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| Publications of James M Provenzale :chronological alphabetical combined listing:
%% Papers Published
@article{fds192781,
Author = {RL Holt and JM Provenzale and A Veerapandiyan and WJ Moon, MD De
Bellis and S Leonard and WB Gallentine and GA Grant and H Egger and AW
Song, MA Mikati},
Title = {Structural connectivity of the frontal lobe in children with
drug-resistant partial epilepsy.},
Journal = {Epilepsy & behavior : E&B},
Volume = {21},
Number = {1},
Pages = {65-70},
Year = {2011},
Month = {May},
ISSN = {1525-5069},
url = {http://dx.doi.org/10.1016/j.yebeh.2011.03.016},
Abstract = {The superior longitudinal fasciculus (SLF) II and cingulum
are two white matter tracts important for attention and
other frontal lobe functions. These functions are often
disturbed in children with drug-resistant (DR) partial
epilepsy, even when no abnormalities are seen on
conventional MRI. We set out to determine whether
abnormalities in these structures might be depicted on
diffusion tensor imaging (DTI) studies in the absence of
abnormalities on conventional MRI. We compared the DTI
findings of 12 children with DR partial epilepsy with those
of 12 age- and gender-matched controls. We found that the
SLF II fractional anisotropy (FA) values of the patients
were significantly lower than those of the controls (means:
0.398±0.057 and 0.443±0.059, respectively, P=0.002).
Similarly, apparent diffusion coefficient (ADC) and parallel
diffusivity values for SLF II were also significantly lower
in the patients. There were no differences in the FA and ADC
values of the cingulum. Our findings are consistent with
abnormal structural connectivity of the frontal lobe in
children with DR partial epilepsy and provide a possible
explanation for the previously reported functional
abnormalities related to the SLF II in these
patients.},
Language = {eng},
Doi = {10.1016/j.yebeh.2011.03.016},
Key = {fds192781}
}
@article{fds192785,
Author = {LR Folio and TV Fischer and PJ Shogan and MI Frew and PS Kang and R Bunger and JM Provenzale},
Title = {CT-based ballistic wound path identification and trajectory
analysis in anatomic ballistic phantoms.},
Journal = {Radiology},
Volume = {258},
Number = {3},
Pages = {923-9},
Year = {2011},
Month = {March},
ISSN = {1527-1315},
url = {http://dx.doi.org/10.1148/radiol.10100534},
Keywords = {Feasibility Studies • Humans • Leg Injuries •
Phantoms, Imaging • Radiographic Image Interpretation,
Computer-Assisted • Tomography, X-Ray Computed •
Wounds, Gunshot • methods* • radiography •
radiography*},
Abstract = {OBJECTIVE: To evaluate the accuracy of computed tomography
(CT)-based ballistic wound path identification in phantoms
by determining the agreement between actual shooting angles
and both trajectory angles measured with a picture archiving
and communication system (PACS) angle tool and angles
calculated from x, y, z coordinates of the entrance and exit
points. METHODS: In this institutional review board-approved
model study, two simulated legs were shot by a trained
marksman from 50 yards at six clinometer-measured angles
with a 0.30-06 rifle and then scanned at multidetector CT.
Radiologists measured the wound path angles on paracoronal
reformations by using a PACS angle tool. Observers
determined the Cartesian coordinates of the entrance and
exit points of the wound paths on axial CT images by using
detailed instructions. Angles were calculated from these
coordinates by using a computer arctangent function.
Agreement between the angles was evaluated with Bland-Altman
plots. Means, ranges, and standard deviations of the angles
also were determined. RESULTS: Radiologists identified all
six wound paths on the CT images. The PACS tool-based
measured and coordinate-based calculated angles were within
5° of the shooting angles. Results indicated that in larger
study populations, one can be 91% confident that future
coordinate-based angle calculations will differ from the
actual shooting angle by no more than 5° and 95% confident
that PACS tool-based angle measurements will differ from the
actual shooting angles by no more than 4.5°. One can be 95%
confident that future coordinate-based angle calculations
will differ from PACS angle measurements by no more than
4.02°. CONCLUSIONS: Study results demonstrated the
feasibility of consistent wound path identification and the
accuracy of trajectory angle determination in models with
use of multidetector CT.},
Language = {eng},
Doi = {10.1148/radiol.10100534},
Key = {fds192785}
}
@article{fds192794,
Author = {PI Dickson and AR Pariser and SC Groft and RW Ishihara and DE McNeil and D
Tagle, DJ Griebel and SG Kaler and JW Mink and EG Shapiro and KJ
Bjoraker, L Krivitzky and JM Provenzale and A Gropman and P Orchard and G Raymond and BH Cohen and RD Steiner and SF Goldkind and RM Nelson and E
Kakkis, MC Patterson},
Title = {Research challenges in central nervous system manifestations
of inborn errors of metabolism.},
Journal = {Molecular genetics and metabolism},
Volume = {102},
Number = {3},
Pages = {326-38},
Year = {2011},
Month = {March},
ISSN = {1096-7206},
url = {http://dx.doi.org/10.1016/j.ymgme.2010.11.164},
Keywords = {Animals • Biomedical Research* • Central Nervous
System* • Clinical Trials as Topic • Humans •
Metabolism, Inborn Errors • Rare Diseases •
diagnosis* • ethics • pathology •
physiopathology • therapy • therapy* •
trends},
Abstract = {The Research Challenges in CNS Manifestations of Inborn
Errors of Metabolism workshop was designed to address
challenges in translating potential therapies for these rare
disorders, and to highlight novel therapeutic strategies and
innovative approaches to CNS delivery, assessment of effects
and directions for the future in the treatment of these
diseases. Therapies for the brain in inborn errors represent
some of the greatest challenges to translational research
due to the special properties of the brain, and of inborn
errors themselves. This review covers the proceedings of
this workshop as submitted by participants. Scientific,
ethical and regulatory issues are discussed, along with ways
to measure outcomes and the conduct of clinical trials.
Participants included regulatory and funding agencies,
clinicians, scientists, industry and advocacy
groups.},
Language = {eng},
Doi = {10.1016/j.ymgme.2010.11.164},
Key = {fds192794}
}
@article{fds192779,
Author = {JM Provenzale and B Sarikaya and L Hacein-Bey and M
Wintermark},
Title = {Causes of misinterpretation of cross-sectional imaging
studies for dissection of the craniocervical
arteries.},
Journal = {AJR. American journal of roentgenology},
Volume = {196},
Number = {1},
Pages = {45-52},
Year = {2011},
Month = {January},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.10.5384},
Keywords = {Aneurysm, Dissecting • Carotid Arteries* •
Cerebral Angiography • False Negative Reactions •
False Positive Reactions • Humans • Magnetic
Resonance Angiography • Magnetic Resonance Imaging
• Tomography, X-Ray Computed • Vertebral Artery*
• diagnosis*},
Abstract = {OBJECTIVE: This review presents some of the more common
causes of false-positive and false-negative interpretations
of cross-sectional imaging studies showing, or designed to
show, dissection of the carotid or vertebral arteries.
CONCLUSION: Dissection of the craniocervical arteries is a
diagnosis that can be very difficult on cross-sectional
imaging studies such as CT angiography, MRI, and MR
angiography.},
Language = {eng},
Doi = {10.2214/AJR.10.5384},
Key = {fds192779}
}
@article{fds192783,
Author = {JM Provenzale and PG Kranz},
Title = {Dural sinus thrombosis: sources of error in image
interpretation.},
Journal = {AJR. American journal of roentgenology},
Volume = {196},
Number = {1},
Pages = {23-31},
Year = {2011},
Month = {January},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.10.5323},
Keywords = {Contrast Media • False Negative Reactions • False
Positive Reactions • Humans • Magnetic Resonance
Angiography • Sinus Thrombosis, Intracranial •
Tomography, X-Ray Computed • diagnosis* •
diagnostic use},
Abstract = {OBJECTIVE: The purpose of this article is to bring some of
the potential causes of false-positive and false-negative
interpretations of dural sinus thrombosis (DST) on
cross-section imaging studies to the attention of
radiologists. CONCLUSION: The prompt diagnosis of DST can be
important in many cases and a false-positive diagnosis can
cause a delay in establishing the correct diagnosis as well
as lead to implementation of inappropriate therapy. We hope
that this article helps to reduce the number of such cases
in the daily practice of the reader.},
Language = {eng},
Doi = {10.2214/AJR.10.5323},
Key = {fds192783}
}
@article{fds192788,
Author = {L Hacein-Bey and JM Provenzale},
Title = {Current imaging assessment and treatment of intracranial
aneurysms.},
Journal = {AJR. American journal of roentgenology},
Volume = {196},
Number = {1},
Pages = {32-44},
Year = {2011},
Month = {January},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.10.5329},
Keywords = {Angiography, Digital Subtraction • Cerebral Angiography
• Endovascular Procedures • Humans •
Intracranial Aneurysm • Magnetic Resonance Angiography
• Magnetic Resonance Imaging • Tomography, X-Ray
Computed • diagnosis* • methods • methods*
• therapy*},
Abstract = {OBJECTIVE: This article reviews current neuroimaging
techniques used for screening, diagnosis, and follow-up of
patients with intracranial aneurysms as well as
neuroendovascular therapeutic options available to patients.
CONCLUSION: The diagnosis and management of intracranial
aneurysms have evolved dramatically in the past 20 years. MR
angiography and CT angiography allow radiologists to
reliably and noninvasively diagnose most intracranial
aneurysms. Nonoperative endovascular techniques for treating
intracranial aneurysms are now making treatment increasingly
safer and more effective.},
Language = {eng},
Doi = {10.2214/AJR.10.5329},
Key = {fds192788}
}
@article{fds192790,
Author = {C Leiva-Salinas and JM Provenzale and M Wintermark},
Title = {Responses to the 10 most frequently asked questions about
perfusion CT.},
Journal = {AJR. American journal of roentgenology},
Volume = {196},
Number = {1},
Pages = {53-60},
Year = {2011},
Month = {January},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.10.5705},
Keywords = {Brain Ischemia • Cerebral Angiography •
Cerebrovascular Circulation • Decision Making •
Humans • Magnetic Resonance Angiography • Magnetic
Resonance Imaging • Radiographic Image Interpretation,
Computer-Assisted • Software • Stroke •
Tomography, X-Ray Computed • methods* •
radiography*},
Abstract = {OBJECTIVE: The objective of this article is to address the
10 most frequently asked questions radiologists face when
planning, performing, processing, and interpreting a
perfusion CT study in a patient with clinical suspicion of
acute ischemic stroke. CONCLUSION: It is important for
radiologists using PCT for stroke imaging to be familiar
with the perfusion software used at their institution, with
the parameters that can be selected during the
post-processing and how these may influence the PCT
results.},
Language = {eng},
Doi = {10.2214/AJR.10.5705},
Key = {fds192790}
}
@article{fds192782,
Author = {JM Provenzale},
Title = {Revising a manuscript: ten principles to guide success for
publication.},
Journal = {AJR. American journal of roentgenology},
Volume = {195},
Number = {6},
Pages = {W382-7},
Year = {2010},
Month = {December},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.10.5553},
Keywords = {Decision Making • Guidelines as Topic • Humans
• Peer Review, Research* • Periodicals as Topic
• Publication Bias • Publications* •
Publishing • Writing*},
Abstract = {OBJECTIVE: The process of revising a manuscript and
successfully responding to the comments of reviewers and the
Editor can be difficult. This article provides some
practical steps to guide authors in this task and attain
publication of their manuscript. CONCLUSION: Following the
principles outlined in this article will enable authors to
successfully meet the challenges of manuscript revision and
hasten the route to publication.},
Language = {eng},
Doi = {10.2214/AJR.10.5553},
Key = {fds192782}
}
@article{fds192792,
Author = {JM Provenzale and J Isaacson and S Chen and S Stinnett and C
Liu},
Title = {Correlation of apparent diffusion coefficient and fractional
anisotropy values in the developing infant
brain.},
Journal = {AJR. American journal of roentgenology},
Volume = {195},
Number = {6},
Pages = {W456-62},
Year = {2010},
Month = {December},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.10.4886},
Keywords = {Anisotropy • Brain • Diffusion Magnetic Resonance
Imaging • Humans • Image Processing,
Computer-Assisted • Infant • Infant, Newborn
• growth & development* • methods*},
Abstract = {OBJECTIVE: The purpose of our study was to correlate
decrease in apparent diffusion coefficient (ADC) and
increase in fractional anisotropy (FA) in various white
matter (WM) regions using diffusion tenor imaging (DTI)
within the first year of life. METHODS: We performed DTI on
53 infants and measured FA and ADC within 10 WM regions
important in brain development. For each region, we
calculated the slope of ADC as a function of FA, the
correlation coefficient (r) and correlation of determination
(r(2)). We performed a group analysis of r values and
r(2)values for six WM regions primarily composed of crossing
fibers and four regions primarily having parallel fibers.
Upon finding that a strong correlation of FA with age
existed, we adjusted for age and calculated partial
correlation coefficients. RESULTS: Slopes of FA versus ADC
ranged from -1.00711 to -1.67592 (p < 0.05); r values ranged
from -0.81 to -0.50 and r(2) values from 0.25 to 0.66. The
four greatest r(2) values were within WM regions having
large numbers of crossing fibers and the three lowest r(2)
values were in regions having predominantly parallel fibers.
After adjusting for age, slopes ranged from -1.08095 to
0.09612 (p < 0.05 in five cases); partial correlation
coefficients ranged from -0.49 to 0.03 and r(2) values from
0.31 to 0.79. The highest partial correlation coefficients
were then relatively equally distributed between the two
types of WM regions. CONCLUSIONS: In various regions, FA and
ADC evolved with differing degrees of correlation. We found
a strong influence of age on the relationship between FA and
ADC.},
Language = {eng},
Doi = {10.2214/AJR.10.4886},
Key = {fds192792}
}
@article{fds192793,
Author = {JM Provenzale},
Title = {Imaging findings of structural causes of epilepsy in
children: a guide for the radiologist in the emergency
room.},
Journal = {Emergency radiology},
Volume = {17},
Number = {6},
Pages = {479-86},
Year = {2010},
Month = {November},
ISSN = {1438-1435},
url = {http://dx.doi.org/10.1007/s10140-010-0884-9},
Keywords = {Arteriovenous Malformations • Brain Neoplasms •
Cerebral Cortex • Child • Diagnostic Imaging*
• Emergency Service, Hospital* • Epilepsy •
Hemangioma, Cavernous • Hippocampus • Humans
• Magnetic Resonance Imaging • Neurocutaneous
Syndromes • Tomography, X-Ray Computed •
abnormalities • complications • diagnosis •
diagnosis* • etiology* • pathology},
Abstract = {Evaluation of the child with epilepsy is a relatively common
indication for imaging in the emergency room setting. This
room outlines some of the more important imaging features of
causes of epilepsy in children.},
Language = {eng},
Doi = {10.1007/s10140-010-0884-9},
Key = {fds192793}
}
@article{fds192786,
Author = {AM Mohs and MC Mancini and S Singhal and JM Provenzale and B
Leyland-Jones, MD Wang and S Nie},
Title = {Hand-held Spectroscopic Device for In Vivo and
Intraoperative Tumor Detection: Contrast Enhancement,
Detection Sensitivity, and Tissue Penetration.},
Journal = {Analytical chemistry},
Year = {2010},
Month = {October},
ISSN = {1520-6882},
url = {http://dx.doi.org/10.1021/ac102058k},
Abstract = {Surgery is one of the most effective and widely used
procedures in treating human cancers, but a major problem is
that the surgeon often fails to remove the entire tumor,
leaving behind tumor-positive margins, metastatic lymph
nodes, and/or satellite tumor nodules. Here we report the
use of a hand-held spectroscopic pen device (termed
SpectroPen) and near-infrared contrast agents for
intraoperative detection of malignant tumors, based on
wavelength-resolved measurements of fluorescence and
surface-enhanced Raman scattering (SERS) signals. The
SpectroPen utilizes a near-infrared diode laser (emitting at
785 nm) coupled to a compact head unit for light excitation
and collection. This pen-shaped device effectively removes
silica Raman peaks from the fiber optics and attenuates the
reflected excitation light, allowing sensitive analysis of
both fluorescence and Raman signals. Its overall performance
has been evaluated by using a fluorescent contrast agent
(indocyanine green, or ICG) as well as a surface-enhanced
Raman scattering (SERS) contrast agent (pegylated colloidal
gold). Under in vitro conditions, the detection limits are
approximately 2-5 × 10(-11) M for the indocyanine dye and
0.5-1 × 10(-13) M for the SERS contrast agent. Ex vivo
tissue penetration data show attenuated but resolvable
fluorescence and Raman signals when the contrast agents are
buried 5-10 mm deep in fresh animal tissues. In vivo studies
using mice bearing bioluminescent 4T1 breast tumors further
demonstrate that the tumor borders can be precisely detected
preoperatively and intraoperatively, and that the contrast
signals are strongly correlated with tumor bioluminescence.
After surgery, the SpectroPen device permits further
evaluation of both positive and negative tumor margins
around the surgical cavity, raising new possibilities for
real-time tumor detection and image-guided
surgery.},
Language = {ENG},
Doi = {10.1021/ac102058k},
Key = {fds192786}
}
@article{fds192787,
Author = {JM Provenzale},
Title = {Imaging evaluation of the patient with worst headache of
life--it's not all subarachnoid hemorrhage.},
Journal = {Emergency radiology},
Volume = {17},
Number = {5},
Pages = {403-12},
Year = {2010},
Month = {September},
ISSN = {1438-1435},
url = {http://dx.doi.org/10.1007/s10140-010-0882-y},
Keywords = {Algorithms • Diagnostic Errors • Diagnostic
Imaging* • Emergency Medicine • Female •
Headache* • Humans • Male • Meningitis •
Subarachnoid Hemorrhage • diagnosis • radiography
• radiography*},
Abstract = {The radiologist working in the emergency radiology setting
is often faced with evaluating imaging findings of the
patient whose chief complaint is that of the worst headache
of life. The diagnosis of subarachnoid hemorrhage (SAH) is
usually the initial consideration before imaging is
performed and, appropriately, must be quickly diagnosed.
However, a number of entities can simulate SAH on imaging
studies. Those entities are presented here. In addition, a
number of disease processes other than SAH can produce worst
headache of life. Some of the most important entities, and
their CT and MR findings, are reviewed here.},
Language = {eng},
Doi = {10.1007/s10140-010-0882-y},
Key = {fds192787}
}
@article{fds192791,
Author = {JM Provenzale and SS Stinnett and ST Engelter},
Title = {Use of decrease in apparent diffusion coefficient values to
predict infarct age.},
Journal = {Emergency radiology},
Volume = {17},
Number = {5},
Pages = {391-5},
Year = {2010},
Month = {September},
ISSN = {1438-1435},
url = {http://dx.doi.org/10.1007/s10140-010-0869-8},
Keywords = {Adolescent • Adult • Age of Onset • Aged
• Aged, 80 and over • Brain Infarction •
Diffusion • Diffusion Magnetic Resonance Imaging •
False Positive Reactions • Female • Humans •
Male • Middle Aged • Retrospective Studies •
diagnosis* • methods*},
Abstract = {The purpose of the study was to determine the ability to
predict infarct age based on decrease in apparent diffusion
coefficient (ADC) values. We retrospectively identified 94
individuals (age range 16 years to 91 years; mean 63.7 +
14.1 years) who underwent magnetic resonance
diffusion-weighted imaging at our institution over a course
of 14 months whose infarct age could be reliably determined
within 1 h. A single observer measured ADC values within the
center of the infarct and compared them against values in
contralateral normal tissue. We examined the ability of four
ADC decrease thresholds (i.e., >50%, >40%, >30%, and >20%)
to predict infarct age of <24 and <48 h. Levels of ADC
decrease in infarcts were as follows: <20%, n = 9; 20-29%, n
= 21; 30-39%, n = 25; 40-49%, n = 23; >50%, n = 16. For
prediction of infarct age <24 h, sensitivity for the four
ADC decrease thresholds ranged from 25% to 94%, specificity
ranged from 10% to 85%, positive predictive value (PPV)
ranged from 18% to 25%, and negative predictive value (NPV)
ranged from 85% to 89%. For prediction of infarct age <48 h,
sensitivity ranged from 23% to 98%, specificity ranged from
15% to 87%, PPV ranged from 46% to 56%, and NPV ranged from
60% to 89%. Test performance characteristics for predicting
infarct age of <24 and <48 h were relatively poor. In
particular, PPV was very low for predicting infarcts <24 h
old.},
Language = {eng},
Doi = {10.1007/s10140-010-0869-8},
Key = {fds192791}
}
@article{fds192784,
Author = {AM Mohs and JM Provenzale},
Title = {Applications of nanotechnology to imaging and therapy of
brain tumors.},
Journal = {Neuroimaging clinics of North America},
Volume = {20},
Number = {3},
Pages = {283-92},
Year = {2010},
Month = {August},
ISSN = {1557-9867},
url = {http://dx.doi.org/10.1016/j.nic.2010.04.002},
Keywords = {Animals • Blood-Brain Barrier • Brain • Brain
Neoplasms • Drug Delivery Systems • Humans •
Magnetic Resonance Imaging • Nanoparticles •
Nanotechnology • Rats • diagnosis* • drug
effects • methods • methods* • pathology
• surgery • therapy*},
Abstract = {In the past decade, numerous advances in the understanding
of brain tumor physiology, tumor imaging, and tumor therapy
have been attained. In some cases, these advances have
resulted from refinements of pre-existing technologies (eg,
improvements of contrast-enhanced magnetic resonance
imaging). In other instances, advances have resulted from
development of novel technologies. The development of
nanomedicine (ie, applications of nanotechnology to the
field of medicine) is an example of the latter. In this
review, the authors explain the principles that underlay
nanoparticle design and function as well as the means by
which nanoparticles can be used for imaging and therapy of
brain tumors.},
Language = {eng},
Doi = {10.1016/j.nic.2010.04.002},
Key = {fds192784}
}
@article{fds192789,
Author = {JM Provenzale},
Title = {Proposal of a method for deciding whether an AJR manuscript
merits publication: The 25% rule.},
Journal = {AJR. American journal of roentgenology},
Volume = {195},
Number = {2},
Pages = {278-80},
Year = {2010},
Month = {August},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.10.4280},
Keywords = {Decision Support Techniques* • Peer Review, Research
• Periodicals as Topic* • Radiology* • United
States • methods*},
Abstract = {OBJECTIVE: The purpose of this article is to propose a rule
for determining which recommendation American Journal of
Roentgenology (AJR) reviewers should provide when performing
a review of a manuscript. CONCLUSION: The rule described
here should allow reviewers to better understand the
features that journal editors seek in a manuscript and to
determine which recommendation to provide for any specific
manuscript.},
Language = {eng},
Doi = {10.2214/AJR.10.4280},
Key = {fds192789}
}
@article{fds163835,
Author = {JJ Kim and WP Dillon and CM Glastonbury and JM Provenzale and M
Wintermark},
Title = {Sixty-four-section multidetector CT angiography of carotid
arteries: a systematic analysis of image quality and
artifacts.},
Journal = {AJNR. American journal of neuroradiology},
Volume = {31},
Number = {1},
Pages = {91-9},
Year = {2010},
Month = {January},
ISSN = {1936-959X},
url = {http://dx.doi.org/10.3174/ajnr.A1768},
Keywords = {Adult • Aged • Aged, 80 and over •
Angiography • Artifacts* • Carotid Arteries •
Female • Humans • Male • Middle Aged •
Retrospective Studies • Tomography, X-Ray Computed*
• Young Adult • methods •
radiography*},
Abstract = {OBJECTIVE: Sixty-four-section CT scanners have recently been
introduced for vascular imaging. Before such scanners reach
widespread use, scanning protocol should be optimized and
image quality assessed. The goals of this study were to
systematically measure image quality and determine the
prevalence of various types of artifacts produced by a
64-section scanner. METHODS: We retrospectively reviewed CT
angiography (CTA) scans obtained on a 64-section CT scanner
in 100 consecutive patients presenting to the emergency
department during a 2-month period with a suspected acute
cerebrovascular event. We evaluated scan quality by using 2
different methods: First, we quantitatively assessed
arterial opacification by measuring attenuation values in 9
arterial segments from the aortic arch to the distal
cervical internal carotid artery, by using a threshold of
150 HU as an indicator of good opacification. Second, we
assessed image contrast between arteries and veins by
measuring attenuation within venous segments and recording
the number of artery-vein-segment pairs in which the
attenuation difference was <or=50 HU. In addition, we
recorded the prevalence of the following artifacts: metallic
hardware streak, contrast material streak from slow-flowing
contrast material in adjacent large veins, streak artifacts
from shoulders, contrast material reflux into veins of the
neck, motion artifacts, and artifacts causing
misrepresentation of flow dynamics simulating arterial
dissection or occlusion. These results were compared with
those of a historical control group of 113 patients from our
institution who were imaged with the same technical
parameters on a 16-section CT scanner. RESULTS: The
quantitative assessment of arterial opacification showed
that 854 of 885 analyzed arterial segments (96.5%) had good
opacification (ie, attenuation values >150 HU). Image
contrast between artery and vein segments was also good,
with 714 of 763 analyzable segment pairs (85.6%) having >50
HU difference. Artifacts obscuring arterial evaluation
included streak from contrast material in the
subclavian/brachiocephalic vein (32% of patients),
attenuation of the x-ray beam between the shoulders (28%),
beam-hardening from metallic hardware (26%), and contrast
material reflux into neck veins (16%). The most clinically
relevant artifacts were flow artifacts, mimicking dissection
or vascular occlusion; they were seen in 14% of patients and
likely are related to the rapid data acquisition for CTA on
64-section scanners (compared with the circulation of
contrast material in the cervical arteries). None of the
patients in our historical control group who underwent
16-section CT had flow artifacts on their CTA studies; the
incidence of the other types of artifacts in this group was
similar to that in patients imaged with 64-section CT.
CONCLUSIONS: The 64-section CTA imaging protocol for carotid
arteries yields high-quality studies in >95% of
cases.},
Language = {eng},
Doi = {10.3174/ajnr.A1768},
Key = {fds163835}
}
@article{fds169375,
Author = {JM Provenzale and K van Landingham and LE White},
Title = {Clinical and imaging findings suggesting human herpesvirus 6
encephalitis.},
Journal = {Pediatric neurology, United States},
Volume = {42},
Number = {1},
Pages = {32-9},
Year = {2010},
Month = {January},
ISSN = {1873-5150},
Abstract = {We sought to distinguish patients testing positive for human
herpesvirus 6 from those testing negative, based on clinical
features and magnetic resonance images. Sixteen
immunosuppresed patients were tested by polymerase chain
reaction for human herpes virus 6 DNA in cerebrospinal fluid
(nine positive results). Medical records were examined for
agitation, altered mental status, hallucinations, insomnia,
memory loss, and seizures. Patients were sorted by viral
status. Clinical features were compared with imaging
findings. Insomnia, agitation, and hallucinations were
preferentially evident in human herpes virus 6-positive
patients. Imaging abnormalities were evident in the
hippocampus of both groups. However, extrahippocampal
involvement was more common in human herpes virus 6-positive
patients and among those with insomnia and hallucinations or
seizures. Patients with memory loss and imaging
abnormalities in the entorhinal cortex or amygdala were
likely to test positive, as were patients with
hallucinations and abnormal magnetic resonance signal in the
hippocampus. Human herpes virus 6 encephalitis patients
present with diverse clinical features that are also common
among patients who test negative. This entity should be
suspected in patients who present with insomnia, seizures,
or hallucinations when imaging abnormalities are evident in
the hippocampus, amygdala, and limbic structures beyond the
medial temporal lobe.},
Key = {fds169375}
}
@article{fds169376,
Author = {JM Provenzale},
Title = {Imaging of traumatic brain injury: a review of the recent
medical literature.},
Journal = {AJR. American journal of roentgenology, United
States},
Volume = {194},
Number = {1},
Pages = {16-9},
Year = {2010},
Month = {January},
ISSN = {1546-3141},
Abstract = {OBJECTIVE: This article provides a summary of some of the
important articles published during the period 2005-2009 on
the topic of imaging findings in head trauma. The intent is
to provide the latest information regarding the diagnosis of
important abnormalities and new insights into their clinical
significance. CONCLUSION: With the growing realization that
even mild head injury can lead to various types of
neurocognitive deficits, medical imaging of brain injury has
assumed even greater importance than previously.},
Key = {fds169376}
}
@article{fds169374,
Author = {JM Provenzale and C Ison and D Delong},
Title = {Bidimensional measurements in brain tumors: assessment of
interobserver variability.},
Journal = {AJR. American journal of roentgenology},
Volume = {193},
Number = {6},
Pages = {W515-22},
Year = {2009},
Month = {December},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.09.2615},
Keywords = {Brain Neoplasms • Disease Progression • Female
• Humans • Image Processing, Computer-Assisted
• Magnetic Resonance Imaging • Male • Middle
Aged • Reproducibility of Results • methods*
• pathology*},
Abstract = {OBJECTIVE: Bidimensional tumor measurements indicating a
greater than 25% increase in tumor size are generally
accepted as indicating tumor progression. We hypothesized
that use of digital images and a homogeneous reader
population would have lower interobserver variability than
in previous studies. METHODS: Eight board-certified
radiologists measured tumor diameters in three planes in two
consecutive MRI examinations of 22 patients with
contrast-enhancing high-grade brain tumors. Products of
tumor measurements were calculated, and determinations were
made about tumor progression (> 25% increase in area). A
variance components model was run on diameter products and
the ratios of consecutive maximal diameter products. The
variance components included patient examination effect,
reader effect, and residual effect. RESULTS: Complete
agreement was found among readers in 10 cases (45%), all
indicating stable disease. In the other 12 cases, at least
one reader considered progressive disease present. The
variance components model showed variance due to readers was
small, indicating only modest bias among readers. The
residual variance component was large (0.038), indicating
that repeated measurements on the same image likely are
variable even for the same reader. This variability in
measurement implies that repeated measurements by the
typical reader have an inherent 14% false-positive rate in
the diagnosis of progression of tumors that are stable.
