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Publications of Elaine E. Guevara    :recent first  alphabetical  combined listing:

%% Journal Articles   
@article{fds346153,
   Author = {Guevara, EE and Steiper, ME},
   Title = {Molecular phylogenetic analysis of the Papionina using
             concatenation and species tree methods.},
   Journal = {Journal of Human Evolution},
   Volume = {66},
   Pages = {18-28},
   Year = {2014},
   Month = {January},
   url = {http://dx.doi.org/10.1016/j.jhevol.2013.09.003},
   Abstract = {The Papionina is a geographically widespread subtribe of
             African cercopithecid monkeys whose evolutionary history is
             of particular interest to anthropologists. The phylogenetic
             relationships among arboreal mangabeys (Lophocebus), baboons
             (Papio), and geladas (Theropithecus) remain unresolved.
             Molecular phylogenetic analyses have revealed marked gene
             tree incongruence for these taxa, and several recent
             concatenated phylogenetic analyses of multilocus datasets
             have supported different phylogenetic hypotheses. To address
             this issue, we investigated the phylogeny of the
             Lophocebus + Papio + Theropithecus group using
             concatenation methods, as well as alternative methods that
             incorporate gene tree heterogeneity to estimate a 'species
             tree.' Our compiled DNA sequence dataset was ∼56 kb pairs
             long and included 57 independent partitions. All analyses of
             concatenated alignments strongly supported a
             Lophocebus + Papio clade and a basal position for
             Theropithecus. The Bayesian concordance analysis supported
             the same phylogeny. A coalescent-based Bayesian method
             resulted in a very poorly resolved species tree. The
             topological agreement between concatenation and the Bayesian
             concordance analysis offers considerable support for a
             Lophocebus + Papio clade as the dominant relationship
             across the genome. However, the results of the Bayesian
             concordance analysis indicate that almost half the genome
             has an alternative history. As such, our results offer a
             well-supported phylogenetic hypothesis for the
             Papio/Lophocebus/Theropithecus trichotomy, while at the same
             time providing evidence for a complex evolutionary history
             that likely includes hybridization among
             lineages.},
   Doi = {10.1016/j.jhevol.2013.09.003},
   Key = {fds346153}
}

@article{fds346152,
   Author = {Perlman, RF and de Vries, D and Jacobs, RL and Holowka, NB and Pain, EL and Guevara, EE and Thompson, NE},
   Title = {The gateway to anthropology in St. Louis.},
   Journal = {Evolutionary Anthropology},
   Volume = {24},
   Number = {3},
   Pages = {101-103},
   Year = {2015},
   Month = {May},
   url = {http://dx.doi.org/10.1002/evan.21450},
   Doi = {10.1002/evan.21450},
   Key = {fds346152}
}

@article{fds346151,
   Author = {Perlman, RF and Nishimura, AC and Mongle, CS and Kling, K and Guevara,
             EE and Arslanian, K},
   Title = {Life's a peach for anthropologists in atlanta.},
   Journal = {Evolutionary Anthropology},
   Volume = {25},
   Number = {3},
   Pages = {81-83},
   Year = {2016},
   Month = {May},
   url = {http://dx.doi.org/10.1002/evan.21493},
   Doi = {10.1002/evan.21493},
   Key = {fds346151}
}

