imaged and T2
             measured with MR microscopy at both 2.0 and 7.0 T. T2 of all
             tissues was shorter by 40%-60% at 7.0 T. Although some
             dependence of T2 on iron concentration was evident, it was
             less than expected. The strongest correlation was in the
             substantia nigra. The highest-resolution studies, at 30 x 30
             x 50 microns, show the myelin bundles in many of the EPMS
             structures but not in the substantia nigra. From these data,
             it appears that T2 at greater field strengths depends more
             on susceptibility-induced spin dephasing imposed by
             diffusion through the tissue microstructure than on the
             presence of iron.},
   Key = {Malisch91}
}

@article{fds269102,
   Author = {Hedlund, LW and Maronpot, RR and Johnson, GA and Cofer, GP and Mills,
             GI and Wheeler, CT},
   Title = {Magnetic resonance microscopy of toxic renal injury induced
             by bromoethylamine in rats.},
   Journal = {Fundamental and Applied Toxicology},
   Volume = {16},
   Number = {4},
   Pages = {787-797},
   Year = {1991},
   Month = {May},
   ISSN = {0272-0590},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/1884916},
   Keywords = {Animals • Ethylamines • Female • Kidney
             • Kidney Cortex • Kidney Diseases • Kidney
             Medulla • Magnetic Resonance Spectroscopy* •
             Microscopy • Organ Size • Rats • Rats, Inbred
             Strains • Specific Gravity • chemically induced*
             • methods* • pathology • pathology* •
             toxicity*},
   Abstract = {The alkylhalide 2-bromoethylamine hydrobromide (BEA)
             produces renal injury in rats that mimics analgesic-related
             renal injury in humans. Our purpose was to examine this
             injury, in vivo in rats, with magnetic resonance (MR)
             microscopy and correlate MR findings with findings from
             light microscopy of hematoxylin-eosin-stained sections. Rats
             (n = 48) were injected intravenously with BEA (150 mg/kg) or
             saline and imaged with MR 6, 48, and 336 hr later. The
             spin-spin relaxation time, T2, was measured from the cortex
             to the papilla. In other rats, we measured regional water
             content of the kidney. Renal injury was present 48 and 336
             hr after BEA dosing based on increased renal organ weights,
             decreased urine specific gravity, and significant renal
             lesions (H & E). T2 was elevated in the inner stripe of the
             outer medulla in injured kidneys at 48 hr. The differences
             in T2 between cortex and outer medulla were also elevated 48
             hr after BEA. In the inner medulla, there were no changes in
             T2 after BEA treatment. However, in all groups there were
             significant regional differences in T2. The value of T2
             increased from outer to inner medulla and this gradient was
             directly correlated with water content. Thus, MR microscopy
             detected damage in the outer medulla after BEA injury but
             not the damage in the inner medulla. T2 appeared to reflect
             the water content in the different regions of the medulla.
             The noninvasive in vivo capability of MR microscopy, with
             its high sensitivity to tissue water, allows the
             toxicologist to monitor the progression and regression of
             toxic insult in the same animal. At present the technology
             is complicated. The precise and accurate measure of
             MR-sensitive parameters in live animals at microscopic
             resolution is difficult. However, as the technology matures,
             there will be significant improvements providing the
             toxicologist a unique in vivo tool.},
   Key = {fds269102}
}

@booklet{Macfall91b,
   Author = {J. R. Macfall and J. H. Maki and G. A. Johnson and L.
             Hedlund and H. Benveniste and G. Copher},
   Title = {Diffusion microcirculation mri in the rat-brain},
   Journal = {Magnetic Resonance In Medicine},
   Volume = {19},
   Number = {2},
   Pages = {305 -- 310},
   Year = {1991},
   Month = {June},
   Key = {Macfall91b}
}

@booklet{Scoggins91,
   Author = {J. R. Scoggins and J. Arellano and B. Esposito and G. A.
             Johnson and K. C. Brundidge},
   Title = {Report on a symposium on air-sea interaction and air-mass
             modification over the gulf of mexico 7-9 january 1991,
             galveston, texas},
   Journal = {Bulletin Of The American Meteorological Society},
   Volume = {72},
   Number = {6},
   Pages = {827 -- 832},
   Year = {1991},
   Month = {June},
   Key = {Scoggins91}
}

@booklet{Johnson91a,
   Author = {Johnson, GA and Maki, JH},
   Title = {In vivo measurement of proton diffusion in the presence of
             coherent motion.},
   Journal = {Investigative Radiology},
   Volume = {26},
   Number = {6},
   Pages = {540-545},
   Year = {1991},
   Month = {June},
   ISSN = {0020-9996},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/1650333},
   Abstract = {Measurement of the self-diffusion coefficient D of water in
             tissue has been performed traditionally using the technique
             proposed by Stejskal and Tanner. A variant of that technique
             is shown here, employing flow-compensated gradients that
             significantly reduce the sensitivity to small coherent
             motions that are common in body imaging. An interleaved
             sequence with four values of diffusion-sensitizing gradient
             (b) minimizes registration errors. Eddy currents and other
             systematic errors are reduced, permitting the measurement of
             standards in an imaging context within 5% of nonimaging
             values in the literature. The flow-compensated sequence
             permits the measure of D for tissues in the abdominal cavity
             of the rat. We present in vivo measurements of D for the
             following rat tissues; liver, kidney (cortex), kidney
             (medulla) muscle, brain, fat.},
   Key = {Johnson91a}
}

@article{fds132790,
   Author = {GA Johnson and JH Maki},
   Title = {In vivo measurement of proton diffusion in the presence of
             coherent motion.},
   Journal = {Investigative radiology, UNITED STATES},
   Volume = {26},
   Number = {6},
   Pages = {540-5},
   Year = {1991},
   Month = {June},
   ISSN = {0020-9996},
   Keywords = {Acetone • Animals • Diffusion • Dimethyl
             Sulfoxide • Magnetic Resonance Imaging • Movement
             • Protons* • Rats • Water •
             methods*},
   Abstract = {Measurement of the self-diffusion coefficient D of water in
             tissue has been performed traditionally using the technique
             proposed by Stejskal and Tanner. A variant of that technique
             is shown here, employing flow-compensated gradients that
             significantly reduce the sensitivity to small coherent
             motions that are common in body imaging. An interleaved
             sequence with four values of diffusion-sensitizing gradient
             (b) minimizes registration errors. Eddy currents and other
             systematic errors are reduced, permitting the measurement of
             standards in an imaging context within 5% of nonimaging
             values in the literature. The flow-compensated sequence
             permits the measure of D for tissues in the abdominal cavity
             of the rat. We present in vivo measurements of D for the
             following rat tissues; liver, kidney (cortex), kidney
             (medulla) muscle, brain, fat.},
   Key = {fds132790}
}

@article{fds269122,
   Author = {MacFall, JR and Maki, JH and Johnson, GA and Hedlund, L and Benveniste,
             H and Copher, G},
   Title = {Diffusion/microcirculation MRI in the rat
             brain.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {19},
   Number = {2},
   Pages = {305-310},
   Year = {1991},
   Month = {June},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/1908936},
   Keywords = {Animals • Brain • Carbon Dioxide •
             Cerebrovascular Circulation • Diffusion • Magnetic
             Resonance Imaging* • Microcirculation • Rats
             • Rats, Inbred Strains • administration & dosage
             • anatomy & histology • blood supply •
             metabolism • pharmacokinetics •
             physiology*},
   Abstract = {The CO2 fraction of an anesthetized rat's breathing mixture
             was changed (from 0 to 10%) to attempt to change the brain
             microcirculation and observe these changes in diffusion
             measurements of the neural tissue. Brain apparent diffusion
             coefficients were measured to be (0.71 +/- 0.01) X 10(-3)
             mm2/s before sacrifice and (0.39 +/- 0.01) X 10(-3) mm2/s
             after sacrifice. Multiple diffusion components were
             observed, consistent with flowing material, but the extra
             components did not increase with increased CO2. It is
             proposed that the additional components may be due to
             extracellular, extravascular water such as
             CSF.},
   Key = {fds269122}
}

@booklet{Johnson91b,
   Author = {G. A. Johnson and V. J. Kapoor and M. Shokrani and L. J.
             Messick and R. Nguyen and R. A. Stall and M. A.
             Mckee},
   Title = {Indium gallium-arsenide microwave-power transistors},
   Journal = {Ieee Transactions On Microwave Theory And
             Techniques},
   Volume = {39},
   Number = {7},
   Pages = {1069 -- 1076},
   Year = {1991},
   Month = {July},
   Key = {Johnson91b}
}

@booklet{Macfall91a,
   Author = {MACFALL, JR and MAKI, JH and JOHNSON, GA and HEDLUND, LW and COFER,
             GP},
   Title = {PREMORTEM AND POSTMORTEM DIFFUSION-COEFFICIENTS IN RAT
             NEURAL AND MUSCLE TISSUES},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {20},
   Number = {1},
   Pages = {89-99},
   Year = {1991},
   Month = {July},
   ISSN = {0740-3194},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1991FU08200009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1002/mrm.1910200110},
   Key = {Macfall91a}
}

@article{fds268886,
   Author = {MacFall, JR and Maki, JH and Johnson, GA and Hedlund, LW and Cofer,
             GP},
   Title = {Pre- and postmortem diffusion coefficients in rat neural and
             muscle tissues.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {20},
   Number = {1},
   Pages = {89-99},
   Year = {1991},
   Month = {July},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/1943665},
   Keywords = {Animals • Body Temperature • Body Water •
             Brain • Cell Death • Death • Diffusion •
             Female • Image Enhancement • Magnetic Resonance
             Imaging • Male • Muscles • Rats • Rats,
             Inbred Strains • instrumentation • metabolism
             • metabolism* • methods* •
             pathology*},
   Abstract = {Pulsed gradient diffusion-weighted spin-echo images (7 to 11
             gradient strengths) were obtained in a coronal slice through
             the midbrain for five normal adult white rats before and
             after sacrifice in a 2-T CSI system with air temperature
             control. The pulse sequence was cardiac gated and
             respiratory synchronized in order to minimize motion
             artifacts (Tr greater than 2 s. Te = 30 ms). Diffusion
             coefficients reflecting several tissue compartments (D*) in
             brain and muscle were calculated and referenced to
             simultaneously imaged tubes of water. In the living animals,
             brain cortical matter had a value of D* = (0.82 +/- 0.02) x
             10(-3) mm2/s. deeper brain regions had a value of D* = (0.73
             +/- 0.02) x 10(-3) mm2/s, and the muscle had a value of D* =
             (1.4 +/- 0.1) x 10(-3) mm2/s. Postmortem the values in brain
             dropped by approximately 30%, while remaining constant in
             muscle. Signal intensity in the spin-echo images for muscle
             tissue rose by 50% over a 1- to 2-h interval after sacrifice
             while that of brain tissue remained relatively
             stable.},
   Key = {fds268886}
}

@booklet{Johnson91,
   Author = {G. A. Johnson},
   Title = {Research into psychiatric-disorder after stroke - the need
             for further-studies},
   Journal = {Australian And New Zealand Journal Of Psychiatry},
   Volume = {25},
   Number = {3},
   Pages = {358 -- 370},
   Year = {1991},
   Month = {September},
   Key = {Johnson91}
}

@booklet{Chotas91,
   Author = {Chotas, HG and Van Metter and RL and Johnson, GA and Ravin,
             CE},
   Title = {Small object contrast in AMBER and conventional chest
             radiography.},
   Journal = {Radiology},
   Volume = {180},
   Number = {3},
   Pages = {853-859},
   Year = {1991},
   Month = {September},
   ISSN = {0033-8419},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/1871306},
   Abstract = {The ability of a commercially available scanning
             equalization system for chest radiography to render small
             object contrast in the lung-, mediastinum-, and
             subdiaphragm-equivalent regions of an acrylic chest phantom
             was quantitatively evaluated. Images from nine chest
             phantoms that represented a wide range of patient sizes and
             dynamic ranges of x-ray transmittance were analyzed. Subject
             contrast was measured with a photostimulable phosphor
             detector, and images were acquired in both equalized and
             nonequalized (conventional) imaging modes. Available subject
             contrast in the lung-equivalent region was 8%-15% lower in
             the equalized images compared with the nonequalized images
             in all phantoms (patient types); contrast in the
             mediastinum-, retro-cardiac-, and subdiaphragm-equivalent
             regions was 11%-63% higher in the equalized images, with the
             degree of improvement increasing as patient size and dynamic
             range increased. Images of each phantom were also acquired
             with the screen-film systems currently in use at the
             authors' institution, permitting an assessment of the
             relative performance (in terms of radiographic contrast) of
             these imagers with and without use of equalization.},
   Doi = {10.1148/radiology.180.3.1871306},
   Key = {Chotas91}
}

@article{fds132870,
   Author = {HG Chotas and RL Van Metter and GA Johnson and CE
             Ravin},
   Title = {Small object contrast in AMBER and conventional chest
             radiography.},
   Journal = {Radiology, UNITED STATES},
   Volume = {180},
   Number = {3},
   Pages = {853-9},
   Year = {1991},
   Month = {September},
   ISSN = {0033-8419},
   Keywords = {Diaphragm • Humans • Lung • Mediastinum
             • Models, Structural • Radiography, Thoracic*
             • Technology, Radiologic • methods •
             radiography},
   Abstract = {The ability of a commercially available scanning
             equalization system for chest radiography to render small
             object contrast in the lung-, mediastinum-, and
             subdiaphragm-equivalent regions of an acrylic chest phantom
             was quantitatively evaluated. Images from nine chest
             phantoms that represented a wide range of patient sizes and
             dynamic ranges of x-ray transmittance were analyzed. Subject
             contrast was measured with a photostimulable phosphor
             detector, and images were acquired in both equalized and
             nonequalized (conventional) imaging modes. Available subject
             contrast in the lung-equivalent region was 8%-15% lower in
             the equalized images compared with the nonequalized images
             in all phantoms (patient types); contrast in the
             mediastinum-, retro-cardiac-, and subdiaphragm-equivalent
             regions was 11%-63% higher in the equalized images, with the
             degree of improvement increasing as patient size and dynamic
             range increased. Images of each phantom were also acquired
             with the screen-film systems currently in use at the
             authors' institution, permitting an assessment of the
             relative performance (in terms of radiographic contrast) of
             these imagers with and without use of equalization.},
   Key = {fds132870}
}

@article{fds174170,
   Author = {GA Johnson},
   Title = {Research into psychiatric disorder after stroke: the need
             for further studies.},
   Journal = {The Australian and New Zealand journal of
             psychiatry},
   Volume = {25},
   Number = {3},
   Pages = {358-70},
   Year = {1991},
   Month = {September},
   ISSN = {0004-8674},
   Keywords = {Cerebrovascular Disorders • Delirium, Dementia,
             Amnestic, Cognitive Disorders • Depressive Disorder
             • Follow-Up Studies • Humans • Sick Role*
             • Social Environment • psychology*},
   Abstract = {Attention is drawn to some shortcomings of previous findings
             with regard to the nature, prevalence and aetiology of
             psychiatric disorder after stroke, and in particular
             post-stroke depression. Reasons for and drawbacks of the
             emphasis on depression in studies to date are discussed.
             Inconsistencies amongst previous findings are examined and
             it is suggested that many further studies in the area are
             warranted providing methodological difficulties are
             addressed adequately.},
   Language = {eng},
   Key = {fds174170}
}

@booklet{Maki91,
   Author = {Maki, JH and Benveniste, H and MacFall, JR and Piantadosi, CA and Johnson, GA},
   Title = {MR imaging of microcirculation in rat brain: correlation
             with carbon dioxide-induced changes in blood
             flow.},
   Journal = {Journal of Magnetic Resonance Imaging},
   Volume = {1},
   Number = {6},
   Pages = {673-681},
   Year = {1991},
   Month = {November},
   ISSN = {1053-1807},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/1823172},
   Abstract = {Considerable interest has been shown in developing a
             magnetic resonance (MR) imaging technique with quantitative
             capability in the evaluation of tissue microcirculation
             ("perfusion"). In the present study, the
             flow-dephased/flow-compensated (FD/FC) technique is
             evaluated for measuring rat cerebral blood flow (CBF) under
             nearly optimal laboratory conditions. Imaging was performed
             on a 2.0-T system equipped with shielded gradient coils. Rat
             CBF was varied by manipulating arterial carbon dioxide
             pressure (PaCO2). In parallel experiments, optimized MR
             imaging studies (seven rats) were compared with laser
             Doppler flowmetry (LDF) studies (nine rats). LDF values
             showed a high degree of correlation between CBF and PaCO2,
             agreeing with results in the literature. MR imaging values,
             while correlating with PaCO2, showed considerable scatter.
             The most likely explanation is unavoidable rat motion during
             the requisite long imaging times. Because of this motion
             sensitivity, the FD/FC technique cannot provide a
             quantitative measure of CBF. It can, however, provide a
             qualitative picture.},
   Key = {Maki91}
}

@article{fds174186,
   Author = {GA Johnson},
   Title = {Psychological sequelae in stroke patients.},
   Journal = {Australian family physician},
   Volume = {20},
   Number = {11},
   Pages = {1605-7, 1610-1},
   Year = {1991},
   Month = {November},
   ISSN = {0300-8495},
   Keywords = {Anxiety Disorders • Cerebrovascular Disorders •
             Dementia • Depression • Humans • etiology
             • psychology* • therapy},
   Abstract = {The psychological sequelae of depression, anxiety and
             dementia are discussed as they affect the stroke sufferer.
             The author discusses the management options available to
             deal with these problems.},
   Language = {eng},
   Key = {fds174186}
}

@booklet{Diani91,
   Author = {A. R. Diani and D. J. Waldon and S. J. Conrad and M. J.
             Mulholland and K. L. Shull and M. F. Kubicek and G. A.
             Johnson and M. N. Brunden and A. E. Buhl},
   Title = {The opening of potassium channels - a mechanism for
             hair-growth},
   Journal = {Annals Of The New York Academy Of Sciences},
   Volume = {642},
   Pages = {504 -- 504},
   Year = {1991},
   Month = {December},
   Key = {Diani91}
}

@booklet{Veres91,
   Author = {VERES, JS and COFER, GP and JOHNSON, GA},
   Title = {DISTINGUISHING PLANT-TISSUES WITH MAGNETIC-RESONANCE
             MICROSCOPY},
   Journal = {American journal of botany},
   Volume = {78},
   Number = {12},
   Pages = {1704-1711},
   Year = {1991},
   Month = {December},
   ISSN = {0002-9122},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1991GY25000009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.2307/2444849},
   Key = {Veres91}
}

@booklet{Macfall91,
   Author = {MACFALL, JS and JOHNSON, GA and KRAMER, PJ},
   Title = {COMPARATIVE WATER-UPTAKE BY ROOTS OF DIFFERENT AGES IN
             SEEDLINGS OF LOBLOLLY-PINE (PINUS-TAEDA L)},
   Journal = {New Phytologist},
   Volume = {119},
   Number = {4},
   Pages = {551-560},
   Year = {1991},
   Month = {December},
   ISSN = {0028-646X},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1991HA17900010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1111/j.1469-8137.1991.tb01047.x},
   Key = {Macfall91}
}

@booklet{Banson92,
   Author = {M. L. Banson and G. P. Cofer and L. W. Hedlund and G. A.
             Johnson},
   Title = {Surface coil imaging of rat spine at 7.0-t},
   Journal = {Magnetic Resonance Imaging},
   Volume = {10},
   Number = {6},
   Pages = {929 -- 934},
   Year = {1992},
   Key = {Banson92}
}

@article{fds174260,
   Author = {AE Buhl and TT Kawabe and DK MacCallum and DJ Waldon and KA Knight and GA
             Johnson},
   Title = {Interaction of minoxidil with pigment in cells of the hair
             follicle: an example of binding without apparent biological
             effects.},
   Journal = {Skin pharmacology : the official journal of the Skin
             Pharmacology Society},
   Volume = {5},
   Number = {2},
   Pages = {114-23},
   Year = {1992},
   ISSN = {1011-0283},
   Keywords = {Animals • Autoradiography • Cell Differentiation
             • Cell Division • Cysteine • Melanins •
             Melanocyte-Stimulating Hormones • Mice • Mice,
             Inbred C3H • Mice, Inbred C57BL • Mice, Inbred
             Strains • Minoxidil • Pigments, Biological •
             Protein Binding • Thymidine • Vibrissae •
             drug effects • metabolism • metabolism* •
             pharmacokinetics* • pharmacology},
   Abstract = {To identify minoxidil target cells in hair follicles we
             followed the uptake of radiolabeled drug in mouse vibrissae
             follicles both in vitro and in vivo. Autoradiography showed
             that both 3H-minoxidil and 3H-minoxidil sulfate accumulated
             in the differentiating epithelial matrix cells superior to
             the dermal papilla, a distribution similar to that of
             pigment. Minoxidil localized in melanocytes, melanocyte
             processes, and areas of greater melanin concentrations
             within the epithelial cells. Although uptake of minoxidil
             was significantly less in unpigmented follicles, the drug
             stimulated proliferation and differentiation of both
             pigmented and unpigmented follicles. Labeled minoxidil bound
             to Sepia melanin and was displaced with unlabeled minoxidil
             and other electron donor drugs. This interaction with
             melanin acts as a targeting mechanism of minoxidil to
             pigmented hair follicles but has no apparent functional
             significance in hair growth. This work illustrates how
             measurement of drugs in hair may be biased by
             pigmentation.},
   Language = {eng},
   Key = {fds174260}
}

@article{fds268922,
   Author = {Banson, ML and Cofer, GP and Hedlund, LW and Johnson,
             GA},
   Title = {Surface coil imaging of rat spine at 7.0
             T.},
   Journal = {Magnetic Resonance Imaging},
   Volume = {10},
   Number = {6},
   Pages = {929-934},
   Year = {1992},
   ISSN = {0730-725X},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/1461090},
   Keywords = {Animals • Equipment Design • Magnetic Resonance
             Imaging • Rats • Rats, Sprague-Dawley • Spine
             • anatomy & histology* • instrumentation},
   Abstract = {An inductively coupled surface coil for imaging the rat
             spine at 7 T is described. This planar circular probe was
             made from microwave substrate to limit the size of the coil
             and to minimize the magnetic susceptibility. The surface
             coil was used as a single transmit/receive coil and as a
             receive-only coil with a birdcage body coil for excitation.
             The signal-to-noise ratio (SNR) of the probe was compared to
             a 5-cm birdcage coil and exceeded the birdcage coil's SNR by
             three to six times at superficial structures. The main
             advantages of the probe are an improved SNR for superficial
             structures and a simple design and use. Images with 50 x 50
             x 500 micron voxels were obtained of the rat spine with
             excellent anatomical detail.},
   Key = {fds268922}
}

@booklet{Buhl92,
   Author = {A. E. Buhl and T. T. Kawabe and D. K. Maccallum and D. J.
             Waldon and K. A. Knight and G. A. Johnson},
   Title = {Interaction of minoxidil with pigment in cells of the hair
             follicle - an example of binding without apparent biological
             effects},
   Journal = {Skin Pharmacology},
   Volume = {5},
   Number = {2},
   Pages = {114 -- 123},
   Year = {1992},
   Key = {Buhl92}
}

@booklet{Johnson92b,
   Author = {G. A. Johnson and H. S. Borovetz and J. L.
             Anderson},
   Title = {A model of pulsatile flow in a uniform deformable
             vessel},
   Journal = {Journal Of Biomechanics},
   Volume = {25},
   Number = {1},
   Pages = {91 -- 100},
   Year = {1992},
   Month = {January},
   Key = {Johnson92b}
}

@article{fds174289,
   Author = {GA Johnson and HS Borovetz and JL Anderson},
   Title = {A model of pulsatile flow in a uniform deformable
             vessel.},
   Journal = {Journal of biomechanics},
   Volume = {25},
   Number = {1},
   Pages = {91-100},
   Year = {1992},
   Month = {January},
   ISSN = {0021-9290},
   Keywords = {Animals • Blood Circulation • Blood Flow Velocity
             • Blood Pressure • Blood Vessels • Carotid
             Arteries • Dogs • Models, Cardiovascular* •
             Movement • Regional Blood Flow • Rheology •
             Stress, Mechanical • anatomy & histology •
             physiology • physiology*},
   Abstract = {Simulations of blood flow in natural and artificial conduits
             usually require large computers for numerical solution of
             the Navier-Stokes equations. Often, physical insight into
             the fluid dynamics is lost when the solution is purely
             numerical. An alternative to solving the most general form
             of the Navier-Stokes equations is described here, wherein a
             functional form of the solution is assumed in order to
             simplify the required computations. The assumed forms for
             the axial pressure gradient and velocity profile are chosen
             such that conservation of mass is satisfied for fully
             established pulsatile flow in a straight, deformable vessel.
             The resulting equations are cast in finite-difference form
             and solved explicitly. Results for the limiting cases of
             rigid wall and zero applied pressure are found to be in good
             agreement with analytical solutions. Comparison with the
             experimental results of Klanchar et al. [Circ. Res. 66,
             1624-1635 (1990]) also shows good agreement. Application of
             the model to realistic physiological parameter values
             provides insight as to the influence of the pulsatile nature
             of the flow field on wall shear development in the presence
             of a moving wall boundary. Specifically, the model
             illustrates the dependence of flow rate and shear rate on
             the amplitude of the vessel wall motion and the phase
             difference between the applied pressure difference and the
             oscillations of the vessel radius. The present model can
             serve as a useful tool for experimentalists interested in
             quantifying the magnitude and character of velocity profiles
             and shearing forces in natural and artificial biologic
             conduits.},
   Language = {eng},
   Key = {fds174289}
}

@booklet{Diani92,
   Author = {A. R. Diani and M. J. Mulholland and K. L. Shull and M. F.
             Kubicek and G. A. Johnson and H. J. Schostarez and M. N.
             Brunden and A. E. Buhl},
   Title = {Hair-growth effects of oral-administration of finasteride, a
             steroid 5-alpha-reductase inhibitor, alone and in
             combination with topical minoxidil in the balding stumptail
             macaque},
   Journal = {Journal Of Clinical Endocrinology And Metabolism},
   Volume = {74},
   Number = {2},
   Pages = {345 -- 350},
   Year = {1992},
   Month = {February},
   Key = {Diani92}
}

@booklet{Wong92,
   Author = {W. W. Wong and L. L. Clarke and G. A. Johnson and M.
             Llaurador and P. D. Klein},
   Title = {Comparison of 2 elemental-analyzer gas-isotope-ratio
             mass-spectrometer systems in the simultaneous measurement of
             c-13/c-12 ratios and carbon content in organic-samples},
   Journal = {Analytical Chemistry},
   Volume = {64},
   Number = {4},
   Pages = {354 -- 358},
   Year = {1992},
   Month = {February},
   Key = {Wong92}
}

@booklet{Banson92a,
   Author = {Banson, ML and Cofer, GP and Black, R and Johnson,
             GA},
   Title = {A probe for specimen magnetic resonance microscopy.},
   Journal = {Investigative Radiology},
   Volume = {27},
   Number = {2},
   Pages = {157-164},
   Year = {1992},
   Month = {February},
   ISSN = {0020-9996},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/1601608},
   Abstract = {One of the primary limits to spatial resolution in magnetic
             resonance (MR) microscopy is the limited signal. The purpose
             of this study is to build a radiofrequency (rf) probe for MR
             microscopy of fixed specimens at 300 MHz. The design
             criteria for the probe were (1) high sensitivity; (2) good
             rf homogeneity; (3) minimization of BO variations. All
             probes were Helmholtz pairs operating at 300 MHz. Coils were
             constructed from copper/Teflon/copper microwave substrate
             which eliminated susceptibility problems from solder and
             discrete capacitors. Signal-to-noise ratio (SNR) was
             compared with a conventional solenoid. Phantoms of agar gels
             and saline-filled tubes were used to characterize the SNR
             and homogeneity. SNR measurements of the coil pairs showed a
             marked improvement (up to 60%) over that of the reference
             solenoid. The region of homogeneity was defined as a 10%
             variation in signal intensity. This correlated with the
             coil's inner diameter. Graphs of SNR versus diameter,
             separation, and copper foil width allowed for optimization
             of the structure. Using this coil, MR microscopy is now
             possible on small, fixed specimens with pixels as small as
             20 x 20 x 30 microns. Work is currently under way exploiting
             the SNR and homogeneity provided by this probe to determine
             the degree to which MR microscopy might add to the
             pathologists' diagnostic tools.},
   Key = {Banson92a}
}

@article{fds132799,
   Author = {ML Banson and GP Cofer and R Black and GA Johnson},
   Title = {A probe for specimen magnetic resonance microscopy.},
   Journal = {Investigative radiology, UNITED STATES},
   Volume = {27},
   Number = {2},
   Pages = {157-64},
   Year = {1992},
   Month = {February},
   ISSN = {0020-9996},
   Keywords = {Copper • Equipment Design • Evaluation Studies
             • Magnetic Resonance Spectroscopy • Microscopy
             • Polytetrafluoroethylene • Sensitivity and
             Specificity • instrumentation •
             methods*},
   Abstract = {One of the primary limits to spatial resolution in magnetic
             resonance (MR) microscopy is the limited signal. The purpose
             of this study is to build a radiofrequency (rf) probe for MR
             microscopy of fixed specimens at 300 MHz. The design
             criteria for the probe were (1) high sensitivity; (2) good
             rf homogeneity; (3) minimization of BO variations. All
             probes were Helmholtz pairs operating at 300 MHz. Coils were
             constructed from copper/Teflon/copper microwave substrate
             which eliminated susceptibility problems from solder and
             discrete capacitors. Signal-to-noise ratio (SNR) was
             compared with a conventional solenoid. Phantoms of agar gels
             and saline-filled tubes were used to characterize the SNR
             and homogeneity. SNR measurements of the coil pairs showed a
             marked improvement (up to 60%) over that of the reference
             solenoid. The region of homogeneity was defined as a 10%
             variation in signal intensity. This correlated with the
             coil's inner diameter. Graphs of SNR versus diameter,
             separation, and copper foil width allowed for optimization
             of the structure. Using this coil, MR microscopy is now
             possible on small, fixed specimens with pixels as small as
             20 x 20 x 30 microns. Work is currently under way exploiting
             the SNR and homogeneity provided by this probe to determine
             the degree to which MR microscopy might add to the
             pathologists' diagnostic tools.},
   Key = {fds132799}
}

@article{fds174164,
   Author = {AR Diani and MJ Mulholland and KL Shull and MF Kubicek and GA Johnson and HJ Schostarez and MN Brunden and AE Buhl},
   Title = {Hair growth effects of oral administration of finasteride, a
             steroid 5 alpha-reductase inhibitor, alone and in
             combination with topical minoxidil in the balding stumptail
             macaque.},
   Journal = {The Journal of clinical endocrinology and
             metabolism},
   Volume = {74},
   Number = {2},
   Pages = {345-50},
   Year = {1992},
   Month = {February},
   ISSN = {0021-972X},
   Keywords = {Administration, Oral • Administration, Topical •
             Androstenes • Animals • Azasteroids •
             Chromatography, High Pressure Liquid •
             Dihydrotestosterone • Drug Interactions •
             Finasteride • Hair • Macaca • Male •
             Minoxidil • Reference Values • Testosterone •
             Testosterone 5-alpha-Reductase • administration &
             dosage • antagonists & inhibitors* • blood •
             drug effects* • pharmacology* • physiology •
             urine},
   Abstract = {A 5 alpha-reductase inhibitor, finasteride, was administered
             orally at 0.5 mg/day, alone or in combination with topical
             2% minoxidil, for 20 weeks to determine the effects on scalp
             hair growth in balding adult male stumptail macaque monkeys.
             A 7-day dose-finding study showed that both 0.5- and 2.0-mg
             doses of the drug produced a similar diminution in serum
             dihydrotestosterone (DHT) in male stumptails. Hair growth
             was evaluated by shaving and weighing scalp hair at baseline
             and at 4-week intervals during treatment to obtain
             cumulative delta hair weight (sum of the 4-week changes in
             hair weight from baseline) for the 20-week study. The
             activity of the 5 alpha-reductase enzyme was assessed by RIA
             of serum testosterone (T) and DHT at 4-week intervals. The
             combination of finasteride and minoxidil generated
             significant augmentation of hair weight (additive effect)
             compared to either drug alone. Finasteride increased hair
             weight in four of five monkeys. When the data of the one
             nonresponsive monkey were excluded, finasteride elicited a
             significant elevation in hair weight compared to topical
             vehicle alone. Minoxidil also evoked a significant increase
             in hair weight compared to vehicle alone. Serum T was
             unchanged, whereas serum DHT was significantly depressed in
             monkeys that received either finasteride or the combination
             of finasteride and minoxidil. These data suggest that
             inhibition of the conversion of T to DHT by this 5
             alpha-reductase inhibitor reverses the balding process and
             enhances hair regrowth by topical minoxidil in the male
             balding stumptail macaque.},
   Language = {eng},
   Key = {fds174164}
}

@booklet{Buhl92a,
   Author = {A. E. Buhl and D. J. Waldon and S. J. Conrad and M. J.
             Mulholland and K. L. Shull and M. F. Kubicek and G. A.
             Johnson and M. N. Brunden and K. J. Stefanski and R. G.
             Stehle and R. C. Gadwood and B. V. Kamdar and L. M. Thomasco and H. J. Schostarez and T.},
   Title = {Potassium channel conductance - a mechanism affecting
             hair-growth both invitro and invivo},
   Journal = {Journal Of Investigative Dermatology},
   Volume = {98},
   Number = {3},
   Pages = {315 -- 319},
   Year = {1992},
   Month = {March},
   Key = {Buhl92a}
}

@booklet{Johnson92a,
   Author = {G. A. Johnson and V. J. Kapoor and H. Jurgensen and D.
             Schmitz},
   Title = {Ingaas field-effect transistors with submicron gates for
             k-band applications},
   Journal = {Ieee Transactions On Microwave Theory And
             Techniques},
   Volume = {40},
   Number = {3},
   Pages = {429 -- 433},
   Year = {1992},
   Month = {March},
   Key = {Johnson92a}
}

@booklet{Smith92,
   Author = {Smith, BR and Effmann, EL and Johnson, GA},
   Title = {MR microscopy of chick embryo vasculature.},
   Journal = {Journal of Magnetic Resonance Imaging},
   Volume = {2},
   Number = {2},
   Pages = {237-240},
   Year = {1992},
   Month = {March},
   ISSN = {1053-1807},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/1562778},
   Abstract = {Six-day-old chick embryos were examined with magnetic
             resonance microscopy after vascular perfusion fixation and
             perfusion with gadolinium-doped gelatin to high-light the
             developing vascular anatomy. Gadolinium gelatin, with its
             short T1, provided a source of signal contrast within the
             vessels. The entire embryo was embedded in gelatin to
             minimize susceptibility artifacts that are prevalent at the
             high field strength (7.0 T) used. A series of single-section
             spin-echo images were acquired with various TRs to determine
             the optimal imaging sequence for a three-dimensional (3D)
             acquisition. The combination of gadolinium gelatin in the
             vascular spaces, gelatin embedding of the specimen, and
             optimal acquisition parameters yielded a 3D stack of
             high-resolution images that was readily reconstructed and
             rendered to effectively demonstrate the developing thoracic
             vessels in the embryo.},
   Key = {Smith92}
}

@article{fds174224,
   Author = {AE Buhl and DJ Waldon and SJ Conrad and MJ Mulholland and KL Shull and MF
             Kubicek, GA Johnson and MN Brunden and KJ Stefanski and RG
             Stehle},
   Title = {Potassium channel conductance: a mechanism affecting hair
             growth both in vitro and in vivo.},
   Journal = {The Journal of investigative dermatology},
   Volume = {98},
   Number = {3},
   Pages = {315-9},
   Year = {1992},
   Month = {March},
   ISSN = {0022-202X},
   Keywords = {Animals • Benzopyrans • Cells, Cultured •
             Cromakalim • Hair • Mice • Mice, Inbred C3H
             • Mice, Inbred C57BL • Minoxidil • Potassium
             Channels • Pyrroles • growth & development* •
             pharmacology • physiology*},
   Abstract = {The opening of intracellular potassium channels has been
             suggested as a mechanism regulating hair growth. Enhancing
             the flux of potassium ions is a mechanism shared by several
             structurally diverse antihypertensive agents including
             minoxidil sulfate (the active metabolite of minoxidil),
             pinacidil, P-1075 (a potent pinacidil analog), RP-49,356,
             diazoxide, cromakalim, and nicorandil. Of these drugs,
             minoxidil, pinacidil, and diazoxide have been reported to
             elicit hypertrichosis in humans. This potassium channel
             hypothesis was examined by testing these drugs for effects
             on hair growth both in vitro and in vivo. For the in vitro
             studies, mouse vibrissae follicles were cultured for 3 d
             with drug and the effects on hair growth were measured by
             metabolic labeling. All drugs, except diazoxide, enhanced
             cysteine incorporation into the hair shafts of the cultured
             vibrissae. Diazoxide was poorly soluble and thus was tested
             only at low doses. Minoxidil, P-1075, cromakalim, and
             RP-49,356 were also evaluated in vivo by measuring hair
             growth effects in balding stumptail macaque monkeys. The
             drugs were administered topically to defined sites on
             balding scalps once per day for 4-5 months and the amount of
             hair grown was determined by monthly measurements of shaved
             hair weight. Three of the drugs produced significant
             increases in hair weight whereas, the RP-49,356 had no
             effect. These studies provide correlative evidence that the
             opening of potassium channels is an important regulatory
             mechanism for hair growth. This provides the impetus for
             further studies on this potentially important mechanism
             affecting hair biology.},
   Language = {eng},
   Key = {fds174224}
}

@booklet{Johnson92,
   Author = {G. A. Johnson and C. A. Baker and K. A. Knight},
   Title = {Minoxidil sulfotransferase, a marker of human keratinocyte
             differentiation},
   Journal = {Journal Of Investigative Dermatology},
   Volume = {98},
   Number = {5},
   Pages = {730 -- 733},
   Year = {1992},
   Month = {May},
   Key = {Johnson92}
}

@booklet{Benveniste92,
   Author = {Benveniste, H and Hedlund, LW and Johnson, GA},
   Title = {Mechanism of detection of acute cerebral ischemia in rats by
             diffusion-weighted magnetic resonance microscopy.},
   Journal = {Stroke},
   Volume = {23},
   Number = {5},
   Pages = {746-754},
   Year = {1992},
   Month = {May},
   ISSN = {0039-2499},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/1374575},
   Abstract = {BACKGROUND AND PURPOSE: The aim of this study was to measure
             apparent diffusion coefficients in rat brain tissue exposed
             to ouabain, glutamate, and N-methyl-D-aspartate and to
             compare them with apparent diffusion coefficients found in
             acute cerebral ischemia. METHODS: The apparent diffusion
             coefficient was measured using magnetic resonance microscopy
             in four groups of Sprague-Dawley rats after occlusion of the
             right middle cerebral artery and ipsilateral common carotid
             artery (n = 7), after ouabain exposure (n = 6), during
             glutamate exposure (n = 7), or during N-methyl-D-aspartate
             exposure (n = 3). Ouabain, glutamate, and
             N-methyl-D-aspartate were applied via an intracerebrally
             implanted microdialysis membrane. RESULTS: Three hours after
             the induction of focal cerebral ischemia, a 33% reduction in
             the apparent diffusion coefficient was observed in the right
             dorsolateral corpus striatum and olfactory cortex. After
             ouabain exposure, reductions in the apparent diffusion
             coefficient were observed within a 1,500-microns radius of
             the microdialysis membrane. Quantitative analysis revealed
             that apparent diffusion coefficient values in ischemic and
             ouabain-exposed tissue fell within the same range. Glutamate
             and N-methyl-D-aspartate reduced the brain tissue apparent
             diffusion coefficient by 35% and 40%, respectively.
             CONCLUSIONS: On the basis of these findings, we conclude
             that ischemia-induced apparent diffusion coefficient
             reductions are likely caused by a shift of extracellular to
             intracellular water.},
   Key = {Benveniste92}
}

@article{fds132804,
   Author = {H Benveniste and LW Hedlund and GA Johnson},
   Title = {Mechanism of detection of acute cerebral ischemia in rats by
             diffusion-weighted magnetic resonance microscopy.},
   Journal = {Stroke; a journal of cerebral circulation, UNITED
             STATES},
   Volume = {23},
   Number = {5},
   Pages = {746-54},
   Year = {1992},
   Month = {May},
   ISSN = {0039-2499},
   Keywords = {Acute Disease • Animals • Brain • Brain
             Ischemia • Diffusion • Female • Glutamates
             • Glutamic Acid • Magnetic Resonance Imaging
             • N-Methylaspartate • Ouabain • Rats •
             Rats, Inbred Strains • Staining and Labeling •
             diagnosis* • drug effects • metabolism •
             methods* • pharmacology},
   Abstract = {BACKGROUND AND PURPOSE: The aim of this study was to measure
             apparent diffusion coefficients in rat brain tissue exposed
             to ouabain, glutamate, and N-methyl-D-aspartate and to
             compare them with apparent diffusion coefficients found in
             acute cerebral ischemia. METHODS: The apparent diffusion
             coefficient was measured using magnetic resonance microscopy
             in four groups of Sprague-Dawley rats after occlusion of the
             right middle cerebral artery and ipsilateral common carotid
             artery (n = 7), after ouabain exposure (n = 6), during
             glutamate exposure (n = 7), or during N-methyl-D-aspartate
             exposure (n = 3). Ouabain, glutamate, and
             N-methyl-D-aspartate were applied via an intracerebrally
             implanted microdialysis membrane. RESULTS: Three hours after
             the induction of focal cerebral ischemia, a 33% reduction in
             the apparent diffusion coefficient was observed in the right
             dorsolateral corpus striatum and olfactory cortex. After
             ouabain exposure, reductions in the apparent diffusion
             coefficient were observed within a 1,500-microns radius of
             the microdialysis membrane. Quantitative analysis revealed
             that apparent diffusion coefficient values in ischemic and
             ouabain-exposed tissue fell within the same range. Glutamate
             and N-methyl-D-aspartate reduced the brain tissue apparent
             diffusion coefficient by 35% and 40%, respectively.
             CONCLUSIONS: On the basis of these findings, we conclude
             that ischemia-induced apparent diffusion coefficient
             reductions are likely caused by a shift of extracellular to
             intracellular water.},
   Key = {fds132804}
}

@article{fds174244,
   Author = {GA Johnson and CA Baker and KA Knight},
   Title = {Minoxidil sulfotransferase, a marker of human keratinocyte
             differentiation.},
   Journal = {The Journal of investigative dermatology},
   Volume = {98},
   Number = {5},
   Pages = {730-3},
   Year = {1992},
   Month = {May},
   ISSN = {0022-202X},
   Keywords = {Biological Markers • Calcium • Cell
             Differentiation • Enzyme Induction • Humans •
             Keratinocytes • Sulfotransferases • Time Factors
             • Transglutaminases • cytology* • enzymology
             • metabolism • pharmacology •
             pharmacology*},
   Abstract = {The sulfation of minoxidil is catalyzed by a
             sulfotransferase activity in a number of tissues including
             skin. To investigate further the nature of the minoxidil
             sulfotransferase activity in epithelial tissue and to
             compare this activity to that of cholesterol
             sulfotransferase, which has already been shown to be induced
             during the differentiation of epithelial cells, we cultured
             normal human epidermal keratinocytes in a keratinocyte
             growth medium for 4 d, after which the media were replaced
             with either the same growth media or media with increasing
             Ca++ concentrations. Cholesterol sulfotransferase, minoxidil
             sulfotransferase, and transglutaminase were determined
             during the differentiation of the cells in the three media.
             Time-activity curves that suggested two different
             sulfotransferase activities were induced during the
             differentiation process. U-77581, a competitive inhibitor of
             minoxidil sulfotransferase activity, inhibited the sulfation
             of minoxidil sulfotransferase activity in the keratinocyte
             homogenates, but it did not inhibit the sulfation of
             cholesterol. These data indicate that at least two
             sulfotransferase activities are induced during the
             differentiation of epithelial keratinocytes and minoxidil
             sulfotransferase is an early marker of that
             differentiation.},
   Language = {eng},
   Key = {fds174244}
}

@booklet{Brouwer92,
   Author = {Brouwer, M and Engel, DW and Bonaventura, J and Johnson,
             GA},
   Title = {In vivo magnetic resonance imaging of the blue crab,
             Callinectes sapidus: effect of cadmium accumulation in
             tissues on proton relaxation properties.},
   Journal = {Journal of Experimental Zoology},
   Volume = {263},
   Number = {1},
   Pages = {32-40},
   Year = {1992},
   Month = {August},
   ISSN = {0022-104X},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/1645119},
   Abstract = {Nuclear magnetic resonance imaging (MRI) has been used to
             visualize the internal anatomy of a living blue crab. The
             resolution obtained in these studies was sufficient to
             distinguish individual organs by the differences in their
             proton densities and proton relaxation properties. T1
             (spin-lattice relaxation time)-weighted imaging revealed the
             lipid-rich nature of the hepatopancreas and gonadal tissue.
             To evaluate the effect of metal-induced stress on the
             different organs, crabs were exposed to elevated levels of
             cadmium in their diet, which resulted in increased
             concentrations of both cadmium and copper in the
             hepatopancreas. The spin-spin relaxation time, T2, of mobile
             protons in the metal-exposed tissue was significantly
             greater than T2 in the control tissues. These measurements
             suggest that the excess copper in the exposed tissues was
             diamagnetic [Cu(I)], since the presence of paramagnetic
             copper [Cu(II)] would result in a decrease of observed T2
             values. We hypothesize that the increased T2 value is a
             reflection of increased free water in the hepatopancreas.
             These studies show that magnetic resonance imaging is an
             important nondestructive tool for the study of morphological
             and physiological changes that occur in marine invertebrates
             in response to anthropogenic and natural
             stresses.},
   Doi = {10.1002/jez.1402630105},
   Key = {Brouwer92}
}

@article{fds132893,
   Author = {M Brouwer and DW Engel and J Bonaventura and GA Johnson},
   Title = {In vivo magnetic resonance imaging of the blue crab,
             Callinectes sapidus: effect of cadmium accumulation in
             tissues on proton relaxation properties.},
   Journal = {The Journal of experimental zoology, UNITED
             STATES},
   Volume = {263},
   Number = {1},
   Pages = {32-40},
   Year = {1992},
   Month = {August},
   ISSN = {0022-104X},
   Keywords = {Animals • Brachyura • Cadmium • Copper •
             Diet • Liver • Magnetic Resonance Imaging* •
             Male • Organ Specificity • Pancreas • Trace
             Elements • administration & dosage • analysis
             • anatomy & histology • anatomy & histology*
             • metabolism},
   Abstract = {Nuclear magnetic resonance imaging (MRI) has been used to
             visualize the internal anatomy of a living blue crab. The
             resolution obtained in these studies was sufficient to
             distinguish individual organs by the differences in their
             proton densities and proton relaxation properties. T1
             (spin-lattice relaxation time)-weighted imaging revealed the
             lipid-rich nature of the hepatopancreas and gonadal tissue.
             To evaluate the effect of metal-induced stress on the
             different organs, crabs were exposed to elevated levels of
             cadmium in their diet, which resulted in increased
             concentrations of both cadmium and copper in the
             hepatopancreas. The spin-spin relaxation time, T2, of mobile
             protons in the metal-exposed tissue was significantly
             greater than T2 in the control tissues. These measurements
             suggest that the excess copper in the exposed tissues was
             diamagnetic [Cu(I)], since the presence of paramagnetic
             copper [Cu(II)] would result in a decrease of observed T2
             values. We hypothesize that the increased T2 value is a
             reflection of increased free water in the hepatopancreas.
             These studies show that magnetic resonance imaging is an
             important nondestructive tool for the study of morphological
             and physiological changes that occur in marine invertebrates
             in response to anthropogenic and natural
             stresses.},
   Key = {fds132893}
}

@booklet{Lee92,
   Author = {D. H. Lee and G. A. Johnson and M. K. Park},
   Title = {Oscillometric blood-pressure in the arm, thigh and calf in
             healthy-children and those with aortic coarctation},
   Journal = {Clinical Research},
   Volume = {40},
   Number = {4},
   Pages = {A834 -- A834},
   Year = {1992},
   Month = {December},
   Key = {Lee92}
}

@booklet{Macfall92,
   Author = {Macfall, JS and Pfeffer, PE and Rolin, DB and Macfall, JR and Johnson,
             GA},
   Title = {Observation of the Oxygen Diffusion Barrier in Soybean
             (Glycine max) Nodules with Magnetic Resonance
             Microscopy.},
   Journal = {Plant physiology},
   Volume = {100},
   Number = {4},
   Pages = {1691-1697},
   Year = {1992},
   Month = {December},
   ISSN = {0032-0889},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/16653185},
   Abstract = {The effects of selected gas perfusion treatments on the
             spinlattice relaxation times (T(1)) of the soybean (Glycine
             max) nodule cortex and inner nodule tissue were studied with
             (1)H high resolution magnetic resonance microscopy. Three
             gas treatments were used: (a) perfusion with O(2) followed
             by N(2); (b) O(2) followed by O(2); and (c) air followed by
             N(2). Soybean plants with intact attached nodules were
             placed into the bore of a superconducting magnet and a
             selected root with nodules was perfused with the gas of
             interest. Magnetic resonance images were acquired with
             repetition times from 50 to 3200 ms. The method of partial
             saturation was used to calculate T(1) times on selected
             regions of the image. Calculated images based on T(1) showed
             longer T(1) values in the cortex than in the inner nodule
             during all of the gas perfusions. When nodules were perfused
             with O(2)-O(2), there was no significant change in the T(1)
             of the nodule between the two gas treatments. When the
             nodule was perfused with O(2)-N(2) or air-N(2), however, the
             T(1) of both the cortex and inner nodule increased. In these
             experiments, the increase in T(1) of the cortex was 2- to
             3-fold greater than the increase observed in the inner
             nodule. A similar change in T(1) was found in detached live
             nodules, but there was no change in T(1) with selective gas
             perfusion of detached dead nodules. These observations
             suggest that cortical cells respond differently to selected
             gas perfusion than the inner nodule, with the boundary of
             T(1) change sharply delineated at the interface of the inner
             nodule and the inner cortex.},
   Key = {Macfall92}
}

@article{fds157082,
   Author = {JS Macfall and PE Pfeffer and DB Rolin, JR Macfall and GA
             Johnson},
   Title = {Observation of the Oxygen Diffusion Barrier in Soybean
             (Glycine max) Nodules with Magnetic Resonance
             Microscopy.},
   Journal = {Plant physiology},
   Volume = {100},
   Number = {4},
   Pages = {1691-1697},
   Year = {1992},
   Month = {December},
   ISSN = {0032-0889},
   Abstract = {The effects of selected gas perfusion treatments on the
             spinlattice relaxation times (T(1)) of the soybean (Glycine
             max) nodule cortex and inner nodule tissue were studied with
             (1)H high resolution magnetic resonance microscopy. Three
             gas treatments were used: (a) perfusion with O(2) followed
             by N(2); (b) O(2) followed by O(2); and (c) air followed by
             N(2). Soybean plants with intact attached nodules were
             placed into the bore of a superconducting magnet and a
             selected root with nodules was perfused with the gas of
             interest. Magnetic resonance images were acquired with
             repetition times from 50 to 3200 ms. The method of partial
             saturation was used to calculate T(1) times on selected
             regions of the image. Calculated images based on T(1) showed
             longer T(1) values in the cortex than in the inner nodule
             during all of the gas perfusions. When nodules were perfused
             with O(2)-O(2), there was no significant change in the T(1)
             of the nodule between the two gas treatments. When the
             nodule was perfused with O(2)-N(2) or air-N(2), however, the
             T(1) of both the cortex and inner nodule increased. In these
             experiments, the increase in T(1) of the cortex was 2- to
             3-fold greater than the increase observed in the inner
             nodule. A similar change in T(1) was found in detached live
             nodules, but there was no change in T(1) with selective gas
             perfusion of detached dead nodules. These observations
             suggest that cortical cells respond differently to selected
             gas perfusion than the inner nodule, with the boundary of
             T(1) change sharply delineated at the interface of the inner
             nodule and the inner cortex.},
   Key = {fds157082}
}

@booklet{Johnson93a,
   Author = {G. A. Johnson and M. S. Defelice and Z. R.
             Helsel},
   Title = {Cover crop management and weed-control in corn
             (zea-mays)},
   Journal = {Weed Technology},
   Volume = {7},
   Number = {2},
   Pages = {425 -- 430},
   Year = {1993},
   Key = {Johnson93a}
}

@article{fds268798,
   Author = {Smith, WM and Hsu, JCM and Johnson, GA and Reimer, KA and Ideker,
             RE},
   Title = {Detection of infarcted tissue the heart by magnetic
             resonance imaging},
   Journal = {Proceedings of the Annual Conference on Engineering in
             Medicine and Biology},
   Volume = {15},
   Number = {pt 1},
   Pages = {485-486},
   Year = {1993},
   Abstract = {Morphological analysis of myocardial infarct structure has
             demonstrated that there is probably an anatomical basis for
             the induction and maintenance of ventricular tachycardia.
             The further study of this phenomenon requires an efficient,
             accurate method for quantitative analysis of pathological
             anatomy. We have evaluated the ability of magnetic resonance
             imaging to distinguish between normal and infarcted tissue
             in formalin-fixed human hearts with distant myocardial
             infarctions.},
   Key = {fds268798}
}

@article{fds268744,
   Author = {BENVENISTE, H and JOHNSON, GA and KOZNIEWSKA, E and MAIESE, K and NARITOMI, H and POVLISHOCK, JT and HOSSMANN, KA},
   Title = {EXCITOTOXICITY AND ISCHEMIA IN THE RAT-BRAIN STUDIED IN-VIVO
             WITH HIGH-RESOLUTION MAGNETIC-RESONANCE-IMAGING},
   Journal = {International Congress Series},
   Volume = {1031},
   Pages = {369-376},
   Year = {1993},
   ISBN = {0-444-89669-4},
   ISSN = {0531-5131},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993BZ68Q00043&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {fds268744}
}

@booklet{Anderson93,
   Author = {C. S. Anderson and K. D. Jamrozik and P. W. Burvill and T.
             M. H. Chakera and G. A. Johnson and E. G.
             Stewartwynne},
   Title = {Ascertaining the true incidence of stroke - experience from
             the perth community stroke study, 1989-1990},
   Journal = {Medical Journal Of Australia},
   Volume = {158},
   Number = {2},
   Pages = {80 -- 84},
   Year = {1993},
   Month = {January},
   Key = {Anderson93}
}

@booklet{Waldon93a,
   Author = {D. J. Waldon and M. F. Kubicek and G. A. Johnson and A. E.
             Buhl},
   Title = {A hplc-based chloramphenicol acetyltransferase assay for
             assessing hair-growth - comparison of the sensitivity of uv
             and fluorescence detection},
   Journal = {European Journal Of Clinical Chemistry And Clinical
             Biochemistry},
   Volume = {31},
   Number = {1},
   Pages = {41 -- 45},
   Year = {1993},
   Month = {January},
   Key = {Waldon93a}
}

@booklet{Meisheri93,
   Author = {K. D. Meisheri and G. A. Johnson and L. Puddington},
   Title = {Enzymatic and nonenzymatic sulfation mechanisms in the
             biological actions of minoxidil},
   Journal = {Biochemical Pharmacology},
   Volume = {45},
   Number = {2},
   Pages = {271 -- 279},
   Year = {1993},
   Month = {January},
   Key = {Meisheri93}
}

@booklet{Anderson93a,
   Author = {C. S. Anderson and K. D. Jamrozik and P. W. Burvill and T.
             M. H. Chakera and G. A. Johnson and E. G.
             Stewartwynne},
   Title = {Determining the incidence of different subtypes of stroke -
             results from the perth community stroke study,
             1989-1990},
   Journal = {Medical Journal Of Australia},
   Volume = {158},
   Number = {2},
   Pages = {85 -- 89},
   Year = {1993},
   Month = {January},
   Key = {Anderson93a}
}

@booklet{Huesgen93,
   Author = {Huesgen, CT and Burger, PC and Crain, BJ and Johnson,
             GA},
   Title = {In vitro MR microscopy of the hippocampus in Alzheimer's
             disease.},
   Journal = {Neurology},
   Volume = {43},
   Number = {1},
   Pages = {145-152},
   Year = {1993},
   Month = {January},
   ISSN = {0028-3878},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8423879},
   Abstract = {We used MR microscopy at 7 tesla to identify the anatomy of
             the degenerating hippocampus in Alzheimer's disease (AD),
             which we then correlated with the histopathologic findings
             in the same specimens. The specimens studied were resected
             postmortem from 13 patients with confirmed AD and from nine
             age-matched controls. We imaged the specimens in the coronal
             plane using either three-dimensional Fourier encoding or
             single-slice Carr, Purcell, Meiboom, Gill (CPMG) spin echo
             sequences. On all specimens imaged with the CPMG pulse
             sequence, we calculated the T2 relaxation times for
             subfields within the hippocampus. Histologic sections were
             taken from each specimen and compared with the corresponding
             MR image. Using histologic boundaries, we quantified the
             number of neuritic plaques and neurofibrillary tangles in
             each hippocampal subfield. We measured the area,
             morphometric characteristics, and width of identifiable
             signal variant regions on each image and compared these
             measurements with the histopathologic findings. The mean
             cross-sectional area of the hippocampus in AD was decreased
             by 31% compared with the control group. This atrophy was
             highly correlated with tangle counts within the hippocampus,
             but not with plaque counts. The width of the gray matter in
             hippocampal area CA1, as identified by MR, correlated with
             the total area of the hippocampus. An age-related decrease
             in the size of a low-signal region that corresponds
             histologically to input projections comprising part of the
             perforant pathway was identified. Measurements of the T2
             relaxation times of hippocampal subfields showed little
             regional variability and were not accurate indicators of
             disease presence or severity (p > 0.05).},
   Key = {Huesgen93}
}

@booklet{Gewalt93,
   Author = {Gewalt, SL and Glover, GH and Hedlund, LW and Cofer, GP and MacFall, JR and Johnson, GA},
   Title = {MR microscopy of the rat lung using projection
             reconstruction.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {29},
   Number = {1},
   Pages = {99-106},
   Year = {1993},
   Month = {January},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8419748},
   Abstract = {Projection reconstruction has been implemented with
             self-refocused selection pulses on a small bore, 2.0 T MR
             microscope, to allow imaging of lung parenchyma. Scan
             synchronous ventilation and cardiac gating have been
             integrated with the sequence to minimize motion artifacts. A
             systematic survey of the pulse sequence parameters has been
             undertaken in conjunction with the biological gating
             parameters to optimize resolution and signal-to-noise (SNR).
             The resulting projection images with effective echo time of
             < 300 microseconds allow definition of lung parenchyma with
             an SNR improvement of approximately 15 x over a more
             conventional 2DFT short echo gradient sequence.},
   Key = {Gewalt93}
}

@article{fds132788,
   Author = {CT Huesgen and PC Burger and BJ Crain and GA Johnson},
   Title = {In vitro MR microscopy of the hippocampus in Alzheimer's
             disease.},
   Journal = {Neurology, UNITED STATES},
   Volume = {43},
   Number = {1},
   Pages = {145-52},
   Year = {1993},
   Month = {January},
   ISSN = {0028-3878},
   Keywords = {Aged • Aged, 80 and over • Alzheimer Disease
             • Fourier Analysis • Hippocampus • Humans
             • Magnetic Resonance Imaging* • Middle Aged •
             Neurofibrillary Tangles • pathology •
             pathology*},
   Abstract = {We used MR microscopy at 7 tesla to identify the anatomy of
             the degenerating hippocampus in Alzheimer's disease (AD),
             which we then correlated with the histopathologic findings
             in the same specimens. The specimens studied were resected
             postmortem from 13 patients with confirmed AD and from nine
             age-matched controls. We imaged the specimens in the coronal
             plane using either three-dimensional Fourier encoding or
             single-slice Carr, Purcell, Meiboom, Gill (CPMG) spin echo
             sequences. On all specimens imaged with the CPMG pulse
             sequence, we calculated the T2 relaxation times for
             subfields within the hippocampus. Histologic sections were
             taken from each specimen and compared with the corresponding
             MR image. Using histologic boundaries, we quantified the
             number of neuritic plaques and neurofibrillary tangles in
             each hippocampal subfield. We measured the area,
             morphometric characteristics, and width of identifiable
             signal variant regions on each image and compared these
             measurements with the histopathologic findings. The mean
             cross-sectional area of the hippocampus in AD was decreased
             by 31% compared with the control group. This atrophy was
             highly correlated with tangle counts within the hippocampus,
             but not with plaque counts. The width of the gray matter in
             hippocampal area CA1, as identified by MR, correlated with
             the total area of the hippocampus. An age-related decrease
             in the size of a low-signal region that corresponds
             histologically to input projections comprising part of the
             perforant pathway was identified. Measurements of the T2
             relaxation times of hippocampal subfields showed little
             regional variability and were not accurate indicators of
             disease presence or severity (p > 0.05).},
   Key = {fds132788}
}

@article{fds132886,
   Author = {SL Gewalt and GH Glover and LW Hedlund and GP Cofer, JR MacFall and GA
             Johnson},
   Title = {MR microscopy of the rat lung using projection
             reconstruction.},
   Journal = {Magnetic resonance in medicine : official journal of the
             Society of Magnetic Resonance in Medicine / Society of
             Magnetic Resonance in Medicine, UNITED STATES},
   Volume = {29},
   Number = {1},
   Pages = {99-106},
   Year = {1993},
   Month = {January},
   ISSN = {0740-3194},
   Keywords = {Animals • Female • Lung • Magnetic Resonance
             Imaging* • Microscopy • Rats • Rats,
             Sprague-Dawley • cytology*},
   Abstract = {Projection reconstruction has been implemented with
             self-refocused selection pulses on a small bore, 2.0 T MR
             microscope, to allow imaging of lung parenchyma. Scan
             synchronous ventilation and cardiac gating have been
             integrated with the sequence to minimize motion artifacts. A
             systematic survey of the pulse sequence parameters has been
             undertaken in conjunction with the biological gating
             parameters to optimize resolution and signal-to-noise (SNR).
             The resulting projection images with effective echo time of
             < 300 microseconds allow definition of lung parenchyma with
             an SNR improvement of approximately 15 x over a more
             conventional 2DFT short echo gradient sequence.},
   Key = {fds132886}
}

@article{fds132898,
   Author = {KD Meisheri and GA Johnson and L Puddington},
   Title = {Enzymatic and non-enzymatic sulfation mechanisms in the
             biological actions of minoxidil.},
   Journal = {Biochemical pharmacology, ENGLAND},
   Volume = {45},
   Number = {2},
   Pages = {271-9},
   Year = {1993},
   Month = {January},
   ISSN = {0006-2952},
   Keywords = {Animals • Biotransformation • Humans •
             Minoxidil • Muscle, Smooth, Vascular • Potassium
             Channels • Proteins • Sulfotransferases •
             Triazines • Vasodilation • drug effects •
             metabolism • metabolism* • pharmacokinetics •
             pharmacology},
   Key = {fds132898}
}

@article{fds174077,
   Author = {DJ Waldon and MF Kubicek and GA Johnson and AE Buhl},
   Title = {A HPLC-based chloramphenicol acetyltransferase assay for
             assessing hair growth: comparison of the sensitivity of UV
             and fluorescence detection.},
   Journal = {European journal of clinical chemistry and clinical
             biochemistry : journal of the Forum of European Clinical
             Chemistry Societies},
   Volume = {31},
   Number = {1},
   Pages = {41-5},
   Year = {1993},
   Month = {January},
   ISSN = {0939-4974},
   Keywords = {Animals • Chloramphenicol O-Acetyltransferase •
             Chromatography, High Pressure Liquid* • Culture
             Techniques • Gene Expression • Hair •
             Keratins • Mice • Mice, Transgenic • Promoter
             Regions, Genetic • Sensitivity and Specificity •
             Spectrometry, Fluorescence • Spectrophotometry,
             Ultraviolet • analysis* • genetics •
             genetics* • growth & development*},
   Abstract = {In our attempt to measure hair growth by hair-specific
             markers, we used transgenic mice to express the
             chloramphenicol acetyltransferase gene under the control of
             an ultrahigh sulphur keratin gene promoter. To quantitate
             expression of the keratin gene, we required a
             chloramphenicol acetyltransferase assay which could measure
             enzyme activity in a single follicle and also could be used
             to assay a large number of samples without loss of
             sensitivity. We achieved this objective by utilizing a
             fluorescent substrate for chloramphenicol acetyltransferase.
             With HPLC-fluorescence detection, this substrate provides a
             sensitivity of less than 1 x 10(-13) mol, which is 1000
             times greater than that achievable with HPLC-UV detection in
             cultured follicles. Further, the assay was automated to
             facilitate the analysis of more than 100 samples/day. It
             should be possible to apply this fluorescent assay to a
             number of cell or tissue studies.},
   Language = {eng},
   Key = {fds174077}
}

@article{fds174290,
   Author = {CS Anderson and KD Jamrozik and PW Burvill and TM Chakera and GA
             Johnson, EG Stewart-Wynne},
   Title = {Ascertaining the true incidence of stroke: experience from
             the Perth Community Stroke Study, 1989-1990.},
   Journal = {The Medical journal of Australia},
   Volume = {158},
   Number = {2},
   Pages = {80-4},
   Year = {1993},
   Month = {January},
   ISSN = {0025-729X},
   Keywords = {Adolescent • Adult • Age Factors • Aged
             • Aged, 80 and over • Cerebrovascular Disorders
             • Confidence Intervals • Female • Follow-Up
             Studies • Humans • Incidence • Ischemic
             Attack, Transient • Male • Middle Aged • Sex
             Factors • Western Australia • epidemiology •
             epidemiology* • mortality},
   Abstract = {OBJECTIVE: To determine the age and sex specific incidence,
             and case fatality of stroke in Perth, Western Australia.
             DESIGN AND SETTING: A population-based descriptive
             epidemiological study. SUBJECTS: All residents of a
             geographically defined segment of the Perth metropolitan
             area (population 138,708) who had a stroke or transient
             ischaemic attack between 20 February 1989 and 19 August
             1990, inclusive. MAIN OUTCOME MEASURES: Definite acute
             "first-ever-in-a-lifetime" (first-ever) and recurrent stroke
             classified according to standard definitions and criteria.
             RESULTS: During the 18-month study period, 536 stroke events
             occurred among 492 patients, 69% of which were first-ever
             strokes. The crude annual event rate for all strokes was 258
             (95% confidence interval 231-285) per 100,000, and the
             overall case fatality at 28 days was 24% (95% CI, 20%-28%).
             The crude annual incidence for first-ever strokes was 178
             (95% CI, 156-200) per 100,000; 189 (95% CI, 157-221) per
             100,000 in males and 166 (95% CI, 136-196) per 100,000 in
             females. The corresponding rates, age-adjusted to the
             "world" population, were 132 (95% CI, 109-155) for males and
             77 (95% CI, 60-94) for females. CONCLUSIONS: In contrast to
             mortality rates for ischaemic heart disease, the incidence
             of stroke in Australia appears little different from that
             for several other Western countries. For both males and
             females the incidence of stroke rises exponentially with
             increasing age. Although the sex-dependent difference in the
             risk of stroke is greatest in middle age, males are at
             greater risk of stroke even among the most elderly. To
             determine the incidence of stroke accurately,
             population-based studies of stroke need exhaustive and
             overlapping sources of case ascertainment. If only cases
             admitted to hospital had been used, we would have
             underestimated the rate of stroke among the most elderly by
             almost 40%. We estimate that approximately 37,000 people,
             about 50% of whom are over the age of 75, suffer a stroke
             each year in Australia.},
   Language = {eng},
   Key = {fds174290}
}