CONCLUSIONS: Our hypothesis was disproved. We found
substantial interreader disagreement and indications that
the very nature of the measurement method produces a high
rate of false-positive readings of stable tumors. These
findings should be considered in interpretation of images
with this widely accepted criterion for brain tumor
progression.},
Language = {eng},
Doi = {10.2214/AJR.09.2615},
Key = {fds169374}
}
@article{fds163837,
Author = {JM Provenzale and L Hacein-Bey},
Title = {CT evaluation of subarachnoid hemorrhage: a practical review
for the radiologist interpreting emergency room
studies.},
Journal = {Emergency radiology},
Volume = {16},
Number = {6},
Pages = {441-51},
Year = {2009},
Month = {November},
ISSN = {1438-1435},
url = {http://dx.doi.org/10.1007/s10140-009-0824-8},
Keywords = {Aneurysm, Ruptured • Cerebral Angiography •
Contrast Media • Diagnosis, Differential •
Emergency Service, Hospital • False Positive Reactions
• Humans • Intracranial Aneurysm •
Sensitivity and Specificity • Subarachnoid Hemorrhage
• Tomography, X-Ray Computed • classification
• etiology • methods* • radiography*},
Abstract = {Radiologists working in an emergency radiology setting
frequently interpret computed tomography (CT) studies of
patients with suspected subarachnoid hemorrhage (SAH). This
article reviews the sensitivity of CT for detection of SAH,
some major patterns of SAH related to a ruptured aneurysm,
and the differential diagnosis of SAH not due to aneurysmal
rupture.},
Language = {eng},
Doi = {10.1007/s10140-009-0824-8},
Key = {fds163837}
}
@article{fds163836,
Author = {JM Provenzale and B Sarikaya},
Title = {Comparison of test performance characteristics of MRI, MR
angiography, and CT angiography in the diagnosis of carotid
and vertebral artery dissection: a review of the medical
literature.},
Journal = {AJR. American journal of roentgenology, United
States},
Volume = {193},
Number = {4},
Pages = {1167-74},
Year = {2009},
Month = {October},
ISSN = {1546-3141},
Abstract = {OBJECTIVE: Initial assessment of patients with suspected
dissection of the carotid or vertebral arteries typically is
made by MRI, alone or in combination with MR angiography
(MRA) or CT angiography (CTA). We reviewed the medical
literature to determine, based on test performance
characteristics such as sensitivity, specificity, positive
predictive value, and negative predictive value, whether
evidence could be found to support routine use of one
imaging technique over the other for assessment of suspected
dissection. CONCLUSION: Test characteristics for MR
techniques such as MRI and MRA were relatively similar to
those for CTA in diagnosis of carotid and vertebral artery
dissection.},
Key = {fds163836}
}
@article{fds163838,
Author = {JM Provenzale and GA Silva},
Title = {Uses of nanoparticles for central nervous system imaging and
therapy.},
Journal = {AJNR. American journal of neuroradiology},
Volume = {30},
Number = {7},
Pages = {1293-301},
Year = {2009},
Month = {August},
ISSN = {1936-959X},
url = {http://dx.doi.org/10.3174/ajnr.A1590},
Keywords = {Brain • Brain Diseases • Contrast Media •
Diagnostic Imaging • Drug Carriers • Image
Enhancement • Nanomedicine • Nanoparticles •
chemistry • chemistry* • diagnosis* •
diagnostic use* • methods • methods* •
pathology • radiography • therapeutic use* •
therapy* • trends*},
Abstract = {SUMMARY: Applications of nanotechnology to medicine are
leading to novel means of imaging living systems and of
delivering therapy. Much nanotechnology research is focused
on methods for imaging central nervous system functions and
disease states. In this review, the principles of
nanoparticle design and function are discussed with specific
emphasis on applications to neuroradiology. In addition to
innovative forms of imaging, this review describes
therapeutic uses of nanoparticles, such as drug delivery
systems, neuroprotection devices, and methods for tissue
regeneration.},
Language = {eng},
Doi = {10.3174/ajnr.A1590},
Key = {fds163838}
}
@article{fds158220,
Author = {JM Provenzale},
Title = {MRI and MRA for evaluation of dissection of craniocerebral
arteries: lessons from the medical literature.},
Journal = {Emergency radiology},
Volume = {16},
Number = {3},
Pages = {185-93},
Year = {2009},
Month = {May},
ISSN = {1438-1435},
url = {http://dx.doi.org/10.1007/s10140-008-0770-x},
Keywords = {Aneurysm, Dissecting • Carotid Artery Injuries •
Carotid Artery, Common • Cerebral Angiography •
Humans • Magnetic Resonance Angiography • Magnetic
Resonance Imaging* • Vertebral Artery • Vertebral
Artery Dissection • diagnosis* • radiography
• radiography*},
Abstract = {MR imaging and MR angiography have become first-line imaging
techniques in assessment of the patient with suspected
dissection of the carotid and vertebral arteries. This
review describes the advantages of these two techniques for
diagnosis and describes diagnostic pitfalls.},
Language = {eng},
Doi = {10.1007/s10140-008-0770-x},
Key = {fds158220}
}
@article{fds158211,
Author = {PK Duffner and M Caggana and JJ Orsini and DA Wenger and MC Patterson and CJ Crosley and J Kurtzberg and GL Arnold and ML Escolar and DJ Adams and MR
Andriola, AM Aron and E Ciafaloni and A Djukic and RW Erbe and P
Galvin-Parton, LE Helton and EH Kolodny and BE Kosofsky and DF Kronn and JM Kwon and PA Levy and J Miller-Horn and TP Naidich and JE Pellegrino and JM Provenzale and SJ Rothman and MP Wasserstein},
Title = {Newborn screening for krabbe disease: the new york state
model.},
Journal = {Pediatric neurology, United States},
Volume = {40},
Number = {4},
Pages = {245-52},
Year = {2009},
Month = {April},
ISSN = {0887-8994},
Abstract = {Krabbe disease is a rare inherited neurologic disorder
affecting the central and peripheral nervous systems. The
disease has four phenotypes: early infantile, later onset,
adolescent, and adult. The only known treatment is
hematopoietic stem cell transplantation, which is, in the
early infantile form of the disease, most beneficial if
performed before onset of clinical symptoms. In August 2006,
New York State began screening all newborns for Krabbe
disease. A rapid and accurate technique for assessing
galactocerebrosidase activity and performing DNA mutation
analysis had been developed. Interpreting these results was
limited, however, because neither enzyme activity nor
genetic mutation reliably predicts phenotype. A series of
initiatives were therefore developed by a multidisciplinary
group of neurologists, geneticists, metabolic pediatricians,
neurodevelopmental pediatricians, and transplant physicians
(the Krabbe Consortium of New York State) to enhance the
effectiveness of the newborn screening program. A
standardized clinical evaluation protocol was designed based
on the available literature, criteria for transplantation
for the early infantile phenotype were formulated, a
clinical database and registry was developed, and a study of
developmental and functional outcomes was instituted. This
multidisciplinary standardized approach to evaluating
infants who have positive results on newborn screening may
serve as a model for other states as they begin the process
of screening for Krabbe disease and other lysosomal storage
disorders.},
Key = {fds158211}
}
@article{fds158213,
Author = {MJ Crow and G Grant and JM Provenzale and A Wax},
Title = {Molecular imaging and quantitative measurement of epidermal
growth factor receptor expression in live cancer cells using
immunolabeled gold nanoparticles.},
Journal = {AJR. American journal of roentgenology},
Volume = {192},
Number = {4},
Pages = {1021-8},
Year = {2009},
Month = {April},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.07.3535},
Keywords = {Blotting, Western • Cell Line, Tumor • Gold •
Humans • Immunohistochemistry • Linear Models
• Microscopy • Microscopy, Fluorescence •
Molecular Probe Techniques • Nanoparticles •
Receptor, Epidermal Growth Factor • Spectrum Analysis
• diagnostic use* • metabolism* •
methods*},
Abstract = {OBJECTIVE: The goal of this study was to assess whether
immunolabeled nanoparticle biomarkers are comparable to
fluorescent marker imaging in measuring epidermal growth
factor receptor (EGFR) expression. METHODS: EGFR expression
was quantified using both imaging methods in four cell
lines: A431 human epidermoid carcinoma cells, which are
known to have high EGFR expression; two cell lines with
lower EGFR expression (270-GBM human glioblastoma xenograft
cells and H2224 human glioblastoma xenograft cells); and
MDA-MB-453 breast carcinoma cells, which do not express
EGFR. To enhance contrast of the nanoparticle biomarkers, a
darkfield microspectroscopy system was used that includes a
custom epi-illumination light train. RESULTS:
Nanoparticle-bound cells were clearly distinguished from
control cells not bound to nanoparticles in that they showed
a significant increase in detected intensity under darkfield
illumination due to nanoparticle scattering. The average
nanoparticle-scattering intensity for A431 cells was 41.5
counts per cell compared with 24.7 for 270-GBM cells, 8.77
for H2224 cells, and 0.44 for MDA-MB-453 cells. The average
fluorescence intensity for A431 cells was 35.3 counts per
cell compared with 28.7 for 270-GBM cells, 5.91 for H2224
cells, and 2.07 for MDA-MB-453 cells. A plot of fluorescence
intensity versus nanoparticle-scattering intensity for all
four cell lines showed that the data agree with a linear
relationship given by the following equation: NP = 1.0691 x
FL - 0.3873, where NP is the nanoparticle-scattering
intensity and FL is the fluorescence intensity. The
covariance of the data with the trend line was R(2) =
0.9409. The average peak wavelength of nanoparticle
scattering was 570.93 nm for A431 cells, 565.26 nm for
270-GBM cells, and 562.70 nm for H2224 cells (with no clear
peaks observed for MDA-MB-453 cells). This spectral trend
shows that nanoparticle scattering may reveal additional
information about their nanoenvironment via refractive index
sensitivity. CONCLUSIONS: Immunolabeled nanoparticles can
quantify receptor expression with performance comparable to
fluorescence markers and show promise to better characterize
receptor expression via their refractive index
sensitivity.},
Language = {eng},
Doi = {10.2214/AJR.07.3535},
Key = {fds158213}
}
@article{fds148369,
Author = {DJ Madden and J Spaniol and MC Costello and B Bucur and LE White and R
Cabeza, SW Davis and NA Dennis and JM Provenzale and SA
Huettel},
Title = {Cerebral white matter integrity mediates adult age
differences in cognitive performance.},
Journal = {Journal of cognitive neuroscience},
Volume = {21},
Number = {2},
Pages = {289-302},
Year = {2009},
Month = {February},
ISSN = {0898-929X},
url = {http://dx.doi.org/10.1162/jocn.2009.21047},
Keywords = {Adult • Age Factors • Aged • Aged, 80 and
over • Aging • Anisotropy • Brain •
Cognition • Corpus Callosum • Cues • Female
• Humans • Magnetic Resonance Imaging • Male
• Middle Aged • Neuropsychological Tests •
Psychomotor Performance • Reaction Time • Young
Adult • anatomy & histology • anatomy & histology*
• physiology • physiology*},
Abstract = {Previous research has established that age-related decline
occurs in measures of cerebral white matter integrity, but
the role of this decline in age-related cognitive changes is
not clear. To conclude that white matter integrity has a
mediating (causal) contribution, it is necessary to
demonstrate that statistical control of the white
matter-cognition relation reduces the magnitude of
age-cognition relation. In this research, we tested the
mediating role of white matter integrity, in the context of
a task-switching paradigm involving word categorization.
Participants were 20 healthy, community-dwelling older
adults (60-85 years), and 20 younger adults (18-27 years).
From diffusion tensor imaging tractography, we obtained
fractional anisotropy (FA) as an index of white matter
integrity in the genu and splenium of the corpus callosum
and the superior longitudinal fasciculus (SLF). Mean FA
values exhibited age-related decline consistent with a
decrease in white matter integrity. From a model of reaction
time distributions, we obtained independent estimates of the
decisional and nondecisional (perceptual-motor) components
of task performance. Age-related decline was evident in both
components. Critically, age differences in task performance
were mediated by FA in two regions: the central portion of
the genu, and splenium-parietal fibers in the right
hemisphere. This relation held only for the decisional
component and was not evident in the nondecisional
component. This result is the first demonstration that the
integrity of specific white matter tracts is a mediator of
age-related changes in cognitive performance.},
Language = {eng},
Doi = {10.1162/jocn.2009.21047},
Key = {fds148369}
}
@article{fds158214,
Author = {JM Provenzale},
Title = {Advances in pediatric neuroradiology: highlights of the
recent medical literature.},
Journal = {AJR. American journal of roentgenology},
Volume = {192},
Number = {1},
Pages = {19-25},
Year = {2009},
Month = {January},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.08.1889},
Keywords = {Brain Diseases • Child • Clinical Trials as Topic
• Forecasting* • Humans • Magnetic Resonance
Imaging • Nervous System Diseases •
Neuroradiography • Pediatrics • Periodicals as
Topic • Tomography, X-Ray Computed • diagnosis*
• trends • trends*},
Abstract = {OBJECTIVE: This review is an attempt to bring some of the
best articles in the recent pediatric neuroradiology
literature to the attention of the AJR readership.
CONCLUSION: Many advanced imaging capabilities are being
brought to bear to noninvasively monitor physiologic changes
in the abnormal pediatric brain. Furthermore, novel forms of
analysis that are evidence-based are being used to better
understand how imaging studies are used and the impact they
have on clinical decision making. The reader is encouraged
to read these articles in their entirety in order to better
understand the lines of inquiry contained in
them.},
Language = {eng},
Doi = {10.2214/AJR.08.1889},
Key = {fds158214}
}
@article{fds158218,
Author = {ER Heinz and JM Provenzale},
Title = {Imaging findings in neonatal hypoxia: a practical
review.},
Journal = {AJR. American journal of roentgenology},
Volume = {192},
Number = {1},
Pages = {41-7},
Year = {2009},
Month = {January},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.08.1321},
Keywords = {Brain • Female • Humans • Hypoxia, Brain
• Image Enhancement • Infant, Newborn •
Magnetic Resonance Imaging • Male • diagnosis*
• methods* • pathology*},
Abstract = {OBJECTIVE: The findings of hypoxia in the term neonate are
unique; neonatal brain imaging findings differ from those of
older children. Evaluation of neonatal brain images for
signs of hypoxic injury requires attention to a specific set
of signs. CONCLUSION: Imaging findings in term neonates must
be assessed according to different rules from those used in
other age groups. Four major signs are proposed as a means
of facilitating the diagnosis of hypoxia in the
neonate.},
Language = {eng},
Doi = {10.2214/AJR.08.1321},
Key = {fds158218}
}
@article{fds158219,
Author = {JM Provenzale and S Peddi and J Kurtzberg, MD Poe and S Mukundan and M
Escolar},
Title = {Correlation of neurodevelopmental features and MRI findings
in infantile Krabbe's disease.},
Journal = {AJR. American journal of roentgenology},
Volume = {192},
Number = {1},
Pages = {59-65},
Year = {2009},
Month = {January},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.07.3885},
Keywords = {Child Development* • Female • Humans • Infant
• Infant, Newborn • Leukodystrophy, Globoid Cell
• Magnetic Resonance Imaging • Male • Motor
Skills* • Neuropsychological Tests* •
Reproducibility of Results • Sensitivity and
Specificity • diagnosis* • methods*},
Abstract = {OBJECTIVE: The purpose of our study was to compare MRI
findings with neurobehavioral development in infants with
Krabbe's disease. METHODS: Nine infants with Krabbe's
disease underwent a total of 19 MR studies during the first
year of life as well as tests of mental development, gross
motor skills, and fine motor skills (score range: 0-100)
within 1 month of imaging. MR scans were scored using the
Loes severity scale based on signal abnormality and atrophy,
ranging from 0 (best) to 32. We performed three comparisons
(Student's t test): each test versus total brain Loes score,
fine motor and gross motor tests versus Loes score for the
pyramidal tract, and fine motor and gross motor tests versus
Loes score for the internal capsule. RESULTS: Mean test
results were 65+/-31 for mental development, 48+/-39 for
gross motor score, 57+/-35 for fine motor score, and mean
total brain score was 7.79+/-6.20. Correlations for total
Loes score were -0.78 (p=0.003) for mental development,
-0.74 (p=0.003) for gross motor function, and -0.80
(p<0.001) for fine motor function. Correlations for
pyramidal system Loes scores were -0.73 (p=0.003) for fine
motor function and -0.58 (p=0.028) for gross motor function.
Correlation between Loes scores for internal capsule and
fine motor function was -0.38 (p>0.05) and between Loes
scores for internal capsule and gross motor function was
-0.35 (p>0.05). CONCLUSIONS: The very good correlation
between testing results and Loes scores for the entire brain
and moderately good correlation between test results and
scores for specific brain regions indicate the Loes scoring
system likely provides a reasonable means for assessing
prognosis and therapeutic response for infants with Krabbe's
disease.},
Language = {eng},
Doi = {10.2214/AJR.07.3885},
Key = {fds158219}
}
@article{fds158215,
Author = {JM Provenzale and KE vanLandingham, DV Lewis and S Mukundan and LE
White},
Title = {Extrahippocampal involvement in human herpesvirus 6
encephalitis depicted at MR imaging.},
Journal = {Radiology, United States},
Volume = {249},
Number = {3},
Pages = {955-63},
Year = {2008},
Month = {December},
ISSN = {1527-1315},
Abstract = {PURPOSE: To test the hypothesis that patterns of signal
intensity abnormality in human herpesvirus 6 (HHV6)-positive
patients would allow distinction from patients who did not
test positive for HHV6 encephalitis. MATERIALS AND METHODS:
This retrospective study was performed with institutional
review board committee approval by using a waiver of
informed consent. Sixteen immunocompromised patients (nine
males, seven females; age range, 2-39 years) underwent
magnetic resonance (MR) imaging and cerebrospinal fluid
polymerase chain reaction (PCR) testing for HHV6 DNA on the
basis of clinical findings suspicious for encephalitis. MR
images acquired during acute illness were examined without
knowing PCR results. RESULTS: Nine patients were HHV6
positive. Seven showed signal intensity abnormalities, with
prominent involvement of the hippocampus, and six showed
additional involvement of the amygdala. Three HHV6-positive
patients showed signal intensity abnormality in
extrahippocampal divisions of the olfactory cortex and
cortical and subcortical structures that maintain prominent
connections with the hippocampal formation. Among the seven
HHV6-negative patients, six had abnormalities in the
hippocampus but only two showed extrahippocampal
involvement, which was restricted to the amygdala.
CONCLUSION: Most patients with HHV6 encephalitis have signal
intensity abnormalities in the hippocampal formation and
amygdala and, contrary to prior reports, some also have
involvement of limbic structures outside of the medial
temporal lobe. The presence of MR signal intensity
abnormality in the medial temporal lobe should raise the
diagnosis of HHV6 encephalitis in immunosuppressed patients,
especially when hyperintense lesions are seen in the insular
region and inferior frontal lobe.},
Key = {fds158215}
}
@article{fds158216,
Author = {JM Provenzale},
Title = {Nephrogenic systemic fibrosis: some considerations on the
debate regarding its cause.},
Journal = {AJR. American journal of roentgenology},
Volume = {191},
Number = {6},
Pages = {1867-9},
Year = {2008},
Month = {December},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.08.1541},
Keywords = {Contrast Media • Gadolinium • Humans •
Magnetic Resonance Imaging • Nephrogenic Fibrosing
Dermopathy • diagnosis* • diagnostic use* •
metabolism* • methods* • pharmacokinetics*},
Language = {eng},
Doi = {10.2214/AJR.08.1541},
Key = {fds158216}
}
@article{fds158217,
Author = {RJ Viola and JM Provenzale and F Li and CY Li and H Yuan and J Tashjian and MW
Dewhirst},
Title = {In vivo bioluminescence imaging monitoring of
hypoxia-inducible factor 1alpha, a promoter that protects
cells, in response to chemotherapy.},
Journal = {AJR. American journal of roentgenology},
Volume = {191},
Number = {6},
Pages = {1779-84},
Year = {2008},
Month = {December},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.07.4060},
Keywords = {Animals • Antineoplastic Agents • Breast Neoplasms
• Cell Line, Tumor • Cyclophosphamide •
Hypoxia-Inducible Factor 1 • Luminescent Measurements
• Luminescent Proteins • Mice • Mice, Inbred
BALB C • Paclitaxel • Promoter Regions, Genetic
• administration & dosage • administration &
dosage* • drug therapy* • genetics •
metabolism* • methods*},
Abstract = {OBJECTIVE: Bioluminescence imaging is a powerful technique
that has shown that hypoxia-inducible factor 1 (HIF-1), a
transcription factor that protects tumor cells from hypoxia,
is up-regulated in tumors after radiation therapy. We tested
the hypothesis that bioluminescence imaging would
successfully and noninvasively depict an increase in HIF-1
in the novel therapeutic environment of chemotherapy and
that, as in radiation therapy, the underlying mechanism
involves inducible nitric oxide synthase originating in
macrophages. Active HIF-1 consists of alpha and beta
subunits that bind to promoter sequences in many genes,
including those that protect endothelial cells, promote
angiogenesis, and alter metastasis and tumor cell
metabolism. METHODS: We grew 4T1 murine breast carcinoma
cells with an HIF-1alpha luciferase reporter construct to 7
mm in the right rear flanks of 18 Balb-C mice. The mice were
evenly randomized to receive one of the following single
intraperitoneal doses: maximum tolerated dose
cyclophosphamide (231.5 mg/kg), maximum tolerated dose
paclitaxel (10 mg/kg), or control saline solution.
Immunohistochemical analysis of tumor sections from the
cyclophosphamide and control groups was performed 10 days
after treatment to assess the intensity and distribution of
HIF-1alpha expression, hypoxia, macrophage infiltration, and
expression of macrophage-derived inducible nitric oxide
synthase in tumor tissues treated with maximum tolerated
dose cyclophosphamide compared with control tumors. RESULTS:
Cyclophosphamide, but not paclitaxel, significantly
inhibited tumor growth and caused a significant increase in
HIF-1alpha protein levels, which peaked at a 10-fold
increase from baseline on day 10 after administration. In
contrast, paclitaxel did not have an antitumor effect in
this model and did not cause a significant increase in
HIF-1alpha. Immunohistochemical analysis showed increased
and more evenly dispersed levels of HIF-1alpha protein,
macrophage infiltration, and expression of inducible nitric
oxide synthase originating in macrophages after
cyclophosphamide treatment. CONCLUSIONS: We successfully
monitored increased expression of a tumor protective protein
in a noninvasive manner. Such monitoring may be a means of
detection of resistance to therapy, and it may be possible
to use the monitoring findings to alter treatment strategies
in real time. The tumor microenvironment seen at
immunohistochemical analysis supports the hypothesized
mechanism that the cytotoxic effects of radiation therapy
that attract macrophages, causing the release of
macrophage-derived inducible nitric oxide synthase and
production of HIF-1alpha under aerobic conditions, also
underlie chemotherapy. Such noninvasive imaging may be a
means to development of therapeutic strategies that prevent
HIF-1 up-regulation after chemotherapy treatments.},
Language = {eng},
Doi = {10.2214/AJR.07.4060},
Key = {fds158217}
}
@article{fds158212,
Author = {JM Provenzale and M Wintermark},
Title = {Optimization of perfusion imaging for acute cerebral
ischemia: review of recent clinical trials and
recommendations for future studies.},
Journal = {AJR. American journal of roentgenology},
Volume = {191},
Number = {4},
Pages = {1263-70},
Year = {2008},
Month = {October},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.07.3575},
Keywords = {Acute Disease • Brain Ischemia • Clinical Trials
as Topic • Humans • Magnetic Resonance Imaging
• Tomography, X-Ray Computed • diagnosis* •
methods* • radiography},
Abstract = {OBJECTIVE: The use of thrombolytic agents and other forms of
reperfusion therapy has provided a means to reverse ischemia
and minimize the size of infarctions. The purpose of this
review is to examine various clinical trials of reperfusion
agents and address key imaging issues. CONCLUSION: Advanced
MRI and CT play a growing role in selection of patients for
therapy. Numerous clinical trials have shed light on the
efficacy of various reperfusion therapies; disparities in
trial design have also left unanswered questions.},
Language = {eng},
Doi = {10.2214/AJR.07.3575},
Key = {fds158212}
}
@article{fds148366,
Author = {JM Provenzale and K Shah and U Patel and DC McCrory},
Title = {Systematic Review of CT and MR Perfusion Imaging for
Assessment of Acute Cerebrovascular Disease.},
Journal = {AJNR. American journal of neuroradiology},
Year = {2008},
Month = {June},
ISSN = {1936-959X},
Abstract = {BACKGROUND AND PURPOSE: Perfusion imaging sequences are an
important part of imaging studies designed to provide
information to guide therapy for treatment of
cerebrovascular disease. The purpose of this study was to
perform a meta-analysis of the medical literature on
perfusion imaging to determine its role in clinical decision
making for patients with acute cerebral ischemia. MATERIALS
AND METHODS: We searched MEDLINE by using a strategy that
combined terms related to perfusion imaging with terms
related to acute cerebral ischemia and brain tumors. We
identified 658 perfusion imaging articles and classified
them according to the clinical usefulness criteria of
Thornbury and Fryback. We found 59 articles with promise of
indicating usefulness in clinical decision making. We
devised and implemented a clinical decision making scoring
scale more appropriate to the topic of acute cerebral
ischemia. RESULTS: Several articles provided important
insights into the physiologic processes underlying acute
cerebral ischemia by correlation of initial perfusion
imaging deficits with clinical outcome or ultimate size of
the infarct. However, most articles showed relatively low
relevance to influencing decisions in implementing
treatment. CONCLUSION: Most perfusion imaging articles are
oriented toward important topics such as optimization of
imaging parameters, determination of ischemia penumbra, and
prediction of outcome. However, information as to the role
of perfusion imaging in clinical decision making is lacking.
Studies are needed to demonstrate that use of perfusion
imaging changes outcome of patients with acute cerebral
ischemia.},
Key = {fds148366}
}
@article{fds148373,
Author = {JH Sampson and G Akabani and GE Archer and MS Berger and RE Coleman and AH
Friedman, HS Friedman and K Greer and JE Herndon 2nd and S Kunwar and RE
McLendon, A Paolino and NA Petry and JM Provenzale and DA Reardon and TZ
Wong, MR Zalutsky and I Pastan and DD Bigner},
Title = {Intracerebral infusion of an EGFR-targeted toxin in
recurrent malignant brain tumors.},
Journal = {Neuro-oncology},
Volume = {10},
Number = {3},
Pages = {320-9},
Year = {2008},
Month = {June},
ISSN = {1522-8517},
url = {http://dx.doi.org/10.1215/15228517-2008-012},
Keywords = {Adult • Aged • Antineoplastic Agents • Brain
Neoplasms • Exotoxins • Humans • Immunotoxins
• Injections, Intraventricular • Magnetic
Resonance Imaging • Maximum Tolerated Dose •
Middle Aged • Neoplasm Recurrence, Local •
Receptor, Epidermal Growth Factor • Tomography,
Emission-Computed, Single-Photon • Transforming Growth
Factor alpha • administration & dosage* • adverse
effects • antagonists & inhibitors* • drug
therapy*},
Abstract = {The purpose of this study is to determine the maximum
tolerated dose (MTD), dose-limiting toxicity (DLT), and
intracerebral distribution of a recombinant toxin (TP-38)
targeting the epidermal growth factor receptor in patients
with recurrent malignant brain tumors using the
intracerebral infusion technique of convection-enhanced
delivery (CED). Twenty patients were enrolled and stratified
for dose escalation by the presence of residual tumor from
25 to 100 ng/ml in a 40-ml infusion volume. In the last
eight patients, coinfusion of (123)I-albumin was performed
to monitor distribution within the brain. The MTD was not
reached in this study. Dose escalation was stopped at 100
ng/ml due to inconsistent drug delivery as evidenced by
imaging the coinfused (123)I-albumin. Two DLTs were seen,
and both were neurologic. Median survival after TP-38 was 28
weeks (95% confidence interval, 26.5-102.8). Of 15 patients
treated with residual disease, two (13.3%) demonstrated
radiographic responses, including one patient with
glioblastoma multiforme who had a nearly complete response
and remains alive >260 weeks after therapy. Coinfusion of
(123)I-albumin demonstrated that high concentrations of the
infusate could be delivered >4 cm from the catheter tip.
However, only 3 of 16 (19%) catheters produced
intraparenchymal infusate distribution, while the majority
leaked infusate into the cerebrospinal fluid spaces.
Intracerebral CED of TP-38 was well tolerated and produced
some durable radiographic responses at doses <or=100 ng/ml.
CED has significant potential for enhancing delivery of
therapeutic macromolecules throughout the human brain.
However, the potential efficacy of drugs delivered by this
technique may be severely constrained by ineffective
infusion in many patients.},
Language = {eng},
Doi = {10.1215/15228517-2008-012},
Key = {fds148373}
}
@article{fds148364,
Author = {JM Provenzale and DP Barboriak and K VanLandingham and J MacFall and D
Delong, DV Lewis},
Title = {Hippocampal MRI signal hyperintensity after febrile status
epilepticus is predictive of subsequent mesial temporal
sclerosis.},
Journal = {AJR. American journal of roentgenology, United
States},
Volume = {190},
Number = {4},
Pages = {976-83},
Year = {2008},
Month = {April},
ISSN = {1546-3141},
Keywords = {Child • Child, Preschool • Epilepsy, Temporal Lobe
• Female • Hippocampus • Humans • Infant
• Linear Models • Magnetic Resonance Imaging
• Male • Prospective Studies • Sclerosis
• Seizures, Febrile • Status Epilepticus •
complications • etiology • methods* •
pathology • pathology*},
Abstract = {OBJECTIVE: The objective of our study was to test the
hypothesis that the finding of hyperintense hippocampal
signal intensity on T2-weighted MR images soon after febrile
status epilepticus is associated with subsequent hippocampal
volume loss and persistent abnormal signal intensity on
T2-weighted images (i.e., mesial temporal sclerosis).