@article{fds346150,
   Author = {Guevara, EE and Veilleux, CC and Saltonstall, K and Caccone, A and Mundy, NI and Bradley, BJ},
   Title = {Potential arms race in the coevolution of primates and
             angiosperms: brazzein sweet proteins and gorilla taste
             receptors.},
   Journal = {American Journal of Physical Anthropology},
   Volume = {161},
   Number = {1},
   Pages = {181-185},
   Year = {2016},
   Month = {September},
   url = {http://dx.doi.org/10.1002/ajpa.23046},
   Abstract = {<h4>Objectives</h4>We explored whether variation in the
             sweet taste receptor protein T1R3 in primates could
             contribute to differences in sweet taste repertoire among
             species, potentially reflecting coevolution with local
             plants. Specifically, we examined which primates are likely
             to be sweet "tasters" of brazzein, a protein found in the
             fruit of the African plant Pentadiplandra brazzeana that
             tastes intensely sweet to humans, but provides little
             energy. Sweet proteins like brazzein are thought to mimic
             the taste of sugars to entice seed dispersers. We examined
             the evolution of T1R3 and assessed whether primates are
             likely "deceived" by such biochemical mimicry.<h4>Methods</h4>Using
             published and new sequence data for TAS1R3, we characterized
             57 primates and other mammals at the two amino acid sites
             necessary to taste brazzein to determine which species are
             tasters. We further used dN/dS-based methods to look for
             statistical evidence of accelerated evolution in this
             protein across primate lineages.<h4>Results</h4>The taster
             genotype is shared across most catarrhines, suggesting that
             most African primates can be "tricked" into eating and
             dispersing P. brazzeana's seeds for little caloric gain.
             Western gorillas (Gorilla gorilla), however, exhibit derived
             mutations at the two brazzein-critical positions, and
             although fruit is a substantial portion of the western
             gorilla diet, they have not been observed to eat P.
             brazzeana. Our analyses of protein evolution found no
             signature of positive selection on TAS1R3 along the gorilla
             lineage.<h4>Discussion</h4>We propose that the
             gorilla-specific mutations at the TAS1R3 locus encoding T1R3
             could be a counter-adaptation to the false sweet signal of
             brazzein.},
   Doi = {10.1002/ajpa.23046},
   Key = {fds346150}
}

@article{fds346149,
   Author = {Bradley, BJ and Snowdon, CT and McGrew, WC and Lawler, RR and Guevara,
             EE and McIntosh, A and O'Connor, T},
   Title = {Non-human primates avoid the detrimental effects of prenatal
             androgen exposure in mixed-sex litters: combined
             demographic, behavioral, and genetic analyses.},
   Journal = {American Journal of Primatology},
   Volume = {78},
   Number = {12},
   Pages = {1304-1315},
   Year = {2016},
   Month = {December},
   url = {http://dx.doi.org/10.1002/ajp.22583},
   Abstract = {Producing single versus multiple births has important life
             history trade-offs, including the potential benefits and
             risks of sharing a common in utero environment. Sex hormones
             can diffuse through amniotic fluid and fetal membranes, and
             females with male littermates risk exposure to high levels
             of fetal testosterone, which are shown to have masculinizing
             effects and negative fitness consequences in many mammals.
             Whereas most primates give birth to single offspring,
             several New World monkey and strepsirrhine species regularly
             give birth to small litters. We examined whether neonatal
             testosterone exposure might be detrimental to females in
             mixed-sex litters by compiling data from long-term breeding
             records for seven primate species (Saguinus oedipus; Varecia
             variegata, Varecia rubra, Microcebus murinis, Mirza
             coquereli, Cheirogaleus medius, Galago moholi). Litter sex
             ratios did not differ from the expected 1:2:1 (MM:MF:FF for
             twins) and 1:2:2:1 (MMM:MMF:MFF:FFF for triplets). Measures
             of reproductive success, including female survivorship,
             offspring-survivorship, and inter-birth interval, did not
             differ between females born in mixed-sex versus all-female
             litters, indicating that litter-producing non-human
             primates, unlike humans and rodents, show no signs of
             detrimental effects from androgen exposure in mixed sex
             litters. Although we found no evidence for CYP19A1 gene
             duplications-a hypothesized mechanism for coping with
             androgen exposure-aromatase protein evolution shows patterns
             of convergence among litter-producing taxa. That some
             primates have effectively found a way to circumvent a major
             cost of multiple births has implications for understanding
             variation in litter size and life history strategies across
             mammals.},
   Doi = {10.1002/ajp.22583},
   Key = {fds346149}
}

@article{fds346148,
   Author = {Guevara, EE and Chen-Kraus, C and Jacobs, RL and Baden,
             AL},
   Title = {Celebrating fifty years of research at the Duke Lemur
             Center.},
   Journal = {Evolutionary Anthropology},
   Volume = {26},
   Number = {2},
   Pages = {47-48},
   Year = {2017},
   Month = {April},
   url = {http://dx.doi.org/10.1002/evan.21521},
   Doi = {10.1002/evan.21521},
   Key = {fds346148}
}