@article{fds174307,
   Author = {CS Anderson and KD Jamrozik and PW Burvill and TM Chakera and GA
             Johnson, EG Stewart-Wynne},
   Title = {Determining the incidence of different subtypes of stroke:
             results from the Perth Community Stroke Study,
             1989-1990.},
   Journal = {The Medical journal of Australia},
   Volume = {158},
   Number = {2},
   Pages = {85-9},
   Year = {1993},
   Month = {January},
   ISSN = {0025-729X},
   Keywords = {Adult • Aged • Aged, 80 and over • Cerebral
             Hemorrhage • Cerebral Infarction • Cerebrovascular
             Disorders • Female • Humans • Intracranial
             Embolism and Thrombosis • Male • Middle Aged
             • Western Australia • classification* •
             epidemiology • epidemiology*},
   Abstract = {OBJECTIVE: To determine the incidence and case fatality of
             seven distinct subtypes of stroke in Perth, Western
             Australia. DESIGN AND SETTING: A population-based
             descriptive epidemiological study. SUBJECTS: All residents
             of a geographically defined segment of the Perth
             metropolitan area (estimated population 138,708 persons) who
             had a stroke or transient ischaemic attack between 20
             February 1989 and 19 August 1990, inclusive. MAIN OUTCOME
             MEASURES: The following subtypes of stroke were classified
             according to standard clinical, radiological and
             pathological criteria: types of cerebral infarction, namely,
             large artery (thrombotic) occlusive infarction (LAOI),
             cerebral embolic infarction (EMBI), lacunar infarction
             (LACI) and boundary zone infarction (BZI); primary
             intracerebral haemorrhage (PICH); subarachnoid haemorrhage
             (SAH); and stroke of undetermined cause. RESULTS: Over the
             18-month study period 536 stroke events were registered, of
             which 86% (95% confidence interval, 83%-89%) had a defined
             "pathological" diagnosis on the basis of computed
             tomographic scanning, magnetic resonance imaging or
             necropsy. Cerebral infarction accounted for 71% of cases
             (95% CI, 68%-75%), PICH 11% (95% CI, 9%-14%) and SAH 4% (95%
             CI, 2%-5%). The 382 cases of cerebral infarction included
             LAOI (in approximately 71%), EMBI (15%), LACI (10%) and BZI
             (5%). While the incidence of all subtypes of stroke
             increased with age, there were age and sex differences in
             their proportional frequency, management and prognosis:
             patients with PICH, SAH and EMBI were more likely to be
             admitted to hospital, and these conditions carried the
             highest early case fatality. Over all, the 28-day case
             fatality was 24% (95% CI, 20%-28%), but varied from 0 for
             LACI and BZI, to 37% (95% CI, 15%-59%) for SAH and 35% (CI,
             23%-47%) for PICH. CONCLUSIONS: In this study, we found
             considerable differences in incidence rates, the effect of
             age and sex on incidence rates, and prognosis for the
             different subtypes of stroke. Hospital-based studies are
             likely to be selectively biased by emphasising strokes that
             are severe and require admission to hospital. These data
             have important implications in the design and evaluation of
             clinical trials of therapy for stroke.},
   Language = {eng},
   Key = {fds174307}
}

@article{fds132865,
   Author = {RD Black and TA Early and PB Roemer and OM Mueller and A Mogro-Campero and LG Turner and GA Johnson},
   Title = {A high-temperature superconducting receiver for nuclear
             magnetic resonance microscopy.},
   Journal = {Science (New York, N.Y.), UNITED STATES},
   Volume = {259},
   Number = {5096},
   Pages = {793-5},
   Year = {1993},
   Month = {February},
   ISSN = {0036-8075},
   Keywords = {Animals • Humans • Magnetic Resonance Spectroscopy
             • Models, Theoretical • instrumentation* •
             methods},
   Abstract = {A high-temperature superconducting-receiver system for use
             in nuclear magnetic resonance (NMR) microscopy is described.
             The scaling behavior of sources of sample and receiver-coil
             noise is analyzed, and it is demonstrated that Johnson, or
             thermal, noise in the receiver coil is the factor that
             limits resolution. The behavior of superconductors in the
             environment of an NMR experiment is examined, and a
             prototypical system for imaging biological specimens is
             discussed. Preliminary spin-echo images are shown, and the
             ultimate limits of the signal-to-noise ratio of the probe
             are investigated.},
   Key = {fds132865}
}

@booklet{Black93,
   Author = {Black, RD and Early, TA and Roemer, PB and Mueller, OM and Mogro-Campero, A and Turner, LG and Johnson, GA},
   Title = {A high-temperature superconducting receiver for nuclear
             magnetic resonance microscopy.},
   Journal = {Science},
   Volume = {259},
   Number = {5096},
   Pages = {793-795},
   Year = {1993},
   Month = {February},
   ISSN = {0036-8075},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8430331},
   Abstract = {A high-temperature superconducting-receiver system for use
             in nuclear magnetic resonance (NMR) microscopy is described.
             The scaling behavior of sources of sample and receiver-coil
             noise is analyzed, and it is demonstrated that Johnson, or
             thermal, noise in the receiver coil is the factor that
             limits resolution. The behavior of superconductors in the
             environment of an NMR experiment is examined, and a
             prototypical system for imaging biological specimens is
             discussed. Preliminary spin-echo images are shown, and the
             ultimate limits of the signal-to-noise ratio of the probe
             are investigated.},
   Key = {Black93}
}

@booklet{Schostarez93,
   Author = {H. J. Schostarez and J. M. Fisher and A. R. Diani and M. J.
             Mulholland and K. L. Schull and M. J. Zaya and T. J. Vidmar and G. A. Johnson and M. F. Kubicek and S. J. Humphrey and M. P. Smith},
   Title = {Synthesis and hair-growth stimulatory activity of
             5-fluoro-6-(1-piperidinyl)-2,4-pyrimidinediamine, 3-oxide
             (u-83,868)},
   Journal = {Abstracts Of Papers Of The American Chemical
             Society},
   Volume = {205},
   Pages = {131 -- MEDI},
   Year = {1993},
   Month = {March},
   Key = {Schostarez93}
}

@booklet{Johnson93b,
   Author = {G. A. Johnson and J. T. Handa and C. A. Baker and G. J.
             Jaffe},
   Title = {Minoxidil inhibits human rpe cell-growth by a mechanism
             dependent on the conversion to minoxidil
             sulfate},
   Journal = {Investigative Ophthalmology \& Visual Science},
   Volume = {34},
   Number = {4},
   Pages = {1426 -- 1426},
   Year = {1993},
   Month = {March},
   Key = {Johnson93b}
}

@booklet{Johnson93,
   Author = {Johnson, GA and Benveniste, H and Black, RD and Hedlund, LW and Maronpot, RR and Smith, BR},
   Title = {Histology by magnetic resonance microscopy.},
   Journal = {Magnetic resonance quarterly},
   Volume = {9},
   Number = {1},
   Pages = {1-30},
   Year = {1993},
   Month = {March},
   ISSN = {0899-9422},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8512830},
   Abstract = {Magnetic resonance microscopy (MRM) has advanced from a
             technical challenge to a practical tool in a wide range of
             basic sciences. This article focuses on the use of MRM as a
             tool for histological studies. The technical challenges of
             limited signal to noise have been overcome by improved
             radio-frequency (rf) coil design and 3DFT encoding with
             large arrays. Resolution limits imposed by motion in in vivo
             studies have been overcome by improved physiologic
             monitoring and control and projection encoding. Integration
             of technologies now permits routine studies in vivo down to
             50 microns. MRM has also been applied to in vitro studies of
             fixed tissues where absence of motion allows studies down to
             10 microns. The nondestructive nature of the technique
             allows repeated studies of the same sample, retrospective
             studies through any arbitrary plane, registered studies
             using different contrast mechanisms, and examination of
             valuable specimens. The many and unique proton contrasts
             provided by MRM, i.e., T1, T2, and diffusion weighting,
             permit direct examination of the state of water in tissues,
             something not possible with other microscopic techniques.
             Finally, the inherent three-dimensional nature of MRM allows
             acquisition of perfectly registered isotropic 3D arrays
             that, when displayed with appropriate visualization tools,
             provide new perspectives to histologic examination. The
             technology of MRM continues to develop rapidly. New pulse
             sequences are reducing acquisition times. New computer
             architectures allow larger arrays. A new class of
             superconducting rf probe has increased the signal to noise
             ratio by 10 times. These developments promise routine use of
             MRM in histology studies with resolution to 1 micron in the
             near future.},
   Key = {Johnson93}
}

@article{fds132878,
   Author = {GA Johnson and H Benveniste and RD Black and LW Hedlund and RR Maronpot and BR Smith},
   Title = {Histology by magnetic resonance microscopy.},
   Journal = {Magnetic resonance quarterly, UNITED STATES},
   Volume = {9},
   Number = {1},
   Pages = {1-30},
   Year = {1993},
   Month = {March},
   ISSN = {0899-9422},
   Keywords = {Animals • Histological Techniques • Histology*
             • Image Enhancement • Magnetic Resonance Imaging
             • Microscopy • Tissue Fixation •
             instrumentation • methods*},
   Abstract = {Magnetic resonance microscopy (MRM) has advanced from a
             technical challenge to a practical tool in a wide range of
             basic sciences. This article focuses on the use of MRM as a
             tool for histological studies. The technical challenges of
             limited signal to noise have been overcome by improved
             radio-frequency (rf) coil design and 3DFT encoding with
             large arrays. Resolution limits imposed by motion in in vivo
             studies have been overcome by improved physiologic
             monitoring and control and projection encoding. Integration
             of technologies now permits routine studies in vivo down to
             50 microns. MRM has also been applied to in vitro studies of
             fixed tissues where absence of motion allows studies down to
             10 microns. The nondestructive nature of the technique
             allows repeated studies of the same sample, retrospective
             studies through any arbitrary plane, registered studies
             using different contrast mechanisms, and examination of
             valuable specimens. The many and unique proton contrasts
             provided by MRM, i.e., T1, T2, and diffusion weighting,
             permit direct examination of the state of water in tissues,
             something not possible with other microscopic techniques.
             Finally, the inherent three-dimensional nature of MRM allows
             acquisition of perfectly registered isotropic 3D arrays
             that, when displayed with appropriate visualization tools,
             provide new perspectives to histologic examination. The
             technology of MRM continues to develop rapidly. New pulse
             sequences are reducing acquisition times. New computer
             architectures allow larger arrays. A new class of
             superconducting rf probe has increased the signal to noise
             ratio by 10 times. These developments promise routine use of
             MRM in histology studies with resolution to 1 micron in the
             near future.},
   Key = {fds132878}
}

@booklet{Park93,
   Author = {M. K. Park and D. H. Lee and G. A. Johnson},
   Title = {Oscillometric blood pressures in the arm, thigh, and calf in
             healthy-children and those with aortic coarctation},
   Journal = {Pediatrics},
   Volume = {91},
   Number = {4},
   Pages = {761 -- 765},
   Year = {1993},
   Month = {April},
   Key = {Park93}
}

@booklet{Walker93a,
   Author = {L. C. Walker and S. Murad and A. G. Messenger and G. A.
             Johnson and S. R. Pinnell},
   Title = {Connective-tissue effects of minoxidil and its hydroxy
             derivatives on human dermal papilla cells in
             culture},
   Journal = {Clinical Research},
   Volume = {41},
   Number = {2},
   Pages = {A437 -- A437},
   Year = {1993},
   Month = {April},
   Key = {Walker93a}
}

@booklet{Walker93,
   Author = {L. C. Walker and S. Murad and A. G. Messenger and G. A.
             Johnson and S. R. Pinnell},
   Title = {Connective-tissue effects of minoxidil and its hydroxy
             derivatives on human dermal papilla cells in
             culture},
   Journal = {Journal Of Investigative Dermatology},
   Volume = {100},
   Number = {4},
   Pages = {552 -- 552},
   Year = {1993},
   Month = {April},
   Key = {Walker93}
}

@booklet{Veres93,
   Author = {VERES, JS and COFER, GP and JOHNSON, GA},
   Title = {MAGNETIC-RESONANCE-IMAGING OF LEAVES},
   Journal = {New Phytologist},
   Volume = {123},
   Number = {4},
   Pages = {769-774},
   Year = {1993},
   Month = {April},
   ISSN = {0028-646X},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993LE53500015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1111/j.1469-8137.1993.tb03788.x},
   Key = {Veres93}
}

@article{fds174280,
   Author = {MK Park and DH Lee and GA Johnson},
   Title = {Oscillometric blood pressures in the arm, thigh, and calf in
             healthy children and those with aortic coarctation.},
   Journal = {Pediatrics},
   Volume = {91},
   Number = {4},
   Pages = {761-5},
   Year = {1993},
   Month = {April},
   ISSN = {0031-4005},
   Keywords = {Adolescent • Aortic Coarctation • Arm •
             Arteries • Blood Pressure Determination • Blood
             Pressure* • Case-Control Studies • Child •
             Child, Preschool • Female • Humans • Leg
             • Male • Oscillometry • Reference Values
             • Thigh • blood supply • diagnosis •
             methods • physiology • physiopathology*},
   Abstract = {Comparing blood pressure (BP) obtained in the arm with that
             obtained in the thigh or calf is important in the diagnosis
             of aortic coarctation. However, normative mean and range of
             differences in BP between the arm and lower extremity sites
             are not available for normal children. It is also not known
             how accurately the differences in BP between the arm and the
             lower extremity sites predict the pulsed Doppler estimation
             of systolic pressure (SP) gradient across an aortic
             coarctation. To resolve these questions, the authors
             obtained two BP measurements by an oscillometric (Dinamap)
             method in the arm, thigh, and calf in 74 healthy children
             aged 4 to 16 years. Oscillometric BP was also obtained in 21
             children aged 3 to 17 years with preoperative or
             postoperative aortic coarctation and BP gradients were
             compared with that estimated by the pulsed Doppler method.
             Overall, SP was higher in the thigh and calf than in the
             arm. The gradients in SP expressed as arm SP minus calf SP
             [S(A-C)] and arm SP minus thigh SP [S(A-T)] were
             significantly greater in children 4 through 8 years old than
             in those 9 to 16 years old. The S(A-C) was -9.3 (+/- 7.4 SD)
             mm Hg in the 4- through 8-year group and -5.0 (+/- 6.9 SD)
             mm Hg in the 9- to 16-year group. The S(A-T) was -7.1 (+/-
             6.8 SD) mm Hg in the 4- through 8-year group and -2.4 (+/-
             7.7 SD) mm Hg in the 9- to 16-year group.(ABSTRACT TRUNCATED
             AT 250 WORDS)},
   Language = {eng},
   Key = {fds174280}
}

@booklet{Waldon93,
   Author = {D. J. Waldon and T. T. Kawabe and C. A. Baker and G. A.
             Johnson and A. E. Buhl},
   Title = {Enhanced in-vitro hair-growth at the air-liquid interface -
             minoxidil preserves the root sheath in cultured whisker
             follicles},
   Journal = {In Vitro Cellular \& Developmental Biology-animal},
   Volume = {29A},
   Number = {7},
   Pages = {555 -- 561},
   Year = {1993},
   Month = {July},
   Key = {Waldon93}
}

@booklet{Zhou93a,
   Author = {Zhou, X and Cofer, GP and Suddarth, SA and Johnson,
             GA},
   Title = {High-field MR microscopy using fast spin-echoes.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {30},
   Number = {1},
   Pages = {60-67},
   Year = {1993},
   Month = {July},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8371676},
   Abstract = {Fast spin-echo imaging has been investigated with attention
             to the requirements and opportunities for high-field MR
             microscopy. Two- and three-dimensional versions were
             implemented at 2.0 T, 7.1 T, and 9.4 T. At these fields, at
             least eight echoes were collectable with a 10 ms TE from
             fixed tissue specimens and living animals, giving an
             eightfold improvement in imaging efficiency. To reduce the
             phase-encoding gradient amplitude and its duty cycle, a
             modified pulse sequence with phase accumulation was
             developed. Images obtained using this pulse sequence
             exhibited comparable signal-to-noise (SNR) to those obtained
             from the conventional fast spin-echo pulse sequences. Signal
             losses due to imperfections in RF pulses and lack of phase
             rewinders were offset in this sequence by reduced diffusion
             losses incurred with the gradients required for MR
             microscopy. Image SNR, contrast, edge effects and spatial
             resolution for three k-space sampling schemes were studied
             experimentally and theoretically. One method of sampling
             k-space, 4-GROUP FSE, was found particularly useful in
             producing varied T2 contrast at high field. Two-dimensional
             images of tissue specimens were obtained in a total
             acquisition time of 1 to 2 min with in-plane resolution
             between 30 to 70 microns, and 3D images with 256(3) arrays
             were acquired from fixed rat brain tissue (isotropic voxel =
             70 microns) and a living rat (isotropic voxel = 117 microns)
             in approximately 4.5 h.},
   Key = {Zhou93a}
}

@article{fds132762,
   Author = {X Zhou and GP Cofer and SA Suddarth and GA Johnson},
   Title = {High-field MR microscopy using fast spin-echoes.},
   Journal = {Magnetic resonance in medicine : official journal of the
             Society of Magnetic Resonance in Medicine / Society of
             Magnetic Resonance in Medicine, UNITED STATES},
   Volume = {30},
   Number = {1},
   Pages = {60-7},
   Year = {1993},
   Month = {July},
   ISSN = {0740-3194},
   Keywords = {Animals • Brain • Brain Neoplasms • Cerebral
             Cortex • Corpus Callosum • Humans • Image
             Enhancement • Image Processing, Computer-Assisted
             • Magnetic Resonance Imaging* • Melanoma •
             Microscopy* • Models, Structural • Rats •
             anatomy & histology • methods •
             pathology},
   Abstract = {Fast spin-echo imaging has been investigated with attention
             to the requirements and opportunities for high-field MR
             microscopy. Two- and three-dimensional versions were
             implemented at 2.0 T, 7.1 T, and 9.4 T. At these fields, at
             least eight echoes were collectable with a 10 ms TE from
             fixed tissue specimens and living animals, giving an
             eightfold improvement in imaging efficiency. To reduce the
             phase-encoding gradient amplitude and its duty cycle, a
             modified pulse sequence with phase accumulation was
             developed. Images obtained using this pulse sequence
             exhibited comparable signal-to-noise (SNR) to those obtained
             from the conventional fast spin-echo pulse sequences. Signal
             losses due to imperfections in RF pulses and lack of phase
             rewinders were offset in this sequence by reduced diffusion
             losses incurred with the gradients required for MR
             microscopy. Image SNR, contrast, edge effects and spatial
             resolution for three k-space sampling schemes were studied
             experimentally and theoretically. One method of sampling
             k-space, 4-GROUP FSE, was found particularly useful in
             producing varied T2 contrast at high field. Two-dimensional
             images of tissue specimens were obtained in a total
             acquisition time of 1 to 2 min with in-plane resolution
             between 30 to 70 microns, and 3D images with 256(3) arrays
             were acquired from fixed rat brain tissue (isotropic voxel =
             70 microns) and a living rat (isotropic voxel = 117 microns)
             in approximately 4.5 h.},
   Key = {fds132762}
}

@article{fds174128,
   Author = {DJ Waldon and TT Kawabe and CA Baker and GA Johnson and AE
             Buhl},
   Title = {Enhanced in vitro hair growth at the air-liquid interface:
             minoxidil preserves the root sheath in cultured whisker
             follicles.},
   Journal = {In vitro cellular & developmental biology.
             Animal},
   Volume = {29A},
   Number = {7},
   Pages = {555-61},
   Year = {1993},
   Month = {July},
   ISSN = {1071-2690},
   Keywords = {Air • Animals • Cells, Cultured •
             Collagenases • Cysteine • Gelatin Sponge,
             Absorbable • Glycoproteins • Guanidines •
             Hair • Keratins • Mice • Minoxidil •
             Pyridines • Sulfotransferases • Tissue Inhibitor
             of Metalloproteinases • Vibrissae • analysis
             • antagonists & inhibitors • chemistry •
             cytology* • growth & development* • metabolism
             • pharmacology • pharmacology*},
   Abstract = {Inasmuch as hair follicles are difficult to maintain in
             culture, the study of hair biology using cultured hair
             follicles has met with only limited success. In our attempts
             to solve the problem of follicle degeneration, we cultured
             follicles at the air-surface interface on a modified
             collagen matrix (Gelfoam). In follicles cultured at the
             air-surface or submerged, we examined follicular morphology,
             hair shaft growth, sulfotransferase levels, cysteine
             incorporation, an expression of a tissue inhibitor of
             metalloproteinase (TIMP), and ultra-high sulfur keratin
             (UHSK). Follicles cultured at the air-liquid interface
             produced a 2.7-fold increase in hair growth and maintained
             an anagen-like morphology. Substrates such as nylon mesh
             seeded with fibroblasts, Full Thickness Skin, or 5-microns
             polycarbonate filter also supported hair growth, whereas
             Gelfilm, GF-A glass filter, filter paper, or 1-micron
             polycarbonate filter did not. The UHSK expression was
             significantly higher in the air-liquid interface cultures
             compared to the submerged culture. Several potassium channel
             openers, including minoxidil, a minoxidil analog, and the
             pinacidil analog (P-1075), all stimulated significant
             cysteine incorporation in follicles. Minoxidil and its
             analog specifically preserved the follicular root sheath, in
             contrast to P-1075 which did not, indicating a difference in
             the two drug types. The preservation of the root sheath was
             measured by increased TIMP expression and sulfotransferase
             activity and indicates that the root sheath is a target
             tissue for minoxidil. Our results show that follicles
             cultured at the air-liquid interface maintain a better
             morphology and produced greater hair growth than follicles
             cultured on tissue culture plastic.},
   Language = {eng},
   Key = {fds174128}
}

@booklet{Beaulieu93,
   Author = {Beaulieu, CF and Zhou, X and Cofer, GP and Johnson,
             GA},
   Title = {Diffusion-weighted MR microscopy with fast
             spin-echo.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {30},
   Number = {2},
   Pages = {201-206},
   Year = {1993},
   Month = {August},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8366801},
   Abstract = {A diffusion-weighted fast spin-echo (FSE) imaging sequence
             for high-field MR microscopy was developed and
             experimentally validated in a phantom and in a live rat.
             Pulsed diffusion gradients were executed before and after
             the initial 180 degrees pulse in the FSE pulse train. This
             produced diffusion-related reductions in image signal
             intensity corresponding to gradient ("b") factors between
             1.80 and 1352 s/mm2. The degree of diffusion weighting was
             demonstrated to be independent of echo train length for
             experiments using trains up to 16 echoes long. Quantitative
             measurements on a phantom and on a live rat produced
             diffusion coefficients consistent with literature values.
             Importantly, the eight- to 16-fold increase in imaging
             efficiency with FSE was not accompanied by a significant
             loss of spatial resolution or contrast. This permits
             acquisition of in vivo three-dimensional data in time
             periods that are appropriate for evolving biological
             processes. The combination of accurate diffusion weighting
             and high spatial resolution provided by FSE makes the
             technique particularly useful for MR microscopy.},
   Key = {Beaulieu93}
}

@article{fds132826,
   Author = {CF Beaulieu and X Zhou and GP Cofer and GA Johnson},
   Title = {Diffusion-weighted MR microscopy with fast
             spin-echo.},
   Journal = {Magnetic resonance in medicine : official journal of the
             Society of Magnetic Resonance in Medicine / Society of
             Magnetic Resonance in Medicine, UNITED STATES},
   Volume = {30},
   Number = {2},
   Pages = {201-6},
   Year = {1993},
   Month = {August},
   ISSN = {0740-3194},
   Keywords = {Animals • Diffusion • Image Processing,
             Computer-Assisted • Magnetic Resonance Imaging •
             Microscopy • Models, Structural • Rats •
             methods*},
   Abstract = {A diffusion-weighted fast spin-echo (FSE) imaging sequence
             for high-field MR microscopy was developed and
             experimentally validated in a phantom and in a live rat.
             Pulsed diffusion gradients were executed before and after
             the initial 180 degrees pulse in the FSE pulse train. This
             produced diffusion-related reductions in image signal
             intensity corresponding to gradient ("b") factors between
             1.80 and 1352 s/mm2. The degree of diffusion weighting was
             demonstrated to be independent of echo train length for
             experiments using trains up to 16 echoes long. Quantitative
             measurements on a phantom and on a live rat produced
             diffusion coefficients consistent with literature values.
             Importantly, the eight- to 16-fold increase in imaging
             efficiency with FSE was not accompanied by a significant
             loss of spatial resolution or contrast. This permits
             acquisition of in vivo three-dimensional data in time
             periods that are appropriate for evolving biological
             processes. The combination of accurate diffusion weighting
             and high spatial resolution provided by FSE makes the
             technique particularly useful for MR microscopy.},
   Key = {fds132826}
}

@booklet{Zhou93,
   Author = {Zhou, X and Liang, ZP and Cofer, GP and Beaulieu, CF and Suddarth, SA and Johnson, GA},
   Title = {Reduction of ringing and blurring artifacts in fast
             spin-echo imaging.},
   Journal = {Journal of Magnetic Resonance Imaging},
   Volume = {3},
   Number = {5},
   Pages = {803-807},
   Year = {1993},
   Month = {September},
   ISSN = {1053-1807},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8400569},
   Abstract = {A simple method was devised to reduce ringing and blurring
             artifacts caused by discontinuous T2 weighting of k-space
             data in fast spin-echo magnetic resonance (MR) imaging. The
             method demodulates the weighting function along the
             phase-encoding direction by using multiple T2 values derived
             from a set of non-phase-encoded echoes obtained from an
             extra excitation. The performance of this method was
             evaluated by computer simulations and experiments, which
             confirmed its capability of effectively reducing or, in some
             cases, even completely removing the ringing and blurring
             artifacts. The results also show that the proposed method
             produces better results than other artifact reduction
             methods. The method is particularly useful at high magnetic
             field strengths (7.1-9.4 T) and with strong gradients (> 20
             G/cm) used in MR microscopy, in which the apparent T2 values
             are short for most tissues. The authors expect that the
             proposed method will find useful applications in various
             fast spin-echo pulse sequences.},
   Key = {Zhou93}
}

@booklet{Woo93,
   Author = {S. L. Y. Woo and G. A. Johnson and B. A.
             Smith},
   Title = {Mathematical-modeling of ligaments and tendons},
   Journal = {Journal Of Biomechanical Engineering-transactions Of The
             Asme},
   Volume = {115},
   Number = {4},
   Pages = {468 -- 473},
   Year = {1993},
   Month = {November},
   Key = {Woo93}
}

@article{fds174131,
   Author = {SL Woo and GA Johnson and BA Smith},
   Title = {Mathematical modeling of ligaments and tendons.},
   Journal = {Journal of biomechanical engineering},
   Volume = {115},
   Number = {4B},
   Pages = {468-73},
   Year = {1993},
   Month = {November},
   ISSN = {0148-0731},
   Keywords = {Animals • Biomechanics • Elasticity •
             Ligaments • Models, Biological* • Models,
             Structural • Reference Values • Stress,
             Physiological • Tendons • Viscosity •
             physiology* • physiopathology},
   Abstract = {Ligaments and tendons serve a variety of important functions
             in maintaining the structure of the human body. Although
             abundant literature exists describing experimental
             investigations of these tissues, mathematical modeling of
             ligaments and tendons also contributes significantly to
             understanding their behavior. This paper presents a survey
             of developments in mathematical modeling of ligaments and
             tendons over the past 20 years. Mathematical descriptions of
             ligaments and tendons are identified as either elastic or
             viscoelastic, and are discussed in chronological order.
             Elastic models assume that ligaments and tendons do not
             display time dependent behavior and thus, they focus on
             describing the nonlinear aspects of their mechanical
             response. On the other hand, viscoelastic models incorporate
             time dependent effects into their mathematical description.
             In particular, two viscoelastic models are discussed in
             detail; quasi-linear viscoelasticity (QLV), which has been
             widely used in the past 20 years, and the recently proposed
             single integral finite strain (SIFS) model.},
   Language = {eng},
   Key = {fds174131}
}

@booklet{Baker94,
   Author = {C. A. Baker and H. Uno and G. A. Johnson},
   Title = {Minoxidil sulfation in the hair follicle},
   Journal = {Skin Pharmacology},
   Volume = {7},
   Number = {6},
   Pages = {335 -- 339},
   Year = {1994},
   Key = {Baker94}
}

@booklet{Nielsen94,
   Author = {C. H. Nielsen and G. A. Johnson},
   Title = {The experience of complete neuromuscular blockade in awake
             patients},
   Journal = {Journal Of Clinical Anesthesia},
   Volume = {6},
   Number = {5},
   Pages = {450 -- 450},
   Year = {1994},
   Key = {Nielsen94}
}

@article{fds174125,
   Author = {CA Baker and H Uno and GA Johnson},
   Title = {Minoxidil sulfation in the hair follicle.},
   Journal = {Skin pharmacology : the official journal of the Skin
             Pharmacology Society},
   Volume = {7},
   Number = {6},
   Pages = {335-9},
   Year = {1994},
   ISSN = {1011-0283},
   Keywords = {Animals • Female • Hair • Macaca •
             Minoxidil • Sulfates • Sulfotransferases •
             metabolism • metabolism*},
   Abstract = {The in vivo model which may be the most accurate for the
             ability to predict hair growth in humans, and which was
             utilized in the preclinical development of minoxidil, is the
             adult stumptailed macaque. Previous reports have suggested
             that the enzyme activity which accounts for the activation
             of minoxidil, i.e., minoxidil sulfotransferase, is present
             in skin. We have demonstrated that scalp skin from the
             stumptailed macaque contains minoxidil sulfotransferase
             activity, and further with dissection of that scalp skin
             into epidermis, dermis and hair follicle, most of
             sulfotransferase activity was present in the follicle.
             Sulfotransferase activity in the hair follicle in
             freeze-dried scalp skin sections from 9 stumptailed macaques
             ranged from 47 to 84% of the total (mean 61 +/- 12%). Much
             less minoxidil sulfotransferase activity was measured in the
             epidermis (mean 18 +/- 11%, with a range of 2-37%) and the
             dermis (mean 21 +/- 8%, with a range of 4-35%) of these
             scalp sections. These results indicate that the scalp skin
             from the stumptailed macaque contains minoxidil
             sulfotransferase activity and this activity is largely
             localized in the hair follicle which may account for its
             ability to stimulate hair growth in this animal
             model.},
   Language = {eng},
   Key = {fds174125}
}

@booklet{Macfall94,
   Author = {MacFall, JS and Johnson, GA},
   Title = {The architecture of plant vasculature and transport as seen
             with magnetic resonance microscopy},
   Journal = {Canadian Journal of Botany},
   Volume = {72},
   Number = {11},
   Pages = {1561-1573},
   Year = {1994},
   Key = {Macfall94}
}

@article{fds268745,
   Author = {MACFALL, JS and JOHNSON, GA},
   Title = {NONDESTRUCTIVE, 3-DIMENSIONAL STUDY OF ROOT-GROWTH WITH
             MAGNETIC-RESONANCE MICROSCOPY (MRM)},
   Journal = {RESEARCH AND APPLICATIONS OF CHEMICAL SCIENCES IN
             FORESTRY},
   Volume = {104},
   Pages = {18-18},
   Year = {1994},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994BA75T00005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {fds268745}
}

@article{fds268748,
   Author = {MACFALL, JS and SPAINE, PC and DOUDRICK, RE and JOHNSON,
             GA},
   Title = {MAGNETIC-RESONANCE MICROSCOPY (MRM) OF WATER TRANSPORT AND
             BINDING IN FUSIFORM RUST GALLS},
   Journal = {RESEARCH AND APPLICATIONS OF CHEMICAL SCIENCES IN
             FORESTRY},
   Volume = {104},
   Pages = {17-17},
   Year = {1994},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994BA75T00004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {fds268748}
}

@article{fds268749,
   Author = {MACFALL, JS and JOHNSON, GA},
   Title = {USE OF MAGNETIC-RESONANCE-IMAGING IN THE STUDY OF PLANTS AND
             SOILS},
   Journal = {SSSA special publication series},
   Number = {36},
   Pages = {99-113},
   Year = {1994},
   ISBN = {0-89118-808-8},
   ISSN = {0081-1904},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994BB18K00009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {fds268749}
}

@article{fds325757,
   Author = {SPAINE, P and MACFALL, JS and JOHNSON, GA},
   Title = {MAGNETIC-RESONANCE MICROSCOPY OF WATER-MOVEMENT THROUGH
             FUSIFORM RUST GALLS OF PINE},
   Journal = {RESEARCH AND APPLICATIONS OF CHEMICAL SCIENCES IN
             FORESTRY},
   Volume = {104},
   Pages = {11-16},
   Year = {1994},
   Key = {fds325757}
}

@article{fds132714,
   Title = {3. J.C.M. Hsu, G.A. Johnson, W.M. Smith K.A. Reimer, R.E.
             Ideker. Magnetic Resonance Imaging of Chronic Myocardial
             Infarcts in Formalin Fixed Human Autopsy Specimens.
             Circulation 89:2133-2140 (1993).},
   Year = {1994},
   Key = {fds132714}
}

@article{fds132715,
   Title = {6. M.M. Henson, O.W. Henson, S.L. Gewalt, J.L. Wilson, G. A.
             Johnson. Imaging the Cochlea by MRM. Hearing Research
             75:75-80 (1994).},
   Year = {1994},
   Key = {fds132715}
}

@article{fds132716,
   Title = {1. Cho ZH, Ro YM. Multipoint K-Space Mapping Technique.
             Reviewed for Magn Reson. in Med.},
   Year = {1994},
   Key = {fds132716}
}

@article{fds132717,
   Title = {2. Hafner S, Kuhn W. NMR Imaging of Water Contentin Chips.
             Reviewed for Magn. Reson. Imaging.},
   Year = {1994},
   Key = {fds132717}
}

@article{fds132726,
   Title = {1. C.F. Beaulieu, X. Zhou, G.P. Cofer, G.A. Johnson.
             Diffusion-Weighted MR Microscopy with Fast Spin-Echo.
             Magnetic Resonance in Medicine 30, 201-206
             (1993).},
   Year = {1994},
   Key = {fds132726}
}

@article{fds132727,
   Title = {2. H. Benveniste, G. Johnson, in "Microcirculatory Stasis in
             the Brain" (M. Tomita, Mchedlishvili, W. Roseblum, W.D.
             Heiss, Y. Fukuuchi, Ed.), p. 369-376, Excerpta Medica,
             Amsterdam, 1993.},
   Year = {1994},
   Key = {fds132727}
}

@article{fds132728,
   Title = {4. X. Zhou, G.P. Cofer S. A. Suddarth, G. A. Johnson. High
             Field MR Microscopy Using Fast Spin Echoes. Magn Reson Med
             30:60-67 (1993).},
   Year = {1994},
   Key = {fds132728}
}

@article{fds132729,
   Title = {5. X. Zhou, Z. P. Liang, G.P. Cofer, C.F. Beaulieu, S.A.
             Suddarth, G.A. Johnson. Reduction of Ringing and Blurring
             Artifacts in Fast Spin-Echo Images. J Magn Reson Imag
             3:803-807 (1993).},
   Year = {1994},
   Key = {fds132729}
}

@article{fds132730,
   Title = {7. J. MacFall, P. Spaine, R. Doudrick, G. Johnson.
             Alterations in Growth and Water Transport Processes in
             Fusiform Rust Galls of Pine as Determined by Magnetic
             Resonance Microsopy. Phytopathology 84:288-293
             (1994).},
   Year = {1994},
   Key = {fds132730}
}

@article{fds132731,
   Title = {8. B.R. Smith, G.A. Johnson, E.V. Groman, E.A. Linney.
             Magnetic Resonance Microscopy of Mouse Embryos. Proc. Nat.
             Acad. Sci. USA 91:3530-3533 (1994).},
   Year = {1994},
   Key = {fds132731}
}

@booklet{Gunderson94,
   Author = {R. O. Gunderson and M. Oprisan and G. A. Johnson and E. C.
             Pfeiffer and D. L. Smith and A. W. Schneider and H. Volpe and B. Silverstein and R. J. Ringlee and T. E. Mcdermott and V. S. Rashkes and R. B. Adler and C. R. Heising and T. S.
             White and M. G. Lau},
   Title = {Transformer magnetizing current and iron-core losses in
             harmonic power-flow - discussion},
   Journal = {Ieee Transactions On Power Delivery},
   Volume = {9},
   Number = {1},
   Pages = {34 -- 39},
   Year = {1994},
   Month = {January},
   Key = {Gunderson94}
}

@booklet{Macfall94a,
   Author = {J. S. Macfall and P. Spaine and R. Doudrick and G. A.
             Johnson},
   Title = {Alterations in growth and water-transport processes in
             fusiform rust galls of pine, determined by
             magnetic-resonance microscopy},
   Journal = {Phytopathology},
   Volume = {84},
   Number = {3},
   Pages = {288 -- 293},
   Year = {1994},
   Month = {March},
   Key = {Macfall94a}
}

@booklet{Boyko94,
   Author = {Boyko, OB and Alston, SR and Fuller, GN and Hulette, CM and Johnson, GA and Burger, PC},
   Title = {Utility of postmortem magnetic resonance imaging in clinical
             neuropathology.},
   Journal = {Archives of Pathology and Laboratory Medicine},
   Volume = {118},
   Number = {3},
   Pages = {219-225},
   Year = {1994},
   Month = {March},
   ISSN = {0003-9985},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8135623},
   Abstract = {Over 200 brains were examined by postmortem magnetic
             resonance imaging to determine the utility of this imaging
             procedure as an adjunct to the standard postmortem
             examination of the brain and spinal cord. One unembalmed
             cadaver was also studied using a conventional 1.5-tesla (T)
             field-strength unit, and three formalin-fixed sections of
             the hippocampus were imaged using a high field-strength
             (7.0-T) prototype imaging system. The postmortem magnetic
             resonance images proved to be an invaluable aid that
             complemented the standard pathologic examination of the
             brain and spinal cord. The compelling advantages of this
             postmortem radiographic procedure included the
             three-dimensional aspects of the images; the ability to
             detect mineral (ie, iron) deposits; small focal lesions such
             as hemorrhages or infarcts; and the ability to evaluate the
             extent of cerebral edema. For the same reasons, as well as
             its archival potential for documenting the topographic
             distribution of pathologic processes, this technique has
             great promise for forensic cases. High field-strength
             (7.0-T) imaging brought the resolution of magnetic resonance
             to the microscopic level and reaffirmed the potential value
             of magnetic resonance imaging for diagnostic and
             investigative studies in which both the histologic and fine
             radiologic features of lesions are of interest.},
   Key = {Boyko94}
}

@article{fds157077,
   Author = {OB Boyko, SR Alston and GN Fuller and CM Hulette and GA Johnson and PC
             Burger},
   Title = {Utility of postmortem magnetic resonance imaging in clinical
             neuropathology.},
   Journal = {Archives of pathology & laboratory medicine, UNITED
             STATES},
   Volume = {118},
   Number = {3},
   Pages = {219-25},
   Year = {1994},
   Month = {March},
   ISSN = {0003-9985},
   Keywords = {Autopsy • Brain • Central Nervous System •
             Central Nervous System Neoplasms • Cerebrovascular
             Disorders • Humans • Magnetic Resonance Imaging*
             • Multiple Sclerosis • Nervous System Diseases
             • injuries • methods* • pathology •
             pathology*},
   Abstract = {Over 200 brains were examined by postmortem magnetic
             resonance imaging to determine the utility of this imaging
             procedure as an adjunct to the standard postmortem
             examination of the brain and spinal cord. One unembalmed
             cadaver was also studied using a conventional 1.5-tesla (T)
             field-strength unit, and three formalin-fixed sections of
             the hippocampus were imaged using a high field-strength
             (7.0-T) prototype imaging system. The postmortem magnetic
             resonance images proved to be an invaluable aid that
             complemented the standard pathologic examination of the
             brain and spinal cord. The compelling advantages of this
             postmortem radiographic procedure included the
             three-dimensional aspects of the images; the ability to
             detect mineral (ie, iron) deposits; small focal lesions such
             as hemorrhages or infarcts; and the ability to evaluate the
             extent of cerebral edema. For the same reasons, as well as
             its archival potential for documenting the topographic
             distribution of pathologic processes, this technique has
             great promise for forensic cases. High field-strength
             (7.0-T) imaging brought the resolution of magnetic resonance
             to the microscopic level and reaffirmed the potential value
             of magnetic resonance imaging for diagnostic and
             investigative studies in which both the histologic and fine
             radiologic features of lesions are of interest.},
   Key = {fds157077}
}

@booklet{Buhl94,
   Author = {A. E. Buhl and C. A. Baker and A. J. Dietz and F. T. Murray and G. A. Johnson},
   Title = {Minoxidil sulfotransferase activity influences the efficacy
             of rogaine(r) topical solutions (ts) - enzyme studies using
             scalp and platelets},
   Journal = {Journal Of Investigative Dermatology},
   Volume = {102},
   Number = {4},
   Pages = {534 -- 534},
   Year = {1994},
   Month = {April},
   Key = {Buhl94}
}

@article{fds132863,
   Author = {BR Smith and GA Johnson and EV Groman and E Linney},
   Title = {Magnetic resonance microscopy of mouse embryos.},
   Journal = {Proceedings of the National Academy of Sciences of the
             United States of America, UNITED STATES},
   Volume = {91},
   Number = {9},
   Pages = {3530-3},
   Year = {1994},
   Month = {April},
   ISSN = {0027-8424},
   Keywords = {Age Factors • Albumins • Animals • Contrast
             Media • Gadolinium DTPA* • Image Processing,
             Computer-Assisted • Mice • Organometallic
             Compounds • Pentetic Acid • analogs & derivatives
             • diagnostic use • embryology*},
   Abstract = {The increased use of the mouse as a model for various
             aspects of mammalian biology has caused a renewed interest
             in developing strategies for examining and comparing normal
             and abnormal mouse embryonic development and anatomy. In
             this study, we have explored the use of magnetic resonance
             microscopy as a tool for these purposes. Techniques for the
             fixation, embedding, perfusion, and image acquisition of
             mouse embryos are described. The perfusion of bovine serum
             albumin-diethylenetriamine pentaacetic anhydride-gadolinium
             as a contrast agent enhances images of the developing
             embryonic vasculature during critical stages of
             organogenesis and allows for comparisons when embryos have
             been treated with teratogens such as retinoic acid. The
             acquired three-dimensional data sets are available for
             archiving, distributing, and postacquisition manipulations
             such as computer segmentation of anatomical
             structures.},
   Key = {fds132863}
}

@booklet{Smith94,
   Author = {Smith, BR and Johnson, GA and Groman, EV and Linney,
             E},
   Title = {Magnetic resonance microscopy of mouse embryos.},
   Journal = {Proceedings of the National Academy of Sciences of
             USA},
   Volume = {91},
   Number = {9},
   Pages = {3530-3533},
   Year = {1994},
   Month = {April},
   ISSN = {0027-8424},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8170941},
   Abstract = {The increased use of the mouse as a model for various
             aspects of mammalian biology has caused a renewed interest
             in developing strategies for examining and comparing normal
             and abnormal mouse embryonic development and anatomy. In
             this study, we have explored the use of magnetic resonance
             microscopy as a tool for these purposes. Techniques for the
             fixation, embedding, perfusion, and image acquisition of
             mouse embryos are described. The perfusion of bovine serum
             albumin-diethylenetriamine pentaacetic anhydride-gadolinium
             as a contrast agent enhances images of the developing
             embryonic vasculature during critical stages of
             organogenesis and allows for comparisons when embryos have
             been treated with teratogens such as retinoic acid. The
             acquired three-dimensional data sets are available for
             archiving, distributing, and postacquisition manipulations
             such as computer segmentation of anatomical
             structures.},
   Key = {Smith94}
}

@booklet{Hsu94,
   Author = {Hsu, JC and Johnson, GA and Smith, WM and Reimer, KA and Ideker,
             RE},
   Title = {Magnetic resonance imaging of chronic myocardial infarcts in
             formalin-fixed human autopsy hearts.},
   Journal = {Circulation},
   Volume = {89},
   Number = {5},
   Pages = {2133-2140},
   Year = {1994},
   Month = {May},
   ISSN = {0009-7322},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8181138},
   Abstract = {BACKGROUND: In post-myocardial infarction patients,
             three-dimensional structure of the infarct as well as
             infarct size are likely to be important factors affecting
             mortality, cardiac function, and arrhythmias. Current
             morphological methods for determining three-dimensional
             infarct structure in autopsied hearts are inexact and time
             consuming. The cardiac magnetic resonance imaging techniques
             used in living patients have shown potential in determining
             infarct size and structure but have limited resolution for
             morphometric postmortem studies. The recent development of
             magnetic resonance microscopy raises the possibility that
             three-dimensional infarct structure can be quantified at
             microscopic levels in autopsied hearts. The purpose of this
             study was to determine the ability of magnetic resonance
             imaging at different spatial resolutions to differentiate
             infarcted from noninfarcted myocardium. METHODS AND RESULTS:
             Magnetic resonance imaging was performed at 2.0 T on cross
             sections taken from 10 autopsied hearts containing old
             myocardial infarcts. T1 was derived from six images with
             repetition times (TRs) for each image ranging from 100 to
             3200 milliseconds. T2 was derived from multi-echo images
             with echo times (TEs) ranging from 10 to 60 milliseconds.
             Resolution was approximately 400 x 400 microns in 2-mm-thick
             slices. Sites of infarcted and noninfarcted tissue were
             identified from histological sections taken from each slice,
             and the T1 and T2 values of these sites were obtained.
             Microscopic images were acquired with voxels of 100 x 100 x
             625 microns, representing tissue volumes more than 1000-fold
             smaller than conventional clinical images. In all cases, T1
             of infarcted tissue (459 +/- 266 milliseconds, mean +/- SD)
             was greater than that of noninfarcted tissue (272 +/- 163
             milliseconds). Also, in all cases, T2 of infarcted tissue
             (49 +/- 14 milliseconds) was greater than that of
             noninfarcted tissue (35 +/- 8 milliseconds). CONCLUSIONS: T1
             and T2 values for infarcted tissue are significantly
             different from those of noninfarcted tissue (P < .001).
             Based on these findings, it should be possible to develop
             techniques to perform three-dimensional imaging and
             quantitation of infarcts with a resolution of 400 microns or
             less. When volumetric three-dimensional imaging was
             performed using a T1-weighted sequence, the resulting 256(3)
             arrays supported isotropic resolution at 400 microns (voxel
             volume, 0.064 mm3). Subsequent volume rendering using a
             compositing algorithm clearly shows the infarcted areas in
             three dimensions. The techniques demonstrate the potential
             for quantitative three-dimensional cardiac morphometry using
             magnetic resonance imaging.},
   Key = {Hsu94}
}

@booklet{Henson94,
   Author = {Henson, MM and Henson, OW and Gewalt, SL and Wilson, JL and Johnson,
             GA},
   Title = {Imaging the cochlea by magnetic resonance
             microscopy.},
   Journal = {Hearing Research},
   Volume = {75},
   Number = {1-2},
   Pages = {75-80},
   Year = {1994},
   Month = {May},
   ISSN = {0378-5955},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8071156},
   Abstract = {The isolated, fixed cochlea of the mustached bat was studied
             with three dimensional magnetic resonance (MR) microscopy.
             The cochlea of this animal is about 4 mm in diameter and its
             entire volume was imaged. With the field of view and matrix
             size used, the volume elements (voxels) making up the volume
             data set were isotropic 25 x 25 x 25 micron cubes. Three
             dimensional (3D) MR microscopy based on isotropic voxels has
             many advantages over commonly used light microscopy: 1) it
             is non destructive; 2) it is much less time consuming; 3) no
             dehydration is required and shrinkage is minimized; 4) the
             data set can be used to create sections in any desired
             plane; 5) the proper alignment of sections is inherent in
             the 3D acquisition so that no reference points are required;
             6) the entire data set can be viewed from any point of view
             in a volume rendered image; 7) the data is digital and
             features can be enhanced by computer image processing; and
             8) the isotropic dimensions of the voxels make the data
             well-suited for structural reconstructions and measurements.
             Good images of the osseous spiral lamina, spiral ligament,
             scala tympani, scala vestibuli, and nerve bundles were
             obtained. The vestibular (Reissner's) membrane was easily
             identified in the mustached bat and it appears to bulge into
             the scala vestibuli. The visibility of this structure
             suggests that MR microscopy would be well-suited for studies
             of endolymphatic hydrops.},
   Key = {Henson94}
}

@article{fds132818,
   Author = {MM Henson and OW Henson and SL Gewalt and JL Wilson and GA
             Johnson},
   Title = {Imaging the cochlea by magnetic resonance
             microscopy.},
   Journal = {Hearing research, NETHERLANDS},
   Volume = {75},
   Number = {1-2},
   Pages = {75-80},
   Year = {1994},
   Month = {May},
   ISSN = {0378-5955},
   Keywords = {Animals • Chiroptera • Cochlea • Magnetic
             Resonance Imaging* • Scala Tympani • Spiral
             Ganglion • Tissue Fixation • Vestibular Nerve
             • Vestibulocochlear Nerve • anatomy & histology
             • anatomy & histology*},
   Abstract = {The isolated, fixed cochlea of the mustached bat was studied
             with three dimensional magnetic resonance (MR) microscopy.
             The cochlea of this animal is about 4 mm in diameter and its
             entire volume was imaged. With the field of view and matrix
             size used, the volume elements (voxels) making up the volume
             data set were isotropic 25 x 25 x 25 micron cubes. Three
             dimensional (3D) MR microscopy based on isotropic voxels has
             many advantages over commonly used light microscopy: 1) it
             is non destructive; 2) it is much less time consuming; 3) no
             dehydration is required and shrinkage is minimized; 4) the
             data set can be used to create sections in any desired
             plane; 5) the proper alignment of sections is inherent in
             the 3D acquisition so that no reference points are required;
             6) the entire data set can be viewed from any point of view
             in a volume rendered image; 7) the data is digital and
             features can be enhanced by computer image processing; and
             8) the isotropic dimensions of the voxels make the data
             well-suited for structural reconstructions and measurements.
             Good images of the osseous spiral lamina, spiral ligament,
             scala tympani, scala vestibuli, and nerve bundles were
             obtained. The vestibular (Reissner's) membrane was easily
             identified in the mustached bat and it appears to bulge into
             the scala vestibuli. The visibility of this structure
             suggests that MR microscopy would be well-suited for studies
             of endolymphatic hydrops.},
   Key = {fds132818}
}

@article{fds132827,
   Author = {JC Hsu and GA Johnson and WM Smith and KA Reimer and RE
             Ideker},
   Title = {Magnetic resonance imaging of chronic myocardial infarcts in
             formalin-fixed human autopsy hearts.},
   Journal = {Circulation, UNITED STATES},
   Volume = {89},
   Number = {5},
   Pages = {2133-40},
   Year = {1994},
   Month = {May},
   ISSN = {0009-7322},
   Keywords = {Algorithms • Formaldehyde • Fourier Analysis
             • Humans • Image Processing, Computer-Assisted
             • Magnetic Resonance Imaging • Magnetic Resonance
             Spectroscopy • Myocardial Infarction • Myocardium
             • Signal Processing, Computer-Assisted • Tissue
             Fixation • methods • methods* •
             pathology*},
   Abstract = {BACKGROUND: In post-myocardial infarction patients,
             three-dimensional structure of the infarct as well as
             infarct size are likely to be important factors affecting
             mortality, cardiac function, and arrhythmias. Current
             morphological methods for determining three-dimensional
             infarct structure in autopsied hearts are inexact and time
             consuming. The cardiac magnetic resonance imaging techniques
             used in living patients have shown potential in determining
             infarct size and structure but have limited resolution for
             morphometric postmortem studies. The recent development of
             magnetic resonance microscopy raises the possibility that
             three-dimensional infarct structure can be quantified at
             microscopic levels in autopsied hearts. The purpose of this
             study was to determine the ability of magnetic resonance
             imaging at different spatial resolutions to differentiate
             infarcted from noninfarcted myocardium. METHODS AND RESULTS:
             Magnetic resonance imaging was performed at 2.0 T on cross
             sections taken from 10 autopsied hearts containing old
             myocardial infarcts. T1 was derived from six images with
             repetition times (TRs) for each image ranging from 100 to
             3200 milliseconds. T2 was derived from multi-echo images
             with echo times (TEs) ranging from 10 to 60 milliseconds.
             Resolution was approximately 400 x 400 microns in 2-mm-thick
             slices. Sites of infarcted and noninfarcted tissue were
             identified from histological sections taken from each slice,
             and the T1 and T2 values of these sites were obtained.
             Microscopic images were acquired with voxels of 100 x 100 x
             625 microns, representing tissue volumes more than 1000-fold
             smaller than conventional clinical images. In all cases, T1
             of infarcted tissue (459 +/- 266 milliseconds, mean +/- SD)
             was greater than that of noninfarcted tissue (272 +/- 163
             milliseconds). Also, in all cases, T2 of infarcted tissue
             (49 +/- 14 milliseconds) was greater than that of
             noninfarcted tissue (35 +/- 8 milliseconds). CONCLUSIONS: T1
             and T2 values for infarcted tissue are significantly
             different from those of noninfarcted tissue (P < .001).
             Based on these findings, it should be possible to develop
             techniques to perform three-dimensional imaging and
             quantitation of infarcts with a resolution of 400 microns or
             less. When volumetric three-dimensional imaging was
             performed using a T1-weighted sequence, the resulting 256(3)
             arrays supported isotropic resolution at 400 microns (voxel
             volume, 0.064 mm3). Subsequent volume rendering using a
             compositing algorithm clearly shows the infarcted areas in
             three dimensions. The techniques demonstrate the potential
             for quantitative three-dimensional cardiac morphometry using
             magnetic resonance imaging.},
   Key = {fds132827}
}

@booklet{Parmananda94,
   Author = {P. Parmananda and M. A. Rhode and G. A. Johnson and R. W.
             Rollins and H. D. Dewald and A. J. Markworth},
   Title = {Stabilization of unstable steady-states in an
             electrochemical system using derivative control},
   Journal = {Physical Review E},
   Volume = {49},
   Number = {6},
   Pages = {5007 -- 5013},
   Year = {1994},
   Month = {June},
   Key = {Parmananda94}
}

@booklet{Zhou94,
   Author = {X. H. Zhou and R. R. Maronpot and G. P. Cofer and L. W.
             Hedlund and G. A. Johnson},
   Title = {Studies on bromobenzene-induced hepatotoxicity using in-vivo
             mr microscopy with surgically implanted rf
             coils},
   Journal = {Magnetic Resonance In Medicine},
   Volume = {31},
   Number = {6},
   Pages = {619 -- 627},
   Year = {1994},
   Month = {June},
   Key = {Zhou94}
}

@booklet{Ackerman94,
   Author = {R. C. Ackerman and G. A. Johnson and E. A. Vankirk and A. L.
             Asirvatham and W. J. Murdoch},
   Title = {Induction of apoptotic or lytic death in an ovarian
             adenocarcinoma cell-line by antibodies generated against a
             synthetic n-terminal extracellular domain
             gonadotropin-releasing-hormone receptor peptide},
   Journal = {Cancer Letters},
   Volume = {81},
   Number = {2},
   Pages = {177 -- 184},
   Year = {1994},
   Month = {June},
   Key = {Ackerman94}
}

@article{fds132901,
   Author = {P Parmananda and MA Rhode and GA Johnson and RW Rollins and HD Dewald and AJ Markworth},
   Title = {Stabilization of unstable steady states in an
             electrochemical system using derivative control.},
   Journal = {Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip
             Topics},
   Volume = {49},
   Number = {6},
   Pages = {5007-5011},
   Year = {1994},
   Month = {June},
   ISSN = {1063-651X},
   Key = {fds132901}
}

@article{fds269021,
   Author = {Zhou, X and Maronpot, RR and Cofer, GP and Hedlund, LW and Johnson,
             GA},
   Title = {Studies on bromobenzene-induced hepatotoxicity using in vivo
             MR microscopy with surgically implanted RF
             coils.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {31},
   Number = {6},
   Pages = {619-627},
   Year = {1994},
   Month = {June},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8057814},
   Keywords = {Animals • Bromobenzenes • Electromagnetics •
             Equipment Design • Female • Image Enhancement
             • Liver • Magnetic Resonance Imaging •
             Microscopy • Necrosis • Prostheses and Implants
             • Rats • Rats, Inbred F344 • adverse effects*
             • drug effects* • instrumentation • methods
             • methods* • pathology},
   Abstract = {Using surgically implanted RF coils at 300 MHz,
             three-dimensional microscopic MR images of rat liver were
             obtained in vivo to follow the development of pathology
             induced by bromobenzene exposure. Formalin fixed specimens
             of liver from these animals were also imaged using in vitro
             MR microscopy, followed by conventional optical microscopy.
             All MR images were acquired using a spin-warp pulse sequence
             with TR = 950 ms and TE = 23 ms. The in vivo images were
             reconstructed as 256(2) x 32 arrays with a voxel size of (50
             microns)2 x 219 microns, while the in vitro images were
             reconstructed as 256(2) x 128 arrays, giving an isotropic
             resolution at (39 microns)3. Based on results from six
             animals, we have found in all animals exposed to
             bromobenzene, image intensity decreased in specific hepatic
             tissue regions. These regions were well correlated to low
             signal intensity areas observed in in vitro MR images at
             higher resolution. Conventional optical microscopy indicated
             that the low signal intensity regions corresponded to areas
             of necrosis. The decrease in signal intensity is consistent
             with increased local diffusion coefficients as a result of
             necrosis. This study demonstrates that MR microscopy with
             implanted RF coils can be successfully used to follow tissue
             pathological changes in living tissues.},
   Key = {fds269021}
}

@article{fds174153,
   Author = {RC Ackerman and GA Johnson and EA Van Kirk and AL Asirvatham and WJ
             Murdoch},
   Title = {Induction of apoptotic or lytic death in an ovarian
             adenocarcinoma cell line by antibodies generated against a
             synthetic N-terminal extracellular domain
             gonadotropin-releasing hormone receptor peptide.},
   Journal = {Cancer letters},
   Volume = {81},
   Number = {2},
   Pages = {177-84},
   Year = {1994},
   Month = {June},
   ISSN = {0304-3835},
   Keywords = {Adenocarcinoma • Amino Acid Sequence • Animals
             • Apoptosis* • Cytotoxicity, Immunologic •
             Female • Humans • Immune Sera • Mice •
             Molecular Sequence Data • Ovarian Neoplasms •
             Peptide Fragments • Receptors, LHRH • Sheep •
             Tumor Cells, Cultured • immunology* •
             pathology*},
   Abstract = {A polyclonal antiserum was generated in ovariectomized sheep
             against a synthetic peptide corresponding to amino acids
             5-17 of the deduced mouse pituitary gonadotropin-releasing
             hormone (GnRH) receptor. Antipeptide antibodies did not bind
             native cells, but did react strongly with a human ovarian
             cancer cell line (OVCAR-3) reportedly sensitive to GnRH.
             Growth of cultured OVCAR-3 cells was specifically suppressed
             by antipeptide serum. This was attributed in part to
             programmed death (chromatin condensation and DNA
             fragmentation) of cells by antibody-induced apoptosis.
             Antibodies also exhibited a cytolytic effect (lactate
             dehydrogenase release) toward OVCAR-3 cells in the presence
             of the complement. Endometria of passively immunized mice
             lacked development; thus, antipeptide antibodies evidently
             recognize Mullerian duct derivatives. Experiments are in
             progress to determine whether the putative antigen is a
             variant of the pituitary GnRH receptor or a largely
             dissimilar protein. Effector-functional antibodies could be
             useful in the management of ovarian or uterine
             neoplasia.},
   Language = {eng},
   Key = {fds174153}
}

@booklet{Kawabe94,
   Author = {T. T. Kawabe and M. F. Kubicek and G. A. Johnson and A. E.
             Buhl},
   Title = {Use of gamma-glutamyl-transpeptidase activity as a marker of
             hair cycle and anagen induction in mouse
             hair-follicles},
   Journal = {Journal Of Investigative Dermatology},
   Volume = {103},
   Number = {1},
   Pages = {122 -- 126},
   Year = {1994},
   Month = {July},
   Key = {Kawabe94}
}

@article{fds174219,
   Author = {TT Kawabe and MF Kubicek and GA Johnson and AE Buhl},
   Title = {Use of gamma-glutamyl transpeptidase activity as a marker of
             hair cycle and anagen induction in mouse hair
             follicles.},
   Journal = {The Journal of investigative dermatology},
   Volume = {103},
   Number = {1},
   Pages = {122-6},
   Year = {1994},
   Month = {July},
   ISSN = {0022-202X},
   Keywords = {Animals • Biological Markers • Cell Cycle •
             Dose-Response Relationship, Drug • Female • Hair
             • Histocytochemistry • Male • Mice •
             Minoxidil • analysis • analysis* • cytology*
             • drug effects • enzymology* •
             gamma-Glutamyltransferase • pharmacology •
             physiology},
   Abstract = {gamma-glutamyl transpeptidase activity was monitored in
             cycling mice by histologic localization and biochemical
             assay. Our objective for this study is to establish the
             relationship between gamma-glutamyl transpeptidase activity
             and hair growth and to determine whether its activity can be
             correlated to induced hair growth. In cycling mouse skin,
             gamma-glutamyl transpeptidase activity is pronounced during
             anagen and greatly diminished during telogen. In the skin,
             the enzyme is present exclusively in the outer and inner
             root sheaths of hair follicles. gamma-glutamyl
             transpeptidase is limited to the follicle below the level of
             the sebaceous gland and is completely absent in the follicle
             above the sebaceous gland level. During anagen, the outer
             root sheath in the hypodermis is intensely positive for
             gamma-glutamyl transpeptidase activity whereas the hair
             matrix cells and dermal papillar are negative. The inner
             root sheath above the bulb shows distinctive membrane
             staining for gamma-glutamyl transpeptidase. gamma-glutamyl
             transpeptidase activity can be seen to vary only in cycling
             follicles. Inducing anagen by plucking hair shafts results
             in an increase in gamma-glutamyl transpeptidase activity
             directly correlated to hair regrowth. In a similar manner,
             mice were plucked and treated with a daily dose of 2%
             minoxidil. A slight difference in cycle lengths was seen in
             animals treated with minoxidil when compared to vehicle
             control. Minoxidil treatment may cause an early initiation
             of anagen, but both the minoxidil-treated skin and the
             vehicle-treated skin entered telogen at the same time.
             Together, these studies indicate that gamma-glutamyl
             transpeptidase is a specific marker of anagen in growing
             hair.},
   Language = {eng},
   Key = {fds174219}
}

@booklet{Mellin94,
   Author = {MELLIN, AF and COFER, GP and SMITH, BR and SUDDARTH, SA and HEDLUND, LW and JOHNSON, GA},
   Title = {3-DIMENSIONAL MAGNETIC-RESONANCE MICROANGIOGRAPHY OF RAT
             NEUROVASCULATURE},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {32},
   Number = {2},
   Pages = {199-205},
   Year = {1994},
   Month = {August},
   ISSN = {0740-3194},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994NZ79300007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1002/mrm.1910320208},
   Key = {Mellin94}
}

@article{fds268890,
   Author = {Mellin, AF and Cofer, GP and Smith, BR and Suddarth, SA and Hedlund, LW and Johnson, GA},
   Title = {Three dimensional magnetic resonance microangiography of rat
             neurovasculature.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {32},
   Number = {2},
   Pages = {199-205},
   Year = {1994},
   Month = {August},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/7968442},
   Keywords = {Animals • Contrast Media • Gadolinium DTPA •
             Image Processing, Computer-Assisted* • Magnetic
             Resonance Angiography* • Microcirculation •
             Nervous System • Organometallic Compounds •
             Pentetic Acid • Rats • Rats, Sprague-Dawley •
             Serum Albumin, Bovine • analogs & derivatives •
             anatomy & histology • blood supply* • diagnostic
             use},
   Abstract = {Techniques are described to perform three dimensional (3D)
             MR microangiography. We have combined the use of a blood
             pool agent (Gd-DTPA-complexed with bovine serum albumin),
             three dimensional Fourier encoding, careful animal
             stabilization, and volume rendering to permit imaging with
             voxels of 60 x 60 x 60 microns. 3DFT encoding has been
             performed at 7.1 T with very large arrays (256 x 512 x 512).
             Interactive volume rendering allows a number of unique
             display opportunities that effectively exploit these
             isotropic 3D arrays.},
   Key = {fds268890}
}

@booklet{Asirvatham94,
   Author = {A. L. Asirvatham and G. A. Johnson and E. L. Belden and E.
             A. Vankirk and G. E. Moss and W. J. Murdoch},
   Title = {Immunization of mice against a synthetic n-terminal
             extracellular domain gonadotropin-releasing-hormone receptor
             peptide - evidence for a direct uterine effect},
   Journal = {American Journal Of Reproductive Immunology},
   Volume = {32},
   Number = {2},
   Pages = {95 -- 100},
   Year = {1994},
   Month = {September},
   Key = {Asirvatham94}
}

@booklet{Arnder94,
   Author = {L. Arnder and X. H. Zhou and G. P. Cofer and L. W. Hedlund and G. A. Johnson},
   Title = {Magnetic-resonance microscopy of the rat carotid-artery at
             300-megahertz},
   Journal = {Investigative Radiology},
   Volume = {29},
   Number = {9},
   Pages = {822 -- 826},
   Year = {1994},
   Month = {September},
   Key = {Arnder94}
}

@article{fds174276,
   Author = {AL Asirvatham and GA Johnson and EL Belden and EA Van Kirk and GE Moss and WJ Murdoch},
   Title = {Immunization of mice against a synthetic N-terminal
             extracellular domain gonadotropin-releasing hormone receptor
             peptide: evidence for a direct uterine effect.},
   Journal = {American journal of reproductive immunology (New York, N.Y.
             : 1989)},
   Volume = {32},
   Number = {2},
   Pages = {95-100},
   Year = {1994},
   Month = {September},
   ISSN = {1046-7408},
   Keywords = {Amino Acid Sequence • Animals • Female •
             Immunization, Passive • Male • Mice • Mice,
             Inbred BALB C • Molecular Sequence Data • Peptide
             Fragments • Receptors, LHRH • Uterus •
             Vaccination • chemistry • immunology •
             immunology* • pathology},
   Abstract = {PROBLEM: Immature male and female mice were immunized with a
             synthetic peptide corresponding to amino acids 5-17
             (ASLEQDPNHCSAI) of the mouse hypophyseal
             gonadotropin-releasing hormone (GnRH) receptor. METHOD:
             Effect of immunization (postpuberal) was restricted to the
             uterus. Pituitary-gonadal functions were not altered.
             RESULTS: The endometrial lining of immunized females was
             thin and lacked glandular development. These observations
             were corroborated in actively immunized and passively
             immunized adult females. CONCLUSIONS: Apparently endometrial
             cells express a unique surface antigen, though reactive with
             antipeptide antibodies, that differs from the prototype
             pituitary GnRH receptor. Antibodies that selectively inhibit
             endometrial maturation might be used to treat proliferative
             diseases of the uterus.},
   Language = {eng},
   Key = {fds174276}
}

@article{fds268911,
   Author = {Arnder, L and Zhou, X and Cofer, GP and Hedlund, LW and Johnson,
             GA},
   Title = {Magnetic resonance microscopy of the rat carotid artery at
             300 megahertz.},
   Journal = {Investigative Radiology},
   Volume = {29},
   Number = {9},
   Pages = {822-826},
   Year = {1994},
   Month = {September},
   ISSN = {0020-9996},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/7995700},
   Keywords = {Angioplasty, Balloon • Animals • Arteriosclerosis
             • Carotid Arteries • Carotid Artery Diseases
             • Female • Magnetic Resonance Angiography •
             Microscopy • Rats • Rats, Sprague-Dawley •
             diagnosis • methods* • pathology* •
             therapy},
   Abstract = {RATIONALE AND OBJECTIVES: Magnetic resonance microscopy
             (MRM) has evolved from a technical curiosity to a tool with
             which researchers can study important disease models. But
             MRM is not simply an extension of clinical magnetic
             resonance imaging. In this article, the unique adaptations
             of MRM required in the study of carotid artery disease are
             outlined. The techniques of MRM are integrated into a
             specific model of carotid artery disease in the rat to allow
             in vivo studies of vascular wall thickening after removal of
             the vascular endothelium. METHODS: Imaging was performed at
             300 MHz in 250-gm Sprague-Dawley rats using surgically
             implanted radiofrequency coils to localize the region of
             interest and to provide an increase in the signal-to-noise
             ratio over that of volume or surface coils. A
             three-dimensional Fourier encoding sequence was modified
             with flow-dephasing gradients to minimize signal and
             artifacts from moving blood. RESULTS: In vivo images were
             acquired with spatial resolution of 25 x 25 x 400 microns
             and signal-to-noise ratio more than sufficient to define the
             morphology of the vascular wall. Significant changes in the
             intensity and distribution of signal were visible in the
             area surrounding the vessel after angioplasty. CONCLUSIONS:
             Signal-to-noise improvements from surgically implanted coils
             coupled to a three-dimensional radiofrequency-refocused
             sequence with flow-dephasing gradients were sufficient to
             define the wall of the carotid artery. The
             diffusion-weighted pulse sequence detects signal changes in
             the area surrounding the vessel after angioplasty. The MRM
             techniques described and the contrast observed allow us, for
             the first time to follow in vivo the early stage of
             developing atherosclerosis in the vessel wall and closely
             surrounding tissue.},
   Key = {fds268911}
}