SUBJECTS AND METHODS: Eleven children (mean age, 25 months)
underwent initial MRI that included coronal temporal lobe
imaging within 72 hours of febrile status epilepticus and
follow-up imaging from 3 to 23 months later (mean, 9
months). A neuroradiologist blinded to clinical history
graded initial and follow-up hippocampal signal intensity on
a scale from 0 (normal) to 4 (markedly increased). Two
blinded observers measured hippocampal volumes on initial
and follow-up MR studies using commercially available
software and volumes from 30 healthy children (mean age, 6.3
years). Initial signal intensity and hippocampal volume
changes were compared using Kendall tau correlation
coefficients. RESULTS: On initial imaging, hyperintense
signal intensity ranging from 1 (minimally increased) to 4
(markedly increased) was seen in seven children. Four
children had at least one hippocampus with moderate or
marked signal abnormality, three children had a hippocampus
with mild or minimal abnormality, and four children had
normal signal intensity. The Kendall tau correlation
coefficient between signal intensity increase and volume
change was -0.68 (p < 0.01). Five children (two with
temporal lobe epilepsy and two with complex partial
seizures) had hippocampal volume loss and increased signal
intensity on follow-up imaging, meeting the criteria for
mesial temporal sclerosis. CONCLUSION: MRI findings of a
markedly hyperintense hippocampus in children with febrile
status epilepticus was highly associated with subsequent
mesial temporal sclerosis.},
Key = {fds148364}
}
@article{fds148376,
Author = {LP Golding and JM Provenzale},
Title = {Nephrogenic systemic fibrosis: possible association with a
predisposing infection.},
Journal = {AJR. American journal of roentgenology},
Volume = {190},
Number = {4},
Pages = {1069-75},
Year = {2008},
Month = {April},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.07.2884},
Keywords = {Aged • Biopsy • Contrast Media • Female
• Fibrosis • Gadolinium DTPA • Humans •
Infection • Magnetic Resonance Imaging* • Male
• Prospective Studies • Renal Insufficiency •
Risk Factors • Skin Diseases • adverse effects*
• chemically induced • chemically induced* •
complications*},
Abstract = {OBJECTIVE: Infection at time of MR contrast administration
has been reported to predispose patients with renal failure
to development of nephrogenic systemic fibrosis (NSF). We
assessed the frequency of infection at the time of MR
contrast administration in a group of NSF patients. METHODS:
Eight patients developed NSF during 2002-2006, of whom seven
received the MR contrast agent gadodiamide (Omniscan), with
doses of 0.10-0.31 mmol/kg. Data for the following were
available for only 2005 and 2006: numbers of infected and
uninfected renal failure patients who received MR contrast
material and number of contrast-enhanced MR scans in all
patients. We extrapolated data to 2002-2006 to approximate
rates of NSF in infected and uninfected renal failure
patients using Fisher's exact test for association between
variables and calculated odds ratios with 95% CIs. RESULTS:
Five of seven NSF patients receiving MR contrast material
had infections at the time of contrast administration. Three
hundred thirty-four patients with renal failure received MR
contrast material in 2005 and 2006 (29 infected). The rate
of NSF was 6.7% in infected renal failure patients and 0.26%
in uninfected patients. Data extrapolated to 2002-2006
yielded estimates of 75 infected and 750 uninfected renal
failure patients. The association of NSF with infection was
highly significant (p < 0.001) with an odds ratio of 25 and
CI of 3.9-264.4. CONCLUSIONS: The association of NSF with
infection was highly significant, supporting the hypothesis
that infection at the time of MR contrast administration in
renal failure patients predisposes to NSF.},
Language = {eng},
Doi = {10.2214/AJR.07.2884},
Key = {fds148376}
}
@article{fds132221,
Author = {DL Greenberg and DF Messer and ME Payne, JR Macfall and JM
Provenzale, DC Steffens and RR Krishnan},
Title = {Aging, gender, and the elderly adult brain: an examination
of analytical strategies.},
Journal = {Neurobiology of aging},
Volume = {29},
Number = {2},
Pages = {290-302},
Year = {2008},
Month = {February},
ISSN = {1558-1497},
url = {http://dx.doi.org/10.1016/j.neurobiolaging.2006.09.016},
Keywords = {Aged • Aged, 80 and over • Aging* • Brain
• Female • Functional Laterality • Humans
• Magnetic Resonance Imaging • Male • Middle
Aged • Reproducibility of Results • Sex
Characteristics* • anatomy & histology*},
Abstract = {We sought to examine the relations between age, gender and
brain volumes in an elderly population; we also sought to
examine ways of measuring these relations. Three sets of
analyses were used: correlational analyses, in which
correlations between independent variables and brain volumes
were calculated without correction for intracranial volume
(ICV); covariational analyses, in which ICV was used as a
covariate in regression equations; and ratio analyses, in
which the dependent variable was the ratio of brain volume
to ICV. These analyses yielded similar results, except that
(as expected) adjusting for ICV altered estimates of gender
differences. Analyses of age showed decreases in left
caudate, putamen, and right hippocampus and an increase in
CSF, a result generally in accord with previous findings.
However, we also found a significant decrease of
white-matter volumes and no significant decrease in total
gray-matter volumes. Correlational analyses showed that men
did not always have larger volumes despite their larger head
size; women generally had larger volumes after adjusting for
ICV. We found no age-gender interactions.},
Language = {eng},
Doi = {10.1016/j.neurobiolaging.2006.09.016},
Key = {fds132221}
}
@article{fds148370,
Author = {WD Taylor, JR Macfall and ME Payne and DR McQuoid and DC Steffens and JM
Provenzale, KR Krishnan},
Title = {Orbitofrontal cortex volume in late life depression:
influence of hyperintense lesions and genetic
polymorphisms.},
Journal = {Psychological medicine, England},
Volume = {37},
Number = {12},
Pages = {1763-73},
Year = {2007},
Month = {December},
ISSN = {0033-2917},
Keywords = {Aged • Aged, 80 and over • Apolipoprotein E4
• Atrophy • Brain • Cross-Sectional Studies
• Depressive Disorder, Major • Female •
Frontal Lobe • Genotype* • Humans • Image
Processing, Computer-Assisted* • Magnetic Resonance
Imaging* • Male • Mental Status Schedule •
Middle Aged • Nerve Fibers, Myelinated • Nerve Net
• Organ Size • Risk Factors • Serotonin
Plasma Membrane Transport Proteins • diagnosis* •
genetics* • pathology • pathology*},
Abstract = {BACKGROUND: Orbitofrontal cortex (OFC) volumetric
differences have been reported in depression, but in
relatively small samples. Factors associated with these
differences are not well described. We examined OFC volumes
in a large sample of elderly depressed and non-depressed
subjects, exploring the relationship between OFC volume,
5HTTLPR genotype, apolipoprotein E (APOE) genotype and
hyperintense lesion volume. We hypothesized that smaller OFC
volume would be associated with depression, greater
hyperintense lesion volume and severity, and APOE epsilon4
or 5HTTLPR short allele carriers. METHOD: A total of 226
depressed and 144 non-depressed older subjects completed 1.5
T magnetic resonance imaging (MRI) and genotyping. OFC
volumes and lesion volumes were measured using standardized
methods. Lesion severity was additionally rated using the
Coffey rating scale. Differences between groups were
compared while controlling for age, sex and total cerebral
volume; separate models added lesion measures and genetic
polymorphisms. RESULTS: Depressed subjects exhibited smaller
OFC volumes. There was a trend for a negative association
between white-matter lesion volume and OFC volume; however,
rated white-matter lesion severity was significantly
negatively associated with OFC volume. There was no
association between gray-matter lesion measures or 5HTTLPR
genotype and OFC volume. Contrary to our hypothesis,
subjects who were APOE epsilon4 allele positive exhibited
larger OFC volumes; in secondary analyses, this finding was
limited to the non-depressed group. CONCLUSIONS: Reduced OFC
volumes are seen in depression and associated with greater
severity of white-matter lesions. Healthy subjects who are
APOE epsilon4 allele positive exhibited larger OFC volumes.
This finding should be examined in other
populations.},
Key = {fds148370}
}
@article{fds148371,
Author = {A Mamourian and R Bird and PW Schaefer and SW Atlas and WP Dillon and JM
Provenzale, CL Truwit and DW Chakeres},
Title = {Aneurysm clip.},
Journal = {Journal of neurosurgery},
Volume = {107},
Number = {6},
Pages = {1278-9},
Year = {2007},
Month = {December},
ISSN = {0022-3085},
url = {http://dx.doi.org/10.3171/JNS-07/12/1278},
Keywords = {Aneurysm • Documentation* • Humans • Magnetic
Resonance Imaging • Postoperative Period •
Surgical Instruments • adverse effects* •
classification* • diagnosis* • methods •
surgery*},
Language = {eng},
Doi = {10.3171/JNS-07/12/1278},
Key = {fds148371}
}
@article{fds148363,
Author = {JM Provenzale and L Liang and D DeLong and LE White},
Title = {Diffusion tensor imaging assessment of brain white matter
maturation during the first postnatal year.},
Journal = {AJR. American journal of roentgenology},
Volume = {189},
Number = {2},
Pages = {476-86},
Year = {2007},
Month = {August},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.07.2132},
Keywords = {Anisotropy • Brain • Brain Mapping •
Diffusion Magnetic Resonance Imaging • Female •
Humans • Infant • Infant, Newborn • Infant,
Premature • Linear Models • Male • Reference
Values • growth & development* •
methods*},
Abstract = {OBJECTIVE: The purpose of this study was to use
diffusion-weighted and diffusion tensor imaging to
investigate the status of cerebral white matter (WM) at term
gestation and the rate of WM maturation throughout the first
year of life in healthy infants. METHODS: Fifty-three
children (35 boys) ranging in age from 1.5 weeks premature
to 51.5 weeks (mean age, 22.9 weeks) underwent conventional
MRI, diffusion imaging in three directions (b = 1,000
s/mm2), and diffusion tensor imaging with gradient encoding
in six directions, all on a 1.5-T MRI system. Apparent
diffusion coefficient (ADC) and fractional anisotropy (FA)
were measured in three deep WM structures (posterior limb of
internal capsule, genu, and splenium of corpus callosum) and
two peripheral WM regions (associational WM underlying
prefrontal and posterior parietal cortex) with a standard
region of interest (44 +/- 4 cm2). ADC and FA were expressed
as a percentage of corresponding values measured in a group
of healthy young adults. Mean ADC and FA values for deep and
peripheral WM were plotted against gestational age
normalized to term. The data were fit best with a
broken-line linear regression model with a breakpoint at 100
days. ADC and FA values at term were estimated according to
the intercept of the initial linear period (before day 100)
with day 0. The slope of the linear fits was used to
determine the rate of WM maturation in both the early and
the late (after day 100) periods. Multivariate analysis of
variance tests were used to compare deep and peripheral WM
structures at term and at representative early and late ages
(days 30 and 200) and to compare rates of ADC and FA
maturation in early and late periods within the first year.
RESULTS: At term, peripheral WM was less mature than deep WM
according to results of extrapolation of ADC and FA values
in the first 100 days of life to day 0 (p < 0.01). Mean ADC
and FA value (percentage of mean adult value) for peripheral
WM were 1.32 x 10(-3) mm2/s (163%) and 0.16 (32%),
respectively, and 1.09 x 10(-3) mm2/s (143%) and 0.36 (54%),
respectively, for deep WM. On day 30 and day 200, estimated
mean ADC and FA continued to show greater diffusion (higher
ADC) and less anisotropy (lower FA value) in peripheral WM
(p <0.01). During the first year of postnatal life, both ADC
and FA matured at higher rates before postnatal day 100
compared with a later time. Differences were observed in
rates of maturation in the first 100 days when rates of
decrease in ADC and increase in FA were compared between
peripheral WM and deep WM; however, the maturational trends
differed whether ADC or FA was examined. The early rate of
ADC decrease (maturation) was twice as great for peripheral
WM than for deep WM (p < 0.01) unexpectedly, but the
opposite pattern was observed for FA. The early rate of FA
increase (maturation) was approximately one half as great
for peripheral WM as for deep WM (p = 0.01). Throughout the
rest of the first year, no differences were observed in the
rates of change in either index between peripheral WM and
deep WM. CONCLUSIONS: At term, both ADC and FA differ
significantly in peripheral WM and deep WM, deep WM
structures being more mature. Both deep WM and peripheral WM
mature more rapidly during approximately the first 3 months
in comparison with the rest of the first year. Unexpected
differences in early (first 100 days) rates of maturation
assessed with diffusion-weighted (ADC) and diffusion tensor
(FA) imaging suggest that these two techniques may be
sensitive to different aspects of WM maturation in the early
perinatal period.},
Language = {eng},
Doi = {10.2214/AJR.07.2132},
Key = {fds148363}
}
@article{fds148375,
Author = {JH Sampson and R Raghavan and ML Brady and JM Provenzale and JE Herndon and D Croteau and AH Friedman and DA Reardon and RE Coleman and T Wong and DD
Bigner, I Pastan and MI Rodríguez-Ponce and P Tanner and R Puri and C
Pedain},
Title = {Clinical utility of a patient-specific algorithm for
simulating intracerebral drug infusions.},
Journal = {Neuro-oncology, United States},
Volume = {9},
Number = {3},
Pages = {343-53},
Year = {2007},
Month = {July},
ISSN = {1522-8517},
Keywords = {Adult • Algorithms* • Antineoplastic Agents •
Brain Neoplasms • Diagnostic Imaging* • Drug
Delivery Systems • Exotoxins • Female •
Glioma • Humans • Injections, Intraventricular
• Interleukin-13 • Male • Middle Aged •
Neoplasm Recurrence, Local • Pilot Projects •
Sensitivity and Specificity • Software* •
administration & dosage • administration & dosage*
• drug therapy • drug therapy*},
Abstract = {Convection-enhanced delivery (CED) is a novel drug delivery
technique that uses positive infusion pressure to deliver
therapeutic agents directly into the interstitial spaces of
the brain. Despite the promise of CED, clinical trials have
demonstrated that target-tissue anatomy and patient-specific
physiology play a major role in drug distribution using this
technique. In this study, we retrospectively tested the
ability of a software algorithm using MR diffusion tensor
imaging to predict patient-specific drug distributions by
CED. A tumor-targeted cytotoxin, cintredekin besudotox
(interleukin 13-PE38QQR), was coinfused with iodine
123-labeled human serum albumin (123I-HSA), in patients with
recurrent malignant gliomas. The spatial distribution of
123I-HSA was then compared to a drug distribution simulation
provided by the software algorithm. The algorithm had a high
sensitivity (71.4%) and specificity (100%) for identifying
the high proportion (7 of 14) of catheter trajectories that
failed to deliver drug into the desired anatomical region (p
= 0.021). This usually occurred when catheter trajectories
crossed deep sulci, resulting in leak of the infusate into
the subarachnoid cerebrospinal fluid space. The mean
concordance of the volume of distribution at the 50% isodose
level between the actual 123I-HSA distribution and
simulation was 65.75% (95% confidence interval [CI],
52.0%-79.5%), and the mean maximal inplane deviation was
less than 8.5 mm (95% CI, 4.0-13.0 mm). The use of this
simulation algorithm was considered clinically useful in
84.6% of catheters. Routine use of this algorithm, and its
further developments, should improve prospective selection
of catheter trajectories, and thereby improve the efficacy
of drugs delivered by this promising technique.},
Key = {fds148375}
}
@article{fds148360,
Author = {WD Taylor and JN Bae, JR MacFall and ME Payne and JM Provenzale and DC
Steffens, KR Krishnan},
Title = {Widespread effects of hyperintense lesions on cerebral white
matter structure.},
Journal = {AJR. American journal of roentgenology},
Volume = {188},
Number = {6},
Pages = {1695-704},
Year = {2007},
Month = {June},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.06.1163},
Keywords = {Aged • Aged, 80 and over • Brain • Brain
Diseases • Demyelinating Diseases • Diffusion
Magnetic Resonance Imaging • Female • Humans
• Male • Middle Aged • Nerve Fibers,
Myelinated • diagnosis* • methods* •
pathology*},
Abstract = {OBJECTIVE: Hyperintense lesions are a common finding on
neuroimaging and are associated not only with aging, medical
illness, and some invasive medical procedures, but also with
neurologic and psychiatric morbidity. We hypothesized that
hyperintense lesions are associated with alterations in
white matter structure beyond the visible lesion boundaries
as assessed with diffusion tensor imaging (DTI). METHODS:
Eighty-two neurologically intact older individuals completed
brain MRI with DTI. DTI scans were analyzed using regions of
interest placed in normal-appearing white matter to measure
fractional anisotropy and diffusivity in the white matter of
the frontal lobe, the genu of the corpus callosum, and the
internal capsule. Hyperintense lesions volumes were measured
separately in subcortical gray matter and anterior white
matter through a semiautomated segmentation program. The
relationship between lesion volumes and DTI measures was
examined while controlling for patient age, patient sex, and
total cerebral volume. RESULTS: Greater anterior white
matter lesion volumes were associated with higher
diffusivity and lower anisotropy in the white matter of the
dorsolateral prefrontal cortex and with higher diffusivity
of the internal capsule and white matter lateral to the
anterior cingulate cortex. Gray matter lesion volumes were
associated with higher diffusivity in the genu of the corpus
callosum and the internal capsule. CONCLUSIONS: Ischemic
hyperintense lesions are associated with widespread effects
on the structure of the frontal lobe white matter and
central white matter structures. This may reflect effects of
lesions on neural circuits or identification of white matter
changes that have not yet become visible on conventional
MRI.},
Language = {eng},
Doi = {10.2214/AJR.06.1163},
Key = {fds148360}
}
@article{fds148374,
Author = {D Beam, MD Poe and JM Provenzale and P Szabolcs and PL Martin and V
Prasad, S Parikh and T Driscoll and S Mukundan and J Kurtzberg and ML
Escolar},
Title = {Outcomes of unrelated umbilical cord blood transplantation
for X-linked adrenoleukodystrophy.},
Journal = {Biology of blood and marrow transplantation : journal of the
American Society for Blood and Marrow Transplantation},
Volume = {13},
Number = {6},
Pages = {665-74},
Year = {2007},
Month = {June},
ISSN = {1083-8791},
url = {http://dx.doi.org/10.1016/j.bbmt.2007.01.082},
Keywords = {Adrenoleukodystrophy • Child • Child, Preschool
• Cognition • Cord Blood Stem Cell Transplantation
• Graft Survival • Graft vs Host Disease •
Histocompatibility Testing • Humans • Language
Development • Male • Motor Activity •
Myeloablative Agonists • Neurophysiology •
Predictive Value of Tests • Survival Rate •
Transplantation Conditioning • Treatment Outcome •
complications • methods • methods* •
mortality • physiopathology • therapeutic use
• therapy*},
Abstract = {Adrenoleukodystrophy (ALD) is an X-linked disorder caused by
a defect in the metabolism of long chain fatty acids leading
to demyelination, neurodegeneration, and death. The disease
typically presents in young boys and adolescent boys.
Allogeneic bone marrow transplantation has been used to halt
progression of the disease. However, many patients lack
suitable HLA- matched related donors and must rely on
unmatched donors for a source of stem cells. The purpose of
this study was to evaluate outcomes of unrelated donor
umbilical cord blood transplantation after
chemotherapy-based myeloablative conditioning and
retrospectively determine if baseline studies correlate and
help predict outcome. Between November 22, 1996, and
November 3, 2005, 12 boys with X-linked ALD who lacked HL-
matched related donors were referred to Duke University
Medical Center for transplantation. These children were
conditioned with myeloablative therapy including busulfan,
cyclophosphamide, and antithymocyte globulin before
receiving umbilical cord-blood transplants from unrelated
donors. Baseline studies of neurophysiologic, neuroimaging,
and neurodevelopmental status were performed and patients
were subsequently evaluated for survival, engraftment,
graft-versus-host disease, and neurodevelopmental outcomes.
A substudy evaluated whether baseline neuroimaging and
neurophysiologic studies correlated with cognitive and motor
function and if these studies were predictive of
posttransplantation outcomes. The umbilical cord blood
grafts had normal levels of very long chain fatty acids.
They delivered a median of 6.98 x 10(7) nucleated cells per
kilogram of recipient body weight and were discordant for up
to 4 of 6 HLA markers. Neutrophil engraftment occurred at a
median of 22.9 days after transplantation. Three patients
had grade II-IV acute graft-versus-host disease; 2 had
extensive chronic graft-versus-host disease. Cumulative
incidence of overall survival of the group at 6 months is
66.7% (95% confidence interval 39.9-93.3%). Median follow-up
was 3.3 years (range 12 days to 6.3 years). As previously
reported with bone marrow transplantation, symptomatic
patients faired poorly with lower survival and rapid
deterioration of neurologic function. This study included 3
patients transplanted at a very young age (2.6-3.5 years)
before the onset of clinical symptoms who continue to
develop at a normal rate for 3-5 years posttransplant.
Although baseline Loes scores correlated with cognitive and
motor outcome, neurophysiologic studies failed to show
statistically significant differences. Transplantation of
boys with X-linked ALD using partial HLA-matched umbilical
cord blood yields similar results to those previously
reported after bone marrow transplantation. Superior
outcomes were seen in neurologically asymptomatic boys less
than 3.5 years of age at the time of transplantation.
Baseline Loes scores were a strong predictor of cognitive
and motor outcome.},
Language = {eng},
Doi = {10.1016/j.bbmt.2007.01.082},
Key = {fds148374}
}
@article{fds132223,
Author = {A Desjardins and JA Quinn and JJ Vredenburgh and S Sathornsumetee and AH
Friedman, JE Herndon and RE McLendon and JM Provenzale and JN Rich and JH Sampson and S Gururangan and JM Dowell and A Salvado and HS Friedman and DA Reardon},
Title = {Phase II study of imatinib mesylate and hydroxyurea for
recurrent grade III malignant gliomas.},
Journal = {Journal of neuro-oncology, Netherlands},
Volume = {83},
Number = {1},
Pages = {53-60},
Year = {2007},
Month = {May},
ISSN = {0167-594X},
Keywords = {Adult • Antineoplastic Agents • Antineoplastic
Combined Chemotherapy Protocols • Astrocytoma •
Central Nervous System Neoplasms • Female •
Follow-Up Studies • Humans • Hydroxyurea •
Male • Middle Aged • Neoplasm Recurrence, Local
• Oligodendroglioma • Piperazines • Prognosis
• Pyrimidines • Treatment Outcome •
administration & dosage • adverse effects • drug
therapy* • therapeutic use*},
Abstract = {PURPOSE: Recent reports demonstrate the activity of imatinib
mesylate, an ATP-mimetic, tyrosine kinase inhibitor, plus
hydroxyurea, a ribonucleotide reductase inhibitor, in
patients with recurrent glioblastoma multiforme. We
performed the current phase 2 study to evaluate this regimen
among patients with recurrent WHO grade III malignant glioma
(MG). PATIENTS AND METHOD: Patients with grade III MG at any
recurrence, received imatinib mesylate plus hydroxyurea (500
mg twice a day) orally on a continuous, daily schedule. The
imatinib mesylate dose was 500 mg twice a day for patients
on enzyme inducing anti-epileptic drugs (EIAEDs) and 400 mg
once a day for those not on EIAEDs. Clinical assessments
were performed monthly and radiographic assessments were
obtained at least every 2 months. The primary endpoint was
6-month progression-free survival (PFS) rate. RESULTS:
Thirty-nine patients were enrolled. All patients had
progressive disease after prior radiotherapy and at least
temozolomide-based chemotherapy. The median number of
episodes of prior progression was 2 (range, 1-7) and the
median number of prior treatment regimens was 3 (range,
1-8). With a median follow-up of 82.9 weeks, 24% of patients
were progression-free at 6 months. The radiographic response
rate was 10%, while 33% achieved stable disease. Among
patients who achieved at least stable disease at first
evaluation, the 6-month and 12-month PFS rates were 53% and
29%, respectively. The most common grade 3 or greater
toxicities were hematologic and complicated less than 4% of
administered courses. CONCLUSION: Imatinib mesylate plus
hydroxyurea, is well tolerated and associated with
anti-tumor activity in some patients with recurrent grade 3
MG.},
Key = {fds132223}
}
@article{fds148368,
Author = {JM Provenzale},
Title = {Ten principles to improve the likelihood of publication of a
scientific manuscript.},
Journal = {AJR. American journal of roentgenology, United
States},
Volume = {188},
Number = {5},
Pages = {1179-82},
Year = {2007},
Month = {May},
ISSN = {1546-3141},
Keywords = {Guidelines as Topic • Manuscripts as Topic •
Publications • Writing • standards*},
Abstract = {OBJECTIVE: The objective of this article is to discuss the
reasons that manuscripts fail to be published and to
establish some principles for increasing the likelihood of
publication. CONCLUSION: Many good manuscripts fail to be
published because they violate a few simple rules for
writing a superior journal article. This review presents 10
principles for increasing the likelihood of manuscript
publication.},
Key = {fds148368}
}
@article{fds148362,
Author = {KR Bulsara and A Zomorodi and JM Provenzale},
Title = {Anatomic variant of the posterior cerebral
artery.},
Journal = {AJR. American journal of roentgenology},
Volume = {188},
Number = {4},
Pages = {W395},
Year = {2007},
Month = {April},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.06.0991},
Keywords = {Humans • Posterior Cerebral Artery • anatomy &
histology* • radiography*},
Language = {eng},
Doi = {10.2214/AJR.06.0991},
Key = {fds148362}
}
@article{fds148367,
Author = {HE Rice and EW Hsu and H Sheng and DA Evenson and AJ Freemerman and KM
Safford, JM Provenzale and DS Warner and GA Johnson},
Title = {Superparamagnetic iron oxide labeling and transplantation of
adipose-derived stem cells in middle cerebral artery
occlusion-injured mice.},
Journal = {AJR. American journal of roentgenology, United
States},
Volume = {188},
Number = {4},
Pages = {1101-8},
Year = {2007},
Month = {April},
ISSN = {1546-3141},
Keywords = {Adipose Tissue • Animals • Brain Ischemia •
Contrast Media* • Infarction, Middle Cerebral Artery
• Iron • Magnetic Resonance Imaging* • Mice
• Mice, Inbred C57BL • Oxides • Stem Cell
Transplantation • complications* • cytology*
• diagnosis* • diagnostic use* • etiology
• methods* • surgery*},
Abstract = {OBJECTIVE: Adipose-derived stem cells are an alternative
stem cell source for CNS therapies. The goals of the current
study were to label adipose-derived stem cells with
superparamagnetic iron oxide (SPIO) particles, to use MRI to
guide the transplantation of adipose-derived stem cells in
middle cerebral artery occlusion (MCAO)-injured mice, and to
localize donor adipose-derived stem cells in the injured
brain using MRI. We hypothesized that we would successfully
label adipose-derived stem cells and image them with MRI.
MATERIALS AND METHODS: Adipose-derived stem cells harvested
from mice inbred for green fluorescent protein were labeled
with SPIO ferumoxide particles through the use of
poly-L-lysine. Adipose-derived stem cell viability, iron
staining, and proliferation were measured after SPIO
labeling, and the sensitivity of MRI in the detection of
SPIO-labeled adipose-derived stem cells was assessed ex
vivo. Adult mice (n = 12) were subjected to unilateral MCAO.
Two weeks later, in vivo 7-T MRI was performed to guide
stereotactic transplantation of SPIO-labeled adipose-derived
stem cells into brain tissue adjacent to the infarct. After
24 hours, the mice were sacrificed for high-resolution ex
vivo 7-T or 9.4-T MRI and histologic study. RESULTS:
Adipose-derived stem cells were efficiently labeled with
SPIO particles without loss of cell viability or
proliferation. Using MRI, we guided precise transplantation
of adipose-derived stem cells. MR images of mice given
injections of SPIO-labeled adipose-derived stem cells had
hypointense regions that correlated with the histologic
findings in donor cells. CONCLUSION: MRI proved useful in
transplantation of adipose-derived stem cells in vivo. This
imaging technique may be useful for studies of CNS stem cell
therapies.},
Key = {fds148367}
}
@article{fds132238,
Author = {DJ Madden and J Spaniol and WL Whiting and B Bucur and JM Provenzale and R
Cabeza, LE White and SA Huettel},
Title = {Adult age differences in the functional neuroanatomy of
visual attention: a combined fMRI and DTI
study.},
Journal = {Neurobiology of aging},
Volume = {28},
Number = {3},
Pages = {459-76},
Year = {2007},
Month = {March},
ISSN = {1558-1497},
url = {http://dx.doi.org/10.1016/j.neurobiolaging.2006.01.005},
Keywords = {Adult • Aging • Anisotropy • Attention •
Brain Mapping • Choice Behavior • Diffusion
Magnetic Resonance Imaging* • Female • Humans
• Image Processing, Computer-Assisted • Magnetic
Resonance Imaging* • Male • Multivariate Analysis
• Oxygen • Photic Stimulation • Reaction Time
• Statistics as Topic • Visual Cortex* •
Visual Perception • anatomy & histology • blood
• blood supply • metabolism • methods •
physiology • physiology*},
Abstract = {We combined measures from event-related functional magnetic
resonance imaging (fMRI), diffusion tensor imaging (DTI),
and cognitive performance (visual search response time) to
test the hypotheses that differences between younger and
older adults in top-down (goal-directed) attention would be
related to cortical activation, and that white matter
integrity as measured by DTI (fractional anisotropy, FA)
would be a mediator of this age-related effect. Activation
in frontal and parietal cortical regions was overall greater
for older adults than for younger adults. The relation
between activation and search performance supported the
hypothesis of age differences in top-down attention. When
the task involved top-down control (increased target
predictability), performance was associated with
frontoparietal activation for older adults, but with
occipital (fusiform) activation for younger adults. White
matter integrity (FA) exhibited an age-related decline that
was more pronounced for anterior brain regions than for
posterior regions, but white matter integrity did not
specifically mediate the age-related increase in activation
of the frontoparietal attentional network.},
Language = {eng},
Doi = {10.1016/j.neurobiolaging.2006.01.005},
Key = {fds132238}
}
@article{fds148372,
Author = {B Bucur and DJ Madden and J Spaniol and JM Provenzale and R Cabeza and LE
White, SA Huettel},
Title = {Age-related slowing of memory retrieval: Contributions of
perceptual speed and cerebral white matter
integrity.},
Journal = {Neurobiol Aging},
Year = {2007},
Month = {March},
ISSN = {1558-1497},
Abstract = {Previous research suggests that, in reaction time (RT)
measures of episodic memory retrieval, the unique effects of
adult age are relatively small compared to the effects aging
shares with more elementary abilities such as perceptual
speed. Little is known, however, regarding the mechanisms of
perceptual speed. We used diffusion tensor imaging (DTI) to
test the hypothesis that white matter integrity, as indexed
by fractional anisotropy (FA), serves as one mechanism of
perceptual slowing in episodic memory retrieval. Results
indicated that declines in FA in the pericallosal frontal
region and in the genu of the corpus callosum, but not in
other regions, mediated the relationship between perceptual
speed and episodic retrieval RT. This relation held, though
to a different degree, for both hits and correct rejections.
These findings suggest that white matter integrity in
prefrontal regions is one mechanism underlying the relation
between individual differences in perceptual speed and
episodic retrieval.},
Key = {fds148372}
}
@article{fds148377,
Author = {JH Sampson and R Raghavan and JM Provenzale and D Croteau and DA
Reardon, RE Coleman and I Rodríguez Ponce and I Pastan and RK Puri and C Pedain},
Title = {Induction of hyperintense signal on T2-weighted MR images
correlates with infusion distribution from intracerebral
convection-enhanced delivery of a tumor-targeted
cytotoxin.},
Journal = {AJR. American journal of roentgenology, United
States},
Volume = {188},
Number = {3},
Pages = {703-9},
Year = {2007},
Month = {March},
ISSN = {1546-3141},
Keywords = {Adult • Antineoplastic Agents • Brain • Brain
Neoplasms • Drug Delivery Systems • Exotoxins
• Female • Glioma • Humans •
Immunotoxins • Infusions, Intra-Arterial •
Interleukin-13 • Magnetic Resonance Imaging • Male
• Middle Aged • Reproducibility of Results •
Sensitivity and Specificity • Tissue Distribution
• administration & dosage • administration &
dosage* • drug effects • drug therapy* •
metabolism* • methods • methods* • pathology
• pharmacokinetics • pharmacokinetics* •
therapeutic use},
Abstract = {OBJECTIVE: Convection-enhanced delivery is a promising
approach to intracerebral drug delivery in which a fluid
pressure gradient is used to infuse therapeutic
macromolecules through an indwelling catheter into the
interstitial spaces of the brain. Our purpose was to test
the hypothesis that hyperintense signal changes on
T2-weighted images produced by such infusions can be used to
track drug distribution. SUBJECTS AND METHODS: Seven adults
with recurrent malignant glioma underwent concurrent
intracerebral infusions of the tumor-targeted cytotoxin
cintredekin besudotox and 123I-labeled human serum albumin.
The agents were administered through a total of 18 catheters
among the seven patients. Adequacy of distribution of drug
was determined by evidence of distribution of 123I-labeled
human serum albumin on SPECT images coregistered with MR
images. Qualitative analysis was performed by three blinded
observers. Quantitative analysis also was performed.