@article{fds346147,
   Author = {Staes, N and Sherwood, CC and Wright, K and de Manuel, M and Guevara,
             EE and Marques-Bonet, T and Krützen, M and Massiah, M and Hopkins, WD and Ely, JJ and Bradley, BJ},
   Title = {FOXP2 variation in great ape populations offers insight into
             the evolution of communication skills.},
   Journal = {Scientific Reports},
   Volume = {7},
   Number = {1},
   Pages = {16866},
   Year = {2017},
   Month = {December},
   url = {http://dx.doi.org/10.1038/s41598-017-16844-x},
   Abstract = {The gene coding for the forkhead box protein P2 (FOXP2) is
             associated with human language disorders. Evolutionary
             changes in this gene are hypothesized to have contributed to
             the emergence of speech and language in the human lineage.
             Although FOXP2 is highly conserved across most mammals,
             humans differ at two functional amino acid substitutions
             from chimpanzees, bonobos and gorillas, with an additional
             fixed substitution found in orangutans. However, FOXP2 has
             been characterized in only a small number of apes and no
             publication to date has examined the degree of natural
             variation in large samples of unrelated great apes. Here, we
             analyzed the genetic variation in the FOXP2 coding sequence
             in 63 chimpanzees, 11 bonobos, 48 gorillas, 37 orangutans
             and 2 gibbons and observed undescribed variation in great
             apes. We identified two variable polyglutamine
             microsatellites in chimpanzees and orangutans and found
             three nonsynonymous single nucleotide polymorphisms, one in
             chimpanzees, one in gorillas and one in orangutans with
             derived allele frequencies of 0.01, 0.26 and 0.29,
             respectively. Structural and functional protein modeling
             indicate a biochemical effect of the substitution in
             orangutans, and because of its presence solely in the
             Sumatran orangutan species, the mutation may be associated
             with reported population differences in vocalizations.},
   Doi = {10.1038/s41598-017-16844-x},
   Key = {fds346147}
}

@article{fds346308,
   Author = {Guevara, EE and Frankel, DC and Ranaivonasy, J and Richard, AF and Ratsirarson, J and Lawler, RR and Bradley, BJ},
   Title = {A simple, economical protocol for DNA extraction and
             amplification where there is no lab},
   Journal = {Conservation Genetics Resources},
   Volume = {10},
   Number = {1},
   Pages = {119-125},
   Year = {2018},
   Month = {March},
   url = {http://dx.doi.org/10.1007/s12686-017-0758-5},
   Abstract = {Genetic analyses are well suited to address many research
             questions in the study of wild populations, yet species of
             interest often have distributions that are geographically
             distant from molecular laboratories, necessitating
             potentially lengthy transport of biological specimens.
             Performing basic genetic analyses on site would avoid the
             project delays and risks of sample quality decline
             associated with transport, as well as allow original
             specimens to remain in the country of origin. Further,
             diagnostic genetic assays performed in the field could
             provide real-time information allowing for more nimble
             adjustments to research plans and use of resources. To this
             end, we developed protocols for reliably performing
             front-end genetics bench work in the field, without the
             requirements of electricity or permanent shelter. We
             validated these protocols on buccal swabs collected during
             routine capturing of sifaka lemurs (Propithecus verreauxi)
             at Bezà Mahafaly Special Reserve in Southwest Madagascar
             and faecal samples collected from captive sifakas (P.
             coquereli) at the Duke Lemur Center. Our basic protocol
             pipeline involves a chelating resin based DNA extraction
             followed by whole genome amplification or polymerase chain
             reaction using reagents stored at ambient temperature and
             portable, compact equipment powered by a lightweight solar
             panel. We achieved a high success rate (CloseSPigtSPi80%) in
             downstream procedures, demonstrating the promise of such
             protocols for performing basic genetic analyses in a broad
             range of field situations.},
   Doi = {10.1007/s12686-017-0758-5},
   Key = {fds346308}
}

@article{fds346146,
   Author = {Guevara, EE and Lawler, RR},
   Title = {Epigenetic Clocks.},
   Journal = {Evolutionary Anthropology},
   Volume = {27},
   Number = {6},
   Pages = {256-260},
   Year = {2018},
   Month = {November},
   url = {http://dx.doi.org/10.1002/evan.21745},
   Abstract = {Recent research has revealed clock-like patterns of
             epigenetic change across the life span in humans. Models
             describing these epigenetic changes have been dubbed
             "epigenetic clocks," and they can not only predict
             chronological age but also reveal biological age, which
             measures physiological homeostasis and deterioration over
             the life span. Comparative studies of the epigenetic clocks
             of different primate species are likely to provide insights
             into the evolution of life history schedules, as well as
             shed light on the physiological and genetic bases of aging
             and aging-related diseases. Chronological age estimation
             using clock-based calculators may also offer biological
             anthropologists a useful tool for applying to forensic and
             demographic studies.},
   Doi = {10.1002/evan.21745},
   Key = {fds346146}
}