@booklet{Kudlacek94,
   Author = {P. E. Kudlacek and R. J. Anderson and G. A.
             Johnson},
   Title = {Sulfation of minoxidil by human platelet thermolabile phenol
             sulfotransferase (tl pst)},
   Journal = {Clinical Research},
   Volume = {42},
   Number = {3},
   Pages = {A394 -- A394},
   Year = {1994},
   Month = {October},
   Key = {Kudlacek94}
}

@booklet{Johnson94,
   Author = {G. A. Johnson and D. M. Tramaglini and R. E. Levine and K.
             Ohno and N. Y. Choi and S. L. Y. Woo},
   Title = {Tensile and viscoelastic properties of human patellar
             tendon},
   Journal = {Journal Of Orthopaedic Research},
   Volume = {12},
   Number = {6},
   Pages = {796 -- 803},
   Year = {1994},
   Month = {November},
   Key = {Johnson94}
}

@booklet{Monk94,
   Author = {B. J. Monk and J. A. Chapman and G. A. Johnson and B. K.
             Brightman and S. P. Wilczynski and M. J. Schell and H.
             Fan},
   Title = {Correlation of c-myc and her-2/neu amplification and
             expression with histopathologic variables in uterine corpus
             cancer},
   Journal = {American Journal Of Obstetrics And Gynecology},
   Volume = {171},
   Number = {5},
   Pages = {1193 -- 1198},
   Year = {1994},
   Month = {November},
   Key = {Monk94}
}

@article{fds174109,
   Author = {BJ Monk and JA Chapman and GA Johnson and BK Brightman and SP
             Wilczynski, MJ Schell and H Fan},
   Title = {Correlation of C-myc and HER-2/neu amplification and
             expression with histopathologic variables in uterine corpus
             cancer.},
   Journal = {American journal of obstetrics and gynecology},
   Volume = {171},
   Number = {5},
   Pages = {1193-8},
   Year = {1994},
   Month = {November},
   ISSN = {0002-9378},
   Keywords = {Adenocarcinoma • Aged • Autoradiography •
             Blotting, Northern • Blotting, Southern • Female
             • Gene Amplification* • Gene Expression* •
             Genes, erbB-2* • Genes, myc* • Humans •
             Middle Aged • Uterine Neoplasms • genetics* •
             pathology • pathology*},
   Abstract = {OBJECTIVE: Initial studies of protooncogenes in uterine
             corpus cancer have focused on a single aspect of the gene in
             question (deoxyribonucleic acid, ribonucleic acid, protein)
             or have studied a small number of patients. Therefore we
             evaluated c-myc and HER-2/neu gene amplification and
             ribonucleic acid overexpression in such malignancies and
             correlated these molecular changes with known pathologic
             risk factors. STUDY DESIGN: Quantitative Southern blot
             analysis for oncogene deoxyribonucleic acid was used to
             examine 37 tumors from patients with primary untreated
             uterine corpus cancer referred to the City of Hope National
             Medical Center. Six normal endometrial specimens were
             controls. Seventeen tumors were also examined by Northern
             blotting to assess increased ribonucleic expression.
             RESULTS: Histologic types included adenocarcinoma (n = 30),
             papillary serous adenocarcinoma (n = 2), adenosquamous
             carcinoma (n = 2), mixed mullerian sarcoma (n = 2), and
             leiomyosarcoma (n = 1). Carcinomas were stage I (n = 10), II
             (n = 18), or III (n = 6). Twenty-three had myometrial
             invasion of less than one third, six one third to two
             thirds, and eight deeper invasion (greater than two thirds).
             According to the criteria of the International Federation of
             Gynecology and Obstetrics stage was as follows: I (n = 22),
             II (n = 3), III (n = 7), and IV (n = 5). Ten (27%) and four
             (11%) tumors showed gene amplification of c-myc and
             HER-2/neu, respectively. Six demonstrated overexpression of
             either the c-myc or HER-2/neu gene. HER-2/neu gene
             amplification was associated more closely with
             overexpression. Stepwise logistic analysis demonstrated
             c-myc amplification to be associated with higher grade (p =
             0.01). CONCLUSION: In this referral population, c-myc
             activation is more common than HER-2/neu activation in
             uterine corpus cancer and is associated with tumors of
             higher grade.},
   Language = {eng},
   Key = {fds174109}
}

@article{fds174213,
   Author = {GA Johnson and DM Tramaglini and RE Levine and K Ohno and NY Choi and SL
             Woo},
   Title = {Tensile and viscoelastic properties of human patellar
             tendon.},
   Journal = {Journal of orthopaedic research : official publication of
             the Orthopaedic Research Society},
   Volume = {12},
   Number = {6},
   Pages = {796-803},
   Year = {1994},
   Month = {November},
   ISSN = {0736-0266},
   url = {http://dx.doi.org/10.1002/jor.1100120607},
   Keywords = {Adult • Aged • Aged, 80 and over • Aging
             • Elasticity • Humans • Middle Aged •
             Muscle Contraction* • Muscle Relaxation • Patella
             • Stress, Mechanical • Tendons • Viscosity
             • physiology • physiology*},
   Abstract = {The tensile and viscoelastic properties of fresh-frozen,
             nonirradiated human patellar tendon were investigated in two
             groups of 15 specimens: one group was from individuals 29-50
             years old and the other group was from individuals 64-93
             years old. The central portion of each patella-patellar
             tendon-tibia complex was subjected to cyclic
             preconditioning, stress-relaxation, cyclic
             stress-relaxation, and load to failure tests. For each age
             group, stress-relaxation and stress-strain curves were
             obtained, from which percentage relaxation, ultimate tensile
             strength, strain at failure, modulus, and strain energy
             density were determined. Viscoelastic behavior was described
             with use of quasilinear viscoelasticity. The younger group
             showed a 46 +/- 9% (mean +/- SD) decrease in stress after 15
             minutes, whereas the older group exhibited a 50 +/- 6%
             decrease. The values for ultimate tensile strength and
             strain at failure, respectively, were 64.7 +/- 15.0 MPa and
             14 +/- 6% for the younger group and 53.6 +/- 10.0 MPa and 15
             +/- 5% for the older group. Modulus values were 660 +/- 266
             MPa for the younger group and 504 +/- 222 MPa for the older
             group. Except for ultimate tensile strength, which was 17%
             less for the older group than for the younger one, no
             statistically significant differences were found in tensile
             or viscoelastic properties. This study indicated that there
             were minimal differences in biomechanical properties of the
             substance of the patellar tendon between younger and older
             age groups.},
   Language = {eng},
   Doi = {10.1002/jor.1100120607},
   Key = {fds174213}
}

@booklet{Johnson95,
   Author = {G. A. Johnson and D. A. Mortensen and L. J. Young and A. R.
             Martin},
   Title = {The stability of weed seedling population-models and
             parameters in eastern nebraska corn (zea-mays) and soybean
             (glycine-max) fields},
   Journal = {Weed Science},
   Volume = {43},
   Number = {4},
   Pages = {604 -- 611},
   Year = {1995},
   Key = {Johnson95}
}

@booklet{Black95,
   Author = {Black, RD and Early, TA and Johnson, GA},
   Title = {Performance of a High-Temperature Superconducting Resonator
             for High-Field Imaging},
   Journal = {Journal of Magnetic Resonance - Series A},
   Volume = {113},
   Number = {1},
   Pages = {74-80},
   Year = {1995},
   ISSN = {1064-1858},
   url = {http://dx.doi.org/10.1006/jmra.1995.1058},
   Abstract = {The practicalities involved with the use of a
             superconducting microimaging probe are outlined so that the
             power and problems associated with this technology can be
             assessed. The nonlinearity of the transmission
             characteristics of this class of probe, the intrinsic limits
             on bandwidth, the long ring-down times, the potential for
             spin damping, and the difficulties of suppressing Johnson
             noise are all discussed. Recent refinements that have
             delivered a factor of 30 gain in SNR (signal-to-noise ratio)
             relative to copper coils at room temperature are presented.
             Further reductions in noise sources should yield a gain of a
             factor of 60 in SNR. © 1995 Academic Press. All rights
             reserved.},
   Doi = {10.1006/jmra.1995.1058},
   Key = {Black95}
}

@booklet{Johnson95c,
   Author = {G. A. Johnson and T. R. Hansen and K. J. Austin and E. A.
             Vankirk and W. J. Murdoch},
   Title = {Baculovirus-insect cell production of bioactive
             choriogonadotropin-immunoglobulin-g heavy-chain fusion
             proteins in sheep},
   Journal = {Biology Of Reproduction},
   Volume = {52},
   Number = {1},
   Pages = {68 -- 73},
   Year = {1995},
   Month = {January},
   Key = {Johnson95c}
}

@article{fds174293,
   Author = {GA Johnson and TR Hansen and KJ Austin and EA Van Kirk and WJ
             Murdoch},
   Title = {Baculovirus-insect cell production of bioactive
             choriogonadotropin-immunoglobulin G heavy-chain fusion
             proteins in sheep.},
   Journal = {Biology of reproduction},
   Volume = {52},
   Number = {1},
   Pages = {68-73},
   Year = {1995},
   Month = {January},
   ISSN = {0006-3363},
   Keywords = {Animals • Base Sequence • Cell Line •
             Chorionic Gonadotropin • DNA Primers • DNA,
             Complementary • Immunoglobulin G • Immunoglobulin
             Heavy Chains • Male • Mice • Molecular
             Sequence Data • Nucleopolyhedrovirus • Recombinant
             Fusion Proteins • Sheep • Spodoptera • Testis
             • Testosterone • Tumor Cells, Cultured •
             biosynthesis • biosynthesis* • blood • drug
             effects • genetics • pathology •
             pharmacology},
   Abstract = {A hybrid cDNA encoding a fusion protein between the beta
             subunit of hCG (beta hCG) and constant domains of a mouse
             IgG heavy chain (CH1-3) was inserted into a baculovirus
             expression vector. Insect cells transfected with foreign DNA
             synthesized multimeric forms of fusion protein that
             inhibited hCG-induced steroid hormone secretion by mouse
             Leydig tumor cells. Leydig cells were lysed by beta
             hCG-CH1-3 in the presence of complement. Intravenous
             injection of beta hCG-CH1-3 in rams was associated with
             testicular mononuclear leukocyte infiltration, interstitial
             tissue damage, and a transient depression in circulatory
             testosterone (levels returned to normal within 2 wk). It
             appears that targeted cell-killing can be mediated by
             recombinant proteins composed of the receptor-binding moiety
             of hormones and truncated effector (Fc) regions of lethal
             antibodies.},
   Language = {eng},
   Key = {fds174293}
}

@article{fds174162,
   Author = {CH Nielsen and GA Johnson},
   Title = {The experience of complete neuromuscular blockade in awake
             patients.},
   Journal = {Journal of clinical anesthesia},
   Volume = {6},
   Number = {5},
   Pages = {450},
   Year = {1995},
   Month = {January},
   ISSN = {0952-8180},
   Keywords = {Awareness* • Humans • Ketamine • Lung •
             Neuromuscular Blocking Agents • Oxygen •
             Positive-Pressure Respiration • Pulmonary Atelectasis
             • Tidal Volume • administration & dosage •
             administration & dosage* • blood* • chemically
             induced • drug effects • pharmacology •
             physiopathology},
   Language = {eng},
   Key = {fds174162}
}

@booklet{Middleton95,
   Author = {H. Middleton and R. D. Black and B. Saam and G. D. Cates and G. P. Cofer and R. Guenther and W. Happer and L. W. Hedlund and G. A. Johnson and K. Juvan and J. Swartz},
   Title = {Mr-imaging with hyperpolarized he-3 gas},
   Journal = {Magnetic Resonance In Medicine},
   Volume = {33},
   Number = {2},
   Pages = {271 -- 275},
   Year = {1995},
   Month = {February},
   Key = {Middleton95}
}

@article{fds269110,
   Author = {Middleton, H and Black, RD and Saam, B and Cates, GD and Cofer, GP and Guenther, R and Happer, W and Hedlund, LW and Johnson, GA and Juvan,
             K},
   Title = {MR imaging with hyperpolarized 3He gas.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {33},
   Number = {2},
   Pages = {271-275},
   Year = {1995},
   Month = {February},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/7707920},
   Keywords = {Animals • Guinea Pigs • Helium • Image
             Enhancement • Lasers • Lung • Magnetic
             Resonance Imaging* • Magnetic Resonance Spectroscopy
             • Rubidium • Time Factors • anatomy &
             histology* • chemistry • diagnostic use* •
             metabolism • methods • radiation
             effects},
   Abstract = {Magnetic resonance images of the lungs of a guinea pig have
             been produced using hyperpolarized helium as the source of
             the MR signal. The resulting images are not yet sufficiently
             optimized to reveal fine structural detail within the lung,
             but the spectacular signal from this normally
             signal-deficient organ system offers great promise for
             eventual in vivo imaging experiments. Fast 2D and 3D GRASS
             sequences with very small flip angles were employed to
             conserve the norenewable longitudinal magnetization. We
             discuss various unique features associated with performing
             MRI with hyperpolarized gases, such as the selection of the
             noble gas species, polarization technique, and constraints
             on the MR pulse sequence.},
   Key = {fds269110}
}

@booklet{Burvill95,
   Author = {P. W. Burvill and G. A. Johnson and K. D. Jamrozik and C. S.
             Anderson and E. G. Stewartwynne and T. M. H.
             Chakera},
   Title = {Prevalence of depression after stroke - the perth community
             stroke study},
   Journal = {British Journal Of Psychiatry},
   Volume = {166},
   Pages = {320 -- 327},
   Year = {1995},
   Month = {March},
   Key = {Burvill95}
}

@booklet{Johnson95b,
   Author = {G. A. Johnson and M. Locher and E. R. Hunt},
   Title = {Stabilized spatiotemporal waves in a convectively unstable
             open flow system - coupled diode resonators},
   Journal = {Physical Review E},
   Volume = {51},
   Number = {3},
   Pages = {R1625 -- R1628},
   Year = {1995},
   Month = {March},
   Key = {Johnson95b}
}

@booklet{Burvill95a,
   Author = {P. W. Burvill and G. A. Johnson and K. D. Jamrozik and C. S.
             Anderson and E. G. Stewartwynne and T. M. H.
             Chakera},
   Title = {Anxiety disorders after stroke - results from the perth
             community stroke study},
   Journal = {British Journal Of Psychiatry},
   Volume = {166},
   Pages = {328 -- 332},
   Year = {1995},
   Month = {March},
   Key = {Burvill95a}
}

@article{fds132912,
   Author = {GA Johnson and M Löcher and ER Hunt},
   Title = {Stabilized spatiotemporal waves in a convectively unstable
             open flow system: coupled diode resonators.},
   Journal = {Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip
             Topics},
   Volume = {51},
   Number = {3},
   Pages = {R1625-R1628},
   Year = {1995},
   Month = {March},
   ISSN = {1063-651X},
   Key = {fds132912}
}

@article{fds174205,
   Author = {PW Burvill and GA Johnson and KD Jamrozik and CS Anderson and EG
             Stewart-Wynne, TM Chakera},
   Title = {Prevalence of depression after stroke: the Perth Community
             Stroke Study.},
   Journal = {The British journal of psychiatry : the journal of mental
             science},
   Volume = {166},
   Number = {3},
   Pages = {320-7},
   Year = {1995},
   Month = {March},
   ISSN = {0007-1250},
   Keywords = {Adaptation, Psychological • Adult • Aged •
             Aged, 80 and over • Cerebrovascular Disorders •
             Cohort Studies • Cross-Sectional Studies •
             Delirium, Dementia, Amnestic, Cognitive Disorders •
             Depressive Disorder • Female • Follow-Up Studies
             • Humans • Incidence • Male • Middle
             Aged • Recurrence • Sick Role • Western
             Australia • diagnosis • epidemiology •
             epidemiology* • psychology},
   Abstract = {BACKGROUND: The Perth Community Stroke Study (PCSS) was a
             population-based study of the incidence, cause, and outcome
             of acute stroke. METHOD: Subjects from the study were
             assessed initially, by examination and interview, and at
             four- and 12-month follow-ups to determine differences in
             prevalence of depression between the sexes and between
             patients with first-ever and recurrent strokes. RESULTS: The
             prevalence of depressive illness four months after stroke in
             294 patients from the PCSS was 23% (18-28%), 15% (11-19%)
             major depression and 8% (5-11%) minor depression. There were
             no significant differences between the sexes or between
             patients with first-ever and recurrent strokes. With a
             non-hierarchic approach to diagnosis of those with
             depression, 26% of men and 39% of women had an associated
             anxiety disorder, mainly agoraphobia. Nine per cent of male
             and 13% of female patients interviewed had evidence of
             depression at the time of the stroke. Twelve months after
             stroke 56% of the men were still depressed (40% major and
             16% minor), as were 30% of the women (12% major and 18%
             minor). CONCLUSION: The prevalence of depression after
             stroke was comparable with that reported from other studies,
             and considerably less than that reported from in-patient and
             rehabilitation units.},
   Language = {eng},
   Key = {fds174205}
}

@article{fds174259,
   Author = {PW Burvill and GA Johnson and KD Jamrozik and CS Anderson and EG
             Stewart-Wynne, TM Chakera},
   Title = {Anxiety disorders after stroke: results from the Perth
             Community Stroke Study.},
   Journal = {The British journal of psychiatry : the journal of mental
             science},
   Volume = {166},
   Number = {3},
   Pages = {328-32},
   Year = {1995},
   Month = {March},
   ISSN = {0007-1250},
   Keywords = {Adaptation, Psychological • Adult • Aged •
             Agoraphobia • Anxiety Disorders • Cerebrovascular
             Disorders • Comorbidity • Cross-Sectional Studies
             • Delirium, Dementia, Amnestic, Cognitive Disorders
             • Depressive Disorder • Female • Follow-Up
             Studies • Humans • Incidence • Male •
             Middle Aged • Sick Role • Western Australia •
             diagnosis • epidemiology • epidemiology* •
             psychology},
   Abstract = {BACKGROUND: The prevalence of anxiety disorders in 294
             patients who survived to four months in the Perth Community
             Stroke Study (Perth, Australia), and a follow-up of these
             patients at 12 months, are presented. METHOD: Diagnoses are
             described both in the usual DSM hierarchic format and by a
             non-hierarchic approach. Adoption of the hierarchic approach
             alone greatly underestimates the prevalence of anxiety
             disorders. RESULTS: Most cases were of agoraphobia, and the
             remainder were generalised anxiety disorder. The prevalence
             of anxiety disorders alone was 5% in men and 19% in women;
             in community controls, it was 5% in men and 8% in women.
             Adopting a non-hierarchic approach to diagnosis gave a
             prevalence of 12% in men and 28% in women. When those who
             showed evidence of anxiety disorder before stroke were
             subtracted, the latter prevalence was 9% in men and 20% in
             women. CONCLUSION: One-third of the men and half of the
             women with post-stroke anxiety disorders showed evidence of
             either depression or an anxiety disorder at the time of the
             stroke. At 12 month follow-up of 49 patients with
             agoraphobia by a non-hierarchic approach, 51% had recovered,
             and equal proportions of the remainder had died or still had
             agoraphobia. The only major difference in outcome between
             those with anxiety disorder alone and those with comorbid
             depression was the greater mortality in the
             latter.},
   Language = {eng},
   Key = {fds174259}
}

@booklet{Kudlacek95,
   Author = {P. E. Kudlacek and R. J. Anderson and D. K. Liebentritt and G. A. Johnson and C. J. Huerter},
   Title = {Human skin and platelet minoxidil sulfotransferase
             activities - biochemical-properties, correlations and
             contribution of thermolabile phenol sulfotransferase},
   Journal = {Journal Of Pharmacology And Experimental
             Therapeutics},
   Volume = {273},
   Number = {2},
   Pages = {582 -- 590},
   Year = {1995},
   Month = {May},
   Key = {Kudlacek95}
}

@article{fds174118,
   Author = {PE Kudlacek and RJ Anderson and DK Liebentritt and GA Johnson and CJ
             Huerter},
   Title = {Human skin and platelet minoxidil sulfotransferase
             activities: biochemical properties, correlations and
             contribution of thermolabile phenol sulfotransferase.},
   Journal = {The Journal of pharmacology and experimental
             therapeutics},
   Volume = {273},
   Number = {2},
   Pages = {582-90},
   Year = {1995},
   Month = {May},
   ISSN = {0022-3565},
   Keywords = {Arylsulfotransferase • Blood Platelets •
             Chromatography, High Pressure Liquid • Chromatography,
             Ion Exchange • Enzyme Stability • Humans •
             Minoxidil • Nitrophenols • Skin • Sodium
             Chloride • Substrate Specificity •
             Sulfotransferases • Temperature • antagonists &
             inhibitors • enzymology* • isolation &
             purification • metabolism* • pharmacology},
   Abstract = {Human scalp skin high speed supernatants were used to test
             whether minoxidil sulfotransferase (MNX-ST) and phenol
             sulfotransferase (PST) activities were present. Platelet
             homogenates from the same skin donors were used to test
             whether levels of sulfotransferase activities in the blood
             platelet would reflect levels of the enzyme activities in
             skin. Dopamine, p-nitrophenol and minoxidil were used as
             substrates for skin and platelet thermolabile (TL PST),
             thermostable (TS PST) and MNX-ST activities, respectively.
             Biochemical properties of each skin enzyme were the same as
             the platelet enzymes with respect to apparent Km values for
             substrates, pH optima, thermal stabilities and responses to
             inhibition by 2,6-dichloro-4-nitrophenol (DCNP). An
             unexpected finding was that skin and platelet MNX-ST thermal
             stabilities and responses to DCNP were more similar to TL
             PST than to TS PST, the enzyme reported to be responsible
             for MNX-ST activity. There were significant positive
             correlations of platelet sulfotransferases with the relative
             levels of activities of the same skin sulfotransferases.
             Unexpected findings were significant positive correlations
             of MNX-ST and TL PST activities. Partially purified platelet
             TS PST assayed with minoxidil as the substrate showed a
             response to DCNP and thermal stability that were the same as
             TS PST. Platelet TL PST assayed with minoxidil showed
             thermal stability and a response to DCNP that were
             essentially the same as TL PST. The results indicated that
             not only TS PST, but also TL PST activities in human skin
             and platelet contributed to MNX-ST activity. It will be
             feasible to test whether measures of platelet PST activities
             will predict physiologic responses to minoxidil.},
   Language = {eng},
   Key = {fds174118}
}

@booklet{Johnson95a,
   Author = {G. A. Johnson and D. A. Mortensen and A. R.
             Martin},
   Title = {A simulation of herbicide use based on weed
             spatial-distribution},
   Journal = {Weed Research},
   Volume = {35},
   Number = {3},
   Pages = {197 -- 205},
   Year = {1995},
   Month = {June},
   Key = {Johnson95a}
}

@booklet{Macfall95,
   Author = {MACFALL, IS and JOHNSON, GA},
   Title = {3-DIMENSIONAL ROOT-GROWTH, TURNOVER AND TRANSPORT AS SEEN
             WITH MAGNETIC-RESONANCE MICROSCOPY},
   Journal = {Plant physiology},
   Volume = {108},
   Number = {2},
   Pages = {31-31},
   Year = {1995},
   Month = {June},
   ISSN = {0032-0889},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995RE28900117&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Macfall95}
}

@booklet{Summers95,
   Author = {Summers, RM and Hedlund, LW and Cofer, GP and Gottsman, MB and Manibo,
             JF and Johnson, GA},
   Title = {MR microscopy of the rat carotid artery after balloon injury
             by using an implanted imaging coil.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {33},
   Number = {6},
   Pages = {785-789},
   Year = {1995},
   Month = {June},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/7651114},
   Abstract = {Neointimal hyperplasia after angioplasty was followed in
             vivo in rats by using MR microscopy and surgically implanted
             RF imaging coils. By using an inductively coupled pick-up
             coil, the arteries were imaged 4 days before and 3, 7, and
             14 days after angioplasty with a 3DFT spin echo sequence.
             Eight of 10 angioplastied rats showed moderate to severe
             stensois based MR measures of lumen diameter reduction from
             baseline images. There was a good correlation between total
             wall thickness between MR and hematoxylin and eosin
             (H&E)-stained sections obtained on the last day. Arteries in
             the intact and sham groups remained unchanged from baseline
             measurements. Because this imaging technique examines the
             artery under in vivo conditions of arterial pressure and
             flow, it promises to be a useful tool for evaluating
             pharmacological and mechanical methods of reducing the
             incidence of vascular stenosis.},
   Key = {Summers95}
}

@article{fds132862,
   Author = {RM Summers and LW Hedlund and GP Cofer and MB Gottsman and JF Manibo and GA
             Johnson},
   Title = {MR microscopy of the rat carotid artery after balloon injury
             by using an implanted imaging coil.},
   Journal = {Magnetic resonance in medicine : official journal of the
             Society of Magnetic Resonance in Medicine / Society of
             Magnetic Resonance in Medicine, UNITED STATES},
   Volume = {33},
   Number = {6},
   Pages = {785-9},
   Year = {1995},
   Month = {June},
   ISSN = {0740-3194},
   Keywords = {Angioplasty, Balloon • Animals • Carotid Artery
             Injuries • Carotid Artery, External • Carotid
             Stenosis • Female • Hyperplasia • Magnetic
             Resonance Imaging* • Microscopy • Rats •
             Rats, Sprague-Dawley • Tunica Intima • adverse
             effects* • pathology • pathology* •
             therapy},
   Abstract = {Neointimal hyperplasia after angioplasty was followed in
             vivo in rats by using MR microscopy and surgically implanted
             RF imaging coils. By using an inductively coupled pick-up
             coil, the arteries were imaged 4 days before and 3, 7, and
             14 days after angioplasty with a 3DFT spin echo sequence.
             Eight of 10 angioplastied rats showed moderate to severe
             stensois based MR measures of lumen diameter reduction from
             baseline images. There was a good correlation between total
             wall thickness between MR and hematoxylin and eosin
             (H&E)-stained sections obtained on the last day. Arteries in
             the intact and sham groups remained unchanged from baseline
             measurements. Because this imaging technique examines the
             artery under in vivo conditions of arterial pressure and
             flow, it promises to be a useful tool for evaluating
             pharmacological and mechanical methods of reducing the
             incidence of vascular stenosis.},
   Key = {fds132862}
}

@booklet{Flanagan95,
   Author = {C. W. Flanagan and R. S. Mannel and J. L. Walker and G. A.
             Johnson},
   Title = {Incidence and location of paraaortic lymph-node metastases
             in gynecologic malignancies},
   Journal = {Journal Of The American College Of Surgeons},
   Volume = {181},
   Number = {1},
   Pages = {72 -- 74},
   Year = {1995},
   Month = {July},
   Key = {Flanagan95}
}

@article{fds174241,
   Author = {CW Flanagan and RS Mannel and JL Walker and GA Johnson},
   Title = {Incidence and location of para-aortic lymph node metastases
             in gynecologic malignancies.},
   Journal = {Journal of the American College of Surgeons},
   Volume = {181},
   Number = {1},
   Pages = {72-4},
   Year = {1995},
   Month = {July},
   ISSN = {1072-7515},
   Keywords = {Abdomen • Endometrial Neoplasms • Female •
             Genital Neoplasms, Female • Humans • Lymph Node
             Excision • Lymphatic Metastasis* • Neoplasm
             Staging • Ovarian Neoplasms • Retrospective
             Studies • Uterine Cervical Neoplasms • pathology
             • pathology*},
   Abstract = {BACKGROUND: We sought to determine the location of
             metastases to para-aortic lymph nodes in patients with
             gynecologic malignancies. STUDY DESIGN: A retrospective
             chart review was performed for all cases of endometrial,
             ovarian, and cervical carcinoma in which right and left
             para-aortic lymph node dissection was done at our
             institution from 1985 to 1993. Records were assessed for
             tumor type as well as for presence and location of
             metastases to para-aortic lymph nodes. RESULTS: A total of
             315 patients had bilateral para-aortic lymphadenectomy
             performed at the time of laparotomy as part of staging or
             therapy for their gynecologic malignancies. A total of 47
             patients (15 percent) had metastasis to the para-aortic
             lymph nodes. Para-aortic metastasis were identified in 22
             (30 percent) of 73 patients with ovarian carcinoma, 11 (8
             percent) of 141 patients with cervical carcinoma, and 14 (14
             percent) of 101 patients sampled. Unilateral left-sided
             para-aortic node involvement was observed in 13 patients,
             unilateral right-sided involvement was present in 14
             patients, and bilateral involvement occurred in 20 patients.
             Regarding tumor type or origin, no significant difference
             was noted in right-sided compared with left-sided
             para-aortic metastases. CONCLUSIONS: Our data suggest no
             difference in the incidence of metastases to right-sided
             compared with left para-aortic lymph nodes in patients with
             gynecologic malignancies, emphasizing the need for bilateral
             evaluation of the para-aortic lymph nodes. This information
             is important in the clinical staging of gynecologic
             malignancies and in establishing protocols requiring
             para-aortic lymph node dissection.},
   Language = {eng},
   Key = {fds174241}
}

@booklet{Shattuck95,
   Author = {M. D. Shattuck and R. P. Behringer and G. A. Johnson and J.
             G. Georgiadis},
   Title = {Onset and stability of convection in porous-media -
             visualization by magnetic-resonance-imaging},
   Journal = {Physical Review Letters},
   Volume = {75},
   Number = {10},
   Pages = {1934 -- 1937},
   Year = {1995},
   Month = {September},
   Key = {Shattuck95}
}

@article{fds132859,
   Author = {MD Shattuck and RP Behringer and GA Johnson and JG
             Georgiadis},
   Title = {Onset and Stability of Convection in Porous Media:
             Visualization by Magnetic Resonance Imaging.},
   Journal = {Phys Rev Lett},
   Volume = {75},
   Number = {10},
   Pages = {1934-1937},
   Year = {1995},
   Month = {September},
   ISSN = {0031-9007},
   Key = {fds132859}
}

@booklet{Zhou95,
   Author = {Zhou, X and Maronpot, RR and Hedlund, LW and Cofer, GP and Johnson,
             GA},
   Title = {Detection of bromobenzene-induced hepatocellular necrosis
             using magnetic resonance microscopy.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {34},
   Number = {6},
   Pages = {853-857},
   Year = {1995},
   Month = {December},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8598812},
   Abstract = {The authors used magnetic resonance (MR) microscopy to
             assess hepatic tissue damage induced by bromobenzene both in
             living rats and in fixed rat liver tissues. Experiments were
             conducted at 7 Tesla on three groups of Fisher rats treated
             with bromobenzene at a single dose of 68, 135, and 269
             mg/kg, respectively. Optical microscopy of hematoxylin and
             eosin stained sections showed liver damage only at the
             highest dose, whereas with MR microscopy, tissue alterations
             were detected at all three doses both in vivo and ex vivo.
             The contrast mechanism of the superior sensitivity of MR
             microscopy is believed to be related to the changes in local
             diffusion coefficients that accompany cellular degeneration
             and death, although other contrast mechanisms may also be
             involved. The superior sensitivity of MR microscopy, as
             demonstrated in this study, has many implications for
             potential use of MR techniques to perform in vivo
             histology.},
   Key = {Zhou95}
}

@article{fds132860,
   Author = {X Zhou and RR Maronpot and LW Hedlund and GP Cofer and GA
             Johnson},
   Title = {Detection of bromobenzene-induced hepatocellular necrosis
             using magnetic resonance microscopy.},
   Journal = {Magnetic resonance in medicine : official journal of the
             Society of Magnetic Resonance in Medicine / Society of
             Magnetic Resonance in Medicine, UNITED STATES},
   Volume = {34},
   Number = {6},
   Pages = {853-7},
   Year = {1995},
   Month = {December},
   ISSN = {0740-3194},
   Keywords = {Animals • Bromobenzenes • Dose-Response
             Relationship, Drug • Female • Image Processing,
             Computer-Assisted • Liver • Magnetic Resonance
             Spectroscopy • Necrosis • Rats • Rats, Inbred
             F344 • Sensitivity and Specificity • diagnostic
             use* • drug effects* • methods • pathology
             • toxicity*},
   Abstract = {The authors used magnetic resonance (MR) microscopy to
             assess hepatic tissue damage induced by bromobenzene both in
             living rats and in fixed rat liver tissues. Experiments were
             conducted at 7 Tesla on three groups of Fisher rats treated
             with bromobenzene at a single dose of 68, 135, and 269
             mg/kg, respectively. Optical microscopy of hematoxylin and
             eosin stained sections showed liver damage only at the
             highest dose, whereas with MR microscopy, tissue alterations
             were detected at all three doses both in vivo and ex vivo.
             The contrast mechanism of the superior sensitivity of MR
             microscopy is believed to be related to the changes in local
             diffusion coefficients that accompany cellular degeneration
             and death, although other contrast mechanisms may also be
             involved. The superior sensitivity of MR microscopy, as
             demonstrated in this study, has many implications for
             potential use of MR techniques to perform in vivo
             histology.},
   Key = {fds132860}
}

@booklet{Johnson96c,
   Author = {G. A. Johnson and D. A. Mortensen and C. A.
             Gotway},
   Title = {Spatial and temporal analysis of weed seedling populations
             using geostatistics},
   Journal = {Weed Science},
   Volume = {44},
   Number = {3},
   Pages = {704 -- 710},
   Year = {1996},
   Key = {Johnson96c}
}

@booklet{Johnson96b,
   Author = {G. A. Johnson and D. A. Mortensen and L. J. Young and A. R.
             Martin},
   Title = {Parametric sequential sampling based on multistage
             estimation of the negative binomial parameter
             k},
   Journal = {Weed Science},
   Volume = {44},
   Number = {3},
   Pages = {555 -- 559},
   Year = {1996},
   Key = {Johnson96b}
}

@booklet{Burvill96,
   Author = {P. W. Burvill and G. A. Johnson and T. M. H. Chakera and E.
             G. Stewartwynne and C. S. Anderson and K. D.
             Jamrozik},
   Title = {The place of site of lesion in the aetiology of post-stroke
             depression},
   Journal = {Cerebrovascular Diseases},
   Volume = {6},
   Number = {4},
   Pages = {208 -- 215},
   Year = {1996},
   Key = {Burvill96}
}

@article{fds268799,
   Author = {Johnson, G and Thomson, DJ and Wu, EX and Williams,
             SCR},
   Title = {Multiple-window spectrum estimation applied to in vivo NMR
             spectroscopy},
   Journal = {Journal of Magnetic Resonance, Series B},
   Volume = {110},
   Number = {2},
   Pages = {138-149},
   Year = {1996},
   ISSN = {1064-1866},
   Abstract = {Multiple-window spectrum estimation (MWSE) is a method of
             deriving frequency spectra from time series. A set of
             apodizing windows is applied to the time data and each
             windowed data set is Fourier transformed. The windows are
             prolate spheroidal sequences. These form the orthonormal set
             of functions that is maximally concentrated in both time and
             frequency domains. An iterative algorithm is then applied to
             the data set to find a leastsquares estimate of the power
             spectrum. In addition, statistical tests may be applied to
             determine the existence of periodic components at particular
             frequencies, their amplitudes, phases, and positions. The
             method is quantitative and makes no lineshape assumptions.
             Computer simulations were used to compare MWSE performance
             with that of conventional Fourier-transform processing with
             quantification by curve fitting. Signal-to-noise ratio,
             spectral resolution, linearity, and susceptibility to
             artifacts were compared. MWSE gives similar signal-to-noise
             ratio and spectral resolution to Fourier-transform data and
             is linear over three orders of magnitude but is much more
             robust with respect to artifacts. In particular, data
             truncation introduces no baseline distortion, broad baseline
             humps are removed automatically, and large solvent peaks may
             be easily removed without affecting adjacent lines. No
             separate phase correction is required. MWSE gives more
             accurate quantitative spectra, particularly when the time
             data are imperfect. The method is, therefore, particularly
             appropriate for processing in vivo data. The utility of the
             MWSE method is demonstrated on in vivo 'H, 31P, and 13C NMR
             spectroscopy data. e 1996 Academic Press,
             Inc.},
   Key = {fds268799}
}

@article{fds289612,
   Author = {Engelhardt, RT and Johnson, GA},
   Title = {T1p relaxation and its application to MR
             histology},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {35},
   Number = {5},
   Pages = {781-786},
   Year = {1996},
   Abstract = {The application of T1p as an alternative contrast parameter
             in high-field magnetic resonance histology (MRH) has been
             investigated. Spectroscopic measurements of T1p were
             performed on 5.75% agar and 1.0 mM MnCl2 phantoms at 9.4 T
             to validate the accuracy of the imaging measurements. Image
             studies were performed at 2.0 and 9.4 T on perfusion-fixed
             17.5-day-old mouse embryos. T1, T2, and T1p relaxation times
             were calculated for the phantoms and muscle, diencephalon,
             and liver tissues. The 5.75% agar phantom and all tissues
             showed T1p dispersion with B1L, whereas the 1.0 mM MnCl2
             phantom showed no significant B1L dependence. T1p dispersion
             with B0 was observed arising from the effects of diffusion
             through susceptibility-induced gradients. T1p shows promise
             as a contrast parameter in high-field MRH because it is
             capable of producing T2-like contrast without the
             susceptibility artifacts associated with T2-weighted
             images.},
   Key = {fds289612}
}

@article{fds132718,
   Title = {R.T. Engelhardt, G.A. Johnson, T1r relaxation and its
             application to MR  histology.  Magnetic Resonance in
             Medicine 35, 781-786 (1996).},
   Year = {1996},
   Key = {fds132718}
}

@article{fds132719,
   Title = {L.W. Hedlund, M.D. Shattuck, G.A. Johnson.
              Three-dimensional MR  microscopy of pulmonary dynamics.
              in "Proc., 1996.  New York, NY,  1996,"
             p.327.},
   Year = {1996},
   Key = {fds132719}
}

@article{fds132720,
   Title = {G.A. Johnson, G. Cates, X.J. Chen, G.P. Cofer,  B.
             Driehuys, W. Happer,  L.W. Hedlund, B. Saam, M. Shattuck,
             J. Swartz.  Dynamics of  magnetization in hyperpolarized
             gas MRI of the lung.  Magnetic Resonance  in Medicine
             submitted (1996).},
   Year = {1996},
   Key = {fds132720}
}

@article{fds132721,
   Title = {G.A. Johnson, L.W. Hedlund.  Functional imaging of the
             lung.  Nature  Medicine 2, 1192 (1996).},
   Year = {1996},
   Key = {fds132721}
}

@article{fds132722,
   Title = {J.S. MacFall, G.A. Johnson, in "Encyclopedia of Nuclear
             Magnetic  Resonance" (D.M. Grant, R.K. Harris, Ed.), p.
             3633-3640, John Wiley &  Sons, London, 1996.},
   Year = {1996},
   Key = {fds132722}
}

@article{fds132723,
   Title = {M.D. Shattuck, G.P. Cofer, G.H. Glover, L.W. Hedlund, G.A.
             Johnson.    Three-dimensional projection microscopy of the
             lung. in "Proc., SMR 4th  Scientific Meeting.  New York,
             NY, 1996," p. 18.},
   Year = {1996},
   Key = {fds132723}
}

@article{fds132732,
   Title = {R.D. Black, H. Middleton, G.D. Cates, G.P. Cofer, B.
             Driehuys, W. Happer,   L. W. Hedlund, G.A. Johnson, M.D.
             Shattuck, J. Swartz, In vivo He-3 MR   Images of guinea pig
             lungs.  Radiology 199, 867-870 (1996).},
   Year = {1996},
   Key = {fds132732}
}

@article{fds132733,
   Title = {M. Delnomdedieu, L.W. Hedlund, G.A. Johnson, R.R. Maronpot,
             Magnetic  Resonance Microscopy-A New Tool for the
             Toxicologic Pathologist.   Toxicologic Pathology 24, 36-44
             (1996).},
   Year = {1996},
   Key = {fds132733}
}

@article{fds132734,
   Title = {M. Delnomdedieu, L. W. Hedlund, R.R. Maronpot, G.A. Johnson.
             MR  microscopy to follow bromobenzene-induced hepatoxicity
             in the rat. in  "Proc., SMR 4th Annual Scientific Meeting.
              New York, NY, 1996," p.325.},
   Year = {1996},
   Key = {fds132734}
}

@article{fds132735,
   Title = {W. L. Hall, H. Benveniste, L.W. Hedlund, G.A. Johnson, A new
             in vivo  method for quantitative analysis of stroke lesions
             using MR microscopy.   NeuroImage 3, 158-166
             (1996).},
   Year = {1996},
   Key = {fds132735}
}

@article{fds132736,
   Title = {L.W. Hedlund, S.L. Gewalt, G.P. Cofer, G.A. Johnson, in
             "Application of  Magnetic Resonance to the Study of the
             Lung" (A. Cutillo, Ed.), p. 401-415,  Futura Press, Mt.
             Kisko, NY, 1996.},
   Year = {1996},
   Key = {fds132736}
}

@article{fds132737,
   Title = {S. Hurlston, R.D. Black, W. Brey, X.J. Chen, L.W. Hedlund,
             R. Withers,  M.Yap, G.A. Johnson.  A superconducting
             surface coil for in vivo MR  microscopy. in "Proc., SMR 4th
             Annual Scientific Meeting.  New York, NY,  1996,"
             p.129.},
   Year = {1996},
   Key = {fds132737}
}

@article{fds132738,
   Title = {G.A. Johnson, H. Beneveniste, R.T. Engelhardt, H. Qiu, L. W.
             Hedlund,  Magnetic resonance microscopy in basic studies of
             brain structure and  function.  New York Academy of
             Sciences.  In press (1996).},
   Year = {1996},
   Key = {fds132738}
}

@article{fds132739,
   Title = {G.A. Johnson, R.D. Black, G.D. Cates, X.J. Chen, B.
             Driehuys, W. Happer,  L.W. Hedlund, H. Middleton, M.D.
             Shattuck, J. Swartz.  Polarization  dynamics of
             hyperpolarized 3He in lung imaging.  in "Proc., SMR 4th
             Annual  Scientific Meeting.  New York, NY, 1996," p.
             19.},
   Year = {1996},
   Key = {fds132739}
}

@article{fds132740,
   Title = {A. LeFurgey, S. Gewalt, N. Wallace, D. Kopf, G.A. Johnson,
             P. Ingram.   Magnetic Resonance Microscoopy of the Adult
             Barnacle.  in "Proc.,  MicroCosmopolitan (14th Australian
             Conference on Electron Microscopy,  1st Meeting,
             International Union of Microbeam Analysis Societies, 9th
              Symposium of the Microscopical Society of Australia).
              Syndey, Australia,  1996," p. 105.},
   Year = {1996},
   Key = {fds132740}
}

@article{fds132741,
   Title = {J.R. MacFall, H.C.Charles, R.D. Black, H. Middleton,
             J.Swartz, B. Saam,   B. Dreihuys, C. Erickson, W. Happer,
             G. Cates, G.A. Johnson, C.E. Ravin.   Human lung air
             spaces: potential for MR imaging with hyperpolarized He-3.
               Radiology 200, 553-558. (1996).},
   Year = {1996},
   Key = {fds132741}
}

@article{fds132742,
   Title = {J.R. MacFall, H.C.Charles, R.D. Black, H. Middleton,
             J.Swartz, B. Saam,   W. Happer, G. Cates, G.A. Johnson,
             C.E. Ravin. MR imaging of lung air  spaces with
             hyperpolarized 3He.  in "Proc., SMR 4th Annual Scientific
              Meeting.  New York, NY, 1996," p. 21.},
   Year = {1996},
   Key = {fds132742}
}

@article{fds132743,
   Title = {H. Qiu, L.W. Hedlund, H. Benveniste, S.L. Gewalt, G.A.
             Johnson.   Evaluation of a glycine antagonist in rat focal
             cerebral ischemia by  diffusion-weighted MR microscopy.
              in "Proc., SMR 4th Annual Scientific  Meeting.  New
             York, NY, 1996," p. 505.},
   Year = {1996},
   Key = {fds132743}
}

@article{fds132744,
   Title = {C. Zimmer,  S.C.J. Wright, R.T. Engelhardt, G.A. Johnson,
             X.O. Breakefield,  R. Weissleder.  Tumor cell endocytosi
             (TCE) imaging facilitates delineation  of the glioma-brain
             interface. (1996).},
   Year = {1996},
   Key = {fds132744}
}

@booklet{Teixeira96,
   Author = {M. G. Teixeira and K. J. Austin and D. J. Perry and V. D.
             Dooley and G. A. Johnson and T. R. Hansen},
   Title = {Granulocyte chemotactic protein-2 (GCP-2) is a
             pregnancy-associated uterine chemokine.},
   Journal = {Biology Of Reproduction},
   Volume = {54},
   Pages = {190 -- 190},
   Year = {1996},
   Key = {Teixeira96}
}

@booklet{Schuster96,
   Author = {H. G. Schuster and E. Niebur and E. R. Hunt and G. A.
             Johnson and M. Locher},
   Title = {Parametric feedback resonance in chaotic
             systems},
   Journal = {Physical Review Letters},
   Volume = {76},
   Number = {3},
   Pages = {400 -- 403},
   Year = {1996},
   Month = {January},
   Key = {Schuster96}
}

@booklet{Delnomdedieu96,
   Author = {Delnomdedieu, M and Hedlund, LW and Johnson, GA and Maronpot,
             RR},
   Title = {Magnetic resonance microscopy--a new tool for the
             toxicologic pathologist.},
   Journal = {Toxicologic Pathology (Sage)},
   Volume = {24},
   Number = {1},
   Pages = {36-44},
   Year = {1996},
   Month = {January},
   ISSN = {0192-6233},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8839279},
   Abstract = {Parallel to its many applications in medical imaging,
             magnetic resonance (MR) microscopy is a potentially powerful
             tool in toxicologic pathology. Because of the intrinsic
             qualities of MR microscopy (noninvasiveness,
             3-dimensionality, and slicing in any chosen plane), the
             scientist has a new means by which to investigate different
             types of lesions based on differential contrast. By choosing
             appropriate proton stains to probe the state of the water in
             tissues, organ structure and vasculature can be seen and
             progressive lesion development can be followed in a given
             animal. This paper discusses toxicologic pathology
             applications for MR microscopy and compares MR microscopy
             with conventional histopathology using a time-course study
             of bromobenzene-induced hepatotoxicity in rats. Hematoxylin
             and eosin (H&E)-stained histological sections are compared
             with MR microscopy images from fixed tissue blocks to
             demonstrate one of the applications of MR microscopy to
             toxicologic pathology. The results indicate that MR
             microscopy is as sensitive as conventional H&E staining in
             detecting bromobenzene-induced hepatic lesions.},
   Doi = {10.1177/019262339602400106},
   Key = {Delnomdedieu96}
}

@article{fds132913,
   Author = {HG Schuster and E Niebur and ER Hunt and GA Johnson and M
             Löcher},
   Title = {Parametric feedback resonance in chaotic
             systems.},
   Journal = {Physical review letters},
   Volume = {76},
   Number = {3},
   Pages = {400-403},
   Year = {1996},
   Month = {January},
   ISSN = {1079-7114},
   Language = {ENG},
   Key = {fds132913}
}

@booklet{Johnson96d,
   Author = {G. A. Johnson and G. A. Livesay and S. L. Y. Woo and K. R.
             Rajagopal},
   Title = {A single integral finite strain viscoelastic model of
             ligaments and tendons},
   Journal = {Journal Of Biomechanical Engineering-transactions Of The
             Asme},
   Volume = {118},
   Number = {2},
   Pages = {221 -- 226},
   Year = {1996},
   Month = {May},
   Key = {Johnson96d}
}

@booklet{Shengunther96,
   Author = {J. Shengunther and J. L. Walker and G. A. Johnson and R. S.
             Mannel},
   Title = {Hepatic venoocclusive disease as a complication of whole
             abdominopelvic irradiation and treatment with the
             transjugular intrahepatic portosystemic shunt: Case report
             and literature review},
   Journal = {Gynecologic Oncology},
   Volume = {61},
   Number = {2},
   Pages = {282 -- 286},
   Year = {1996},
   Month = {May},
   Key = {Shengunther96}
}

@booklet{Engelhardt96,
   Author = {Engelhardt, RT and Johnson, GA},
   Title = {T1 rho relaxation and its application to MR
             histology.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {35},
   Number = {5},
   Pages = {781-786},
   Year = {1996},
   Month = {May},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8722830},
   Abstract = {The application of T1 rho an an alternative contrast
             parameter in high-field magnetic resonance histology (MRH)
             has been investigated. Spectroscopic measurements of T1 rho
             were performed on 5.75% agar and 1.0 mM MnCI2 phantoms at
             9.4 T to validate the accuracy of the imaging measurements.
             Image studies were performed at 2.0 and 9.4 T on
             perfusion-fixed 17.5-day-old mouse embryos. T1, T2, and T1
             rho relaxation times were calculated for the phantoms and
             muscle, diencephalon, and liver tissues. The 5.75% agar
             phantom and all tissues showed T1 rho dispersion with B1L,
             whereas the 1.0 mM MnCI2 phantom showed no significant B1L
             dependence. T1 rho dispersion with B(O) was observed arising
             from the effects of diffusion through susceptibility-induced
             gradients. T1 rho shows promise as a contrast parameter in
             high-field MRH because it is capable of producing T2-like
             contrast without the susceptibility artifacts associated
             with T2-weighted images.},
   Key = {Engelhardt96}
}

@article{fds132833,
   Author = {RT Engelhardt and GA Johnson},
   Title = {T1 rho relaxation and its application to MR
             histology.},
   Journal = {Magnetic resonance in medicine : official journal of the
             Society of Magnetic Resonance in Medicine / Society of
             Magnetic Resonance in Medicine, UNITED STATES},
   Volume = {35},
   Number = {5},
   Pages = {781-6},
   Year = {1996},
   Month = {May},
   ISSN = {0740-3194},
   Keywords = {Animals • Embryo • Female • Histological
             Techniques • Image Enhancement • Magnetic
             Resonance Imaging • Magnetic Resonance Spectroscopy
             • Mice • Microscopy • Phantoms, Imaging
             • anatomy & histology • diagnostic use •
             instrumentation • methods • methods*},
   Abstract = {The application of T1 rho an an alternative contrast
             parameter in high-field magnetic resonance histology (MRH)
             has been investigated. Spectroscopic measurements of T1 rho
             were performed on 5.75% agar and 1.0 mM MnCI2 phantoms at
             9.4 T to validate the accuracy of the imaging measurements.
             Image studies were performed at 2.0 and 9.4 T on
             perfusion-fixed 17.5-day-old mouse embryos. T1, T2, and T1
             rho relaxation times were calculated for the phantoms and
             muscle, diencephalon, and liver tissues. The 5.75% agar
             phantom and all tissues showed T1 rho dispersion with B1L,
             whereas the 1.0 mM MnCI2 phantom showed no significant B1L
             dependence. T1 rho dispersion with B(O) was observed arising
             from the effects of diffusion through susceptibility-induced
             gradients. T1 rho shows promise as a contrast parameter in
             high-field MRH because it is capable of producing T2-like
             contrast without the susceptibility artifacts associated
             with T2-weighted images.},
   Key = {fds132833}
}

@article{fds174112,
   Author = {GA Johnson and GA Livesay and SL Woo and KR Rajagopal},
   Title = {A single integral finite strain viscoelastic model of
             ligaments and tendons.},
   Journal = {Journal of biomechanical engineering},
   Volume = {118},
   Number = {2},
   Pages = {221-6},
   Year = {1996},
   Month = {May},
   ISSN = {0148-0731},
   Keywords = {Adult • Aged • Aged, 80 and over • Animals
             • Dogs • Elasticity • Humans • Ligaments
             • Middle Aged • Models, Biological* •
             Nonlinear Dynamics • Patella • Stress, Mechanical
             • Tendons • Viscosity • physiology •
             physiology*},
   Abstract = {A general continuum model for the nonlinear viscoelastic
             behavior of soft biological tissues was formulated. This
             single integral finite strain (SIFS) model describes finite
             deformation of a nonlinearly viscoelastic material within
             the context of a three-dimensional model. The specific form
             describing uniaxial extension was obtained, and the idea of
             conversion from one material to another (at a microscopic
             level) was then introduced to model the nonlinear behavior
             of ligaments and tendons. Conversion allowed different
             constitutive equations to be used for describing a single
             ligament or tendon at different strain levels. The model was
             applied to data from uniaxial extension of younger and older
             human patellar tendons and canine medial collateral
             ligaments. Model parameters were determined from
             curve-fitting stress-strain and stress-relaxation data and
             used to predict the time-dependent stress generated by
             cyclic extensions.},
   Language = {eng},
   Key = {fds174112}
}

@article{fds174120,
   Author = {J Shen-Gunther and JL Walker and GA Johnson and RS
             Mannel},
   Title = {Hepatic venoocclusive disease as a complication of whole
             abdominopelvic irradiation and treatment with the
             transjuglar intrahepatic portosystemic shunt: case report
             and literature review.},
   Journal = {Gynecologic oncology},
   Volume = {61},
   Number = {2},
   Pages = {282-6},
   Year = {1996},
   Month = {May},
   ISSN = {0090-8258},
   Keywords = {Abdomen • Adenocarcinoma • Ascites •
             Endometrial Neoplasms • Female • Hepatic
             Veno-Occlusive Disease • Humans • Jugular Veins
             • Middle Aged • Pelvis • Portasystemic Shunt,
             Surgical* • Radiotherapy • Randomized Controlled
             Trials as Topic • Stents • adverse effects* •
             complications • etiology* • instrumentation •
             radiotherapy • surgery},
   Abstract = {We report the novel use of the transjugular intrahepatic
             portosystemic shunt (TIPS) procedure for the treatment of
             intractable ascites due to hepatic venooclusive disease as a
             result of whole abdominopelvic radiotherapy. A patient with
             Stage III endometrioid carcinoma of the endometrium treated
             with postoperative whole abdominopelvic irradiation
             developed intractable ascites. Multiple paracenteses and
             computerized tomography were negative for recurrent
             carcinoma. Liver biopsy demonstrated hepatic venoocclusive
             disease, a rare complication of therapeutic radiation
             involving the liver. Successful relief of ascites and its
             adverse symptomology were achieved with the transjugular
             intrahepatic portosystemic shunt. Relevant literature
             regarding the pathogenesis, prognosis, and treatment of
             radiotherapy-related hepatic venoocclusive disease are
             reviewed.},
   Language = {eng},
   Key = {fds174120}
}

@booklet{Hall96,
   Author = {Hall, WL and Benveniste, H and Hedlund, LW and Johnson,
             GA},
   Title = {A new in vivo method for quantitative analysis of stroke
             lesions using diffusion-weighted magnetic resonance
             microscopy},
   Journal = {NeuroImage},
   Volume = {3},
   Number = {3},
   Pages = {158-166},
   Year = {1996},
   Month = {June},
   ISSN = {1053-8119},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1996UQ76900002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1006/nimg.1996.0017},
   Key = {Hall96}
}

@booklet{Black96,
   Author = {Black, RD and Middleton, HL and Cates, GD and Cofer, GP and Driehuys, B and Happer, W and Hedlund, LW and Johnson, GA and Shattuck, MD and Swartz,
             JC},
   Title = {In vivo He-3 MR images of guinea pig lungs.},
   Journal = {Radiology},
   Volume = {199},
   Number = {3},
   Pages = {867-870},
   Year = {1996},
   Month = {June},
   ISSN = {0033-8419},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8638019},
   Abstract = {The authors imaged the lungs of live guinea pigs with
             hyperpolarized (HP) helium-3 as a magnetic resonance (MR)
             signal source. HP He-3 gas produced through spin exchange
             with rubidium metal vapor was delivered through an
             MR-compatible, small-animal ventilator. Two- and
             three-dimensional lung images acquired with
             ventilation-gated, radial k-space sampling showed complete
             ventilation of both lungs. All images were of high quality,
             demonstrating that HP He-3 allows high-signal-intensity MR
             imaging in living systems.},
   Doi = {10.1148/radiology.199.3.8638019},
   Key = {Black96}
}

@article{fds132806,
   Author = {RD Black and HL Middleton and GD Cates and GP Cofer and B Driehuys and W
             Happer, LW Hedlund and GA Johnson, MD Shattuck and JC
             Swartz},
   Title = {In vivo He-3 MR images of guinea pig lungs.},
   Journal = {Radiology, UNITED STATES},
   Volume = {199},
   Number = {3},
   Pages = {867-70},
   Year = {1996},
   Month = {June},
   ISSN = {0033-8419},
   Keywords = {Animals • Guinea Pigs • Helium • Lung •
             Magnetic Resonance Imaging • Male • Radioisotopes
             • anatomy & histology* • instrumentation •
             methods* • statistics & numerical data},
   Abstract = {The authors imaged the lungs of live guinea pigs with
             hyperpolarized (HP) helium-3 as a magnetic resonance (MR)
             signal source. HP He-3 gas produced through spin exchange
             with rubidium metal vapor was delivered through an
             MR-compatible, small-animal ventilator. Two- and
             three-dimensional lung images acquired with
             ventilation-gated, radial k-space sampling showed complete
             ventilation of both lungs. All images were of high quality,
             demonstrating that HP He-3 allows high-signal-intensity MR
             imaging in living systems.},
   Key = {fds132806}
}

@article{fds132832,
   Author = {WL Hall and H Benveniste and LW Hedlund and GA Johnson},
   Title = {A new in vivo method for quantitative analysis of stroke
             lesions using diffusion-weighted magnetic resonance
             microscopy.},
   Journal = {NeuroImage, UNITED STATES},
   Volume = {3},
   Number = {3 Pt 1},
   Pages = {158-66},
   Year = {1996},
   Month = {June},
   ISSN = {1053-8119},
   Keywords = {Animals • Brain Ischemia • Disease Models, Animal
             • Female • Magnetic Resonance Imaging* •
             Microscopy • Models, Neurological • Rats •
             Rats, Inbred F344 • Stroke Volume • diagnosis
             • methods* • pathology* •
             physiopathology},
   Abstract = {Using three-dimensional diffusion-weighted MR microscopy and
             a rat model of focal cerebral ischemia, we evaluated the
             statistical characteristics of two parameters: absolute
             stroke volumes and change in stroke volumes over 6 h of
             middle cerebral artery (MCA) occlusion. In all rats, the
             absolute stroke volumes increased linearly over the 6-h MCA
             occlusion time period. On average, stroke volume growth rate
             was 2.1 +/- 0.5%/h. Sample size power analysis of our data
             demonstrated that to demonstrate a 10% reduction of the 6-h
             volumes, sample size per group would require 29 animals
             (these calculations are based on alpha = 0.05, beta = 0.20
             using normal approximation). A similar 30% reduction of
             stroke volume at 6 h poststroke (from approximately equal to
             200 to 140 mm3) would, in our "slope model," translate into
             a reduction of stroke growth rate from the normal + 11.25
             mm3/h (150 to 200 mm3 over 4 h) to 7 mm3/h (150 to 178 mm3
             over 4 h); power analysis in this case demonstrated that
             sample size is reduced to 15 animals per group (these
             calculations are based on alpha = 0.05, beta = 0.20 using
             normal approximation). We conclude that from a statistical
             standpoint our study demonstrates that stroke growth rate
             might be a more suitable parameter for evaluating the effect
             of treatment in both clinical and experimental stroke
             trials.},
   Key = {fds132832}
}

@booklet{Macfall96,
   Author = {MacFall, JR and Charles, HC and Black, RD and Middleton, H and Swartz,
             JC and Saam, B and Driehuys, B and Erickson, C and Happer, W and Cates, GD and Johnson, GA and Ravin, CE},
   Title = {Human lung air spaces: potential for MR imaging with
             hyperpolarized He-3.},
   Journal = {Radiology},
   Volume = {200},
   Number = {2},
   Pages = {553-558},
   Year = {1996},
   Month = {August},
   ISSN = {0033-8419},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8685356},
   Abstract = {Two healthy volunteers who had inhaled approximately 0.75 L
             of laser-polarized helium-3 gas underwent magnetic resonance
             imaging at 1.5 T with fast gradient-echo pulse sequences and
             small flip angles ( < 10 degrees). Thick-section (20 mm)
             coronal images, time-course data (30 images collected every
             1.8 seconds), and thin-section (6 mm) images were acquired.
             Subjects were able to breathe the gas (12% polarization)
             without difficulty. Thick-section images were of good
             quality and had a signal-to-noise ratio (S/N) of 32:1 near
             the surface coil and 16:1 farther away. The time images
             showed regional differences, which indicated potential value
             for quantitation. High-resolution images showed greater
             detail and a S/N of approximately 6:1.},
   Doi = {10.1148/radiology.200.2.8685356},
   Key = {Macfall96}
}

@article{fds132793,
   Author = {JR MacFall and HC Charles and RD Black and H Middleton and JC Swartz and B
             Saam, B Driehuys and C Erickson and W Happer and GD Cates and GA
             Johnson, CE Ravin},
   Title = {Human lung air spaces: potential for MR imaging with
             hyperpolarized He-3.},
   Journal = {Radiology, UNITED STATES},
   Volume = {200},
   Number = {2},
   Pages = {553-8},
   Year = {1996},
   Month = {August},
   ISSN = {0033-8419},
   Keywords = {Adult • Helium • Humans • Image Enhancement
             • Isotopes • Lung • Magnetic Resonance
             Imaging • Male • Middle Aged • anatomy &
             histology* • diagnostic use* • instrumentation
             • methods • methods*},
   Abstract = {Two healthy volunteers who had inhaled approximately 0.75 L
             of laser-polarized helium-3 gas underwent magnetic resonance
             imaging at 1.5 T with fast gradient-echo pulse sequences and
             small flip angles ( < 10 degrees). Thick-section (20 mm)
             coronal images, time-course data (30 images collected every
             1.8 seconds), and thin-section (6 mm) images were acquired.
             Subjects were able to breathe the gas (12% polarization)
             without difficulty. Thick-section images were of good
             quality and had a signal-to-noise ratio (S/N) of 32:1 near
             the surface coil and 16:1 farther away. The time images
             showed regional differences, which indicated potential value
             for quantitation. High-resolution images showed greater
             detail and a S/N of approximately 6:1.},
   Key = {fds132793}
}

@booklet{Johnson96a,
   Author = {G. A. Johnson and M. Locher and E. R. Hunt},
   Title = {Stable states and kink dynamics in a system of coupled diode
             resonators},
   Journal = {Physica D},
   Volume = {96},
   Number = {1-4},
   Pages = {367 -- 374},
   Year = {1996},
   Month = {September},
   Key = {Johnson96a}
}

@booklet{Smith96,
   Author = {Smith, BR and Linney, E and Huff, DS and Johnson,
             GA},
   Title = {Magnetic resonance microscopy of embryos.},
   Journal = {Computerized Medical Imaging and Graphics},
   Volume = {20},
   Number = {6},
   Pages = {483-490},
   Year = {1996},
   Month = {November},
   ISSN = {0895-6111},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/9007215},
   Abstract = {We demonstrate that magnetic resonance (MR) microscopy
             provides a mechanism to investigate normal and abnormal
             developmental anatomy in a non-destructive and
             distortion-free manner. Techniques for the fixation,
             embedding, perfusion and image acquisition of embryos
             between 3 and 30 mm crown rump length are described. We
             describe the perfusion of a contrast agent to enhance images
             of the developing embryonic vasculature. Data are acquired
             as three-dimensional isotropic arrays which permit images to
             be reformatted retrospectively in any plane. The data are
             available for archiving, distributing and for
             post-acquisition manipulations. MR microscopy is a fast
             technique for producing three-dimensional reconstructions
             and is free from registration and sectioning
             artifacts.},
   Key = {Smith96}
}

@booklet{Chotas96,
   Author = {Chotas, HG and Floyd, CE and Johnson, GA and Ravin,
             CE},
   Title = {Quality control phantom for digital chest
             radiography},
   Journal = {Radiology},
   Volume = {201},
   Pages = {685-685},
   Year = {1996},
   Month = {November},
   ISSN = {0033-8419},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1996VP84300732&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Chotas96}
}

@booklet{Johnson96,
   Author = {Johnson, GA and Hedlund, LW},
   Title = {Functional imaging of the lung.},
   Journal = {Nature Medicine},
   Volume = {2},
   Number = {11},
   Pages = {1192},
   Year = {1996},
   Month = {November},
   ISSN = {1078-8956},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8898741},
   Key = {Johnson96}
}

@article{fds132766,
   Author = {GA Johnson and LW Hedlund},
   Title = {Functional imaging of the lung.},
   Journal = {Nature medicine, UNITED STATES},
   Volume = {2},
   Number = {11},
   Pages = {1192},
   Year = {1996},
   Month = {November},
   ISSN = {1078-8956},
   Keywords = {Lung • Magnetic Resonance Imaging* •
             physiology*},
   Key = {fds132766}
}

@booklet{Locher96,
   Author = {M. Locher and G. A. Johnson and E. R. Hunt},
   Title = {Spatiotemporal stochastic resonance in a system of coupled
             diode resonators},
   Journal = {Physical Review Letters},
   Volume = {77},
   Number = {23},
   Pages = {4698 -- 4701},
   Year = {1996},
   Month = {December},
   Key = {Locher96}
}

@article{fds132911,
   Author = {M Löcher and GA Johnson and ER Hunt},
   Title = {Spatiotemporal Stochastic Resonance in a System of Coupled
             Diode Resonators.},
   Journal = {Physical review letters},
   Volume = {77},
   Number = {23},
   Pages = {4698-4701},
   Year = {1996},
   Month = {December},
   ISSN = {1079-7114},
   Language = {ENG},
   Key = {fds132911}
}

@booklet{Cardina97,
   Author = {J. Cardina and G. A. Johnson and D. H. Sparrow},
   Title = {The nature and consequence of weed spatial
             distribution},
   Journal = {Weed Science},
   Volume = {45},
   Number = {3},
   Pages = {364 -- 373},
   Year = {1997},
   Key = {Cardina97}
}

@booklet{Gerhards97,
   Author = {R. Gerhards and D. Y. Wysepester and D. Mortensen and G. A.
             Johnson},
   Title = {Characterizing spatial stability of weed populations using
             interpolated maps},
   Journal = {Weed Science},
   Volume = {45},
   Number = {1},
   Pages = {108 -- 119},
   Year = {1997},
   Key = {Gerhards97}
}

@booklet{Qiu97a,
   Author = {H. Qiu and L. W. Hedlund and S. L. Gewalt and H. Benveniste and T. M. Bare and G. A. Johnson},
   Title = {Progression of a focal ischemic lesion in rat brain during
             treatment with a novel glycine/NMDA antagonist: An in vivo
             three-dimensional diffusion-weighted MR microscopy
             study},
   Journal = {Jmri-journal Of Magnetic Resonance Imaging},
   Volume = {7},
   Number = {4},
   Pages = {739 -- 744},
   Year = {1997},
   Key = {Qiu97a}
}