RESULTS: Infusions into 12 catheters produced
intraparenchymal distribution as seen on SPECT images, but
infusions into six catheters did not. At qualitative
assessment of signal changes on MR images, reviewers
correctly predicted which catheters would produce
extraparenchymal distribution and which catheters would
produce parenchymal distribution. Of the 12 infusions that
produced intraparenchymal distribution, four catheters had
been placed in regions of relatively normal signal intensity
and produced regions of newly increased signal intensity,
the volume of which highly correlated with the volume and
geometry of distribution on SPECT (r2 = 0.9502). Eight
infusions that produced intraparenchymal distribution were
performed in regions of preexisting hyperintense signal. In
these brains, additional signal changes were always
produced, but quantitative correlations between areas of
newly increased signal intensity and the volume and geometry
of distribution on SPECT could not be established.
CONCLUSION: Convection-enhanced infusions frequently do not
provide intraparenchymal drug distribution, and these
failures can be identified with MRI soon after infusion.
When infusions are performed into regions of normal signal
intensity, development of hyperintense signal change
strongly correlates with the volume and geometry of
distribution of infusate.},
Key = {fds148377}
}
@article{fds148365,
Author = {BL Marks and DJ Madden and B Bucur and JM Provenzale and LE White and R
Cabeza, SA Huettel},
Title = {Role of aerobic fitness and aging on cerebral white matter
integrity.},
Journal = {Annals of the New York Academy of Sciences},
Volume = {1097},
Pages = {171-4},
Year = {2007},
Month = {February},
ISSN = {0077-8923},
url = {http://dx.doi.org/10.1196/annals.1379.022},
Keywords = {Adult • Aerobiosis • Aged • Aging •
Anaerobic Threshold • Anisotropy • Body Mass Index
• Brain • Diffusion Magnetic Resonance Imaging
• Female • Humans • Male • Motor
Activity • Oxygen Consumption • Physical Fitness
• Sex Characteristics • growth & development*
• physiology • physiology*},
Abstract = {Neuroimaging research suggests that cerebral white matter
(WM) integrity, as reflected in fractional anisotropy (FA)
via diffusion tensor imaging (DTI), is decreased in older
adults, especially in the prefrontal regions of the brain.
Behavioral investigations of cognitive functioning suggest
that some aspects of cognition may be better preserved in
older adults who possess higher levels of aerobic fitness.
There are only a few studies, however, investigating
potential mechanisms for the improvements in aerobic
fitness. Our study suggests that greater aerobic fitness may
be related to greater WM integrity in select brain
regions.},
Language = {eng},
Doi = {10.1196/annals.1379.022},
Key = {fds148365}
}
@article{fds132226,
Author = {HF Keyserling and JM Provenzale},
Title = {Atypical imaging findings in a near-fatal case of posterior
reversible encephalopathy syndrome in a child.},
Journal = {AJR. American journal of roentgenology},
Volume = {188},
Number = {1},
Pages = {219-21},
Year = {2007},
Month = {January},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.05.0328},
Keywords = {Cerebellar Diseases • Child • Encephalocele •
Fatal Outcome • Heart Arrest • Humans • Male
• Syndrome • radiography*},
Language = {eng},
Doi = {10.2214/AJR.05.0328},
Key = {fds132226}
}
@article{fds132231,
Author = {JM Provenzale},
Title = {Morphology predicts oncology: a commentary on Vezina and
Sutton's article, "Prolactin-secreting pituitary
microadenomas: roentgenologic diagnosis".},
Journal = {AJR. American journal of roentgenology},
Volume = {188},
Number = {1},
Pages = {9-10},
Year = {2007},
Month = {January},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.06.0410},
Keywords = {Adenoma, Chromophobe • Amenorrhea •
Craniopharyngioma • Female • Hormones, Ectopic
• Humans • Lactation Disorders • Pituitary
Neoplasms • Pregnancy • Prolactin • Sella
Turcica • Tomography, X-Ray Computed •
complications* • etiology • etiology* •
radiography • radiography* • secretion •
secretion*},
Language = {eng},
Doi = {10.2214/AJR.06.0410},
Key = {fds132231}
}
@article{fds132241,
Author = {JM Provenzale},
Title = {Imaging of angiogenesis: clinical techniques and novel
imaging methods.},
Journal = {AJR. American journal of roentgenology},
Volume = {188},
Number = {1},
Pages = {11-23},
Year = {2007},
Month = {January},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.06.0280},
Keywords = {Humans • Image Enhancement • Magnetic Resonance
Imaging • Neoplasms • Neovascularization,
Pathologic • Physician's Practice Patterns •
Practice Guidelines as Topic • Tomography, X-Ray
Computed • blood supply* • diagnosis* •
methods*},
Abstract = {OBJECTIVE: A wide variety of antiangiogenic agents have been
developed for the treatment of neoplasms. Imaging studies
play an important role in assessing the effects of these
treatments. CONCLUSION: This review article introduces
radiologists to features of these therapies and the most
important clinical and preclinical imaging techniques for
evaluating antiangiogenic agents.},
Language = {eng},
Doi = {10.2214/AJR.06.0280},
Key = {fds132241}
}
@article{fds132232,
Author = {JM Provenzale},
Title = {Imagining imaging: radiology practice in
2050.},
Journal = {AJR. American journal of roentgenology},
Volume = {187},
Number = {6},
Pages = {1399-400},
Year = {2006},
Month = {December},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.06.5185},
Keywords = {Decision Making • Forecasting • Humans •
Information Services • Radiology •
instrumentation* • trends*},
Language = {eng},
Doi = {10.2214/AJR.06.5185},
Key = {fds132232}
}
@article{fds132222,
Author = {DL Greenberg and ME Payne, JR MacFall and JM Provenzale and DC
Steffens, RR Krishnan},
Title = {Differences in brain volumes among males and female
hormone-therapy users and nonusers.},
Journal = {Psychiatry research, Ireland},
Volume = {147},
Number = {2-3},
Pages = {127-34},
Year = {2006},
Month = {October},
ISSN = {0165-1781},
Keywords = {Aged • Brain • Cognition • Estradiol •
Estrogen Replacement Therapy • Estrogens, Conjugated
(USP) • Estrone • Female • Health Status
• Humans • Magnetic Resonance Imaging • Male
• Medroxyprogesterone 17-Acetate •
Neuropsychological Tests • administration & dosage
• analogs & derivatives • anatomy & histology*
• drug effects* • methods* • pharmacology
• physiology},
Abstract = {Numerous studies have shown gender differences in the brain
volumes of elderly adults. Some evidence shows that higher
estrogen levels may be neuroprotective, suggesting that
hormone therapy (HT) may in part be responsible for these
gender differences; however, few studies have examined the
relation between HT and brain volumes. Brain volumes of
caudate, putamen, hippocampus, gray matter, white matter,
white-matter lesions, and cerebrospinal fluid were measured
on magnetic resonance imaging scans. A comprehensive
neuropsychological battery was administered. Women were
separated into two groups based on HT use, and we used
multiple regression analyses to compare these groups with
one another and with men. Results of brain-volume
measurements showed that HT users had significantly less
gray matter and more cerebrospinal fluid than nonusers.
Results of the neuropsychological testing showed that HT
users performed better on the Shipley Vocabulary Test than
males did.},
Key = {fds132222}
}
@article{fds132234,
Author = {JM Provenzale and G York and MG Moya and L Parks and M Choma and S Kealey and P Cole and H Serajuddin},
Title = {Correlation of relative permeability and relative cerebral
blood volume in high-grade cerebral neoplasms.},
Journal = {AJR. American journal of roentgenology},
Volume = {187},
Number = {4},
Pages = {1036-42},
Year = {2006},
Month = {October},
ISSN = {1546-3141},
url = {http://dx.doi.org/10.2214/AJR.04.0676},
Keywords = {Adult • Angiogenesis Inhibitors • Blood Volume*
• Blood-Brain Barrier • Brain • Brain
Neoplasms • Capillary Permeability* •
Cerebrovascular Circulation • Contrast Media •
Female • Gadolinium DTPA • Glioblastoma •
Humans • Magnetic Resonance Angiography • Male
• Middle Aged • Phthalazines • Pyridines
• blood supply* • diagnostic use • drug
therapy • physiopathology • therapeutic
use},
Abstract = {OBJECTIVE: The purpose of this study was to correlate the
degree of contrast enhancement on dynamic contrast-enhanced
T1-weighted MRI and the relative cerebral blood volume
(rCBV) values on T2*-weighted MRI in patients with
high-grade brain neoplasms. METHODS: Ten patients with
biopsy-proven high-grade gliomas underwent dynamic
contrast-enhanced MRI using T1-weighted fast spoiled
gradient-echo technique (TR/TE, 8.3/1.5) during i.v.
infusion of 0.1 mmol/kg of MR contrast medium. This sequence
was followed within 5 minutes by dynamic susceptibility
contrast (DSC) imaging (1,500/80) during i.v. infusion of
0.2 mmol/kg of MR contrast medium. Dynamic contrast-enhanced
analysis was performed using the maximum-signal-intensity
algorithm, and DSC analysis was performed using the negative
enhancement integral program. For each tumor, we performed
two comparisons: first, the average dynamic
contrast-enhanced and rCBV values within a region of
interest drawn around the entire contrast-enhancing tumor on
a single image through the center of the lesion and, second,
the highest dynamic contrast-enhanced and highest rCBV
values within each tumor. Statistical analyses of the first
comparison were performed using Pearson's correlation
coefficient, R2 correlation coefficient, and Spearman's rank
correlation and for the second comparison using Kendall's
tau correlation. RESULTS: The mean signal intensity values
ranged between 3.48 and 7.16 SDs above baseline values
(mean, 4.89 SDs). The mean rCBV values ranged between 57.9%
and 122.7% of the normal lentiform nucleus (mean, 76.6%).
The Pearson's correlation coefficient was 0.867, the R2
correlation coefficient was 0.752, and the Spearman's rank
correlation was 0.794 (p = 0.001). Dynamic contrast-enhanced
values from the region of highest signal intensity ranged
between 7.7 and 48.6 SDs above baseline values (mean, 17.3
SDs). The highest rCBV values ranged between 105% and 400%
of the normal lentiform nucleus (mean, 292%). The
correlation was estimated to be 0.7778 and was statistically
significant at the 0.01 level of statistical significance (p
= 0.0035). CONCLUSIONS: We found a high correlation between
degree of contrast enhancement on dynamic contrast-enhanced
images and rCBV values in whole tumors and in regions having
the highest degree of contrast enhancement in this small
study. Our findings, which suggest that relative
permeability and rCBV values may be correlated in high-grade
glial neoplasms, deserve further study in a larger patient
population.},
Language = {eng},
Doi = {10.2214/AJR.04.0676},
Key = {fds132234}
}
@article{fds148361,
Author = {MJ Kim and JM Provenzale and M Law},
Title = {Magnetic resonance and diffusion tensor imaging in pediatric
white matter diseases.},
Journal = {Topics in magnetic resonance imaging : TMRI},
Volume = {17},
Number = {4},
Pages = {265-74},
Year = {2006},
Month = {August},
ISSN = {0899-3459},
url = {http://dx.doi.org/10.1097/01.rmr.0000248665.84211.0f},
Keywords = {Adolescent • Brain • Brain Diseases • Child
• Child, Preschool • Demyelinating Diseases •
Diffusion Magnetic Resonance Imaging* • Humans •
Infant • Infant, Newborn • Nerve Fibers,
Myelinated • diagnosis* • growth & development
• pathology • pathology* •
physiopathology},
Abstract = {The central nervous system undergoes profound and
predictable developmental changes during the first few years
of life that provide the structural and functional elements
necessary for normal neurological development. The
establishment and maturation of white matter pathways is a
critical component of the developing nervous system.
Diffusion tensor imaging (DTI) offers a noninvasive and
quantitative means for the evaluation of white matter
changes. DTI has contributed to the evaluation of a number
of childhood leukoencephalopathies; it has also been used to
follow brain maturation in abnormal states, such as
premature birth or early brain injury. Furthermore, it has
helped characterize the relation between white matter
integrity and cognitive abilities. In the future, DTI is
expected to play an increasingly large role in defining
developmental abnormalities at an early age and in assessing
therapies for pediatric disorders such as
leukodystrophies.},
Language = {eng},
Doi = {10.1097/01.rmr.0000248665.84211.0f},
Key = {fds148361}
}
@article{fds132224,
Author = {DA Reardon and JA Quinn and G Akabani and RE Coleman and AH Friedman and HS
Friedman, JE Herndon 2nd and RE McLendon and CN Pegram and JM
Provenzale, JM Dowell and JN Rich and JJ Vredenburgh and A
Desjardins, JH Sampson and S Gururangan and TZ Wong and MA
Badruddoja, XG Zhao and DD Bigner and MR Zalutsky},
Title = {Novel human IgG2b/murine chimeric antitenascin monoclonal
antibody construct radiolabeled with 131I and administered
into the surgically created resection cavity of patients
with malignant glioma: phase I trial results.},
Journal = {Journal of nuclear medicine : official publication, Society
of Nuclear Medicine},
Volume = {47},
Number = {6},
Pages = {912-8},
Year = {2006},
Month = {June},
ISSN = {0161-5505},
Keywords = {Adult • Aged • Animals • Antibodies,
Monoclonal • Body Burden • Brain Neoplasms •
Dose-Response Relationship, Radiation • Female •
Glioma • Humans • Injections, Intralesional •
Male • Maximum Tolerated Dose • Mice • Middle
Aged • Radiometry • Radiopharmaceuticals •
Radiotherapy Dosage • Survival Rate • Tissue
Distribution • Treatment Outcome • administration
& dosage • administration & dosage* • adverse
effects • metabolism* • pharmacokinetics •
pharmacokinetics* • radiotherapy*},
Abstract = {UNLABELLED: Results from animal experiments have shown that
human IgG2/mouse chimeric antitenascin 81C6 (ch81C6)
monoclonal antibody exhibited higher tumor accumulation and
enhanced stability compared with its murine parent. Our
objective was to determine the effect of these differences
on the maximum tolerated dose (MTD), pharmacokinetics,
dosimetry, and antitumor activity of (131)I-ch81C6
administered into the surgically created resection cavity
(SCRC) of malignant glioma patients. METHODS: In this phase
I trial, eligible patients received a single injection of
(131)I-ch81C6 administered through a Rickham catheter into
the SCRC. Patients were stratified as newly diagnosed and
untreated (stratum A), newly diagnosed after external beam
radiotherapy (XRT) (stratum B), and recurrent (stratum C).
(131)I-ch81C6 was administered either before (stratum A) or
after (stratum B) conventional XRT for newly diagnosed
patients. In addition, chemotherapy was prescribed for all
patients after (131)I-ch81C6 administration. Dose escalation
was performed independently for each stratum. Patients were
observed for toxicity and response until death or
progressive disease. RESULTS: We treated 47 patients with
(131)I-ch81C6 doses up to 4.44 GBq (120 mCi), including 35
with newly diagnosed tumors (strata A and B) and 12 with
recurrent disease (stratum C). Dose-limiting hematologic
toxicity defined the MTD to be 2.96 GBq (80 mCi) for all
patients, regardless of treatment strata. Neurologic
dose-limiting toxicity developed in 3 patients; however,
none required further surgery to debulk radiation necrosis.
Median survival was 88.6 wk and 65.0 wk for newly diagnosed
and recurrent patients, respectively. CONCLUSIONS: The MTD
of (131)I-ch81C6 is 2.96 GBq (80 mCi) because of
dose-limiting hematologic toxicity. Although encouraging
survival was observed, (131)I-ch81C6 was associated with
greater hematologic toxicity, probably due to the enhanced
stability of the IgG2 construct, than previously observed
with (131)I-murine 81C6.},
Language = {eng},
Key = {fds132224}
}
@article{fds132230,
Author = {JM Provenzale and RJ Stanley},
Title = {A systematic guide to reviewing a manuscript.},
Journal = {Journal of nuclear medicine technology},
Volume = {34},
Number = {2},
Pages = {92-9},
Year = {2006},
Month = {June},
ISSN = {0091-4916},
Keywords = {Guidelines as Topic* • Peer Review, Research •
Research Personnel • methods* •
standards},
Abstract = {OBJECTIVE: In this article, we provide a step-by-step guide
to reviewing a manuscript that we hope will improve the
quality of reviews for the AJR. CONCLUSION: We have provided
a detailed series of guidelines for providing excellent
reviews of manuscripts. The template we have provided can be
used to serve as a checklist for important questions to ask
about manuscripts during the review process. Finally, the
principles presented here also can be used as a guide for
authors by providing a list of important features to include
during manuscript preparation and thereby prospectively
address questions that good reviewers are likely to
ask.},
Language = {eng},
Key = {fds132230}
}
@article{fds132235,
Author = {JM Provenzale and S Mukundan and DP Barboriak},
Title = {Diffusion-weighted and perfusion MR imaging for brain tumor
characterization and assessment of treatment
response.},
Journal = {Radiology},
Volume = {239},
Number = {3},
Pages = {632-49},
Year = {2006},
Month = {June},
ISSN = {0033-8419},
url = {http://dx.doi.org/10.1148/radiol.2393042031},
Keywords = {Brain Neoplasms • Cerebrovascular Circulation •
Contrast Media • Diffusion Magnetic Resonance Imaging
• Humans • Magnetic Resonance Imaging •
Patient Care Planning • Permeability • Treatment
Outcome • diagnosis* • methods* • physiology
• physiopathology • therapy},
Abstract = {Diffusion-weighted magnetic resonance (MR) imaging and
perfusion MR imaging are advanced techniques that provide
information not available from conventional MR imaging. In
particular, these techniques have a number of applications
with regard to characterization of tumors and assessment of
tumor response to therapy. In this review, the authors
describe the fundamental principles of diffusion-weighted
and perfusion MR imaging and provide an overview of the ways
in which these techniques are being used to characterize
tumors by helping distinguish tumor types, assess tumor
grade, and attempt to determine tumor margins. In addition,
the role of these techniques for evaluating response to
tumor therapy is outlined.},
Language = {eng},
Doi = {10.1148/radiol.2393042031},
Key = {fds132235}
}
@article{fds132237,
Author = {JM Provenzale},
Title = {Approaches to imaging of the sella: notes on "the Volume of
the Sella Turcica".},
Journal = {AJR. American journal of roentgenology, United
States},
Volume = {186},
Number = {4},
Pages = {931-2},
Year = {2006},
Month = {April},
ISSN = {0361-803X},
Keywords = {Humans • Sella Turcica • anatomy & histology*
• radiography*},
Key = {fds132237}
}
@article{fds132240,
Author = {JS Pekala and S Gururangan and JM Provenzale and S
Mukundan},
Title = {Central nervous system extraosseous Ewing sarcoma:
radiologic manifestations of this newly defined pathologic
entity.},
Journal = {AJNR. American journal of neuroradiology, United
States},
Volume = {27},
Number = {3},
Pages = {580-3},
Year = {2006},
Month = {March},
ISSN = {0195-6108},
Keywords = {Brain Neoplasms • Child • Female • Humans
• Sarcoma, Ewing's • Tomography, X-Ray Computed*
• radiography*},
Abstract = {Although these entities are histologically similar, recent
advances in molecular genetics have allowed the distinction
of central nervous system extraosseous Ewing sarcoma
(CNS-EES) from central primitive neuroectodermal tumors
(c-PNET) including medulloblastoma and supratentorial PNET.
We present 2 cases of pathologically confirmed CNS-EES.
Knowledge of CNS-EES as a distinct entity enables the
neuroradiologist to suggest the proper diagnosis and the
need for special immuno-histochemical and molecular studies
to confirm the diagnosis. Because treatment and prognosis
are vastly different, the proper diagnosis of CNS-EES versus
c-PNET is critical.},
Key = {fds132240}
}
@article{fds132228,
Author = {S Mukundan and KB Ghaghada and CT Badea and CY Kao and LW Hedlund and JM
Provenzale, GA Johnson and E Chen and RV Bellamkonda and A
Annapragada},
Title = {A liposomal nanoscale contrast agent for preclinical CT in
mice.},
Journal = {AJR. American journal of roentgenology, United
States},
Volume = {186},
Number = {2},
Pages = {300-7},
Year = {2006},
Month = {February},
ISSN = {0361-803X},
Keywords = {Animals • Contrast Media • Image Processing,
Computer-Assisted • Liposomes • Mice •
Radiography, Thoracic • Tomography, X-Ray Computed*
• Triiodobenzoic Acids • chemistry •
pharmacokinetics*},
Abstract = {OBJECTIVE: The goal of this study was to determine if an
iodinated, liposomal contrast agent could be used for
high-resolution, micro-CT of low-contrast, small-size
vessels in a murine model. MATERIALS AND METHODS: A
second-generation, liposomal blood pool contrast agent
encapsulating a high concentration of iodine (83-105 mg
I/mL) was evaluated. A total of five mice weighing between
20 and 28 g were infused with equivalent volume doses (500
microL of contrast agent/25 g of mouse weight) and imaged
with our micro-CT system for intervals of up to 240 min
postinfusion. The animals were anesthetized, mechanically
ventilated, and vital signs monitored allowing for
simultaneous cardiac and respiratory gating of image
acquisition. RESULTS: Initial enhancement of about 900 H in
the aorta was obtained, which decreased to a plateau level
of approximately 800 H after 2 hr. Excellent contrast
discrimination was shown between the myocardium and cardiac
blood pool (650-700 H). No significant nephrogram was
identified, indicating the absence of renal clearance of the
agent. CONCLUSION: The liposomal-based iodinated contrast
agent shows long residence time in the blood pool, very high
attenuation within submillimeter vessels, and no significant
renal clearance rendering it an effective contrast agent for
murine vascular imaging using a micro-CT
scanner.},
Key = {fds132228}
}
@article{fds132233,
Author = {DA Reardon and JA Quinn and JJ Vredenburgh and S Gururangan and AH
Friedman, A Desjardins and S Sathornsumetee and JE Herndon and JM
Dowell, RE McLendon and JM Provenzale and JH Sampson and RP Smith and AJ
Swaisland, JS Ochs and P Lyons and S Tourt-Uhlig and DD Bigner and HS
Friedman, JN Rich},
Title = {Phase 1 trial of gefitinib plus sirolimus in adults with
recurrent malignant glioma.},
Journal = {Clinical cancer research : an official journal of the
American Association for Cancer Research, United
States},
Volume = {12},
Number = {3 Pt 1},
Pages = {860-8},
Year = {2006},
Month = {February},
ISSN = {1078-0432},
Keywords = {Administration, Oral • Adult • Aged •
Antineoplastic Combined Chemotherapy Protocols •
Dose-Response Relationship, Drug • Drug Administration
Schedule • Female • Glioma • Humans •
Male • Middle Aged • Quinazolines •
Recurrence • Sirolimus • Treatment Outcome •
Tumor Markers, Biological • administration & dosage*
• analysis • drug therapy* • therapeutic
use*},
Abstract = {PURPOSE: To determine the maximum tolerated dose (MTD) and
dose-limiting toxicity (DLT) of gefitinib, a receptor
tyrosine kinase inhibitor of the epidermal growth factor
receptor, plus sirolimus, an inhibitor of the mammalian
target of rapamycin, among patients with recurrent malignant
glioma. PATIENTS AND METHODS: Gefitinib and sirolimus were
administered on a continuous daily dosing schedule at dose
levels that were escalated in successive cohorts of
malignant glioma patients at any recurrence who were
stratified based on concurrent use of CYP3A-inducing
anticonvulsants [enzyme-inducing antiepileptic drugs,
(EIAED)]. Pharmacokinetic and archival tumor biomarker data
were also assessed. RESULTS: Thirty-four patients with
progressive disease after prior radiation therapy and
chemotherapy were enrolled, including 29 (85%) with
glioblastoma multiforme and 5 (15%) with anaplastic glioma.
The MTD was 500 mg of gefitinib plus 5 mg of sirolimus for
patients not on EIAEDs and 1,000 mg of gefitinib plus 10 mg
of sirolimus for patients on EIAEDs. DLTs included
mucositis, diarrhea, rash, thrombocytopenia, and
hypertriglyceridemia. Gefitinib exposure was not affected by
sirolimus administration but was significantly lowered by
concurrent EIAED use. Two patients (6%) achieved a partial
radiographic response, and 13 patients (38%) achieved stable
disease. CONCLUSION: We show that gefitinib plus sirolimus
can be safely coadministered on a continuous, daily dosing
schedule, and established the recommended dose level of
these agents in combination for future phase 2 clinical
trials.},
Key = {fds132233}
}
@article{fds132239,
Author = {JM Provenzale},
Title = {Good things come in small packages: a review of the
proceedings of the 2005 Academy of Molecular Imaging
Meeting.},
Journal = {AJR. American journal of roentgenology},
Volume = {186},
Number = {2},
Pages = {291-6},
Year = {2006},
Month = {February},
ISSN = {0361-803X},
url = {http://dx.doi.org/10.2214/AJR.05.1301},
Keywords = {Congresses as Topic • Contrast Media • Diagnostic
Imaging • Florida • Molecular Probe Techniques*
• trends*},
Language = {eng},
Doi = {10.2214/AJR.05.1301},
Key = {fds132239}
}
@article{fds132227,
Author = {DA Reardon and G Akabani and RE Coleman and AH Friedman and HS Friedman and JE Herndon 2nd and RE McLendon and CN Pegram and JM Provenzale and JA
Quinn, JN Rich and JJ Vredenburgh and A Desjardins and S Gururangan and S Guruangan and M Badruddoja and JM Dowell and TZ Wong and XG Zhao and MR
Zalutsky, DD Bigner},
Title = {Salvage radioimmunotherapy with murine iodine-131-labeled
antitenascin monoclonal antibody 81C6 for patients with
recurrent primary and metastatic malignant brain tumors:
phase II study results.},
Journal = {Journal of clinical oncology : official journal of the
American Society of Clinical Oncology},
Volume = {24},
Number = {1},
Pages = {115-22},
Year = {2006},
Month = {January},
ISSN = {1527-7755},
url = {http://dx.doi.org/10.1200/JCO.2005.03.4082},
Keywords = {Adult • Aged • Antibodies, Monoclonal •
Biopsy • Brain Neoplasms • Female • Humans
• Iodine Radioisotopes • Male • Middle Aged
• Neoplasm Metastasis • Neoplasm Recurrence, Local
• Radioimmunotherapy* • Salvage Therapy •
Tenascin • adverse effects • immunology* •
mortality • pathology • radiotherapy* •
therapeutic use*},
Abstract = {OBJECTIVE: To assess the efficacy and toxicity of
intraresection cavity iodine-131-labeled murine antitenascin
monoclonal antibody 81C6 (131I-m81C6) among recurrent
malignant brain tumor patients. METHODS: In this phase II
trial, 100 mCi of 131I-m81C6 was injected directly into the
surgically created resection cavity (SCRC) of 43 patients
with recurrent malignant glioma (glioblastoma multiforme
[GBM], n = 33; anaplastic astrocytoma [AA], n = 6;
anaplastic oligodendroglioma [AO], n = 2; gliosarcoma [GS],
n = 1; and metastatic adenocarcinoma, n = 1) followed by
chemotherapy. RESULTS: With a median follow-up of 172 weeks,
63% and 59% of patients with GBM/GS and AA/AO tumors were
alive at 1 year. Median overall survival for patients with
GBM/GS and AA/AO tumors was 64 and 99 weeks, respectively.
Ten patients (23%) developed acute hematologic toxicity.
Five patients (12%) developed acute reversible
neurotoxicity. One patient (2%) developed irreversible
neurotoxicity. No patients required reoperation for
radionecrosis. CONCLUSIONS: In this single-institution phase
II study, administration of 100 mCi of 131I-m81C6 to
recurrent malignant glioma patients followed by chemotherapy
is associated with a median survival that is greater than
that of historical controls treated with surgery plus
iodine-125 brachytherapy. Furthermore, toxicity was
acceptable. Administration of a fixed millicurie dose
resulted in a wide range of absorbed radiation doses to the
SCRC. We are now conducting a phase II trial, approved by
the US Food and Drug Administration, using patient-specific
131I-m81C6 dosing, to deliver 44 Gy to the SCRC followed by
standardized chemotherapy. A phase III multicenter trial
with patient-specific dosing is planned.},
Language = {eng},
Doi = {10.1200/JCO.2005.03.4082},
Key = {fds132227}
}
@article{fds132236,
Author = {DA Reardon and MJ Egorin and JA Quinn and JN Rich and JN Rich Sr and S
Gururangan, I Gururangan and JJ Vredenburgh and A Desjardins and S
Sathornsumetee, JM Provenzale and JE Herndon 2nd and JM Dowell and MA
Badruddoja, RE McLendon and TF Lagattuta and KP Kicielinski and G
Dresemann, JH Sampson and AH Friedman and AJ Salvado and HS
Friedman},
Title = {Phase II study of imatinib mesylate plus hydroxyurea in
adults with recurrent glioblastoma multiforme.},
Journal = {Journal of clinical oncology : official journal of the
American Society of Clinical Oncology},
Volume = {23},
Number = {36},
Pages = {9359-68},
Year = {2005},
Month = {December},
ISSN = {0732-183X},
url = {http://dx.doi.org/10.1200/JCO.2005.03.2185},
Keywords = {Administration, Oral • Adult • Aged •
Antineoplastic Agents • Antineoplastic Combined
Chemotherapy Protocols • Brain Neoplasms • Disease
Progression • Drug Administration Schedule •
Female • Glioblastoma • Humans • Hydroxyurea
• Male • Middle Aged • Piperazines •
Pyrimidines • Survival Analysis • administration &
dosage • drug therapy* • pathology •
therapeutic use*},
Abstract = {OBJECTIVE: We performed a phase II study to evaluate the
combination of imatinib mesylate, an adenosine triphosphate
mimetic, tyrosine kinase inhibitor, plus hydroxyurea, a
ribonucleotide reductase inhibitor, in patients with
recurrent glioblastoma multiforme (GBM). METHODS: Patients
with GBM at any recurrence received imatinib mesylate plus
hydroxyurea (500 mg twice a day) orally on a continuous,
daily schedule. The imatinib mesylate dose was 500 mg twice
a day for patients on enzyme-inducing antiepileptic drugs
(EIAEDs) and 400 mg once a day for those not on EIAEDs.
Assessments were performed every 28 days. The primary end
point was 6-month progression-free survival (PFS). RESULTS:
Thirty-three patients enrolled with progressive disease
after prior radiotherapy and at least temozolomide-based
chemotherapy. With a median follow-up of 58 weeks, 27% of
patients were progression-free at 6 months, and the median
PFS was 14.4 weeks. Three patients (9%) achieved
radiographic response, and 14 (42%) achieved stable disease.
Cox regression analysis identified concurrent EIAED use and
no more than one prior progression as independent positive
prognostic factors of PFS. The most common toxicities
included grade 3 neutropenia (16%), thrombocytopenia (6%),
and edema (6%). There were no grade 4 or 5 events.
Concurrent EIAED use lowered imatinib mesylate exposure.