@article{fds346145,
   Author = {Webster, T and Guevara, E and Lawler, R and Bradley,
             B},
   Title = {Successful exome capture and sequencing in lemurs using
             human baits},
   Year = {2018},
   Month = {December},
   url = {http://dx.doi.org/10.1101/490839},
   Abstract = {ABSTRACT Objectives We assessed the efficacy of exome
             capture in lemurs using commercially available human baits.
             Materials and Methods We used two human kits (Nimblegen
             SeqCap EZ Exome Probes v2.0; IDT xGen Exome Research Panel
             v1.0) to capture and sequence the exomes of wild
             Verreaux’s sifakas ( Propithecus verreauxi, n = 8), a
             lemur species distantly related to humans. For comparison,
             we also captured exomes of a primate species more closely
             related to humans ( Macaca mulatta, n= 4). We mapped reads
             to both the human reference assembly and the most closely
             related reference for each species before calling variants.
             We used measures of mapping quality and read coverage to
             compare capture success. Results We observed high and
             comparable mapping qualities for both species when mapped to
             their respective nearest-relative reference genomes. When
             investigating breadth of coverage, we found greater capture
             success in macaques than sifakas using both nearest-relative
             and human assemblies. Exome capture in sifakas was still
             highly successful with more than 90% of annotated coding
             sequence in the sifaka reference genome captured, and 80%
             sequenced to a depth greater than 7x using Nimblegen baits.
             However, this success depended on probe design: the use of
             IDT probes resulted in substantially less callable sequence
             at low-to-moderate depths. Discussion Overall, we
             demonstrate successful exome capture in lemurs using human
             baits, though success differed between kits tested. These
             results indicate that exome capture is an effective and
             economical genomic method of broad utility to evolutionary
             primatologists working across the entire primate
             order.},
   Doi = {10.1101/490839},
   Key = {fds346145}
}

@article{fds346144,
   Author = {Singh, SV and Staes, N and Guevara, EE and Schapiro, SJ and Ely, JJ and Hopkins, WD and Sherwood, CC and Bradley, BJ},
   Title = {Evolution of ASPM coding variation in apes and associations
             with brain structure in chimpanzees.},
   Journal = {Genes, Brain, and Behavior},
   Volume = {18},
   Number = {7},
   Pages = {e12582},
   Year = {2019},
   Month = {September},
   url = {http://dx.doi.org/10.1111/gbb.12582},
   Abstract = {Studying genetic mechanisms underlying primate brain
             morphology can provide insight into the evolution of human
             brain structure and cognition. In humans, loss-of-function
             mutations in the gene coding for ASPM (Abnormal Spindle
             Microtubule Assembly) have been associated with primary
             microcephaly, which is defined by a significantly reduced
             brain volume, intellectual disability and delayed
             development. However, less is known about the effects of
             common ASPM variation in humans and other primates. In this
             study, we characterized the degree of coding variation at
             ASPM in a large sample of chimpanzees (N = 241), and
             examined potential associations between genotype and various
             measures of brain morphology. We identified and genotyped
             five non-synonymous polymorphisms in exons 3 (V588G), 18
             (Q2772K, K2796E, C2811Y) and 27 (I3427V). Using T1-weighted
             magnetic resonance imaging of brains, we measured total
             brain volume, cerebral gray and white matter volume,
             cerebral ventricular volume, and cortical surface area in
             the same chimpanzees. We found a potential association
             between ASPM V588G genotype and cerebral ventricular volume
             but not with the other measures. Additionally, we found that
             chimpanzee, bonobo, and human lineages each independently
             show a signature of accelerated ASPM protein evolution.
             Overall, our results suggest the potential effects of ASPM
             variation on cerebral cortical development, and emphasize
             the need for further functional studies. These results are
             the first evidence suggesting ASPM variation might play a
             role in shaping natural variation in brain structure in
             nonhuman primates.},
   Doi = {10.1111/gbb.12582},
   Key = {fds346144}
}