@article{fds268762,
   Author = {Bcnveniste, H and Hüttemeier, PC and Qiu, H and Steele, S and Hedlund,
             LW and Johnson, GA},
   Title = {Magnetic resonance imaging of continuous spinal anesthesia
             with hyperbaric lidocaine: Root or white matter
             lesion?},
   Journal = {Regional anesthesia},
   Volume = {22},
   Number = {2 SUPPL.},
   Pages = {15-},
   Year = {1997},
   ISSN = {0146-521X},
   Abstract = {Introduction: Persistent neurologic deficits in patients
             after continuous spinal anesthesia with hyperbaric lidocaine
             may have been erroneously characterized as a cauda equina
             syndrome (1,2). First, clinical reports of symptoms rarely
             include pain (typical for cauda equina lesions) but most
             often consist of saddle anesthesia, paraplegia and sphincter
             dysfunction (typical for conus medullaris lesions).
             Secondly, spinal cord damage in dogs after intrathecal
             procaine (3) or lidocaine (4) is confined only to the myelin
             sheath beneath the pia mater and not nerve roots. In this
             study we use diffusion-weighted magnetic resonance imaging
             (DWI) to further characterize hyperbaric lidocaine-induced
             spinal cord damage. DWI measures diffusion of free protons
             and is a very sensitive detector of white or gray matter
             injury (5). Normal spinal cord gray and white matter as well
             as nerve roots are clearly visualized by DWI because the
             proton diffusion coefficient (DC) - the critical parameter
             measured with DWI - within these tissues differs. The effect
             of hyperbaric 5% lidocaine on the spinal cord diffusion
             coefficient will be compared with those found in ischémie
             conditions. Methods: The study was approved by the Duke
             University Animal Care Institutional Committee. Nine female
             adult Fisher rats (weighing 150-190g) were anesthetized with
             isoflurane, intubated and mechanically ventilated. Catheters
             were inserted into the right external jugular vein and
             carotid artery. Heart rate, arterial blood pressure and body
             temperature was monitored continuously. Diffusion-weighted
             MR images (DWI) were acquired at the level of C6 in five
             rats before and after ischemia induced by cardiac arrest. In
             another four rats catheters were first placed intrathecally
             via the atlanto-occipital membrane. Subsequently, DWI's were
             acquired at the level of C6 before and during 3 hr
             continuous intrathecal perfusion with 5% hyperbaric
             lidocaine. Hemodynamic stability during lidocaine
             administration was maintained with i.v. hydration, atropine
             and ephedrine as needed. All imaging was done on a 7 T
             magnet using a standard spin echo diffusion pulse sequence
             (5). Results: Ischemia reduced the diffusion coefficient
             (DC) of white matter by 25%, gray matter by 45% and nerve
             roots/dorsal root ganglia by 35%. Figure 1 shows that one
             hour of continuous intrathecal administration of 5%
             hyperbaric lidocaine reduces the DC of white matter by 15%
             and that the changes are not as profound as those found
             during ischemia (results are presented as mean ± SD).
             Figure 2 shows that in contrast to white matter, DCs of
             adjacent nerve roots are unaffected by 5 % hyperbaric
             lidocaine. Discussion: The present study has led to the
             following conclusion: (1) diffusion-weighted imaging of
             spinal cord in rats with indwelling intrathecal catheters is
             possible in vivo, (2) the diffusion coefficient of white
             matter is reduced by 15% after 1 hr of 5% hyperbaric
             lidocaine indicating onset of cytotoxic edema, (3) the
             lidocaine-induced changes in the white matter DC do not
             reach ischémie levels, (4) adjacent gray matter as well as
             nerve roots are unaffected. Ongoing work will provide
             information as to the exact pathophysiological sequence of
             events which lead to irreversible spinal cord damage during
             continuous spinal anesthesia with high dose hyperbaric 5%
             lidocaine. It is our goal that this research will be
             applicable to local anesthesia toxicity studies and useful
             as a future neurotoxicity screening tool for new intralhecal
             drugs designed for both anesthesia and analgesia.},
   Key = {fds268762}
}

@booklet{Hurlston97,
   Author = {Hurlston, SE and Cofer, GP and Johnson, GA},
   Title = {Optimized radiofrequency coils for increased signal-to-noise
             ratio in magnetic resonance microscopy},
   Journal = {International Journal of Imaging Systems and
             Technology},
   Volume = {8},
   Number = {3},
   Pages = {277-284},
   Year = {1997},
   Abstract = {The signal-to-noise ratio (SNR) is a major obstacle to
             achieving increased resolution in magnetic resonance
             microscopy (MRM). The SNR considerations for MRM are
             presented, with particular attention to the role of
             judicious receiver coil design in maximizing sensitivity and
             limiting noise contributions both from the sample and the
             coil. We present a number of different coil configurations
             that have been optimized for particular applications of MRM
             in the biological sciences. An overview of the literature
             regarding derivations of the SNR for birdcage-configuration
             volume coils, inductively coupled surface coils, and
             surgically implanted coils is presented in a unified
             fashion. Microscopy coils designed to reduce the total
             volume of excitation, thus coupling more closely to a given
             region of interest, are discussed. The volume coil is
             presented in terms of its application to lung imaging in
             small animals at 2 T and imaging of stroke at 7 T. The
             performance of traditional surface coils is demonstrated by
             application to spinal cord imaging in the rat. Finally,
             implanted coils are examined, as used in studies of the
             carotid arteries. © 1997 John Wiley &amp; Sons,
             Inc.},
   Key = {Hurlston97}
}

@booklet{Zimmer97,
   Author = {Zimmer, C and Jr, SCW and Engelhardt, RT and Johnson, GA and Kramm, C and Breakefield, XO and Weissleder, R},
   Title = {Tumor cell endocytosis imaging facilitates delineation of
             the glioma-brain interface},
   Journal = {Experimental Neurology},
   Volume = {143},
   Number = {1},
   Pages = {61-69},
   Year = {1997},
   ISSN = {0014-4886},
   url = {http://dx.doi.org/10.1006/exnr.1996.6350},
   Abstract = {We describe a method for measuring tumor cell endocytosis in
             vivo and provide the anatomic correlate of this tumor cell
             function using a superparamagnetic and histologically
             detectable marker for cell uptake (MION). Rats (n = 22) were
             intrahemispherically implanted with a thymidine kinase
             (TK)-positive 9L gliosarcoma cell line, where TK served as
             the tumor marker. Twenty-four hours after intravenous
             injection of 10 mg Fe/kg of MION, rat brains were removed
             and underwent MR imaging ex vivo at near-microscopic
             resolution (isotropic voxel size of 86 μm, 9.4 T) prior to
             histologic processing. The imaging probe accumulated within
             tumor cells adjacent to the hyperpermeable tumor-brain
             interface including microscopic deposits and along
             finger-like invasions of the tumor into brain, facilitating
             the demarcation of the true histologic tumor border in three
             dimensions by MR microscopy. The method has potential
             research and clinical implications for delineating the
             tumor-brain interface prior to therapy and/or for providing
             a rational basis for imaging nanocolloid drug delivery to
             solid tumors.},
   Doi = {10.1006/exnr.1996.6350},
   Key = {Zimmer97}
}

@booklet{Shattuck97a,
   Author = {Shattuck, MD and Behringer, RP and Johnson, GA and Georgiadis,
             JG},
   Title = {Convection and flow in porous media. Part 1. Visualization
             by magnetic resonance imaging},
   Journal = {Journal of Fluid Mechanics},
   Volume = {332},
   Pages = {215-245},
   Year = {1997},
   Abstract = {We describe an experimental study of porous media convection
             (PMC) from onset to 8Rac. The goal of this work is to
             provide non-invasive imaging and high-precision heat
             transport measurements to test theories of convection in
             PMC. We obtain velocity information and visualize the
             convection patterns using magnetic resonance imaging (MRI).
             We study both ordered and disordered packings of
             mono-disperse spheres of diameter d = 3.204 ± 0.029 mm, in
             circular, rectangular, and hexagonal planforms. In general,
             the structure of the medium plays a role which is not
             predicted by theories which assume a homogeneous system.
             Disordered media are prepared by pouring mono-disperse
             spheres into the container. Large ordered regions of close
             packing for the spheres, with grain boundaries and isolated
             defects, characterize these media. The defects and grain
             boundaries play an important role in pattern formation in
             disordered media. Any deviation from close packing produces
             a region of larger porosity, hence locally larger
             permeability. The result is spatial variations in the
             Rayleigh number, Ra. We define the critical Ra, Rac, as the
             Rayleigh number at the onset of convection in the ordered
             regions. We find that stable localized convective regions
             exist around grain boundaries and defects at Ra &lt; Rac.
             These remain as pinning sites for the convection patterns in
             the ordered regions as Ra increases above Rac up to 5Rac,
             the highest Ra studied in the disordered media. In ordered
             media, spheres are packed such that the only deviations from
             close packing occur within a thin (&lt;d) region near the
             vertical walls. Stable localized convection begins at 0.5Rac
             in the wall regions but appears to play only a weak role in
             the pattern formation of the interior regions (bulk), since
             different stable patterns are observed in the bulk at the
             same Ra after each cycling of Ra below Rac, even for similar
             patterns of small rolls in the wall regions. The experiments
             provide a test of the following predictions for PMC: (i)
             that straight parallel rolls should be linearly stable for
             Rac &lt; Ra &lt; 5Rac; (ii) that at onset, the rolls should
             have a dimensionless wavevector qc = π; (iii) that at the
             upper end of this range rolls should lose stability to
             cross-rolls; (iv) that the initial slope of the Nusselt
             curve should be 2; (v) that there should be a rapid decay of
             vertical vorticity - hence no complex flows, such as those
             which occur for Rayleigh-Bénard convection (RBC) within the
             nominal regime of stable parallel rolls. These predictions
             are in partial agreement with our findings for the bulk
             convection in the ordered media. We observe roll-like
             structures which relax rapidly to stable patterns between
             Rac and 5Rac. However we find a wavenumber which is 0.7π
             compared to π derived from linear stability theory. We find
             an asymmetry between the size of the upflowing regions and
             downflowing regions as Ra grows above Rac. The ratio of the
             volume of the upflowing to the volume of the downflowing
             regions decreases as Ra increases and leads to a novel
             time-dependent state, which does not consist of cross-rolls.
             This time-dependent state begins at 6Rac and is observed up
             to 8Rac, the largest Ra which we studied. It seems likely
             that the occurrence of this state is linked to departures
             from the Boussinesq approximation at higher Ra. We also find
             that the slope of the Nusselt curve is 0.7, which does not
             agree with the predicted value of 2.},
   Key = {Shattuck97a}
}

@booklet{Shengunther97,
   Author = {J. Shengunther and R. S. Mannel and J. L. Walker and G. A.
             Johnson},
   Title = {Construction of the ileocolonic continent urinary reservoir:
             Operative technique at the University of
             Oklahoma},
   Journal = {Journal Of Gynecologic Surgery},
   Volume = {13},
   Number = {2},
   Pages = {83 -- 88},
   Year = {1997},
   Key = {Shengunther97}
}

@booklet{Johnson97,
   Author = {G. A. Johnson and K. J. Austin and E. A. Vankirk and T. R.
             Hansen},
   Title = {Pregnancy and interferon-tau induce conjugation of bovine
             ubiquitin cross-reactive protein to cytosolic uterine
             proteins.},
   Journal = {Biology Of Reproduction},
   Volume = {56},
   Pages = {160 -- 160},
   Year = {1997},
   Key = {Johnson97}
}

@booklet{Staggs97,
   Author = {K. L. Staggs and K. J. Austin and G. A. Johnson and C. T.
             Talbott and T. R. Hansen},
   Title = {Interferon-tau may elicit specific responses in the
             endometrium through signal transduction pathways other than
             the Jak/Stat system.},
   Journal = {Biology Of Reproduction},
   Volume = {56},
   Pages = {159 -- 159},
   Year = {1997},
   Key = {Staggs97}
}

@booklet{Chotas97,
   Author = {Chotas, HG and Floyd, CE and Johnson, GA and Ravin,
             CE},
   Title = {Quality control phantom for digital chest
             radiography.},
   Journal = {Radiology},
   Volume = {202},
   Number = {1},
   Pages = {111-116},
   Year = {1997},
   Month = {January},
   ISSN = {0033-8419},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/8988199},
   Abstract = {PURPOSE: To develop and test a chest phantom for routine
             quality control testing of digital radiography systems.
             MATERIALS AND METHODS: The phantom was constructed from
             sheets of copper, aluminum, and acrylic, which were cut and
             arranged to yield a radiographic projection resembling that
             of a human thorax. Regional test objects allowed
             quantitative assessment of optical density, contrast detail,
             and spatial resolution. Validation tests were performed to
             assess image stability in a stable imaging environment and
             sensitivity to changes in image quality when they occur.
             RESULTS: The phantom yielded consistent pseudoclinical
             images when used in a routine quality control program and
             facilitated detection of simulated problems that were
             induced in imaging system performance. CONCLUSION: The chest
             phantom enables quantitative, full-system testing of digital
             radiography system as they are used clinically for chest
             radiography.},
   Doi = {10.1148/radiology.202.1.8988199},
   Key = {Chotas97}
}

@article{fds132759,
   Author = {C Zimmer and SC Wright Jr and RT Engelhardt and GA Johnson and C Kramm and XO Breakefield and R Weissleder},
   Title = {Tumor cell endocytosis imaging facilitates delineation of
             the glioma-brain interface.},
   Journal = {Experimental neurology},
   Volume = {143},
   Number = {1},
   Pages = {61-9},
   Year = {1997},
   Month = {January},
   ISSN = {0014-4886},
   url = {http://dx.doi.org/10.1006/exnr.1996.6350},
   Keywords = {Animals • Biological Markers • Brain Neoplasms
             • Endocytosis* • Glioma • Image Processing,
             Computer-Assisted • Rats • Tumor Cells, Cultured
             • pathology*},
   Abstract = {We describe a method for measuring tumor cell endocytosis in
             vivo and provide the anatomic correlate of this tumor cell
             function using a superparamagnetic and histologically
             detectable marker for cell uptake (MION). Rats (n = 22) were
             intrahemispherically implanted with a thymidine kinase
             (TK)-positive 9L gliosarcoma cell line, where TK served as
             the tumor marker. Twenty-four hours after intravenous
             injection of 10 mg Fe/kg of MION, rat brains were removed
             and underwent MR imaging ex vivo at near-microscopic
             resolution (isotropic voxel size of 86 microm, 9.4 T) prior
             to histologic processing. The imaging probe accumulated
             within tumor cells adjacent to the hyperpermeable
             tumor-brain interface including microscopic deposits and
             along finger-like invasions of the tumor into brain,
             facilitating the demarcation of the true histologic tumor
             border in three dimensions by MR microscopy. The method has
             potential research and clinical implications for delineating
             the tumor-brain interface prior to therapy and/or for
             providing a rational basis for imaging nanocolloid drug
             delivery to solid tumors.},
   Language = {eng},
   Doi = {10.1006/exnr.1996.6350},
   Key = {fds132759}
}

@article{fds132883,
   Author = {HG Chotas and CE Floyd and GA Johnson and CE Ravin},
   Title = {Quality control phantom for digital chest
             radiography.},
   Journal = {Radiology, UNITED STATES},
   Volume = {202},
   Number = {1},
   Pages = {111-6},
   Year = {1997},
   Month = {January},
   ISSN = {0033-8419},
   Keywords = {Humans • Phantoms, Imaging* • Quality Control
             • Radiographic Image Enhancement • Radiography,
             Thoracic • standards*},
   Abstract = {PURPOSE: To develop and test a chest phantom for routine
             quality control testing of digital radiography systems.
             MATERIALS AND METHODS: The phantom was constructed from
             sheets of copper, aluminum, and acrylic, which were cut and
             arranged to yield a radiographic projection resembling that
             of a human thorax. Regional test objects allowed
             quantitative assessment of optical density, contrast detail,
             and spatial resolution. Validation tests were performed to
             assess image stability in a stable imaging environment and
             sensitivity to changes in image quality when they occur.
             RESULTS: The phantom yielded consistent pseudoclinical
             images when used in a routine quality control program and
             facilitated detection of simulated problems that were
             induced in imaging system performance. CONCLUSION: The chest
             phantom enables quantitative, full-system testing of digital
             radiography system as they are used clinically for chest
             radiography.},
   Key = {fds132883}
}

@booklet{Teixeira97,
   Author = {M. G. Teixeira and K. J. Austin and D. J. Perry and V. D.
             Dooley and G. A. Johnson and B. R. Francis and T. R.
             Hansen},
   Title = {Bovine granulocyte chemotactic protein-2 is secreted by the
             endometrium in response to interferon-tau
             (IFN-tau)},
   Journal = {Endocrine},
   Volume = {6},
   Number = {1},
   Pages = {31 -- 37},
   Year = {1997},
   Month = {February},
   Key = {Teixeira97}
}

@article{fds174211,
   Author = {MG Teixeira and KJ Austin and DJ Perry and VD Dooley and GA Johnson and BR
             Francis, TR Hansen},
   Title = {Bovine granulocyte chemotactic protein-2 is secreted by the
             endometrium in response to interferon-tau
             (IFN-tau).},
   Journal = {Endocrine},
   Volume = {6},
   Number = {1},
   Pages = {31-7},
   Year = {1997},
   Month = {February},
   ISSN = {1355-008X},
   Keywords = {Amino Acid Sequence • Animals • Blotting, Western
             • Cattle • Chemokine CXCL6 • Chemokines
             • Chemokines, CXC* • Chromatography, Ion Exchange
             • Electrophoresis, Polyacrylamide Gel •
             Endometrium • Female • Interferon Type I •
             Molecular Sequence Data • Pregnancy Proteins •
             Sheep • immunology • metabolism*},
   Abstract = {Interferon-tau (IFN-tau) is secreted by the bovine conceptus
             and may regulate synthesis of uterine endometrial cytokines
             to provide an environment that is conductive to embryo
             development and implantation. Interferon-tau stimulates
             secretion of an 8-kDa uterine protein (P8) in the cow. P8
             was purified, digested to yield internal peptides, and
             partially sequenced to determine identity. Two internal
             peptides had 100% (13-mer) and 92% (12-mer) amino acid
             sequence identity with bovine granulocyte chemotactic
             protein-2 (bGCP-2). Bovine GCP-2 is an alpha-chemokine that
             acts primarily as a potent chemoattractant for granulocyte
             cells of the immune system. A peptide was synthesized based
             on a region of bGCP-2 that overlapped with a P8 peptide
             amino acid sequence, coupled to keyhole limpet hemocyanin,
             and used to generate high titer polyclonal antiserum in
             sheep. Western blots revealed that bGCP-2 was not released
             by endometrium from day 14 nonpregnant cows, but was
             released in response to 25 nM IFN-tau (p<0.05). Uterine
             GCP-2 exhibited high affinity to heparin agarose, a
             characteristic shared by all alpha chemokines. This is the
             first report describing presence of GCP-2 in the uterine
             endometrium and regulation by IFN-tau. The regulation of
             bGCP-2 by IFN-tau may have important implications for
             cytokine networking in the uterus during pregnancy. Also,
             the regulation of inflammation and angiogenesis by bGCP-2
             working together with other cytokines may be integral to
             establishing early pregnancy and implantation in the
             cow.},
   Language = {eng},
   Key = {fds174211}
}

@article{fds204273,
   Author = {M Glaucia Teixeira and KJ Austin and DJ Perry and VD Dooley and GA
             Johnson, BR Francis and TR Hansen},
   Title = {Bovine granulocyte chemotactic protein-2 is secreted by the
             endometrium in response to interferon-tau
             (IFN-τ).},
   Journal = {Endocrine},
   Volume = {6},
   Number = {1},
   Pages = {31-7},
   Year = {1997},
   Month = {February},
   ISSN = {1355-008X},
   url = {http://dx.doi.org/10.1007/BF02738799},
   Abstract = {Interferon-tau (IFN-τ) is secreted by the bovine conceptus
             and may regulate synthesis of uterine endometrial cytokines
             to provide an environment that is conducive to embryo
             development and implantation. Interferon-τ stimulates
             secretion of an 8-kDa uterine protein (P8) in the cow. P8
             was purified, digested to yield internal peptides, and
             partially sequenced to determine identity. Two internal
             peptides had 100% (13-mer) and 92% (12-mer) amino acid
             sequence identity with bovine granulocyte chemotactic
             protein-2 (bGCP-2). Bovine GCP-2 is an α-chemokine that
             acts primarily as a potent chemoattractant for granulocyte
             cells of the immune system. A peptide was synthesized based
             on a region of bGCP-2 that overlapped with a P8 peptide
             amino acid sequence, coupled to keyhole limpet hemocyanin,
             and used to generate high titer polyclonal antiserum in
             sheep. Western blots revealed that bGCP-2 was not released
             by endometrium from day 14 nonpregnant cows, but was
             released in response to 25 nM IFN-τ (p<0.05). Uterine GCP-2
             exhibited high affinity to heparin agarose, a characteristic
             shared by all α chemokines. This is the first report
             describing presence of GCP-2 in the uterine endometrium and
             regulation by IFN-τ. The regulation of bGCP-2 by IFN-τ may
             have important implications for cytokine networking in the
             uterus during pregnancy. Also, the regulation of
             inflammation and angiogenesis by bGCP-2 working together
             with other cytokines may be integral to establishing early
             pregnancy and implantation in the cow.},
   Language = {eng},
   Doi = {10.1007/BF02738799},
   Key = {fds204273}
}

@booklet{Johnson97d,
   Author = {G. A. Johnson},
   Title = {Medicinal marijuana?},
   Journal = {New England Journal Of Medicine},
   Volume = {336},
   Number = {16},
   Pages = {1186 -- 1186},
   Year = {1997},
   Month = {April},
   Key = {Johnson97d}
}

@booklet{Vandemark97,
   Author = {Vandemark, RM and Fay, ME and Porter, FR and Johnson,
             GA},
   Title = {Digital image-intensifier radiography at a level I trauma
             center.},
   Journal = {AJR. American journal of roentgenology},
   Volume = {168},
   Number = {4},
   Pages = {944-946},
   Year = {1997},
   Month = {April},
   ISSN = {0361-803X},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/9124145},
   Doi = {10.2214/ajr.168.4.9124145},
   Key = {Vandemark97}
}

@article{fds174203,
   Author = {RM Vandemark and ME Fay and FR Porter and GA Johnson},
   Title = {Digital image-intensifier radiography at a level I trauma
             center.},
   Journal = {AJR. American journal of roentgenology},
   Volume = {168},
   Number = {4},
   Pages = {944-6},
   Year = {1997},
   Month = {April},
   ISSN = {0361-803X},
   Keywords = {Humans • Pelvis • Radiographic Image Enhancement
             • Radiography, Thoracic • Spinal Injuries •
             Spine • Trauma Centers • Wounds and Injuries
             • injuries • instrumentation* •
             radiography},
   Language = {eng},
   Key = {fds174203}
}

@booklet{Spencer97,
   Author = {T. A. Spencer and D. S. Clark and G. A. Johnson and S. K.
             Erickson and L. K. Curtiss},
   Title = {Feasibility of an immunoassay for mevalonolactone},
   Journal = {Bioorganic \& Medicinal Chemistry},
   Volume = {5},
   Number = {5},
   Pages = {873 -- 882},
   Year = {1997},
   Month = {May},
   Key = {Spencer97}
}

@article{fds132813,
   Author = {GA Johnson and H Benveniste and RT Engelhardt and H Qiu and LW
             Hedlund},
   Title = {Magnetic resonance microscopy in basic studies of brain
             structure and function.},
   Journal = {Annals of the New York Academy of Sciences, UNITED
             STATES},
   Volume = {820},
   Pages = {139-47; discussion 147-8},
   Year = {1997},
   Month = {May},
   ISSN = {0077-8923},
   Keywords = {Animals • Brain • Diagnostic Imaging • Humans
             • Microscopy • methods* • pathology •
             physiology • radiography*},
   Key = {fds132813}
}

@article{fds174267,
   Author = {TA Spencer and DS Clark and GA Johnson and SK Erickson and LK
             Curtiss},
   Title = {Feasibility of an immunoassay for mevalonolactone.},
   Journal = {Bioorganic & medicinal chemistry},
   Volume = {5},
   Number = {5},
   Pages = {873-82},
   Year = {1997},
   Month = {May},
   ISSN = {0968-0896},
   Keywords = {Animals • Antibody Formation • Haptens •
             Hemocyanin • Hydrogen-Ion Concentration •
             Immunoassay • Mevalonic Acid • Rabbits •
             Stereoisomerism • analogs & derivatives* •
             analysis • chemistry • immunology •
             methods*},
   Abstract = {Mevalonic acid is a key intermediate in a broad spectrum of
             cellular biological processes and their regulation.
             Availability of a rapid, sensitive and accurate method for
             its assay would be highly useful. Therefore, the feasibility
             of developing an immunoassay for mevalonic acid in
             biological samples was explored. The strategy employed was
             to synthesize several racemic haptens structurally
             resembling R-mevalonolactone, the cyclic form of mevalonic
             acid present at lower pH and presumed to be more antigenic.
             Two of these haptens were coupled to keyhole limpet
             hemocyanin, and the resulting conjugates were used
             successfully to generate antibodies in rabbits. The first
             antiserum bound to R,S-mevalonolactone much more effectively
             at pH 4.0 than at pH 6.0, consistent with the structural
             resemblance of the haptens to the lactone form. This
             antiserum also bound the free hapten from which it was
             generated and two others of different structure with
             comparable effectiveness; and slightly better than it bound
             R,S-mevalonolactone at pH 4.0. Similar results were obtained
             with the antiserum to the second hapten. The binding of
             either antiserum to the natural enantiomer,
             R-mevalonolactone, was 20 times weaker than to
             R,S-mevalonolactone, suggesting that the nonbiological
             enantiomer was more antigenic. Nevertheless, the results
             demonstrate that an immunochemical approach to accurate
             quantitation of mevalonic acid in biological samples is
             feasible.},
   Language = {eng},
   Key = {fds174267}
}

@booklet{Johnson97a,
   Author = {Johnson, GA and Benveniste, H and Engelhardt, RT and Qiu, H and Hedlund,
             LW},
   Title = {Magnetic resonance microscopy in basic studies of brain
             structure and function.},
   Journal = {Annals of the New York Academy of Sciences},
   Volume = {820},
   Series = {ANNALS OF THE NEW YORK ACADEMY OF SCIENCES},
   Pages = {139-147},
   Year = {1997},
   Month = {May},
   ISSN = {0077-8923},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/9237453},
   Key = {Johnson97a}
}

@booklet{Johnson97c,
   Author = {G. A. Johnson and R. Mannel and M. Khalifa and J. L. Walker and M. Wren and K. W. Min and D. M. Benbrook},
   Title = {Epidermal growth factor receptor in vulvar malignancies and
             its relationship to metastasis and patient
             survival},
   Journal = {Gynecologic Oncology},
   Volume = {65},
   Number = {3},
   Pages = {425 -- 429},
   Year = {1997},
   Month = {June},
   Key = {Johnson97c}
}

@article{fds174146,
   Author = {GA Johnson and R Mannel and M Khalifa and JL Walker and M Wren and KW Min and DM Benbrook},
   Title = {Epidermal growth factor receptor in vulvar malignancies and
             its relationship to metastasis and patient
             survival.},
   Journal = {Gynecologic oncology},
   Volume = {65},
   Number = {3},
   Pages = {425-9},
   Year = {1997},
   Month = {June},
   ISSN = {0090-8258},
   url = {http://dx.doi.org/10.1006/gyno.1997.4660},
   Keywords = {Carcinoma, Squamous Cell • Disease-Free Survival •
             Female • Humans • Lymphatic Metastasis •
             Receptor, Epidermal Growth Factor • Survival Rate
             • Vulvar Neoplasms • biosynthesis* •
             metabolism* • mortality • mortality* •
             pathology},
   Abstract = {OBJECTIVE: To evaluate the level of epidermal growth factor
             receptor (EGF-R) expression in vulvar malignancies and to
             determine if a correlation exists between EGF-R levels and
             metastasis or patient survival. METHODS: All patients with a
             diagnosis of invasive squamous cell carcinoma of the vulva
             who were treated at our institution with a primary radical
             vulvectomy and inguinal lymph node dissection from 1983 to
             1993 were eligible for the study. Sixty-one patients with
             available tissue blocks of benign vulvar epithelium, the
             primary malignant vulvar lesion, and groin node metastasis
             (when positive) were included in the study. Semiquantitative
             EGF-R expression was determined in a blinded fashion
             utilizing immunohistochemical staining of appropriate tissue
             samples. Survival was calculated utilizing Kaplan-Meier life
             table analysis based upon disease-free survival. RESULTS: A
             significant increase (P < 0.001) in mean EGF-R levels was
             demonstrated in the primary tumor (67%) versus benign vulvar
             epithelium (31%). In the 14 patients with lymph node
             metastasis, the mean EGF-R level in the primary tumor was
             65% versus 88% in the metastatic lesion (P < 0.001). The
             likelihood of lymph node metastasis was elevated in those
             patients with a benign tissue EGF-R level > or =40% (P <
             0.03) and in those patients with a primary tumor EGF-R level
             > or =90% (P < 0.025). Life table analysis revealed a
             cumulative disease-free survival of 45% for all patients.
             Disease-free survival in those patients with EGF-R levels >
             or =90% in the primary tumor was 25%, contrasting with a
             disease-free survival of 54% in those patients with EGF-R
             levels <90% (P < 0.05). CONCLUSIONS: There is a progressive
             increase in EGF-R expression from benign vulvar epithelium
             to primary malignant tissue to metastatic lesions within the
             same patient. Increased expression of EGF-R in the primary
             vulvar malignancy is significantly associated with lymph
             node metastasis and decreased patient survival. Increased
             expression of EGF-R in histologically benign vulvar
             epithelium has a significant association with lymph node
             metastasis and may predict decreased patient
             survival.},
   Language = {eng},
   Doi = {10.1006/gyno.1997.4660},
   Key = {fds174146}
}

@booklet{Mcfall97,
   Author = {McFall, JS and Johnson, GA},
   Title = {Root form and function meshed by MRI.},
   Journal = {Plant physiology},
   Volume = {114},
   Number = {3},
   Pages = {20002-20002},
   Year = {1997},
   Month = {July},
   ISSN = {0032-0889},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997XL11900006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Mcfall97}
}

@booklet{Johnson97b,
   Author = {Johnson, GA and Cates, G and Chen, XJ and Cofer, GP and Driehuys, B and Happer, W and Hedlund, LW and Saam, B and Shattuck, MD and Swartz,
             J},
   Title = {Dynamics of magnetization in hyperpolarized gas MRI of the
             lung.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {38},
   Number = {1},
   Pages = {66-71},
   Year = {1997},
   Month = {July},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/9211381},
   Abstract = {The magnetization in hyperpolarized gas (HP) MRI is
             generated by laser polarization that is independent of the
             magnet and imaging process. As a consequence, there is no
             equilibrium magnetization during the image acquisition. The
             competing processes of gas inflow and depolarization of the
             spins lead to large changes in signal as one samples
             k-space. A model is developed of dynamic changes in
             polarization of hyperpolarized 3He during infusion and in
             vivo imaging of the lung and verified experimentally in a
             live guinea pig. Projection encoding is used to measure the
             view-to-view variation with temporal resolution < 4 ms.
             Large excitation angles effectively sample the magnetization
             in the early stages of inflow, highlighting larger airways,
             while smaller excitation angles produce images of the more
             distal spaces. The work provides a basis for pulse sequences
             designed to effectively exploit HP MRI in the
             lung.},
   Key = {Johnson97b}
}

@article{fds132844,
   Author = {GA Johnson and G Cates and XJ Chen and GP Cofer and B Driehuys and W
             Happer, LW Hedlund and B Saam, MD Shattuck and J
             Swartz},
   Title = {Dynamics of magnetization in hyperpolarized gas MRI of the
             lung.},
   Journal = {Magnetic resonance in medicine : official journal of the
             Society of Magnetic Resonance in Medicine / Society of
             Magnetic Resonance in Medicine, UNITED STATES},
   Volume = {38},
   Number = {1},
   Pages = {66-71},
   Year = {1997},
   Month = {July},
   ISSN = {0740-3194},
   Keywords = {Animals • Guinea Pigs • Helium • Isotopes
             • Lung • Magnetic Resonance Imaging • Male
             • Respiration • anatomy & histology* •
             diagnostic use* • methods*},
   Abstract = {The magnetization in hyperpolarized gas (HP) MRI is
             generated by laser polarization that is independent of the
             magnet and imaging process. As a consequence, there is no
             equilibrium magnetization during the image acquisition. The
             competing processes of gas inflow and depolarization of the
             spins lead to large changes in signal as one samples
             k-space. A model is developed of dynamic changes in
             polarization of hyperpolarized 3He during infusion and in
             vivo imaging of the lung and verified experimentally in a
             live guinea pig. Projection encoding is used to measure the
             view-to-view variation with temporal resolution < 4 ms.
             Large excitation angles effectively sample the magnetization
             in the early stages of inflow, highlighting larger airways,
             while smaller excitation angles produce images of the more
             distal spaces. The work provides a basis for pulse sequences
             designed to effectively exploit HP MRI in the
             lung.},
   Key = {fds132844}
}

@booklet{Croft97,
   Author = {P. J. Croft and R. L. Pfost and J. M. Medlin and G. A.
             Johnson},
   Title = {Fog forecasting for the southern region: A conceptual model
             approach},
   Journal = {Weather And Forecasting},
   Volume = {12},
   Number = {3},
   Pages = {545 -- 556},
   Year = {1997},
   Month = {September},
   Key = {Croft97}
}

@booklet{Locher97a,
   Author = {M. Locher and G. A. Johnson and E. R. Hunt},
   Title = {Stabilizing spatiotemporal patterns in a convectively
             unstable open flow system via kink-antikink
             pairs},
   Journal = {Chaos Solitons \& Fractals},
   Volume = {8},
   Number = {9},
   Pages = {1523 -- 1532},
   Year = {1997},
   Month = {September},
   Key = {Locher97a}
}

@booklet{Hansen97,
   Author = {T. R. Hansen and K. J. Austin and G. A. Johnson},
   Title = {Transient ubiquitin cross-reactive protein gene expression
             in the bovine endometrium},
   Journal = {Endocrinology},
   Volume = {138},
   Number = {11},
   Pages = {5079 -- 5082},
   Year = {1997},
   Month = {November},
   Key = {Hansen97}
}

@booklet{Qiu97,
   Author = {Qiu, HH and Cofer, GP and Hedlund, LW and Johnson,
             GA},
   Title = {Automated feedback control of body temperature for small
             animal studies with MR microscopy.},
   Journal = {IEEE Transactions on Biomedical Engineering},
   Volume = {44},
   Number = {11},
   Pages = {1107-1113},
   Year = {1997},
   Month = {November},
   ISSN = {0018-9294},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/9353990},
   Abstract = {A temperature control system consisting of a thermistor,
             signal processor, and computer algorithm was developed for
             magnetic resonance (MR) microscopy of small live animals.
             With control of body temperature within +/- 0.2 degree C of
             the set point, heart rate is stabilized and, in turn,
             repetition time (TR) during cardiac-gated studies is less
             variable. Thus, image quality and resolution are
             improved.},
   Doi = {10.1109/10.641338},
   Key = {Qiu97}
}

@article{fds132756,
   Author = {HH Qiu and GP Cofer and LW Hedlund and GA Johnson},
   Title = {Automated feedback control of body temperature for small
             animal studies with MR microscopy.},
   Journal = {IEEE transactions on bio-medical engineering, UNITED
             STATES},
   Volume = {44},
   Number = {11},
   Pages = {1107-13},
   Year = {1997},
   Month = {November},
   ISSN = {0018-9294},
   Keywords = {Animals • Body Temperature • Equipment Design
             • Feedback • Ferrets • Guinea Pigs •
             Magnetic Resonance Imaging • Mice • Microscopy
             • Models, Biological • Monitoring, Physiologic
             • Rats • Respiration, Artificial • Signal
             Processing, Computer-Assisted* • Thermometers* •
             instrumentation • methods • physiology*},
   Abstract = {A temperature control system consisting of a thermistor,
             signal processor, and computer algorithm was developed for
             magnetic resonance (MR) microscopy of small live animals.
             With control of body temperature within +/- 0.2 degree C of
             the set point, heart rate is stabilized and, in turn,
             repetition time (TR) during cardiac-gated studies is less
             variable. Thus, image quality and resolution are
             improved.},
   Key = {fds132756}
}

@article{fds174248,
   Author = {TR Hansen and KJ Austin and GA Johnson},
   Title = {Transient ubiquitin cross-reactive protein gene expression
             in the bovine endometrium.},
   Journal = {Endocrinology},
   Volume = {138},
   Number = {11},
   Pages = {5079-82},
   Year = {1997},
   Month = {November},
   ISSN = {0013-7227},
   Keywords = {Animals • Blotting, Northern • Cattle •
             Endometrium • Estrus • Female • Gene
             Expression* • Glyceraldehyde-3-Phosphate Dehydrogenases
             • Interferon Type I • Pregnancy • Pregnancy
             Proteins • RNA, Messenger • Time Factors •
             Transcription, Genetic • Ubiquitins • analogs &
             derivatives* • drug effects • genetics •
             metabolism • pharmacology • physiology*},
   Abstract = {Bovine ubiquitin cross-reactive protein (boUCRP) is secreted
             by the endometrium from days 15 to 26 of pregnancy in
             response to conceptus-derived interferon-tau (IFN-tau). We
             hypothesized that the gene encoding boUCRP was under
             transcriptional control by the conceptus and IFN-tau.
             Northern blots using radiolabeled UCRP cDNA revealed a
             single UCRP transcript of approximately 700 b that was
             present (P < 0.05) in endometrial cells cultured with 25 nM
             rboIFN-tau. The UCRP mRNA was not detected in endometrium on
             days 15, 17, 18 or 19 of the estrous cycle (n = 4 cows on
             each day) or in spleen, kidney, liver, corpus luteum or
             muscle. Bovine UCRP mRNA was detectable (P < 0.05) in
             endometrium from pregnant cows by day 15, reached highest
             levels by day 17, remained elevated on days 18, 19 and 21,
             and then declined to amounts on day 26 that were not
             detectable. Northern blot using radiolabeled ubiquitin cDNA
             revealed presence of the two major ubiquitin transcripts UbB
             (1.2 Kb) and UbC (2.6 Kb) in all tissues examined. The
             bovine UCRP cDNA did not cross-hybridize with these
             ubiquitin transcripts. We conclude that transcription of the
             UCRP gene is transient during early pregnancy and regulated
             by IFN-tau.},
   Language = {eng},
   Key = {fds174248}
}

@booklet{Locher97,
   Author = {M. Locher and G. A. Johnson and E. R. Hunt},
   Title = {Stability analysis of fixed points via chaos
             control},
   Journal = {Chaos},
   Volume = {7},
   Number = {4},
   Pages = {590 -- 596},
   Year = {1997},
   Month = {December},
   Key = {Locher97}
}

@booklet{Pecora97,
   Author = {L. M. Pecora and T. L. Carroll and G. A. Johnson and D. J.
             Mar and J. F. Heagy},
   Title = {Fundamentals of synchronization in chaotic systems,
             concepts, and applications},
   Journal = {Chaos},
   Volume = {7},
   Number = {4},
   Pages = {520 -- 543},
   Year = {1997},
   Month = {December},
   Key = {Pecora97}
}

@booklet{Shattuck97,
   Author = {Shattuck, MD and Gewalt, SL and Glover, GH and Hedlund, LW and Johnson,
             GA},
   Title = {MR microimaging of the lung using volume projection
             encoding.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {38},
   Number = {6},
   Pages = {938-942},
   Year = {1997},
   Month = {December},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/9402195},
   Abstract = {Radial acquisition (RA) techniques have been extended to
             produce isotropic, three-dimensional images of lung in live
             laboratory animals at spatial resolution down to 0.013 mm3
             with a signal-to-noise ratio of 30:1. The pulse sequence and
             reconstruction algorithm have been adapted to allow
             acquisition of image matrices of up to 256(3) in less than
             15 min. Scan-synchronous ventilation has been incorporated
             to limit breathing motion artifacts. The imaging sequence
             permits randomizing and/or discarding selected views to
             minimize the consequences of breathing motion. The signal in
             lung parenchyma was measured as a function of flip angle
             (alpha) for different repetition times and found to follow
             the predictions for which there is an optimum excitation
             (Ernst) angle. A single T1 relaxation value of 780 +/- 54 ms
             fits all data from six guinea pigs at 2.0 T. This T1 value
             parameterizes the signal and allows for a priori
             optimization, such as calculation of the Ernst angle
             appropriate for lung imaging.},
   Key = {Shattuck97}
}

@article{fds132777,
   Author = {MD Shattuck and SL Gewalt and GH Glover and LW Hedlund and GA
             Johnson},
   Title = {MR microimaging of the lung using volume projection
             encoding.},
   Journal = {Magnetic resonance in medicine : official journal of the
             Society of Magnetic Resonance in Medicine / Society of
             Magnetic Resonance in Medicine, UNITED STATES},
   Volume = {38},
   Number = {6},
   Pages = {938-42},
   Year = {1997},
   Month = {December},
   ISSN = {0740-3194},
   Keywords = {Animals • Guinea Pigs • Lung • Magnetic
             Resonance Imaging • anatomy & histology* •
             methods*},
   Abstract = {Radial acquisition (RA) techniques have been extended to
             produce isotropic, three-dimensional images of lung in live
             laboratory animals at spatial resolution down to 0.013 mm3
             with a signal-to-noise ratio of 30:1. The pulse sequence and
             reconstruction algorithm have been adapted to allow
             acquisition of image matrices of up to 256(3) in less than
             15 min. Scan-synchronous ventilation has been incorporated
             to limit breathing motion artifacts. The imaging sequence
             permits randomizing and/or discarding selected views to
             minimize the consequences of breathing motion. The signal in
             lung parenchyma was measured as a function of flip angle
             (alpha) for different repetition times and found to follow
             the predictions for which there is an optimum excitation
             (Ernst) angle. A single T1 relaxation value of 780 +/- 54 ms
             fits all data from six guinea pigs at 2.0 T. This T1 value
             parameterizes the signal and allows for a priori
             optimization, such as calculation of the Ernst angle
             appropriate for lung imaging.},
   Key = {fds132777}
}

@article{fds174115,
   Author = {LM Pecora and TL Carroll and GA Johnson and DJ Mar and JF
             Heagy},
   Title = {Fundamentals of synchronization in chaotic systems,
             concepts, and applications.},
   Journal = {Chaos (Woodbury, N.Y.)},
   Volume = {7},
   Number = {4},
   Pages = {520-543},
   Year = {1997},
   Month = {December},
   ISSN = {1089-7682},
   url = {http://dx.doi.org/10.1063/1.166278},
   Abstract = {The field of chaotic synchronization has grown considerably
             since its advent in 1990. Several subdisciplines and
             "cottage industries" have emerged that have taken on bona
             fide lives of their own. Our purpose in this paper is to
             collect results from these various areas in a review article
             format with a tutorial emphasis. Fundamentals of chaotic
             synchronization are reviewed first with emphases on the
             geometry of synchronization and stability criteria. Several
             widely used coupling configurations are examined and, when
             available, experimental demonstrations of their success
             (generally with chaotic circuit systems) are described.
             Particular focus is given to the recent notion of
             synchronous substitution-a method to synchronize chaotic
             systems using a larger class of scalar chaotic coupling
             signals than previously thought possible. Connections
             between this technique and well-known control theory results
             are also outlined. Extensions of the technique are presented
             that allow so-called hyperchaotic systems (systems with more
             than one positive Lyapunov exponent) to be synchronized.
             Several proposals for "secure" communication schemes have
             been advanced; major ones are reviewed and their strengths
             and weaknesses are touched upon. Arrays of coupled chaotic
             systems have received a great deal of attention lately and
             have spawned a host of interesting and, in some cases,
             counterintuitive phenomena including bursting above
             synchronization thresholds, destabilizing transitions as
             coupling increases (short-wavelength bifurcations), and
             riddled basins. In addition, a general mathematical
             framework for analyzing the stability of arrays with
             arbitrary coupling configurations is outlined. Finally, the
             topic of generalized synchronization is discussed, along
             with data analysis techniques that can be used to decide
             whether two systems satisfy the mathematical requirements of
             generalized synchronization. (c) 1997 American Institute of
             Physics.},
   Language = {ENG},
   Doi = {10.1063/1.166278},
   Key = {fds174115}
}

@article{fds174169,
   Author = {M Locher and GA Johnson and ER Hunt},
   Title = {Stability analysis of fixed points via chaos
             control.},
   Journal = {Chaos (Woodbury, N.Y.)},
   Volume = {7},
   Number = {4},
   Pages = {590-596},
   Year = {1997},
   Month = {December},
   ISSN = {1089-7682},
   url = {http://dx.doi.org/10.1063/1.166258},
   Abstract = {This paper reviews recent advances in the application of
             chaos control techniques to the stability analysis of
             two-dimensional dynamical systems. We demonstrate how the
             system's response to one or multiple feedback controllers
             can be utilized to calculate the characteristic multipliers
             associated with an unstable periodic orbit. The experimental
             results, obtained for a single and two coupled diode
             resonators, agree well with the presented theory. (c) 1997
             American Institute of Physics.},
   Language = {ENG},
   Doi = {10.1063/1.166258},
   Key = {fds174169}
}

@booklet{Johnson98d,
   Author = {G. A. Johnson and T. R. Hoverstad and R. E.
             Greenwald},
   Title = {Integrated weed management using narrow corn row spacing,
             herbicides, and cultivation},
   Journal = {Agronomy Journal},
   Volume = {90},
   Number = {1},
   Pages = {40 -- 46},
   Year = {1998},
   Key = {Johnson98d}
}

@booklet{Lindquist98,
   Author = {J. L. Lindquist and J. A. Dieleman and D. A. Mortensen and G. A. Johnson and D. Y. Wyse-pester},
   Title = {Economic importance of managing spatially heterogeneous weed
             populations},
   Journal = {Weed Technology},
   Volume = {12},
   Number = {1},
   Pages = {7 -- 13},
   Year = {1998},
   Key = {Lindquist98}
}

@booklet{Griffin98,
   Author = {W. P. Griffin and E. B. Savage and R. E. Clark and J. J.
             Pacella and G. A. Johnson and J. A. Magovern and G. J.
             Magovern},
   Title = {AB-180 circulatory support system - Summary of development
             and phase I clinical trial},
   Journal = {Asaio Journal},
   Volume = {44},
   Number = {5},
   Pages = {M719 -- M724},
   Year = {1998},
   Key = {Griffin98}
}

@article{fds268763,
   Author = {Smith, BR and Sattuck, MD and Hedlund, LW and Johnson,
             GA},
   Title = {Erratum: Time-course imaging of rat embryos in utero with
             magnetic resonance microscopy (Magnetic Resonance in
             Medicine (1998) 39 (673-677))},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {39},
   Number = {6},
   Pages = {x},
   Year = {1998},
   Key = {fds268763}
}

@article{fds268764,
   Author = {Benveniste, H and Einstein, G and Kim, KR and Johnson,
             GA},
   Title = {Magnetic resonance microscopy of Alzheimer's disease: Senile
             plaques - A whiter shade of pale?},
   Journal = {NeuroImage},
   Volume = {7},
   Number = {4 PART II},
   Pages = {S519},
   Year = {1998},
   Key = {fds268764}
}

@booklet{Levron98,
   Author = {Levron, D and Walter, DK and Appelt, S and Fitzgerald, RJ and Kahn, D and Korbly, SE and Sauer, KL and Happer, W and Earles, TL and Mawst, LJ and al,
             E},
   Title = {Magnetic resonance imaging of hyperpolarized 129Xe produced
             by spin exchange with diode-laser pumped
             Cs},
   Journal = {Applied Physics Letters},
   Volume = {73},
   Number = {18},
   Pages = {2666-2668},
   Year = {1998},
   url = {http://dx.doi.org/10.1063/1.122547},
   Abstract = {We report the results of experiments leading to the
             production of an image of a polarized 129Xe sample prepared
             by spin exchange with Cs, optically pumped with a spectrally
             narrowed 894.3 nm diode laser. Representative images of the
             average electron spin polarization are shown. Appreciable
             cesium electron polarization values were achieved, and a
             nuclear polarization of about 2.5% was measured for 129Xe.
             The absolute nuclear polarization was measured by
             water-calibrated free induction decay of the nuclear
             magnetic resonance signal, and the polarized xenon imaged
             using a 2 T magnetic resonance imaging system. © 1998
             American Institute of Physics.},
   Doi = {10.1063/1.122547},
   Key = {Levron98}
}

@booklet{Johnson98,
   Author = {Johnson, GA and Hedlund, L and MacFall, J},
   Title = {A new window into the lung},
   Journal = {Physics World},
   Volume = {11},
   Number = {11},
   Pages = {35-38},
   Year = {1998},
   ISSN = {0953-8585},
   Key = {Johnson98}
}

@article{fds132724,
   Title = {Viallon M, Cofer GP, Suddarth SA, Msller H, Chen XJ, Chawla
             MS, Hedlund LW, Cr Millieux Y, Johson GA. Functional MR
             microscopy of the lung with hyperpolarized 3He. Mag Reson
             Med. In press 1998},
   Year = {1998},
   Key = {fds132724}
}

@article{fds132725,
   Title = {Delnomdedieu M, Hedlund LW, maronpot RR, Johson GA, MR
             microscopy and histopathology: Comparative approach to
             bromobenzene-induced hepatoxicity in the rat. hepatology 27;
             526-532 1998},
   Year = {1998},
   Key = {fds132725}
}

@article{fds132745,
   Title = {Hurlston SE, Brey WW, Suddarth SA, Yap M, Johson GA. A high
             temperature superconducting Helmholtz probe for microscopy
             at 9.4 T Magn Res Med. In press 1998},
   Year = {1998},
   Key = {fds132745}
}

@article{fds132746,
   Title = {Johnson GA, Hedlund LW, MacFall JR. A new window into the
             lung. Physics in Medicine 35-38 1998},
   Year = {1998},
   Key = {fds132746}
}

@article{fds132747,
   Title = {Miller JR, Hurlston SE, Face DW, Kountz DJ, MacFall JR,
             Hedlund LW, Ma QY, Johnson GA. Performance of a
             high-temperature superconducting probe for in vivo microsopy
             at 2.0 T Magn Reson Med. In press 1998},
   Year = {1998},
   Key = {fds132747}
}

@booklet{Johnson98a,
   Author = {G. A. Johnson and C. A. Gray and J. B. Word and T. L. Ott and T. E. Spencer and R. C. Burghardt and F. W.
             Bazer},
   Title = {Expression and secretion of osteopontin by ovine endometrium
             and conceptuses.},
   Journal = {Biology Of Reproduction},
   Volume = {58},
   Pages = {119 -- 119},
   Year = {1998},
   Key = {Johnson98a}
}

@booklet{Chen98a,
   Author = {X. J. Chen and M. S. Chawla and L. W. Hedlund and H. E.
             Moller and J. R. Macfall and G. A. Johnson},
   Title = {MR microscopy of lung airways with hyperpolarized
             He-3},
   Journal = {Magnetic Resonance In Medicine},
   Volume = {39},
   Number = {1},
   Pages = {79 -- 84},
   Year = {1998},
   Month = {January},
   Key = {Chen98a}
}

@booklet{Zhou98,
   Author = {Zhou, X and Liang, ZP and Gewalt, SL and Cofer, GP and Lauterbur, PC and Johnson, GA},
   Title = {A fast spin echo technique with circular
             sampling.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {39},
   Number = {1},
   Pages = {23-27},
   Year = {1998},
   Month = {January},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/9438433},
   Abstract = {This paper presents a fast spin echo (FSE) imaging method
             that employs circular sampling of k-space. The technique has
             been implemented on a 2 Tesla imaging system and validated
             on both phantoms and living animals. Experimental studies
             have shown that circular sampling can produce artifact-free
             FSE images without the need of phase correction. Although
             not fully explored, preliminary results also show that
             circular sampling may have advantages over the conventional
             rectilinear FSE in signal-to-noise ratio and imaging
             efficiency. A major disadvantage is the increased
             sensitivity to off-resonance effects. The authors expect
             that the FSE technique with circular sampling will find its
             applications in magnetic resonance microscopy,
             neuro-functional imaging, and real-time dynamic
             studies.},
   Key = {Zhou98}
}

@article{fds132829,
   Author = {X Zhou and ZP Liang and SL Gewalt and GP Cofer and PC Lauterbur and GA
             Johnson},
   Title = {A fast spin echo technique with circular
             sampling.},
   Journal = {Magnetic resonance in medicine : official journal of the
             Society of Magnetic Resonance in Medicine / Society of
             Magnetic Resonance in Medicine, UNITED STATES},
   Volume = {39},
   Number = {1},
   Pages = {23-7},
   Year = {1998},
   Month = {January},
   ISSN = {0740-3194},
   Keywords = {Animals • Brain • Echo-Planar Imaging • Image
             Processing, Computer-Assisted • Magnetic Resonance
             Imaging • Models, Theoretical • Phantoms, Imaging*
             • Rats • Sensitivity and Specificity •
             anatomy & histology* • instrumentation • methods
             • methods*},
   Abstract = {This paper presents a fast spin echo (FSE) imaging method
             that employs circular sampling of k-space. The technique has
             been implemented on a 2 Tesla imaging system and validated
             on both phantoms and living animals. Experimental studies
             have shown that circular sampling can produce artifact-free
             FSE images without the need of phase correction. Although
             not fully explored, preliminary results also show that
             circular sampling may have advantages over the conventional
             rectilinear FSE in signal-to-noise ratio and imaging
             efficiency. A major disadvantage is the increased
             sensitivity to off-resonance effects. The authors expect
             that the FSE technique with circular sampling will find its
             applications in magnetic resonance microscopy,
             neuro-functional imaging, and real-time dynamic
             studies.},
   Key = {fds132829}
}

@article{fds268952,
   Author = {Chen, XJ and Chawla, MS and Hedlund, LW and Möller, HE and MacFall, JR and Johnson, GA},
   Title = {MR microscopy of lung airways with hyperpolarized
             3He.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {39},
   Number = {1},
   Pages = {79-84},
   Year = {1998},
   Month = {January},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/9438440},
   Keywords = {Animals • Disease Models, Animal • Guinea Pigs
             • Helium • Humans • Image Enhancement •
             Isotopes • Lung • Magnetic Resonance Imaging
             • Male • Microscopy • Middle Aged •
             Pulmonary Gas Exchange • Reference Values •
             Sensitivity and Specificity • anatomy & histology*
             • diagnostic use* • methods • methods* •
             physiology},
   Abstract = {A technique using hyperpolarized (HP) 3He to image the small
             airways of the lung by using moderate flip angles and a
             short scanning period during early inspiration is
             demonstrated. Flip angles (alpha) ranging from 10-90 degrees
             were used in guinea pig experiments with scanning during the
             entire inspiration period. A second series acquired data
             throughout a short window of the ventilatory cycle with
             alpha = 45 degrees. The success of the animal studies has
             motivated implementation of similar imaging techniques in
             the clinical arena. Human studies involved imaging over the
             total inspiration period with alpha approximately 10
             degrees. The first series of guinea pig experiments
             demonstrated that larger flip angles (50-90 degrees) destroy
             the magnetization before it reaches the smaller airways. At
             moderate flip angles (20-40 degrees), airway branching down
             to the fourth generation was apparent. Fifth-order
             branchings were seen in the images of the second series. The
             trachea down to fourth generation pulmonary airway
             branching, along with some distal air spaces, was seen in
             the human lung images.},
   Key = {fds268952}
}

@booklet{Shen-gunther98,
   Author = {J. Shen-gunther and R. S. Mannel and J. L. Walker and G. A.
             Johnson and A. E. Sienko},
   Title = {Laparoscopic paraaortic lymphadenectomy using laparosonic
             coagulating shears},
   Journal = {Journal Of The American Association Of Gynecologic
             Laparoscopists},
   Volume = {5},
   Number = {1},
   Pages = {47 -- 50},
   Year = {1998},
   Month = {February},
   Key = {Shen-gunther98}
}

@booklet{Carroll98,
   Author = {T. L. Carroll and G. A. Johnson},
   Title = {Synchronizing broadband chaotic systems to narrow-band
             signals},
   Journal = {Physical Review E},
   Volume = {57},
   Number = {2},
   Pages = {1555 -- 1558},
   Year = {1998},
   Month = {February},
   Key = {Carroll98}
}

@booklet{Delnomdedieu98,
   Author = {M. Delnomdedieu and L. W. Hedlund and R. R. Maronpot and G.
             A. Johnson},
   Title = {Magnetic resonance microscopy and histopathology:
             Comparative approach of bromobenzene-induced hepatotoxicity
             in the rat},
   Journal = {Hepatology},
   Volume = {27},
   Number = {2},
   Pages = {526 -- 532},
   Year = {1998},
   Month = {February},
   Key = {Delnomdedieu98}
}

@article{fds174302,
   Author = {J Shen-Gunther and RS Mannel and JL Walker and GA Johnson and AE
             Sienko},
   Title = {Laparoscopic paraaortic lymphadenectomy using laparosonic
             coagulating shears.},
   Journal = {The Journal of the American Association of Gynecologic
             Laparoscopists},
   Volume = {5},
   Number = {1},
   Pages = {47-50},
   Year = {1998},
   Month = {February},
   ISSN = {1074-3804},
   Keywords = {Adult • Carcinoma, Squamous Cell • Female •
             Hemostasis, Surgical • Humans • Laparoscopes*
             • Laparoscopy • Lymph Node Excision • Middle
             Aged • Surgical Instruments • Time Factors •
             Ultrasonics • Uterine Cervical Neoplasms •
             instrumentation • methods • methods* •
             surgery},
   Abstract = {With marked innovations in endosurgical instrumentation,
             operative laparoscopy to include lymphadenectomy has become
             feasible and has a valuable role in the management of
             gynecologic malignancy. We used laparosonic coagulating
             shears (LCS) for laparoscopic paraaortic lymphadenectomy in
             two women with cervical carcinoma. Operating times for the
             laparoscopic portion were 55 and 65 minutes and blood loss
             was 20 and 30 ml, respectively. No surgical complications
             were encountered. Lymphatic tissues were evaluated
             histologically and no thermal artifacts were identified. The
             major advantage of the ultrasonically activated scalpel of
             the LCS is the ability to cut and coagulate tissues
             simultaneously without electrical current. The LCS may
             afford the surgeon a greater margin of safety than unipolar
             electrocoagulation scissors by eliminating potential thermal
             and electrical injury to vital structures.
             Ultrasonic-activated technology deserves extended clinical
             investigation in laparoscopic lymphadenectomy to
             substantiate our preliminary findings, as well as to explore
             its potential in gynecologic oncology.},
   Language = {eng},
   Key = {fds174302}
}

@article{fds269045,
   Author = {Delnomdedieu, M and Hedlund, LW and Maronpot, RR and Johnson,
             GA},
   Title = {Magnetic resonance microscopy and histopathology:
             comparative approach of bromobenzene-induced hepatotoxicity
             in the rat.},
   Journal = {Hepatology},
   Volume = {27},
   Number = {2},
   Pages = {526-532},
   Year = {1998},
   Month = {February},
   ISSN = {0270-9139},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/9462653},
   Keywords = {Animals • Bromobenzenes* • Female •
             Histocytochemistry • Liver Diseases • Microscopy
             • Rats • Rats, Inbred F344 • Reproducibility
             of Results • Sensitivity and Specificity •
             chemically induced • methods* •
             pathology*},
   Abstract = {The development of magnetic resonance (MR) microscopy has
             provided new approaches to histology and histopathology.
             Recent work has shown the promise of increased sensitivity
             in animal models of chemically induced hepatotoxicity.
             However, the field is so new that there is little experience
             to relate changes seen in MR micrographs to the more
             traditional optical images stained with hematoxylin and
             eosin. This work compares the sensitivity and
             reproducibility of MR microscopy with conventional
             histopathology in detecting bromobenzene-induced
             hepatotoxicity in the rat. A time-course study was
             undertaken to provide a range of histopathologies. Specimens
             were studied at 24, 48, 72, and 96 hours after exposure to
             10% of the median lethal dose of bromobenzene. Using 4
             animals per group (a total of 32 rats) added statistical
             significance to the study and defined a range of interanimal
             variability over 96 hours. This work shows that MR
             microscopy, besides being nondestructive and
             three-dimensional, is at least as sensitive as conventional
             hematoxylin-eosin staining in detecting bromobenzene-induced
             centrilobular lesions and recovery of the hepatocellular
             architecture in the rat. This study further suggests that,
             as we begin to understand the underlying mechanisms of
             contrast in MR histology, MR may, in fact, supply even
             higher specificity than more traditional studies: variations
             were observed in MR images of treated livers at a given time
             point that could be not be differentiated based on the
             grading of necrosis and inflammation on hematoxylin-eosin-stained
             sections.},
   Doi = {10.1002/hep.510270229},
   Key = {fds269045}
}

@booklet{Johnson98c,
   Author = {G. A. Johnson and K. J. Austin and E. A. van Kirk and T. R.
             Hansen},
   Title = {Pregnancy and interferon-tau induce conjugation of bovine
             ubiquitin cross-reactive protein to cytosolic uterine
             proteins},
   Journal = {Biology Of Reproduction},
   Volume = {58},
   Number = {4},
   Pages = {898 -- 904},
   Year = {1998},
   Month = {April},
   Key = {Johnson98c}
}

@booklet{Smith98a,
   Author = {B. R. Smith and M. D. Shattuck and L. W. Hedlund and G. A.
             Johnson},
   Title = {Time-course imaging of rat embryos in utero with magnetic
             resonance microscopy},
   Journal = {Magnetic Resonance In Medicine},
   Volume = {39},
   Number = {4},
   Pages = {673 -- 677},
   Year = {1998},
   Month = {April},
   Key = {Smith98a}
}

@article{fds174288,
   Author = {GA Johnson and KJ Austin and EA Van Kirk and TR Hansen},
   Title = {Pregnancy and interferon-tau induce conjugation of bovine
             ubiquitin cross-reactive protein to cytosolic uterine
             proteins.},
   Journal = {Biology of reproduction},
   Volume = {58},
   Number = {4},
   Pages = {898-904},
   Year = {1998},
   Month = {April},
   ISSN = {0006-3363},
   Keywords = {Amino Acid Sequence • Animals • Blotting, Western
             • Carrier Proteins • Cattle • Cytosol •
             Densitometry • Female • Interferon Type I •
             Molecular Sequence Data • Pregnancy • Pregnancy
             Proteins • Pregnancy, Animal • Proteins •
             Recombinant Proteins • Ubiquitins • Uterus •
             analogs & derivatives* • chemistry • chemistry*
             • metabolism • metabolism* • pharmacology
             • pharmacology* • physiology* •
             ultrastructure},
   Abstract = {Conceptus-derived interferon-tau (IFN-tau) induces bovine
             endometrial ubiquitin cross-reactive protein (UCRP) mRNA and
             protein on Days 15-21 of pregnancy. Bovine UCRP retains the
             Leu-Arg-Gly-Gly C-terminal sequence of ubiquitin that
             ligates to and directs degradation of cytosolic proteins.
             The objectives of the present experiments were to determine
             whether UCRP became conjugated to endometrial cytosolic
             proteins during early pregnancy and in response to
             recombinant bovine (rbo) IFN-tau. Ubiquitin (8 kDa), UCRP
             (17 kDa), and conjugates thereof (> or = 30 kDa) were
             quantitated using Western blotting and densitometry.
             Endometrial ubiquitin and its conjugates did not differ
             between Day 18 pregnant and nonpregnant cows, or between
             control and rboIFN-tau-treated (25 nM) explant cultures (Day
             14; nonpregnant). Bovine UCRP was induced in endometrium
             from pregnant as compared with nonpregnant cows. Conjugation
             of endometrial proteins to UCRP was induced in pregnant as
             compared to nonpregnant cows. Recombinant boIFN-tau induced
             UCRP and its conjugates in cultured endometrial explants
             from nonpregnant cows. It is concluded that UCRP, in
             response to rboIFN-tau, becomes conjugated to endometrial
             cytosolic proteins during early pregnancy. The regulation of
             uterine proteins by UCRP may be integral to the maintenance
             of early pregnancy in ruminants.},
   Language = {eng},
   Key = {fds174288}
}

@article{fds268905,
   Author = {Smith, BR and Shattuck, MD and Hedlund, LW and Johnson,
             GA},
   Title = {Time-course imaging of rat embryos in utero with magnetic
             resonance microscopy.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {39},
   Number = {4},
   Pages = {673-677},
   Year = {1998},
   Month = {April},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/9543433},
   Keywords = {Animals • Embryo • Embryonic and Fetal Development
             • Female • Fetus • Follow-Up Studies •
             Gestational Age • Image Processing, Computer-Assisted
             • Magnetic Resonance Imaging • Pregnancy •
             Rats • Rats, Sprague-Dawley • Time Factors •
             Uterus • anatomy & histology • anatomy &
             histology* • methods*},
   Abstract = {Magnetic resonance (MR) microscopy was used to noninvasively
             investigate the development of live rat embryos in utero.
             The difficulty in making sequential observations of a
             developing mammalian embryo has frustrated developmental
             biologists for many years. Most current technologies analyze
             normal and abnormal development by observing end point
             phenotypes (in fixed specimens) rather than investigating
             the live embryo. MR microscopy was adapted to allow rat
             litters to be scanned three times each (at 1- to 3-day
             intervals) and has produced images of live developing
             embryos. It was demonstrated that repeated anesthesia and
             imaging protocols produced no gross malformations in the rat
             pups that were subsequently delivered and observed.
             Three-dimensional projection encoding with phase rewinders
             produced isotropic [256(3)] image data sets in about 30
             minutes with excellent tissue contrast arising from
             steady-state effects in the amniotic fluid.},
   Key = {fds268905}
}

@booklet{Johnson98b,
   Author = {G. A. Johnson and D. J. Mar and T. L. Carroll and L. M.
             Pecora},
   Title = {Synchronization and imposed bifurcations in the presence of
             large parameter mismatch},
   Journal = {Physical Review Letters},
   Volume = {80},
   Number = {18},
   Pages = {3956 -- 3959},
   Year = {1998},
   Month = {May},
   Key = {Johnson98b}
}

@booklet{Smith98,
   Author = {Smith, BR and Sattuck, MD and Hedlund, LW and Johnson,
             GA},
   Title = {Time-course imaging of rat embryos in utero with magnetic
             resonance microscopy (vol 39, pg 673, 1998)},
   Journal = {Magnetic Resonance In Medicine},
   Volume = {39},
   Number = {6},
   Pages = {CP2-CP2},
   Year = {1998},
   Month = {June},
   Key = {Smith98}
}

@booklet{Chen98,
   Author = {X. J. Chen and M. S. Chawla and G. P. Cofer and L. W.
             Hedlund and H. E. Moller and G. A. Johnson},
   Title = {Hyperpolarized He-3 NMR lineshape measurements in the live
             guinea pig lung},
   Journal = {Magnetic Resonance In Medicine},
   Volume = {40},
   Number = {1},
   Pages = {61 -- 65},
   Year = {1998},
   Month = {July},
   Key = {Chen98}
}

@booklet{Qiu98,
   Author = {H. H. Qiu and L. W. Hedlund and M. R. Neuman and C. R.
             Edwards and R. D. Black and G. P. Cofer and G. A.
             Johnson},
   Title = {Measuring the progression of foreign-body reaction to
             silicone implants using in vivo MR microscopy},
   Journal = {Ieee Transactions On Biomedical Engineering},
   Volume = {45},
   Number = {7},
   Pages = {921 -- 927},
   Year = {1998},
   Month = {July},
   Key = {Qiu98}
}