Imatinib mesylate clearance was decreased at day 28 compared
with day 1 in all patients, suggesting an effect of
hydroxyurea. CONCLUSIONS: Imatinib mesylate plus hydroxyurea
is well tolerated and associated with durable antitumor
activity in some patients with recurrent
GBM.},
Language = {eng},
Doi = {10.1200/JCO.2005.03.2185},
Key = {fds132236}
}
@article{fds132191,
Author = {JL Beyer and WD Taylor, JR MacFall and M Kuchibhatla and ME Payne and JM
Provenzale, F Cassidy and KR Krishnan},
Title = {Cortical white matter microstructural abnormalities in
bipolar disorder.},
Journal = {Neuropsychopharmacology : official publication of the
American College of Neuropsychopharmacology},
Volume = {30},
Number = {12},
Pages = {2225-9},
Year = {2005},
Month = {December},
ISSN = {0893-133X},
url = {http://dx.doi.org/10.1038/sj.npp.1300802},
Keywords = {Adult • Affect • Aged • Aged, 80 and over
• Anisotropy • Bipolar Disorder • Brain
• Diffusion Magnetic Resonance Imaging • Female
• Humans • Image Processing, Computer-Assisted
• Male • Middle Aged • Prefrontal Cortex
• pathology • pathology* •
ultrastructure},
Abstract = {This article reports on preliminary findings describing
microstructural abnormalities in the white matter of
cortical areas thought to be associated with bipolar
disorder. In all, 14 patients with bipolar disorder and 21
nonpsychiatrically ill control subjects underwent MR imaging
including a diffusion tensor imaging (DTI) pulse sequence
(six directions, b=1000 mm(2)/s). DTI data were analyzed on
a workstation using a program that allowed calculation of
apparent diffusion coefficient (ADC) and fractional
anisotropy (FA) within the following three white matter
fiber tracts bilaterally: the orbital frontal cortex, and
the superior and middle frontal gyri. These values were
compared across patient groups. The left and right orbital
frontal white matter exhibited significantly higher ADC
values in bipolar subjects than control subjects on both the
left (p=0.028) and right (p=0.011). Microstructural changes
in the white matter of the orbital frontal areas as
reflected by increased ADC values appear to be associated
with bipolar disorder. Further research is needed to better
understand the interaction of microstructural changes and
bipolar symptoms and whether these changes are specific to
bipolar disorder.},
Language = {eng},
Doi = {10.1038/sj.npp.1300802},
Key = {fds132191}
}
@article{fds132229,
Author = {JM Provenzale and M Escolar and J Kurtzberg},
Title = {Quantitative analysis of diffusion tensor imaging data in
serial assessment of Krabbe disease.},
Journal = {Annals of the New York Academy of Sciences},
Volume = {1064},
Pages = {220-9},
Year = {2005},
Month = {December},
ISSN = {0077-8923},
url = {http://dx.doi.org/10.1196/annals.1340.040},
Keywords = {Anisotropy • Brain • Brain Mapping •
Diffusion Magnetic Resonance Imaging • Humans •
Infant, Newborn • Leukodystrophy, Globoid Cell •
Nerve Fibers, Myelinated • Recovery of Function •
Stem Cell Transplantation • Stem Cells • Treatment
Outcome • cytology • diagnosis* • methods
• methods* • pathology • pathology* •
physiology • physiopathology •
therapy*},
Abstract = {Krabbe disease is a rare autosomal recessive pediatric white
matter (WM) disorder that is due to deficiency of a specific
enzyme, beta-galactocerebrosidase. This report reviews our
experience with use of diffusion tensor imaging (DTI) in
serial assessment of WM changes in Krabbe disease following
stem cell transplantation. DTI appears to be a sensitive
means to monitor effects of stem cell transplantation on WM
development in Krabbe disease. The group of early
transplantation infants was clearly distinguishable from the
group of late transplantation infants based on anisotropy
measurements. Good correlation also was seen between
neurodevelopmental scores and anisotropy measurements. The
work described here in Krabbe disease may serve as a model
for application of DTI to other therapies in various WM
disorders such as multiple sclerosis and dysmyelinating
disorders of childhood.},
Language = {eng},
Doi = {10.1196/annals.1340.040},
Key = {fds132229}
}
@article{fds132218,
Author = {JM Provenzale and RJ Stanley},
Title = {A systematic guide to reviewing a manuscript.},
Journal = {AJR. American journal of roentgenology},
Volume = {185},
Number = {4},
Pages = {848-54},
Year = {2005},
Month = {October},
ISSN = {0361-803X},
url = {http://dx.doi.org/10.2214/AJR.05.0782},
Keywords = {Humans • Manuscripts, Medical* • Peer Review,
Research • Periodicals as Topic • Publishing
• methods* • standards*},
Abstract = {OBJECTIVE: In this article, we provide a step-by-step guide
to reviewing a manuscript that we hope will improve the
quality of reviews for the AJR. CONCLUSION: We have provided
a detailed series of guidelines for providing excellent
reviews of manuscripts. The template we have provided can be
used to serve as a checklist for important questions to ask
about manuscripts during the review process. Finally, the
principles presented here also can be used as a guide for
authors by providing a list of important features to include
during manuscript preparation and thereby prospectively
address questions that good reviewers are likely to
ask.},
Language = {eng},
Doi = {10.2214/AJR.05.0782},
Key = {fds132218}
}
@article{fds132219,
Author = {JA Quinn and A Desjardins and J Weingart and H Brem and ME Dolan and SM
Delaney, J Vredenburgh and J Rich and AH Friedman and DA Reardon and JH
Sampson, AE Pegg and RC Moschel and R Birch and RE McLendon and JM
Provenzale, S Gururangan and JE Dancey and J Maxwell and S
Tourt-Uhlig, JE Herndon 2nd and DD Bigner and HS
Friedman},
Title = {Phase I trial of temozolomide plus O6-benzylguanine for
patients with recurrent or progressive malignant
glioma.},
Journal = {Journal of clinical oncology : official journal of the
American Society of Clinical Oncology},
Volume = {23},
Number = {28},
Pages = {7178-87},
Year = {2005},
Month = {October},
ISSN = {0732-183X},
url = {http://dx.doi.org/10.1200/JCO.2005.06.502},
Keywords = {Adult • Aged • Antineoplastic Combined
Chemotherapy Protocols • Brain Neoplasms •
Dacarbazine • Disease Progression • Female •
Glioma • Guanine • Humans • Infusions,
Intravenous • Injections, Intravenous • Male
• Maximum Tolerated Dose • Middle Aged •
administration & dosage • adverse effects •
analogs & derivatives • drug therapy* • pathology
• pharmacokinetics • therapeutic
use*},
Abstract = {OBJECTIVE: We conducted a two-phase clinical trial in
patients with progressive malignant glioma (MG). The first
phase of this trial was designed to determine the dose of
O6-BG effective in producing complete depletion of tumor AGT
activity for 48 hours. The second phase of the trial was
designed to define the maximum tolerated dose (MTD) of a
single dose of temozolomide when combined with O6-BG. In
addition, plasma concentrations of O6-BG and
O6-benzyl-8-oxoguanine were evaluated after O6-BG. METHODS:
For our first phase of the clinical trial, patients were
scheduled to undergo craniotomy for AGT determination after
receiving a 1-hour O6-BG infusion at 120 mg/m2 followed by a
continuous infusion at an initial dose of 30 mg/m2/d for 48
hours. The dose of the continuous infusion of O6-BG
escalated until tumor AGT was depleted. Once the O6-BG dose
was established a separate group of patients was enrolled in
the second phase of clinical trial, in which temozolomide,
administered as a single dose at the end of the 1-hour O6-BG
infusion, was escalated until the MTD was determined.
RESULTS: The O6-BG dose found to be effective in depleting
tumor AGT activity at 48 hours was an IV bolus of 120 mg/m2
over 1 hour followed by a continuous infusion of 30 mg/m2/d
for 48 hours. On enrolling 38 patients in six dose levels of
temozolomide, the MTD was established at 472 mg/m2 with
dose-limiting toxicities limited to myelosuppression.
CONCLUSIONS: This study provides the foundation for a phase
II trial of O6-BG plus temozolomide in temozolomide-resistant
MG.},
Language = {eng},
Doi = {10.1200/JCO.2005.06.502},
Key = {fds132219}
}
@article{fds132188,
Author = {JM Provenzale and S Mukundan and M Dewhirst},
Title = {The role of blood-brain barrier permeability in brain tumor
imaging and therapeutics.},
Journal = {AJR. American journal of roentgenology},
Volume = {185},
Number = {3},
Pages = {763-7},
Year = {2005},
Month = {September},
ISSN = {0361-803X},
url = {http://dx.doi.org/10.2214/ajr.185.3.01850763},
Keywords = {Animals • Biological Transport • Blood-Brain
Barrier • Brain Neoplasms • Contrast Media •
Humans • Magnetic Resonance Imaging* •
Neovascularization, Pathologic • Permeability •
diagnosis • diagnosis* • physiology* •
physiopathology • therapy • therapy*},
Abstract = {OBJECTIVE: Our purpose is to describe methods of assessing
leakiness of the blood-brain barrier and explain mechanisms
for exploiting the blood-brain barrier for therapeutic
purposes. CONCLUSION: Knowledge of the workings of the
blood-brain barrier is important for an understanding of the
ways in which blood-brain barrier permeability may be used
as a surrogate marker for drug therapeutic response.
Manipulation of the blood-brain barrier may provide a means
for selectively targeting tumors for drug
delivery.},
Language = {eng},
Doi = {10.2214/ajr.185.3.01850763},
Key = {fds132188}
}
@article{fds132197,
Author = {SM Kealey and Y Kim and WL Whiting and DJ Madden and JM
Provenzale},
Title = {Determination of multiple sclerosis plaque size with
diffusion-tensor MR Imaging: comparison study with healthy
volunteers.},
Journal = {Radiology},
Volume = {236},
Number = {2},
Pages = {615-20},
Year = {2005},
Month = {August},
ISSN = {0033-8419},
url = {http://dx.doi.org/10.1148/radiol.2362040014},
Keywords = {Adult • Diffusion Magnetic Resonance Imaging* •
Female • Humans • Male • Middle Aged •
Multiple Sclerosis • Retrospective Studies •
pathology*},
Abstract = {OBJECTIVE: To use diffusion-tensor magnetic resonance (MR)
imaging to measure involvement of normal-appearing white
matter (WM) immediately adjacent to multiple sclerosis (MS)
plaques and thus redefine actual plaque size on
diffusion-tensor images through comparison with T2-weighted
images of equivalent areas in healthy volunteers. METHODS:
Informed consent was not required given the retrospective
nature of the study on an anonymized database. The study
complied with requirements of the Health Insurance
Portability and Accountability Act. Twelve patients with MS
(four men, eight women; mean age, 35 years) and 14 healthy
volunteers (six men, eight women; mean age, 25 years) were
studied. The authors obtained fractional anisotropy (FA)
values in MS plaques and in the adjacent normal-appearing WM
in patients with MS and in equivalent areas in healthy
volunteers. They placed regions of interest (ROIs) around
the periphery of plaques and defined the total ROIs (ie,
plaques plus peripheral ROIs) as abnormal if their mean FA
values were at least 2 standard deviations below those of
equivalent ROIs within equivalent regions in healthy
volunteers. The combined area of the plaque and the
peripheral ROI was compared with the area of the plaque seen
on T2-weighted MR images by means of a Student paired t test
(P = .05). RESULTS: The mean plaque size on T2-weighted
images was 72 mm2 +/- 21 (standard deviation). The mean
plaque FA value was 0.285 +/- 0.088 (0.447 +/- 0.069 in
healthy volunteers [P < .001]; mean percentage reduction in
FA in MS plaques, 37%). The mean plaque size on FA maps was
91 mm2 +/- 35, a mean increase of 127% compared with the
size of the original plaque on T2-weighted images (P = .03).
CONCLUSIONS: A significant increase in plaque size was seen
when normal-appearing WM was interrogated with
diffusion-tensor MR imaging. This imaging technique may
represent a more sensitive method of assessing disease
burden and may have a future role in determining disease
burden and activity.},
Language = {eng},
Doi = {10.1148/radiol.2362040014},
Key = {fds132197}
}
@article{fds132213,
Author = {P McGraw and L Liang and M Escolar and S Mukundan and J Kurtzberg and JM
Provenzale},
Title = {Krabbe disease treated with hematopoietic stem cell
transplantation: serial assessment of anisotropy
measurements--initial experience.},
Journal = {Radiology},
Volume = {236},
Number = {1},
Pages = {221-30},
Year = {2005},
Month = {July},
ISSN = {0033-8419},
url = {http://dx.doi.org/10.1148/radiol.2353040716},
Keywords = {Anisotropy • Diffusion Magnetic Resonance Imaging*
• Female • Hematopoietic Stem Cell
Transplantation* • Humans • Infant •
Leukodystrophy, Globoid Cell • Male • Prospective
Studies • Treatment Outcome • pathology •
therapy*},
Abstract = {OBJECTIVE: To prospectively compare diffusion-tensor
magnetic resonance (MR) imaging anisotropy measurements of
white matter (WM) regions in early and late treatment groups
of Krabbe disease patients treated with stem cell
transplantation. METHODS: The study was approved by the
Institutional Review Board and was compliant with Health
Insurance Portability and Accountability Act; informed
consent was obtained from the families of all patients.
Patients with early-onset Krabbe disease (four girls and
three boys) underwent diffusion-tensor MR imaging before and
after stem cell transplantation. Fractional anisotropy (FA)
values from serial studies were compared in patients who
underwent transplantation at less than 1 month (early group,
two girls and one boy) and those who underwent
transplantation at 5-8 months (late group, two girls and two
boys). FA values were measured in the genu and splenium of
the corpus callosum, the frontal WM, and the internal
capsule; were compared with those of five age-matched
children in the comparison group (normal MR images and no
proved neurologic disease); and were expressed as a ratio.
Images obtained after transplantation were evaluated at
approximately 1 (n = 7), 2 (n = 6), 3 (n = 1), and 4 (n = 1)
years. RESULTS: Before transplantation, mean FA ratios in
the early group for all four WM regions ranged between 97%
and 117%. At 1 year, mean FA ratios at all locations were
either 92% or 93%. At 2 years after transplantation, mean FA
ratios were between 83% and 92%. In one patient imaged at 3
years, the mean FA ratio was 97%; in another patient imaged
at 4 years, the mean FA ratio was 77%. Before
transplantation, mean FA ratios in the late group ranged
between 55% and 74%. Mean FA ratios were between 37% and 50%
at 1 year after transplantation and between 36% and 39% at 2
years. CONCLUSIONS: All patients had decreases in FA ratios
over time. The early group had higher initial FA ratios and
lower subsequent decreases, which may indicate amelioration
of the dysmyelinating process.},
Language = {eng},
Doi = {10.1148/radiol.2353040716},
Key = {fds132213}
}
@article{fds132192,
Author = {G Akabani and DA Reardon and RE Coleman and TZ Wong and SD Metzler and JE
Bowsher, DP Barboriak and JM Provenzale and KL Greer and D DeLong and HS
Friedman, AH Friedman and XG Zhao and CN Pegram and RE McLendon and DD
Bigner, MR Zalutsky},
Title = {Dosimetry and radiographic analysis of 131I-labeled
anti-tenascin 81C6 murine monoclonal antibody in newly
diagnosed patients with malignant gliomas: a phase II
study.},
Journal = {Journal of nuclear medicine : official publication, Society
of Nuclear Medicine},
Volume = {46},
Number = {6},
Pages = {1042-51},
Year = {2005},
Month = {June},
ISSN = {0161-5505},
Keywords = {Adult • Aged • Animals • Antibodies,
Monoclonal • Brain • Brain Neoplasms • Female
• Glioma • Humans • Iodine Radioisotopes
• Magnetic Resonance Imaging • Male • Mice
• Middle Aged • Neoplasm Recurrence, Local •
Positron-Emission Tomography • Radioimmunotherapy*
• Radiometry • Reoperation • Tenascin •
adverse effects • immunology • immunology* •
pathology • radionuclide imaging • radiotherapy*
• therapeutic use • therapeutic
use*},
Abstract = {UNLABELLED: The objective was to perform dosimetry and
evaluate dose-response relationships in newly diagnosed
patients with malignant brain tumors treated with direct
injections of (131)I-labeled anti-tenascin murine 81C6
monoclonal antibody (mAb) into surgically created resection
cavities (SCRCs) followed by conventional external-beam
radiotherapy and chemotherapy. METHODS: Absorbed doses to
the 2-cm-thick shell, measured from the margins of the
resection cavity interface, were estimated for 33 patients
with primary brain tumors. MRI/SPECT registrations were used
to assess the distribution of the radiolabeled mAb in brain
parenchyma. Results from biopsies obtained from 15 patients
were classified as tumor, radionecrosis, or tumor and
radionecrosis, and these were correlated with absorbed dose
and dose rate. Also, MRI/PET registrations were used to
assess radiographic progression among patients. RESULTS:
This therapeutic strategy yielded a median survival of 86
and 79 wk for all patients and glioblastoma multiforme (GBM)
patients, respectively. The average SCRC residence time of
(131)I-mu81C6 mAb was 76 h (range, 34-169 h). The average
absorbed dose to the 2-cm cavity margins was 48 Gy (range,
25-116 Gy) for all patients and 51 Gy (range, 27-116 Gy) for
GBM patients. In MRI/SPECT registrations, we observed a
preferential distribution of (131)I-mu81C6 mAb through
regions of vasogenic edema. An analysis of the relationship
between the absorbed dose and dose rate and the first biopsy
results yielded a most favorable absorbed dose of 44 Gy. A
correlation between decreased survival and irreversible
neurotoxicity was noted. A comparative analysis, in terms of
median survival, was performed with previous brachytherapy
clinical studies, which showed a proportional relationship
between the average boost absorbed dose and the median
survival. CONCLUSIONS: This study shows that (131)I-mu81C6
mAb increases the median survival of GBM patients. An
optimal absorbed dose of 44 Gy to the 2-cm cavity margins is
suggested to reduce the incidence of neurologic toxicity.
Further clinical studies are warranted to determine the
effectiveness of (131)I-mu81C6 mAb based on a target dose of
44 Gy rather than a fixed administered activity.},
Language = {eng},
Key = {fds132192}
}
@article{fds132201,
Author = {MA Kliewer and KS Freed and DM DeLong and PJ Pickhardt and JM
Provenzale},
Title = {Reviewing the reviewers: comparison of review quality and
reviewer characteristics at the American Journal of
Roentgenology.},
Journal = {AJR. American journal of roentgenology, United
States},
Volume = {184},
Number = {6},
Pages = {1731-5},
Year = {2005},
Month = {June},
ISSN = {0361-803X},
Keywords = {Female • Humans • Male • Manuscripts,
Medical* • Middle Aged • Peer Review, Research*
• Periodicals • Publishing • Questionnaires
• Radiology* • standards*},
Abstract = {OBJECTIVE: The purpose of our study was to determine which
manuscript reviewer characteristics are most strongly
associated with reviewer performance as judged by editors of
the American Journal of Roentgenology (AJR). MATERIALS AND
METHODS: At the AJR, manuscript reviews are rated by the
journal editors on a subjective scale from 1 (lowest) to 4,
on the basis of the value, thoroughness, and punctuality of
the critique. We obtained all scores for AJR reviewers and
determined the average score for each reviewer. We also sent
a questionnaire to 989 reviewers requesting specific
information regarding the age, sex, radiology subspecialty,
number of years serving as a reviewer, academic rank, and
practice type of the reviewer. The demographic profiles were
correlated with the average quality score for each reviewer.
Statistical analysis included correlation analysis and
analysis of variance modeling. Reviewer quality scores were
also correlated with the scoring of individual reviews and
ultimate disposition of 196 manuscripts sent to the AJR
during the same period. RESULTS: Responses to the
questionnaire were obtained from 821 reviewers (83.0%), for
whom quality scores were available for 714 (87.0%).
Correlation analysis shows that the quality score of
reviewers strongly correlated with younger age (p = 0.001).
A statistically significant correlation between quality
score and practice type was seen (p = 0.008), with reviewers
from academic institutions receiving higher scores. No
significant correlation was found between quality score and
sex (p = 0.72), years of reviewing (p = 0.26), academic rank
(p = 0.10), or the ultimate disposition of the manuscript (p
= 0.40). The quality score of the reviewers showed no
variation by subspecialty (p = 0.99). CONCLUSION: The
highest-rated AJR reviewers tended to be young and from
academic institutions. The quality of peer review did not
correlate with the sex, academic rank, or subspecialty of
the reviewer.},
Key = {fds132201}
}
@article{fds132216,
Author = {JM Provenzale and S Mukundan},
Title = {Getting small is suddenly very big: review of the
proceedings of the third annual meeting of the Society for
Molecular Imaging.},
Journal = {AJR. American journal of roentgenology},
Volume = {184},
Number = {6},
Pages = {1736-9},
Year = {2005},
Month = {June},
ISSN = {0361-803X},
url = {http://dx.doi.org/10.2214/ajr.184.6.01841736},
Keywords = {Diagnostic Imaging* • Humans • Molecular Biology*
• Molecular Diagnostic Techniques • Societies,
Medical* • Technology, Radiologic •
trends},
Language = {eng},
Doi = {10.2214/ajr.184.6.01841736},
Key = {fds132216}
}
@article{fds132205,
Author = {WD Taylor, JR MacFall and ME Payne and DR McQuoid and DC Steffens and JM
Provenzale, RR Krishnan},
Title = {Greater MRI lesion volumes in elderly depressed subjects
than in control subjects.},
Journal = {Psychiatry research},
Volume = {139},
Number = {1},
Pages = {1-7},
Year = {2005},
Month = {May},
ISSN = {0165-1781},
url = {http://dx.doi.org/10.1016/j.pscychresns.2004.08.004},
Keywords = {Aged • Brain • Depressive Disorder, Major •
Female • Functional Laterality • Humans •
Magnetic Resonance Imaging* • Male • Middle Aged
• Questionnaires • diagnosis* • pathology*
• physiology},
Abstract = {Hyperintense lesions in both white matter and gray matter on
T2-weighted magnetic resonance imaging (MRI) are associated
with late-life depression. This large study examined
differences in gray and white matter lesion volumes on brain
MRI between 253 elderly depressed and 146 control subjects.
White matter and gray matter lesion volumes were measured in
each hemisphere using a semi-automated segmentation process
and compared against depression status. Depressed subjects
exhibited significantly greater total white matter (mean
7.22 ml) and gray matter (mean 0.30 ml) lesion volumes in
both hemispheres than did control subjects (mean 4.87 ml in
white matter and 0.18 ml in gray matter). This difference
remained statistically significant even after controlling
for confounders such as age, sex, race and reports of
hypertension, diabetes and heart disease. Patients with
late-life depression have larger white matter lesion and
gray matter lesion volumes than do control subjects. Future
research should combine similar volumetric techniques with
methods of identifying the location of lesions specific to
late-life depression.},
Language = {eng},
Doi = {10.1016/j.pscychresns.2004.08.004},
Key = {fds132205}
}
@article{fds132187,
Author = {SM Kealey and T Aho and D Delong and DP Barboriak and JM Provenzale and JD
Eastwood},
Title = {Assessment of apparent diffusion coefficient in normal and
degenerated intervertebral lumbar disks: initial
experience.},
Journal = {Radiology},
Volume = {235},
Number = {2},
Pages = {569-74},
Year = {2005},
Month = {May},
ISSN = {0033-8419},
url = {http://dx.doi.org/10.1148/radiol.2352040437},
Keywords = {Adult • Aged • Aged, 80 and over • Diffusion
Magnetic Resonance Imaging* • Female • Humans
• Image Enhancement* • Image Processing,
Computer-Assisted* • Intervertebral Disk • Lumbar
Vertebrae • Male • Middle Aged • Prospective
Studies • Reference Values • Spinal Osteophytosis
• diagnosis* • pathology*},
Abstract = {OBJECTIVE: To determine prospectively the diffusibility of
water in normal lumbar disks in adults by using the mean
apparent diffusion coefficient (ADC) and to determine if a
relationship exists between disk ADC and magnetic resonance
(MR) findings of disk degeneration. METHODS: The study was
approved by the Institutional Review Board, and all
participants gave written informed consent prior to
enrollment. Diffusion-weighted MR imaging of the lumbar
spine was performed in 39 patients (all men; mean age, 53
years) and five volunteers (all men; mean age, 31 years).
ADC values were recorded for each disk. All disks were
visually graded by two independent observers as being normal
or as showing at least one of three MR findings of
degeneration on sagittal T2-weighted images. Mean ADC values
of normal disks were compared with those of degenerated
disks and were correlated with age and anatomic location.
Data were analyzed by using Kendall correlation statistics,
Mantel-Haenszel statistics, and a paired two-tailed Student
t test. RESULTS: The mean ADC value was 2.27 x 10(-3)
mm(2)/sec +/- 0.58 (+/- standard deviation) in normal disks
and 2.06 x 10(-3) mm(2)/sec +/- 0.47 in abnormal disks (9%
reduction, P = .006). A statistically significant dependence
of lumbar disk ADC on anatomic location was reported
(analysis of variance, P < .001), with lower ADC values seen
in more caudal disks. There was no association between age
and mean disk ADC. CONCLUSIONS: A statistically significant
decrease was seen in the ADC values of degenerated lumbar
disks when compared with ADC values of normal disks. More
caudal disks, even when normal, showed lower ADC values than
more cephalic disks.},
Language = {eng},
Doi = {10.1148/radiol.2352040437},
Key = {fds132187}
}
@article{fds132195,
Author = {JM Provenzale},
Title = {Introduction to the AJR Technology Forum: issues,
controversies & utility of PET/CT imaging.},
Journal = {AJR. American journal of roentgenology},
Volume = {184},
Number = {5 Suppl},
Pages = {Sii},
Year = {2005},
Month = {May},
ISSN = {0361-803X},
url = {http://dx.doi.org/10.2214/ajr.184.5_supplement.01840sii},
Keywords = {Humans • Image Enhancement • Image Interpretation,
Computer-Assisted • Imaging, Three-Dimensional •
Nuclear Medicine • Radiology • Tomography,
Emission-Computed • Tomography, X-Ray Computed •
education • methods* • trends*},
Language = {eng},
Doi = {10.2214/ajr.184.5_supplement.01840sii},
Key = {fds132195}
}
@article{fds132199,
Author = {G York and D Barboriak and J Petrella and D DeLong and JM
Provenzale},
Title = {Association of internal carotid artery injury with carotid
canal fractures in patients with head trauma.},
Journal = {AJR. American journal of roentgenology},
Volume = {184},
Number = {5},
Pages = {1672-8},
Year = {2005},
Month = {May},
ISSN = {0361-803X},
url = {http://dx.doi.org/10.2214/ajr.184.5.01841672},
Keywords = {Adult • Carotid Artery Injuries • Cerebral
Angiography • Chi-Square Distribution •
Craniocerebral Trauma • Female • Humans •
Logistic Models • Male • Middle Aged •
Predictive Value of Tests • Retrospective Studies
• Sensitivity and Specificity • Skull Fractures
• Tomography, X-Ray Computed • Wounds,
Nonpenetrating • radiography*},
Abstract = {OBJECTIVE: The purpose of our study was to determine the
degree to which carotid canal fracture and other CT findings
are associated with internal carotid artery (ICA) injury in
patients with head trauma. METHODS: Three neuroradiologists
retrospectively evaluated CT scans and cerebral angiograms
of 43 patients who underwent cerebral angiography within 7
days after blunt cranial trauma over a 5-year period.
Seventeen patients underwent unilateral and 26 had bilateral
carotid angiography. Angiograms were evaluated for ICA
injury and CT scans were evaluated for carotid canal
fracture, brain contusion, subarachnoid hemorrhage, basilar
skull fracture, subdural hematoma, soft-tissue swelling,
sphenoid sinus air-fluid level, and other skull fracture. We
recorded the number of true-positive (+CT, +angiogram),
true-negative (-CT, -angiogram), false-positive (+CT,
-angiogram), and false-negative (-CT, +angiogram) studies.
We determined the sensitivity, specificity, positive
predictive value, and negative predictive value for each CT
finding. RESULTS: We identified 21 carotid canal fractures
in 17 patients. Eleven ICA injuries were seen in 10
patients. Six patients with ICA injury had a carotid canal
fracture. The presence of a carotid canal fracture had a
sensitivity of 60% and specificity of 67% for detection of
injury to the ICA passing through that canal. These values
were similar to those for other CT findings. CONCLUSIONS:
Sensitivity, specificity, positive predictive value, and
negative predictive value of carotid canal fracture were
only moderately good for determining the presence of ICA
injury and were similar to other CT findings not typically
associated with ICA injury.},
Language = {eng},
Doi = {10.2214/ajr.184.5.01841672},
Key = {fds132199}
}
@article{fds132204,
Author = {ML Escolar, MD Poe and JM Provenzale and KC Richards and J Allison and S
Wood, DA Wenger and D Pietryga and D Wall and M Champagne and R Morse and W
Krivit, J Kurtzberg},
Title = {Transplantation of umbilical-cord blood in babies with
infantile Krabbe's disease.},
Journal = {The New England journal of medicine, United
States},
Volume = {352},
Number = {20},
Pages = {2069-81},
Year = {2005},
Month = {May},
ISSN = {1533-4406},
Keywords = {Brain • Child Development* • Cord Blood Stem Cell
Transplantation* • Disease Progression •
Electroencephalography • Evoked Potentials •
Female • Fetal Blood • Galactosylceramidase •
Graft Survival • Growth • Histocompatibility
Testing • Humans • Infant • Infant Behavior
• Infant, Newborn • Leukodystrophy, Globoid Cell
• Longitudinal Studies • Male • Motor Skills
• Motor Skills Disorders • Neural Conduction
• Survival Analysis • Transplantation Conditioning
• Treatment Outcome • anatomy & histology •
cerebrospinal fluid • etiology • growth &
development • metabolism • mortality •
physiopathology • therapy* • transplantation*},
Abstract = {BACKGROUND: Infantile Krabbe's disease produces progressive
neurologic deterioration and death in early childhood. We
hypothesized that transplantation of umbilical-cord blood
from unrelated donors before the development of symptoms
would favorably alter the natural history of the disease
among newborns in whom the disease was diagnosed because of
a family history. We compared the outcomes among these
newborns with the outcomes among infants who underwent
transplantation after the development of symptoms and with
the outcomes in an untreated cohort of affected children.
METHODS: Eleven asymptomatic newborns (age range, 12 to 44
days) and 14 symptomatic infants (age range, 142 to 352
days) with infantile Krabbe's disease underwent
transplantation of umbilical-cord blood from unrelated
donors after myeloablative chemotherapy. Engraftment,
survival, and neurodevelopmental function were evaluated
longitudinally for four months to six years. RESULTS: The
rates of donor-cell engraftment and survival were 100
percent and 100 percent, respectively, among the
asymptomatic newborns (median follow-up, 3.0 years) and 100
percent and 43 percent, respectively, among the symptomatic
infants (median follow-up, 3.4 years). Surviving patients
showed durable engraftment of donor-derived hematopoietic
cells with restoration of normal blood galactocerebrosidase
levels. Infants who underwent transplantation before the
development of symptoms showed progressive central
myelination and continued gains in developmental skills, and
most had age-appropriate cognitive function and receptive
language skills, but a few had mild-to-moderate delays in
expressive language and mild-to-severe delays in gross motor
function. Children who underwent transplantation after the
onset of symptoms had minimal neurologic improvement.