@article{fds352546,
   Author = {Guevara, EE and Lawler, RR and Staes, N and White, CM and Sherwood, CC and Ely, JJ and Hopkins, WD and Bradley, BJ},
   Title = {Age-associated epigenetic change in chimpanzees and
             humans.},
   Journal = {Philosophical Transactions of the Royal Society of London.
             Series B, Biological Sciences},
   Volume = {375},
   Number = {1811},
   Pages = {20190616},
   Year = {2020},
   Month = {November},
   url = {http://dx.doi.org/10.1098/rstb.2019.0616},
   Abstract = {Methylation levels have been shown to change with age at
             sites across the human genome. Change at some of these sites
             is so consistent across individuals that it can be used as
             an 'epigenetic clock' to predict an individual's
             chronological age to within a few years. Here, we examined
             how the pattern of epigenetic ageing in chimpanzees compares
             with humans. We profiled genome-wide blood methylation
             levels by microarray for 113 samples from 83 chimpanzees
             aged 1-58 years (26 chimpanzees were sampled at multiple
             ages during their lifespan). Many sites (greater than 65
             000) showed significant change in methylation with age and
             around one-third (32%) of these overlap with sites showing
             significant age-related change in humans. At over 80% of
             sites showing age-related change in both species,
             chimpanzees displayed a significantly faster rate of
             age-related change in methylation than humans. We also built
             a chimpanzee-specific epigenetic clock that predicted age in
             our test dataset with a median absolute deviation from known
             age of only 2.4 years. However, our chimpanzee clock showed
             little overlap with previously constructed human clocks.
             Methylation at CpGs comprising our chimpanzee clock showed
             moderate heritability. Although the use of a human
             microarray for profiling chimpanzees biases our results
             towards regions with shared genomic sequence between the
             species, nevertheless, our results indicate that there is
             considerable conservation in epigenetic ageing between
             chimpanzees and humans, but also substantial divergence in
             both rate and genomic distribution of ageing-associated
             sites. This article is part of the theme issue 'Evolution of
             the primate ageing process'.},
   Doi = {10.1098/rstb.2019.0616},
   Key = {fds352546}
}

@article{fds355361,
   Author = {Staes, N and Guevara, EE and Helsen, P and Eens, M and Stevens,
             JMG},
   Title = {The Pan social brain: An evolutionary history of
             neurochemical receptor genes and their potential impact on
             sociocognitive differences.},
   Journal = {Journal of Human Evolution},
   Volume = {152},
   Pages = {102949},
   Year = {2021},
   Month = {March},
   url = {http://dx.doi.org/10.1016/j.jhevol.2021.102949},
   Abstract = {Humans have unique cognitive capacities that, compared with
             apes, are not only simply expressed as a higher level of
             general intelligence, but also as a quantitative difference
             in sociocognitive skills. Humans' closest living relatives,
             bonobos (Pan paniscus), and chimpanzees (Pan troglodytes),
             show key between-species differences in social cognition
             despite their close phylogenetic relatedness, with bonobos
             arguably showing greater similarities to humans. To better
             understand the evolution of these traits, we investigate the
             neurochemical mechanisms underlying sociocognitive skills by
             focusing on variation in genes encoding proteins with
             well-documented roles in mammalian social cognition: the
             receptors for vasopressin (AVPR1A), oxytocin (OXTR),
             serotonin (HTR1A), and dopamine (DRD2). Although these genes
             have been well studied in humans, little is known about
             variation in these genes that may underlie differences in
             social behavior and cognition in apes. We comparatively
             analyzed sequence data for 33 bonobos and 57 chimpanzees,
             together with orthologous sequence data for other apes. In
             all four genes, we describe genetic variants that alter the
             amino acid sequence of the respective receptors, raising the
             possibility that ligand binding or signal transduction may
             be impacted. Overall, bonobos show 57% more fixed
             substitutions than chimpanzees compared with the ancestral
             Pan lineage. Chimpanzees, show 31% more polymorphic coding
             variation, in line with their larger historical effective
             population size estimates and current wider distribution. An
             extensive literature review comparing allelic changes in Pan
             with known human behavioral variants revealed evidence of
             homologous evolution in bonobos and humans (OXTR
             rs4686301(T) and rs237897(A)), while humans and chimpanzees
             shared OXTR rs2228485(A), DRD2 rs6277(A), and DRD2
             rs11214613(A) to the exclusion of bonobos. Our results offer
             the first in-depth comparison of neurochemical receptor gene
             variation in Pan and put forward new variants for future
             behavior-genotype association studies in apes, which can
             increase our understanding of the evolution of social
             cognition in modern humans.},
   Doi = {10.1016/j.jhevol.2021.102949},
   Key = {fds355361}
}