@article{fds268995,
   Author = {Qiu, HH and Hedlund, LW and Neuman, MR and Edwards, CR and Black, RD and Cofer, GP and Johnson, GA},
   Title = {Measuring the progression of foreign-body reaction to
             silicone implants using in vivo MR microscopy.},
   Journal = {IEEE Transactions on Biomedical Engineering},
   Volume = {45},
   Number = {7},
   Pages = {921-927},
   Year = {1998},
   Month = {July},
   ISSN = {0018-9294},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/9644901},
   Keywords = {Animals • Female • Foreign-Body Reaction •
             Magnetic Resonance Imaging* • Microscopy • Neck
             • Prostheses and Implants • Rats • Rats,
             Sprague-Dawley • Silicones • adverse effects*
             • etiology • methods • pathology* •
             surgery},
   Abstract = {We used in vivo magnetic resonance (MR) microscopy to follow
             the growth of fibrous capsule as a foreign body reaction to
             silicone implants in rats. Anesthetized rats were imaged 1,
             7, 14, and 28 days after silicone-coated MR imaging coils
             were sutured to their neck muscles. On the twenty-eighth
             day, rats were sacrificed and coils and adjacent tissues
             were removed en bloc and fixed in formalin, reimaged with
             MR, and sectioned for conventional histology.
             Three-dimensional (3-D) spin-echo [3DFT] acquisition gave
             in-plane resolution of 32 x 32 microns in vivo and 16 x 16
             microns ex vivo. All MR images showed a diffuse band of
             elevated signal intensity between the silicone of the coil
             and adjacent tissue. The border of the hyperintense band was
             thin and not well defined at seven days post-implantation.
             From 7-28 days, the band showed relatively homogeneous
             signal intensity and its thickness increased 44% on the
             rectus muscle side and 78% on the subcutaneous side. The
             capsule thickness determined either by MR in vivo and ex
             vivo microscopy or conventional histology was not
             significantly different, and there was a significant
             correlation between thickness measurements among those
             methods. MR in vivo microscopy provides sufficient
             resolution and spatial information to serially evaluate the
             growth of the foreign body fibrous capsule over time, thus
             achieving greater accuracy and consistency in
             measurements.},
   Doi = {10.1109/10.686800},
   Key = {fds268995}
}

@article{fds269124,
   Author = {Chen, XJ and Chawla, MS and Cofer, GP and Hedlund, LW and Möller, HE and Johnson, GA},
   Title = {Hyperpolarized 3He NMR lineshape measurements in the live
             guinea pig lung.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {40},
   Number = {1},
   Pages = {61-65},
   Year = {1998},
   Month = {July},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/9660554},
   Keywords = {Animals • Guinea Pigs • Helium • Isotopes
             • Lung • Magnetic Resonance Spectroscopy •
             Pulmonary Gas Exchange • Reference Values •
             Respiratory Mechanics • Sensitivity and Specificity
             • anatomy & histology* • diagnostic use* •
             methods*},
   Abstract = {Spatially localized lineshapes of hyperpolarized (HP) 3He in
             guinea pig lungs have been measured in vivo. Three different
             axial slice locations, each containing different
             compositions of airway sizes and orientations, were studied.
             Gas peaks from major bronchi (2 ppm) and alveoli (-2 ppm)
             were distinguished. The gas phase spectra show structural
             features that are a result of frequency shifts caused by
             bulk magnetic susceptibility. For a given slice, the
             spectral lineshapes reflect the airway composition within
             the slice location, according to theory. The peak
             assignments given here also agree with previous studies done
             by Wagshul et al. with HP 129Xe. At each of the slice
             locations, data were acquired during two phases of the
             breathing cycle, resulting in a relative frequency shift of
             approximately 0.3 ppm in the superior slices. Spectra
             obtained over a number of breaths show the dynamics of the
             gas buildup in the lung and provide further evidence
             supporting the peak assignments.},
   Key = {fds269124}
}

@booklet{Staggs98,
   Author = {K. L. Staggs and K. J. Austin and G. A. Johnson and M. G.
             Teixeira and C. T. Talbott and V. A. Dooley and T. R.
             Hansen},
   Title = {Complex induction of bovine uterine proteins by
             interferon-tau},
   Journal = {Biology Of Reproduction},
   Volume = {59},
   Number = {2},
   Pages = {293 -- 297},
   Year = {1998},
   Month = {August},
   Key = {Staggs98}
}

@article{fds132910,
   Author = {KL Staggs and KJ Austin and GA Johnson and MG Teixeira and CT Talbott and VA Dooley and TR Hansen},
   Title = {Complex induction of bovine uterine proteins by
             interferon-tau.},
   Journal = {Biology of reproduction},
   Volume = {59},
   Number = {2},
   Pages = {293-7},
   Year = {1998},
   Month = {August},
   ISSN = {0006-3363},
   Keywords = {Animals • Blotting, Western • Cattle • Cells,
             Cultured • Chemokine CXCL6 • Chemokines, CXC
             • Chromatography, Affinity • Endometrium •
             Epithelial Cells • Estrus • Female •
             Interferon Type I • Interferon Type I, Recombinant
             • Pregnancy • Pregnancy Proteins • Protein
             Biosynthesis* • Stimulation, Chemical • Ubiquitins
             • Uterus • biosynthesis • drug effects •
             metabolism • metabolism* • pharmacology •
             pharmacology* • physiology},
   Abstract = {Interferon-tau (IFN-tau) is released by the conceptus and
             induces two uterine proteins during early pregnancy:
             ubiquitin cross-reactive protein (UCRP) and granulocyte
             chemotactic protein-2 (GCP-2). The present experiments were
             designed to determine whether detection (Western blot) of
             cytosolic UCRP and release of GCP-2 could be used to examine
             IFN-tau signal transduction in cultured endometrial explants
             and primary epithelial cells. Recombinant (r) type 1 IFNs
             (rboIFN-tau and rboIFN-alpha; 5, 25, 100 nM) induced UCRP,
             but only rboIFN-tau induced GCP-2 in explant culture.
             Recombinant boIFN-tau and conceptus secretory proteins
             containing native IFN-tau induced UCRP and GCP-2 in cultured
             primary epithelial cells. All concentrations of rboIFN-alpha
             (25, 50, 100 nM) induced UCRP, but only the highest
             concentration induced GCP-2 in cultured primary epithelial
             cells. Interestingly, phorbol ester (100, 500, 1000 ng/ml)
             induced GCP-2, but it had no effect on UCRP. Because type 1
             IFNs induce UCRP, IFN-tau probably interacts with the janus
             kinase (Jak)-associated IFN-alpha receptor to phosphorylate
             signal transducers and activators of transcription (STAT)
             and/or interferon regulatory factor-1 (IRF-1). However,
             IFN-tau-specific induction of GCP-2 may involve a variant
             type 1 receptor subunit or activators of transcription that
             are associated with protein kinase C and the Jak/STAT/IRF-1
             pathway.},
   Language = {eng},
   Key = {fds132910}
}

@booklet{Chawla98,
   Author = {M. S. Chawla and X. J. Chen and H. E. Moller and G. P. Cofer and C. T. Wheeler and L. W. Hedlund and G. A.
             Johnson},
   Title = {In vivo magnetic resonance vascular imaging using
             laser-polarized He-3 microbubbles},
   Journal = {Proceedings Of The National Academy Of Sciences Of The
             United States Of America},
   Volume = {95},
   Number = {18},
   Pages = {10832 -- 10835},
   Year = {1998},
   Month = {September},
   Key = {Chawla98}
}

@booklet{Locher98,
   Author = {M. Locher and D. Cigna and E. R. Hunt and G. A. Johnson and F. Marchesoni and L. Gammaitoni and M. E. Inchiosa and A. R.
             Bulsara},
   Title = {Stochastic resonance in coupled nonlinear dynamic
             elements},
   Journal = {Chaos},
   Volume = {8},
   Number = {3},
   Pages = {604 -- 615},
   Year = {1998},
   Month = {September},
   Key = {Locher98}
}

@article{fds174073,
   Author = {M Locher and D Cigna and ER Hunt and GA Johnson and F Marchesoni and L
             Gammaitoni, ME Inchiosa and AR Bulsara},
   Title = {Stochastic resonance in coupled nonlinear dynamic
             elements.},
   Journal = {Chaos (Woodbury, N.Y.)},
   Volume = {8},
   Number = {3},
   Pages = {604-615},
   Year = {1998},
   Month = {September},
   ISSN = {1089-7682},
   url = {http://dx.doi.org/10.1063/1.166342},
   Abstract = {We investigate the response of a linear chain of diffusively
             coupled diode resonators under the influence of thermal
             noise. We also examine the connection between spatiotemporal
             stochastic resonance and the presence of kink-antikink pairs
             in the array. The interplay of nucleation rates and kink
             speeds is briefly addressed. The experimental results are
             supplemented with simulations on a coupled map lattice. We
             furthermore present analytical results for the
             synchronization and signal processing properties of a Phi(4)
             field theory and explore the effects of various forms of
             nonlinear coupling. (c) 1998 American Institute of
             Physics.},
   Language = {ENG},
   Doi = {10.1063/1.166342},
   Key = {fds174073}
}

@article{fds269086,
   Author = {Chawla, MS and Chen, XJ and Möller, HE and Cofer, GP and Wheeler, CT and Hedlund, LW and Johnson, GA},
   Title = {In vivo magnetic resonance vascular imaging using
             laser-polarized 3He microbubbles.},
   Journal = {Proceedings of the National Academy of Sciences of
             USA},
   Volume = {95},
   Number = {18},
   Pages = {10832-10835},
   Year = {1998},
   Month = {September},
   ISSN = {0027-8424},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/9724790},
   Keywords = {Angiography • Animals • Helium • Lasers
             • Magnetic Resonance Imaging • Male • Rats
             • Rats, Sprague-Dawley • methods*},
   Abstract = {Laser-polarized gases (3He and 129Xe) are currently being
             used in magnetic resonance imaging as strong signal sources
             that can be safely introduced into the lung. Recently,
             researchers have been investigating other tissues using
             129Xe. These studies use xenon dissolved in a carrier such
             as lipid vesicles or blood. Since helium is much less
             soluble than xenon in these materials, 3He has been used
             exclusively for imaging air spaces. However, considering
             that the signal of 3He is more than 10 times greater than
             that of 129Xe for presently attainable polarization levels,
             this work has focused on generating a method to introduce
             3He into the vascular system. We addressed the low
             solubility issue by producing suspensions of 3He
             microbubbles. Here, we provide the first vascular images
             obtained with laser-polarized 3He. The potential increase in
             signal and absence of background should allow this technique
             to produce high-resolution angiographic images. In addition,
             quantitative measurements of blood flow velocity and tissue
             perfusion will be feasible.},
   Key = {fds269086}
}

@booklet{Moller98,
   Author = {H. E. Moller and X. J. Chen and M. S. Chawla and B. Driehuys and L. W. Hedlund and G. A. Johnson},
   Title = {Signal dynamics in magnetic resonance imaging of the lung
             with hyperpolarized noble gases},
   Journal = {Journal Of Magnetic Resonance},
   Volume = {135},
   Number = {1},
   Pages = {133 -- 143},
   Year = {1998},
   Month = {November},
   Key = {Moller98}
}

@booklet{Todd98a,
   Author = {M. D. Todd and G. A. Johnson and B. A. Althouse and S. T.
             Vohra},
   Title = {Flexural beam-based fiber Bragg grating accelerometers},
   Journal = {Ieee Photonics Technology Letters},
   Volume = {10},
   Number = {11},
   Pages = {1605 -- 1607},
   Year = {1998},
   Month = {November},
   Key = {Todd98a}
}

@booklet{Benveniste98,
   Author = {Benveniste, H and Qui, H and Hedlund, LW and D'Ercole, F and Johnson,
             GA},
   Title = {Spinal cord neural anatomy in rats examined by in vivo
             magnetic resonance microscopy.},
   Journal = {Regional Anesthesia and Pain Medicine},
   Volume = {23},
   Number = {6},
   Pages = {589-599},
   Year = {1998},
   Month = {November},
   ISSN = {1098-7339},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/9840856},
   Abstract = {BACKGROUND AND OBJECTIVES: Magnetic resonance microscopy
             (MRM) is a technique that is worthwhile for
             anesthesiologists because it allows spinal cord and plexus
             anatomy to be visualized three dimensionally and followed
             over time in the same animal. For example, the long-term
             effect of indwelling intrathecal or plexus catheters can be
             studied in situ, and convective and diffusive forces within
             intrathecal, epidural, or nerve sheath spaces can be
             investigated. Further, diffusion-weighted MRM, which
             measures an "apparent diffusion coefficient" (ADC), can be
             used to track the presence of ischemia, hypoperfusion, or
             cytotoxic edema. This study investigates problems associated
             with the use of in vivo MRM for spinal cord and peripheral
             nerve studies in the rat. METHODS: Twenty-one anesthetized
             female Fisher CDF rats were used. Group 1 (n=7) was used for
             anatomic three-dimensional studies. Groups 2 (n=4), 3 (n=4),
             and 4 (n=6) were used for measurements of the ADC. Group 2
             served as controls, group 3 received lumbar intrathecal
             catheters, and group 4 received cervical intrathecal
             catheters. RESULTS: Cervical spine, lumbar spine, and spinal
             nerves and ganglia were accurately visualized with MRM. As a
             rule, spinal cord gray and white matter were better
             demonstrated using diffusion-weighted proton stains. By
             contrast, T2-weighted proton staining superiorly
             demonstrated structures surrounding the spinal cord. In
             groups 3 and 4, indwelling intrathecal catheters did not
             affect the spinal cord ADC, indicating normal blood flow and
             no cytotoxic edema. Contrast studies revealed nonhomogeneous
             distribution of contrast predominately in the lateral and
             ventral intrathecal space. CONCLUSION: Three-dimensional
             diffusion-weighted MRM displays cervical and lumbar spine
             anatomy accurately in vivo. Apparent diffusion coefficients
             measurements are feasible in rat cervical spinal cord with
             intrathecal catheters. Spinal cord ADCs are unaffected by
             intrathecal catheters, indicating normal spinal cord
             perfusion.},
   Key = {Benveniste98}
}

@article{fds269039,
   Author = {Möller, HE and Chen, XJ and Chawla, MS and Driehuys, B and Hedlund, LW and Johnson, GA},
   Title = {Signal dynamics in magnetic resonance imaging of the lung
             with hyperpolarized noble gases.},
   Journal = {Journal of Magnetic Resonance},
   Volume = {135},
   Number = {1},
   Pages = {133-143},
   Year = {1998},
   Month = {November},
   ISSN = {1090-7807},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/9799687},
   Keywords = {Animals • Guinea Pigs • Image Enhancement* •
             Lung • Magnetic Resonance Imaging* • Magnetics
             • Models, Theoretical • Noble Gases •
             Reproducibility of Results • anatomy & histology*
             • diagnostic use* • methods},
   Abstract = {The nonequilibrium bulk magnetic moment of hyperpolarized
             (HP) noble gases generated by optical pumping has unique
             characteristics. Based on the Bloch equations, a model was
             developed describing the signal dynamics of HP gases used in
             magnetic resonance imaging (MRI) of the lung with special
             consideration to the breathing cycle. Experimental
             verification included extensive investigations with HP 3He
             and 129Xe during both inspiration and held breath in live
             guinea pigs. Radial acquisition was used to investigate the
             view variations with a temporal resolution of 5 ms.
             Agreement between theoretical predictions and in vivo
             results was excellent. Additionally, information about
             effects from noble gas diffusion and spin-lattice relaxation
             was obtained. In vivo results for T1 were 28.8 +/- 1.8 s for
             3He and 31.3 +/- 1.8 s for 129Xe. Comparison with in vitro
             data indicated that relaxation in the pulmonary gas space is
             dominated by dipolar coupling with molecular oxygen. The
             results provide a quantitative basis for optimizing pulse
             sequence design in HP gas MRI of the lung.},
   Doi = {10.1006/jmre.1998.1563},
   Key = {fds269039}
}

@booklet{Todd98,
   Author = {M. D. Todd and G. A. Johnson and B. A. Althouse and S. T.
             Vohra},
   Title = {Flexural beam-based fiber Bragg grating accelerometers (vol
             10, pg 1605, 1998)},
   Journal = {Ieee Photonics Technology Letters},
   Volume = {10},
   Number = {12},
   Pages = {1799 -- 1799},
   Year = {1998},
   Month = {December},
   Key = {Todd98}
}

@booklet{Look98,
   Author = {K. Y. Look and J. A. Blessing and B. E. Nelson and G. A.
             Johnson and W. C. Fowler and G. C. Reid},
   Title = {A phase II trial of isotretinoin and alpha interferon in
             patients with recurrent squamous cell carcinoma of the
             cervix - A Gynecologic Oncology Group Study},
   Journal = {American Journal Of Clinical Oncology-cancer Clinical
             Trials},
   Volume = {21},
   Number = {6},
   Pages = {591 -- 594},
   Year = {1998},
   Month = {December},
   Key = {Look98}
}

@article{fds174221,
   Author = {KY Look and JA Blessing and BE Nelson and GA Johnson and WC Fowler Jr and GC Reid},
   Title = {A phase II trial of isotretinoin and alpha interferon in
             patients with recurrent squamous cell carcinoma of the
             cervix: a Gynecologic Oncology Group study.},
   Journal = {American journal of clinical oncology},
   Volume = {21},
   Number = {6},
   Pages = {591-4},
   Year = {1998},
   Month = {December},
   ISSN = {0277-3732},
   Keywords = {Adult • Aged • Antineoplastic Agents •
             Carcinoma, Squamous Cell • Drug Therapy, Combination
             • Female • Humans • Interferon-alpha •
             Isotretinoin • Keratolytic Agents • Middle Aged
             • Neoplasm Recurrence, Local • Uterine Cervical
             Neoplasms • administration & dosage • drug
             therapy* • therapeutic use*},
   Abstract = {From January 1993 through January 1996, 37 patients with
             unresectable squamous carcinoma of the cervix were entered
             on study and scheduled to receive oral isotretinoin 1 mg/kg
             per day with subcutaneous alpha interferon 6,000,000
             units/day. A course was defined as 4 continuous weeks of
             therapy. The mean number of four-course cycles delivered was
             1.8. One patient was ineligible because of wrong cell type
             and two were never treated. Thus, 34 patients were evaluable
             for toxicity. Eight patients were inevaluable for response.
             Five did not receive a complete 4-week course and three did
             not have additional tumor measurements; thus 26 were
             evaluable for response. Prior radiotherapy had been given to
             25 patients and prior chemotherapy to 23 patients. There was
             no grade 4 neutropenia. The incidence of Gynecologic
             Oncology Group (GOG) grade 3 granulocytopenia and
             thrombocytopenia was 8.8% and 5.8%, respectively. Six
             patients (17.6%) developed grade 3 or worse nausea and
             vomiting. Four (11.7%) patients developed grade 3 neurologic
             symptoms. There were no complete responses and one partial
             response. The overall response rate was 3.8% (95% confidence
             interval, 0.1-19.6%). In this pretreated population,
             isotretinoin and alpha interferon in the dose and schedule
             employed exhibit minimal activity.},
   Language = {eng},
   Key = {fds174221}
}

@booklet{Stahl99,
   Author = {L. A. B. Stahl and G. A. Johnson and D. L. Wyse and D. D.
             Buhler and J. L. Gunsolus},
   Title = {Effect of tillage on timing of Setaria spp. emergence and
             growth},
   Journal = {Weed Science},
   Volume = {47},
   Number = {5},
   Pages = {563 -- 570},
   Year = {1999},
   Key = {Stahl99}
}

@article{fds174074,
   Author = {TR Hansen and KJ Austin and DJ Perry and JK Pru and MG Teixeira and GA
             Johnson},
   Title = {Mechanism of action of interferon-tau in the uterus during
             early pregnancy.},
   Journal = {Journal of reproduction and fertility. Supplement},
   Volume = {54},
   Pages = {329-39},
   Year = {1999},
   ISSN = {0449-3087},
   Keywords = {Amino Acid Sequence • Animals • Cattle •
             Chemokine CXCL2 • Chemokine CXCL6 • Chemokines
             • Chemokines, CXC • Corpus Luteum Maintenance
             • Dinoprost • Dinoprostone • Embryo,
             Mammalian • Female • Interferon Type I •
             Molecular Sequence Data • Pregnancy • Pregnancy
             Proteins • Pregnancy, Animal • Progesterone •
             Protein Binding • Receptors, Estradiol •
             Receptors, Interferon • Ubiquitins • genetics
             • metabolism • metabolism* •
             physiology*},
   Abstract = {Early pregnancy is maintained in ruminants through the
             actions of conceptus-derived interferon (IFN)-tau on the
             endometrium. IFN-tau alters uterine release of PGF2 alpha'
             which results in rescue of the corpus luteum and continued
             release of progesterone. The mechanism of action of IFN-tau
             includes inhibition of oestradiol receptors, consequent
             reduction in oxytocin receptors, activation of a
             cyclooxygenase inhibitor, and a shift in the PGs to favour
             PGE2 over PGF2 alpha' IFN-tau also induces several
             endometrial proteins that may be critical for survival of
             the developing embryo. One endometrial protein induced by
             pregnancy and IFN-tau has been identified as bovine
             granulocyte chemotactic protein-2 (bGCP-2). This chemotactic
             cytokine (chemokine) has been used as a marker to delineate
             IFN-tau from IFN-alpha responses in the endometrium. A
             second protein, called ubiquitin cross-reactive protein
             (UCRP), resembles a tandem ubiquitin repeat. UCRP becomes
             conjugated to cytosolic endometrial proteins in response to
             IFN-tau and pregnancy. Proteins conjugated to UCRP are
             either modulated or targeted for processing through the
             proteasome. The action of IFN-tau is mediated by induction
             of signal transducer and activator of transcription 1
             (STAT-1), STAT-2 and interferon regulatory factor 1 (IRF-1)
             transcription factors. Induction of these transcription
             factors, the alpha chemokines and UCRP is the prelude to
             maternal recognition of pregnancy in ruminants.},
   Language = {eng},
   Key = {fds174074}
}

@booklet{Lester99,
   Author = {Lester, DS and Johannessen, JN and Pine, PS and McGregor, GN and Johnson, GA},
   Title = {Virtual neuropathology: A new approach to preclinical
             pathology using magnetic resonance imaging
             microscopy},
   Journal = {Spectroscopy},
   Volume = {14},
   Number = {7},
   Pages = {17-22},
   Year = {1999},
   ISSN = {0887-6703},
   Key = {Lester99}
}

@booklet{Stewart99,
   Author = {M. D. Stewart and G. A. Johnson and A. G. Stagg and R. C.
             Burghardt and L. A. Schuler and F. W. Bazer and T. E.
             Spencer},
   Title = {Prolactin receptor expression in the ovine
             uterus.},
   Journal = {Biology Of Reproduction},
   Volume = {60},
   Pages = {150 -- 150},
   Year = {1999},
   Key = {Stewart99}
}

@booklet{Asselin99,
   Author = {E. Asselin and G. A. Johnson and T. E. Spencer and W. B.
             Fuller},
   Title = {Progesterone and interferon-tau regulate monocyte
             chemotactic protein-1 (MCP-1) in the ovine
             uterus.},
   Journal = {Biology Of Reproduction},
   Volume = {60},
   Pages = {95 -- 95},
   Year = {1999},
   Key = {Asselin99}
}

@booklet{Bazer99,
   Author = {F. W. Bazer and G. A. Johnson and A. G. Stagg and K. M.
             Taylor and E. Gootwine and A. Gertler and T. E.
             Spencer},
   Title = {A servomechanism in the ovine uterus regulates endometrial
             gene expression.},
   Journal = {Biology Of Reproduction},
   Volume = {60},
   Pages = {150 -- 150},
   Year = {1999},
   Key = {Bazer99}
}

@booklet{Johnson99,
   Author = {G. A. Johnson and N. M. Ghoniem},
   Title = {Hierarchical modeling of C and Si nano-cluster nucleation
             utilizing quantum and statistical mechanics},
   Journal = {Journal Of Computer-aided Materials Design},
   Volume = {6},
   Number = {2-3},
   Pages = {337 -- 347},
   Year = {1999},
   Key = {Johnson99}
}

@booklet{Wang99,
   Author = {G. Y. Wang and G. A. Johnson and T. E. Spencer and F. W.
             Bazer},
   Title = {Generation of immortalized porcine uterine cell
             lines.},
   Journal = {Biology Of Reproduction},
   Volume = {60},
   Pages = {260 -- 261},
   Year = {1999},
   Key = {Wang99}
}

@booklet{Johnson99e,
   Author = {G. A. Johnson and T. E. Spencer and R. C. Burghardt and F.
             W. Bazer},
   Title = {Progesterone induces osteopontin expression in ovine
             endometrial glands.},
   Journal = {Biology Of Reproduction},
   Volume = {60},
   Pages = {210 -- 211},
   Year = {1999},
   Key = {Johnson99e}
}

@booklet{Newton99,
   Author = {G. R. Newton and S. Woldesenbet and T. Green and H. Powell and K. Sonnier and G. A. Johnson},
   Title = {H antigen expression by ovine endometrial
             cells.},
   Journal = {Biology Of Reproduction},
   Volume = {60},
   Pages = {120 -- 120},
   Year = {1999},
   Key = {Newton99}
}

@booklet{Hansen99,
   Author = {T. R. Hansen and K. J. Austin and D. J. Perry and J. K. Pru and M. G. Teixeira and G. A. Johnson},
   Title = {Mechanism of action of interferon-tau in the uterus during
             early pregnancy},
   Journal = {Journal Of Reproduction And Fertility},
   Pages = {329 -- 339},
   Year = {1999},
   Key = {Hansen99}
}

@booklet{Spencer99b,
   Author = {T. E. Spencer and G. A. Johnson and R. C. Burghardt and J.
             A. G. W. Fleming and F. W. Bazer},
   Title = {Development and characterization of immortalized ovine
             endometrial cell lines.},
   Journal = {Biology Of Reproduction},
   Volume = {60},
   Pages = {142 -- 142},
   Year = {1999},
   Key = {Spencer99b}
}

@booklet{Miller99,
   Author = {J. R. Miller and S. E. Hurlston and Q. Y. Ma and D. W. Face and D. J. Kountz and J. R. Macfall and L. W. Hedlund and G.
             A. Johnson},
   Title = {Performance of a high-temperature superconducting probe for
             in vivo microscopy at 2.0 T},
   Journal = {Magnetic Resonance In Medicine},
   Volume = {41},
   Number = {1},
   Pages = {72 -- 79},
   Year = {1999},
   Month = {January},
   Key = {Miller99}
}

@booklet{Smith99,
   Author = {Smith, BR and Huff, DS and Johnson, GA},
   Title = {Magnetic resonance imaging of embryos: an Internet resource
             for the study of embryonic development.},
   Journal = {Computerized Medical Imaging and Graphics},
   Volume = {23},
   Number = {1},
   Pages = {33-40},
   Year = {1999},
   Month = {January},
   ISSN = {0895-6111},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10091866},
   Abstract = {The recent amassing of gene expression data to study
             development in mammals has led to an increased demand for
             access to human embryological data. The difficulty of
             obtaining well-preserved human embryos presents an important
             challenge to studying human development. The
             Multidimensional Human Embryo project is generating an image
             data set based on magnetic resonance microscopy of specimens
             from the highly respected Carnegie Collection of Human
             Embryos. The data are available from a web site to
             facilitate the work of clinicians, investigators, and
             students of human development. A consequence of the project
             will be to preserve a highly respected, yet impermanent,
             collection of human embryos and minimize the need for
             collecting new specimens.},
   Key = {Smith99}
}

@article{fds268967,
   Author = {Miller, JR and Hurlston, SE and Ma, QY and Face, DW and Kountz, DJ and MacFall, JR and Hedlund, LW and Johnson, GA},
   Title = {Performance of a high-temperature superconducting probe for
             in vivo microscopy at 2.0 T.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {41},
   Number = {1},
   Pages = {72-79},
   Year = {1999},
   Month = {January},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10025613},
   Keywords = {Animals • Artifacts • Brain • Female •
             Heat* • Image Processing, Computer-Assisted •
             Magnetic Resonance Imaging • Microscopy • Models,
             Theoretical • Rats • Rats, Inbred F344 •
             Thermal Conductivity • anatomy & histology •
             methods* • physiology*},
   Abstract = {The use of a high-temperature superconducting probe for in
             vivo magnetic resonance microscopy at 2 T is described. To
             evaluate the performance of the probe, a series of SNR
             comparisons are carried out. The SNR increased by a factor
             of 3.7 compared with an equivalent copper coil. Quantitative
             measures of the SNR gain are in good agreement with
             theoretical predictions. A number of issues that are unique
             to the application of HTS coils are examined, including the
             difficulty in obtaining homogenous excitation without
             degrading the SNR of the probe. The use of the HTS probe in
             transmit-receive mode is simple to implement but results in
             nonuniform excitation. The effect of using the probe in this
             mode of operation on the T1 and T2 contrast is investigated.
             Methods for improving homogeneity are explored, such as
             employing a transmit volume coil. It is found that the cost
             of using an external transmit coil is an increased probe
             noise temperature and a reduced SNR by approximately 30%.
             Other important aspects of the probe are considered,
             including the effect of temperature on probe stability.
             Three-dimensional in vivo imaging sets are acquired to
             assess the stability of the probe for long scans.
             High-resolution images of the rat brain demonstrate the
             utility of the probe for microscopy applications.},
   Key = {fds268967}
}

@booklet{Spencer99c,
   Author = {T. E. Spencer and F. F. Bartol and F. W. Bazer and G. A.
             Johnson and M. M. Joyce},
   Title = {Identification and characterization of glycosylation-dependent
             cell adhesion molecule 1-like protein expression in the
             ovine uterus},
   Journal = {Biology Of Reproduction},
   Volume = {60},
   Number = {2},
   Pages = {241 -- 250},
   Year = {1999},
   Month = {February},
   Key = {Spencer99c}
}

@article{fds174088,
   Author = {TE Spencer and FF Bartol and FW Bazer and GA Johnson and MM
             Joyce},
   Title = {Identification and characterization of glycosylation-dependent
             cell adhesion molecule 1-like protein expression in the
             ovine uterus.},
   Journal = {Biology of reproduction},
   Volume = {60},
   Number = {2},
   Pages = {241-50},
   Year = {1999},
   Month = {February},
   ISSN = {0006-3363},
   Keywords = {Animals • Blotting, Western • Embryonic
             Development • Endometrium • Epithelium •
             Estrus • Female • Gestational Age •
             Immunosorbent Techniques • Mucins • Myometrium
             • Pregnancy • Sheep • Uterus • analysis*
             • chemistry • chemistry*},
   Abstract = {Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1)
             is an endothelial glycoprotein secreted in lymph nodes that
             serves as a ligand for leukocyte cell surface selectin and
             mediates lymphocyte extravasation. In the present studies,
             rabbit anti-rat GlyCAM-1 IgG was used in immunochemical
             analyses of GlyCAM-1-like protein in the ovine uterus. In
             cyclic ewes, GlyCAM-1 expression increased in the
             endometrial luminal epithelium (LE) and shallow glandular
             epithelium (cGE) between Days 1 and 5 and then decreased
             between Days 11 and 15. In pregnant ewes, GlyCAM-1 in the LE
             and cGE was low on Days 11 and 13, increased on Day 15, and
             was abundant on Days 17 and 19. Immunoreactive GlyCAM-1 was
             also detected in the conceptus trophectoderm on Days 13-19.
             Staining for GlyCAM-1 in the smooth muscle of the
             vasculature and myometrium was constitutive, and no staining
             was detected in the stroma. An immunoreactive protein of
             approximately 45 kDa was identified in endometrial extracts
             and uterine flushings from cyclic and pregnant ewes. In
             pregnant ewes, the relative amount of immunoreactive
             GlyCAM-1 in uterine flushings was low on Days 11 and 13 but
             high on Days 15 and 17. Results suggest that a GlyCAM-1-like
             protein may be a secretory product of the endometrial
             epithelium and/or conceptus trophectoderm. Patterns of
             distribution observed for immunoreactive GlyCAM-1-like
             protein in the endometrial epithelium, combined with
             proposed functions for lymphoid GlyCAM-1, suggest that this
             mucin glycoprotein may be involved in conceptus-maternal
             interactions during the periimplantation period of pregnancy
             in sheep.},
   Language = {eng},
   Key = {fds174088}
}

@article{fds174075,
   Author = {WP Griffin and EB Savage and RE Clark and JJ Pacella and GA Johnson and JA
             Magovern, GJ Magovern Sr},
   Title = {AB-180 circulatory support system: summary of development
             and phase I clinical trial.},
   Journal = {ASAIO journal (American Society for Artificial Internal
             Organs : 1992)},
   Volume = {44},
   Number = {5},
   Pages = {M719-24},
   Year = {1999},
   Month = {February},
   ISSN = {1058-2916},
   Keywords = {Feasibility Studies • Heart-Assist Devices* •
             Humans • Male • Middle Aged • Prosthesis
             Design},
   Abstract = {The AB-180 Circulatory Support System (AB-180 CSS; Cardiac
             Assist Technologies, Pittsburgh, PA) is a left ventricular
             assist system for investigational use in patients with
             postcardiotomy cardiogenic shock who are refractory to
             standard treatment with an intra-aortic balloon pump,
             pharmacologic treatment, or both. The intent of the AB-180
             CSS is to provide temporary (up to 14 days) mechanical
             circulatory support until the heart recovers adequate
             mechanical function. The system consists of a small
             implantable centrifugal pump and a controller. A unique
             infusion system produces a hydrodynamic bearing between
             rotational and stationary components of the AB-180 CSS pump.
             This infusion system also provides a source of heparin for
             localized anticoagulation. Extensive bench and animal work
             has illustrated anticoagulation requirements, established
             operating guidelines, and demonstrated safety and efficacy.
             An investigational device exemption has been granted for a
             Phase I, five patient feasibility study at Allegheny General
             Hospital in Pittsburgh, Pennsylvania. To date, the pump has
             been implanted in one patient. The results from this first
             case are presented here.},
   Language = {eng},
   Key = {fds174075}
}

@booklet{Johnson99g,
   Author = {G. A. Johnson and A. Calkins},
   Title = {Prehospital triage and communication performance in small
             mass casualty incidents: A gauge for disaster
             preparedness},
   Journal = {American Journal Of Emergency Medicine},
   Volume = {17},
   Number = {2},
   Pages = {148 -- 150},
   Year = {1999},
   Month = {March},
   Key = {Johnson99g}
}

@article{fds132794,
   Author = {DS Lester and RC Lyon and GN McGregor and RT Engelhardt and LC Schmued and GA Johnson and JN Johannessen},
   Title = {3-Dimensional visualization of lesions in rat brain using
             magnetic resonance imaging microscopy.},
   Journal = {Neuroreport, ENGLAND},
   Volume = {10},
   Number = {4},
   Pages = {737-41},
   Year = {1999},
   Month = {March},
   ISSN = {0959-4965},
   Keywords = {Animals • Brain • Brain Diseases •
             Histocytochemistry • Image Processing,
             Computer-Assisted • Kainic Acid • Magnetic
             Resonance Imaging • Microscopy • Neurotoxins
             • Rats • analogs & derivatives • chemically
             induced • pathology • pathology* •
             toxicity},
   Abstract = {High-resolution (< 50 microm) magnetic resonance imaging
             microscopy (MRM) has been used to identify brain regions and
             localization of excitotoxin-induced lesions in fixed rat
             brains, subsequently confirmed using standard histology. The
             anatomical extent of lesions identified by MRM was identical
             to that seen in histological sections and various
             histopathological changes could be visualized. In contrast
             to the time involved in preparing and examining histological
             sections, lesions in intact brains could be rapidly
             identified and visualized in three dimensions by examining
             digitally generated sections in any plane. This study shows
             that MRM has tremendous potential as a prescreening tool for
             neurotoxicity and neuropathology. These observations suggest
             that MRM has the potential to affect pathology much as
             conventional MRI has influenced clinical
             imaging.},
   Key = {fds132794}
}

@article{fds174119,
   Author = {GA Johnson and A Calkins},
   Title = {Prehospital triage and communication performance in small
             mass casualty incidents: a gauge for disaster
             preparedness.},
   Journal = {The American journal of emergency medicine},
   Volume = {17},
   Number = {2},
   Pages = {148-50},
   Year = {1999},
   Month = {March},
   ISSN = {0735-6757},
   Keywords = {Accidents, Traffic • Disaster Planning* •
             Emergency Medical Services* • Humans • New York
             • Outcome and Process Assessment (Health Care) •
             Prospective Studies • Quality Control • Relief
             Work* • Retrospective Studies • Triage* •
             Wounds and Injuries • etiology •
             therapy},
   Abstract = {Because of their infrequency, disasters are difficult to
             train for. Emergency prehospital personnel frequently
             participate in small mass casualty incidents (MCIs) (3 to 50
             victims). This study sought to examine prehospital
             performance in small MCIs in areas that are frequently
             mismanaged in disasters. Prospective data from the resource
             physician and retrospective data from tape recorded
             prehospital conversations were collected for a 9-month
             period. Clinical patient data, patient demographics,
             emergency medical services squad characteristics, and triage
             information were recorded. Forty-five consecutive MCIs were
             studied. Most of these were motor vehicle accidents.
             Prehospital providers included paid providers, nonpaid
             providers, and air and ground transport. The mean number of
             victims first identified (4.6%) was greatly different than
             the mean number of victims eventually transported from a
             scene (7.1%). Most patients were treated at a level 1 trauma
             center. Frequent errors included having multiple
             communicators on site (38%), misidentifying the number of
             victims (56%), and having unclear information for the
             resource physician (43%). Only 38% of events had prehospital
             triage information that was deemed appropriate in total.
             These results show that scene and triage errors are frequent
             in MCIs of small scale. This information can be used to
             assay a system's readiness for disasters.},
   Language = {eng},
   Key = {fds174119}
}

@booklet{Lester99a,
   Author = {Lester, DS and Lyon, RC and McGregor, GN and Engelhardt, RT and Schmued,
             LC and Johnson, GA and Johannessen, JN},
   Title = {3-Dimensional visualization of lesions in rat brain using
             magnetic resonance imaging microscopy.},
   Journal = {NeuroReport},
   Volume = {10},
   Number = {4},
   Pages = {737-741},
   Year = {1999},
   Month = {March},
   ISSN = {0959-4965},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10208540},
   Abstract = {High-resolution (< 50 microm) magnetic resonance imaging
             microscopy (MRM) has been used to identify brain regions and
             localization of excitotoxin-induced lesions in fixed rat
             brains, subsequently confirmed using standard histology. The
             anatomical extent of lesions identified by MRM was identical
             to that seen in histological sections and various
             histopathological changes could be visualized. In contrast
             to the time involved in preparing and examining histological
             sections, lesions in intact brains could be rapidly
             identified and visualized in three dimensions by examining
             digitally generated sections in any plane. This study shows
             that MRM has tremendous potential as a prescreening tool for
             neurotoxicity and neuropathology. These observations suggest
             that MRM has the potential to affect pathology much as
             conventional MRI has influenced clinical
             imaging.},
   Key = {Lester99a}
}

@booklet{Viallon99,
   Author = {M. Viallon and G. P. Cofer and S. A. Suddarth and H. E.
             Moller and X. J. Chen and M. S. Chawla and L. W. Hedlund and Y. Cremillieux and G. A. Johnson},
   Title = {Functional MR microscopy of the lung using hyperpolarized
             He-3},
   Journal = {Magnetic Resonance In Medicine},
   Volume = {41},
   Number = {4},
   Pages = {787 -- 792},
   Year = {1999},
   Month = {April},
   Key = {Viallon99}
}

@booklet{Moller99,
   Author = {Möller, HE and Chen, XJ and Chawla, MS and Cofer, GP and Driehuys, B and Hedlund, LW and Suddarth, SA and Johnson, GA},
   Title = {Sensitivity and resolution in 3D NMR microscopy of the lung
             with hyperpolarized noble gases.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {41},
   Number = {4},
   Pages = {800-808},
   Year = {1999},
   Month = {April},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10332857},
   Abstract = {Three-dimensional magnetic resonance images of the guinea
             pig lung were acquired in vivo using hyperpolarized (HP)
             noble gases and radial projection encoding (PE). Results
             obtained with 3He (voxel size 17 microl) demonstrated high
             image quality showing airway structure down to the 5th or
             6th generations. Signal-to-noise ratios (SNRs) of 129Xe
             images (voxel size 40 microl) were lower by about 1 order of
             magnitude as a consequence of the smaller gyromagnetic
             ratio, a more rapid relaxation in the gas reservoir, and
             lower polarization and isotope abundance. Comparison between
             experimentally obtained SNRs and results from calculations
             based on a model that accounts for the three-dimensional PE
             acquisition scheme and the non-equilibrium situation in HP
             gas imaging yielded excellent agreement for small flip
             angles. A theoretical examination of the potential
             resolution in HP gas MR microscopy of the lungs suggests
             that in vivo visualization of alveolar clusters distal to
             respiratory bronchioles may be possible.},
   Key = {Moller99}
}

@article{fds132779,
   Author = {HE Möller and XJ Chen and MS Chawla and GP Cofer and B Driehuys and LW
             Hedlund, SA Suddarth and GA Johnson},
   Title = {Sensitivity and resolution in 3D NMR microscopy of the lung
             with hyperpolarized noble gases.},
   Journal = {Magnetic resonance in medicine : official journal of the
             Society of Magnetic Resonance in Medicine / Society of
             Magnetic Resonance in Medicine, UNITED STATES},
   Volume = {41},
   Number = {4},
   Pages = {800-8},
   Year = {1999},
   Month = {April},
   ISSN = {0740-3194},
   Keywords = {Animals • Guinea Pigs • Lung • Magnetic
             Resonance Imaging • Microscopy • Models,
             Theoretical • Noble Gases • Sensitivity and
             Specificity • cytology* • diagnostic use* •
             methods*},
   Abstract = {Three-dimensional magnetic resonance images of the guinea
             pig lung were acquired in vivo using hyperpolarized (HP)
             noble gases and radial projection encoding (PE). Results
             obtained with 3He (voxel size 17 microl) demonstrated high
             image quality showing airway structure down to the 5th or
             6th generations. Signal-to-noise ratios (SNRs) of 129Xe
             images (voxel size 40 microl) were lower by about 1 order of
             magnitude as a consequence of the smaller gyromagnetic
             ratio, a more rapid relaxation in the gas reservoir, and
             lower polarization and isotope abundance. Comparison between
             experimentally obtained SNRs and results from calculations
             based on a model that accounts for the three-dimensional PE
             acquisition scheme and the non-equilibrium situation in HP
             gas imaging yielded excellent agreement for small flip
             angles. A theoretical examination of the potential
             resolution in HP gas MR microscopy of the lungs suggests
             that in vivo visualization of alveolar clusters distal to
             respiratory bronchioles may be possible.},
   Key = {fds132779}
}

@article{fds268976,
   Author = {Viallon, M and Cofer, GP and Suddarth, SA and Möller, HE and Chen, XJ and Chawla, MS and Hedlund, LW and Crémillieux, Y and Johnson,
             GA},
   Title = {Functional MR microscopy of the lung using hyperpolarized
             3He.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {41},
   Number = {4},
   Pages = {787-792},
   Year = {1999},
   Month = {April},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10332855},
   Keywords = {Animals • Guinea Pigs • Helium • Isotopes
             • Lung • Magnetic Resonance Imaging, Cine •
             Microscopy • cytology • diagnostic use* •
             methods • methods* • physiology*},
   Abstract = {A new strategy designed to provide functional magnetic
             resonance images of the lung in small animals at microscopic
             resolution using hyperpolarized 3He is described. The pulse
             sequence is based on a combination of radial acquisition
             (RA) and CINE techniques, referred to as RA-CINE, and is
             designed for use with hyperpolarized 3He to explore lung
             ventilation with high temporal and spatial resolution in
             small animal models. Ventilation of the live guinea pig is
             demonstrated with effective temporal resolution of 50 msec
             and in-plane spatial resolution of <100 microm using
             hyperpolarized 3He. The RA-CINE sequence allows one to
             follow gas inflow and outflow in the airways as well as in
             the distal part of the lungs. Regional analysis of signal
             intensity variations can be performed and can help assess
             functional lung parameters such as residual gas volume and
             lung compliance to gas inflow.},
   Key = {fds268976}
}

@booklet{Moller99a,
   Author = {H. E. Moller and M. S. Chawla and X. J. Chen and B. Driehuys and L. W. Hedlund and C. T. Wheeler and G. A.
             Johnson},
   Title = {Magnetic resonance angiography with hyperpolarized Xe-129
             dissolved in a lipid emulsion},
   Journal = {Magnetic Resonance In Medicine},
   Volume = {41},
   Number = {5},
   Pages = {1058 -- 1064},
   Year = {1999},
   Month = {May},
   Key = {Moller99a}
}

@booklet{Hurlston99,
   Author = {Hurlston, SE and Brey, WW and Suddarth, SA and Johnson,
             GA},
   Title = {A high-temperature superconducting Helmholtz probe for
             microscopy at 9.4 T.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {41},
   Number = {5},
   Pages = {1032-1038},
   Year = {1999},
   Month = {May},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10332887},
   Abstract = {The design and operation of a high-temperature
             superconducting (HTS) probe for magnetic resonance
             microscopy (MRM) at 400 MHz are presented. The design of the
             probe includes a Helmholtz coil configuration and a stable
             open-cycle cooling mechanism. Characterization of coil
             operating parameters is presented to demonstrate the
             suitability of cryo-cooled coils for MRM. Specifically, the
             performance of the probe is evaluated by comparison of
             signal-to-noise (SNR) performance with that of a copper
             Helmholtz pair, analysis of B1 field homogeneity, and
             quantification of thermal stability. Images are presented to
             demonstrate the SNR advantage of the probe for typical MRM
             applications.},
   Key = {Hurlston99}
}

@article{fds132839,
   Author = {SE Hurlston and WW Brey and SA Suddarth and GA Johnson},
   Title = {A high-temperature superconducting Helmholtz probe for
             microscopy at 9.4 T.},
   Journal = {Magnetic resonance in medicine : official journal of the
             Society of Magnetic Resonance in Medicine / Society of
             Magnetic Resonance in Medicine, UNITED STATES},
   Volume = {41},
   Number = {5},
   Pages = {1032-8},
   Year = {1999},
   Month = {May},
   ISSN = {0740-3194},
   Keywords = {Algorithms • Aluminum Oxide • Animals •
             Artifacts • Cold • Copper • Equipment Design
             • Heat • Helium • Image Processing,
             Computer-Assisted • Magnetic Resonance Imaging •
             Mice • Microscopy • Phantoms, Imaging • Radio
             Waves • Ruthenium Compounds • Sensitivity and
             Specificity • Signal Processing, Computer-Assisted
             • Thermal Conductivity • instrumentation •
             instrumentation*},
   Abstract = {The design and operation of a high-temperature
             superconducting (HTS) probe for magnetic resonance
             microscopy (MRM) at 400 MHz are presented. The design of the
             probe includes a Helmholtz coil configuration and a stable
             open-cycle cooling mechanism. Characterization of coil
             operating parameters is presented to demonstrate the
             suitability of cryo-cooled coils for MRM. Specifically, the
             performance of the probe is evaluated by comparison of
             signal-to-noise (SNR) performance with that of a copper
             Helmholtz pair, analysis of B1 field homogeneity, and
             quantification of thermal stability. Images are presented to
             demonstrate the SNR advantage of the probe for typical MRM
             applications.},
   Key = {fds132839}
}

@article{fds269032,
   Author = {Möller, HE and Chawla, MS and Chen, XJ and Driehuys, B and Hedlund, LW and Wheeler, CT and Johnson, GA},
   Title = {Magnetic resonance angiography with hyperpolarized 129Xe
             dissolved in a lipid emulsion.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {41},
   Number = {5},
   Pages = {1058-1064},
   Year = {1999},
   Month = {May},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10332890},
   Keywords = {Abdomen • Animals • Artifacts • Blood Flow
             Velocity • Blood Volume • Contrast Media* •
             Electron Spin Resonance Spectroscopy • Fat Emulsions,
             Intravenous • Iliac Vein • Injections, Intravenous
             • Lasers • Magnetic Resonance Angiography •
             Magnetic Resonance Spectroscopy • Male • Pelvis
             • Rats • Renal Veins • Signal Processing,
             Computer-Assisted • Veins • Vena Cava, Inferior
             • Xenon Isotopes* • administration & dosage •
             anatomy & histology • blood supply • diagnostic
             use* • methods*},
   Abstract = {Hyperpolarized (HP) 129Xe can be dissolved in biologically
             compatible lipid emulsions while maintaining sufficient
             polarization for in vivo vascular imaging. For xenon in
             Intralipid 30%, in vitro spectroscopy at 2 T yielded a
             chemical shift of 197 +/- 1 ppm with reference to xenon gas,
             a spin-lattice relaxation time T1 = 25.3 +/- 2.1 sec, and a
             T2* time constant of 37 +/- 5 msec. Angiograms of the
             abdominal and pelvic veins in the rat obtained with 129Xe
             MRI after intravenous injection of HP 129Xe/Intralipid 30%
             into the tail demonstrated signal-to-noise ratios between 8
             and 29. An analysis of the inflow effect on time-of-flight
             images of two segments of the inferior vena cava yielded
             additional information. The mean blood flow velocity was
             34.7 +/- 1.0 mm/sec between the junction of the caudal veins
             and the kidneys and 13.3 +/- 0.8 mm/sec at the position of
             the diaphragm. The mean volume flow rates in these segments
             were 7.2 +/- 3.4 ml/min and 11.0 +/- 2.8 ml/min,
             respectively. Intravenous delivery of HP 129Xe dissolved in
             a carrier may lead to novel biomedical applications of
             laser-polarized gases.},
   Key = {fds269032}
}

@booklet{Johnson99d,
   Author = {G. A. Johnson and K. J. Austin and A. M. Collins and W. J.
             Murdoch and T. R. Hansen},
   Title = {Endometrial ISG17 mRNA and a related mRNA are induced by
             interferon-tau and localized to glandular epithelial and
             stromal cells from pregnant cows},
   Journal = {Endocrine},
   Volume = {10},
   Number = {3},
   Pages = {243 -- 252},
   Year = {1999},
   Month = {June},
   Key = {Johnson99d}
}

@article{fds174237,
   Author = {GA Johnson and KJ Austin and AM Collins and WJ Murdoch and TR
             Hansen},
   Title = {Endometrial ISG17 mRNA and a related mRNA are induced by
             interferon-tau and localized to glandular epithelial and
             stromal cells from pregnant cows.},
   Journal = {Endocrine},
   Volume = {10},
   Number = {3},
   Pages = {243-52},
   Year = {1999},
   Month = {June},
   ISSN = {1355-008X},
   url = {http://dx.doi.org/10.1007/BF02738623},
   Keywords = {Animals • Blotting, Northern • Cattle • Cell
             Line • Endometrium • Epithelial Cells •
             Female • In Situ Hybridization • Interferon Type I
             • Nuclear Proteins • Pregnancy • Pregnancy
             Proteins • RNA, Messenger • Recombinant Proteins
             • Stromal Cells • Tissue Distribution •
             analysis • biosynthesis* • chemistry •
             genetics* • metabolism* • pharmacology •
             pharmacology*},
   Abstract = {The interferon stimulated gene product, ISG17, conjugates to
             bovine uterine proteins in response to conceptus-derived
             interferon (IFN)-tau. The objectives of the present
             experiments were to examine induction of ISG17 (0.65 kb) and
             a related 2.5 kb mRNA in response to IFN-tau and pregnancy
             using Northern blotting procedures, and to determine cell
             types in the endometrium that expressed ISG17 mRNA using in
             situ hybridization. RNA was isolated from endometrial
             explants or from bovine endometrial (BEND) cells cultured in
             the absence (control) or presence of 25 nM recombinant (r)
             bolFN-tau for 0, 3, 6, 12, 24, or 48 h. The major ISG17 0.65
             kb mRNA and a minor 2.5 kb mRNA were induced (p<0.05) after
             6 h (explants) or 3 h (BEND cells) treatment with
             rboIFN-tau. Both mRNAs were present in endometrium from day
             18 pregnant cows, but were absent in endometrium from
             nonpregnant cows. The ISG17 mRNA was localized to stromal
             and glandular epithelial cells on d 18 of pregnancy. The 2.5
             kb mRNA may encode a novel ISG17 homolog, or a unique
             polyISG17 repeat that is similar in structure to the
             polyubiquitin genes. Because ISG17 mRNA is induced in
             stromal and glandular epithelial cells, it could be assumed
             that ISG17 has a role in regulating intracellular proteins
             in both cell types.},
   Language = {eng},
   Doi = {10.1007/BF02738623},
   Key = {fds174237}
}

@booklet{Johnson99f,
   Author = {G. A. Johnson and T. E. Spencer and T. R. Hansen and K. J.
             Austin and R. C. Burghardt and F. W. Bazer},
   Title = {Expression of the interferon tau inducible ubiquitin
             cross-reactive protein in the ovine uterus},
   Journal = {Biology Of Reproduction},
   Volume = {61},
   Number = {1},
   Pages = {312 -- 318},
   Year = {1999},
   Month = {July},
   Key = {Johnson99f}
}

@booklet{Benveniste99a,
   Author = {Benveniste, H and Qui, H and Hedlund, LW and Hüttemeier, PC and Steele,
             SM and Johnson, GA},
   Title = {In vivo diffusion-weighted magnetic resonance microscopy of
             rat spinal cord: effect of ischemia and intrathecal
             hyperbaric 5% lidocaine.},
   Journal = {Regional Anesthesia and Pain Medicine},
   Volume = {24},
   Number = {4},
   Pages = {311-318},
   Year = {1999},
   Month = {July},
   ISSN = {1098-7339},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10445769},
   Abstract = {BACKGROUND AND OBJECTIVES: Pathophysiologic mechanisms
             underlying persistent neurologic deficits after continuous
             spinal anesthesia using hyperbaric 5% lidocaine are still
             not well understood. It has been suggested that high-dose
             intrathecal lidocaine induces irreversible conduction block
             and even ischemia in white matter tracts by breakdown of the
             blood-nerve barrier. In this study, we use
             diffusion-weighted magnetic resonance microscopy to
             characterize the effect of intrathecal hyperbaric 5%
             lidocaine in rat spinal cord. The parameter measured with
             DWM, is an "apparent diffusion coefficient," (ADC), which
             can be used to exclude the presence of ischemia. METHODS:
             Female Fischer CDF rats were used. Group 1 (n = 5) was
             exposed to ischemia, group 2 (n = 7) was exposed to
             intrathecal 5% hyperbaric lidocaine, and group 3 (n = 5) was
             exposed to intrathecal 7.5% glucose. Diffusion-weighted MR
             images in group 1 were acquired before and after ischemia
             induced by cardiac arrest and in groups 2 and 3 rats prior
             to and during perfusion of the spinal catheter with either
             5% hyperbaric lidocaine or 7.5% glucose. RESULTS: Ischemia
             decreased the ADC by 40% in gray matter and by 30% in white
             matter of spinal cord. Continuous intrathecal anesthesia
             with hyperbaric 5% lidocaine did not affect the spinal cord
             ADC. Further, 7.5% intrathecal glucose had no effect on ADCs
             in gray or white matter of spinal cord. CONCLUSIONS:
             Ischemia reduced the ADC in both spinal cord white and gray
             matter. Hyperbaric 5% lidocaine did not affect the spinal
             cord ADC during the first 1.5 hours. We suggest that 5%
             hyperbaric lidocaine does not induce irreversible neurologic
             deficits by causing spinal cord ischemia.},
   Key = {Benveniste99a}
}

@article{fds174235,
   Author = {GA Johnson and TE Spencer and TR Hansen and KJ Austin and RC Burghardt and FW Bazer},
   Title = {Expression of the interferon tau inducible ubiquitin
             cross-reactive protein in the ovine uterus.},
   Journal = {Biology of reproduction},
   Volume = {61},
   Number = {1},
   Pages = {312-8},
   Year = {1999},
   Month = {July},
   ISSN = {0006-3363},
   Keywords = {Animals • Blotting, Northern • Blotting, Western
             • Cattle • Endometrium • Epithelium •
             Female • Gene Expression Regulation* • Gestational
             Age • In Situ Hybridization • Interferon Type I
             • Ovariectomy • Pregnancy • Pregnancy
             Proteins • RNA, Messenger • Recombinant Proteins
             • Sheep* • Stromal Cells • Ubiquitins •
             Uterus • analogs & derivatives* • analysis •
             chemistry • genetics • metabolism* •
             pharmacology • pharmacology*},
   Abstract = {Ubiquitin cross-reactive protein (UCRP) is a 17-kDa protein
             that shows cross-reactivity with ubiquitin antisera and
             retains the carboxyl-terminal Leu-Arg-Gly-Gly amino acid
             sequence of ubiquitin that ligates to, and directs
             degradation of, cytosolic proteins. It has been reported
             that bovine endometrial UCRP is synthesized and secreted in
             response to conceptus-derived interferon-tau (IFNtau). In
             the present studies, UCRP mRNA and protein were detected in
             ovine endometrium. Ovine UCRP mRNA was detectable on Day 13,
             peaked at Day 15, and remained high through Day 19 of
             pregnancy. The UCRP mRNA was localized to the luminal
             epithelium (LE), stromal cells (ST) immediately beneath the
             LE, and shallow glandular epithelium (GE) on Day 13, but it
             extended to the deep GE, deep ST, and myometrium of uterine
             tissues by Day 15 of pregnancy. Western blotting revealed
             induction of UCRP in the endometrial extracts from pregnant,
             but not cyclic, ewes. Ovine UCRP was also detected in
             uterine flushings from Days 15 and 17 of pregnancy and
             immunoprecipitated from Day 17 pregnant endometrial
             explant-conditioned medium. Treatment of immortalized ovine
             LE cells with recombinant ovine (ro) IFNtau induced
             cytosolic expression of UCRP, and intrauterine injection of
             roIFNtau into ovariectomized cyclic ewes induced endometrial
             expression of UCRP mRNA. These results are the first to
             describe temporal and spatial alterations in the cellular
             localization of UCRP in the ruminant uterus. Collectively,
             UCRP is synthesized and secreted by the ovine endometrium in
             response to IFNtau during early pregnancy. Because UCRP is
             present in the uterus and uterine flushings, it may regulate
             endometrial proteins associated with establishment and
             maintenance of early pregnancy in ruminants.},
   Language = {eng},
   Key = {fds174235}
}

@booklet{Spencer99a,
   Author = {T. E. Spencer and A. G. Stagg and T. L. Ott and G. A.
             Johnson and W. S. Ramsey and F. W. Bazer},
   Title = {Differential effects of intrauterine and subcutaneous
             administration of recombinant ovine interferon tau on the
             endometrium of cyclic ewes},
   Journal = {Biology Of Reproduction},
   Volume = {61},
   Number = {2},
   Pages = {464 -- 470},
   Year = {1999},
   Month = {August},
   Key = {Spencer99a}
}

@article{fds174157,
   Author = {TE Spencer and AG Stagg and TL Ott and GA Johnson and WS Ramsey and FW
             Bazer},
   Title = {Differential effects of intrauterine and subcutaneous
             administration of recombinant ovine interferon tau on the
             endometrium of cyclic ewes.},
   Journal = {Biology of reproduction},
   Volume = {61},
   Number = {2},
   Pages = {464-70},
   Year = {1999},
   Month = {August},
   ISSN = {0006-3363},
   Keywords = {Animals • Antiviral Agents • Carrier Proteins
             • Endometrium • Female • GTP
             Phosphohydrolases • GTP-Binding Proteins • Gene
             Expression Regulation, Developmental • In Situ
             Hybridization • Injections, Subcutaneous •
             Interferon Type I • Leucine Zippers • Pregnancy
             • Pregnancy Proteins • Protein Biosynthesis •
             Proteins • Receptors, Estrogen • Receptors,
             Oxytocin • Recombinant Proteins • Sheep •
             Ubiquitins • Uterus • administration & dosage
             • administration & dosage* • analogs & derivatives
             • biosynthesis • drug effects* • genetics
             • pharmacology • pharmacology*},
   Abstract = {Interferon tau (IFNtau) is the antiluteolytic signal
             produced by the conceptus of ruminants. Intrauterine
             administration of recombinant ovine IFNtau suppresses
             expression of endometrial estrogen receptor (ER) and
             oxytocin receptor (OTR) in the luminal and superficial
             glandular epithelia to abrogate the production of luteolytic
             prostaglandin F(2alpha) (PGF(2alpha)) pulses. Subcutaneous
             (s.c.) injections of recombinant ovine (o) IFNtau appear to
             extend the interestrous interval by altering uterine
             PGF(2alpha) response to oxytocin. The present study tested
             the hypothesis that antiluteolytic effects of roIFNtau
             injected into the uterine lumen (paracrine) or s.c.
             (endocrine) are equivalent in suppressing expression of
             endometrial ER and OTR and inducing uterine expression of
             type I IFN-regulated Mx and ubiquitin cross-reactive
             proteins (UCRP). Sixteen cyclic ewes were fitted with
             uterine catheters on Day 5 (Day 0 = estrus), were assigned
             randomly to receive treatment with control proteins or
             roIFNtau (2 x 10(7) antiviral units/day) by either
             intrauterine or s.c. injections from Days 11 to 15, and were
             ovariohysterectomized on Day 16. Results indicated that
             expression of ER and OTR mRNAs in endometrial epithelium was
             suppressed by intrauterine but not by s.c. injections of
             roIFNtau. Intrauterine injections of roIFNtau increased
             expression of Mx and UCRP mRNA in the endometrium.
             Subcutaneous injections of roIFNtau increased endometrial Mx
             mRNA levels but not UCRP mRNA. Unexpectedly, intrauterine
             and s.c. injections of roIFNtau were equally effective in
             inducing expression of Mx and UCRP mRNA in the corpus
             luteum. Although s.c. injections of roIFNtau induced Mx mRNA
             in the endometrial epithelium, s.c. injections of roIFNtau
             did not abrogate activation of the uterine luteolytic
             mechanism by suppressing epithelial ER and OTR expression.
             Therefore, results of this study failed to support the
             assumption that endocrine roIFNtau mimics antiluteolytic
             effects of paracrine IFNtau to improve pregnancy rates in
             sheep.},
   Language = {eng},
   Key = {fds174157}
}

@booklet{Benveniste99,
   Author = {Benveniste, HD and Kim, KR and Hedlund, LW and Johnson, GA and Friedman,
             AH},
   Title = {Cerebral hemorrhage and edema following brain biopsy in
             rats: Significance of mean arterial blood
             pressure},
   Journal = {Anesthesiology},
   Volume = {91},
   Number = {3A},
   Pages = {U371-U371},
   Year = {1999},
   Month = {September},
   ISSN = {0003-3022},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000082480600839&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Benveniste99}
}

@booklet{Johnson99c,
   Author = {G. A. Johnson and R. C. Burghardt and T. E. Spencer and G.
             C. R. Newton and T. L. Ott and F. W. Bazer},
   Title = {Ovine osteopontin: II. Osteopontin and alpha(v)beta(3)
             integrin expression in the uterus and conceptus during the
             periimplantation period},
   Journal = {Biology Of Reproduction},
   Volume = {61},
   Number = {4},
   Pages = {892 -- 899},
   Year = {1999},
   Month = {October},
   Key = {Johnson99c}
}

@booklet{Todd99,
   Author = {M. D. Todd and G. A. Johnson and C. C. Chang},
   Title = {Passive, light intensity-independent interferometric method
             for fibre Bragg grating interrogation},
   Journal = {Electronics Letters},
   Volume = {35},
   Number = {22},
   Pages = {1970 -- 1971},
   Year = {1999},
   Month = {October},
   Key = {Todd99}
}

@booklet{Johnson99b,
   Author = {G. A. Johnson and T. E. Spencer and R. C. Burghardt and F.
             W. Bazer},
   Title = {Ovine osteopontin: I. Cloning and expression of messenger
             ribonucleic acid in the uterus during the periimplantation
             period},
   Journal = {Biology Of Reproduction},
   Volume = {61},
   Number = {4},
   Pages = {884 -- 891},
   Year = {1999},
   Month = {October},
   Key = {Johnson99b}
}

@booklet{Chen99a,
   Author = {X. J. Chen and H. E. Moller and M. S. Chawla and G. P. Cofer and B. Driehuys and L. W. Hedlund and J. R. Macfall and G.
             A. Johnson},
   Title = {Spatially resolved measurements of hyperpolarized gas
             properties in the lung in vivo. Part II:
             T-2*},
   Journal = {Magnetic Resonance In Medicine},
   Volume = {42},
   Number = {4},
   Pages = {729 -- 737},
   Year = {1999},
   Month = {October},
   Key = {Chen99a}
}

@booklet{Chen99,
   Author = {Chen, XJ and Möller, HE and Chawla, MS and Cofer, GP and Driehuys, B and Hedlund, LW and Johnson, GA},
   Title = {Spatially resolved measurements of hyperpolarized gas
             properties in the lung in vivo. Part I: diffusion
             coefficient.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {42},
   Number = {4},
   Pages = {721-728},
   Year = {1999},
   Month = {October},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10502761},
   Abstract = {In imaging of hyperpolarized noble gases, a knowledge of the
             diffusion coefficient (D) is important both as a contrast
             mechanism and in the design of pulse sequences. We have made
             diffusion coefficient maps of both hyperpolarized (3)He and
             (129)Xe in guinea pig lungs. Along the length of the
             trachea, (3)He D values were on average 2.4 cm(2)/sec,
             closely reproducing calculated values for free gas (2.05
             cm(2)/sec). The (3)He D values measured perpendicular to the
             length of the trachea were approximately a factor of two
             less, indicating restriction to diffusion. Further evidence
             of restricted diffusion was seen in the distal pulmonary
             airspaces as the average (3)He D was 0.16 cm(2)/sec. An
             additional cause for the smaller (3)He D in the lung was due
             to the presence of air, which is composed of heavier and
             larger gases. The (129)Xe results show similar trends, with
             the trachea D averaging 0.068 cm(2)/sec and the lung D
             averaging 0.021 cm(2)/sec. Magn Reson Med 42:721-728,
             1999.},
   Key = {Chen99}
}

@article{fds132869,
   Author = {XJ Chen and HE Möller and MS Chawla and GP Cofer and B Driehuys and LW
             Hedlund, GA Johnson},
   Title = {Spatially resolved measurements of hyperpolarized gas
             properties in the lung in vivo. Part I: diffusion
             coefficient.},
   Journal = {Magnetic resonance in medicine : official journal of the
             Society of Magnetic Resonance in Medicine / Society of
             Magnetic Resonance in Medicine, UNITED STATES},
   Volume = {42},
   Number = {4},
   Pages = {721-8},
   Year = {1999},
   Month = {October},
   ISSN = {0740-3194},
   Keywords = {Animals • Guinea Pigs • Helium • Isotopes
             • Lung • Magnetic Resonance Imaging •
             Pulmonary Diffusing Capacity • Xenon Isotopes •
             anatomy & histology* • diagnostic use •
             methods*},
   Abstract = {In imaging of hyperpolarized noble gases, a knowledge of the
             diffusion coefficient (D) is important both as a contrast
             mechanism and in the design of pulse sequences. We have made
             diffusion coefficient maps of both hyperpolarized (3)He and
             (129)Xe in guinea pig lungs. Along the length of the
             trachea, (3)He D values were on average 2.4 cm(2)/sec,
             closely reproducing calculated values for free gas (2.05
             cm(2)/sec). The (3)He D values measured perpendicular to the
             length of the trachea were approximately a factor of two
             less, indicating restriction to diffusion. Further evidence
             of restricted diffusion was seen in the distal pulmonary
             airspaces as the average (3)He D was 0.16 cm(2)/sec. An
             additional cause for the smaller (3)He D in the lung was due
             to the presence of air, which is composed of heavier and
             larger gases. The (129)Xe results show similar trends, with
             the trachea D averaging 0.068 cm(2)/sec and the lung D
             averaging 0.021 cm(2)/sec. Magn Reson Med 42:721-728,
             1999.},
   Key = {fds132869}
}