CONCLUSIONS: Transplantation of umbilical-cord blood from
unrelated donors in newborns with infantile Krabbe's disease
favorably altered the natural history of the disease.
Transplantation in babies after symptoms had developed did
not result in substantive neurologic improvement.},
Key = {fds132204}
}
@article{fds132196,
Author = {JM Provenzale},
Title = {Radiology's role in covering all the bases.},
Journal = {AJR. American journal of roentgenology},
Volume = {184},
Number = {4},
Pages = {1045},
Year = {2005},
Month = {April},
ISSN = {0361-803X},
Keywords = {Baseball* • Humans • Periodicals as Topic* •
Radiology* • Sports Medicine},
Language = {eng},
Key = {fds132196}
}
@article{fds132214,
Author = {KC Lai and JM Provenzale and D Delong and S Mukundan
Jr},
Title = {Assessing patient utilities for varying degrees of low back
pain.},
Journal = {Academic radiology},
Volume = {12},
Number = {4},
Pages = {467-74},
Year = {2005},
Month = {April},
ISSN = {1076-6332},
url = {http://dx.doi.org/10.1016/j.acra.2004.11.031},
Keywords = {Adult • Aged • Female • Health Status
Indicators • Humans • Low Back Pain • Male
• Middle Aged • Pain Measurement • Patient
Compliance • Prospective Studies • Questionnaires
• Severity of Illness Index* • Time Factors •
diagnosis* • utilization*},
Abstract = {OBJECTIVE: We sought to quantify patient preferences for
mild, moderate, and severe low back pain via time-tradeoff
analysis and utility measurement. METHODS: Forty-one
patients being treated for low back pain in a tertiary care
teaching hospital participated in the study. Patients were
asked to decide which of three health states they were
currently experiencing as well as which of the three health
states was the worst experienced during their lifetime. A
time-tradeoff analysis was performed, during which patients
were asked the amount of time in each of the health states
they would exchange for complete resolution of symptoms. We
correlated (1) subjects' current health state with reported
utility and (2) degree of previous low back pain with
results of time-tradeoff measurements. RESULTS: All patients
were willing to trade a greater number of life-years for
resolution of symptoms given a more severe perceived health
state. Utility decreased as severity of back pain scenarios
increased, with an average utility of 0.93 +/- 0.11 for
mild, 0.65 +/- 0.21 for moderate, and 0.18 +/- 0.17 for
severe pain. No significant difference in time-tradeoff
among subjects was identified based upon current health
state on the day of interview. A statistically significant
difference was seen in patients' willingness to trade time
among those who had actually experienced severe pain versus
those who had not. Kendall's correlation revealed that
subjects who had experienced severe back pain exhibited
significantly lower utilities (P < 0.01) compared with
subjects who had never experienced severe pain. CONCLUSIONS:
As expected, patients with severe low back pain were willing
to sacrifice more potential years of life for resolution of
symptoms, suggesting time-tradeoff can accurately reflect
patient utility. 2. However, we found no correlation between
a subject's current health state and reported
utility.},
Language = {eng},
Doi = {10.1016/j.acra.2004.11.031},
Key = {fds132214}
}
@article{fds132208,
Author = {DC Steffens and CF Pieper and HB Bosworth, JR MacFall and JM
Provenzale, ME Payne and BJ Carroll and LK George and KR
Krishnan},
Title = {Biological and social predictors of long-term geriatric
depression outcome.},
Journal = {International psychogeriatrics / IPA},
Volume = {17},
Number = {1},
Pages = {41-56},
Year = {2005},
Month = {March},
ISSN = {1041-6102},
Keywords = {Aged • Aged, 80 and over • Antidepressive Agents
• Brain • Cerebrovascular Circulation •
Cognition Disorders • Cohort Studies • Depressive
Disorder, Major • Electroconvulsive Therapy •
Female • Follow-Up Studies • Humans •
Magnetic Resonance Imaging • Male • Middle Aged
• Neuropsychological Tests • Prospective Studies
• Treatment Outcome • blood supply •
diagnosis • pathology • physiopathology* •
therapeutic use • therapy},
Abstract = {OBJECTIVE: In this study, we examined 204 older depressed
individuals for up to 64 months to determine factors related
to depression outcome. We hypothesized that both presence of
vascular brain lesions seen on baseline magnetic resonance
imaging (MRI) scans and lower baseline social support
measures would be related to worse depression outcome.
METHODS: At study entry, all subjects were at least 59 years
old, had a diagnosis of major depression, and were free of
other major psychiatric illness and primary neurological
illness, including dementia and stroke. Depression was
diagnosed via structured interview and clinical assessment
by a geriatric psychiatrist who completed a Montgomery
Asberg Depression Rating Scale (MADRS) to determine severity
of depression. Subjects provided self-report data on social
support variables and ability to perform basic and
instrumental activities of daily living (ADL, IADL). All
subjects agreed to have a baseline standardized MRI brain
scan. Ratings of severity of hyperintensities were
determined for the periventricular white matter, deep white
matter, and subcortical gray matter by two readers who
decided by consensus. Treatment was provided by
geropsychiatrists following clinical guidelines. Using mixed
models to analyze the data, we determined the effect of a
variety of demographic, social and imaging variables on the
trajectory of MADRS score, the outcome variable of interest.
RESULTS: MADRS scores decreased steadily over time. In a
final HLM model, in which time since entry, a baseline time
indicator, age, gender, education and Mini-mental State
Examination score were controlled, subjective social
support, instrumental ADL impairment, subcortical gray
matter severity, and the interactions of time with social
network and with subcortical gray matter lesions remained
significantly associated with MADRS score. CONCLUSIONS: Both
social and biological factors at baseline are associated
with longitudinal depression severity in geriatric
depression.},
Language = {eng},
Key = {fds132208}
}
@article{fds132189,
Author = {MA Kliewer and DM DeLong and K Freed and CB Jenkins and EK Paulson and JM
Provenzale},
Title = {Peer review at the American Journal of Roentgenology: how
reviewer and manuscript characteristics affected editorial
decisions on 196 major papers.},
Journal = {AJR. American journal of roentgenology, United
States},
Volume = {183},
Number = {6},
Pages = {1545-50},
Year = {2004},
Month = {December},
ISSN = {0361-803X},
Keywords = {Analysis of Variance • Bibliometrics • Logistic
Models • Manuscripts, Medical* • Peer Review,
Research* • Periodicals* • Radiology*},
Abstract = {OBJECTIVE: The objective of this study was to examine the
relative influence of manuscript characteristics and
peer-reviewer attributes in the assessment of manuscripts.
MATERIALS AND METHODS: Over a 6-month period, all major
papers submitted to the American Journal of Roentgenology
(AJR) were entered into a database that recorded manuscript
characteristics, demographic profiles of reviewers, and the
disposition of the manuscript. Manuscript characteristics
included reviewer ratings on five scales (rhetoric,
structure, science, import, and overall recommendation); the
subspecialty class of the paper; the primary imaging
technique; and the country of origin. Demographic profiles
of the reviewers included age, sex, subspecialty, years of
reviewing, academic rank, and practice type. Statistical
analysis included correlation analysis, ordinal logistic
regression, and analysis of variance. RESULTS: A total of
445 reviews of 196 manuscripts were the work of 335
reviewers. Of the 196 submitted manuscripts, 20 (10.2%) were
accepted, 106 (54.1%) were rejected, and 70 (35.7%) were
rejected with the opportunity to resubmit. Regarding
manuscript characteristics, we found that the country of
origin, score on the science scale, and score on the import
scale were statistically significant variables for
predicting the final disposition of a manuscript. Of the
reviewer attributes, we found a statistically significant
association between greater reviewer age and also higher
academic rank with lower scores on the import scale.
Reviewer concordance was higher for structure, science, and
overall scores than on the rhetoric and import scores.
Greater variability in the overall scoring of papers could
be attributed to the reviewer than the manuscript, but both
factors combined explain only 23% of the total variability.
CONCLUSION: At the AJR, manuscript acceptance was most
strongly associated with reviewer scoring of the science and
import of a major paper and also with the country of origin.
Reviewers who were older and of higher academic rank tended
to discount the importance of manuscripts.},
Key = {fds132189}
}
@article{fds132210,
Author = {CD Lascola and AW Song and TA Haystead and DS Warner and K Verleysen and TA
Freed, JM Provenzale},
Title = {Changes in magnetization transfer MRI correlate with
spreading depression-induced astroglial reactivity and
increased protein expression in mice.},
Journal = {AJR. American journal of roentgenology, United
States},
Volume = {183},
Number = {6},
Pages = {1791-7},
Year = {2004},
Month = {December},
ISSN = {0361-803X},
Keywords = {Animals • Cerebral Cortex • Gliosis •
Immunohistochemistry • Magnetic Resonance Imaging
• Male • Mice • Mice, Inbred C57BL •
Proteins • Spreading Cortical Depression •
diagnosis* • metabolism • metabolism* •
methods* • physiology* • physiopathology •
physiopathology*},
Abstract = {OBJECTIVE: Gliosis refers to a range of glial cell
transformations that vary according to specific brain
pathologic states. Disease, however, is not a prerequisite
for gliosis because glial reactivity may also be seen in
regions of increased physiologic activity. Our study tests
the hypothesis that high-field-strength magnetization
transfer MRI is a sensitive technique for detecting
transient glial reactivity after experimental spreading
depression, a relatively benign perturbation unaccompanied
by cell injury. MATERIALS AND METHODS: Unilateral
neocortical spreading depression was elicited in mouse
cerebral hemispheres and confirmed by transcranial blood
flow and extracellular potential measurements. After 3 days,
mice were imaged at 4 T using magnetization transfer
techniques. Astroglial reactivity was determined
immunohistochemically, and protein expression in control and
experimental hemispheres was compared using proteomic
techniques. RESULTS: Sixteen ([mean +/- SD] +/- 3) spreading
depressions (n = 10) were recorded in experimental
hemispheres. Spreading depression was never observed in
control hemispheres. At 3 days, an 8% decrease (p < 0.05, n
= 4) in magnetization transfer signal intensity was measured
in experimental hemispheres, which was associated with a 37%
increase (p < 0.001, n = 4) in the intensity of glial
fibrillary acidic protein staining. Proteomic analysis
performed 3 days after the induction of spreading depression
showed upregulation of at least 56 proteins, including
extracellular and intracellular elements. CONCLUSION:
Magnetization transfer at 4.0-T MRI is a sensitive method
for detecting glial reactivity and changes in protein
expression not associated with cell injury. These results
suggest magnetization transfer MRI techniques may have
potential for detecting glial reactivity in physiologic
processes such as learning and in early disease
states.},
Key = {fds132210}
}
@article{fds132198,
Author = {TM Holmes, JR Petrella and JM Provenzale},
Title = {Distinction between cerebral abscesses and high-grade
neoplasms by dynamic susceptibility contrast perfusion
MRI.},
Journal = {AJR. American journal of roentgenology},
Volume = {183},
Number = {5},
Pages = {1247-52},
Year = {2004},
Month = {November},
ISSN = {0361-803X},
url = {http://dx.doi.org/10.2214/ajr.183.5.1831247},
Keywords = {Adult • Blood Volume • Brain Abscess • Brain
Neoplasms • Cerebrovascular Circulation • Contrast
Media* • Diagnosis, Differential • Female •
Glioma • Humans • Image Processing,
Computer-Assisted • Magnetic Resonance Imaging* •
Male • diagnosis*},
Abstract = {OBJECTIVE: The purpose of the study was to determine whether
dynamic susceptibility contrast perfusion MRI allowed
distinction of cerebral abscesses from cystic high-grade
brain neoplasms. CONCLUSION: In this small preliminary
study, dynamic susceptibility perfusion MRI allowed
distinction of cerebral abscesses from rim-enhancing
high-grade gliomas. Validation of these results using a
prospective large study is warranted.},
Language = {eng},
Doi = {10.2214/ajr.183.5.1831247},
Key = {fds132198}
}
@article{fds132203,
Author = {JM Provenzale and S Gururangan and G Klintworth},
Title = {Trilateral retinoblastoma: clinical and radiologic
progression.},
Journal = {AJR. American journal of roentgenology, United
States},
Volume = {183},
Number = {2},
Pages = {505-11},
Year = {2004},
Month = {August},
ISSN = {0361-803X},
Keywords = {Brain Neoplasms • Child, Preschool • Disease
Progression • Female • Humans • Infant •
Infant, Newborn • Magnetic Resonance Imaging •
Male • Retinal Neoplasms • Retinoblastoma •
Retrospective Studies • Tomography, X-Ray Computed
• diagnosis* • pathology •
radiography},
Abstract = {OBJECTIVE: The purpose of this study was to assess the
clinical and radiologic features of tumor progression in
children with trilateral retinoblastoma. MATERIALS AND
METHODS: Clinical records of eight children with trilateral
retinoblastoma were reviewed for the patient's age at the
time of diagnosis of the ocular tumor, time interval from
diagnosis of ocular retinoblastoma to discovery of the
intracranial tumor, time interval from diagnosis of
retinoblastoma to death, and time interval from diagnosis of
the intracranial tumor to death. CT or MRI studies were
reviewed for the appearance of the primary intracranial
neoplasm, intracranial metastases, and spinal metastases.
RESULTS: The mean age of the patients at diagnosis of
bilateral retinoblastoma was 4.5 months, and the mean age at
diagnosis of the intracranial midline tumor was 26 months.
The mean interval from the time of diagnosis of
retinoblastoma to discovery of the intracranial tumor was
21.5 months. Two children had spinal leptomeningeal
metastases at the time of discovery of the midline
intracranial mass although no intracranial metastases were
seen on imaging. In the other children, intracranial and
spinal leptomeningeal metastases frequently developed within
months of the diagnosis of retinoblastoma despite lack of
progression in the midline intracranial lesion. Six children
died of leptomeningeal spread of tumor. The mean interval
from diagnosis of the ocular tumor to death was 46 months
and from diagnosis of the intracranial tumor to death was 17
months. One child developed metastatic retinoblastoma in the
ulna 10 years after the diagnosis of the intracranial tumor.
CONCLUSION: Children typically died of leptomeningeal tumor
dissemination despite lack of progression in the midline
intracranial mass. Effective treatment of trilateral
retinoblastoma may require close evaluation of these
children for leptomeningeal dissemination.},
Key = {fds132203}
}
@article{fds132206,
Author = {JM Provenzale and P McGraw and P Mhatre and AC Guo and D
Delong},
Title = {Peritumoral brain regions in gliomas and meningiomas:
investigation with isotropic diffusion-weighted MR imaging
and diffusion-tensor MR imaging.},
Journal = {Radiology},
Volume = {232},
Number = {2},
Pages = {451-60},
Year = {2004},
Month = {August},
ISSN = {0033-8419},
url = {http://dx.doi.org/10.1148/radiol.2322030959},
Keywords = {Adult • Anisotropy • Blood-Brain Barrier •
Brain • Brain Edema • Brain Neoplasms •
Diffusion Magnetic Resonance Imaging* • Dominance,
Cerebral • Extracellular Fluid • Female •
Glioma • Humans • Image Enhancement* • Image
Processing, Computer-Assisted* • Male • Meningeal
Neoplasms • Meningioma • Middle Aged •
Neoplasm Invasiveness • Prognosis • Retrospective
Studies • Sensitivity and Specificity • diagnosis*
• metabolism • pathology •
physiology},
Abstract = {OBJECTIVE: To retrospectively measure the diffusion-weighted
(DW) imaging characteristics of peritumoral hyperintense
white matter (WM) and peritumoral normal-appearing WM, as
seen on T2-weighted magnetic resonance (MR) images of
infiltrative high-grade gliomas and meningiomas. METHODS:
Seventeen patients with biopsy-proved glioma and nine
patients with imaging findings consistent with meningioma
and an adjacent hyperintense region on T2-weighted MR images
were examined with DW and diffusion-tensor MR imaging.
Apparent diffusion coefficients (ADCs) were measured on maps
generated from isotropic DW images of enhancing tumor,
hyperintense regions adjacent to enhancing tumor,
normal-appearing WM adjacent to hyperintense regions, and
analogous locations in the contralateral WM corresponding to
these areas. Fractional anisotropy (FA) was measured in
similar locations on maps generated from diffusion-tensor
imaging data. Changes in ADC and FA in each type of tissue
were compared across tumor types by using a two-sample t
test. P <.05 indicated statistical significance. RESULTS:
Mean ADCs in peritumoral hyperintense regions were 1.309 x
10(-3) mm2/sec (mean percentage of 181% of normal WM) for
gliomas and 1.427 x 10(-3) mm2/sec (192% of normal value)
for meningiomas (no significant difference). Mean ADCs in
peritumoral normal-appearing WM were 0.723 x 10(-3) mm2/sec
(106% of normal value) for gliomas and 0.743 x 10(-3)
mm2/sec (102% of normal value) for meningiomas (no
significant difference). Mean FA values in peritumoral
hyperintense regions were 0.178 (43% of normal WM value) for
gliomas and 0.224 (65% of normal value) for meningiomas (P
=.05). Mean FA values for peritumoral normal-appearing WM
were 0.375 (83% of normal value) for gliomas and 0.404 (100%
of normal value) for meningiomas (P =.01). CONCLUSIONS: The
difference in FA decreases in peritumoral normal-appearing
WM between gliomas and meningiomas was significant, and the
difference in FA decreases in peritumoral hyperintense
regions between these tumors approached but did not reach
significance. These findings may indicate a role for
diffusion MR imaging in the detection of tumoral
infiltration that is not visible on conventional MR
images.},
Language = {eng},
Doi = {10.1148/radiol.2322030959},
Key = {fds132206}
}
@article{fds132217,
Author = {SM Kealey and Y Kim and JM Provenzale},
Title = {Redefinition of multiple sclerosis plaque size using
diffusion tensor MRI.},
Journal = {AJR. American journal of roentgenology},
Volume = {183},
Number = {2},
Pages = {497-503},
Year = {2004},
Month = {August},
ISSN = {0361-803X},
url = {http://dx.doi.org/10.2214/ajr.183.2.1830497},
Keywords = {Adult • Aged • Anisotropy • Brain •
Contrast Media • Female • Gadolinium DTPA •
Humans • Magnetic Resonance Imaging • Male •
Middle Aged • Multiple Sclerosis • Retrospective
Studies • diagnostic use • methods* •
pathology*},
Abstract = {OBJECTIVE: We used diffusion tensor MRI to redefine the size
of multiple sclerosis (MS) plaques on fractional anisotropy
(FA) maps. METHODS: Thirty-six white matter (WM) plaques
were identified in 20 patients with MS. Plaque FA was
measured by placing regions of interest (ROIs) on plaques on
diffusion tensor images. We compared FA values in identical
mirror-image ROIs placed on normal-appearing WM in the
contralateral hemisphere. This comparison showed a mean
decrease in FA of 41% in plaques, serving as the threshold
for outlining abnormal regions in normal-appearing WM
surrounding plaques. ROIs were placed around each plaque and
FA values were compared with those in the mirror-image ROIs.
Combined areas of perilesional normal-appearing WM with 40%
or more FA reduction plus plaque were compared with the
areas of abnormality on T2-weighted images using a paired
Student's t test. A p value of 0.05 or less was considered
significant. RESULTS: Mean plaque area was 60 mm(2) (range,
15-103 mm(2)), mean plaque FA was 0.251 (range,
0.133-0.436), and mean FA of contralateral normal-appearing
WM was 0.429 (range, 0.204-0.712). Applying a threshold of
40% FA reduction, mean combined area of abnormal WM
(including plaque seen on T2-weighted sequences) was 87
mm(2) (range, 30-251 mm(2)) or 145% of the mean plaque area
that was seen on T2-weighted images (p < 0.001).
CONCLUSIONS: Using an operator-defined threshold of abnormal
FA values based on plaque anisotropy characteristics, we saw
a statistically significant increase in plaque
size.},
Language = {eng},
Doi = {10.2214/ajr.183.2.1830497},
Key = {fds132217}
}
@article{fds132211,
Author = {WD Taylor, JR MacFall and ME Payne and DR McQuoid and JM Provenzale and DC Steffens and KR Krishnan},
Title = {Late-life depression and microstructural abnormalities in
dorsolateral prefrontal cortex white matter.},
Journal = {The American journal of psychiatry},
Volume = {161},
Number = {7},
Pages = {1293-6},
Year = {2004},
Month = {July},
ISSN = {0002-953X},
Keywords = {Aged • Anisotropy • Comorbidity • Depressive
Disorder, Major • Diffusion Magnetic Resonance Imaging*
• Echo-Planar Imaging • Female • Frontal Lobe
• Functional Laterality • Heart Diseases •
Humans • Hypertension • Image Processing,
Computer-Assisted • Male • Middle Aged •
Neural Pathways • Occipital Lobe • Prefrontal
Cortex • Psychiatric Status Rating Scales •
anatomy & histology • anatomy & histology* •
diagnosis* • epidemiology • metabolism •
physiology},
Abstract = {OBJECTIVE: The purpose of this study was to determine
whether microstructural abnormalities in the white matter of
the dorsolateral prefrontal cortex are associated with
late-life depression. METHODS: Seventeen elderly depressed
subjects were compared with 16 elderly subjects who were not
depressed. Diffusion tensor imaging was used to measure the
fractional anisotropy of the white matter in the
dorsolateral prefrontal cortex's superior and middle frontal
gyri bilaterally and in the left occipital lobe as a control
region. The authors compared results between groups while
controlling for age, sex, and comorbid medical disorders.
RESULTS: Even after controlling for age, sex, hypertension,
and heart disease, the authors found significantly lower
fractional anisotropy values in the right superior frontal
gyrus white matter of depressed patients than comparison
subjects. CONCLUSIONS: Microstructural changes in the white
matter of the right superior frontal gyrus are associated
with late-life depression. Further work is needed to
determine how these changes contribute to depression
outcomes.},
Language = {eng},
Key = {fds132211}
}
@article{fds132193,
Author = {JA Quinn and DA Reardon and AH Friedman and JN Rich and JH Sampson and J
Vredenburgh, S Gururangan and JM Provenzale and A Walker and H
Schweitzer, DD Bigner and S Tourt-Uhlig and JE Herndon 2nd and ML
Affronti, S Jackson and D Allen and K Ziegler and C Bohlin and C Lentz and HS Friedman},
Title = {Phase 1 trial of irinotecan plus BCNU in patients with
progressive or recurrent malignant glioma.},
Journal = {Neuro-oncology},
Volume = {6},
Number = {2},
Pages = {145-53},
Year = {2004},
Month = {April},
ISSN = {1522-8517},
url = {http://dx.doi.org/10.1215/S1152851703000498},
Keywords = {Adult • Aged • Antineoplastic Combined
Chemotherapy Protocols • Astrocytoma •
Camptothecin • Carmustine • Female •
Glioblastoma • Glioma • Humans • Male •
Middle Aged • Neoplasm Recurrence, Local •
Oligodendroglioma • administration & dosage •
administration & dosage* • adverse effects •
adverse effects* • analogs & derivatives* • drug
therapy • drug therapy* • pathology},
Abstract = {Irinotecan is a topoisomerase I inhibitor previously shown
to be active in the treatment of malignant glioma. We now
report the results of a phase 1 trial of irinotecan plus
BCNU, or 1,3-bis(2-chloroethyl)-1-nitrosourea, for patients
with recurrent or progressive MG. Irinotecan dose escalation
occurred independently within 2 strata: patients receiving
enzyme-inducing antiepileptic drugs (EIAEDs) and patients
not receiving EIAEDs. BCNU was administered at a dose of 100
mg/m2 over 1 h every 6 weeks on the same day as the first
irinotecan dose was administered. Irinotecan was
administered intravenously over 90 min once weekly.
Treatment cycles consisted of 4 weekly administrations of
irinotecan followed by a 2-week rest with dose escalation in
cohorts of 3 to 6 patients. Seventy-three patients were
treated, including 49 patients who were on EIAEDs and 24 who
were not on EIAEDs. The maximum tolerated dose for patients
not on EIAEDs was 125 mg/m2. The maximum tolerated dose for
patients on EIAEDs was 225 mg/m2. Dose-limiting toxicity was
evenly distributed among the following organ systems:
pulmonary, gastrointestinal, cardiovascular, neurologic,
infectious, and hematologic, without a clear predominance of
toxicity involving any one organ system. There was no
evidence of increasing incidence of toxicity involving one
organ system as irinotecan dose was escalated. On the basis
of these results, we conclude that the recommended doses of
irinotecan for a phase 2 clinical trial when given in
combination with BCNU (100 mg/m2) are 225 mg/m2 for patients
on EIAEDs and 125 mg/m2 for patients not on
EIAEDs.},
Language = {eng},
Doi = {10.1215/S1152851703000498},
Key = {fds132193}
}
@article{fds132207,
Author = {DA Reardon and JA Quinn and JN Rich and S Gururangan and J Vredenburgh and JH Sampson and JM Provenzale and A Walker and M Badruddoja and S
Tourt-Uhlig, JE Herndon 2nd and JM Dowell and ML Affronti and S
Jackson, D Allen and K Ziegler and S Silverman and C Bohlin and AH
Friedman, DD Bigner and HS Friedman},
Title = {Phase 2 trial of BCNU plus irinotecan in adults with
malignant glioma.},
Journal = {Neuro-oncology},
Volume = {6},
Number = {2},
Pages = {134-44},
Year = {2004},
Month = {April},
ISSN = {1522-8517},
Keywords = {Adult • Aged • Antineoplastic Combined
Chemotherapy Protocols • Astrocytoma •
Camptothecin • Carmustine • Confidence Intervals
• Female • Glioblastoma • Glioma •
Humans • Male • Middle Aged •
Oligodendroglioma • administration & dosage •
administration & dosage* • analogs & derivatives*
• drug therapy • drug therapy* •
pathology},
Abstract = {In preclinical studies, BCNU, or 1,3-bis(2-chloroethyl)-1-nitrosourea,
plus CPT-11 (irinotecan) exhibits schedule-dependent,
synergistic activity against malignant glioma (MG). We
previously established the maximum tolerated dose of CPT-11
when administered for 4 consecutive weeks in combination
with BCNU administered on the first day of each 6-week
cycle. We now report a phase 2 trial of BCNU plus CPT-11 for
patients with MG. In the current study, BCNU (100 mg/m2) was
administered on day 1 of each 6-week cycle. CPT-11 was
administered on days 1, 8, 15, and 22 at 225 mg/m2 for
patients receiving CYP3A1- or CYP3A4-inducing
anticonvulsants and at 125 mg/m2 for those not on these
medications. Newly diagnosed patients received up to 3
cycles before radiotherapy, while recurrent patients
received up to 8 cycles. The primary end point of this study
was radiographic response, while time to progression and
overall survival were also assessed. Seventy-six patients
were treated, including 37 with newly diagnosed tumors and
39 with recurrent disease. Fifty-six had glioblastoma
multiforme, 18 had anaplastic astrocytoma, and 2 had
anaplastic oligodendroglioma. Toxicities (grade > or =3)
included infections (13%), thromboses (12%), diarrhea (10%),
and neutropenia (7%). Interstitial pneumonitis developed in
4 patients. Five newly diagnosed patients (14%; 95% CI,
5%-29%) achieved a radiographic response (1 complete
response and 4 partial responses). Five patients with
recurrent MG also achieved a response (1 complete response
and 4 partial responses; 13%; 95% CI, 4%-27%). More than 40%
of both newly diagnosed and recurrent patients achieved
stable disease. Median time to progression was 11.3 weeks
for recurrent glioblastoma multiforme patients and 16.9
weeks for recurrent anaplastic astrocytoma/ anaplastic
oligodendroglioma patients. We conclude that the activity of
BCNU plus CPT-11 for patients with MG appears comparable to
that of CPT-11 alone and may be more toxic.},
Language = {eng},
Key = {fds132207}
}
@article{fds132202,
Author = {RM Levy and DC Steffens and DR McQuoid and JM Provenzale, JR MacFall and KR Krishnan},
Title = {MRI lesion severity and mortality in geriatric
depression.},
Journal = {The American journal of geriatric psychiatry : official
journal of the American Association for Geriatric
Psychiatry},
Volume = {11},
Number = {6},
Pages = {678-82},
Year = {2004},
Month = {March},
ISSN = {1064-7481},
Keywords = {Aged • Brain • Cerebrovascular Disorders* •
Depression • Female • Follow-Up Studies •
Humans • Magnetic Resonance Imaging* • Male •
complications • complications* • diagnosis •
mortality • pathology*},
Abstract = {OBJECTIVE: The authors correlated magnetic resonance imaging
(MRI) lesion severity and mortality among depressed elderly
patients. METHODS: They examined the association of
mortality and deep white-matter hyperintensity (DWMH),
periventricular hyperintensity (PVH), and subcortical
gray-matter hyperintensity (SGH) ratings in 259 subjects.