@article{fds355947,
   Author = {Guevara, EE and Webster, TH and Lawler, RR and Bradley, BJ and Greene,
             LK and Ranaivonasy, J and Ratsirarson, J and Harris, RA and Liu, Y and Murali, S and Raveendran, M and Hughes, DST and Muzny, DM and Yoder, AD and Worley, KC and Rogers, J},
   Title = {Comparative genomic analysis of sifakas (Propithecus)
             reveals selection for folivory and high heterozygosity
             despite endangered status.},
   Journal = {Science Advances},
   Volume = {7},
   Number = {17},
   Pages = {eabd2274},
   Year = {2021},
   Month = {April},
   url = {http://dx.doi.org/10.1126/sciadv.abd2274},
   Abstract = {Sifakas (genus Propithecus) are critically endangered,
             large-bodied diurnal lemurs that eat leaf-based diets and
             show corresponding anatomical and microbial adaptations to
             folivory. We report on the genome assembly of Coquerel's
             sifaka (P. coquereli) and the resequenced genomes of
             Verreaux's (P. verreauxi), the golden-crowned (P.
             tattersalli), and the diademed (P. diadema) sifakas. We find
             high heterozygosity in all sifakas compared with other
             primates and endangered mammals. Demographic reconstructions
             nevertheless suggest declines in effective population size
             beginning before human arrival on Madagascar. Comparative
             genomic analyses indicate pervasive accelerated evolution in
             the ancestral sifaka lineage affecting genes in several
             complementary pathways relevant to folivory, including
             nutrient absorption and xenobiotic and fatty acid
             metabolism. Sifakas show convergent evolution at the level
             of the pathway, gene family, gene, and amino acid
             substitution with other folivores. Although sifakas have
             relatively generalized diets, the physiological challenges
             of habitual folivory likely led to strong
             selection.},
   Doi = {10.1126/sciadv.abd2274},
   Key = {fds355947}
}

@article{fds356173,
   Author = {Guevara, EE and Hopkins, WD and Hof, PR and Ely, JJ and Bradley, BJ and Sherwood, CC},
   Title = {Comparative analysis reveals distinctive epigenetic features
             of the human cerebellum.},
   Journal = {Plos Genetics},
   Volume = {17},
   Number = {5},
   Pages = {e1009506},
   Year = {2021},
   Month = {May},
   url = {http://dx.doi.org/10.1371/journal.pgen.1009506},
   Abstract = {Identifying the molecular underpinnings of the neural
             specializations that underlie human cognitive and behavioral
             traits has long been of considerable interest. Much research
             on human-specific changes in gene expression and epigenetic
             marks has focused on the prefrontal cortex, a brain
             structure distinguished by its role in executive functions.
             The cerebellum shows expansion in great apes and is gaining
             increasing attention for its role in motor skills and
             cognitive processing, including language. However,
             relatively few molecular studies of the cerebellum in a
             comparative evolutionary context have been conducted. Here,
             we identify human-specific methylation in the lateral
             cerebellum relative to the dorsolateral prefrontal cortex,
             in a comparative study with chimpanzees (Pan troglodytes)
             and rhesus macaques (Macaca mulatta). Specifically, we
             profiled genome-wide methylation levels in the three species
             for each of the two brain structures and identified
             human-specific differentially methylated genomic regions
             unique to each structure. We further identified which
             differentially methylated regions (DMRs) overlap likely
             regulatory elements and determined whether associated genes
             show corresponding species differences in gene expression.
             We found greater human-specific methylation in the
             cerebellum than the dorsolateral prefrontal cortex, with
             differentially methylated regions overlapping genes involved
             in several conditions or processes relevant to human
             neurobiology, including synaptic plasticity, lipid
             metabolism, neuroinflammation and neurodegeneration, and
             neurodevelopment, including developmental disorders.
             Moreover, our results show some overlap with those of
             previous studies focused on the neocortex, indicating that
             such results may be common to multiple brain structures.
             These findings further our understanding of the cerebellum
             in human brain evolution.},
   Doi = {10.1371/journal.pgen.1009506},
   Key = {fds356173}
}