@article{fds174150,
   Author = {GA Johnson and TE Spencer and RC Burghardt and FW
             Bazer},
   Title = {Ovine osteopontin: I. Cloning and expression of messenger
             ribonucleic acid in the uterus during the periimplantation
             period.},
   Journal = {Biology of reproduction},
   Volume = {61},
   Number = {4},
   Pages = {884-91},
   Year = {1999},
   Month = {October},
   ISSN = {0006-3363},
   Keywords = {Amino Acid Sequence • Animals • Base Sequence
             • Blotting, Western • Cloning, Molecular •
             Embryonic Development • Estrus • Female •
             Gene Expression Regulation, Developmental* • In Situ
             Hybridization • Molecular Sequence Data •
             Osteopontin • Pregnancy • Pregnancy, Animal •
             RNA, Messenger • Sheep • Sialoglycoproteins •
             Time Factors • Uterus • biosynthesis •
             biosynthesis* • genetics* • metabolism* •
             physiology • veterinary},
   Abstract = {Trophoblast-derived interferon tau (IFNtau) acts on the
             endometrium to increase secretion of several proteins during
             the pregnancy recognition period in ruminants. One of these
             is a 70-kDa acidic protein that has not been identified. Our
             hypothesis was that the 70-kDa acidic protein is osteopontin
             (OPN). OPN is an acidic glycoprotein that fragments upon
             freezing and thawing or treatment with proteases including
             thrombin. OPN contains a Gly-Arg-Gly-Asp-Ser (GRGDS)
             sequence that binds to cell surface integrins to promote
             cell-cell attachment and cell spreading. Using antisera to
             recombinant human OPN, both 70-kDa and 45-kDa proteins were
             identified in uterine flushings from pregnant ewes by
             Western blotting. A clone containing the entire ovine OPN
             cDNA coding sequence was isolated by screening a Day 15
             pregnant ovine endometrial cDNA library with a partial ovine
             OPN cDNA. In pregnant ewes, steady-state levels of OPN
             endometrial mRNA increased (P < 0. 01) after Day 17. In both
             cyclic and pregnant ewes, in situ hybridization analysis
             showed that OPN mRNA was localized on unidentified immune
             cells within the stratum compactum of the endometrium. In
             pregnant ewes, OPN mRNA was also expressed by the glandular
             epithelium. Results suggest that progesterone and/or IFNtau
             induce expression and secretion of OPN by uterine glands
             during the periimplantation period and that OPN may induce
             adhesion between luminal epithelium and trophectoderm to
             facilitate superficial implantation.},
   Language = {eng},
   Key = {fds174150}
}

@article{fds174167,
   Author = {GA Johnson and RC Burghardt and TE Spencer and GR Newton and TL Ott and FW
             Bazer},
   Title = {Ovine osteopontin: II. Osteopontin and alpha(v)beta(3)
             integrin expression in the uterus and conceptus during the
             periimplantation period.},
   Journal = {Biology of reproduction},
   Volume = {61},
   Number = {4},
   Pages = {892-9},
   Year = {1999},
   Month = {October},
   ISSN = {0006-3363},
   Keywords = {Animals • Blotting, Western • Culture Media,
             Conditioned • Culture Techniques •
             Electrophoresis, Polyacrylamide Gel • Embryo, Mammalian
             • Embryonic Development* • Endometrium •
             Female • Osteopontin • Pregnancy • Pregnancy,
             Animal • Receptors, Vitronectin • Sheep •
             Sialoglycoproteins • Time Factors • Uterus •
             biosynthesis* • metabolism • metabolism* •
             veterinary},
   Abstract = {Osteopontin (OPN) is an acidic 70-kDa glycoprotein that is
             cleaved by proteases to yield 45-kDa and 24-kDa fragments.
             The 70-kDa and 45-kDa proteins contain a Gly-Arg-Gly-Asp-Ser
             (GRGDS) sequence that binds to cell surface integrins
             (primarily alpha(v)beta(3) heterodimer) to promote cell-cell
             attachment and cell spreading. A 70-kDa acidic protein was
             previously detected by two-dimensional (2D) PAGE in Day 17
             pregnant endometrial cytosolic extracts using Stainsall and
             identified as immunoreactive OPN using Western blotting.
             Three forms of immunoreactive OPN proteins (70, 45, and 24
             kDa) were detected by 1D PAGE and Western blot analysis of
             endometrial extracts. OPN protein in endometrial extracts
             did not differ between cyclic and pregnant ewes. However,
             the amount of 45-kDa OPN increased in uterine flushings from
             pregnant ewes between Days 11 and 17. Immunoreactive OPN was
             localized to luminal and glandular epithelia of both cyclic
             and pregnant ewes, and to trophectoderm of Day 19
             conceptuses. The alpha(v) and beta(3) integrins were
             detected on Day 19 endometrium and conceptuses by
             immunofluorescence. It was reported that OPN mRNA increases
             in the uterine glands of pregnant ewes and secretion of OPN
             protein into the uterine lumen increases during early
             pregnancy. The present results demonstrate accumulation of
             OPN protein on endometrial LE and conceptus trophectoderm.
             Therefore, it is hypothesized that progesterone and/or
             interferon-tau induce expression, secretion and/or
             proteolytic cleavage of OPN by uterine epithelium. Secreted
             OPN is then available as ligand for alpha(v)beta(3) integrin
             heterodimer on trophectoderm and uterus to 1) stimulate
             changes in morphology of conceptus trophectoderm and 2)
             induce adhesion between luminal epithelium and trophectoderm
             essential for implantation and placentation.},
   Language = {eng},
   Key = {fds174167}
}

@article{fds269070,
   Author = {Chen, XJ and Möller, HE and Chawla, MS and Cofer, GP and Driehuys, B and Hedlund, LW and MacFall, JR and Johnson, GA},
   Title = {Spatially resolved measurements of hyperpolarized gas
             properties in the lung in vivo. Part II: T
             *(2).},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {42},
   Number = {4},
   Pages = {729-737},
   Year = {1999},
   Month = {October},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10502762},
   Keywords = {Animals • Guinea Pigs • Helium • Humans
             • Isotopes • Lung • Magnetic Resonance
             Imaging • Male • Middle Aged • Pulmonary
             Diffusing Capacity • Trachea • Xenon Isotopes
             • anatomy & histology • anatomy & histology*
             • diagnostic use • methods*},
   Abstract = {The transverse relaxation time, T *(2), of hyperpolarized
             (HP) gas in the lung in vivo is an important parameter for
             pulse sequence optimization and image contrast. We obtained
             T *(2) maps of HP (3)He and (129)Xe in guinea pig lungs (n =
             17) and in human lungs. Eight different sets of (3)He guinea
             pig studies were acquired, with variation of slice
             selection, tidal volume, and oxygen level. For example, for
             a (3)He tidal volume of 3 cm(3) and no slice selection, the
             average T *(2) in the trachea was 14.7 ms and 8.0 ms in the
             intrapulmonary airspaces. The equivalent (129)Xe experiment
             yielded an average T *(2) of 40.8 ms in the trachea and 18.5
             ms in the intrapulmonary airspaces. The average (3)He T *(2)
             in the human intrapulmonary airspaces was 9.4 ms. The
             relaxation behavior was predicted by treating the lung as a
             porous medium, resulting in good agreement between estimated
             and measured T *(2) values in the intrapulmonary airspaces.
             Magn Reson Med 42:729-737, 1999.},
   Key = {fds269070}
}

@booklet{Carroll99,
   Author = {T. L. Carroll and G. A. Johnson and L. M. Pecora and D. J.
             Mar},
   Title = {Parameter-insensitive and narrow-band synchronization of
             chaotic circuits},
   Journal = {International Journal Of Bifurcation And
             Chaos},
   Volume = {9},
   Number = {11},
   Pages = {2189 -- 2196},
   Year = {1999},
   Month = {November},
   Key = {Carroll99}
}

@booklet{Johnson99a,
   Author = {G. A. Johnson and R. C. Burghardt and G. R. Newton and F. W.
             Bazer and T. E. Spencer},
   Title = {Development and characterization of immortalized ovine
             endometrial cell lines},
   Journal = {Biology Of Reproduction},
   Volume = {61},
   Number = {5},
   Pages = {1324 -- 1330},
   Year = {1999},
   Month = {November},
   Key = {Johnson99a}
}

@booklet{Nelson99,
   Author = {Nelson, RC and Johnson, GA and Spielman, AL and Lowry, CR and Sundaramoorthy, G and Sheafor, DH},
   Title = {Single breath-hold dynamic subtraction CT of the liver
             using-multidetector helical technology},
   Journal = {Radiology},
   Volume = {213P},
   Pages = {125-125},
   Year = {1999},
   Month = {November},
   Key = {Nelson99}
}

@article{fds174198,
   Author = {GA Johnson and RC Burghardt and GR Newton and FW Bazer and TE
             Spencer},
   Title = {Development and characterization of immortalized ovine
             endometrial cell lines.},
   Journal = {Biology of reproduction},
   Volume = {61},
   Number = {5},
   Pages = {1324-30},
   Year = {1999},
   Month = {November},
   ISSN = {0006-3363},
   Keywords = {Animals • Blotting, Western • Cell Line •
             Cell Nucleus • DNA-Binding Proteins • Endocrine
             System • Endometrium • Female • Fluorescent
             Antibody Technique, Direct • Interferon Regulatory
             Factor-1 • Interferon Type I • Microscopy,
             Fluorescence • Paracrine Communication •
             Phosphoproteins • Pregnancy Proteins • Receptors,
             Estrogen • Receptors, Progesterone • Recombinant
             Proteins • Sheep • Signal Transduction •
             Transcription Factors • Ubiquitins • analogs &
             derivatives • biosynthesis • cytology* •
             metabolism • physiology},
   Abstract = {The objective of this study was to generate immortalized
             endometrial epithelial and stromal cell lines from the ovine
             uterus. Luminal (LE) and glandular epithelial (GE) cells and
             stromal (ST) cells were enzymatically isolated from the
             uterus of a Day 5 cyclic ewe (estrus on Day 0), and primary
             cultures were immortalized by transduction with a retroviral
             vector (LXSN-16E6E7) packaged by the amphotropic fibroblast
             line PA-317. Cells having integrated the vector were
             selected by resistance to the neomycin analogue G418
             (0.6-0.8 mg/ml). Surviving cells were maintained in complete
             culture medium containing G418 (0.1 mg/ml) and subcultured
             for more than 40 passages. Phase-contrast microscopy
             revealed that LE and GE cells exhibited a cobblestone
             morphology whereas immortalized ST cells were spindle
             shaped. The epithelial origin of LE and GE was confirmed by
             positive cytokeratin immunostaining, and ST cells were
             vimentin positive. All cell lines were negative for smooth
             muscle alpha-actin staining. Western blot analyses of cell
             extracts revealed the presence of signal transducers and
             activators of transcription (STAT) proteins 1, 2, and 3. In
             the LE cells, interferon tau (IFNtau) induced nuclear
             translocation of STAT proteins 1 and 2 and up-regulated
             several IFN-inducible genes, including STATs 1, 2, and 3 and
             ubiquitin cross-reactive protein (UCRP/ISG17). In the LE
             cell line, IFN regulatory factor one was transiently
             up-regulated and then down-regulated by IFNtau.
             Immunostaining revealed the presence of nuclear estrogen
             receptor and progesterone receptor in all cell lines. These
             ovine endometrial cell lines provide useful in vitro model
             systems for the study of hormone and cytokine action, signal
             transduction pathways, cell-cell interactions, and gene
             expression in specific cell types of the ovine
             endometrium.},
   Language = {eng},
   Key = {fds174198}
}

@article{fds268897,
   Author = {Benveniste, H and Einstein, G and Kim, KR and Hulette, C and Johnson,
             GA},
   Title = {Detection of neuritic plaques in Alzheimer's disease by
             magnetic resonance microscopy.},
   Journal = {Proceedings of the National Academy of Sciences of
             USA},
   Volume = {96},
   Number = {24},
   Pages = {14079-14084},
   Year = {1999},
   Month = {November},
   ISSN = {0027-8424},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10570201},
   Keywords = {Aged • Aged, 80 and over • Alzheimer Disease
             • Coloring Agents • Humans • Magnetic
             Resonance Imaging • Middle Aged • Protons •
             Senile Plaques • methods • pathology*},
   Abstract = {Magnetic resonance microscopy (MRM) theoretically provides
             the spatial resolution and signal-to-noise ratio needed to
             resolve neuritic plaques, the neuropathological hallmark of
             Alzheimer's disease (AD). Two previously unexplored MR
             contrast parameters, T2* and diffusion, are tested for
             plaque-specific contrast to noise. Autopsy specimens from
             nondemented controls (n = 3) and patients with AD (n = 5)
             were used. Three-dimensional T2* and diffusion MR images
             with voxel sizes ranging from 3 x 10(-3) mm(3) to 5.9 x
             10(-5) mm(3) were acquired. After imaging, specimens were
             cut and stained with a microwave king silver stain to
             demonstrate neuritic plaques. From controls, the alveus,
             fimbria, pyramidal cell layer, hippocampal sulcus, and
             granule cell layer were detected by either T2* or diffusion
             contrast. These structures were used as landmarks when
             correlating MRMs with histological sections. At a voxel
             resolution of 5.9 x 10(-5) mm(3), neuritic plaques could be
             detected by T2*. The neuritic plaques emerged as black,
             spherical elements on T2* MRMs and could be distinguished
             from vessels only in cross-section when presented in three
             dimension. Here we provide MR images of neuritic plaques in
             vitro. The MRM results reported provide a new direction for
             applying this technology in vivo. Clearly, the ability to
             detect and follow the early progression of amyloid-positive
             brain lesions will greatly aid and simplify the many
             possibilities to intervene pharmacologically in
             AD.},
   Key = {fds268897}
}

@booklet{Scribner99,
   Author = {D. R. Scribner and R. S. Mannel and J. L. Walker and G. A.
             Johnson},
   Title = {Cost analysis of laparoscopy versus laparotomy for early
             endometrial cancer},
   Journal = {Gynecologic Oncology},
   Volume = {75},
   Number = {3},
   Pages = {460 -- 463},
   Year = {1999},
   Month = {December},
   Key = {Scribner99}
}

@booklet{Spencer99,
   Author = {T. E. Spencer and A. Gray and G. A. Johnson and K. M. Taylor and A. Gertler and E. Gootwine and T. L. Ott and F. W.
             Bazer},
   Title = {Effects of recombinant ovine interferon tau, placental
             lactogen, and growth hormone on the ovine
             uterus},
   Journal = {Biology Of Reproduction},
   Volume = {61},
   Number = {6},
   Pages = {1409 -- 1418},
   Year = {1999},
   Month = {December},
   Key = {Spencer99}
}

@article{fds174304,
   Author = {TE Spencer and A Gray and GA Johnson and KM Taylor and A Gertler and E
             Gootwine, TL Ott and FW Bazer},
   Title = {Effects of recombinant ovine interferon tau, placental
             lactogen, and growth hormone on the ovine
             uterus.},
   Journal = {Biology of reproduction},
   Volume = {61},
   Number = {6},
   Pages = {1409-18},
   Year = {1999},
   Month = {December},
   ISSN = {0006-3363},
   Keywords = {Animals • Corpus Luteum • Endometrium •
             Female • Gene Expression • Glycoproteins •
             Growth Hormone • Interferon Type I • Ki-67 Antigen
             • Ovariectomy • Placental Lactogen •
             Pregnancy Proteins • RNA, Messenger • Receptors,
             Estrogen • Receptors, Oxytocin • Receptors,
             Progesterone • Recombinant Proteins • Serpins*
             • Sheep* • analysis • chemistry • drug
             effects • genetics • pharmacology •
             pharmacology* • physiology • physiology*},
   Abstract = {Studies were conducted to determine effects of intrauterine
             administration of recombinant ovine interferon tau (IFNtau),
             placental lactogen (PL), and growth hormone (GH) on
             endometrial function. In the first study, administration of
             IFNtau to cyclic ewes for one period (Days 11-15) resulted
             in an interestrous interval (IEI) of approximately 30 days,
             whereas administration for two periods (Days 11-15 and Days
             21-25) extended the IEI to greater than 50 days.
             Administration of IFNtau from Days 11 to 15 and of PL or GH
             from Days 21 to 25 failed to extend the IEI more than for
             IFNtau alone. In the second study, effects of IFNtau, PL,
             and GH on endometrial differentiation and function were
             determined in ovariectomized ewes receiving ovarian steroid
             replacement therapy. Endometrial expression of mRNAs for
             estrogen receptor (ER), progesterone receptor (PR), and
             oxytocin receptor (OTR) were not affected by PL or GH
             treatment; however, uterine milk protein mRNA levels and
             stratum spongiosum gland density were increased by both PL
             and GH treatments. Collectively, results indicated that 1)
             PL and GH do not regulate endometrial PR, ER, and OTR
             expression or affect corpus luteum life span; 2)
             down-regulation of epithelial PR expression is requisite for
             progesterone induction of secretory gene expression in
             uterine glandular epithelium; 3) effects of PL and GH on
             endometrial function require IFNtau; and 4) PL and GH
             regulate endometrial gland proliferation and perhaps
             differentiated function.},
   Language = {eng},
   Key = {fds174304}
}

@article{fds174313,
   Author = {DR Scribner Jr and RS Mannel and JL Walker and GA
             Johnson},
   Title = {Cost analysis of laparoscopy versus laparotomy for early
             endometrial cancer.},
   Journal = {Gynecologic oncology},
   Volume = {75},
   Number = {3},
   Pages = {460-3},
   Year = {1999},
   Month = {December},
   ISSN = {0090-8258},
   url = {http://dx.doi.org/10.1006/gyno.1999.5606},
   Keywords = {Aged • Costs and Cost Analysis • Endometrial
             Neoplasms • Female • Humans • Laparoscopy
             • Laparotomy • Lymph Node Excision • Neoplasm
             Staging • Retrospective Studies • economics*
             • pathology • surgery*},
   Abstract = {OBJECTIVE: The purpose of this study was to determine
             whether the cost associated with treatment of early stage
             endometrial cancer differs on the basis of the surgical
             approach. METHODS: A retrospective analysis was performed on
             a series of women with presumed early stage endometrial
             cancer treated between 5/96 and 1/99 at a single
             institution. The patients were grouped according to the
             surgical approach utilized. The first group consisted of 19
             patients who underwent laparoscopic assisted vaginal
             hysterectomy, bilateral salpingo-oophorectomy, and
             laparoscopic pelvic and paraaortic lymph node dissection.
             The second group consisted of 17 patients who underwent a
             total abdominal hysterectomy, bilateral salpingo-oophorectomy,
             and pelvic and paraaortic lymph node dissection. The two
             groups were compared with a two-tailed Student t test.
             Variables analyzed included age, Quetelet index (QI),
             surgical stage, number of lymph nodes, surgical time,
             estimated blood loss, postoperative complications, number of
             days in the hospital, and costs. The cost analysis was
             divided into room and board, pharmacy, ancillary services,
             operating room equipment, operating room services, and
             anesthesia. RESULTS: Both groups were similar in age, QI,
             and distribution of stage. The laparoscopic group required
             more OR time (237 vs 157 min, P < 0.001); however, the
             number of lymph nodes, estimated blood loss, and
             postoperative complications were not significantly different
             between the groups. The laparoscopic group required
             significantly shorter hospitalization than the laparotomy
             group (3.7 vs 5.2 days, P < 0.001) resulting in less room
             and board ($299 vs $454, P < 0.001) as well as pharmacy
             costs ($443 vs $625, P < 0.02). The cost of anesthesia was
             higher in the laparoscopic group ($696 vs $444, P < 0.001)
             but the costs of OR equipment, OR services, and total costs
             were not statistically different between the groups.
             CONCLUSION: Laparoscopic surgical management of early stage
             endometrial cancer is feasible with minimal morbidity. The
             cost savings of early hospital discharge is offset by longer
             surgical time and higher anesthetic costs. The total costs
             for each surgical approach are not statistically different.
             The presumed advantages of less pain, early resumption of
             normal activities, and overall improvement of quality of
             life await further investigation.},
   Language = {eng},
   Doi = {10.1006/gyno.1999.5606},
   Key = {fds174313}
}

@booklet{Wang00,
   Author = {G. Y. Wang and G. A. Johnson and T. E. Spencer and F. W.
             Bazer},
   Title = {Isolation, immortalization, and initial characterization of
             uterine cell lines: An in vitro model system for the porcine
             uterus},
   Journal = {In Vitro Cellular \& Developmental Biology-animal},
   Volume = {36},
   Number = {10},
   Pages = {650 -- 656},
   Year = {2000},
   Key = {Wang00}
}

@booklet{Colbach00,
   Author = {N. Colbach and F. Forcella and G. A. Johnson},
   Title = {Spatial and temporal stability of weed populations over five
             years},
   Journal = {Weed Science},
   Volume = {48},
   Number = {3},
   Pages = {366 -- 377},
   Year = {2000},
   Key = {Colbach00}
}

@booklet{Lester00,
   Author = {Lester, DS and Pine, PS and Delnomdedieu, M and Johannessen, JN and Johnson, GA},
   Title = {Virtual neuropathology: Three-dimensional visualization of
             lesions due to toxic insult},
   Journal = {Toxicologic Pathology (Sage)},
   Volume = {28},
   Number = {1},
   Pages = {100-104},
   Year = {2000},
   ISSN = {0192-6233},
   Abstract = {A first-pass approach incorporating high-field magnetic
             resonance imaging (MRI) was used for rapid detection of
             neuropathologic lesions in fixed rat brains. This inherently
             3-dimensional and nondestructive technique provides
             high-resolution, high-contrast images of fixed neuronal
             tissue in the absence of sectioning or staining. This
             technique, magnetic resonance microscopy (MRM), was used to
             identify diverse lesions in 2 well-established rat
             neurotoxicity models. The intrinsic contrast in the images
             delineated lesions that were identified using a battery of
             histologic stains, some of which would not be used in
             routine screening. Furthermore, the MRM images provided the
             locations of lesions, which were verified upon subsequent
             sectioning and staining of the same samples. The inherent
             contrast generated by water properties is exploited in MRM
             by choosing suitable pulse sequences, or proton stains. This
             approach provides the potential for a comprehensive initial
             MRM screen for neurotoxicity in preclinical models with the
             capability for extrapolation to clinical analyses using
             classical MRI.},
   Key = {Lester00}
}

@article{fds289613,
   Author = {Nugent, AC and Johnson, GA},
   Title = {Imaging using magnetization-prepared projection encoding
             (MaPPE)},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {43},
   Number = {3},
   Pages = {421-428},
   Year = {2000},
   url = {http://dx.doi.org/10.1002/(SICI)1522-2594(200003)43:3<421::AID-MRM14>3.0.CO;2-},
   Abstract = {T(1p), contrast weighting using a magnetization-prepared
             projection encoding (MaPPE) pulse sequence was investigated.
             Fast radial imaging was implemented by applying
             magnetization preparation pulses, each followed by multiple
             RF α pulses encoding radial trajectories of k-space.
             Acquiring multiple views per preparatory pulse imposes
             view-to-view variation; the resultant distortion of the
             point-spread function is examined. The issue of maximizing
             signal while preserving the intended contrast weighting is
             addressed. Under modification of repetition time and flip
             angle (α), three distinct behavior regimes of the sequence
             are identified. The utility of the pulse sequence as a
             quantitative relaxation measurement tool is also examined by
             comparing imaging and spectroscopy experiments. A mouse was
             imaged in vitro to demonstrate the viability of application
             to MR histology. These images exhibit the utility of
             spinlocking and projection encoding as an alternative
             contrast source to both T2-weighted MaPPE images and
             conventional T2-weighted spin-echo images. (C) 2000
             Wiley-Liss, Inc.},
   Doi = {10.1002/(SICI)1522-2594(200003)43:3<421::AID-MRM14>3.0.CO;2-},
   Key = {fds289613}
}

@booklet{Oliverio00,
   Author = {Oliverio, MI and Delnomdedieu, M and Best, CF and Li, P and Morris, M and Callahan, MF and Johnson, GA and Smithies, O and Coffman,
             TM},
   Title = {Abnormal water metabolism in mice lacking the type 1A
             receptor for ANG II},
   Journal = {American journal of physiology. Renal physiology},
   Volume = {278},
   Number = {1 47-1},
   Pages = {F75-F82},
   Year = {2000},
   ISSN = {0363-6127},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10644657},
   Abstract = {Mice lacking AT1(A) receptors for ANG II have a defect in
             urinary concentration manifested by an inability to increase
             urinary osmolality to levels seen in controls after
             thirsting. This defect results in extreme serum
             hypertonicity during water deprivation. In the basal state,
             plasma vasopressin levels are similar in wild-type controls
             and Agtr 1a -/- mice. Plasma vasopressin levels increase
             normally in the AT(1A) receptor-deficient mice after 24 h of
             water deprivation, suggesting that the defect in urine
             concentration is intrinsic to the kidney. Using magnetic
             resonance microscopy, we find that the absence of AT(1A)
             receptors is associated with a modest reduction in the
             distance from the kidney surface to the tip of the papilla.
             However, this structural abnormality seems to play little
             role in the urinary concentrating defect in Agtr 1a -/- mice
             since the impairment is largely reproduced in wild-type mice
             by treatment with an AT1-receptor antagonist. These studies
             demonstrate a critical role for the AT(1A) receptor in
             maintaining inner medullary structures in the kidney and in
             regulating renal water excretion.},
   Key = {Oliverio00}
}

@booklet{Ka00,
   Author = {H. H. Ka and L. A. Jaeger and G. A. Johnson and T. E.
             Spencer and F. W. Bazer},
   Title = {Regulation of keratinocyte growth factor expression and its
             function in the porcine uterus.},
   Journal = {Biology Of Reproduction},
   Volume = {62},
   Pages = {297 -- 297},
   Year = {2000},
   Key = {Ka00}
}

@booklet{Stewart00,
   Author = {M. D. Stewart and G. A. Johnson and R. C. Burghardt and C.
             A. Vyhlidal and S. H. Safe and F. W. Bazer and T. E.
             Spencer},
   Title = {Effects of interferon tau on short- and long-term activation
             of STAT proteins in immortalized ovine uterine luminal
             epithelial cells.},
   Journal = {Biology Of Reproduction},
   Volume = {62},
   Pages = {118 -- 118},
   Year = {2000},
   Key = {Stewart00}
}

@booklet{Hicks00,
   Author = {B. A. Hicks and K. G. Carnahan and J. A. Baldock and S. J.
             Yankee and F. W. Bazer and G. A. Johnson and T. E. Spencer and T. L. Ott},
   Title = {Expression of the antiviral protein Mx in an immortalized
             ovine uterine glandular epithelial cell line.},
   Journal = {Biology Of Reproduction},
   Volume = {62},
   Pages = {288 -- 289},
   Year = {2000},
   Key = {Hicks00}
}

@booklet{Bazer00,
   Author = {F. W. Bazer and J. A. G. W. Fleming and G. A. Johnson and Y.
             S. Choi and M. D. Stewart and T. E. Spencer},
   Title = {Interferon tau inhibits transcription of the ovine estrogen
             receptor alpha gene: Involvement of STATs and
             IRFs.},
   Journal = {Biology Of Reproduction},
   Volume = {62},
   Pages = {292 -- 292},
   Year = {2000},
   Key = {Bazer00}
}

@booklet{Jaeger00,
   Author = {L. A. Jaeger and R. C. Burghardt and G. A. Johnson and F. W.
             Bazer},
   Title = {Activation of conceptus and maternal integrins by
             transforming growth factor beta latency associated
             peptide.},
   Journal = {Biology Of Reproduction},
   Volume = {62},
   Pages = {281 -- 281},
   Year = {2000},
   Key = {Jaeger00}
}

@booklet{Johnson00,
   Author = {G. A. Johnson and F. W. Bazer and L. A. Jaeger and T. E.
             Spencer and C. Pfarrer and R. C. Burghardt},
   Title = {Role of MUC-1, integrins and extracellular matrix components
             in the implantation cascade in sheep.},
   Journal = {Biology Of Reproduction},
   Volume = {62},
   Pages = {281 -- 282},
   Year = {2000},
   Key = {Johnson00}
}

@booklet{Garlow00,
   Author = {J. E. Garlow and H. H. Ka and G. A. Johnson and L. A. Jaeger and R. C. Burghardt and F. W. Bazer},
   Title = {Role of osteopontin during early pregnancy in
             pigs.},
   Journal = {Biology Of Reproduction},
   Volume = {62},
   Pages = {282 -- 282},
   Year = {2000},
   Key = {Garlow00}
}

@booklet{Spencer00,
   Author = {T. E. Spencer and G. A. Johnson and M. D. Stewart and M. M.
             Joyce and C. A. Gray and K. M. Taylor and A. Gertler and E.
             Gootwine and F. W. Bazer},
   Title = {Effects of ovine placental lactogen and growth hormone on
             ovine endometrial function.},
   Journal = {Biology Of Reproduction},
   Volume = {62},
   Pages = {264 -- 264},
   Year = {2000},
   Key = {Spencer00}
}

@article{fds310029,
   Author = {Oliverio, MI and Delnomdedieu, M and Best, CF and Li, P and Morris, M and Callahan, MF and Johnson, GA and Smithies, O and Coffman,
             TM},
   Title = {Abnormal water metabolism in mice lacking the type 1A
             receptor for ANG II.},
   Journal = {American Journal of Physiology: Renal Physiology},
   Volume = {278},
   Number = {1},
   Pages = {F75-F82},
   Year = {2000},
   Month = {January},
   ISSN = {1931-857X},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10644657},
   Keywords = {Animals • Body Weight • Deamino Arginine
             Vasopressin • Female • Genotype • Kidney
             • Kidney Concentrating Ability • Losartan •
             Male • Mice • Osmolar Concentration •
             Receptor, Angiotensin, Type 1 • Receptors, Angiotensin
             • Urine • Urodynamics • Vasopressins •
             Water • Water Deprivation • anatomy & histology
             • antagonists & inhibitors • blood •
             chemistry • deficiency* • drug effects •
             genetics • metabolism* • pharmacology •
             physiology*},
   Abstract = {Mice lacking AT(1A) receptors for ANG II have a defect in
             urinary concentration manifested by an inability to increase
             urinary osmolality to levels seen in controls after
             thirsting. This defect results in extreme serum
             hypertonicity during water deprivation. In the basal state,
             plasma vasopressin levels are similar in wild-type controls
             and Agtr1a -/- mice. Plasma vasopressin levels increase
             normally in the AT(1A) receptor-deficient mice after 24 h of
             water deprivation, suggesting that the defect in urine
             concentration is intrinsic to the kidney. Using magnetic
             resonance microscopy, we find that the absence of AT(1A)
             receptors is associated with a modest reduction in the
             distance from the kidney surface to the tip of the papilla.
             However, this structural abnormality seems to play little
             role in the urinary concentrating defect in Agtr1a -/- mice
             since the impairment is largely reproduced in wild-type mice
             by treatment with an AT(1)-receptor antagonist. These
             studies demonstrate a critical role for the AT(1A) receptor
             in maintaining inner medullary structures in the kidney and
             in regulating renal water excretion.},
   Key = {fds310029}
}

@booklet{Johnson00c,
   Author = {G. A. Johnson and S. V. Mantha and T. A.
             Day},
   Title = {A spectrofluorometric survey of UV-induced blue-green
             fluorescence in foliage of 35 species},
   Journal = {Journal Of Plant Physiology},
   Volume = {156},
   Number = {2},
   Pages = {242 -- 252},
   Year = {2000},
   Month = {February},
   Key = {Johnson00c}
}

@booklet{Jaeger00a,
   Author = {L. A. Jaeger and L. S. Bustamante and G. A. Johnson and F.
             W. Bazer and R. C. Burghardt},
   Title = {Functional activation of conceptus and maternal
             integrins},
   Journal = {Faseb Journal},
   Volume = {14},
   Number = {4},
   Pages = {A783 -- A783},
   Year = {2000},
   Month = {March},
   Key = {Jaeger00a}
}

@booklet{Chawla00,
   Author = {M. S. Chawla and X. J. Chen and G. P. Cofer and L. W.
             Hedlund and M. B. Kerby and T. B. Ottoboni and G. A.
             Johnson},
   Title = {Hyperpolarized He-3 microspheres as a novel vascular signal
             source for MRI},
   Journal = {Magnetic Resonance In Medicine},
   Volume = {43},
   Number = {3},
   Pages = {440 -- 445},
   Year = {2000},
   Month = {March},
   Key = {Chawla00}
}

@booklet{Johnson00d,
   Author = {G. A. Johnson and T. E. Spencer and R. C. Burghardt and M.
             M. Joyce and F. W. Bazer},
   Title = {Interferon-tau and progesterone regulate ubiquitin
             cross-reactive protein expression in the ovine
             uterus},
   Journal = {Biology Of Reproduction},
   Volume = {62},
   Number = {3},
   Pages = {622 -- 627},
   Year = {2000},
   Month = {March},
   Key = {Johnson00d}
}

@booklet{Rogers00,
   Author = {P. Rogers and P. A. Hailey and G. A. Johnson and V. A. Dight and C. Read and A. Shingler and P. Savage and T. Roche and J. Mondry},
   Title = {A comprehensive and flexible approach to the
             automated-dissolution testing of pharmaceutical drug
             products incorporating direct UV-vis fiber-optic analysis,
             on-line fluorescence analysis, and off-line storage
             options},
   Journal = {Laboratory Robotics And Automation},
   Volume = {12},
   Number = {1},
   Pages = {12 -- 22},
   Year = {2000},
   Month = {March},
   Key = {Rogers00}
}

@booklet{Nugent00,
   Author = {Nugent, AC and Johnson, GA},
   Title = {T1rho imaging using magnetization-prepared projection
             encoding (MaPPE).},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {43},
   Number = {3},
   Pages = {421-428},
   Year = {2000},
   Month = {March},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10725885},
   Abstract = {T1rho contrast weighting using a magnetization-prepared
             projection encoding (MaPPE) pulse sequence was investigated.
             Fast radial imaging was implemented by applying
             magnetization preparation pulses, each followed by multiple
             RF alpha pulses encoding radial trajectories of k-space.
             Acquiring multiple views per preparatory pulse imposes
             view-to-view variation; the resultant distortion of the
             point-spread function is examined. The issue of maximizing
             signal while preserving the intended contrast weighting is
             addressed. Under modification of repetition time and flip
             angle (alpha), three distinct behavior regimes of the
             sequence are identified. The utility of the pulse sequence
             as a quantitative relaxation measurement tool is also
             examined by comparing imaging and spectroscopy experiments.
             A mouse was imaged in vitro to demonstrate the viability of
             application to MR histology. These images exhibit the
             utility of spinlocking and projection encoding as an
             aftemative contrast source to both T2-weighted MaPPE images
             and conventional T2-weighted spin-echo images.},
   Key = {Nugent00}
}

@article{fds132847,
   Author = {AC Nugent and GA Johnson},
   Title = {T1rho imaging using magnetization-prepared projection
             encoding (MaPPE).},
   Journal = {Magnetic resonance in medicine : official journal of the
             Society of Magnetic Resonance in Medicine / Society of
             Magnetic Resonance in Medicine, UNITED STATES},
   Volume = {43},
   Number = {3},
   Pages = {421-8},
   Year = {2000},
   Month = {March},
   ISSN = {0740-3194},
   Keywords = {Animals • Image Enhancement • Magnetic Resonance
             Spectroscopy • Magnetics • Mathematics • Mice
             • Phantoms, Imaging • Time Factors •
             methods*},
   Abstract = {T1rho contrast weighting using a magnetization-prepared
             projection encoding (MaPPE) pulse sequence was investigated.
             Fast radial imaging was implemented by applying
             magnetization preparation pulses, each followed by multiple
             RF alpha pulses encoding radial trajectories of k-space.
             Acquiring multiple views per preparatory pulse imposes
             view-to-view variation; the resultant distortion of the
             point-spread function is examined. The issue of maximizing
             signal while preserving the intended contrast weighting is
             addressed. Under modification of repetition time and flip
             angle (alpha), three distinct behavior regimes of the
             sequence are identified. The utility of the pulse sequence
             as a quantitative relaxation measurement tool is also
             examined by comparing imaging and spectroscopy experiments.
             A mouse was imaged in vitro to demonstrate the viability of
             application to MR histology. These images exhibit the
             utility of spinlocking and projection encoding as an
             aftemative contrast source to both T2-weighted MaPPE images
             and conventional T2-weighted spin-echo images.},
   Key = {fds132847}
}

@article{fds174133,
   Author = {GA Johnson and TE Spencer and RC Burghardt and MM Joyce and FW
             Bazer},
   Title = {Interferon-tau and progesterone regulate ubiquitin
             cross-reactive protein expression in the ovine
             uterus.},
   Journal = {Biology of reproduction},
   Volume = {62},
   Number = {3},
   Pages = {622-7},
   Year = {2000},
   Month = {March},
   ISSN = {0006-3363},
   Keywords = {Animals • Blotting, Western • Female •
             Hormone Antagonists • Hysterectomy • In Situ
             Hybridization • Interferon Type I • Pregnancy
             Proteins • Progesterone • Sheep • Ubiquitins
             • Uterus • analogs & derivatives* •
             antagonists & inhibitors • drug effects • genetics
             • metabolism • metabolism* • pharmacology
             • physiology},
   Abstract = {Ubiquitin cross-reactive protein (UCRP) is a functional
             ubiquitin homolog synthesized by the ruminant endometrium in
             response to conceptus-derived interferon-tau (IFNtau).
             Progesterone is required for IFNtau to exert antiluteolytic
             actions on the endometrium. Therefore, this study was
             designed to determine whether progesterone is requisite for
             IFNtau induction of UCRP expression within the ovine uterus.
             Cyclic ewes were ovariectomized and fitted with intrauterine
             (i.u.) catheters on Day 5 and treated daily with steroids
             (i.m.) and protein (i.u.) as follows: 1) progesterone (P,
             Days 5-24) and control serum proteins (CX, Days 11-24); 2) P
             and ZK 137.316 (ZK; progesterone receptor antagonist, Days
             11-24) and CX proteins; 3) P and recombinant ovine IFNtau
             (roIFNtau, Days 11-24); or 4) P and ZK and roIFNtau. All
             ewes were hysterectomized on Day 25. In P-treated ewes,
             roIFNtau increased endometrial UCRP mRNA and protein levels.
             However, administration of ZK to ewes ablated roIFNtau
             induction of UCRP. Recombinant ovine IFNtau induced
             expression of UCRP mRNA in progestinized endometrial luminal
             (LE) and glandular (GE) epithelium as well as in both
             stratum compactum and spongiosum layers of the stroma (ST).
             Progesterone receptor protein was located in endometrial ST,
             but not in LE and GE from these ewes. Results support the
             hypothesis that progesterone is required for IFNtau
             induction of type I IFN-responsive genes, such as UCRP, in
             the ruminant uterus.},
   Language = {eng},
   Key = {fds174133}
}

@article{fds269056,
   Author = {Chawla, MS and Chen, XJ and Cofer, GP and Hedlund, LW and Kerby, MB and Ottoboni, TB and Johnson, GA},
   Title = {Hyperpolarized 3He microspheres as a novel vascular signal
             source for MRI.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {43},
   Number = {3},
   Pages = {440-445},
   Year = {2000},
   Month = {March},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10725887},
   Keywords = {Animals • Helium • Image Enhancement •
             Magnetic Resonance Angiography* • Male •
             Microscopy, Electron, Scanning • Microspheres •
             Pelvis • Phantoms, Imaging • Rats • blood
             supply • chemistry* • methods},
   Abstract = {Hyperpolarized (HP) 3He can be encapsulated within
             biologically compatible microspheres while retaining
             sufficient polarization to be used as a signal source for
             MRI. Two microsphere sizes were used, with mean diameters of
             5.3 +/- 1.3 microm and 10.9 +/- 3.0 microm. These
             suspensions ranged in concentration from 0.9-7.0% gas by
             volume. Spectroscopic measurements in phantoms at 2 T
             yielded 3He relaxation times that varied with gas
             concentration. At the highest 3He concentration, the
             spinlattice relaxation time, T1, was 63.8 +/- 9.4 sec, while
             the transverse magnetization decayed with a time constant of
             T2* = 11.0 +/- 0.4 msec. In vivo MR images of the pelvic
             veins in a rat were acquired during intravenous injection of
             3He microspheres (SNR approximately equal 15). Advantages
             such as intravascular confinement, lack of background
             signal, and limited recirculation indicate quantitative
             perfusion measurements may be improved using this novel
             signal source.},
   Key = {fds269056}
}

@booklet{Johnson00b,
   Author = {G. A. Johnson and T. E. Spencer and R. C. Burghardt and K.
             M. Taylor and C. A. Gray and F. W. Bazer},
   Title = {Progesterone modulation of osteopontin gene expression in
             the ovine uterus},
   Journal = {Biology Of Reproduction},
   Volume = {62},
   Number = {5},
   Pages = {1315 -- 1321},
   Year = {2000},
   Month = {May},
   Key = {Johnson00b}
}

@article{fds174108,
   Author = {GA Johnson and TE Spencer and RC Burghardt and KM Taylor and CA Gray and FW
             Bazer},
   Title = {Progesterone modulation of osteopontin gene expression in
             the ovine uterus.},
   Journal = {Biology of reproduction},
   Volume = {62},
   Number = {5},
   Pages = {1315-21},
   Year = {2000},
   Month = {May},
   ISSN = {0006-3363},
   Keywords = {Animals • Blotting, Western • Endometrium •
             Epithelial Cells • Female • Fluorescent Antibody
             Technique • Gene Expression • In Situ
             Hybridization • Interferons • Osteopontin •
             Ovariectomy • Progesterone • Receptors,
             Progesterone • Recombinant Proteins • Sheep •
             Sialoglycoproteins • Uterus • antagonists &
             inhibitors • cytology • drug effects •
             genetics* • metabolism • metabolism* •
             pharmacology • physiology • physiology*},
   Abstract = {Osteopontin (OPN) is an acidic phosphorylated glycoprotein
             component of the extracellular matrix that binds to
             integrins at the cell surface to promote cell-cell
             attachment and cell spreading. This matrix constituent is a
             ligand that could potentially bind integrins on
             trophectoderm and endometrium to facilitate superficial
             implantation and placentation. OPN mRNA increases in the
             endometrial glandular epithelium (GE) of early-pregnant
             ewes, and OPN protein is secreted into the uterine lumen.
             Therefore, progesterone and/or interferon-tau (IFNtau) may
             regulate OPN expression in the uterine GE. Cyclic ewes were
             ovariectomized and fitted with intrauterine (i. u.)
             catheters on Day 5 and treated daily with steroids (i.m.)
             and protein (i.u.) as follows: 1) progesterone (P, Days
             5-24) and control serum proteins (CX, Days 11-24); 2) P and
             ZK 136.317 (ZK; progesterone receptor [PR] antagonist, Days
             11-24) and CX proteins; 3) P and recombinant ovine IFNtau
             (roIFNtau, Days 11-24); or 4) P and ZK and roIFNtau. All
             ewes were hysterectomized on Day 25. Progesterone induced
             the expression of endometrial OPN mRNA in the GE and
             increased secretion of a 45-kDa OPN protein from endometrial
             explants maintained in culture for 24 h. Administration of
             ZK ablated progesterone effects. Intrauterine infusion of
             roIFNtau did not affect OPN gene expression or secretion in
             any of the steroid treatments. Interestingly, OPN
             mRNA-positive GE cells lacked detectable PR expression,
             although PR were detected in the stroma. Results indicate
             that progesterone regulates OPN expression in GE through a
             complex mechanism that includes PR down-regulation, and we
             suggest the possible involvement of a progesterone-induced
             stromal cell-derived growth factor(s) that acts as a
             progestamedin.},
   Language = {eng},
   Key = {fds174108}
}

@booklet{Hedlund00a,
   Author = {L. W. Hedlund and H. E. Moller and X. J. Chen and M. S.
             Chawla and G. P. Cofer and G. A. Johnson},
   Title = {Mixing oxygen with hyperpolarized He-3 for small-animal lung
             studies},
   Journal = {Nmr In Biomedicine},
   Volume = {13},
   Number = {4},
   Pages = {202 -- 206},
   Year = {2000},
   Month = {June},
   Key = {Hedlund00a}
}

@booklet{Stewart00a,
   Author = {M. D. Stewart and G. A. Johnson and C. A. Gray and R. C.
             Burghardt and L. A. Schuler and M. M. Joyce and F. W. Bazer and T. E. Spencer},
   Title = {Prolactin receptor and uterine milk protein expression in
             the ovine endometrium during the estrous cycle and
             pregnancy},
   Journal = {Biology Of Reproduction},
   Volume = {62},
   Number = {6},
   Pages = {1779 -- 1789},
   Year = {2000},
   Month = {June},
   Key = {Stewart00a}
}

@booklet{Scribner00,
   Author = {D. R. Scribner and J. Baldwin and G. A. Johnson},
   Title = {Actinomycosis mimicking a pelvic malignancy - A case
             report},
   Journal = {Journal Of Reproductive Medicine},
   Volume = {45},
   Number = {6},
   Pages = {515 -- 518},
   Year = {2000},
   Month = {June},
   Key = {Scribner00}
}

@booklet{Ka00a,
   Author = {H. Ka and T. E. Spencer and G. A. Johnson and F. W.
             Bazer},
   Title = {Keratinocyte growth factor: Expression by endometrial
             epithelia of the porcine uterus},
   Journal = {Biology Of Reproduction},
   Volume = {62},
   Number = {6},
   Pages = {1772 -- 1778},
   Year = {2000},
   Month = {June},
   Key = {Ka00a}
}

@booklet{Benveniste00,
   Author = {Benveniste, H and Kim, K and Zhang, L and Johnson,
             GA},
   Title = {Magnetic resonance microscopy of the C57BL mouse
             brain},
   Journal = {NeuroImage},
   Volume = {11},
   Number = {6},
   Pages = {601-611},
   Year = {2000},
   Month = {June},
   ISSN = {1053-8119},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000087963600003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Doi = {10.1006/nimg.2000.0567},
   Key = {Benveniste00}
}

@article{fds174080,
   Author = {H Ka and TE Spencer and GA Johnson and FW Bazer},
   Title = {Keratinocyte growth factor: expression by endometrial
             epithelia of the porcine uterus.},
   Journal = {Biology of reproduction},
   Volume = {62},
   Number = {6},
   Pages = {1772-8},
   Year = {2000},
   Month = {June},
   ISSN = {0006-3363},
   Keywords = {Animals • Blotting, Northern • Cloning, Molecular
             • DNA, Complementary • Endometrium •
             Epithelium • Estrus • Female • Fibroblast
             Growth Factor 10 • Fibroblast Growth Factor 7 •
             Fibroblast Growth Factors* • Gene Expression* •
             Growth Substances • In Situ Hybridization •
             Pregnancy • RNA, Messenger • Swine* •
             analysis • genetics* • metabolism •
             metabolism*},
   Abstract = {Keratinocyte growth factor/fibroblast growth factor-7
             (KGF/FGF-7) is an established paracrine mediator of
             hormone-regulated epithelial growth and differentiation. In
             all organs studied, KGF is uniquely expressed in cells of
             mesenchymal origin. To determine whether KGF and its
             receptor, keratinocyte growth factor receptor (KGFR) or
             fibroblast growth factor receptor-2IIIb, were expressed in
             the porcine uterus as a potential paracrine system mediating
             progesterone action, we cloned KGF and KGFR partial cDNAs
             from the porcine endometrium. KGF and KGFR expression was
             detected in endometrium by Northern blot hybridization.
             Interestingly, in situ hybridization results demonstrated
             that KGF was expressed by endometrial epithelia and was
             particularly abundant between Days 12 and 15 of the estrous
             cycle and pregnancy. KGF secretion into the lumen of the
             porcine uterus was also detected on Day 12 of the estrous
             cycle and pregnancy. KGFR was expressed in both endometrial
             epithelia and conceptus trophectoderm. These novel findings
             suggest that KGF may act on the uterine endometrial
             epithelium in an autocrine manner and on the conceptus
             trophectoderm in a paracrine manner in the pig, which is the
             only species possessing a true epitheliochorial type of
             placentation.},
   Language = {eng},
   Key = {fds174080}
}

@article{fds174216,
   Author = {MD Stewart and GA Johnson and CA Gray and RC Burghardt and LA Schuler and MM Joyce and FW Bazer and TE Spencer},
   Title = {Prolactin receptor and uterine milk protein expression in
             the ovine endometrium during the estrous cycle and
             pregnancy.},
   Journal = {Biology of reproduction},
   Volume = {62},
   Number = {6},
   Pages = {1779-89},
   Year = {2000},
   Month = {June},
   ISSN = {0006-3363},
   Keywords = {Animals • Endometrium • Estrus • Female
             • Fluorescent Antibody Technique • Gene
             Expression* • Glycoproteins • Immunohistochemistry
             • In Situ Hybridization • Pregnancy • RNA,
             Messenger • Receptors, Prolactin • Reverse
             Transcriptase Polymerase Chain Reaction • Serpins*
             • Sheep* • analysis • genetics* •
             metabolism* • physiology*},
   Abstract = {Lactogenic hormones regulate epithelial proliferation,
             differentiation, and function in a variety of
             epitheliomesenchymal organs. During pregnancy, the ovine
             uterus is a potential site for endocrine and paracrine
             actions of lactogenic hormones in the form of pituitary
             prolactin (PRL) and placental lactogen (PL). These studies
             determined temporal and spatial alterations in PRL receptor
             (PRL-R) and expression of uterine milk proteins (UTMP), a
             marker of endometrial secretory activity, in the ovine
             endometrium during the estrous cycle and pregnancy.
             Slot-blot hybridization analysis indicated that steady-state
             levels of endometrial PRL-R mRNA increased during pregnancy.
             In situ hybridization and immunohistochemical analyses
             indicated that PRL-R mRNA and protein were exclusively
             expressed in the endometrial glandular epithelium (GE). No
             PRL-R mRNA expression was detected in luminal epithelium,
             stroma, myometrium, or conceptus trophectoderm. Reverse
             transcription-polymerase chain reaction analyses determined
             that the endometrial GE expressed both long and short
             alternative splice forms of the ovine PRL-R gene. Slot-blot
             hybridization analysis indicated that steady-state levels of
             intercaruncular endometrial UTMP mRNA increased about 3-fold
             between Days 20 and 60, increased another 3-fold between
             Days 60 and 80, and then declined slightly to Day 120. In
             pregnant ewes, UTMP mRNA expression was restricted to the
             endometrial GE in the stratum spongiosum (sGE), increased
             substantially between Days 15 and 17, and, between Days 17
             to 50 of gestation, was markedly higher in upper than lower
             sGE. After Day 50, hyperplasia of the sGE was accompanied by
             increased UTMP mRNA expression by all sGE. Collectively,
             results indicate that 1) endometrial sGE is a primary target
             for actions of lactogenic hormones and 2) UTMP mRNA
             expression is correlated with PL production by the
             trophectoderm and state of sGE differentiation during
             pregnancy. It is proposed that activation of PRL-R signal
             transduction pathways by PRL and PL plays a major role in
             endometrial GE remodeling and differentiated function during
             pregnancy in support of conceptus growth and
             development.},
   Language = {eng},
   Key = {fds174216}
}

@article{fds174257,
   Author = {DR Scribner Jr and J Baldwin and GA Johnson},
   Title = {Actinomycosis mimicking a pelvic malignancy. A case
             report.},
   Journal = {The Journal of reproductive medicine},
   Volume = {45},
   Number = {6},
   Pages = {515-8},
   Year = {2000},
   Month = {June},
   ISSN = {0024-7758},
   Keywords = {Abdominal Pain • Actinomycosis • Colorectal
             Neoplasms • Diagnosis, Differential • Female
             • Humans • Middle Aged • Uterine Diseases
             • complications • diagnosis • diagnosis*
             • etiology* • pathology •
             surgery},
   Abstract = {BACKGROUND: Pelvic actinomycosis is difficult to diagnose
             preoperatively. The chronic infection is locally
             infiltrative and causes a profound induration of infected
             tissue planes. This induration, combined with absence of
             fever and leukocytosis, can mimic a pelvic malignancy. CASE:
             A 55-year-old woman was diagnosed with a pelvic mass after a
             two-month history of intermittent lower abdominal pain. The
             patient had had an intrauterine device for 12 years; it was
             removed two months prior to an exploratory laparotomy for
             the symptomatic mass. The mass was highly suggestive of
             colorectal cancer, with the rectosigmoid colon indurated and
             adherent to the uterus and sacrum. The induration of the
             colon extended caudally to within 3 cm of the anal verge. An
             abdominoperineal resection was performed along with a total
             abdominal hysterectomy, bilateral salpingo-oophorectomy and
             colostomy. Pathology revealed acute and chronic
             endometritis, left tuboovarian abscess and extensive, acute
             inflammation of the rectosigmoid colon without evidence of
             diverticuli. Actinomycosis was diagnosed based on the
             characteristic sulphur granules seen on hemotoxylin and
             eosin staining. CONCLUSION: Actinomycosis can mimic pelvic
             and abdominal malignancies. Surgeons should be aware of this
             infection to potentially spare women morbidity from
             excessive surgical procedures.},
   Language = {eng},
   Key = {fds174257}
}

@article{fds268988,
   Author = {Hedlund, LW and Möller, HE and Chen, XJ and Chawla, MS and Cofer, GP and Johnson, GA},
   Title = {Mixing oxygen with hyperpolarized (3)He for small-animal
             lung studies.},
   Journal = {Nmr in Biomedicine},
   Volume = {13},
   Number = {4},
   Pages = {202-206},
   Year = {2000},
   Month = {June},
   ISSN = {0952-3480},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10867697},
   Keywords = {Animals • Animals, Laboratory • Helium* •
             Intubation, Intratracheal • Isotopes • Lung •
             Magnetic Resonance Imaging • Oxygen* • Rats •
             Respiratory Function Tests • anatomy & histology •
             instrumentation • methods* • physiology*},
   Abstract = {Hyperpolarized helium (HP (3)He) is useful for direct MR
             imaging of the gas spaces of small animal lungs. Previously,
             breaths of 100% HP (3)He were alternated with breaths of air
             to maximize helium signal in the lungs and to minimize the
             depolarizing effects of O(2). However, for high-resolution
             imaging requiring many HP (3)He breaths (hundreds) and for
             pulmonary disease studies, a method was needed to
             simultaneously deliver O(2) and HP (3)He with each breath
             without significant loss of polarization. We modified our
             existing computer-controlled ventilator by adding a plastic
             valve, additional relays and a controller. O(2) and HP (3)He
             are mixed at the beginning of each breath within the body of
             a breathing valve, which is attached directly to the
             endotracheal tube. With this mixing method, we found that
             T(1) relaxation of HP (3)He in the guinea pig lung was about
             20 s compared to 30 s with alternate air/HP (3)He breathing.
             Because imaging times during each breath are short (about
             500 ms), the HP (3)He signal loss from O(2) contact is
             calculated to be less than 5%. We concluded that the
             advantages of mixing HP (3)He with O(2), such as shorter
             imaging times (reduced T(1) losses in reservoir) and
             improved physiologic stability, outweigh the small signal
             loss from the depolarizing effects of oxygen on HP
             (3)He.},
   Key = {fds268988}
}

@article{fds292763,
   Author = {Benveniste, H and Kim, K and Zhang, L and Johnson,
             GA},
   Title = {Magnetic resonance microscopy of the C57BL mouse
             brain.},
   Journal = {NeuroImage},
   Volume = {11},
   Number = {6 Pt 1},
   Pages = {601-611},
   Year = {2000},
   Month = {June},
   ISSN = {1053-8119},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10860789},
   Keywords = {Animals • Brain • Caudate Nucleus • Globus
             Pallidus • Hippocampus • Image Enhancement •
             Magnetic Resonance Spectroscopy* • Mice • Mice,
             Inbred C57BL • Neocortex • Putamen • anatomy
             & histology • anatomy & histology*},
   Abstract = {With the rapid progression in gene technologies, transgenic,
             targeted, and chemically induced mutations in mice are
             continually created. The major goal of these studies is to
             understand and characterize the effects of genotype on
             anatomy, physiology, and behavior and ultimately the role of
             genotype in development of disease. The demand for imaging
             techniques with high spatial resolution potential is rising
             because such imaging tools would expedite anatomical
             phenotyping in the genetically altered mice. Magnetic
             resonance microscopy (MRM) is a noninvasive, inherently
             three-dimensional (3D) imaging technique capable of
             visualizing several anatomical structures in the small
             mouse. The 3D nature of MRM also allows for interpretation
             of complex spatial relationships between substructures,
             which is important when phenotyping anatomically. The goal
             of this paper is to systematically describe three major
             brain regions in the C57BL/6J mouse at microanatomical
             spatial resolution ranges using in vitro MRM. We explore
             different MR contrast parameters, voxel sizes, and
             signal-to-noise ratios to best characterize C57BL/6J mouse
             brain microstructure by MRM. Further, we compare all MRM
             images with Nissl-stained brain sections. Major findings
             were as follows: T2* MR images visualized several gross
             anatomical regions in the mouse brain but not, for example,
             subregions within the hippocampus. Diffusion proton stains
             on the other hand were superior to T2* MR images and
             delineated many subregions within the hippocampus proper.
             Finally, contrast enhancement facilitated visualization of
             hippocampal anatomy on the T2* MR images. The results of
             this study are part of an ongoing initiative at our Center
             focused on creating a complete C57BL/6J mouse anatomical 3D
             image database by MRM.},
   Doi = {10.1006/nimg.2000.0567},
   Key = {fds292763}
}

@booklet{Hedlund00,
   Author = {Hedlund, LW and Cofer, GP and Owen, SJ and Allan Johnson,
             G},
   Title = {MR-compatible ventilator for small animals:
             computer-controlled ventilation for proton and noble gas
             imaging.},
   Journal = {Magnetic Resonance Imaging},
   Volume = {18},
   Number = {6},
   Pages = {753-759},
   Year = {2000},
   Month = {July},
   ISSN = {0730-725X},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/10930785},
   Abstract = {We describe an MR-compatible ventilator that is computer
             controlled to generate a variety of breathing patterns, to
             minimize image degrading effects of breathing motion, and to
             support delivery of gas anesthesia and experimental
             inhalational gases. A key feature of this ventilator is the
             breathing valve that attaches directly to the endotracheal
             tube to reduce dead volume and allows independent control of
             inspiratory and expiratory phases of ventilation. This
             ventilator has been used in a wide variety of MR and x-ray
             microscopy studies of small animals, especially for MR
             imaging the lungs with hyperpolarized gases ((3)He &
             (129)Xe).},
   Key = {Hedlund00}
}

@booklet{Johnson00a,
   Author = {G. A. Johnson and M. D. Todd and B. L. Althouse and C. C.
             Chang},
   Title = {Fiber Bragg grating interrogation and multiplexing with a 3
             x 3 coupler and a scanning filter},
   Journal = {Journal Of Lightwave Technology},
   Volume = {18},
   Number = {8},
   Pages = {1101 -- 1105},
   Year = {2000},
   Month = {August},
   Key = {Johnson00a}
}

@booklet{Lee00,
   Author = {C. K. Lee and R. L. Weaks and G. A. Johnson and F. W. Bazer and J. A. Piedrahita},
   Title = {Effects of protease inhibitors and antioxidants on in vitro
             survival of porcine primordial germ cells},
   Journal = {Biology Of Reproduction},
   Volume = {63},
   Number = {3},
   Pages = {887 -- 897},
   Year = {2000},
   Month = {September},
   Key = {Lee00}
}

@booklet{Posey00,
   Author = {R. Posey and G. A. Johnson and S. T. Vohra},
   Title = {Strain sensing based on coherent Rayleigh scattering in an
             optical fibre},
   Journal = {Electronics Letters},
   Volume = {36},
   Number = {20},
   Pages = {1688 -- 1689},
   Year = {2000},
   Month = {September},
   Key = {Posey00}
}

@article{fds174143,
   Author = {CK Lee and RL Weaks and GA Johnson and FW Bazer and JA
             Piedrahita},
   Title = {Effects of protease inhibitors and antioxidants on In vitro
             survival of porcine primordial germ cells.},
   Journal = {Biology of reproduction},
   Volume = {63},
   Number = {3},
   Pages = {887-97},
   Year = {2000},
   Month = {September},
   ISSN = {0006-3363},
   Keywords = {Acetylcysteine • Animals • Antioxidants •
             Apoptosis • Cell Survival • Cells, Cultured •
             DNA Fragmentation • Dose-Response Relationship, Drug
             • Fetus • Germ Cells • In Situ Nick-End
             Labeling • Microscopy, Electron • Protease
             Inhibitors • Swine • administration & dosage
             • alpha-Macroglobulins • cytology • drug
             effects • drug effects* • pharmacology •
             pharmacology* • physiology*},
   Abstract = {One of the problems associated with in vitro culture of
             primordial germ cells (PGCs) is the large loss of cells
             during the initial period of culture. This study
             characterized the initial loss and determined the
             effectiveness of two classes of apoptosis inhibitors,
             protease inhibitors, and antioxidants on the ability of
             porcine PGCs to survive in culture. Results from electron
             microscopic analysis and in situ DNA fragmentation assay
             indicated that porcine PGCs rapidly undergo apoptosis when
             placed in culture. Additionally, alpha(2)-macroglobulin, a
             protease inhibitor and cytokine carrier, and
             N:-acetylcysteine, an antioxidant, increased the survival of
             PGCs in vitro. While other protease inhibitors tested did
             not affect survival of PGCs, all antioxidants tested
             improved survival of PGCs (P: < 0.05). Further results
             indicated that the beneficial effect of the antioxidants was
             critical only during the initial period of culture. Finally,
             it was determined that in short-term culture, in the absence
             of feeder layers, antioxidants could partially replace the
             effect(s) of growth factors and reduce apoptosis.
             Collectively, these results indicate that the addition of
             alpha(2)-macroglobulin and antioxidants can increase the
             number of PGCs in vitro by suppressing apoptosis.},
   Language = {eng},
   Key = {fds174143}
}

@booklet{Chen00,
   Author = {X. J. Chen and L. W. Hedlund and H. E. Moller and M. S.
             Chawla and R. R. Maronpot and G. A. Johnson},
   Title = {Detection of emphysema in rat lungs by using magnetic
             resonance measurements of He-3 diffusion},
   Journal = {Proceedings Of The National Academy Of Sciences Of The
             United States Of America},
   Volume = {97},
   Number = {21},
   Pages = {11478 -- 11481},
   Year = {2000},
   Month = {October},
   Key = {Chen00}
}

@article{fds269111,
   Author = {Chen, XJ and Hedlund, LW and Möller, HE and Chawla, MS and Maronpot,
             RR and Johnson, GA},
   Title = {Detection of emphysema in rat lungs by using magnetic
             resonance measurements of 3He diffusion.},
   Journal = {Proceedings of the National Academy of Sciences of
             USA},
   Volume = {97},
   Number = {21},
   Pages = {11478-11481},
   Year = {2000},
   Month = {October},
   ISSN = {0027-8424},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/11027348},
   Keywords = {Animals • Emphysema • Helium • Humans •
             Lung • Magnetic Resonance Imaging • Male •
             Rats • Rats, Inbred F344 • diagnosis* •
             pathology*},
   Abstract = {Emphysema is a pulmonary disease characterized by alveolar
             wall destruction, resulting in enlargement of gas exchange
             spaces without fibrosis. This condition is a part of chronic
             obstructive pulmonary disease (COPD), which causes 3.5% of
             deaths worldwide [Anonymous (1990) World Health Stat. Q.
             Special, 1-51] and contributes greatly to the global burden
             of disease [Murray, C. J. & Lopez, A. D. (1996) Science 274,
             740-743]. Alveolar regeneration has been shown in animal
             models and could have potential for clinical treatment of
             early-stage emphysema. However, current techniques for
             detection of emphysema are not sensitive at the initial
             stages. Early-stage human panacinar emphysema is modeled in
             elastase-treated animals. Here, we provide an in vivo
             imaging method for differentiating normal and emphysematous
             rat lungs by measuring the apparent diffusion coefficient
             (ADC) of hyperpolarized (3)He by using magnetic resonance
             imaging. These data show that the ADC is significantly
             larger in elastase-treated rats, indicating alveolar
             expansion. Whereas these rats were clinically asymptomatic,
             conventional histology confirmed presence of injury. Our
             results indicate that measurement of the hyperpolarized
             (3)He ADC can be a valuable research tool and has potential
             application in the clinical setting.},
   Doi = {10.1073/pnas.97.21.11478},
   Key = {fds269111}
}

@booklet{Tengowski00,
   Author = {Tengowski, MW and Hedlund, LW and Guyot, DJ and Burkhardt, JE and Johnson, GA},
   Title = {Magnetic resonance microscopy predicts findings in a
             theophylline-induced rat model of reproductive
             toxicity},
   Journal = {Molecular Biology of the Cell},
   Volume = {11},
   Pages = {125A-125A},
   Year = {2000},
   Month = {December},
   ISSN = {1059-1524},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000165525900655&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Tengowski00}
}

@booklet{Jefferies01,
   Author = {B. Jefferies and G. A. Johnson},
   Title = {Feynman's operational calculi for noncommuting operators:
             Definitions and elementary properties},
   Journal = {Russian Journal Of Mathematical Physics},
   Volume = {8},
   Number = {2},
   Pages = {153 -- 171},
   Year = {2001},
   Key = {Jefferies01}
}

@booklet{Walsh01,
   Author = {B. Walsh and G. A. Johnson},
   Title = {Validation: Never an endpoint: A systems development life
             cycle approach to good clinical practice},
   Journal = {Drug Information Journal},
   Volume = {35},
   Number = {3},
   Pages = {809 -- 817},
   Year = {2001},
   Key = {Walsh01}
}

@article{fds174181,
   Author = {LA Jaeger and GA Johnson and H Ka and JG Garlow and RC Burghardt and TE
             Spencer, FW Bazer},
   Title = {Functional analysis of autocrine and paracrine signalling at
             the uterine-conceptus interface in pigs.},
   Journal = {Reproduction (Cambridge, England) Supplement},
   Volume = {58},
   Pages = {191-207},
   Year = {2001},
   ISSN = {1477-0415},
   Keywords = {Animals • Autocrine Communication • Blastocyst
             • Cell Communication • Cytokines • Embryo
             Implantation • Estrogens • Extracellular Matrix
             Proteins • Female • Growth Substances •
             Integrins • Paracrine Communication • Pregnancy
             • Progesterone • Receptors, Estrogen •
             Receptors, Progesterone • Swine • Uterus •
             metabolism • metabolism* • physiology •
             physiology*},
   Abstract = {The complexity of implantation necessitates intimate
             dialogue between conceptus and maternal cells, and precise
             coordination of maternal and conceptus signalling events.
             Maternal and conceptus-derived steroid hormones, growth
             factors and cytokines, as well as integrins and their
             ligands, have important and inter-related roles in mediating
             adhesion between apical aspects of conceptus trophectoderm
             and maternal uterine luminal epithelium that leads to
             formation of an epitheliochorial placenta. Integrin
             receptors appear to play fundamental roles in the
             implantation cascade and may interact with extracellular
             matrix molecules and other ligands to transduce cellular
             signals through autocrine and paracrine mechanisms.
             Functional in vitro analyses can be used to monitor
             individual contributions of specific integrin receptors and
             ligands to the signalling cascades of the maternal-conceptus
             interface. Integrative studies of implantation in pigs,
             using in vivo and in vitro approaches, are required to
             understand conceptus attachment and implantation in this
             species, and provide valuable opportunities to understand
             the fundamental mechanisms of implantation in all
             species.},
   Language = {eng},
   Key = {fds174181}
}

@booklet{Johnson01c,
   Author = {Johnson, GA and Cofer, GP and Hedlund, LW and Maronpot, RR and Suddarth,
             SA},
   Title = {Registered 1H and 3He magnetic
             resonance microscopy of the lung},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {45},
   Number = {3},
   Pages = {365-370},
   Year = {2001},
   url = {http://dx.doi.org/10.1002/1522-2594(200103)45:3<365::AID-MRM1047>3.0.CO;2-0},
   Abstract = {Using in vivo magnetic resonance microscopy, registered 1H
             and hyperpolarized 3He images of the rat lung were obtained
             with a resolution of 0.098 × 0.098 × 0.469 mm (4.5 × 10-3
             mm3). The requisite stability and SNR was achieved through
             an integration of scan-synchronous ventilation,
             dual-frequency RF coils, anisotropic projection encoding,
             and variable RF excitation. The total acquisition time was
             21 min for the 3He images and 64 min for the 1H image.
             Airways down to the 6th and 7th orders are clearly visible.
             © 2001 Wiley-Liss, Inc.},
   Doi = {10.1002/1522-2594(200103)45:3<365::AID-MRM1047>3.0.CO;2-0},
   Key = {Johnson01c}
}