RESULTS: DWMH and PVH were significantly associated with
mortality initially, and, in final modeling, DWMH remained
significant. CONCLUSIONS: These findings suggest that there
is a relationship between cerebrovascular disease severity
and mortality among depressed patients. More studies, with
larger sample sizes, comparing depressed patients and
control subjects are needed to further elucidate this
relationship.},
Language = {eng},
Key = {fds132202}
}
@article{fds132200,
Author = {DJ Madden and WL Whiting and SA Huettel and LE White, JR MacFall and JM
Provenzale},
Title = {Diffusion tensor imaging of adult age differences in
cerebral white matter: relation to response
time.},
Journal = {NeuroImage},
Volume = {21},
Number = {3},
Pages = {1174-81},
Year = {2004},
Month = {March},
ISSN = {1053-8119},
url = {http://dx.doi.org/10.1016/j.neuroimage.2003.11.004},
Keywords = {Adult • Aging • Algorithms • Anisotropy
• Brain • Diffusion Magnetic Resonance Imaging
• Female • Humans • Image Interpretation,
Computer-Assisted • Male • Neural Pathways •
Prefrontal Cortex • Psychomotor Performance •
Reaction Time • anatomy & histology • anatomy &
histology* • growth & development* • methods*
• physiology • physiology*},
Abstract = {Diffusion tensor imaging (DTI) measures the displacement of
water molecules across tissue components, thus providing
information regarding the microstructure of cerebral white
matter. Fractional anisotropy (FA), the degree to which
diffusion is directionally dependent, is typically higher
for compact, homogeneous fiber bundles such as the corpus
callosum. Previous DTI studies in adults have demonstrated
an age-related decline in white matter FA, but whether the
relation between FA and behavioral performance varies as a
function of age has not been determined. We investigated
adult age differences in FA, and age-related changes in the
relation between FA and response time (RT), in a visual
target-detection task. The results confirmed that,
independently of age, FA is higher in the corpus callosum
than in other brain regions. We also observed an age-related
decline in FA that did not vary significantly across the
brain regions. For both age groups, a lower level of
integrity of the cerebral white matter (as indexed by FA),
in specific brain regions, was associated with slower
responses in the visual task. An age-related change in this
relation was evident, however, in that the best predictor of
RT for younger adults was FA in the splenium of the corpus
callosum, whereas for older adults the best predictor was FA
in the anterior limb of the internal capsule. This pattern
is consistent with measures of the task-related cortical
activation obtained from these same individuals and suggests
an age-related increase in the attentional control of
responses mediated by corticostriatal or corticothalamic
circuits.},
Language = {eng},
Doi = {10.1016/j.neuroimage.2003.11.004},
Key = {fds132200}
}
@article{fds132190,
Author = {DJ Madden and WL Whiting and JM Provenzale and SA
Huettel},
Title = {Age-related changes in neural activity during visual target
detection measured by fMRI.},
Journal = {Cerebral cortex (New York, N.Y. : 1991)},
Volume = {14},
Number = {2},
Pages = {143-55},
Year = {2004},
Month = {February},
ISSN = {1047-3211},
Keywords = {Adult • Aged • Aging • Analysis of Variance
• Female • Humans • Magnetic Resonance
Imaging • Male • Middle Aged • Neurons •
Photic Stimulation • Prefrontal Cortex • Reaction
Time • Regression Analysis • Visual Perception
• methods* • physiology •
physiology*},
Abstract = {We used functional magnetic resonance imaging (fMRI) of a
visual target detection (oddball) task to investigate age
differences in neural activation for the detection of two
types of infrequent events: visually simple items requiring
a response shift (targets) and visually complex items that
did not entail a response shift (novels). Targets activated
several prefrontal regions (e.g. middle frontal gyrus), as
well as deep gray matter regions (caudate, putamen, thalamus
and insula). Prefrontal activation was similar for younger
and older adults, whereas deep gray matter activation was
relatively greater for the older adults. Novels activated
occipital regions (fusiform and lateral occipital gyri), and
this activation was relatively reduced for older adults. The
changes in behavioral performance across the task conditions
were similar for the two age groups, although the older
adults' responses were slower overall. Regression analyses
of the relation between neural activation and task
performance (response time) indicated that whereas
performance was mediated most directly by prefrontal cortex
for younger adults, older adults' performance was influenced
to a greater extent by deep gray matter structures. Older
adults may place relatively greater emphasis on the
attentional control of response regulation, in compensation
for the age-related decline in visual processing
efficiency.},
Language = {eng},
Key = {fds132190}
}
@article{fds132215,
Author = {KR Krishnan and WD Taylor and DR McQuoid, JR MacFall and ME Payne and JM
Provenzale, DC Steffens},
Title = {Clinical characteristics of magnetic resonance
imaging-defined subcortical ischemic depression.},
Journal = {Biological psychiatry, United States},
Volume = {55},
Number = {4},
Pages = {390-7},
Year = {2004},
Month = {February},
ISSN = {0006-3223},
Keywords = {Age Factors • Age of Onset • Aged • Aged, 80
and over • Antidepressive Agents • Brain Ischemia
• Case-Control Studies • Chi-Square Distribution
• Cognition • Cognition Disorders •
Demography • Depression • Female • Geriatric
Assessment • Humans • Logistic Models •
Longitudinal Studies • Magnetic Resonance Imaging*
• Male • Middle Aged • Psychiatric Status
Rating Scales • Severity of Illness Index •
complications* • diagnosis • diagnosis* •
drug therapy • epidemiology • etiology •
physiology • therapeutic use},
Abstract = {BACKGROUND: There is a substantial body of research
supporting the vascular depression hypothesis of late-life
depression. To update this hypothesis so it incorporates
recent research, we propose that the term subcortical
ischemic vascular depression may be a more accurate
representation of the disease process. We sought to
investigate this diagnosis as a construct by examining
differences between depressed subjects with and without
magnetic resonance imaging defined subcortical ischemic
vascular depression. METHODS: This case-control study
examined 139 depressed elderly subjects. Demographic data,
psychiatric, medical, and family history, depressive
symptomatology, and functional impairment were compared
between groups dichotomized based on neuroimaging findings.
RESULTS: Seventy-five (54%) of the subjects met neuroimaging
criteria for subcortical ischemic vascular depression. Age
was most strongly associated with increased prevalence of
subcortical ischemic vascular depression. Lassitude and a
history of hypertension were also positively associated with
the diagnosis; a family history of mental illness and loss
of libido were negatively associated with the diagnosis.
CONCLUSIONS: These data support that subcortical ischemic
vascular depression may be a specific syndrome from other
types of late-life depression. Further research is needed to
further characterize this disorder, particularly in regards
to cognitive function and treatment implications.},
Key = {fds132215}
}
@article{fds132212,
Author = {JF Norfray and JM Provenzale},
Title = {Alzheimer's disease: neuropathologic findings and recent
advances in imaging.},
Journal = {AJR. American journal of roentgenology, United
States},
Volume = {182},
Number = {1},
Pages = {3-13},
Year = {2004},
Month = {January},
ISSN = {0361-803X},
Keywords = {Alzheimer Disease • Diagnostic Imaging • Humans
• diagnosis* • drug therapy • methods* •
physiopathology},
Key = {fds132212}
}
@article{fds132194,
Author = {JM Provenzale and R Jahan and TP Naidich and AJ Fox},
Title = {Assessment of the patient with hyperacute stroke: imaging
and therapy.},
Journal = {Radiology, United States},
Volume = {229},
Number = {2},
Pages = {347-59},
Year = {2003},
Month = {November},
ISSN = {0033-8419},
Keywords = {Acute Disease • Brain • Brain Ischemia •
Cerebrovascular Accident • Humans • Magnetic
Resonance Imaging • Radiography, Interventional •
Thrombolytic Therapy • Tomography, X-Ray Computed
• diagnosis • diagnosis* • methods •
pathology • radiography • therapy •
therapy*},
Abstract = {Neuroimaging is an important part of the assessment of
patients with hyperacute stroke. As new treatments that may
reverse cerebral ischemia have been developed, the role of
neuroimaging has changed from simply anatomic depiction of
early infarction to identification, by means of physiologic
(rather than simply anatomic) information, of regions that
are at risk for infarction. The goal of such imaging
techniques is to monitor successes and complications of
recently developed treatments such as thrombolysis.},
Key = {fds132194}
}
@article{fds132209,
Author = {WD Taylor and DC Steffens, JR MacFall and DR McQuoid and ME Payne and JM
Provenzale, KR Krishnan},
Title = {White matter hyperintensity progression and late-life
depression outcomes.},
Journal = {Archives of general psychiatry},
Volume = {60},
Number = {11},
Pages = {1090-6},
Year = {2003},
Month = {November},
ISSN = {0003-990X},
url = {http://dx.doi.org/10.1001/archpsyc.60.11.1090},
Keywords = {Aged • Antidepressive Agents • Cerebral Cortex
• Depressive Disorder, Major • Disease Progression
• Dominance, Cerebral • Drug Therapy, Combination
• Female • Humans • Image Enhancement* •
Image Interpretation, Computer-Assisted* • Longitudinal
Studies • Magnetic Resonance Imaging* • Male
• Mathematical Computing • Middle Aged •
Nerve Net • Psychiatric Status Rating Scales •
Treatment Outcome • adverse effects • diagnosis*
• drug therapy • pathology • pathology*
• physiology • psychology • therapeutic
use},
Abstract = {BACKGROUND: White matter hyperintensities (WMHs) are bright
foci seen in the parenchyma of the brain on T2-weighted
cranial magnetic resonance imaging (MRI) scans and are
associated with geriatric depression. Because they are
associated with age, they should increase in number and size
over time. To our knowledge, this is the first longitudinal,
volumetric MRI study of WMHs in depression. OBJECTIVE: To
determine if WMH progression over 2 years influences
depression outcomes. METHODS: Over 2 years, depressed
subjects received antidepressant treatment according to a
naturalistic somatic treatment algorithm designed to offer
the best possible treatment to the individual. After the
treatment period, depressed subjects were dichotomized based
on whether they had reached and sustained remission during
this period. METHODS: One hundred thirty-three subjects aged
60 years or older meeting DSM-IV criteria for major
depressive disorder. METHODS: Cranial MRI was obtained at
baseline and approximately 2 years later. White matter
hyperintensity volume was measured in each hemisphere using
a semiautomated segmentation process. RESULTS: Subjects were
dichotomized based on achieving or not achieving remission
of depressive symptoms, defined as a Montgomery-Asberg
Depression Rating Scale score of 8 or less. RESULTS: The
depressed subgroup that achieved and sustained remission had
significantly less increases in WMH volume (11.5%) than did
the group that did not achieve or sustain remission (31.6%)
(P =.01). In a regression model, greater change in WMH
volume was significantly associated with failure to sustain
remission (P =.004) even when controlling for baseline
depression severity, medical illness severity, age, sex, and
race. Education was associated with achieving and sustaining
remission (P =.02). CONCLUSIONS: Greater progression of WMH
volume is associated with poor outcomes in geriatric
depression. Future work is needed to develop means of
slowing the rate of WMH progression and to determine whether
this will lead to improved depression outcomes in elderly
persons.},
Language = {eng},
Doi = {10.1001/archpsyc.60.11.1090},
Key = {fds132209}
}
@article{fds132220,
Author = {JD Eastwood and MH Lev and M Wintermark and C Fitzek and DP Barboriak and DM Delong and TY Lee and T Azhari and M Herzau and VR Chilukuri and JM
Provenzale},
Title = {Correlation of early dynamic CT perfusion imaging with
whole-brain MR diffusion and perfusion imaging in acute
hemispheric stroke.},
Journal = {AJNR. American journal of neuroradiology, United
States},
Volume = {24},
Number = {9},
Pages = {1869-75},
Year = {2003},
Month = {October},
ISSN = {0195-6108},
Keywords = {Acute Disease • Adult • Aged • Aged, 80 and
over • Blood Flow Velocity • Blood Volume •
Brain • Cerebral Angiography • Cerebrovascular
Accident • Cerebrovascular Circulation* • Contrast
Media • Diffusion Magnetic Resonance Imaging* •
Female • Humans • Magnetic Resonance Angiography*
• Male • Middle Aged • Tomography, X-Ray
Computed* • diagnosis* • pathology •
physiopathology • radiography},
Abstract = {BACKGROUND AND PURPOSE: Compared with MR imaging, dynamic CT
perfusion imaging covers only a fraction of the whole brain.
An important assumption is that CT perfusion abnormalities
correlate with total ischemic volume. The purpose of our
study was to measure the degree of correlation between
abnormalities seen on CT perfusion scans and the volumes of
abnormality seen on MR diffusion and perfusion images in
patients with acute large-vessel stroke. METHODS: Fourteen
patients with acute hemispheric stroke symptoms less than 12
hours in duration were studied with single-slice CT
perfusion imaging and multislice MR diffusion and perfusion
imaging. CT and MR perfusion studies were completed within
2.5 hours of one another (mean, 77 minutes) and were
reviewed independently by two neuroradiologists. Hemodynamic
parameters included cerebral blood flow (CBF), cerebral
blood volume (CBV), and mean transit time (MTT). Extents of
abnormality on images were compared by using Kendall
correlation. RESULTS: Statistically significant correlation
was found between CT-CBF and MR-CBF abnormalities (tau =
0.60, P =.003) and CT-MTT and MR-MTT abnormalities (tau =
0.65, P =.001). Correlation of CT-CBV with MR-CBV approached
significance (tau = 0.39, P =.06). Extent of initial
hyperintensity on diffusion-weighted images correlated best
with extent of MR-CBV abnormality (tau = 0.69, P =.001),
extent of MR-MTT abnormality (tau = 0.67, P =.002), and
extent of CT-CBV abnormality (tau = 0.47, P =.02).
CONCLUSION: Good correlation was seen between CT and MR for
CBF and MTT abnormalities. It remains uncertain whether CT
perfusion CBV abnormalities correspond well to whole-brain
abnormalities.},
Key = {fds132220}
}
@article{fds132186,
Author = {SH Lee and ME Payne and DC Steffens and DR McQuoid and TJ Lai and JM
Provenzale, KR Krishnan},
Title = {Subcortical lesion severity and orbitofrontal cortex volume
in geriatric depression.},
Journal = {Biological psychiatry},
Volume = {54},
Number = {5},
Pages = {529-33},
Year = {2003},
Month = {September},
ISSN = {0006-3223},
Keywords = {Aged • Brain • Depressive Disorder, Major •
Female • Frontal Lobe • Humans • Magnetic
Resonance Imaging • Male • Risk Factors •
pathology • pathology*},
Abstract = {Previous studies have shown a reduction of orbital frontal
cortex volume and an increase in magnetic resonance imaging
signal hyperintensities in geriatric depression. We aimed to
assess the relationship between subcortical gray- and deep
white-matter lesions and orbital frontal cortex volume in
elderly depressives and controls. The study included 41
elderly depressed patients and 41 age-matched control
subjects. The orbital frontal cortex volume was measured in
both hemispheres using a standardized MRI procedure. Signal
hyperintensities were rated on (T2)-weighted MRI with
qualitative lesion analyses performed according to an
established hyperintensity classification system. After
controlling for total cerebral hemisphere, age and sex, the
geriatric depressed subjects had significant reduction in
orbital frontal cortex volume and compared with the control
group. Multiple linear regression modeling indicated that
reduced orbital frontal cortex volumes were significantly
associated with increased subcortical gray-matter lesions.
Our study confirmed the reduction of OFC volume in geriatric
depressed subjects. We also suggest that subcortical lesions
may decrease OFC volume. Further studies are needed to
understand how subcortical lesions may be related to OFC
volume changes.},
Language = {eng},
Key = {fds132186}
}
@article{fds132164,
Author = {WD Taylor, JR MacFall and JM Provenzale and ME Payne and DR McQuoid and DC Steffens and KR Krishnan},
Title = {Serial MR imaging of volumes of hyperintense white matter
lesions in elderly patients: correlation with vascular risk
factors.},
Journal = {AJR. American journal of roentgenology, United
States},
Volume = {181},
Number = {2},
Pages = {571-6},
Year = {2003},
Month = {August},
ISSN = {0361-803X},
Keywords = {Aged • Brain • Continental Population Groups
• Diabetes Mellitus • Female • Humans •
Image Processing, Computer-Assisted • Longitudinal
Studies • Magnetic Resonance Imaging* • Male
• Middle Aged • anatomy & histology*},
Abstract = {OBJECTIVE: The purpose of the study was to examine change in
volume of hyperintense white matter lesions in a cohort of
community-dwelling elderly subjects without neuropsychiatric
disease. SUBJECTS AND METHODS. One hundred seventeen
volunteers underwent brain MR imaging on a 1.5-T scanner.
Demographic data and the presence of specific medical
illnesses were recorded at the time of the initial scanning.
Hyperintense white matter lesion volume was measured using a
supervised semiautomated technique that seeded lesions and
then created a segmented lesion image. Subjects underwent
repeated MR imaging at a mean of 25 months. Mean change in
lesion volume and mean percentage of change were determined
between the two time points. Logistic regression models were
used to examine the differential effects of age, sex, race,
and self-reported medical morbidity. RESULTS: Mean baseline
volume of cerebral hyperintense lesions was 4.91 cc, and at
2-year follow-up, it was 6.42 cm(2) (p < 0.0001), for a mean
increase of 26.7%. Comparable results were seen in separate
analyses of hemispheric hyperintense lesion volumes. Neither
sex, race, nor baseline hyperintense lesion volume was
significantly associated with an interval increase in lesion
volume. Age (p = 0.0117) and presence of diabetes (p =
0.0215) were associated with greater change. CONCLUSION:
Elderly subjects exhibited approximately a 27% increase in
hyperintense lesion volume over a 2-year period, a finding
influenced by both age and medical comorbidity rates.
Because hyperintense lesions can be associated with several
neuropsychiatric conditions, further research is needed to
determine if interventions designed to slow hyperintense
lesion disease progression may improve neuropsychiatric
outcomes.},
Key = {fds132164}
}
@article{fds131967,
Author = {JD Eastwood and JM Provenzale},
Title = {Cerebral blood flow, blood volume, and vascular permeability
of cerebral glioma assessed with dynamic CT perfusion
imaging.},
Journal = {Neuroradiology, Germany},
Volume = {45},
Number = {6},
Pages = {373-6},
Year = {2003},
Month = {June},
ISSN = {0028-3940},
Keywords = {Aged • Blood Volume • Brain Neoplasms •
Capillary Permeability • Cerebral Cortex •
Cerebrovascular Circulation • Glioma • Humans
• Magnetic Resonance Angiography • Male •
Regional Blood Flow • Tomography, X-Ray Computed*
• blood supply • diagnosis* • physiology*
• physiopathology* • radiography*},
Abstract = {We report dynamic CT perfusion imaging assessment of
hemodynamics in a patient with a high-grade cerebral glioma
and compare our results to those of previously published
studies.},
Key = {fds131967}
}
@article{fds132120,
Author = {WD Taylor, JR MacFall and DC Steffens and ME Payne and JM Provenzale and KR Krishnan},
Title = {Localization of age-associated white matter hyperintensities
in late-life depression.},
Journal = {Progress in neuro-psychopharmacology & biological
psychiatry, England},
Volume = {27},
Number = {3},
Pages = {539-44},
Year = {2003},
Month = {May},
ISSN = {0278-5846},
Keywords = {Age Factors • Aged • Aged, 80 and over •
Depressive Disorder, Major • Female • Humans
• Magnetic Resonance Imaging • Male • Middle
Aged • Nerve Fibers, Myelinated • Prefrontal
Cortex • methods • pathology* • psychology
• statistics & numerical data},
Abstract = {OBJECTIVE: Deep white matter hyperintense lesions are
associated with advanced age and late-life depression. The
authors examined where age-related cerebral lesions occurred
in elderly depressed and healthy control subjects. METHODS:
Eighty-seven depressed subjects and 47 control subjects
underwent 1.5 T cranial magnetic resonance imaging (MRI).
Utilizing a semiautomated method, a segmented image was
created containing only white matter lesions. We created a
statistical parametric map (SPM) separately for each subject
group that displayed the association between lesions in any
voxel and advanced age. RESULTS: The SPM analysis in
depressed subjects demonstrates a significant association
between age and lesions found in bilateral, frontal, and
left parietal regions. The analysis in control subjects
found significant associations only in bilateral
parieto-temporal regions, not frontal regions. CONCLUSIONS:
This study demonstrates a different pattern of age-related
lesion location between depressed and control subjects. It
further supports the theory that frontostriatal
disconnection contributes to late-life depression.},
Key = {fds132120}
}
@article{fds132000,
Author = {JD Eastwood and ST Engelter and JF MacFall and DM Delong and JM
Provenzale},
Title = {Quantitative assessment of the time course of infarct signal
intensity on diffusion-weighted images.},
Journal = {AJNR. American journal of neuroradiology},
Volume = {24},
Number = {4},
Pages = {680-7},
Year = {2003},
Month = {April},
ISSN = {0195-6108},
Keywords = {Acute Disease • Aged • Analysis of Variance •
Brain • Cerebral Infarction • Cross-Sectional
Studies • Diffusion Magnetic Resonance Imaging •
Female • Humans • Image Enhancement • Image
Processing, Computer-Assisted • Male •
Mathematical Computing • Middle Aged • Prospective
Studies • Retrospective Studies • Sensitivity and
Specificity • Software • Time Factors •
diagnosis* • methods* • pathology},
Abstract = {OBJECTIVE: Diffusion-weighted (DW) MR imaging is important
in evaluating acute stroke, and knowledge of the signal
intensity changes associated with acute stroke is valuable.
Our purpose was to model the time course of the signal
intensity of infarcts and to characterize the apparent
diffusion coefficient (ADC) and T2 effects on total signal
intensity. METHODS: Ninety-two patients were included in
this prospective cross-sectional study. Signal intensity in
infarcts (4 hours to 417 days) and control regions were
recorded on DW images (b = 0 and 1000 s/mm(2)), ADC maps,
and ratio images (image with b = 1000 s/mm(2) divided by
image with b = 0 s/mm(2)). Cubic spline functions were used
for polynomial fitting. The time courses of log signal
intensity with log time were modeled. The independent
contributions of T2 and ADC to the total signal intensity
were retrospectively compared at 0-63 hours, 3-10 days,
11-57 days, and 57 days onward. RESULTS: Mean signal
intensity on DW images was maximal at 40 hours after
infarction and normalized at 57 days. At 0-63 hours, the
positive effect of ADC on signal intensity was greater than
that of T2 (log value,13 +/- 0.04 vs 0.11 +/- 0.05; P =.04).
At days 3-10, the positive T2 effect predominated (0.13 +/-
0.08 vs 0.08 +/- 0.04; P =.12). At 10-57 days, the positive
T2 effect was greater than the negative ADC effect. After
day 57, the negative ADC effect predominated. CONCLUSIONS:
The signal intensity of infarcts on DW images normalizes at
57 days, which is substantially later than previously
suggested. T2 (shine-through) effect contributes largely to
the total infarct signal intensity.},
Language = {eng},
Key = {fds132000}
}
@article{fds132177,
Author = {WL Whiting and DJ Madden and LK Langley and LL Denny and TG Turkington and JM Provenzale and TC Hawk and RE Coleman},
Title = {Lexical and sublexical components of age-related changes in
neural activation during visual word identification.},
Journal = {Journal of cognitive neuroscience, United
States},
Volume = {15},
Number = {3},
Pages = {475-87},
Year = {2003},
Month = {April},
ISSN = {0898-929X},
Keywords = {Adult • Aged • Aging • Brain Mapping •
Cerebrovascular Circulation • Discrimination
(Psychology)* • Female • Humans • Male •
Middle Aged • Reaction Time • Reading* •
Regional Blood Flow • Tomography, Emission-Computed
• Visual Perception • Vocabulary • physiology
• physiology*},
Abstract = {Positron emission tomography data (Madden, Langley, et al.,
2002) were analyzed to investigate adult age differences in
the relation between neural activation and the lexical (word
frequency) and sublexical (word length) components of visual
word identification. The differential influence of these
components on reaction time (RT) for word/nonword
discrimination (lexical decision) was generally similar for
the two age groups, with word frequency accounting for a
greater proportion of lexical decision RT variance relative
to word length. The influence of word length on RT, however,
was relatively greater for older adults. Activation in
regions of the ventral occipito-temporal cortex was related
to the RT changes associated with word frequency and length
for older adults, but not for younger adults. Specifically,
older adults' frequency effects were related to activation
in both anterior (Brodmann's area [BA] 37) and posterior
(BAs 17 and 18) regions of the occipito-temporal pathway,
whereas word length effects were only associated with
posterior activation (BA 17). We conclude that aging affects
the neural mechanisms supporting word identification
performance although behavioral measures of this ability are
generally constant as a function of age.},
Key = {fds132177}
}
@article{fds132106,
Author = {L Liang and Y Korogi and T Sugahara and I Ikushima and Y Shigematsu and M
Takahashi, JM Provenzale},
Title = {Normal structures in the intracranial dural sinuses:
delineation with 3D contrast-enhanced magnetization prepared
rapid acquisition gradient-echo imaging sequence.},
Journal = {AJNR. American journal of neuroradiology},
Volume = {23},
Number = {10},
Pages = {1739-46},
Year = {2003},
Month = {March},
ISSN = {0195-6108},
Keywords = {Adolescent • Adult • Aged • Aged, 80 and over
• Anatomy, Cross-Sectional • Arachnoid •
Cerebral Veins • Child • Child, Preschool •
Cranial Sinuses • Dura Mater • Echocardiography
• Female • Granulation Tissue • Humans •
Infant • Magnetic Resonance Imaging • Male •
Middle Aged • North Carolina • Prevalence •
Retrospective Studies • Sinus Thrombosis, Intracranial
• diagnosis • epidemiology • pathology •
pathology* • radiography • ultrasonography},
Abstract = {OBJECTIVE: The potential pitfalls in the diagnosis of dural
sinus thrombosis include the presence of arachnoid
granulations, intrasinus fibrotic bands (so-called septa),
and hypoplasia or aplasia of the dural sinuses. The purpose
of this study was to assess the appearance, distribution,
and prevalence of arachnoid granulations and septa in the
dural sinuses by using a high resolution 3D
contrast-enhanced magnetization prepared rapid acquisition
gradient-echo (MPRAGE) imaging sequence. METHODS:
Conventional MR images and contrast-enhanced MPRAGE images
of 100 consecutive patients who had no abnormalities of the
dural sinuses were retrospectively reviewed. The incidence,
site, number, size, signal intensity, and shape of arachnoid
granulations and septa within the sinuses and their
relationship with adjacent veins were recorded. RESULTS:
With 3D contrast-enhanced MPRAGE imaging, 433 round, oval,
or lobulated focal filling defects were found in a total of
90 patients. Curvilinear septa were observed in 92 patients.
Sixty-nine patients had round, oval, or lobulated defects in
the transverse sinus, 59 had such defects in the superior
sagittal sinus, and 47 had such defects in the straight
sinus. All except two of the above defects were isointense
relative to CSF on all images. These structures were
presumed to be arachnoid granulations. Of 431 arachnoid
granulations, 233 (53.8%) were located in the superior
sagittal sinus, 122 (28.1%) in the transverse sinus, and 76
(17.6%) in the straight sinus. One or more veins were seen
to enter arachnoid granulations in 414 (96%) instances.
CONCLUSIONS: The contrast-enhanced 3D MPRAGE imaging
sequence showed a much higher prevalence and a different
distribution of arachnoid granulations and septa within
dural sinuses than have been observed in previous radiologic
studies. Arachnoid granulations were closely related
spatially to veins.},
Language = {eng},
Key = {fds132106}
}
@article{fds132162,
Author = {JA Quinn and DA Reardon and AH Friedman and JN Rich and JH Sampson and JM
Provenzale, RE McLendon and S Gururangan and DD Bigner and JE
Herndon, N Avgeropoulos and J Finlay and S Tourt-Uhlig and ML
Affronti, B Evans and V Stafford-Fox and S Zaknoen and HS
Friedman},
Title = {Phase II trial of temozolomide in patients with progressive
low-grade glioma.},
Journal = {Journal of clinical oncology : official journal of the
American Society of Clinical Oncology, United
States},
Volume = {21},
Number = {4},
Pages = {646-51},
Year = {2003},
Month = {February},
ISSN = {0732-183X},
Keywords = {Adolescent • Adult • Antineoplastic Agents,
Alkylating • Child • Combined Modality Therapy
• Dacarbazine • Disease-Free Survival* •
Female • Glioma • Humans • Male • Middle
Aged • adverse effects • analogs & derivatives*
• drug therapy* • pathology • therapeutic
use*},
Abstract = {PURPOSE: Temozolomide (Temodar; Schering-Plough Corp,
Kenilworth, NJ) is an imidazole tetrazinone that undergoes
chemical conversion to the active methylating agent
5-(3-methyltriazen-1yl)imidazole-4-carboximide under
physiologic conditions. Previous studies have confirmed
activity of Temodar in the treatment of progressive and
newly diagnosed malignant gliomas. We have extended these
results, and now we report results of a phase II trial of
Temodar for patients with progressive, low-grade glioma.
PATIENTS AND METHODS: Temodar was administered orally once a
day for five consecutive days (in a fasting state) at a
starting dose of 200 mg/m(2)/d. Treatment cycles were
repeated every 28 days following the first daily dose of
Temodar. Response criteria used a combination of magnetic
resonance imaging and physical examination to evaluate
activity. RESULTS: Forty-six patients with low-grade glioma
have been treated to date. The objective response rate was
61% (24% complete response and 37% partial response), with
an additional 35% of patients having stable disease. Median
progression-free survival (PFS) was 22 months (95%
confidence interval [CI], 15 to infinity months) with a
6-month PFS of 98% (95% CI, 94% to 100%) and a 12-month PFS
of 76% (95% CI, 63% to 92%). Toxicity observed during the
study was limited to only six patients. Three patients
experienced grade 3 neutropenia, with a duration greater
than 3 weeks in one patient, and two patients experienced
grade 3 thrombocytopenia. One patient experienced > or =
grade 4 toxicity, with intracerebral hemorrhage,
neutropenia, thrombocytopenia, sepsis, and death.
CONCLUSION: Initial results indicate that Temodar may be
active in the treatment of low-grade glioma, and thus,
further evaluation of this agent in the treatment of these
tumors is warranted.},
Key = {fds132162}
}
@article{fds131986,
Author = {EM Rohren and JM Provenzale and DP Barboriak and RE
Coleman},
Title = {Screening for cerebral metastases with FDG PET in patients
undergoing whole-body staging of non-central nervous system
malignancy.},
Journal = {Radiology, United States},
Volume = {226},
Number = {1},
Pages = {181-7},
Year = {2003},
Month = {January},
ISSN = {0033-8419},
Keywords = {Adolescent • Adult • Aged • Aged, 80 and over
• Brain Neoplasms • False Positive Reactions
• Female • Fluorodeoxyglucose F18 • Humans
• Magnetic Resonance Imaging* • Male • Middle
Aged • Neoplasm Staging • Regression Analysis
• Sensitivity and Specificity • Tomography,
Emission-Computed* • diagnostic use* • methods
• pathology • radionuclide imaging* •
secondary*},
Abstract = {PURPOSE: To compare fluorine 18 fluorodeoxyglucose (FDG)
positron emission tomography (PET) with the current
standard, magnetic resonance (MR) imaging, to determine the
sensitivity and specificity of FDG PET for detection of
cerebral metastases and to determine the factors that may
affect lesion conspicuity. MATERIALS AND METHODS: Forty
patients underwent brain PET and contrast material-enhanced
brain MR imaging, with a maximum of 30 days between
examinations. PET and MR images were each retrospectively
reviewed by two independent readers who were blinded to the
clinical history and results of the other technique.