@article{fds366563,
   Author = {Guevara, EE and Greene, LK and Blanco, MB and Farmer, C and Ranaivonasy,
             J and Ratsirarson, J and Mahefarisoa, KL and Rajaonarivelo, T and Rakotondrainibe, HH and Junge, RE and Williams, CV and Rambeloson, E and Rasoanaivo, HA and Rahalinarivo, V and Andrianandrianina, LH and Clayton, JB and Rothman, RS and Lawler, RR and Bradley, BJ and Yoder,
             AD},
   Title = {Molecular adaptation to folivory and the conservation
             implications for Madagascar’s lemurs},
   Year = {2021},
   Month = {July},
   url = {http://dx.doi.org/10.1101/2021.07.06.451309},
   Abstract = {<jats:title>Abstract</jats:title><jats:p>Folivory evolved
             independently at least three times over the last 40 million
             years among Madagascar’s lemurs. Many extant lemuriform
             folivores exist in sympatry in Madagascar’s remaining
             forests. These species avoid feeding competition by adopting
             different dietary strategies within folivory, reflected in
             behavioral, morphological, and microbiota diversity across
             species. These conditions make lemurs an ideal study system
             for understanding adaptation to leaf-eating. Most folivorous
             lemurs are also highly endangered. The significance of
             folivory for conservation outlook is complex. Though
             generalist folivores may be relatively well equipped to
             survive habitat disturbance, specialist folivores occupying
             narrow dietary niches may be less resilient. Characterizing
             the genetic bases of adaptation to folivory across species
             and lineages can provide insights into their differential
             physiology and potential to resist habitat change. We
             recently reported accelerated genetic change
             in<jats:italic>RNASE1</jats:italic>, a gene encoding an
             enzyme (RNase 1) involved in molecular adaptation in
             mammalian folivores, including various monkeys and sifakas
             (genus<jats:italic>Propithecus</jats:italic>; family
             Indriidae). Here, we sought to assess whether other lemurs,
             including phylogenetically and ecologically diverse
             folivores, might show parallel adaptive change
             in<jats:italic>RNASE1</jats:italic>that could underlie a
             capacity for efficient folivory. We characterized<jats:italic>RNASE1</jats:italic>in
             21 lemur species representing all five families and members
             of the three extant folivorous lineages: 1) bamboo lemurs
             (family Lemuridae), 2) sportive lemurs (family
             Lepilemuridae), and 3) indriids (family Indriidae). We found
             pervasive sequence change in<jats:italic>RNASE1</jats:italic>across
             all indriids, a d<jats:sub>N</jats:sub>/d<jats:sub>S</jats:sub>value
             &gt; 3 in this clade, and evidence for shared change in
             isoelectric point, indicating altered enzymatic function.
             Sportive and bamboo lemurs, in contrast, showed more modest
             sequence change. The greater change in indriids may reflect
             a shared strategy emphasizing complex gut morphology and
             microbiota to facilitate folivory. This case study
             illustrates how genetic analysis may reveal differences in
             functional traits that could influence species’ ecology
             and, in turn, their resilience to habitat change. Moreover,
             our results support the contention that not all primate
             folivores are built the same and highlight the need to avoid
             generalizations about dietary guild in considering
             conservation outlook, particularly in lemurs where such
             diversity in folivory has probably led to extensive
             specialization via niche partitioning.</jats:p>},
   Doi = {10.1101/2021.07.06.451309},
   Key = {fds366563}
}