@booklet{Choi01a,
   Author = {Y. Choi and G. A. Johnson and R. C. Burghardt and L. R.
             Berghman and M. M. Joyce and T. E. Spencer and F. W.
             Bazer},
   Title = {Epithelial expression of interferon regulatory factor two
             restricts expression of interferon tau-stimulated genes to
             the endometrial stroma and glandular epithelium of the ovine
             uterus.},
   Journal = {Biology Of Reproduction},
   Volume = {64},
   Pages = {108 -- 108},
   Year = {2001},
   Key = {Choi01a}
}

@booklet{Gray01a,
   Author = {C. A. Gray and G. A. Johnson and R. C. Burghardt and F. W.
             Bazer and T. E. Spencer},
   Title = {The defect in conceptus elongation in uterine gland knockout
             (UGKO) ewes is due to an absence of endometrial glands, but
             not differences in expression of lumenal epithelial adhesion
             molecules.},
   Journal = {Biology Of Reproduction},
   Volume = {64},
   Pages = {188 -- 188},
   Year = {2001},
   Key = {Gray01a}
}

@booklet{Bazer01,
   Author = {F. W. Bazer and T. E. Spencer and G. A. Johnson and R. C.
             Burghardt and L. A. Jaeger},
   Title = {Servomechanism in the ovine uterus for establishment and
             maintenance of pregnancy.},
   Journal = {Biology Of Reproduction},
   Volume = {64},
   Pages = {90 -- 90},
   Year = {2001},
   Key = {Bazer01}
}

@booklet{Johnson01a,
   Author = {G. A. Johnson and F. W. Bazer and J. E. Garlow and T. E.
             Spencer and C. T. Pfarrer and R. C. Burghardt},
   Title = {Osteopontin and activated alpha(v)beta(5) integrin receptors
             during implantation and placentation in sheep.},
   Journal = {Biology Of Reproduction},
   Volume = {64},
   Pages = {203 -- 203},
   Year = {2001},
   Key = {Johnson01a}
}

@booklet{Joyce01,
   Author = {M. M. Joyce and T. E. Spencer and F. W. Bazer and R. C.
             Burghardt and C. Pfarrer and G. A. Johnson},
   Title = {Evidence for stromal decidualization in the pregnant ovine
             uterus.},
   Journal = {Biology Of Reproduction},
   Volume = {64},
   Pages = {317 -- 318},
   Year = {2001},
   Key = {Joyce01}
}

@booklet{Ede01,
   Author = {P. N. Ede and G. A. Johnson},
   Title = {Energy relations of gas estimated from flare radiation in
             Nigeria},
   Journal = {International Journal Of Energy Research},
   Volume = {25},
   Number = {1},
   Pages = {85 -- 91},
   Year = {2001},
   Month = {January},
   Key = {Ede01}
}

@booklet{Stewart01a,
   Author = {D. M. Stewart and G. A. Johnson and C. A. Vyhlidal and R. C.
             Burghardt and S. H. Safe and L. Y. Yu-lee and F. W. Bazer and T. E. Spencer},
   Title = {Interferon-tau activates multiple signal transducer and
             activator of transcription proteins and has complex effects
             on interferon-responsive gene transcription in ovine
             endometrial epithelial cells},
   Journal = {Endocrinology},
   Volume = {142},
   Number = {1},
   Pages = {98 -- 107},
   Year = {2001},
   Month = {January},
   Key = {Stewart01a}
}

@booklet{Mermelstein01,
   Author = {M. D. Mermelstein and R. Posey and G. A. Johnson and S. T.
             Vohra},
   Title = {Rayleigh scattering optical frequency correlation in a
             single-mode optical fiber},
   Journal = {Optics Letters},
   Volume = {26},
   Number = {2},
   Pages = {58 -- 60},
   Year = {2001},
   Month = {January},
   Key = {Mermelstein01}
}

@article{fds174117,
   Author = {DM Stewart and GA Johnson and CA Vyhlidal and RC Burghardt and SH Safe and LY Yu-Lee and FW Bazer and TE Spencer},
   Title = {Interferon-tau activates multiple signal transducer and
             activator of transcription proteins and has complex effects
             on interferon-responsive gene transcription in ovine
             endometrial epithelial cells.},
   Journal = {Endocrinology},
   Volume = {142},
   Number = {1},
   Pages = {98-107},
   Year = {2001},
   Month = {January},
   ISSN = {0013-7227},
   Keywords = {Animals • Cell Nucleus • Cells, Cultured •
             DNA-Binding Proteins • Endometrium • Epithelial
             Cells • Female • Interferon Type I •
             Interferon-Stimulated Gene Factor 3 • Luciferases
             • Phosphorylation • Pregnancy Proteins •
             Promoter Regions, Genetic • Protein Transport •
             Recombinant Fusion Proteins • STAT1 Transcription
             Factor • STAT2 Transcription Factor • Sheep •
             Signal Transduction • Trans-Activators •
             Transcription Factors • Transcription, Genetic •
             Transfection • analysis • cytology • drug
             effects • genetics* • metabolism •
             metabolism* • pharmacology* • physiology •
             physiology*},
   Abstract = {Interferon-tau (IFNtau), a type I IFN produced by sheep
             conceptus trophectoderm, is the signal for maternal
             recognition of pregnancy. Although it is clear that IFNtau
             suppresses transcription of the estrogen receptor alpha and
             oxytocin receptor genes and induces expression of various
             IFN-stimulated genes within the endometrial epithelium,
             little is known of the signal transduction pathway activated
             by the hormone. This study determined the effects of IFNtau
             on signal transducer and activator of transcription (STAT)
             activation, expression, DNA binding, and transcriptional
             activation using an ovine endometrial epithelial cell line.
             IFNtau induced persistent tyrosine phosphorylation and
             nuclear translocation of STAT1 and -2 (10 min to 48 h), but
             transient phosphorylation and nuclear translocation of
             STAT3, -5a/b, and -6 (10 to <60 min). IFNtau increased
             expression of STAT1 and -2, but not STAT3, -5a/b, and -6.
             IFN-stimulated gene factor-3 and STAT1 homodimers formed and
             bound an IFN-stimulated response element (ISRE) and
             gamma-activated sequence (GAS) element, respectively. IFNtau
             increased transcription of GAS-driven promoters at 3 h, but
             suppressed their activity at 24 h. In contrast, the activity
             of an ISRE-driven promoter was increased at 3 and 24 h.
             These results indicate that IFNtau activates multiple STATs
             and has differential effects on ISRE- and GAS-driven gene
             transcription.},
   Language = {eng},
   Key = {fds174117}
}

@article{fds325756,
   Author = {Wetzel, AW and Pomerantz, S and Nave, D and Meixner, W and Johnson,
             GA},
   Title = {Distributed multiuser visualization of time varying
             anatomical data},
   Journal = {Proceedings - Applied Imagery Pattern Recognition
             Workshop},
   Volume = {2001-January},
   Pages = {109-114},
   Year = {2001},
   Month = {January},
   ISBN = {0769512453},
   url = {http://dx.doi.org/10.1109/AIPR.2001.991211},
   Abstract = {© 2001 IEEE. We describe a networked environment for
             navigating and visualizing 3-dimensional anatomical data
             with extensions for time varying volumes. The Duke Center
             for In Vivo Microscopy (CIVM) has been capturing volumetric
             data of mice using magnetic resonance microscopy. Current
             data sets are 51Z3 with 16 bit precision per voxel at an
             isotropic resolution of 50 microns. A new instrument will
             provide larger 512 ∗ 512 ∗ 2048 volumes. Because
             magnetic resonance imaging is nondestructive, both rapid
             time series and longer interval developmental series can be
             taken from living specimens. Our work builds on techniques
             put in place at the Pittsburgh Supercomputing Center and the
             University of Michigan for navigating Visible Human data
             using a client-server implementation, but applied to CIVM
             mouse data. Extension of the system to 4-dimensional data
             sets involves changes to compressed data representations and
             client viewing mechanisms. An essential aspect of the mouse
             studies is to facilitate comparison between different
             specimens, or even the same specimen over time, for studies
             of morphologic phenotype expression in gene
             knockouts.},
   Doi = {10.1109/AIPR.2001.991211},
   Key = {fds325756}
}

@article{fds174083,
   Author = {MD Mermelstein and R Posey Jr and GA Johnson and ST
             Vohra},
   Title = {Rayleigh scattering optical frequency correlation in a
             single-mode optical fiber.},
   Journal = {Optics letters},
   Volume = {26},
   Number = {2},
   Pages = {58-60},
   Year = {2001},
   Month = {January},
   ISSN = {0146-9592},
   Abstract = {The bichromatic optical frequency correlation function for
             Rayleigh backscattering from a pulse of laser light
             propagating along a single-mode optical fiber has been
             calculated and measured. It is shown that the optical
             correlation frequency, Dnu(c) , is equal to the reciprocal
             of pulse width T(w) . These results are important for the
             development of wavelength diversity techniques for the
             reduction of coherent Rayleigh noise in distributed Rayleigh
             backscattering single-mode optical fiber
             sensors.},
   Language = {eng},
   Key = {fds174083}
}

@booklet{Binelli01,
   Author = {M. Binelli and P. Subramaniam and T. Diaz and G. A. Johnson and T. R. Hansen and L. Badinga and W. W.
             Thatcher},
   Title = {Bovine interferon-tau stimulates the Janus kinase-signal
             transducer and activator of transcription pathway in bovine
             endometrial epithelial cells},
   Journal = {Biology Of Reproduction},
   Volume = {64},
   Number = {2},
   Pages = {654 -- 665},
   Year = {2001},
   Month = {February},
   Key = {Binelli01}
}

@article{fds174175,
   Author = {M Binelli and P Subramaniam and T Diaz and GA Johnson and TR Hansen and L
             Badinga, WW Thatcher},
   Title = {Bovine interferon-tau stimulates the Janus kinase-signal
             transducer and activator of transcription pathway in bovine
             endometrial epithelial cells.},
   Journal = {Biology of reproduction},
   Volume = {64},
   Number = {2},
   Pages = {654-65},
   Year = {2001},
   Month = {February},
   ISSN = {0006-3363},
   Keywords = {Animals • Cattle • DNA-Binding Proteins •
             Dimerization • Electrophoresis • Endometrium
             • Epithelial Cells • Female • Immunoblotting
             • Immunohistochemistry • Interferon Type I •
             Janus Kinase 1 • Nuclear Proteins • Phenotype
             • Phosphorylation • Precipitin Tests •
             Pregnancy Proteins • Protein-Tyrosine Kinases •
             STAT1 Transcription Factor • Signal Transduction •
             Time Factors • Trans-Activators • cytology •
             drug effects • drug effects* • enzymology •
             genetics* • metabolism • metabolism* •
             pharmacology*},
   Abstract = {Trophoblastic bovine interferon-tau (bIFN-tau) suppresses
             luteolytic pulses of endometrial prostaglandin F(2alpha)
             (PGF(2alpha)) at the time of maternal recognition of
             pregnancy. This results in maintenance of the corpus luteum
             in cattle. The hypothesis that effects of bIFN-tau in the
             endometrium were through activation of the Janus kinase
             (JAK)-signal transducer and activator of transcription
             (STAT) pathway of signal transduction was tested. Whole
             cell, cytosolic, and nuclear extracts from bovine
             endometrial cells treated with bIFN-tau were analyzed by
             immunoprecipitation, immunoblotting, and electrophoretic
             mobility shift assays in a series of dose- and
             time-dependency experiments. Bovine IFN-tau stimulated
             tyrosine phosphorylation, homo- and heterodimer formation,
             nuclear translocation, and DNA binding of STAT proteins 1,
             2, and 3. Moreover, bIFN-tau induced synthesis of
             interferon-regulatory factor. In conclusion, bIFN-tau
             stimulates the JAK-STAT pathway in the bovine endometrium.
             It is proposed that activation of the JAK-STAT pathway is
             involved in regulating the antiluteolytic effects of
             bIFN-tau.},
   Language = {eng},
   Key = {fds174175}
}

@booklet{Mantha01,
   Author = {S. V. Mantha and G. A. Johnson and T. A.
             Day},
   Title = {Evidence from action and fluorescence spectra that
             UV-induced violet-blue-green fluorescence enhances leaf
             photosynthesis},
   Journal = {Photochemistry And Photobiology},
   Volume = {73},
   Number = {3},
   Pages = {249 -- 256},
   Year = {2001},
   Month = {March},
   Key = {Mantha01}
}

@booklet{Asselin01,
   Author = {E. Asselin and G. A. Johnson and T. E. Spencer and F. W.
             Bazer},
   Title = {Monocyte chemotactic protein-1 and-2 messenger ribonucleic
             acids in the ovine uterus: Regulation by pregnancy,
             progesterone, and interferon-tau},
   Journal = {Biology Of Reproduction},
   Volume = {64},
   Number = {3},
   Pages = {992 -- 1000},
   Year = {2001},
   Month = {March},
   Key = {Asselin01}
}

@booklet{Moller01,
   Author = {H. E. Moller and L. W. Hedlund and X. J. Chen and M. R.
             Carey and M. S. Chawla and C. T. Wheeler and G. A.
             Johnson},
   Title = {Measurements of hyperpolarized gas properties in the lung.
             Part III: He-3 T-1},
   Journal = {Magnetic Resonance In Medicine},
   Volume = {45},
   Number = {3},
   Pages = {421 -- 430},
   Year = {2001},
   Month = {March},
   Key = {Moller01}
}

@article{fds174166,
   Author = {SV Mantha and GA Johnson and TA Day},
   Title = {Evidence from action and fluorescence spectra that
             UV-induced violet-blue-green fluorescence enhances leaf
             photosynthesis.},
   Journal = {Photochemistry and photobiology},
   Volume = {73},
   Number = {3},
   Pages = {249-56},
   Year = {2001},
   Month = {March},
   ISSN = {0031-8655},
   Keywords = {Angiosperms • Photosynthesis • Plant Leaves •
             Spectrometry, Fluorescence • Ultraviolet Rays* •
             physiology • radiation effects*},
   Abstract = {We assessed the contribution of UV-induced violet-blue-green
             leaf fluorescence to photosynthesis in Poa annua, Sorghum
             halepense and Nerium oleander by measuring UV-induced
             fluorescence spectra (280-380 nm excitation, 400-550 nm
             emission) from leaf surfaces and determining the
             monochromatic UV action spectra for leaf photosynthetic
             O2-evolution. Peak fluorescence emission wavelengths from
             leaf surfaces ranged from violet (408 nm) to blue (448 nm),
             while excitation peaks for these maxima ranged from 333 to
             344 nm. Action spectra were developed by supplementing
             monochromatic radiation from 280 to 440 nm, in 20 nm
             increments, to a visible nonsaturating background of 500
             mumol m-2 s-1 photosynthetically active radiation and
             measuring photosynthetic O2-evolution rates. Photosynthetic
             rates tended to be higher with the 340 nm supplement than
             with higher or lower wavelength UV supplements. Comparing
             photosynthetic rates with the 340 nm supplement to those
             with the 400 nm supplement, the percentage enhancement in
             photosynthetic rates at 340 nm ranged from 7.8 to 9.8%. We
             suspect that 340 nm UV improves photosynthetic rates via
             fluorescence that provides violet-blue-green photons for
             photosynthetic energy conversion because (1) the peak
             excitation wavelength (340 nm) for violet-blue-green
             fluorescence from leaves was also the most effective UV
             wavelength at enhancing photosynthetic rates, and (2) the
             magnitude of photosynthetic enhancements attributable to
             supplemental 340 nm UV was well correlated (R2 = 0.90) with
             the apparent intensity of 340 nm UV-induced
             violet-blue-green fluorescence emission from
             leaves.},
   Language = {eng},
   Key = {fds174166}
}

@article{fds174228,
   Author = {E Asselin and GA Johnson and TE Spencer and FW Bazer},
   Title = {Monocyte chemotactic protein-1 and -2 messenger ribonucleic
             acids in the ovine uterus: regulation by pregnancy,
             progesterone, and interferon-tau.},
   Journal = {Biology of reproduction},
   Volume = {64},
   Number = {3},
   Pages = {992-1000},
   Year = {2001},
   Month = {March},
   ISSN = {0006-3363},
   Keywords = {Animals • Chemokine CCL2 • Chemokine CCL8 •
             Endometrium • Estrus • Female •
             Histocytochemistry • Image Processing,
             Computer-Assisted • Interferon Type I • Monocyte
             Chemoattractant Proteins • Nucleic Acid Hybridization
             • Pregnancy • Pregnancy Proteins • Pregnancy,
             Animal • Progesterone • RNA, Messenger •
             Random Allocation • Recombinant Proteins • Reverse
             Transcriptase Polymerase Chain Reaction • Sheep •
             Steroids • biosynthesis • cytology • genetics
             • genetics* • metabolism • metabolism* •
             pharmacology • pharmacology* • physiology* •
             veterinary},
   Abstract = {Endometrial leukocytes may play important roles during
             pregnancy. Because chemokines are regulators of immune cell
             activity and trafficking, this study determined if mRNAs for
             monocyte chemotactic proteins (MCP) were present in the
             ovine uterus and regulated by progesterone (P) and/or
             recombinant ovine interferon tau (roIFN-tau). Uteri of
             normal cycling and pregnant ewes (experiment 1) and uteri of
             ovariectomized ewes receiving intrauterine infusions of
             IFN-tau and/or i.m. injections of P (experiment 2) were used
             to detect MCP-1 and MCP-2 mRNA. In experiment 1, slot-blot
             hybridization analysis of endometrial total RNA revealed
             that MCP-1 and MCP-2 mRNA levels did not change during the
             estrous cycle but increased between Days 13 and 19 of
             pregnancy. Using in situ hybridization, MCP-1 and MCP-2 mRNA
             were localized to immune cells in the subepithelial compact
             stroma. Histomorphological studies and in situ hybridization
             for major basic protein (MBP) indicated that MCP-positive
             immune cells were eosinophils. In experiment 2, treatment
             with P and roIFN-tau increased (P < 0.05) the number of
             MCP-1- and MCP-2-expressing eosinophils in the endometrium
             compared to ewes treated with P alone. Injection of the P
             receptor antagonist (ZK 137,316) inhibited effects of P
             and/or roIFN-tau to recruit eosinophils expressing MCP-1 and
             MCP-2 mRNAs. Endometrial production of MCPs by eosinophils
             during early pregnancy may play a role(s) in central
             implantation and/or placentation in ewes that is crucial for
             successful establishment of pregnancy.},
   Language = {eng},
   Key = {fds174228}
}

@article{fds268912,
   Author = {Johnson, GA and Cofer, GP and Hedlund, LW and Maronpot, RR and Suddarth,
             SA},
   Title = {Registered (1)H and (3)He magnetic resonance microscopy of
             the lung.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {45},
   Number = {3},
   Pages = {365-370},
   Year = {2001},
   Month = {March},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/11241691},
   Keywords = {Animals • Anisotropy • Helium* • Hydrogen*
             • Image Enhancement* • Image Processing,
             Computer-Assisted • Imaging, Three-Dimensional •
             Isotopes • Lung • Magnetic Resonance Imaging
             • Male • Microscopy • Rats • Rats,
             Inbred F344 • Sensitivity and Specificity •
             methods* • pathology*},
   Abstract = {Using in vivo magnetic resonance microscopy, registered (1)H
             and hyperpolarized (3)He images of the rat lung were
             obtained with a resolution of 0.098 x 0.098 x 0.469 mm (4.5
             x 10(-3) mm(3)). The requisite stability and SNR was
             achieved through an integration of scan-synchronous
             ventilation, dual-frequency RF coils, anisotropic projection
             encoding, and variable RF excitation. The total acquisition
             time was 21 min for the (3)He images and 64 min for the (1)H
             image. Airways down to the 6th and 7th orders are clearly
             visible. Magn Reson Med 45:365-370, 2001.},
   Doi = {10.1002/1522-2594(200103)45:3<365::AID-MRM1047>3.0.CO;2-0},
   Key = {fds268912}
}

@article{fds268938,
   Author = {Möller, HE and Hedlund, LW and Chen, XJ and Carey, MR and Chawla, MS and Wheeler, CT and Johnson, GA},
   Title = {Measurements of hyperpolarized gas properties in the lung.
             Part III: (3)He T(1).},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {45},
   Number = {3},
   Pages = {421-430},
   Year = {2001},
   Month = {March},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/11241699},
   Keywords = {Animals • Cardiac Output • Functional Residual
             Capacity • Guinea Pigs • Heart Arrest, Induced
             • Helium* • Image Enhancement* • Isotopes
             • Lung • Magnetic Resonance Spectroscopy* •
             Oxygen • Pulmonary Gas Exchange • blood •
             pathology • physiology • physiology*},
   Abstract = {Hyperpolarized (3)He spin-lattice relaxation was
             investigated in the guinea pig lung using spectroscopy and
             imaging techniques with a repetitive RF pulse series. T(1)
             was dominated by interactions with oxygen and was used to
             measure the alveolar O(2) partial pressure. In animals
             ventilated with a mixture of 79% (3)He and 21% O(2), T(1)
             dropped from 19.6 sec in vivo to 14.6 sec after cardiac
             arrest, reflecting the termination of the intrapulmonary gas
             exchange. The initial difference in oxygen concentration
             between inspired and alveolar air, and the temporal decay
             during apnea were related to functional parameters.
             Estimates of oxygen uptake were 29 +/- 11 mL min(-1) kg(-1)
             under normoxic conditions, and 9.0 +/- 2.0 mL min(-1) kg(-1)
             under hypoxic conditions. Cardiac output was estimated to be
             400 +/- 160 mL min(-1) kg(-1). The functional residual
             capacity derived from spirometric magnetic resonance
             experiments varied with body mass between 5.4 +/- 0.3 mL and
             10.7 +/- 1.1 mL. Magn Reson Med 45:421-430,
             2001.},
   Key = {fds268938}
}

@booklet{Kelly01,
   Author = {S. J. Kelly and M. Delnomdedieu and M. I. Oliverio and L. D.
             Williams and M. G. P. Saifer and M. R. Sherman and T. M.
             Coffman and G. A. Johnson and M. S. Hershfield},
   Title = {Diabetes insipidus in uricase-deficient mice: A model for
             evaluating therapy with poly(ethylene glycol)-modified
             uricase},
   Journal = {Journal Of The American Society Of Nephrology},
   Volume = {12},
   Number = {5},
   Pages = {1001 -- 1009},
   Year = {2001},
   Month = {May},
   Key = {Kelly01}
}

@booklet{Stewart01,
   Author = {M. D. Stewart and G. A. Johnson and F. W. Bazer and T. E.
             Spencer},
   Title = {Interferon-tau (IFN tau) regulation of IFN-stimulated gene
             expression in cell lines lacking specific IFN-signaling
             components},
   Journal = {Endocrinology},
   Volume = {142},
   Number = {5},
   Pages = {1786 -- 1794},
   Year = {2001},
   Month = {May},
   Key = {Stewart01}
}

@booklet{Johnson01b,
   Author = {G. A. Johnson and M. D. Stewart and C. A. Gray and Y. Choi and R. C. Burghardt and L. Y. Yu-lee and F. W. Bazer and T.
             E. Spencer},
   Title = {Effects of the estrous cycle, pregnancy, and interferon tau
             on 2 ',5 '-oligoadenylate synthetase expression in the ovine
             uterus},
   Journal = {Biology Of Reproduction},
   Volume = {64},
   Number = {5},
   Pages = {1392 -- 1399},
   Year = {2001},
   Month = {May},
   Key = {Johnson01b}
}

@article{fds174144,
   Author = {MD Stewart and GA Johnson and FW Bazer and TE Spencer},
   Title = {Interferon-tau (IFNtau) regulation of IFN-stimulated gene
             expression in cell lines lacking specific IFN-signaling
             components.},
   Journal = {Endocrinology},
   Volume = {142},
   Number = {5},
   Pages = {1786-94},
   Year = {2001},
   Month = {May},
   ISSN = {0013-7227},
   Keywords = {2',5'-Oligoadenylate Synthetase • Cell Line •
             DNA-Binding Proteins • Fibroblasts • Gene
             Expression Regulation • Humans • Interferon Type I
             • Interferon-Stimulated Gene Factor 3 •
             Interferon-Stimulated Gene Factor 3, gamma Subunit •
             Phosphorylation • Pregnancy Proteins • STAT1
             Transcription Factor • STAT2 Transcription Factor
             • STAT3 Transcription Factor • Trans-Activators
             • Transcription Factors • biosynthesis • drug
             effects* • genetics* • metabolism •
             pharmacology* • physiology},
   Abstract = {Interferon-tau (IFNtau) is a unique type I IFN secreted by
             the ruminant conceptus that acts in a paracrine manner on
             the endometrial epithelium to signal pregnancy recognition.
             In the ovine endometrium, IFNtau suppresses estrogen
             receptor alpha and oxytocin receptor gene expression, but
             increases or induces expression of IFN-simulated genes
             (ISGs), including signal transducer and activator of
             transcription-1 (STAT1), STAT2, ISG factor-3gamma
             (ISGF3gamma)/p48/IFN regulatory factor-9, and
             2',5'-oligoadenylate synthetase (OAS). Human fibroblast cell
             lines lacking specific IFN signaling components were
             employed to determine the roles of STAT1, STAT2, and
             ISGF3gamma in the effects of IFNtau on ISG protein
             expression. Results indicated that STAT1alpha or STAT1beta
             is required for IFNtau effects on STAT2, ISGF3gamma, and OAS
             (40/46, 69/71, and 100 kDa). STAT2 is required for effects
             on STAT1, ISGF3gamma, and all OAS forms. ISGF3gamma is
             required for effects of IFNtau on STAT2 and 40/46- and
             69/71-kDa OAS and plays a role in the effects of IFNtau on
             100-kDa OAS and STAT1. Mutation of Tyr(701), but not
             Ser(727), of STAT1 abolished the effects of IFNtau on ISG
             expression. Mutation of the SH2 domain of STAT1 abolished
             the effects of IFNtau on all ISGs and reduced increases in
             100-kDa OAS. These data illustrate the importance of
             transcription factors composed of STAT1, STAT2, and
             ISGF3gamma in the signaling pathway mediating the effects of
             IFNtau on ISG expression.},
   Language = {eng},
   Key = {fds174144}
}

@article{fds174204,
   Author = {GA Johnson, MD Stewart and CA Gray and Y Choi and RC Burghardt and LY
             Yu-Lee, FW Bazer and TE Spencer},
   Title = {Effects of the estrous cycle, pregnancy, and interferon tau
             on 2',5'-oligoadenylate synthetase expression in the ovine
             uterus.},
   Journal = {Biology of reproduction},
   Volume = {64},
   Number = {5},
   Pages = {1392-9},
   Year = {2001},
   Month = {May},
   ISSN = {0006-3363},
   Keywords = {2',5'-Oligoadenylate Synthetase • Animals • Cell
             Line • Endometrium • Estrus • Female •
             Gene Expression* • Interferon Type I • Pregnancy
             • Pregnancy Proteins • Recombinant Proteins •
             Sheep • Uterus • administration & dosage •
             drug effects • genetics* • metabolism •
             metabolism* • pharmacology • pharmacology* •
             physiology*},
   Abstract = {The enzymes which comprise the 2',5'-oligoadenylate
             synthetase (OAS) family are interferon (IFN) stimulated
             genes which regulate ribonuclease L antiviral responses and
             may play additional roles in control of cellular growth and
             differentiation. This study characterized OAS expression in
             the endometrium of cyclic and pregnant ewes as well as
             determined effects of IFNtau and progesterone on OAS
             expression in cyclic or ovariectomized ewes and in
             endometrial epithelial and stromal cell lines. In cyclic
             ewes, low levels of OAS protein were detected in the
             endometrial stroma (S) and glandular epithelium (GE). In
             early pregnant ewes, OAS expression increased in the S and
             GE on Day 15. OAS expression in the lumenal epithelium (LE)
             was not detected in uteri from either cyclic or pregnant
             ewes. Intrauterine administration of IFNtau stimulated OAS
             expression in the S and GE, and this effect of IFNtau was
             dependent on progesterone. Ovine endometrial LE, GE, and S
             cell lines responded to IFNtau with induction of OAS
             proteins. In all three cell lines, the 40/46-kDa OAS forms
             were induced by IFNtau, whereas the 100-kDa OAS form
             appeared to be constitutively expressed and not affected by
             IFNtau. The 69/71-kDa OAS forms were induced by IFNtau in
             the S and GE cell lines, but not in the LE. Collectively,
             these results indicate that OAS expression in the
             endometrial S and GE of the early pregnant ovine uterus is
             directly regulated by IFNtau from conceptus and requires the
             presence of progesterone.},
   Language = {eng},
   Key = {fds174204}
}

@article{fds269101,
   Author = {Kelly, SJ and Delnomdedieu, M and Oliverio, MI and Williams, LD and Saifer, MG and Sherman, MR and Coffman, TM and Johnson, GA and Hershfield, MS},
   Title = {Diabetes insipidus in uricase-deficient mice: a model for
             evaluating therapy with poly(ethylene glycol)-modified
             uricase.},
   Journal = {Journal of the American Society of Nephrology :
             JASN},
   Volume = {12},
   Number = {5},
   Pages = {1001-1009},
   Year = {2001},
   Month = {May},
   ISSN = {1046-6673},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/11316859},
   Keywords = {Animals • Body Water • Diabetes Insipidus •
             Disease Models, Animal • Gout • Humans •
             Kidney Concentrating Ability • Mice • Mice, Inbred
             C57BL • Mice, Knockout • Polyethylene Glycols
             • Recombinant Proteins • Urate Oxidase • Uric
             Acid • deficiency* • drug therapy • drug
             therapy* • enzymology* • genetics •
             metabolism • pathology • physiopathology •
             therapeutic use • therapeutic use* •
             urine},
   Abstract = {Uricase-deficient mice develop uric acid nephropathy, with
             high mortality rates before weaning. Urate excretion was
             quantitated and renal function was better defined in this
             study, to facilitate the use of these mice as a model for
             evaluating poly(ethylene glycol)-modified recombinant
             mammalian uricases (PEG-uricase) as a potential therapy for
             gout and uric acid nephropathy. The uric acid/creatinine
             ratio in the urine of uricase-deficient mice ranges from 10
             to >30; on a weight basis, these mice excrete 20- to 40-fold
             more urate than do human subjects. These mice consistently
             develop a severe defect in renal concentrating ability,
             resulting in an approximately sixfold greater urine volume
             and a fivefold greater fluid requirement, compared with
             normal mice. This nephrogenic diabetes insipidus leads to
             dehydration and death of nursing mice but, with adequate
             water replacement, high urine flow protects adults from
             progressive renal damage. Treatment of uricase-deficient
             mice with PEG-uricase markedly reduced urate levels and,
             when initiated before weaning, preserved the renal
             architecture (as evaluated by magnetic resonance
             micros-copy) and prevented the loss of renal concentrating
             function. PEG-uricase was far more effective and less
             immunogenic than unmodified uricase. Retention of uricase in
             most mammals and its loss in humans and some other primates
             may reflect the evolution of renal function under different
             environmental conditions. PEG-uricase could provide an
             effective therapy for uric acid nephropathy and refractory
             gout in human patients.},
   Key = {fds269101}
}

@article{fds174283,
   Author = {G Wang and GA Johnson and TE Spencer and FW Bazer},
   Title = {Isolation, immortalization, and initial characterization of
             uterine cell lines: an in vitro model system for the porcine
             uterus.},
   Journal = {In vitro cellular & developmental biology.
             Animal},
   Volume = {36},
   Number = {10},
   Pages = {650-6},
   Year = {2001},
   Month = {May},
   ISSN = {1071-2690},
   Keywords = {Animals • Blotting, Western • Cell Division •
             Cell Line, Transformed • Female • Models,
             Biological* • Swine • Uterus •
             cytology*},
   Abstract = {The aim of this study was to develop immortalized cell lines
             from porcine uterus. Endometrial cells including luminal
             epithelium (LE), glandular epithelium (GE), stroma (ST), and
             myometrium (MYO) were enzymatically isolated from the uterus
             of a day 12 pregnant gilt. Primary cultures were
             immortalized by transduction with a retroviral vector
             containing the E6 and E7 open reading frames of human
             papillomavirus type 16 (LXSN-16E6E7) packaged by the
             amphotropic fibroblast line PA-317. Cells having integrated
             the vector were selected by resistance to the neomycin
             analog G418 (0.4-1.5 mg/ml). Surviving cells were maintained
             in complete culture medium containing G418 (0.1 mg/ml) and
             subcultured for 1 yr. Expression of the E7 protein was
             confirmed in all cell lines by Western blotting. Phase
             contrast microscopy revealed that LE and GE cells exhibited
             cobblestone morphology, whereas ST and MYO cells exhibited
             spindle-shaped morphology. The epithelial origin of LE and
             GE was confirmed by positive immunostaining for cytokeratin.
             Stromal and MYO cells were vimentin-positive, but
             cytokeratin-negative. The MYO cell lines were positive for
             smooth muscle alpha-actin staining, whereas LE, GE, and ST
             cell lines were negative for alpha-actin. Western blotting
             indicated that all cell lines expressed both estrogen and
             progesterone receptors, but only GE cells secreted
             uteroferrin (UF). Collectively, these porcine uterine cell
             lines provide an in vitro model for studying cell
             type-specific actions of hormones and cytokines, signal
             transduction pathways, cell-cell interactions, and gene
             expression.},
   Language = {eng},
   Key = {fds174283}
}

@booklet{Ka01,
   Author = {H. Ka and L. A. Jaeger and G. A. Johnson and T. E. Spencer and F. W. Bazer},
   Title = {Keratinocyte growth factor is up-regulated by estrogen in
             the porcine uterine endometrium and functions in
             trophectoderm cell proliferation and differentiation},
   Journal = {Endocrinology},
   Volume = {142},
   Number = {6},
   Pages = {2303 -- 2310},
   Year = {2001},
   Month = {June},
   Key = {Ka01}
}

@booklet{Todd01a,
   Author = {M. D. Todd and G. A. Johnson and S. T. Vohra},
   Title = {Depolyment of a fiber Bragg grating-based measurement system
             in a structural health monitoring application},
   Journal = {Smart Materials \& Structures},
   Volume = {10},
   Number = {3},
   Pages = {534 -- 539},
   Year = {2001},
   Month = {June},
   Key = {Todd01a}
}

@booklet{Wang01,
   Author = {G. Wang and K. Pran and G. Sagvolden and G. B. Havsgard and A. E. Jensen and G. A. Johnson and S. T.
             Vohra},
   Title = {Ship hull structure monitoring using fibre optic
             sensors},
   Journal = {Smart Materials \& Structures},
   Volume = {10},
   Number = {3},
   Pages = {472 -- 478},
   Year = {2001},
   Month = {June},
   Key = {Wang01}
}

@article{fds174110,
   Author = {H Ka and LA Jaeger and GA Johnson and TE Spencer and FW
             Bazer},
   Title = {Keratinocyte growth factor is up-regulated by estrogen in
             the porcine uterine endometrium and functions in
             trophectoderm cell proliferation and differentiation.},
   Journal = {Endocrinology},
   Volume = {142},
   Number = {6},
   Pages = {2303-10},
   Year = {2001},
   Month = {June},
   ISSN = {0013-7227},
   Keywords = {Animals • Cell Differentiation • Cell Division
             • Culture Techniques • Endometrium • Enzyme
             Activation • Estradiol • Estrogens •
             Estrogens, Catechol • Female • Fibroblast Growth
             Factor 7 • Fibroblast Growth Factors • Gene
             Expression Regulation • Gestational Age •
             Mitogen-Activated Protein Kinase 1 • Mitogen-Activated
             Protein Kinase 3 • Mitogen-Activated Protein Kinases
             • Phosphorylation • Pregnancy • Progesterone
             • Proliferating Cell Nuclear Antigen • Receptor,
             Fibroblast Growth Factor, Type 2 • Receptors,
             Fibroblast Growth Factor* • Receptors, Growth Factor
             • Recombinant Proteins • Swine* •
             Trophoblasts • analysis • cytology • drug
             effects • genetics* • metabolism •
             metabolism* • pharmacology • pharmacology*},
   Abstract = {Keratinocyte growth factor (KGF) is expressed by uterine
             endometrial epithelial cells during the estrous cycle and
             during pregnancy in pigs, whereas KGF receptor is expressed
             in conceptus trophectoderm and endometrial epithelia. In
             particular, KGF expression in the endometrium is highest on
             day 12 of pregnancy. This corresponds to the period of
             maternal recognition of pregnancy in pigs, which is signaled
             by large amounts of estrogen secreted by conceptus
             trophectoderm acting on the endometrium. Our hypothesis is
             that estrogens of conceptus origin stimulate endometrial
             epithelial KGF expression, and, in turn, secreted KGF
             stimulates proliferation and differentiation of conceptus
             trophectoderm. To determine the factors affecting KGF
             expression in the uterus, endometrial explants from gilts on
             day 9 of the estrous cycle were cultured in the presence of
             17beta-estradiol, catechol estrogens, or progesterone.
             17beta-Estradiol stimulated the expression of KGF (P <
             0.05), whereas catechol estrogens had no effect (P > 0.05).
             Between days 9 and 15 of pregnancy, proliferating cell
             nuclear antigen was abundant in conceptuses, but was barely
             detectable in uterine endometrial epithelia. To determine
             the effects of KGF on conceptus trophectoderm, porcine
             trophectoderm (pTr) cells were treated with recombinant rat
             KGF (rKGF). rKGF increased the proliferation of pTr cells (P
             < 0.01) as measured by [(3)H]thymidine incorporation. rKGF
             elicited phosphorylation of KGF receptor and activated the
             mitogen-activated protein kinase (ERK1/2) cascade in pTr
             cells. pTr cell differentiation was affected by rKGF,
             because it increased expression of urokinase-type
             plasminogen activator, a marker for differentiation in pTr
             cells. Collectively, these results indicate that estrogen,
             the pregnancy recognition signal from the conceptus in pigs,
             increases uterine epithelial KGF expression, and, in turn,
             KGF stimulates the proliferation and differentiation of
             conceptus trophectoderm.},
   Language = {eng},
   Key = {fds174110}
}

@booklet{Todd01,
   Author = {M. D. Todd and G. A. Johnson and B. L. Althouse},
   Title = {A novel Bragg grating sensor interrogation system utilizing
             a scanning filter, a Mach-Zehnder interferometer and a 3 x 3
             coupler},
   Journal = {Measurement Science \& Technology},
   Volume = {12},
   Number = {7},
   Pages = {771 -- 777},
   Year = {2001},
   Month = {July},
   Key = {Todd01}
}

@booklet{Fleming01,
   Author = {J. A. G. W. Fleming and Y. Choi and G. A. Johnson and T. E.
             Spencer and F. W. Bazer},
   Title = {Cloning of the ovine estrogen receptor-alpha promoter and
             functional regulation by ovine interferon-tau},
   Journal = {Endocrinology},
   Volume = {142},
   Number = {7},
   Pages = {2879 -- 2887},
   Year = {2001},
   Month = {July},
   Key = {Fleming01}
}

@article{fds174194,
   Author = {JA Fleming and Y Choi and GA Johnson and TE Spencer and FW
             Bazer},
   Title = {Cloning of the ovine estrogen receptor-alpha promoter and
             functional regulation by ovine interferon-tau.},
   Journal = {Endocrinology},
   Volume = {142},
   Number = {7},
   Pages = {2879-87},
   Year = {2001},
   Month = {July},
   ISSN = {0013-7227},
   Keywords = {Animals • Artificial Gene Fusion • Base Sequence
             • Cell Line, Transformed • Cloning, Molecular*
             • DNA-Binding Proteins • Electrophoresis •
             Endometrium • Enhancer Elements, Genetic •
             Epithelial Cells • Estrogen Receptor alpha •
             Female • Gene Deletion • Interferon Regulatory
             Factor-2 • Interferon Type I • Mutation •
             Pregnancy Proteins • Promoter Regions, Genetic •
             Receptors, Estrogen • Recombinant Proteins •
             Repressor Proteins* • Sheep • Thymidine Kinase
             • Transcription Factors* • Transcription, Genetic
             • cytology • drug effects • genetics •
             genetics* • metabolism • metabolism* •
             pharmacology • physiology*},
   Abstract = {Interferon-tau (IFNtau), the ruminant pregnancy recognition
             signal, inhibits transcription of the estrogen receptor
             alpha (ERalpha) gene in the endometrial lumenal epithelium
             of the sheep uterus, thereby abrogating production of
             luteolytic PGF(2alpha) pulses. The effects of IFNtau are
             mediated in part by IFN-stimulated response elements (ISREs)
             and IFN regulatory factor elements (IRFEs). The
             promoter/enhancer region of the ovine ERalpha gene was
             cloned, sequenced, and predicted to contain four IRFEs and
             one ISRE. Electrophoretic mobility shift assays indicated
             that the -2110 IRFE bound only IRF-1, whereas the -1877 IRFE
             and the -1284 ISRE were functional in binding IRF-1 and
             IRF-2. IFNtau inhibited transcriptional activity of the
             2.7-kb ovine ERalpha promoter in transfection assays using
             ovine lumenal epithelium cells. Analyses of sequential
             5'-deletion mutants of the ovine ERalpha promoter indicated
             that the effects of IFNtau may be mediated by IRFEs as well
             as other elements. Overexpression of ovine IRF-2, but not
             IRF-1, inhibited transcriptional activity of several regions
             of the ovine ERalpha promoter containing an IRFE or an ISRE
             as well as some, but not all, regions lacking these
             elements.},
   Language = {eng},
   Key = {fds174194}
}

@booklet{Johnson01,
   Author = {G. A. Johnson and F. W. Bazer and L. A. Jaeger and H. Ka and J. E. Garlow and C. Pfarrer and T. E. Spencer and R. C.
             Burghardt},
   Title = {Muc-1, integrin, and osteopontin expression during the
             implantation cascade in sheep},
   Journal = {Biology Of Reproduction},
   Volume = {65},
   Number = {3},
   Pages = {820 -- 828},
   Year = {2001},
   Month = {September},
   Key = {Johnson01}
}

@booklet{Scribner01a,
   Author = {D. R. Scribner and J. L. Walker and G. A. Johnson and S. D.
             Mcmeekin and M. A. Gold and R. S. Mannel},
   Title = {Laparoscopic pelvic and paraaortic lymph node dissection:
             Analysis of the first 100 cases},
   Journal = {Gynecologic Oncology},
   Volume = {82},
   Number = {3},
   Pages = {498 -- 503},
   Year = {2001},
   Month = {September},
   Key = {Scribner01a}
}

@article{fds174103,
   Author = {GA Johnson and FW Bazer and LA Jaeger and H Ka and JE Garlow and C Pfarrer and TE Spencer and RC Burghardt},
   Title = {Muc-1, integrin, and osteopontin expression during the
             implantation cascade in sheep.},
   Journal = {Biology of reproduction},
   Volume = {65},
   Number = {3},
   Pages = {820-8},
   Year = {2001},
   Month = {September},
   ISSN = {0006-3363},
   Keywords = {Actinin • Animals • Cell Adhesion •
             Cytoskeleton • Embryo Implantation • Endometrium
             • Epithelium • Estrous Cycle • Female •
             Fluorescent Antibody Technique • Gestational Age •
             Immunohistochemistry • Integrins • Interferon Type
             I • Mucin-1 • Osteopontin • Pregnancy •
             Pregnancy Proteins • RNA, Messenger • Recombinant
             Proteins • Reverse Transcriptase Polymerase Chain
             Reaction • Sheep • Sialoglycoproteins • Talin
             • Trophoblasts • Uterus • analysis •
             analysis* • chemistry • genetics • genetics*
             • pharmacology • physiology •
             physiology*},
   Abstract = {The extracellular matrix protein osteopontin (OPN) is a
             component of histotroph that increases in uterine flushings
             from pregnant ewes during the peri-implantation period and
             is localized on the apical surfaces of the uterine luminal
             epithelium (LE) and conceptus trophectoderm (Tr). The
             potential involvement of OPN in the implantation adhesion
             cascade in sheep was investigated by examining temporal,
             spatial, and potential functional relationships between OPN,
             Muc-1, and integrin subunits during the estrous cycle and
             early pregnancy. Immunoreactive Muc-1 was highly expressed
             at the apical surfaces of uterine luminal (LE) and glandular
             epithelium (GE) in both cycling and pregnant ewes but was
             decreased dramatically on LE by Day 9 and was nearly
             undetectable by Day 17 of pregnancy when intimate contact
             between LE and Tr begins. In contrast, integrin subunits
             alpha(v), alpha(4), alpha(5), beta(1), beta(3), and beta(5)
             were constitutively expressed on conceptus Tr and at the
             apical surface of uterine LE and GE in both cyclic and early
             pregnant ewes. The apical expression of these subunits could
             contribute to the apical assembly of several OPN receptors
             including the alpha(v)beta(3), alpha(v)beta(1),
             alpha(v)beta(5), alpha(4)beta(1), and alpha(5)beta(1)
             heterodimers on endometrial LE and GE, and conceptus Tr in
             sheep. Functional analysis of potential OPN interactions
             with conceptus and endometrial integrins was performed on LE
             and Tr cells in vitro using beads coated with OPN,
             poly-L-lysine, or recombinant OPN in which the Arg-Gly-Asp
             sequence was replaced with RGE or RAD. Transmembrane
             accumulation of talin or alpha-actinin at the apical surface
             of uterine LE and conceptus Tr cells in contact with
             OPN-coated beads revealed functional integrin activation and
             cytoskeletal reorganization in response to OPN binding.
             These results provide a physiological framework for the role
             of OPN, a potential mediator of implantation in sheep, as a
             bridge between integrin heterodimers expressed by Tr and
             uterine LE responsible for adhesion for initial conceptus
             attachment.},
   Language = {eng},
   Key = {fds174103}
}

@article{fds174212,
   Author = {DR Scribner Jr and JL Walker and GA Johnson and SD McMeekin and MA Gold and RS Mannel},
   Title = {Laparoscopic pelvic and paraaortic lymph node dissection:
             analysis of the first 100 cases.},
   Journal = {Gynecologic oncology},
   Volume = {82},
   Number = {3},
   Pages = {498-503},
   Year = {2001},
   Month = {September},
   ISSN = {0090-8258},
   url = {http://dx.doi.org/10.1006/gyno.2001.6314},
   Keywords = {Adult • Aged • Aged, 80 and over • Aorta,
             Thoracic • Endometrial Neoplasms • Female •
             Humans • Laparoscopy • Lymph Node Excision •
             Middle Aged • Neoplasm Staging • Ovarian Neoplasms
             • Pelvis • Retrospective Studies • adverse
             effects • methods* • pathology •
             surgery*},
   Abstract = {OBJECTIVE: The aim of this study was to analyze the first
             100 cases of planned laparoscopic pelvic and paraaortic
             lymph node dissection (LND) done for staging of gynecologic
             cancers. The goal of the study was to assess prognostic
             factors for conversion to laparotomy and document
             complications. METHODS: A retrospective review of patients
             who had planned laparoscopic bilateral pelvic and bilateral
             paraaortic LND for staging of their gynecologic cancer was
             performed. Patients were identified by our institutional
             database and data were collected by review of their medical
             records. Data were obtained regarding demographics, stage,
             histology, length of stay, and procedural information
             including completion rates, operating room time, estimated
             blood loss, assistant, lymph node count, and complications.
             Associations between variables were analyzed using Student t
             tests, analysis of variance, and chi(2) testing (Excel
             v7.0). RESULTS: A total of 103 patients were identified from
             12/15/95 to 8/28/00. Demographics included mean age of 66.2
             (25-92) and mean Quetelet index (QI) of 30.8 (15.9-56.1). A
             total of 34/103 (33.0%) had > or =1 previous laparotomy.
             Ninety-five patients had endometrial cancer and 8 had
             ovarian cancer. Eighty-six of 103 (83.5%) were stage I or
             II. The length of stay was shorter for those who had
             laparoscopy than for those who needed conversion to
             laparotomy (2.8 vs 5.6 days, P < 0.0001). Laparoscopy was
             completed in 73/103 (70.9%) of the cases. Completion rates
             were 62/76 (81.6%) with QI < 35 vs 11/27 (40.7%) with QI >
             or = 35, P < 0.001. Significantly more patients had their
             laparoscopy completed when an attending gynecologic
             oncologist was the first assistant compared to a fellow or a
             community obstetrician/gynecologist (92.9%, 69.0%, 64.5%, P
             < 0.0001). The top three reasons for conversion to
             laparotomy were obesity, 12/30 (29.1%), adhesions, 5/30
             (16.7%), and intraperitoneal disease, 5/30 (16.7%). Pelvic,
             common iliac, and paraaortic lymph node counts did not
             differ when compared to those of patients who had conversion
             to laparotomy (18.1, 5.1, 6.8 vs 17.3, 5.7, 6.8, P = ns).
             Complications included 2 urinary tract injuries, 2 pulmonary
             embolisms, and 6 wound infections (all in the laparotomy
             group). Two deaths occurred, 1 due to a vascular injury on
             initial trocar insertion and 1 due to a pulmonary embolism
             after a laparotomy for bowel herniation through a trocar
             incision. CONCLUSION: Laparoscopic bilateral pelvic and
             paraaortic LND can be completed successfully in 70.9% of
             patients. Age, obesity, previous surgery, and the need to
             perform this procedure in the community were not
             contraindications. Advantages include a shorter hospital
             stay, similar nodal counts, and acceptable
             complications.},
   Language = {eng},
   Doi = {10.1006/gyno.2001.6314},
   Key = {fds174212}
}

@booklet{Choi01,
   Author = {Y. S. Choi and G. A. Johnson and R. C. Burghardt and L. R.
             Berghman and M. M. Joyce and K. M. Taylor and M. D. Stewart and F. W. Bazer and T. E. Spencer},
   Title = {Interferon regulatory factor-two restricts expression of
             interferon-stimulated genes to the endometrial stroma and
             glandular epithelium of the ovine uterus},
   Journal = {Biology Of Reproduction},
   Volume = {65},
   Number = {4},
   Pages = {1038 -- 1049},
   Year = {2001},
   Month = {October},
   Key = {Choi01}
}

@article{fds174124,
   Author = {Y Choi and GA Johnson and RC Burghardt and LR Berghman and MM Joyce and KM
             Taylor, MD Stewart and FW Bazer and TE Spencer},
   Title = {Interferon regulatory factor-two restricts expression of
             interferon-stimulated genes to the endometrial stroma and
             glandular epithelium of the ovine uterus.},
   Journal = {Biology of reproduction},
   Volume = {65},
   Number = {4},
   Pages = {1038-49},
   Year = {2001},
   Month = {October},
   ISSN = {0006-3363},
   Keywords = {Animals • DNA-Binding Proteins • Endometrium
             • Epithelium • Estrous Cycle • Female •
             Fluorescent Antibody Technique • Gene Expression*
             • Interferon Regulatory Factor-1 • Interferon
             Regulatory Factor-2 • Interferon Type I •
             Interferon-Stimulated Gene Factor 3 • Interferons
             • Phosphoproteins • Pregnancy Proteins •
             Promoter Regions, Genetic • RNA, Messenger •
             Recombinant Proteins • Repressor Proteins* • STAT1
             Transcription Factor • STAT2 Transcription Factor
             • Sheep* • Stromal Cells • Trans-Activators
             • Transcription Factors • Transcriptional
             Activation • Transfection • Uterus • analysis
             • drug effects • genetics • metabolism •
             metabolism* • pharmacology • pharmacology* •
             physiology • physiology*},
   Abstract = {Interferon tau (IFNtau) is the signal for maternal
             recognition of pregnancy in ruminants. The positive effects
             of IFNtau on IFN-stimulated gene (ISG) expression are
             mediated by ISG factor 3 (ISGF3), which is composed of
             signal transducer and activator of transcription (Stat) 1,
             Stat 2, and IFN regulatory factor-9 (IRF-9), and by
             gamma-activated factor (GAF), which is a Stat 1 homodimer.
             Induction of ISGs, such as ISG17 and 2',5'-oligoadenylate
             synthetase, by IFNtau during pregnancy is limited to the
             endometrial stroma (S) and glandular epithelium (GE) of the
             ovine uterus. The IRF-2, a potent transcriptional repressor
             of ISG expression, is expressed in the luminal epithelium
             (LE). This study determined effects of the estrous cycle,
             pregnancy, and IFNtau on expression of Stat 1, Stat 2,
             IRF-9, IRF-1, and IRF-2 genes in the ovine endometrium. In
             cyclic ewes, Stat 1, Stat 2, IRF-1, and IRF-9 mRNA and
             protein were detected at low levels in the S and GE. During
             pregnancy, expression of these genes increased only in the S
             and GE. Expression of IRF-2 was detected only in the LE and
             superficial GE (sGE) of both cyclic and pregnant ewes. In
             cyclic ewes, intrauterine administration of IFNtau
             stimulated Stat 1, Stat 2, IRF-9, and IRF-1 expression in
             the endometrium. Ovine IRF-2 repressed transcriptional
             activity driven by IFN-stimulated response elements that
             bind ISGF3, but not by gamma-activation sequences that bind
             GAF. These results suggest that IRF-2 in the LE and sGE
             restricts IFNtau induction of ISGs to the S and GE. In the S
             and GE, IFNtau hyperactivation of ISG expression likely
             involves formation and actions of the transcription factors
             ISGF3 and, perhaps, IRF-1.},
   Language = {eng},
   Key = {fds174124}
}

@booklet{Gray01,
   Author = {C. A. Gray and F. F. Bartol and B. J. Tarleton and A. A.
             Wiley and G. A. Johnson and F. W. Bazer and T. E.
             Spencer},
   Title = {Developmental biology of uterine glands},
   Journal = {Biology Of Reproduction},
   Volume = {65},
   Number = {5},
   Pages = {1311 -- 1323},
   Year = {2001},
   Month = {November},
   Key = {Gray01}
}

@booklet{Frush01,
   Author = {Frush, DP and Yoshizumi, TT and Paulson, EK and Johnson,
             GA},
   Title = {Radiation dose from helical CT in children: Comparison of
             multi-slice and single-slice protocols},
   Journal = {Radiology},
   Volume = {221},
   Pages = {246-246},
   Year = {2001},
   Month = {November},
   ISSN = {0033-8419},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000172126600589&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Frush01}
}

@booklet{Paulson01,
   Author = {Paulson, EK and Yoshizumi, TT and Frush, DP and Johnson,
             GA},
   Title = {Multi-detector vs single-detector CT: The organ doses are
             higher than you think},
   Journal = {Radiology},
   Volume = {221},
   Pages = {403-403},
   Year = {2001},
   Month = {November},
   ISSN = {0033-8419},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000172126601192&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Paulson01}
}

@booklet{Tengowski01,
   Author = {Tengowski, MW and Suddarth, SA and Cofer, GP and Wheeler, CT and Botts,
             S and Fasulo, LM and Jeffries-Griffor, JL and Amacher, DE and Lawton,
             MP and Hedlund, LW and Zhang, XW and Burkhardt, JE and Johnson,
             GA},
   Title = {Using technology to develop a hepatic lipidosis blomarker in
             the rat},
   Journal = {Molecular Biology of the Cell},
   Volume = {12},
   Pages = {261A-261A},
   Year = {2001},
   Month = {November},
   ISSN = {1059-1524},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000172372501425&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Tengowski01}
}

@article{fds174253,
   Author = {CA Gray and FF Bartol and BJ Tarleton and AA Wiley and GA Johnson and FW
             Bazer, TE Spencer},
   Title = {Developmental biology of uterine glands.},
   Journal = {Biology of reproduction},
   Volume = {65},
   Number = {5},
   Pages = {1311-23},
   Year = {2001},
   Month = {November},
   ISSN = {0006-3363},
   Keywords = {Animals • Endometrium • Estradiol • Female
             • Humans • Morphogenesis • Prolactin •
             Receptors, Estradiol • Receptors, Prolactin •
             Uterus • embryology • embryology* •
             physiology},
   Abstract = {All mammalian uteri contain endometrial glands that
             synthesize or transport and secrete substances essential for
             survival and development of the conceptus (embryo/fetus and
             associated extraembryonic membranes). In rodents, uterine
             secretory products of the endometrial glands are
             unequivocally required for establishment of uterine
             receptivity and conceptus implantation. Analyses of the
             ovine uterine gland knockout model support a primary role
             for endometrial glands and, by default, their secretions in
             peri-implantation conceptus survival and development.
             Uterine adenogenesis is the process whereby endometrial
             glands develop. In humans, this process begins in the fetus,
             continues postnatally, and is completed during puberty. In
             contrast, endometrial adenogenesis is primarily a postnatal
             event in sheep, pigs, and rodents. Typically, endometrial
             adenogenesis involves differentiation and budding of
             glandular epithelium from luminal epithelium, followed by
             invagination and extensive tubular coiling and branching
             morphogenesis throughout the uterine stroma to the
             myometrium. This process requires site-specific alterations
             in cell proliferation and extracellular matrix (ECM)
             remodeling as well as paracrine cell-cell and cell-ECM
             interactions that support the actions of specific hormones
             and growth factors. Studies of uterine development in
             neonatal ungulates implicate prolactin, estradiol-17 beta,
             and their receptors in mechanisms regulating endometrial
             adenogenesis. These same hormones appear to regulate
             endometrial gland morphogenesis in menstruating primates and
             humans during reconstruction of the functionalis from the
             basalis endometrium after menses. In sheep and pigs,
             extensive endometrial gland hyperplasia and hypertrophy
             occur during gestation, presumably to provide increasing
             histotrophic support for conceptus growth and development.
             In the rabbit, sheep, and pig, a servomechanism is proposed
             to regulate endometrial gland development and differentiated
             function during pregnancy that involves sequential actions
             of ovarian steroid hormones, pregnancy recognition signals,
             and lactogenic hormones from the pituitary or placenta. That
             disruption of uterine development during critical
             organizational periods can alter the functional capacity and
             embryotrophic potential of the adult uterus reinforces the
             importance of understanding the developmental biology of
             uterine glands. Unexplained high rates of peri-implantation
             embryonic loss in humans and livestock may reflect defects
             in endometrial gland morphogenesis due to genetic errors,
             epigenetic influences of endocrine disruptors, and
             pathological lesions.},
   Language = {eng},
   Key = {fds174253}
}

@booklet{Scribner01,
   Author = {D. R. Scribner and J. L. Walker and G. A. Johnson and S. D.
             Mcmeekin and M. A. Gold and R. S. Mannel},
   Title = {Surgical management of early-stage endometrial cancer in the
             elderly: Is laparoscopy feasible?},
   Journal = {Gynecologic Oncology},
   Volume = {83},
   Number = {3},
   Pages = {563 -- 568},
   Year = {2001},
   Month = {December},
   Key = {Scribner01}
}

@article{fds174187,
   Author = {DR Scribner Jr and JL Walker and GA Johnson and SD McMeekin and MA Gold and RS Mannel},
   Title = {Surgical management of early-stage endometrial cancer in the
             elderly: is laparoscopy feasible?},
   Journal = {Gynecologic oncology},
   Volume = {83},
   Number = {3},
   Pages = {563-8},
   Year = {2001},
   Month = {December},
   ISSN = {0090-8258},
   url = {http://dx.doi.org/10.1006/gyno.2001.6463},
   Keywords = {Aged • Aged, 80 and over • Endometrial Neoplasms
             • Female • Humans • Hysterectomy, Vaginal
             • Laparoscopy • Lymph Node Excision •
             Neoplasm Staging • Retrospective Studies •
             methods* • pathology • surgery*},
   Abstract = {OBJECTIVE: To give insight into the utility of laparoscopic
             staging of endometrial cancer in the elderly population by
             reviewing the surgical management of clinically stage I
             endometrial cancer patients. METHODS: A retrospective
             analysis evaluating patients that were > or =65 years old
             and had planned laparoscopic staging, traditional staging
             via a laparotomy, or a transvaginal hysterectomy as
             management of their early endometrial cancer. The
             laparoscopic group had complete staging with bilateral
             pelvic and paraaortic lymph node dissections and was
             compared to the group who had staging performed via
             laparotomy. Patients were identified by our institution's
             database and data were collected by review of their medical
             records. Data were collected on demographics, pathology, and
             procedural information including completion rates, operating
             room (OR) time, estimated blood loss (EBL), transfusions,
             lymph node count, complications, and length of stay.
             Associations between variables were analyzed by Student's t
             tests and chi(2) testing using Excel v. 9.0. RESULTS: From
             February 25, 1994, through December 21, 2000, 125 elderly
             patients were identified. Sixty-seven patients had planned
             laparoscopic staging (Group 1), 45 patients had staging via
             planned laparotomy (Group 2), and 13 patients had a
             transvaginal hysterectomy (Group 3). Group 1 and Group 2
             were compared regarding surgical and postoperative data. Age
             was not different between these groups (75.9 vs 74.7 years,
             P = NS). Quetelet index was also similar (29.4 vs 29.9, P =
             NS) 32.8% of Group 1 had > or =1 previous laparotomy
             compared to 51.1% in Group 2 (P = NS). In Group 1, 53/67
             (79.1%) had stage I or II disease compared to 29/45 (64.4%)
             in Group 2 (P = NS). Laparoscopy was completed in 52/67
             (77.6%) attempted procedures. The reasons for conversion to
             laparotomy were obesity 7/67 (10.4%), bleeding 4/67 (6.0%),
             intraperitoneal cancer 3/67 (4.5%), and adhesions 1/67
             (1.5%). OR time was significantly longer in successful Group
             1 patients compared to Group 2 patients (236 vs 148 min, p =
             0.0001). EBL was similar between these groups (298 vs 336
             ml, P = NS). Ten of 52 (19.2%) of successful Group 1
             patients received a blood transfusion compared to 1/45
             (2.2%) of Group 2 patients (P < 0.0001). Pelvic, common
             iliac, and paraaortic lymph node counts were similar between
             successful Group 1 patients and those in Group 2 combined
             with those that received a laparotomy in Group 1 (17.8, 5.2,
             6.6 vs 19.1, 5.1, 5.2, P = NS). Length of stay (LOS) was
             significantly shorter in Group 1 versus Group 2 (3.0 vs 5.8
             days, P < 0.0001). There were less fevers (6.0 vs 15.6%, P =
             0.01), less postoperative ileus's (0 vs 15.6%, P < 0.001),
             and less wound complications (6.0 vs 26.7%, P = 0.002) in
             Group 1 compared to Group 2. Group 3 average age was 77.5
             years. Concurrent medical comorbidities were the main reason
             for the transvaginal approach. OR time averaged 104.5 min.
             The average length of stay was 2.1 days with no procedural
             or postoperative complications. CONCLUSIONS: The favorable
             results from this retrospective study refute the bias that
             age is a relative contraindication to laparoscopic surgery.
             Laparoscopic staging was associated with an increased OR
             time and an increased rate of transfusion but equivalent
             blood loss and lymph node counts. Possible advantages are
             decreased length of stay, less postoperative ileus, and less
             infections complications. Transvaginal hysterectomy still
             remains a proven option for women with serious comorbid
             medical problems with short OR times, minimal complications,
             and short lengths of stay.},
   Language = {eng},
   Doi = {10.1006/gyno.2001.6463},
   Key = {fds174187}
}

@booklet{Johnson02b,
   Author = {G. A. Johnson and T. R. Hoverstad},
   Title = {Effect of row spacing and herbicide application timing on
             weed control and grain yield in corn (Zea
             mays)},
   Journal = {Weed Technology},
   Volume = {16},
   Number = {3},
   Pages = {548 -- 553},
   Year = {2002},
   Key = {Johnson02b}
}

@article{fds174284,
   Author = {RC Burghardt and GA Johnson and LA Jaeger and H Ka and JE Garlow and TE
             Spencer, FW Bazer},
   Title = {Integrins and extracellular matrix proteins at the
             maternal-fetal interface in domestic animals.},
   Journal = {Cells, tissues, organs},
   Volume = {172},
   Number = {3},
   Pages = {202-17},
   Year = {2002},
   ISSN = {1422-6405},
   Keywords = {Animals • Embryo Implantation • Endometrium •
             Extracellular Matrix Proteins • Female • Humans
             • Integrins • Maternal-Fetal Exchange* •
             Osteopontin • Peptide Fragments • Placenta •
             Pregnancy • Protein Precursors • Sheep •
             Sialoglycoproteins • Swine • Transforming Growth
             Factor beta1 • cytology • genetics •
             metabolism • metabolism* • physiology •
             physiology*},
   Abstract = {Establishment of pregnancy in mammals requires coordinated
             conceptus-maternal interactions involving numerous hormones,
             growth factors and cytokines acting via specific receptors
             in the uterus. Uterine secretions play an important role in
             establishing synchrony between development of the conceptus
             and uterine receptivity, as well as in conceptus remodeling,
             adhesion, implantation and placentation in domestic species.
             Studies of non-invasive implantation in domestic livestock
             provide valuable opportunities to investigate fundamental
             processes of the initial events of apposition, attachment
             and adhesive interactions that are shared among species. In
             pigs and sheep, it appears that integrins play a dominant
             role in these fundamental processes via interactions with
             extracellular matrix molecules and other ligands to
             transduce cellular signals in uterine epithelial cells and
             conceptus trophectoderm. This review considers several of
             the potential integrin-binding ligands involved in the
             complex implantation adhesion cascade in pigs and sheep
             along with in vitro evidence for the transduction of
             cytoplasmic signals that may be required to sustain fetal
             and maternal contributions to the formation of the
             epitheliochorial placenta.},
   Language = {eng},
   Key = {fds174284}
}

@article{fds174305,
   Author = {SC Walker and T Shin and GM Zaunbrecher and JE Romano and GA Johnson and FW
             Bazer, JA Piedrahita},
   Title = {A highly efficient method for porcine cloning by nuclear
             transfer using in vitro-matured oocytes.},
   Journal = {Cloning and stem cells},
   Volume = {4},
   Number = {2},
   Pages = {105-12},
   Year = {2002},
   ISSN = {1536-2302},
   url = {http://dx.doi.org/10.1089/153623002320253283},
   Keywords = {Animals • Cloning, Organism • Culture Techniques
             • Embryo Transfer • Female • Microsatellite
             Repeats • Nuclear Transfer Techniques* • Oocytes
             • Pregnancy • Sex Ratio • Swine •
             cytology* • genetics • genetics* •
             methods*},
   Abstract = {To date, the efficiency of pig cloning by nuclear transfer
             of somatic cell nuclei has been extremely low, with less
             than 1% of transferred embryos surviving to term. Even the
             utilization of complex procedures such as two rounds of
             nuclear transfer has not resulted in greater overall
             efficiencies. As a result, the applicability of the
             technology for the generation of transgenic and cloned
             animals has not moved forward rapidly. We report here a
             simple nuclear transfer protocol, utilizing commercially
             available in vitro-matured oocytes, that results in greater
             than 5% overall cloning efficiency. Of five recipients
             receiving nuclear transfer embryos produced with a fetal
             fibroblast cell line as nuclear donor, all five established
             pregnancies by day 28 (100%), and 4/5 (80%) went to term.
             Efficiencies for each transfer were 7% (9 piglets/128
             doublets transferred), 5% (5/100), 12% (7/59), and 6.6%
             (7/106). The overall efficiency in all recipients was 5.5%
             and in pregnant recipients 7.7%, with a total of 28 cloned
             piglets produced. With the average fusion rate being 58%,
             the percentage of fused doublets producing a live piglet
             approached 12%. The method described here can be undertaken
             by a single micromanipulator at a reasonable cost, and
             should facilitate the broad utilization of porcine cloning
             technology in transgenic and nontransgenic
             applications.},
   Language = {eng},
   Doi = {10.1089/153623002320253283},
   Key = {fds174305}
}

@article{fds268752,
   Author = {Johnson, GA and Cofer, GP and Gewalt, SL and Hedlund, LW and IEEE, and IEEE},
   Title = {An engineering approach to image-based phenotyping},
   Journal = {2002 IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING,
             PROCEEDINGS},
   Pages = {381-383},
   Year = {2002},
   ISBN = {0-7803-7584-X},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000178000400095&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {fds268752}
}

@article{fds268887,
   Author = {Hedlund, LW and Johnson, GA},
   Title = {Mechanical ventilation for imaging the small animal
             lung.},
   Journal = {ILAR Journal},
   Volume = {43},
   Number = {3},
   Pages = {159-174},
   Year = {2002},
   ISSN = {1084-2020},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/12105383},
   Keywords = {Anatomy, Cross-Sectional • Animals • Animals,
             Laboratory • Disease Models, Animal • Guinea Pigs
             • Lung* • Magnetic Resonance Imaging • Rats
             • Respiration, Artificial • anatomy & histology
             • instrumentation • methods* • physiology
             • physiology* • physiopathology},
   Abstract = {This review emphasizes some of the challenges and benefits
             of in vivo imaging of the small animal lung. Because
             mechanical ventilation plays a key role in high-quality,
             high-resolution imaging of the small animal lung, the
             article focuses particularly on the problems of ventilation
             support, control of breathing motion and lung volume, and
             imaging during different phases of the breathing cycle.
             Solutions for these problems are discussed primarily in
             relation to magnetic resonance imaging, both conventional
             proton imaging and the newer, hyperpolarized helium imaging
             of pulmonary airways. Examples of applications of these
             imaging solutions to normal and diseased lung are
             illustrated in the rat and guinea pig. Although difficult to
             perform, pulmonary imaging in the small animal can be a
             valuable source of information not only for the normal lung,
             but also for the lung challenged by disease.},
   Key = {fds268887}
}

@booklet{Joyce02,
   Author = {M. M. Joyce and T. R. Hansen and G. A. Johnson},
   Title = {Interferon-stimulated gene 17 is expressed in the porcine
             uterus and may be critical to placental development across
             species.},
   Journal = {Biology Of Reproduction},
   Volume = {66},
   Pages = {185 -- 186},
   Year = {2002},
   Key = {Joyce02}
}

@booklet{Johnson02d,
   Author = {G. A. Johnson and M. M. Joyce and R. C. Burghardt},
   Title = {Osteopontin/early T-cell activation factor-1 is expressed by
             fetal placental immune cells after day 20 of pregnancy in
             sheep but not pigs.},
   Journal = {Biology Of Reproduction},
   Volume = {66},
   Pages = {272 -- 273},
   Year = {2002},
   Key = {Johnson02d}
}

@booklet{Hartt02,
   Author = {L. S. Hartt and M. M. Joyce and S. J. Sinor and H. Z. Liu and G. A. Johnson and D. K. Vanderwall and T. L.
             Ott},
   Title = {Temporal and spatial regulation of estrogen receptor a (ER)
             and progesterone receptor (PR) expression in the endometrium
             of nonpregnant and early pregnant mares.},
   Journal = {Biology Of Reproduction},
   Volume = {66},
   Pages = {316 -- 316},
   Year = {2002},
   Key = {Hartt02}
}

@booklet{Burghardt02,
   Author = {R. C. Burghardt and G. A. Johnson and L. A. Jaeger and H. Ka and J. E. Garlow and T. E. Spencer and F. W.
             Bazer},
   Title = {Integrins and extracellular matrix proteins at the
             maternal-fetal interface in domestic animals},
   Journal = {Cells Tissues Organs},
   Volume = {172},
   Number = {3},
   Pages = {202 -- 217},
   Year = {2002},
   Key = {Burghardt02}
}

@booklet{Sinor02,
   Author = {S. J. Sinor and M. M. Joyce and S. J. Yankey and A. M.
             Assiri and K. Kodali and L. S. Hartt and M. Robison and G.
             A. Johnson and T. L. Ott},
   Title = {Mx, estrogen receptor (ER), and progesterone receptor (PR)
             expression in ovine placentomal and interplacentomal
             endometrium during days 25 to 120 of pregnancy.},
   Journal = {Biology Of Reproduction},
   Volume = {66},
   Pages = {244 -- 244},
   Year = {2002},
   Key = {Sinor02}
}

@booklet{Pfarrer02,
   Author = {C. D. Pfarrer and S. Hallack and G. A. Johnson and R. C.
             Burghardt and F. W. Bazer and R. Leiser},
   Title = {Expression of osteopontin in bovine placentomes and
             interplacentomal areas from early placentation until
             term.},
   Journal = {Biology Of Reproduction},
   Volume = {66},
   Pages = {229 -- 230},
   Year = {2002},
   Key = {Pfarrer02}
}

@booklet{Al-ramadan02,
   Author = {S. Y. Al-ramadan and G. A. Johnson and L. A. Jaeger and S.
             P. Brinsko and R. C. Burghardt},
   Title = {Distribution of integrin subunits, MUC-1, and osteopontin in
             equine uterine epithelium and conceptuses during early
             pregnancy.},
   Journal = {Biology Of Reproduction},
   Volume = {66},
   Pages = {323 -- 323},
   Year = {2002},
   Key = {Al-ramadan02}
}

@article{fds292761,
   Author = {Spielmann, AL and Nelson, RC and Lowry, CR and Johnson, GA and Sundaramoothy, G and Sheafor, DH and Paulson, EK},
   Title = {Liver: single breath-hold dynamic subtraction CT with
             multi-detector row helical technology feasibility
             study.},
   Journal = {Radiology},
   Volume = {222},
   Number = {1},
   Pages = {278-283},
   Year = {2002},
   Month = {January},
   ISSN = {0033-8419},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/11756737},
   Keywords = {Adult • Aged • Feasibility Studies • Female
             • Humans • Liver Neoplasms • Male •
             Middle Aged • Neovascularization, Pathologic •
             Prospective Studies • Subtraction Technique •
             Tomography, X-Ray Computed • methods* •
             radiography • radiography* • secondary},
   Abstract = {Fifty-two patients with known or suspected hypervascular
             malignancy were examined to determine the technical
             feasibility of performing single-breath-hold dynamic
             subtraction computed tomography (CT) of the liver with
             multi-detector row helical CT. The precontrast and hepatic
             arterial CT scans, which were acquired during the same
             breath hold, were subtracted. The mean liver-to-muscle
             contrast ratio on the precontrast, hepatic arterial, and
             subtracted images was 1.3, 1.4, and 2.3, respectively. In 13
             patients with lesions, the subtracted images showed a
             2.5-fold increase in mean lesion contrast compared with the
             hepatic arterial CT scans.},
   Language = {eng},
   Doi = {10.1148/radiol.2221010190},
   Key = {fds292761}
}

@booklet{Brau02,
   Author = {A. C. S. Brau and C. T. Wheeler and L. W. Hedlund and G. A.
             Johnson},
   Title = {Fiber-optic stethoscope: A cardiac monitoring and gating
             system for magnetic resonance microscopy},
   Journal = {Magnetic Resonance In Medicine},
   Volume = {47},
   Number = {2},
   Pages = {314 -- 321},
   Year = {2002},
   Month = {February},
   Key = {Brau02}
}

@booklet{Stewart02,
   Author = {M. D. Stewart and Y. S. Choi and G. A. Johnson and L. Y.
             Yu-lee and F. W. Bazer and T. E. Spencer},
   Title = {Roles of Stat1, Stat2, and interferon regulatory factor-9
             (IRF-9) in interferon tau regulation of IRF-1},
   Journal = {Biology Of Reproduction},
   Volume = {66},
   Number = {2},
   Pages = {393 -- 400},
   Year = {2002},
   Month = {February},
   Key = {Stewart02}
}

@booklet{Gupta02,
   Author = {Gupta, AK and Johnson, GA and Nelson, RC},
   Title = {Optimization of eight-element multi-detector helical CT for
             imaging the abdomen},
   Journal = {Radiology},
   Volume = {222},
   Number = {2},
   Pages = {589-589},
   Year = {2002},
   Month = {February},
   Key = {Gupta02}
}

@article{fds174192,
   Author = {MD Stewart and Y Choi and GA Johnson and LY Yu-Lee and FW Bazer and TE
             Spencer},
   Title = {Roles of Stat1, Stat2, and interferon regulatory factor-9
             (IRF-9) in interferon tau regulation of IRF-1.},
   Journal = {Biology of reproduction},
   Volume = {66},
   Number = {2},
   Pages = {393-400},
   Year = {2002},
   Month = {February},
   ISSN = {0006-3363},
   Keywords = {Blotting, Western • Cell Line • Cells, Cultured
             • DNA-Binding Proteins • Fibroblasts • Humans
             • Indicators and Reagents • Interferon Regulatory
             Factor-1 • Interferon Type I •
             Interferon-Stimulated Gene Factor 3 •
             Interferon-Stimulated Gene Factor 3, gamma Subunit •
             Phosphoproteins • Phosphorylation • Pregnancy
             Proteins • RNA, Messenger • Reverse Transcriptase
             Polymerase Chain Reaction • STAT1 Transcription Factor
             • STAT2 Transcription Factor • Signal Transduction
             • Trans-Activators • Transcription Factors •
             Tyrosine • biosynthesis • genetics •
             metabolism • physiology • physiology*},
   Abstract = {Interferon tau (IFNtau) is the pregnancy recognition signal
             produced by the conceptus trophectoderm and acts in a
             paracine manner on the ovine endometrium to increase
             expression of IFN-stimulated genes primarily in the stroma
             and deep glandular epithelium, including IFN regulatory
             factor-1 (IRF-1). The roles of Stat1, Stat2, and IRF-9 in
             IFNtau regulation of IRF-1 expression were determined using
             human stromal fibroblasts lacking specific IFN signaling
             components or complemented with specific Stat1 mutants. In
             parental (2fTGH) cells treated with IFNtau, Stat1alpha/beta
             was tyrosine phosphorylated by 15 min, and IRF-1 mRNA and
             protein increased from 0 to 6 h, was maximal at 6 h, and
             decreased to 24 h. In contrast, IFNtau did not affect IRF-1
             expression in Stat1- and Stat2-deficient cells or in
             Stat1-deficient cells complemented with Stat1 Y701Q or Stat1
             R602L mutants. In Stat1-deficient cells complemented with
             the Stat1 S727A mutant, Stat1alpha, or Stat1beta and treated
             with IFNtau, IRF-1 increased from 0 to 6 h, was maximal at 6
             h, and decreased thereafter. In IRF-9-deficient cells
             stimulated with IFNtau, IRF-1 increased from 0 to 6 h but
             did not exhibit the sharp decline from 6 to 12 h observed in
             other cells. Collectively, results indicate that IFNtau
             effect on IRF-1 expression is primarily regulated by
             tyrosine-phosphorylated Stat1alpha or Stat1beta dimers,
             whereas the decline of IRF-1 after 6 h of IFNtau treatment
             is regulated by IRF-9.},
   Language = {eng},
   Key = {fds174192}
}

@article{fds269015,
   Author = {Brau, ACS and Wheeler, CT and Hedlund, LW and Johnson,
             GA},
   Title = {Fiber-optic stethoscope: a cardiac monitoring and gating
             system for magnetic resonance microscopy.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {47},
   Number = {2},
   Pages = {314-321},
   Year = {2002},
   Month = {February},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/11810675},
   Keywords = {Animals • Electrocardiography • Esophagoscopy*
             • Fiber Optics* • Heart Atria • Heart Rate
             • Heart Ventricles • Hemodynamic Processes •
             Magnetic Resonance Imaging • Mice • Mice, Inbred
             C57BL • Microscopy • Myocardial Contraction •
             Rats • Stethoscopes* • anatomy & histology* •
             instrumentation* • physiology},
   Abstract = {A fundamental problem associated with using the conventional
             electrocardiograph (ECG) to monitor a subject's cardiac
             activity during magnetic resonance imaging (MRI) is the
             distortion of the ECG due to electromagnetic interference.
             This problem is particularly pronounced in MR microscopy
             (MRI of small animals at microscopic resolutions (< 0.03
             mm(3))) because the strong, rapidly-switching magnetic field
             gradients induce artifacts in the animal's ECG that often
             mimic electrophysiologic activity, impairing the use of the
             ECG for cardiac monitoring and gating purposes. The
             fiber-optic stethoscope system offers a novel approach to
             measuring cardiac activity that, unlike the ECG, is immune
             to electromagnetic effects. The fiber-optic stethoscope is
             perorally inserted into the esophagus of small animals to
             optically detect pulsatile compression of the esophageal
             wall. The optical system is shown to provide a robust
             cardiac monitoring and gating signal in rats and mice during
             routine cardiac MR microscopy.},
   Key = {fds269015}
}

@booklet{Scribner02,
   Author = {D. R. Scribner and J. L. Walker and G. A. Johnson and D. S.
             Mcmeekin and M. A. Gold and R. S. Mannel},
   Title = {Laparoscopic pelvic and paraaortic lymph node dissection in
             the obese},
   Journal = {Gynecologic Oncology},
   Volume = {84},
   Number = {3},
   Pages = {426 -- 430},
   Year = {2002},
   Month = {March},
   Key = {Scribner02}
}

@booklet{Garlow02,
   Author = {J. E. Garlow and H. Ka and G. A. Johnson and R. C. Burghardt and L. A. Jaeger and F. W. Bazer},
   Title = {Analysis of osteopontin at the maternal-placental interface
             in pigs},
   Journal = {Biology Of Reproduction},
   Volume = {66},
   Number = {3},
   Pages = {718 -- 725},
   Year = {2002},
   Month = {March},
   Key = {Garlow02}
}

@booklet{Johnson02g,
   Author = {G. A. Johnson and G. P. Cofer and S. L. Gewalt and L. W.
             Hedlund},
   Title = {Morphologic phenotyping with MR microscopy: The visible
             mouse},
   Journal = {Radiology},
   Volume = {222},
   Number = {3},
   Pages = {789 -- 793},
   Year = {2002},
   Month = {March},
   Key = {Johnson02g}
}

@article{fds174252,
   Author = {JE Garlow and H Ka and GA Johnson and RC Burghardt and LA Jaeger and FW
             Bazer},
   Title = {Analysis of osteopontin at the maternal-placental interface
             in pigs.},
   Journal = {Biology of reproduction},
   Volume = {66},
   Number = {3},
   Pages = {718-25},
   Year = {2002},
   Month = {March},
   ISSN = {0006-3363},
   Keywords = {Animals • Cell Membrane • Endometrium •
             Epithelial Cells • Female • Frozen Sections •
             In Situ Hybridization • Integrins • Oligopeptides
             • Osteopontin • Placenta • Pregnancy •
             RNA, Messenger • Sialoglycoproteins • Signal
             Transduction • Swine* • Trophoblasts • Uterus
             • analysis • analysis* • chemistry •
             chemistry* • genetics • metabolism •
             pharmacology • physiology},
   Abstract = {Noninvasive, epitheliochorial placentation in the pig
             follows a prolonged preimplantation period characterized by
             migration, spacing and elongation of conceptuses, and
             secretion of estrogen for maternal recognition of pregnancy.
             Osteopontin (OPN) is an extracellular matrix protein that
             binds integrins to promote cell-cell attachment and
             communication. OPN appears to play a key role in conceptus
             implantation and maintenance of pregnancy in sheep; however,
             a role for OPN in the porcine uterus has not been
             established. Therefore, this study examined OPN expression
             and function in the porcine uterus and conceptus
             (embryo/fetus and associated extraembryonic membranes).
             Northern and slot blot hybridization detected an increase in
             endometrial OPN expression between Days 25 and 30, and
             levels remained elevated through Day 85 of pregnancy. In
             situ hybridization localized OPN mRNA to discrete regions of
             the uterine luminal epithelium (LE) on Day 15 of pregnancy
             and to the entire LE thereafter. Glandular epithelial (GE)
             expression of OPN mRNA was first detected on Day 35 of
             pregnancy and increased through Day 85. Both 70- and 45-kDa
             forms of OPN protein were detected in cyclic and pregnant
             endometrium by Western blotting. OPN protein was localized
             to the LE and GE by immunofluorescence; however, only the
             70-kDa OPN was detected in uterine flushings. OPN protein
             was present along the entire uterine-placental interface
             after Day 30 of pregnancy. In addition, OPN mRNA and protein
             were localized to immune-like cells within the stratum
             compactum of the endometrium in both Day 9 cyclic and
             pregnant gilts. Incubation of OPN-coated microbeads with
             porcine trophectoderm and uterine luminal epithelial cells
             induced Arg-Gly-Asp (RGD)-dependent integrin activation and
             transmembrane accumulation of cytoskeletal molecules at the
             apical cell surface as assessed by immunofluorescence
             detection of talin or alpha-actinin as markers for focal
             adhesions. These results suggest that OPN, expressed by
             uterine epithelium and immune cells, may interact with
             receptors (i.e., integrins) on conceptus and uterus to
             promote conceptus development and signaling between these
             tissues as key contributors to attachment and placentation
             in the pig.},
   Language = {eng},
   Key = {fds174252}
}

@article{fds174296,
   Author = {DR Scribner Jr and JL Walker and GA Johnson and DS McMeekin and MA Gold and RS Mannel},
   Title = {Laparoscopic pelvic and paraaortic lymph node dissection in
             the obese.},
   Journal = {Gynecologic oncology},
   Volume = {84},
   Number = {3},
   Pages = {426-30},
   Year = {2002},
   Month = {March},
   ISSN = {0090-8258},
   url = {http://dx.doi.org/10.1006/gyno.2001.6548},
   Keywords = {Adult • Aged • Aged, 80 and over • Aorta,
             Abdominal • Endometrial Neoplasms • Female •
             Humans • Laparoscopy • Lymph Node Excision •
             Lymphatic Metastasis • Middle Aged • Obesity
             • Pelvis • Retrospective Studies •
             complications • complications* • methods •
             methods* • pathology • surgery*},
   Abstract = {OBJECTIVE: The aim of this study was to determine the
             utility of laparoscopic pelvic and paraaortic lymph node
             dissection in obese women. METHODS: We performed a
             retrospective analysis from 1/8/96 to 1/14/01 at the
             University of Oklahoma Health Science Center, evaluating
             patients who had a Quetelet index (QI) > or =28 and had
             planned laparoscopic bilateral pelvic and paraaortic lymph
             node dissections (lnd) for their gynecologic cancer. This
             group was compared to a matched group of patients that had
             lnd done by laparotomy. Patients were identified by our
             institution's database and data were collected by review of
             their medical records. Data were collected regarding
             demographics, stage, histology, length of stay, and
             procedural information including completion rates, estimated
             blood loss (EBL), operating room (OR) time, lymph node
             count, assistant, and complications. Associations between
             variables were analyzed using Student t tests and chi(2)
             testing, Excel v9.0. RESULTS: Fifty-five patients had
             planned laparoscopic lnd (Group 1) and 45 patients had lnd
             via laparotomy (Group 2). All patients had the diagnosis of
             endometrial cancer. The percentage of stage I patients did
             not differ between groups (42/55, 71.2% versus 37/45, 82.2%,
             P = n.s.). Age and QI were also similar between groups,
             (64.6 versus 58.4, 40.0 versus 39.3, P = n.s.). Laparoscopy
             was completed in 35/55 (63.6%) cases. Reasons for conversion
             included obesity (23.6%), adhesions (1.8%), intraperitoneal
             cancer (5.5%), and bleeding (5.5%). QI > or =35 was
             associated with a decreased success rate compared to QI <35
             (44.4% versus 82.1%, P = 0.004). There was no difference in
             successful laparoscopy when the first assistant was a fellow
             or a community obstetrician/gynecologist (61.0% versus
             50.0%, P = n.s.). The patients in Group 1 who had
             laparoscopy completed had a longer OR time compared to those
             in Group 2 (265.3 versus 140.7 min, P < 0.0001), EBL and
             transfusion rates were equivalent (361.8 versus 344.2 ml,
             5.6% versus 6.7%, P = n.s.), and length of stay was shorter
             (2.8 versus 4.5 days, P = 0.0004). Group 1 had significantly
             fewer postoperative fevers (5.5% versus 31.1%, P = 0.0007),
             fewer postoperative ileus (0% versus 13.3%, P = 0.005), and
             a trend for fewer wound infections (9.0% versus 22.2%, P =
             0.07). CONCLUSIONS: Obesity is not a contraindication to
             laparoscopic pelvic and paraaortic lymph node dissection.
             The overall success rate was significantly higher in those
             patients with a QI <35. Advantages include shorter hospital
             stay, fewer postoperative fevers, fewer postoperative ileus,
             and possibly fewer wound infections.},
   Language = {eng},
   Doi = {10.1006/gyno.2001.6548},
   Key = {fds174296}
}

@article{fds268929,
   Author = {Johnson, GA and Cofer, GP and Gewalt, SL and Hedlund,
             LW},
   Title = {Morphologic phenotyping with MR microscopy: the visible
             mouse.},
   Journal = {Radiology},
   Volume = {222},
   Number = {3},
   Pages = {789-793},
   Year = {2002},
   Month = {March},
   ISSN = {0033-8419},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/11867802},
   Keywords = {Animals • Contrast Media • Gadolinium DTPA •
             Imaging, Three-Dimensional* • Magnetic Resonance
             Imaging • Male • Mice • Mice, Inbred C57BL
             • Mice, Knockout • Microscopy • Phenotype
             • Urate Oxidase • administration & dosage •
             anatomy & histology* • diagnostic use • genetics
             • methods*},
   Abstract = {A method for rapid morphologic phenotyping is demonstrated
             by using magnetic resonance microscopy. Whole fixed C57BL/6J
             mice were imaged at 110-microm isotropic resolution; limited
             volumes of the intact specimen, at 50-microm isotropic
             resolution; and isolated organs, at 25-microm isotropic
             resolution. The three-dimensional imaging technique was
             applied to uricase knockout mice to demonstrate the method
             for the evaluation of morphologic phenotype.},
   Doi = {10.1148/radiol.2223010531},
   Key = {fds268929}
}

@booklet{Johnson02e,
   Author = {Johnson, GA and Hedlund, LW},
   Title = {Image based phenotyping: The visible mouse},
   Journal = {The FASEB journal : official publication of the Federation
             of American Societies for Experimental Biology},
   Volume = {16},
   Number = {5},
   Pages = {A1091-A1091},
   Year = {2002},
   Month = {March},
   ISSN = {0892-6638},
   url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000174593902021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
   Key = {Johnson02e}
}

@booklet{Johnson02f,
   Author = {G. A. Johnson and L. Pipas and N. B. Newman-palmer and L. H.
             Brown},
   Title = {The emergency medicine rotation: A unique experience for
             medical students},
   Journal = {Journal Of Emergency Medicine},
   Volume = {22},
   Number = {3},
   Pages = {307 -- 311},
   Year = {2002},
   Month = {April},
   Key = {Johnson02f}
}

@article{fds174191,
   Author = {GA Johnson and L Pipas and NB Newman-Palmer and LH
             Brown},
   Title = {The emergency medicine rotation: a unique experience for
             medical students.},
   Journal = {The Journal of emergency medicine},
   Volume = {22},
   Number = {3},
   Pages = {307-11},
   Year = {2002},
   Month = {April},
   ISSN = {0736-4679},
   Keywords = {Clinical Clerkship • Curriculum •
             Diagnosis-Related Groups • Emergency Medicine •
             Emergency Service, Hospital • Hospitals, Teaching
             • Humans • Internal Medicine • New York
             • Program Evaluation • Prospective Studies •
             education • education* • methods* •
             statistics & numerical data},
   Abstract = {The objective of this study was to determine if an Emergency
             Medicine (EM) rotation for medical students offers a unique
             educational opportunity, and to document those experiences.
             Thirty-three medical students at one teaching hospital
             recorded in a computer database information about their
             patient encounters during EM and Internal Medicine (IM)
             rotations. Data collected included the types of patients
             seen, the level of participation in patient care and
             decision making, and procedures performed. A total of 2740
             patient encounters were recorded, 1564 EM and 1176 IM.
             Students on EM rotations were more likely than students on
             IM rotations to be involved in the initial evaluation (93.1%
             vs. 47.0%, respectively), diagnosis (93.5% vs. 44.7%,
             respectively), and decision making (93.3% vs. 43.5%,
             respectively); they were also more likely to perform
             procedures (31.7% vs. 8.5%, respectively). There were
             significant differences in the patient populations and
             disease processes encountered on the two rotations as
             well.},
   Language = {eng},
   Key = {fds174191}
}

@booklet{Moller02,
   Author = {Möller, HE and Chen, XJ and Saam, B and Hagspiel, KD and Johnson, GA and Altes, TA and de Lange, EE and Kauczor, H-U},
   Title = {MRI of the lungs using hyperpolarized noble
             gases.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {47},
   Number = {6},
   Pages = {1029-1051},
   Year = {2002},
   Month = {June},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/12111949},
   Abstract = {The nuclear spin polarization of the noble gas isotopes
             (3)He and (129)Xe can be increased using optical pumping
             methods by four to five orders of magnitude. This
             extraordinary gain in polarization translates directly into
             a gain in signal strength for MRI. The new technology of
             hyperpolarized (HP) gas MRI holds enormous potential for
             enhancing sensitivity and contrast in pulmonary imaging.
             This review outlines the physics underlying the optical
             pumping process, imaging strategies coping with the
             nonequilibrium polarization, and effects of the alveolar
             microstructure on relaxation and diffusion of the noble
             gases. It presents recent progress in HP gas MRI and
             applications ranging from MR microscopy of airspaces to
             imaging pulmonary function in patients and suggests
             potential directions for future developments.},
   Doi = {10.1002/mrm.10173},
   Key = {Moller02}
}

@article{fds132808,
   Author = {HE Möller and XJ Chen and B Saam and KD Hagspiel and GA Johnson and TA
             Altes, EE de Lange and HU Kauczor},
   Title = {MRI of the lungs using hyperpolarized noble
             gases.},
   Journal = {Magnetic resonance in medicine : official journal of the
             Society of Magnetic Resonance in Medicine / Society of
             Magnetic Resonance in Medicine, United States},
   Volume = {47},
   Number = {6},
   Pages = {1029-51},
   Year = {2002},
   Month = {June},
   ISSN = {0740-3194},
   Keywords = {Animals • Forecasting • Helium • Humans
             • Lung • Lung Diseases • Magnetic Resonance
             Imaging • Noble Gases • Pulmonary Gas Exchange
             • Xenon Radioisotopes • anatomy & histology*
             • diagnosis* • diagnostic use • diagnostic
             use* • methods* • physiology*},
   Abstract = {The nuclear spin polarization of the noble gas isotopes
             (3)He and (129)Xe can be increased using optical pumping
             methods by four to five orders of magnitude. This
             extraordinary gain in polarization translates directly into
             a gain in signal strength for MRI. The new technology of
             hyperpolarized (HP) gas MRI holds enormous potential for
             enhancing sensitivity and contrast in pulmonary imaging.
             This review outlines the physics underlying the optical
             pumping process, imaging strategies coping with the
             nonequilibrium polarization, and effects of the alveolar
             microstructure on relaxation and diffusion of the noble
             gases. It presents recent progress in HP gas MRI and
             applications ranging from MR microscopy of airspaces to
             imaging pulmonary function in patients and suggests
             potential directions for future developments.},
   Key = {fds132808}
}

@booklet{Gareau02,
   Author = {Gareau, PJ and Wymore, AC and Cofer, GP and Johnson,
             GA},
   Title = {Imaging inflammation: direct visualization of perivascular
             cuffing in EAE by magnetic resonance microscopy.},
   Journal = {Journal of Magnetic Resonance Imaging},
   Volume = {16},
   Number = {1},
   Pages = {28-36},
   Year = {2002},
   Month = {July},
   ISSN = {1053-1807},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/12112500},
   Abstract = {PURPOSE: To determine if the architectural features revealed
             by magnetic resonance microscopy (MRM) allow one to detect
             microscopic abnormalities associated with neuroinflammation
             in fixed brain sections from animals with experimental
             allergic encephalomyelitis (EAE), an animal model for
             multiple sclerosis (MS). MATERIALS AND METHODS: Imaging was
             performed at the Center for In Vivo Microscopy (CIVM) using
             a 9.4-Tesla, 89-mm bore, superconducting magnet with
             actively shielded gradients capable of 850 mT/m. A number of
             MR contrasts and spatial resolutions were explored. RESULTS:
             The assessment of EAE brain showed that it is possible to
             visualize perivascular cuffing in vitro by MRM on
             three-dimensional T1 proton stains. CONCLUSION: Inflammatory
             cell infiltration is a prerequisite for the development of
             lesions in EAE and MS. Thus, the ability to directly detect
             individual perivascular cuffs of inflammation may provide a
             useful means of monitoring the time course of inflammatory
             events, as conventional histopathological scoring of
             perivascular cuffs is utilized, but in the absence of
             sectioning and staining.},
   Doi = {10.1002/jmri.10136},
   Key = {Gareau02}
}

@article{fds132842,
   Author = {PJ Gareau and AC Wymore and GP Cofer and GA Johnson},
   Title = {Imaging inflammation: direct visualization of perivascular
             cuffing in EAE by magnetic resonance microscopy.},
   Journal = {Journal of magnetic resonance imaging : JMRI, United
             States},
   Volume = {16},
   Number = {1},
   Pages = {28-36},
   Year = {2002},
   Month = {July},
   ISSN = {1053-1807},
   Keywords = {Animals • Brain • Disease Models, Animal •
             Encephalomyelitis, Autoimmune, Experimental • Female
             • Guinea Pigs • Inflammation • Magnetic
             Resonance Imaging • Microscopy • Multiple
             Sclerosis • methods* • pathology •
             pathology*},
   Abstract = {PURPOSE: To determine if the architectural features revealed
             by magnetic resonance microscopy (MRM) allow one to detect
             microscopic abnormalities associated with neuroinflammation
             in fixed brain sections from animals with experimental
             allergic encephalomyelitis (EAE), an animal model for
             multiple sclerosis (MS). MATERIALS AND METHODS: Imaging was
             performed at the Center for In Vivo Microscopy (CIVM) using
             a 9.4-Tesla, 89-mm bore, superconducting magnet with
             actively shielded gradients capable of 850 mT/m. A number of
             MR contrasts and spatial resolutions were explored. RESULTS:
             The assessment of EAE brain showed that it is possible to
             visualize perivascular cuffing in vitro by MRM on
             three-dimensional T1 proton stains. CONCLUSION: Inflammatory
             cell infiltration is a prerequisite for the development of
             lesions in EAE and MS. Thus, the ability to directly detect
             individual perivascular cuffs of inflammation may provide a
             useful means of monitoring the time course of inflammatory
             events, as conventional histopathological scoring of
             perivascular cuffs is utilized, but in the absence of
             sectioning and staining.},
   Key = {fds132842}
}

@booklet{Micheli02,
   Author = {F. Micheli and C. H. Peterson and L. S. Mullineaux and C. R.
             Fisher and S. W. Mills and G. Sancho and G. A. Johnson and H. S. Lenihan},
   Title = {Predation structures communities at deep-sea hydrothermal
             vents},
   Journal = {Ecological Monographs},
   Volume = {72},
   Number = {3},
   Pages = {365 -- 382},
   Year = {2002},
   Month = {August},
   Key = {Micheli02}
}

@booklet{Gray02,
   Author = {C. A. Gray and R. C. Burghardt and G. A. Johnson and F. W.
             Bazer and T. E. Spencer},
   Title = {Evidence that absence of endometrial gland secretions in
             uterine gland knockout ewes compromises conceptus survival
             and elongation},
   Journal = {Reproduction},
   Volume = {124},
   Number = {2},
   Pages = {289 -- 300},
   Year = {2002},
   Month = {August},
   Key = {Gray02}
}

@booklet{Johnson02c,
   Author = {G. A. Johnson and M. M. Joyce and S. J. Yankey and T. R.
             Hansen and T. L. Ott},
   Title = {The interferon stimulated genes (ISG) 17 and Mx have
             different temporal and spatial expression in the ovine
             uterus suggesting more complex regulation of the Mx
             gene},
   Journal = {Journal Of Endocrinology},
   Volume = {174},
   Number = {2},
   Year = {2002},
   Month = {August},
   Key = {Johnson02c}
}

@article{fds174138,
   Author = {CA Gray and RC Burghardt and GA Johnson and FW Bazer and TE
             Spencer},
   Title = {Evidence that absence of endometrial gland secretions in
             uterine gland knockout ewes compromises conceptus survival
             and elongation.},
   Journal = {Reproduction (Cambridge, England)},
   Volume = {124},
   Number = {2},
   Pages = {289-300},
   Year = {2002},
   Month = {August},
   ISSN = {1470-1626},
   Keywords = {Animals • Blastocyst • Blotting, Western •
             Embryonic and Fetal Development • Endometrium •
             Female • Integrins • Interferon Type I •
             Mucin-1 • Mucins • Osteopontin • Pregnancy
             • Pregnancy Proteins • Pregnancy, Animal •
             Progesterone • Sheep • Sialoglycoproteins •
             Uterus • analysis • anatomy & histology •
             blood • chemistry • metabolism* • physiology*
             • secretion*},
   Abstract = {Endometrial glands are necessary for conceptus implantation
             and growth. In the ovine uterine gland knockout (UGKO)
             model, blastocysts hatch normally but fail to survive or
             elongate. This peri-implantation defect in UGKO ewes may be
             due to the absence of endometrial glands or, alternatively,
             to the lack of certain epithelial adhesion molecules or the
             inability of the endometrium to respond to signals from the
             conceptus. Two studies were performed to examine these
             hypotheses. In study one, normal (n = 8) and UGKO (n = 12)
             ewes were mated at oestrus (day 0) with intact rams and
             their uteri were flushed 14 days after oestrus. Normal ewes
             (n = 4) were also flushed on 14 days after oestrus. Uterine
             flushes from bred normal ewes contained filamentous
             conceptuses (n = 7 of 8), whereas those from UGKO ewes
             contained no conceptus (n = 5 of 12), a growth-retarded,
             tubular conceptus (n = 6 of 12), or a fragmented,
             filamentous conceptus (n = 1 of 12). In all groups,
             expression of mucin 1 and integrin alpha(v), alpha(5),
             beta(3) and beta(5) was localized at the apical surface of
             the endometrial luminal epithelium with no detectable
             differences between normal and UGKO ewes. Uterine flushes
             from pregnant ewes, but not cyclic or UGKO ewes, contained
             abundant immunoreactive interferon tau and the cell adhesion
             proteins, osteopontin and glycosylation-dependent cell
             adhesion molecule one. In study two, UGKO ewes were fitted
             with uterine catheters 5 days after oestrus, infused with
             recombinant ovine interferon tau or control proteins from 11
             to 15 days after oestrus, and underwent hysterectomy 16 days
             after oestrus. Expression of several interferon
             tau-stimulated genes (ISG17, STAT1, STAT2 and IRF-1) was
             increased in the endometrium from interferon tau-infused
             UGKO ewes. These results support the hypothesis that the
             defects in conceptus elongation and survival in UGKO ewes
             are due to the absence of endometrial glands and their
             secretions rather than to alterations in expression of
             anti-adhesive or adhesive molecules on the endometrial
             luminal epithelium or to the responsiveness of the
             endometrium to the conceptus pregnancy recognition
             signal.},
   Language = {eng},
   Key = {fds174138}
}

@article{fds174163,
   Author = {GA Johnson and MM Joyce and SJ Yankey and TR Hansen and TL
             Ott},
   Title = {The Interferon Stimulated Genes (ISG) 17 and Mx have
             different temporal and spatial expression in the ovine
             uterus suggesting more complex regulation of the Mx
             gene.},
   Journal = {The Journal of endocrinology},
   Volume = {174},
   Number = {2},
   Pages = {R7-R11},
   Year = {2002},
   Month = {August},
   ISSN = {0022-0795},
   Keywords = {Animals • Estrous Cycle • Female •
             GTP-Binding Proteins* • Gene Expression Regulation
             • Gestational Age • Immunohistochemistry • In
             Situ Hybridization • Pregnancy • Pregnancy
             Proteins • Pregnancy, Animal • Proteins •
             RNA, Messenger • Random Allocation • Sheep •
             Uterus • analysis* • chemistry* • genetics*
             • metabolism* • methods},
   Abstract = {Interferon stimulated gene 17 (ISG17) and Mx are
             up-regulated in the ruminant uterus in response to
             interferon-tau (IFNtau) during early pregnancy. Recent
             evidence strongly indicates that expression of ISGs occur
             only in stroma (ST) and glandular epithelium (GE) during
             this time as a result of transcriptional repression by
             interferon regulatory factor two (IRF-2) expression in the
             LE. The present report tested this hypothesis by examining
             mRNA and protein expression of ISG17 and Mx in serial
             uterine cross-sections obtained from cyclic and early
             pregnant ewes. In situ and immunocytochemical analysis
             revealed that ISG17 mRNA and protein were low to
             undetectable, whereas Mx mRNA was expressed in the lumenal
             (LE) and superficial GE at all days of the estrous cycle
             examined. Both ISG17 and Mx mRNA increased in the stratum
             compactum ST between Days 11 and 13, and expression extended
             into the deep GE and stratum spongiosum ST on Days 15
             through 17 in pregnant ewes. Interestingly the Mx gene
             continued to be strongly expressed in LE and superficial GE
             through Day 17 of pregnancy, whereas ISG17 remained low to
             undetectable in these cells. Collectively, this study
             highlights the complexity of the uterine environment by
             unequivocally illustrating differential temporal and spatial
             expression of the IFN-responsive genes ISG17 and
             Mx.},
   Language = {eng},
   Key = {fds174163}
}

@article{fds132755,
   Author = {KJ Burg and M Delnomdedieu and RJ Beiler and CR Culberson and KG Greene and CR Halberstadt and WD Holder and AB Loebsack and WD Roland and GA
             Johnson},
   Title = {Application of magnetic resonance microscopy to tissue
             engineering: a polylactide model.},
   Journal = {Journal of biomedical materials research, United
             States},
   Volume = {61},
   Number = {3},
   Pages = {380-90},
   Year = {2002},
   Month = {September},
   ISSN = {0021-9304},
   Keywords = {Absorbable Implants • Animals • Aorta •
             Biocompatible Materials • Cell Survival • Magnetic
             Resonance Imaging* • Materials Testing •
             Microscopy • Muscle, Smooth, Vascular • Polyesters
             • Porosity • Rats • Tissue Engineering •
             cytology • instrumentation • instrumentation*
             • methods • methods*},
   Abstract = {Absorbable polymers are unique materials that find
             application as temporary scaffolds in tissue engineering.
             They are often extremely sensitive to histological
             processing and, for this reason, studying fragile,
             tissue-engineered constructs before implantation can be
             quite difficult. This research investigates the use of
             noninvasive imaging using magnetic resonance microscopy
             (MRM) as a tool to enhance the assessment of these cellular
             constructs. A series of cellular, polylactide constructs was
             developed and analyzed using a battery of tests, including
             MRM. Distribution of rat aortic smooth muscle cells within
             the scaffolds was compared as one example of a tissue
             engineering MRM application. Cells were loaded in varying
             amounts using static and dynamic methods. It was found that
             the cellular component was readily identified and the
             polymer microstructure readily assessed. Specifically, the
             MRM results showed a heterogeneous distribution of cells due
             to static loading and a homogenous distribution associated
             with dynamic loading, results that were not visible through
             biochemical tests, scanning electron microscopy, or
             histological evaluation independently. MRM also allowed
             differentiation between different levels of cellular
             loading. The current state of MRM is such that it is
             extremely useful in the refinement of polymer processing and
             cell seeding methods. This method has the potential, with
             technological advances, to be of future use in the
             characterization of cell-polymer interactions.},
   Key = {fds132755}
}

@booklet{Burg02,
   Author = {Burg, KJL and Delnomdedieu, M and Beiler, RJ and Culberson, CR and Greene, KG and Halberstadt, CR and Holder, WD and Loebsack, AB and Roland, WD and Johnson, GA},
   Title = {Application of magnetic resonance microscopy to tissue
             engineering: a polylactide model.},
   Journal = {Journal of Biomedical Materials Research},
   Volume = {61},
   Number = {3},
   Pages = {380-390},
   Year = {2002},
   Month = {September},
   ISSN = {0021-9304},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/12115463},
   Abstract = {Absorbable polymers are unique materials that find
             application as temporary scaffolds in tissue engineering.
             They are often extremely sensitive to histological
             processing and, for this reason, studying fragile,
             tissue-engineered constructs before implantation can be
             quite difficult. This research investigates the use of
             noninvasive imaging using magnetic resonance microscopy
             (MRM) as a tool to enhance the assessment of these cellular
             constructs. A series of cellular, polylactide constructs was
             developed and analyzed using a battery of tests, including
             MRM. Distribution of rat aortic smooth muscle cells within
             the scaffolds was compared as one example of a tissue
             engineering MRM application. Cells were loaded in varying
             amounts using static and dynamic methods. It was found that
             the cellular component was readily identified and the
             polymer microstructure readily assessed. Specifically, the
             MRM results showed a heterogeneous distribution of cells due
             to static loading and a homogenous distribution associated
             with dynamic loading, results that were not visible through
             biochemical tests, scanning electron microscopy, or
             histological evaluation independently. MRM also allowed
             differentiation between different levels of cellular
             loading. The current state of MRM is such that it is
             extremely useful in the refinement of polymer processing and
             cell seeding methods. This method has the potential, with
             technological advances, to be of future use in the
             characterization of cell-polymer interactions.},
   Doi = {10.1002/jbm.10146},
   Key = {Burg02}
}

@booklet{Johnson02a,
   Author = {Johnson, GA and Cofer, GP and Fubara, B and Gewalt, SL and Hedlund, LW and Maronpot, RR},
   Title = {Magnetic resonance histology for morphologic
             phenotyping.},
   Journal = {Journal of Magnetic Resonance Imaging},
   Volume = {16},
   Number = {4},
   Pages = {423-429},
   Year = {2002},
   Month = {October},
   ISSN = {1053-1807},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/12353257},
   Abstract = {Magnetic resonance histology (MRH) images of the whole mouse
             have been acquired at 100-micron isotropic resolution at 2.0
             T with image arrays of 256 x 256 x 1024. Higher resolution
             (50 x 50 x 50 microns) of limited volumes has been acquired
             at 7.1T with image arrays of 512 x 512 x 512. Even higher
             resolution images (20 x 20 x 20 microns) of isolated organs
             have been acquired at 9.4 T. The volume resolution
             represents an increase of 625000 x over conventional
             clinical MRI. The technological basis is summarized that
             will allow basic scientists to begin using MRH as a routine
             method for morphologcic phenotyping of the mouse. MRH
             promises four unique attributes over conventional histology:
             1). MRH is non-destructive; 2). MRH exploits the unique
             contrast mechanisms that have made MRI so successful
             clinically; 3). MRH is 3-dimensional; and 4). the data are
             inherently digital. We demonstrate the utility in
             morphologic phenotyping a whole C57BL/6J
             mouse.},
   Doi = {10.1002/jmri.10175},
   Key = {Johnson02a}
}

@article{fds132780,
   Author = {GA Johnson and GP Cofer and B Fubara and SL Gewalt and LW Hedlund and RR
             Maronpot},
   Title = {Magnetic resonance histology for morphologic
             phenotyping.},
   Journal = {Journal of magnetic resonance imaging : JMRI, United
             States},
   Volume = {16},
   Number = {4},
   Pages = {423-9},
   Year = {2002},
   Month = {October},
   ISSN = {1053-1807},
   Keywords = {Animals • Magnetic Resonance Imaging* • Mice
             • Mice, Inbred C57BL • Phenotype •
             methods},
   Abstract = {Magnetic resonance histology (MRH) images of the whole mouse
             have been acquired at 100-micron isotropic resolution at 2.0
             T with image arrays of 256 x 256 x 1024. Higher resolution
             (50 x 50 x 50 microns) of limited volumes has been acquired
             at 7.1T with image arrays of 512 x 512 x 512. Even higher
             resolution images (20 x 20 x 20 microns) of isolated organs
             have been acquired at 9.4 T. The volume resolution
             represents an increase of 625000 x over conventional
             clinical MRI. The technological basis is summarized that
             will allow basic scientists to begin using MRH as a routine
             method for morphologcic phenotyping of the mouse. MRH
             promises four unique attributes over conventional histology:
             1). MRH is non-destructive; 2). MRH exploits the unique
             contrast mechanisms that have made MRI so successful
             clinically; 3). MRH is 3-dimensional; and 4). the data are
             inherently digital. We demonstrate the utility in
             morphologic phenotyping a whole C57BL/6J
             mouse.},
   Key = {fds132780}
}

@booklet{Orlander02,
   Author = {J. D. Orlander and B. G. Fincke and D. Hermanns and G. A.
             Johnson},
   Title = {Medical residents' first clearly remembered experiences of
             giving bad news},
   Journal = {Journal Of General Internal Medicine},
   Volume = {17},
   Number = {11},
   Pages = {825 -- 840},
   Year = {2002},
   Month = {November},
   Key = {Orlander02}
}

@article{fds174101,
   Author = {JD Orlander and BG Fincke and D Hermanns and GA Johnson},
   Title = {Medical residents' first clearly remembered experiences of
             giving bad news.},
   Journal = {Journal of general internal medicine},
   Volume = {17},
   Number = {11},
   Pages = {825-31},
   Year = {2002},
   Month = {November},
   ISSN = {0884-8734},
   Keywords = {Adult • Communication • Female • Health
             Surveys • Humans • Internal Medicine* •
             Internship and Residency* • Male •
             Physician-Patient Relations*},
   Abstract = {CONTEXT: Communication of bad news to patients or families
             is a difficult task that requires skill and sensitivity.
             Little is known about doctors' formative experiences in
             giving bad news, what guidance they receive, or what lessons
             they learn in the process. OBJECTIVE: To learn the
             circumstances in which medical residents first delivered bad
             news to patients or families, the nature of their
             experience, and their opinions about how best to develop the
             needed skills. DESIGN: Confidential mailed survey. SETTING
             AND SUBJECTS: All medicine house officers at 2 urban,
             university-based residency programs in Boston. MAIN OUTCOME
             MEASURES: Details of medical residents' first clearly
             remembered experiences of giving bad news to a patient or
             family member; year in training; familiarity with the
             patient; information about any planning prior to,
             observation of, or discussion after their first experience;
             and the usefulness of such discussions. We also asked
             general questions about delivering bad news, such as how
             often this was done, as well as asking for opinions about
             actual and desired training. RESULTS: One hundred
             twenty-nine of two hundred thirteen surveys (61%) were
             returned. Most (73%) trainees first delivered bad news while
             a medical student or intern. For this first experience, most
             (61%) knew the patient for just hours or days. Only 59%
             engaged in any planning for the encounter. An attending
             physician was present in 6 (5%) instances, and a more-senior
             trainee in 14 (11%) others. Sixty-five percent of subjects
             debriefed with at least 1 other person after the encounter,
             frequently with a lesser-trained physician or a member of
             their own family. Debriefing focused on the reaction of
             those who were given the bad news and the reaction of the
             trainee. When there were discussions with more-senior
             physicians, before or after the encounter, these were judged
             to be helpful approximately 80% of the time. Most subjects
             had given bad news between 5 and 20 times, yet 10% had never
             been observed doing so. Only 81 of 128 (63%) had ever
             observed an attending delivering bad news, but those who did
             found it helpful 96% of the time. On 7-point scales,
             subjects rated the importance of skills in delivering bad
             news highly, (mean 6.8), believed such skill can be improved
             (mean 6.6), and thought that more guidance should be offered
             to them during such activity (mean 5.8). CONCLUSION: Medical
             students and residents frequently deliver bad news to
             patients and families. This responsibility begins early in
             training. In spite of their inexperience, many do not appear
             to receive adequate guidance or support during their
             earliest formative experiences.},
   Language = {eng},
   Key = {fds174101}
}

@booklet{Johnson02,
   Author = {G. A. Johnson and T. A. Day},
   Title = {Enhancement of photosynthesis in Sorghum bicolor by
             ultraviolet radiation},
   Journal = {Physiologia Plantarum},
   Volume = {116},
   Number = {4},
   Pages = {554 -- 562},
   Year = {2002},
   Month = {December},
   Key = {Johnson02}
}

@booklet{Wu03,
   Author = {G. Y. Wu and J. T. Self and G. A. Johnson and F. W. Bazer and T. E. Spencer},
   Title = {Developmental changes in placental nitric oxide synthesis in
             pigs},
   Journal = {Biology Of Reproduction},
   Volume = {68},
   Pages = {153 -- 153},
   Year = {2003},
   Key = {Wu03}
}

@booklet{Johnson03a,
   Author = {G. A. Johnson and M. M. Joyce and S. Lewis and J. F.
             Gonzalez and R. C. Burghardt and S. Woldesenbet and G. R.
             Newton},
   Title = {Caprine uterine and placental osteopontin (OPN) expression
             is distinct among epitheliochorial implanting
             species.},
   Journal = {Biology Of Reproduction},
   Volume = {68},
   Pages = {205 -- 206},
   Year = {2003},
   Key = {Johnson03a}
}

@booklet{Kodali03,
   Author = {K. Kodali and C. M. Davitt and G. A. Johnson and T. L.
             Ott},
   Title = {Dynamin family member and antiviral protein, Mx,
             co-localizes with autocrine motility factor receptor in an
             ovine uterine lumenal epithelial cell line.},
   Journal = {Biology Of Reproduction},
   Volume = {68},
   Pages = {181 -- 181},
   Year = {2003},
   Key = {Kodali03}
}

@booklet{Spencer03,
   Author = {T. E. Spencer and R. C. Burghardt and G. A. Johnson and F.
             W. Bazer},
   Title = {Biology of progesterone and placental hormone actions on the
             uterus.},
   Journal = {Biology Of Reproduction},
   Volume = {68},
   Pages = {96 -- 97},
   Year = {2003},
   Key = {Spencer03}
}

@booklet{Spencer03a,
   Author = {T. E. Spencer and G. A. Johnson and F. W. Bazer and G. Y.
             Wu},
   Title = {Regulation of placental nitric oxide synthesis by estrogen
             and progesterone in pigs.},
   Journal = {Biology Of Reproduction},
   Volume = {68},
   Pages = {363 -- 364},
   Year = {2003},
   Key = {Spencer03a}
}

@booklet{Joyce03,
   Author = {M. M. Joyce and R. C. Burghardt and F. W. Bazer and G. M.
             Zaunbrecher and G. A. Johnson},
   Title = {Interferon-stimulated genes (ISGs) are induced in the
             endometrium of pregnant but not pseudopregnant
             pigs.},
   Journal = {Biology Of Reproduction},
   Volume = {68},
   Pages = {206 -- 206},
   Year = {2003},
   Key = {Joyce03}
}

@booklet{Zaunbrecher03,
   Author = {G. M. Zaunbrecher and T. E. Spencer and R. C. Burghardt and M. M. Joyce and F. W. Bazer and G. A. Johnson},
   Title = {Regulaton of glycosylation dependent cell adhesion molecule
             1 (GlyCAM-1) and l-selectin expression in the pregnant ovine
             uterus and placenta.},
   Journal = {Biology Of Reproduction},
   Volume = {68},
   Pages = {243 -- 243},
   Year = {2003},
   Key = {Zaunbrecher03}
}

@booklet{Fichter03,
   Author = {C. R. Fichter and G. A. Johnson and S. R. Braddock and J. D.
             Tobias},
   Title = {Perioperative care of the child with the Johanson-Blizzard
             syndrome},
   Journal = {Paediatric Anaesthesia},
   Volume = {13},
   Number = {1},
   Pages = {72 -- 75},
   Year = {2003},
   Month = {January},
   Key = {Fichter03}
}

@booklet{Chen03,
   Author = {Chen, BT and Brau, ACS and Johnson, GA},
   Title = {Measurement of regional lung function in rats using
             hyperpolarized 3helium dynamic MRI.},
   Journal = {Magnetic Resonance in Medicine},
   Volume = {49},
   Number = {1},
   Pages = {78-88},
   Year = {2003},
   Month = {January},
   ISSN = {0740-3194},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/12509822},
   Abstract = {Dynamic regional lung function was investigated in rats
             using a radial acquisition cine (RA-CINE) pulse sequence
             together with hyperpolarized (HP) (3)He gas delivered by a
             constant flow ventilator. Based on regional differences in
             the behavior of inspired air, the lung was conceptually
             divided into two regions (the major airways and the
             peripheral airspace) for purposes of functional analysis. To
             measure regional function in the major airways, a large RF
             flip angle (24 degrees) was applied to reduce (3)He
             magnetization in the peripheral airspace, and signal
             intensity (SI) was normalized with the projected airway
             diameter to estimate local airflow. Higher normalized signal
             intensity was observed in the left branch airway as compared
             to the right branch airway. To determine regional function
             in the peripheral airspace, a small RF flip angle (6
             degrees) was used. Incremental increases of peripheral SI in
             successive lung images were consistent with the increase in
             lung volume. A new "skipping" scanning strategy using dummy
             frames allows a trade-off between the number of frames
             acquired for dynamic information, the RF flip angle, and the
             penetration depth of (3)He magnetization into the lung. This
             work provides a novel approach to simultaneously assess
             dynamic regional function and morphology.},
   Doi = {10.1002/mrm.10336},
   Key = {Chen03}
}

@article{fds174068,
   Author = {CR Fichter and GA Johnson, SR Braddock and JD Tobias},
   Title = {Perioperative care of the child with the Johanson-Blizzard
             syndrome.},
   Journal = {Paediatric anaesthesia},
   Volume = {13},
   Number = {1},
   Pages = {72-5},
   Year = {2003},
   Month = {January},
   ISSN = {1155-5645},
   Keywords = {Abnormalities, Multiple • Anesthesia, Inhalation*
             • Anesthetics, Inhalation • Child, Preschool
             • Dwarfism • Female • Genes, Recessive •
             Humans • Methyl Ethers • Nose • Syndrome
             • abnormalities • complications •
             surgery*},
   Abstract = {The Johanson-Blizzard Syndrome (JBS) is an autosomal
             recessive disorder with a characteristic phenotype,
             including dwarfism, a beaked nose with aplastic alae nasi, a
             high forehead, mid-line ectodermal scalp defects with sparse
             hair and absent eyelashes/eyebrows, prominent scalp veins,
             low set ears, a large anterior fontanelle, micrognathia,
             thin lips, absent permanent dentition and microcephaly. In
             addition to the characteristic facial features, associated
             conditions include congenital heart disease,
             exocrine/endocrine pancreatic dysfunction, hypothyroidism,
             hypopituitarism, mental retardation, sensorineural hearing
             loss and vesico-ureteral reflux. A case is presented and the
             potential anaesthetic implications of this syndrome are
             discussed.},
   Language = {eng},
   Key = {fds174068}
}

@article{fds132882,
   Author = {BT Chen and AC Brau and GA Johnson},
   Title = {Measurement of regional lung function in rats using
             hyperpolarized 3helium dynamic MRI.},
   Journal = {Magnetic resonance in medicine : official journal of the
             Society of Magnetic Resonance in Medicine / Society of
             Magnetic Resonance in Medicine, United States},
   Volume = {49},
   Number = {1},
   Pages = {78-88},
   Year = {2003},
   Month = {January},
   ISSN = {0740-3194},
   Keywords = {Animals • Female • Helium • Image Processing,
             Computer-Assisted • Isotopes • Lung •
             Magnetic Resonance Imaging, Cine* • Phantoms, Imaging
             • Rats • Rats, Sprague-Dawley • Respiratory
             Mechanics* • Tidal Volume • anatomy & histology
             • diagnostic use • physiology*},
   Abstract = {Dynamic regional lung function was investigated in rats
             using a radial acquisition cine (RA-CINE) pulse sequence
             together with hyperpolarized (HP) (3)He gas delivered by a
             constant flow ventilator. Based on regional differences in
             the behavior of inspired air, the lung was conceptually
             divided into two regions (the major airways and the
             peripheral airspace) for purposes of functional analysis. To
             measure regional function in the major airways, a large RF
             flip angle (24 degrees) was applied to reduce (3)He
             magnetization in the peripheral airspace, and signal
             intensity (SI) was normalized with the projected airway
             diameter to estimate local airflow. Higher normalized signal
             intensity was observed in the left branch airway as compared
             to the right branch airway. To determine regional function
             in the peripheral airspace, a small RF flip angle (6
             degrees) was used. Incremental increases of peripheral SI in
             successive lung images were consistent with the increase in
             lung volume. A new "skipping" scanning strategy using dummy
             frames allows a trade-off between the number of frames
             acquired for dynamic information, the RF flip angle, and the
             penetration depth of (3)He magnetization into the lung. This
             work provides a novel approach to simultaneously assess
             dynamic regional function and morphology.},
   Key = {fds132882}
}

@booklet{Gray03,
   Author = {C. A. Gray and M. D. Stewart and G. A. Johnson and T. E.
             Spencer},
   Title = {Postpartum uterine involution in sheep: histoarchitecture
             and changes in endometrial gene expression},
   Journal = {Reproduction},
   Volume = {125},
   Number = {2},
   Pages = {185 -- 198},
   Year = {2003},
   Month = {February},
   Key = {Gray03}
}

@article{fds174285,
   Author = {CA Gray, MD Stewart and GA Johnson and TE Spencer},
   Title = {Postpartum uterine involution in sheep: histoarchitecture
             and changes in endometrial gene expression.},
   Journal = {Reproduction (Cambridge, England)},
   Volume = {125},
   Number = {2},
   Pages = {185-98},
   Year = {2003},
   Month = {February},
   ISSN = {1470-1626},
   Keywords = {Animals • Apoptosis • B-Lymphocytes •
             Epithelium • Estradiol • Estrogen Receptor alpha
             • Female • Glycoproteins • Hysterectomy
             • Immunohistochemistry • In Situ Hybridization
             • Organ Size • Ovariectomy • Placenta •
             Postpartum Period • Pregnancy • Progesterone
             • RNA, Messenger • Receptors, Estrogen •
             Receptors, Oxytocin • Receptors, Progesterone •
             Receptors, Prolactin • Serpins* • Sheep •
             T-Lymphocytes • Uterus • analysis • anatomy &
             histology • anatomy & histology* • blood •
             cytology • genetics • immunology • metabolism
             • physiology*},
   Abstract = {After parturition, the uterus undergoes marked remodelling
             during involution; however, little is known of the hormonal,
             cellular and molecular mechanisms that regulate this
             process. The working hypothesis used in this study is that
             return of the ovine uterus to a non-pregnant state involves
             termination of a hormonal servomechanism that regulates
             endometrial gland morphogenesis and function during
             pregnancy. Suffolk ewes were ovariohysterectomized on
             postpartum days 1, 7, 14 or 28. Serum concentrations of
             oestradiol were high at parturition, declined to postpartum
             day 4, peaked on postpartum day 6, and then declined and
             remained low thereafter. Progesterone was undetectable in
             plasma from ewes post partum. Uterine wet mass and horn
             length decreased after postpartum day 1, but ovarian mass
             did not change. Residual placental cotyledons were present
             in the maternal caruncles on postpartum days 1 and 7 and
             were extruded by postpartum day 14 as plaques that were
             resorbed by postpartum day 28. The width of the total
             endometrium, stratum compactum, stratum spongiosum and
             myometrium, as well as endometrial gland density, decreased
             after parturition. Most apoptotic cells in the involuting
             uterus were large, vacuolated and located between the
             endometrial glandular epithelial cells on postpartum days 1
             and 7. Immunofluorescence analyses identified both T and B
             cells within the glandular epithelium on postpartum day 1.
             Cell proliferation was detected in the luminal epithelium
             and glandular epithelium on postpartum days 1 and 7. On
             postpartum day 1, expression of oestrogen receptor alpha
             (ERalpha) was not detected in luminal epithelium and was low
             in glandular epithelium, but ERalpha was present in
             epithelia thereafter. Progesterone receptor (PR) protein was
             not detected in endometrial epithelia on postpartum day 1,
             but was detected in the glandular epithelium thereafter.
             Between postpartum days 1 and 7, ERalpha and PR protein
             increased substantially in the endometrial glandular
             epithelium. On postpartum days 1-28, abundant expression of
             oxytocin receptor mRNA was detected in endometrial luminal
             epithelium and superficial to the middle glandular
             epithelium. Prolactin receptor (PRLR) mRNA was detected in
             glandular epithelium on all postpartum days, whereas mRNA
             for uterine milk protein (UTMP), an index of secretory
             capacity of glandular epithelium, was present only on
             postpartum day 1. Collectively, these results indicate that
             uterine involution in ewes involves remodelling of both
             caruncular and intercaruncular areas of the uterine wall and
             termination of differentiated uterine gland functions
             characteristic of pregnancy.},
   Language = {eng},
   Key = {fds174285}
}

@booklet{Noel03,
   Author = {S. Noel and A. Herman and G. A. Johnson and C. A. Gray and M. D. Stewart and F. W. Bazer and A. Gertler and T. E.
             Spencer},
   Title = {Ovine placental lactogen specifically rinds to endometrial
             glands of the ovine uterus},
   Journal = {Biology Of Reproduction},
   Volume = {68},
   Number = {3},
   Pages = {772 -- 780},
   Year = {2003},
   Month = {March},
   Key = {Noel03}
}

@booklet{Kim03,
   Author = {J. G. Kim and J. H. Song and J. L. Vallet and G. A. Rohrer and G. A. Johnson and M. M. Joyce and R. K.
             Christenson},
   Title = {Molecular characterization and expression of porcine bone
             morphogenetic protein receptor-IB in the uterus of cyclic
             and pregnant gilts},
   Journal = {Biology Of Reproduction},
   Volume = {68},
   Number = {3},
   Pages = {735 -- 743},
   Year = {2003},
   Month = {March},
   Key = {Kim03}
}

@article{fds174173,
   Author = {JG Kim and JH Song and JL Vallet and GA Rohrer and GA Johnson and MM Joyce and RK Christenson},
   Title = {Molecular characterization and expression of porcine bone
             morphogenetic protein receptor-IB in the uterus of cyclic
             and pregnant gilts.},
   Journal = {Biology of reproduction},
   Volume = {68},
   Number = {3},
   Pages = {735-43},
   Year = {2003},
   Month = {March},
   ISSN = {0006-3363},
   Keywords = {Amino Acid Sequence • Animals • Base Sequence
             • Blotting, Northern • Bone Morphogenetic Protein
             Receptors, Type I • Chromosome Mapping • Cloning,
             Molecular • Crosses, Genetic • DNA, Complementary
             • Endometrium • Expressed Sequence Tags •
             Female • Gene Expression Regulation • In Situ
             Hybridization • Male • Molecular Sequence Data
             • Point Mutation • Pregnancy • Pregnancy,
             Animal • Protein-Serine-Threonine Kinases • RNA,
             Messenger • Receptors, Growth Factor • Sequence
             Alignment • Sequence Analysis, DNA • Swine •
             biosynthesis • chemistry • genetics •
             genetics* • isolation & purification • metabolism
             • metabolism* • physiology •
             veterinary},
   Abstract = {Previous gene mapping analyses revealed a quantitative trait
             locus for uterine capacity on chromosome 8. Comparison of
             porcine and human genetic maps suggests that the bone
             morphogenetic protein receptor IB (BMPR-IB) gene may be
             located near this region. The objectives of this study were
             to 1) clone the full coding region for BMPR-IB, 2) examine
             BMPR-IB gene expression by the endometrium and its cellular
             localization in cyclic and pregnant gilts, and 3) map the
             BMPR-IB gene. By iterative screening of an expressed
             sequence tag library, we obtained a 3559-base pair cDNA
             clone including the full coding region of BMPR-IB.
             Endometrial BMPR-IB mRNA expression of White composite gilts
             was determined by Northern blotting in Days 10, 13, and 15
             cyclic and Days 10, 13, 15, 20, 30, and 40 pregnant gilts.
             In cyclic gilts, endometrial BMPR-IB mRNA expression was
             elevated on Days 13 and 15 (P < 0.01) compared with Day 10.
             Expression of BMPR-IB mRNA was localized in both luminal and
             glandular epithelium on Day 15. However, in pregnant gilts,
             BMPR-IB mRNA expression was not significantly different in
             the endometrium from Day 10 to Day 20, and it was
             significantly decreased on Days 30 and 40 (P = 0.011). The
             BMPR-IB gene was mapped to 108 cM on chromosome 8. These
             findings show that BMPR-IB mRNA expression is regulated
             differently in cyclic and pregnant gilts; this pattern of
             gene expression may be important for endometrial function
             during the luteal phase of the estrous cycle as compared
             with early pregnancy.},
   Language = {eng},
   Key = {fds174173}
}

@article{fds174188,
   Author = {S Noel and A Herman and GA Johnson and CA Gray, MD Stewart and FW Bazer and A Gertler and TE Spencer},
   Title = {Ovine placental lactogen specifically binds to endometrial
             glands of the ovine uterus.},
   Journal = {Biology of reproduction},
   Volume = {68},
   Number = {3},
   Pages = {772-80},
   Year = {2003},
   Month = {March},
   ISSN = {0006-3363},
   Keywords = {Animals • Binding Sites • Binding, Competitive
             • Blotting, Western • Endometrium • Female
             • Growth Hormone • Interferon Type I • Male
             • Placental Hormones • Placental Lactogen •
             Pregnancy Proteins • Prolactin • RNA • Random
             Allocation • Receptors, Prolactin • Receptors,
             Somatotropin • Reverse Transcriptase Polymerase Chain
             Reaction • Sheep • chemistry • genetics
             • metabolism • metabolism* • pharmacology
             • physiology • ultrastructure •
             veterinary},
   Abstract = {A hormonal servomechanism has been proposed to regulate
             differentiation and function of the endometrial glandular
             epithelium (GE) in the ovine uterus during pregnancy. This
             mechanism involves sequential actions of estrogen,
             progesterone, ovine interferon tau (IFNtau), placental
             lactogen (oPL), and placental growth hormone (oGH). The
             biological actions of oPL in vitro are mediated by
             homodimerization of the prolactin receptor (oPRLR) and
             heterodimerization of the oPRLR and oGH receptor. The
             objectives of the study were to determine the effects of
             intrauterine oPL, oGH, and their combination on endometrial
             histoarchitecture and gene expression and to localize and
             characterize binding sites for oPL in the ovine uterus in
             vivo using an in situ ligand binding assay. Intrauterine
             infusion of oPL and/or oGH following IFNtau into
             ovariectomized ewes treated with progesterone daily
             differentially affected endometrial gland number and
             expression of uterine milk proteins and osteopontin.
             However, neither hormone affected PRLR, insulin-like growth
             factor (IGF)-I, or IGF-II mRNA levels in the endometrium. A
             chimeric protein of placental secretory alkaline phosphatase
             (SEAP) and oPL was used to identify and characterize binding
             sites for oPL in frozen sections of interplacentomal
             endometrium from pregnant ewes. Specific binding of SEAP-oPL
             was detected in the endometrial GE on Days 30, 60, 90, and
             120 of pregnancy. In Day 90 endometrium, SEAP-oPL binding to
             the endometrial GE was displaced completely by oPL and
             prolactin (oPRL) but only partially by oGH. Binding
             experiments using the extracellular domain of the oPRLR also
             showed that iodinated oPL binding sites could be competed
             for by oPRL and oPL but not by oGH. Collectively, results
             indicate that oPL binds to receptors in the endometrial
             glands and that oPRL is more effective than oGH in competing
             for these binding sites. Thus, effects of oPL on the
             endometrial glands may be mediated by receptors for oPRL and
             oGH.},
   Language = {eng},
   Key = {fds174188}
}

@booklet{Choi03,
   Author = {Y. Choi and G. A. Johnson and T. E. Spencer and F. W.
             Bazer},
   Title = {Pregnancy and interferon tau regulate major
             histocompatibility complex class I and beta(2)-microglobulin
             expression in the ovine uterus},
   Journal = {Biology Of Reproduction},
   Volume = {68},
   Number = {5},
   Pages = {1703 -- 1710},
   Year = {2003},
   Month = {May},
   Key = {Choi03}
}

@article{fds174102,
   Author = {Y Choi and GA Johnson and TE Spencer and FW Bazer},
   Title = {Pregnancy and interferon tau regulate major
             histocompatibility complex class I and beta2-microglobulin
             expression in the ovine uterus.},
   Journal = {Biology of reproduction},
   Volume = {68},
   Number = {5},
   Pages = {1703-10},
   Year = {2003},
   Month = {May},
   ISSN = {0006-3363},
   url = {http://dx.doi.org/10.1095/biolreprod.102.012708},
   Keywords = {Animals • Endometrium • Estrous Cycle •
             Female • Fluorescent Antibody Technique • Gene
             Expression Regulation, Developmental • Genes, MHC Class
             I • In Situ Hybridization • Interferon Type I
             • Pregnancy • Pregnancy Proteins • Pregnancy,
             Animal • RNA, Messenger • Sheep • Uterus
             • bet