@article{fds363984,
   Author = {Guevara, EE and Hopkins, WD and Hof, PR and Ely, JJ and Bradley, BJ and Sherwood, CC},
   Title = {Epigenetic ageing of the prefrontal cortex and cerebellum in
             humans and chimpanzees.},
   Journal = {Epigenetics},
   Volume = {17},
   Number = {12},
   Pages = {1774-1785},
   Year = {2022},
   Month = {December},
   url = {http://dx.doi.org/10.1080/15592294.2022.2080993},
   Abstract = {Epigenetic age has emerged as an important biomarker of
             biological ageing. It has revealed that some tissues age
             faster than others, which is vital to understanding the
             complex phenomenon of ageing and developing effective
             interventions. Previous studies have demonstrated that
             humans exhibit heterogeneity in pace of epigenetic ageing
             among brain structures that are consistent with differences
             in structural and microanatomical deterioration. Here, we
             add comparative data on epigenetic brain ageing for
             chimpanzees, humans' closest relatives. Such comparisons can
             further our understanding of which aspects of human ageing
             are evolutionarily conserved or specific to our species,
             especially given that humans are distinguished by a long
             lifespan, large brain, and, potentially, more severe
             neurodegeneration with age. Specifically, we investigated
             epigenetic ageing of the dorsolateral prefrontal cortex and
             cerebellum, of humans and chimpanzees by generating
             genome-wide CpG methylation data and applying established
             epigenetic clock algorithms to produce estimates of
             biological age for these tissues. We found that both species
             exhibit relatively slow epigenetic ageing in the brain
             relative to blood. Between brain structures, humans show a
             faster rate of epigenetic ageing in the dorsolateral
             prefrontal cortex compared to the cerebellum, which is
             consistent with previous findings. Chimpanzees, in contrast,
             show comparable rates of epigenetic ageing in the two brain
             structures. Greater epigenetic change in the human
             dorsolateral prefrontal cortex compared to the cerebellum
             may reflect both the protracted development of this
             structure in humans and its greater age-related
             vulnerability to neurodegenerative pathology.},
   Doi = {10.1080/15592294.2022.2080993},
   Key = {fds363984}
}

@article{fds373899,
   Author = {Guevara, E and Gopalan, S and Massey, DJ and Adegboyega, M and Zhou, W and Solis, A and Anaya, AD and Churchill, SE and Feldblum, J and Lawler,
             RR},
   Title = {Getting it right: Teaching undergraduate biology to
             undermine racial essentialism.},
   Journal = {Biology Methods and Protocols},
   Volume = {8},
   Number = {1},
   Pages = {bpad032},
   Publisher = {Oxford University Press (OUP)},
   Year = {2023},
   Month = {January},
   url = {http://dx.doi.org/10.1093/biomethods/bpad032},
   Abstract = {How we teach human genetics matters for social equity. The
             biology curriculum appears to be a crucial locus of
             intervention for either reinforcing or undermining students'
             racial essentialist views. The Mendelian genetic models
             dominating textbooks, particularly in combination with
             racially inflected language sometimes used when teaching
             about monogenic disorders, can increase middle and high
             school students' racial essentialism and opposition to
             policies to increase equity. These findings are of
             particular concern given the increasing spread of racist
             misinformation online and the misappropriation of human
             genomics research by white supremacists, who take advantage
             of low levels of genetics literacy in the general public.
             Encouragingly, however, teaching updated information about
             the geographical distribution of human genetic variation and
             the complex, multifactorial basis of most human traits,
             reduces students' endorsement of racial essentialism. The
             genetics curriculum is therefore a key tool in combating
             misinformation and scientific racism. Here, we describe a
             framework and example teaching materials for teaching
             students key concepts in genetics, human evolutionary
             history, and human phenotypic variation at the undergraduate
             level. This framework can be flexibly applied in biology and
             anthropology classes and adjusted based on time
             availability. Our goal is to provide undergraduate-level
             instructors with varying levels of expertise with a set of
             evidence-informed tools for teaching human genetics to
             combat scientific racism, including an evolving set of
             instructional resources, as well as learning goals and
             pedagogical approaches. Resources can be found at
             https://noto.li/YIlhZ5. Additionally, we hope to generate
             conversation about integrating modern genetics into the
             undergraduate curriculum, in light of recent findings about
             the risks and opportunities associated with teaching
             genetics.},
   Doi = {10.1093/biomethods/bpad032},
   Key = {fds373899}
}


%% Papers Presented/Symposia/Abstracts   
@article{fds346154,
   Author = {Guevara, EEG and Steiper, ME},
   Title = {Analysis of multi-locus sequence data indicates complex
             speciation in the evolutionary history of the
             Papionina},
   Journal = {American Journal of Physical Anthropology},
   Volume = {150},
   Pages = {139-140},
   Publisher = {WILEY-BLACKWELL},
   Year = {2013},
   Month = {January},
   Key = {fds346154}
}


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