Presence of metastatic disease was recorded for each
modality. Sensitivity and specificity of FDG PET were
determined with MR imaging as the standard. Statistical
analysis was performed with the Fisher exact test and the
logistic regression model. RESULTS: Sixteen patients had
cerebral metastases at MR imaging, and in 12 of these, PET
scans were interpreted as showing metastatic disease (in
four, scans were false-negative). Twenty-four patients had
no cerebral metastases at MR imaging, and 20 of these had
PET scans interpreted as normal (in four, scans were
false-positive). For identification of patients with
cerebral metastases, FDG PET had a sensitivity of 75% (12 of
16) and a specificity of 83% (20 of 24). Thirty-eight
metastatic lesions were seen at MR imaging; 23 (61%) of
these were identified at PET. Size was a statistically
significant factor that influenced lesion detection at PET
(P <.001). CONCLUSION: Only 61% of metastatic lesions in the
brain were identified at PET. In particular, detection of
small lesions was difficult.},
Key = {fds131986}
}
@article{fds132156,
Author = {JD Eastwood and MH Lev and JM Provenzale},
Title = {Perfusion CT with iodinated contrast material.},
Journal = {AJR. American journal of roentgenology, United
States},
Volume = {180},
Number = {1},
Pages = {3-12},
Year = {2003},
Month = {January},
ISSN = {0361-803X},
Keywords = {Acute Disease • Adult • Aged • Blood Volume
• Brain • Cerebral Angiography •
Cerebrovascular Accident • Cerebrovascular Circulation
• Contrast Media* • Female • Humans •
Iodine Compounds • Male • Middle Aged •
Subtraction Technique • Tomography, X-Ray Computed*
• diagnostic use* • methods • radiography
• radionuclide imaging* • therapy},
Key = {fds132156}
}
@article{fds132006,
Author = {ST Engelter and JM Provenzale, JR Petrella and DM DeLong and MJ
Alberts},
Title = {Infarct volume on apparent diffusion coefficient maps
correlates with length of stay and outcome after middle
cerebral artery stroke.},
Journal = {Cerebrovascular diseases (Basel, Switzerland)},
Volume = {15},
Number = {3},
Pages = {188-91},
Year = {2003},
ISSN = {1015-9770},
url = {http://dx.doi.org/10.1159/000068826},
Keywords = {Aged • Brain Mapping • Diffusion • Female
• Glasgow Outcome Scale • Humans •
Infarction, Middle Cerebral Artery • Length of Stay*
• Magnetic Resonance Imaging • Male • Middle
Aged • Observer Variation • Prognosis •
Prospective Studies • Risk Factors • Stroke •
Treatment Outcome • etiology • pathology* •
therapy*},
Abstract = {BACKGROUND: Diffusion-weighted MRI (DWI) can depict acute
ischemia based on decreased apparent diffusion coefficient
(ADC) values. ADC maps, unlike DWI (which have contributions
from T2 properties), solely reflect diffusion properties.
Recent studies indicate that severity of neurological
deficit corresponds with degree of ADC alteration.
OBJECTIVE: To determine whether infarct volume on ADC maps
correlates with length of hospitalization and clinical
outcome in patients with acute ischemic middle cerebral
artery (MCA) stroke. METHODS: Forty-five consecutive
patients with acute (<or=72 h) MCA infarcts seen on DWI.
METHODS: Infarct volume was determined by counting pixels
with ADC values >3 SDs below the average ADC value of a
contralateral control region. Infarct volume was correlated
with length of hospitalization and 6-month outcome assessed
with Glasgow Outcome Scale (GOS), Modified Rankin Score
(mRS), Barthel Index (BI) and a dichotomized outcome status
with favorable outcome defined as GOS 1, mRS <or=1 and BI
>or=95. RESULTS: Infarct volume on ADC maps ranged from 0.2
to 187 cm(3) and was significantly correlated with length of
hospitalization (p < 0.001, r = 0.67). Furthermore, ADC
infarct volume was significantly correlated with GOS (r =
0.73), mRS (r = 0.68), BI (r = 0.67) and outcome status (r =
0.65) (each p < 0.001). Multiple logistic regression
revealed a statistically significant correlation between ADC
infarct volume and outcome status (p < 0.05), but none for
Canadian Neurological Scale score, age and gender (p >0.05
each). CONCLUSIONS: Infarct volume measured by using a
quantitative definition for infarcted tissue on ADC maps
correlated significantly with length of hospitalization (as
a possible surrogate marker for short-term outcome) and
functional outcome after 6 months. ADC infarct volume may
provide prognostic information for patients with acute
ischemic MCA stroke.},
Language = {eng},
Doi = {10.1159/000068826},
Key = {fds132006}
}
@article{fds132116,
Author = {P McGraw and L Liang and JM Provenzale},
Title = {Evaluation of normal age-related changes in anisotropy
during infancy and childhood as shown by diffusion tensor
imaging.},
Journal = {AJR. American journal of roentgenology, United
States},
Volume = {179},
Number = {6},
Pages = {1515-22},
Year = {2002},
Month = {December},
ISSN = {0361-803X},
Keywords = {Anisotropy • Brain • Child, Preschool •
Diffusion Magnetic Resonance Imaging* • Female •
Humans • Infant • Infant, Newborn • Male
• Myelin Sheath • Retrospective Studies •
anatomy & histology* • growth & development •
physiology},
Abstract = {OBJECTIVE: The first purpose of this study was to compare
the degree of anisotropy in compact white matter and
noncompact white matter in each of three pediatric age
groups using diffusion tensor imaging. We hypothesized that
anisotropy would be higher in compact white matter than in
noncompact white matter in each age group. The second
purpose of our study was to compare the increase in
anisotropy over time in compact versus noncompact white
matter during early childhood. We hypothesized that
increases in anisotropy would be higher in noncompact white
matter. MATERIALS AND METHODS: We retrospectively analyzed
anisotropy maps derived from diffusion tensor imaging
studies performed in 66 pediatric patients (age range, 4
days-71 months; mean age, 18.6 months) who underwent
clinical MR imaging and were found to have no abnormalities
on conventional MR images. Anisotropy was measured in three
compact white matter structures (corpus callosum, internal
capsule, cerebral peduncle) and two regions of noncompact
white matter (corona radiata and peripheral white matter).
Patients were assigned to one of the three following groups
on the basis of age: group 1, younger than 12 months (n =
40); group 2, 12-35 months (n = 11); and group 3, 36-71
months (n = 15). First, we compared anisotropy values of
noncompact white matter with those of compact white matter
for each age group. Second, we compared the increase over
time in anisotropy of noncompact white matter regions with
that seen in compact white matter structures. RESULTS: Among
all three age groups, anisotropy measurements in compact
white matter structures were higher than those in noncompact
white matter (p < 0.01). The mean anisotropy values in
noncompact white matter for groups 1, 2, and 3,
respectively, were 0.349, 0.480, and 0.531. The mean
anisotropy values in compact white matter for groups 1, 2,
and 3, respectively, were 0.494, 0.646, and 0.697. When age
groups were compared, a statistically significant increase
in anisotropy was seen in both compact white matter and
noncompact white matter (p < 0.01). However, the increase in
anisotropy was significantly greater in non-compact white
matter regions than in compact white matter structures when
comparing group 1 with group 3 (p < 0.01) as well as group 1
with group 2 (p < 0.01). CONCLUSION: Although anisotropy
measurements were higher in compact than non-compact white
matter in all three age groups, the increase in anisotropy
was greater in non-compact white matter across each of the
three groups. These data suggest that although myelination
is initially greater in compact white matter, the change in
myelination may be greater in noncompact white matter during
the first few years after infancy.},
Key = {fds132116}
}
@article{fds132139,
Author = {ME Payne and DL Fetzer, JR MacFall and JM Provenzale and CE Byrum and KR
Krishnan},
Title = {Development of a semi-automated method for quantification of
MRI gray and white matter lesions in geriatric
subjects.},
Journal = {Psychiatry research},
Volume = {115},
Number = {1-2},
Pages = {63-77},
Year = {2002},
Month = {August},
ISSN = {0165-1781},
Keywords = {Aged • Brain • Brain Diseases • Depressive
Disorder, Major • Female • Humans • Image
Processing, Computer-Assisted* • Magnetic Resonance
Imaging* • Male • Middle Aged •
Reproducibility of Results • diagnosis* •
pathology • psychology},
Abstract = {Brain magnetic resonance imaging (MRI) allows for
quantitative assessment of hyperintense foci, which are seen
with aging and various diseases. These foci, considered to
represent lesions, are important in the study of various
psychiatric illnesses, including depression. Few
quantitative measures have been developed for such research.
The goal of the current study was to develop a reliable and
efficient method for quantifying the volumes of gray and
white matter lesions in MRI scans of the elderly. Interrater
reliability was determined by repeat lesion measures on 16
scans. Semi-automated segmentation was performed that
identified potential lesions, and then lesions were manually
selected based upon detailed anatomic criteria. The lesion
quantification procedure took between 25 and 45 min per
scan. Reliability intraclass correlation coefficients (ICCs)
were 0.99 for both gray and white matter lesions. Volumetric
results were found to be moderately correlated with previous
lesion ratings (r-values between 0.37 and 0.62, P<0.0001).
Among the 700 scans processed with this method, lesion
volumes ranged from 0 to 7.3 ml for gray matter, and from
0.4 to 96.8 ml for white matter. Our method proved to be
efficient and reliable for quantifying lesions in MRI scans
of the elderly.},
Language = {eng},
Key = {fds132139}
}
@article{fds131968,
Author = {EP Ahearn and MC Speer and YT Chen and DC Steffens and F Cassidy and S Van
Meter and JM Provenzale and RH Weisler and KR Krishnan},
Title = {Investigation of Notch3 as a candidate gene for bipolar
disorder using brain hyperintensities as an
endophenotype.},
Journal = {American journal of medical genetics},
Volume = {114},
Number = {6},
Pages = {652-8},
Year = {2002},
Month = {August},
ISSN = {0148-7299},
url = {http://dx.doi.org/10.1002/ajmg.10512},
Keywords = {Adolescent • Adult • Age of Onset • Aged
• Bipolar Disorder • Brain • Female •
Genetic Linkage • Humans • Lod Score •
Magnetic Resonance Imaging • Male • Middle Aged
• Models, Genetic • Pedigree • Polymorphism,
Single-Stranded Conformational • Proto-Oncogene
Proteins • Receptors, Cell Surface* • Receptors,
Notch • diagnosis • genetics* •
pathology*},
Abstract = {The purpose of the study was to consider MRI
hyperintensities as a potential endophenotype for bipolar
disorder (BPD) and to investigate Notch3 (CADASIL) as a
candidate gene for BPD. MRI scans were performed on 21
members of a family with a high incidence of BPD. Two-point
and multipoint linkage analyses were performed and two exons
of Notch3 were investigated with SSCP. Fifteen of 21 family
members had MRI hyperintensities, including all bipolar
patients and six family members with no affective illness.
Two-point linkage analysis yielded negative results for all
models. Multipoint linkage analysis yielded negative results
except for Model 1a, in which a maximal LOD score was -1.24.
A mutation screen of Exons 3 and 4 was negative. Notch3 does
not appear to be a candidate gene for BPD in this
family.},
Language = {eng},
Doi = {10.1002/ajmg.10512},
Key = {fds131968}
}
@article{fds132137,
Author = {DJ Madden and LK Langley and LL Denny and TG Turkington and JM
Provenzale, TC Hawk and RE Coleman},
Title = {Adult age differences in visual word identification:
functional neuroanatomy by positron emission
tomography.},
Journal = {Brain and cognition},
Volume = {49},
Number = {3},
Pages = {297-321},
Year = {2002},
Month = {August},
ISSN = {0278-2626},
Keywords = {Adult • Age Factors • Aged • Aging •
Brain • Cerebrovascular Circulation • Cognition
Disorders • Female • Functional Laterality •
Humans • Male • Middle Aged • Reaction Time
• Semantics • Tomography, Emission-Computed*
• Visual Perception • Vocabulary • anatomy &
histology* • blood supply • diagnosis •
epidemiology • metabolism* • physiology •
physiology*},
Abstract = {Adult age differences in the neural systems mediating
semantic (context-independent) memory were investigated
using positron emission tomography (PET). Younger (20-29
years) and older (62-70 years) participants performed
lexical decision (word/nonword discrimination) and
nonsemantic (simple visual search) baseline tasks during PET
scanning. Within the lexical decision task, display duration
and presentation rate were varied across scans. The
behavioral data suggested that although an age-related
slowing was evident in visual feature and response
processing, the retrieval of semantic/lexical information
was similar for younger and older adults. For both age
groups, lexical-related activation occurred in inferior
prefrontal and occipitotemporal regions of the left
hemisphere. Differential activation, as a function of age
group, was observed in the left occipitotemporal pathway as
a result of older adults' maintaining higher levels of
neural activity in striate cortex (during visual search) and
in inferior temporal cortex (during lexical decision). The
prefrontal activation was similar for the two age groups.
Thus, although this form of semantic memory retrieval does
not undergo significant age-related decline, an age-related
change in the associated pattern of neural activation is
evident. These findings differ from previous neuroimaging
studies of episodic (context-dependent) memory retrieval,
which have suggested that age-related compensatory
mechanisms are expressed primarily by greater activation of
prefrontal regions for older adults than for younger
adults.},
Language = {eng},
Key = {fds132137}
}
@article{fds132004,
Author = {AC Guo and TJ Cummings and RC Dash and JM Provenzale},
Title = {Lymphomas and high-grade astrocytomas: comparison of water
diffusibility and histologic characteristics.},
Journal = {Radiology, United States},
Volume = {224},
Number = {1},
Pages = {177-83},
Year = {2002},
Month = {July},
ISSN = {0033-8419},
Keywords = {Adult • Aged • Astrocytoma* • Brain
Neoplasms* • Diffusion • Echo-Planar Imaging*
• Female • Humans • Lymphoma* • Male
• Middle Aged • Water • metabolism •
pathology},
Abstract = {PURPOSE: To determine if water diffusivity within lymphomas
and high-grade astrocytomas correlates with cellularity.
MATERIALS AND METHODS: Echo-planar diffusion-weighted
magnetic resonance (MR) images obtained in 11 patients with
brain lymphomas (19 lesions) and in 17 patients with
astrocytomas (19 lesions) were retrospectively reviewed.
Regions of interest were drawn on apparent diffusion
coefficient (ADC) maps in enhancing tumor. ADC values were
normalized by dividing ADC values of tumors by those of
normal-appearing regions and expressing the quotient as a
ratio. Histologic samples from 11 patients with astrocytomas
(11 lesions) and seven patients with lymphoma (seven
lesions) were reviewed. Cellularity was measured by
calculating the percentage of nuclear area and the
percentage of cytoplasmic area and expressing the results as
the nuclear-to-cytoplasmic (N/C) ratio. The ADC and N/C
ratios of both tumor types were compared by using a
two-tailed t test. RESULTS: Mean ADC ratio of lymphomas was
1.15 (SD, 0.33; standard error of the mean [SEM], 0.10), and
that of high-grade astrocytomas was 1.68 (SD, 0.48; SEM,
0.11) (P <.01). Mean N/C ratio of lymphoma was 1.45 (SD,
0.94; SEM, 0.36), and that of high-grade astrocytomas was
0.24 (SD, 0.18; SEM, 0.05) (P <.01). CONCLUSION:
Measurements of water diffusivity and cellularity suggest
that higher cellularity contributes to more restricted
diffusion.},
Key = {fds132004}
}
@article{fds132148,
Author = {DP Barboriak and JM Provenzale},
Title = {Evaluation of software for registration of contrast-enhanced
brain MR images in patients with glioblastoma
multiforme.},
Journal = {AJR. American journal of roentgenology, United
States},
Volume = {179},
Number = {1},
Pages = {245-50},
Year = {2002},
Month = {July},
ISSN = {0361-803X},
Keywords = {Adult • Aged • Automatic Data Processing •
Brain • Brain Neoplasms • Contrast Media* •
Female • Glioblastoma • Humans • Imaging,
Three-Dimensional • Magnetic Resonance Imaging* •
Male • Middle Aged • Registries* •
Reproducibility of Results • Software Validation*
• pathology*},
Abstract = {OBJECTIVE: We evaluated commercially available software that
rapidly and automatically registers brain MR images on a
clinical workstation, and we studied the accuracy of these
registrations. SUBJECTS AND METHODS: Ten patients with a
diagnosis of glioblastoma multiforme underwent
contrast-enhanced inversion recovery prepared
three-dimensional (3D) volumetric spoiled gradient-recalled
acquisition in the steady state (SPGR) MR imaging
(contiguous 1.5-mm slice thickness, 96-104 slices). After
this imaging sequence, each patient was brought out of the
head coil into a sitting position and then repositioned in
the coil. The inversion recovery prepared 3D SPGR sequence
was then repeated. A commercially available software program
operating on a clinical workstation was used to
automatically register the second inversion recovery
prepared SPGR series to the first. The speed of registration
was recorded. The accuracy of each registration was
estimated by recording the coordinates of eight anatomic
landmarks on the registered and reference series and by
calculating the mean error among matching landmarks.
RESULTS: In nine of 10 patients, the registration software
produced a visually satisfactory registration. In one
patient, a second registration was necessary to produce a
satisfactory registration. The processing time for each
iteration was 48.3 +/- 3.8 sec (mean +/- SD). The mean error
in aligning matching anatomic landmarks ranged from 0.67 to
1.41 mm, with an overall mean of 1.18 mm. The largest error
among matching landmarks was 2.3 mm. CONCLUSION:
Commercially available registration software can
automatically register 3D imaging volumes in less than 1
min. The mean error in registration was approximately
equivalent to the dimensions of a single
voxel.},
Key = {fds132148}
}
@article{fds132169,
Author = {JA Quinn and J Pluda and ME Dolan and S Delaney and R Kaplan and JN Rich and AH Friedman and DA Reardon and JH Sampson and OM Colvin and MM Haglund and AE Pegg and RC Moschel and RE McLendon and JM Provenzale and S
Gururangan, S Tourt-Uhlig and JE Herndon and DD Bigner and HS
Friedman},
Title = {Phase II trial of carmustine plus O(6)-benzylguanine for
patients with nitrosourea-resistant recurrent or progressive
malignant glioma.},
Journal = {Journal of clinical oncology : official journal of the
American Society of Clinical Oncology, United
States},
Volume = {20},
Number = {9},
Pages = {2277-83},
Year = {2002},
Month = {May},
ISSN = {0732-183X},
Keywords = {Adult • Aged • Antineoplastic Combined
Chemotherapy Protocols • Area Under Curve • Brain
Neoplasms • Carmustine • Dose-Response
Relationship, Drug • Drug Administration Schedule
• Drug Resistance, Neoplasm • Female • Glioma
• Guanine • Humans • Male • Middle Aged
• Nitrosourea Compounds • Treatment Outcome •
administration & dosage* • analogs & derivatives*
• drug therapy* • pharmacokinetics •
pharmacology • therapeutic use*},
Abstract = {PURPOSE: We conducted a phase II trial of carmustine (BCNU)
plus the O(6)-alkylguanine-DNA alkyltransferase inhibitor
O(6)-benzylguanine (O(6)-BG) to define the activity and
toxicity of this regimen in the treatment of adults with
progressive or recurrent malignant glioma resistant to
nitrosoureas. PATIENTS AND METHODS: Patients were treated
with O(6)-BG at an intravenous dose of 120 mg/m(2) followed
1 hour later by 40 mg/m(2) of BCNU, with cycles repeated at
6-week intervals. RESULTS: Eighteen patients were treated
(15 with glioblastoma multiforme, two with anaplastic
astrocytoma, and one with malignant glioma). None of the 18
patients demonstrated a partial or complete response. Two
patients exhibited stable disease for 12 weeks before their
tumors progressed. Three patients demonstrated stable
disease for 6, 12, and 18 weeks before discontinuing therapy
because of hematopoietic toxicity. Twelve patients
experienced reversible > or = grade 3 hematopoietic
toxicity. There was no difference in half-lives (0.56 +/-
0.21 hour v 0.54 +/- 0.20 hour) or area under the curve
values (4.8 +/- 1.7 microg/mL/h v 5.0 +/- 1.3 microg/mL/h)
of O(6)-BG for patients receiving phenytoin and those not
treated with this drug. CONCLUSION: These results indicate
that O(6)-BG plus BCNU at the dose schedule used in this
trial is unsuccessful in producing tumor regression in
patients with nitrosourea-resistant malignant glioma,
although stable disease was seen in five patients for 6, 12,
12, 12, and 18 weeks. Future use of this approach will
require strategies to minimize dose-limiting toxicity of
BCNU such as regional delivery or hematopoietic stem-cell
protection.},
Key = {fds132169}
}
@article{fds131972,
Author = {AC Guo, JR MacFall and JM Provenzale},
Title = {Multiple sclerosis: diffusion tensor MR imaging for
evaluation of normal-appearing white matter.},
Journal = {Radiology, United States},
Volume = {222},
Number = {3},
Pages = {729-36},
Year = {2002},
Month = {March},
ISSN = {0033-8419},
Keywords = {Adolescent • Adult • Anisotropy • Brain
• Female • Humans • Magnetic Resonance
Imaging* • Male • Middle Aged • Multiple
Sclerosis • diagnosis • pathology*},
Abstract = {PURPOSE: To determine whether the normal-appearing white
matter (NAWM) regions surrounding and remote from multiple
sclerosis (MS) plaques have abnormal diffusional anisotropy
and to compare anisotropy maps with apparent diffusion
coefficient (ADC) maps for sensitivity in the detection of
white matter (WM) abnormalities. MATERIALS AND METHODS:
Conventional and diffusion tensor magnetic resonance (MR)
imaging examinations were performed in 26 patients with MS
and in 26 age-matched control subjects. Fractional
anisotropy (FA) and ADC maps were generated and coregistered
with T2-weighted MR images. Uniform regions of interest were
placed on plaques, periplaque white matter (PWM) regions,
NAWM regions in the contralateral side of the brain, and WM
regions in control subjects to obtain FA and ADC values,
which were compared across the WM regions. RESULTS: The mean
FA was 0.280 for plaques, 0.383 for PWM, 0.493 for NAWM, and
0.537 for control subject WM. The mean ADC was 1.025 x
10(-3) mm(2)/sec for plaques, 0.786 x 10(-3) mm(2)/sec for
PWM, 0.739 x 10(-3) mm(2)/sec for NAWM, and 0.726 x 10(-3)
mm(2)/sec for control subject WM. Significant differences in
anisotropy and ADC values were observed among all WM regions
(P <.001 for all comparisons, except ADC in NAWM vs control
subject WM [P =.018]). CONCLUSION: The anisotropy and ADC
values were abnormal in all WM regions in the patients with
MS and were worse in the periplaque regions than in the
distant regions. Diffusion tensor MR imaging may be more
accurate than T2-weighted MR imaging for assessment of
disease burden.},
Key = {fds131972}
}
@article{fds131990,
Author = {JM Provenzale and GR Wang and T Brenner, JR Petrella and AG
Sorensen},
Title = {Comparison of permeability in high-grade and low-grade brain
tumors using dynamic susceptibility contrast MR
imaging.},
Journal = {AJR. American journal of roentgenology},
Volume = {178},
Number = {3},
Pages = {711-6},
Year = {2002},
Month = {March},
ISSN = {0361-803X},
Keywords = {Adult • Aged • Brain Neoplasms • Capillary
Permeability* • Contrast Media* • Gadolinium DTPA
• Glioma • Humans • Image Processing,
Computer-Assisted • Magnetic Resonance Imaging* •
Middle Aged • Retrospective Studies • Thalamus
• blood supply • blood supply* • diagnosis
• diagnostic use • methods •
pathology},
Abstract = {OBJECTIVE: The purpose of this study was to compare
permeability measurements in high-grade and low-grade glial
neoplasms using a T2(*)-weighted method. Our hypothesis was
that permeability measurements using a T2(*)-weighted
technique would show permeability in high-grade neoplasms to
be higher than that in low-grade neoplasms. METHODS: Twelve
patients with biopsy-proven high-grade neoplasms and 10
patients with biopsy-proven low-grade neoplasms underwent
dynamic susceptibility contrast MR perfusion imaging (TR/TE,
1500/80) after bolus infusion of 0.2 mmol/kg of MR contrast
material. Color-coded permeability-weighted maps were
created using a model that weights relative contributions to
signal intensity from intravascular T2(*) effects and
extravascular T1 effects from blood-brain barrier
permeability. Two measures of permeability were performed:
mean value of highest permeability found on three images
through the tumor (mean regional value) and highest value
found at any region of interest in the tumor (single area of
maximum permeability). Depending on the normality of the
data sets, we used the Wilcoxon's rank sum test or the
two-tailed Student's t test for statistical analysis.
RESULTS: For low-grade tumors, the range was 0.006-0.041,
and the median of the mean regional value for each image was
0.017. For high-grade tumors, the range was 0.005-0.092, and
the median of the mean regional value was 0.035 (p = 0.025).
For low-grade tumors, the range was 0.008-0.045, and the
mean of the single area of maximum values was 0.02. For
high-grade tumors, the range was 0.007-0.136, and the mean
of the single area of maximum values was 0.054 (p = 0.018).
CONCLUSIONS: Permeability values for high-grade tumors
obtained using a T2(*)-weighted method were significantly
greater than those for low-grade tumors and are consistent
with previous studies reporting results using T1-weighted
methods.},
Language = {eng},
Key = {fds131990}
}
@article{fds132112,
Author = {JD Eastwood and RT Vollmer and JM Provenzale},
Title = {Diffusion-weighted imaging in a patient with vertebral and
epidural abscesses.},
Journal = {AJNR. American journal of neuroradiology},
Volume = {23},
Number = {3},
Pages = {496-8},
Year = {2002},
Month = {March},
ISSN = {0195-6108},
Keywords = {Aged • Aged, 80 and over • Epidural Abscess •
Humans • Lumbar Vertebrae • Magnetic Resonance
Imaging • Male • Spinal Canal • diagnosis*
• methods • pathology • pathology*},
Abstract = {In this report, we describe the appearance of the spinal
vertebral body and epidural abscesses in a patient who
underwent diffusion-weighted imaging of the spine and
CT-guided aspiration of one of the abscesses. The abscesses
were hyperintense relative to the surrounding tissues on
diffusion-weighted images, and they appeared dark on
apparent diffusion coefficient maps; these findings were
consistent with those of published reports of the brain and
liver.},
Language = {eng},
Key = {fds132112}
}
@article{fds132149,
Author = {DJ Madden and TG Turkington and JM Provenzale and LL Denny and LK
Langley, TC Hawk and RE Coleman},
Title = {Aging and attentional guidance during visual search:
functional neuroanatomy by positron emission
tomography.},
Journal = {Psychology and aging},
Volume = {17},
Number = {1},
Pages = {24-43},
Year = {2002},
Month = {March},
ISSN = {0882-7974},
Keywords = {Adult • Aged • Aging • Attention • Brain
Mapping • Cerebral Cortex • Color Perception
• Discrimination Learning • Female • Humans
• Male • Middle Aged • Occipital Lobe •
Orientation • Pattern Recognition, Visual •
Reference Values • Temporal Lobe • Tomography,
Emission-Computed* • Visual Pathways • physiology
• physiology* • radionuclide imaging},
Abstract = {Positron emission tomography (PET) was used to examine adult
age differences in neural activation during visual search.
Target detection was less accurate for older adults than for
younger adults, but both age groups were successful in using
color to guide attention to a subset of display items.
Increasing perceptual difficulty led to greater activation
of occipitotemporal cortex for younger adults than for older
adults, apparently as the result of older adults maintaining
higher levels of activation within the easier task
conditions. The results suggest that compensation for
age-related decline in the efficiency of occipitotemporal
cortical functioning was implemented by changes in the
relative level of activation within this visual processing
pathway, rather than by the recruitment of other cortical
regions.},
Language = {eng},
Key = {fds132149}
}
@article{fds132181,
Author = {DA Reardon and G Akabani and RE Coleman and AH Friedman and HS Friedman and JE Herndon 2nd and I Cokgor and RE McLendon and CN Pegram and JM
Provenzale, JA Quinn and JN Rich and LV Regalado and JH Sampson and TD
Shafman, CJ Wikstrand and TZ Wong and XG Zhao and MR Zalutsky and DD
Bigner},
Title = {Phase II trial of murine (131)I-labeled antitenascin
monoclonal antibody 81C6 administered into surgically
created resection cavities of patients with newly diagnosed
malignant gliomas.},
Journal = {Journal of clinical oncology : official journal of the
American Society of Clinical Oncology},
Volume = {20},
Number = {5},
Pages = {1389-97},
Year = {2002},
Month = {March},
ISSN = {0732-183X},
Keywords = {Adult • Aged • Antibodies • Antibodies,
Monoclonal • Astrocytoma • Brain Neoplasms •
Combined Modality Therapy • Female • Glioblastoma
• Glioma • Humans • Immunotherapy •
Iodine Radioisotopes • Male • Middle Aged •
Oligodendroglioma • Survival Rate • Tenascin
• Treatment Outcome • administration & dosage*
• adverse effects • analysis • diagnostic use
• immunology* • mortality • therapy •
therapy*},
Abstract = {OBJECTIVE: To assess the efficacy and toxicity of
intraresection cavity (131)I-labeled murine antitenascin
monoclonal antibody 81C6 and determine its true response
rate among patients with newly diagnosed malignant glioma.
METHODS: In this phase II trial, 120 mCi of (131)I-labeled
murine 81C6 was injected directly into the surgically
created resection cavity of 33 patients with previously
untreated malignant glioma (glioblastoma multiforme [GBM], n
= 27; anaplastic astrocytoma, n = 4; anaplastic
oligodendroglioma, n = 2). Patients then received
conventional external-beam radiotherapy followed by a year
of alkylator-based chemotherapy. RESULTS: Median survival
for all patients and those with GBM was 86.7 and 79.4 weeks,
respectively. Eleven patients remain alive at a median
follow-up of 93 weeks (range, 49 to 220 weeks). Nine
patients (27%) developed reversible hematologic toxicity,
and histologically confirmed, treatment-related neurologic
toxicity occurred in five patients (15%). One patient (3%)
required reoperation for radionecrosis. CONCLUSIONS: Median
survival achieved with (131)I-labeled 81C6 exceeds that of
historical controls treated with conventional radiotherapy
and chemotherapy, even after accounting for established
prognostic factors including age and Karnofsky performance
status. The median survival achieved with (131)I-labeled
81C6 compares favorably with either (125)I interstitial
brachy-therapy or stereotactic radiosurgery and is
associated with a significantly lower rate of reoperation
for radionecrosis. Our results confirm the efficacy of
(131)I-labeled 81C6 for patients with newly diagnosed
malignant glioma and suggest that a randomized phase III
study is indicated.},
Language = {eng},
Key = {fds132181}
}
@article{fds132107,
Author = {JD Eastwood and MJ Alexander, JR Petrella and JM
Provenzale},
Title = {Dynamic CT perfusion imaging with acetazolamide challenge
for the preprocedural evaluation of a patient with
symptomatic middle cerebral artery occlusive
disease.},
Journal = {AJNR. American journal of neuroradiology, United
States},
Volume = {23},
Number = {2},
Pages = {285-7},
Year = {2002},
Month = {February},
ISSN = {0195-6108},
Keywords = {Acetazolamide • Angiography, Digital Subtraction •
Arterial Occlusive Diseases • Cerebral Angiography
• Cerebral Arteries* • Cerebrovascular Circulation
• Humans • Male • Middle Aged •
Tomography, X-Ray Computed* • diagnostic use* •
physiopathology • radiography*},
Abstract = {We describe the use of a CT-based method of cerebral
perfusion imaging, dynamic CT perfusion imaging, for the
pre- and postprocedural assessment of cerebral blood flow in
a patient with symptomatic middle cerebral artery occlusive
disease who underwent balloon angioplasty with stent
placement in the affected artery. Dynamic CT perfusion
imaging represents a widely available and minimally invasive
alternative to other available methods of cerebral perfusion
imaging.},
Key = {fds132107}
}
@article{fds132150,
Author = {JM Hinman and JM Provenzale},
Title = {Hypointense thrombus on T2-weighted MR imaging: a potential
pitfall in the diagnosis of dural sinus thrombosis.},
Journal = {European journal of radiology},
Volume = {41},
Number = {2},
Pages = {147-52},
Year = {2002},
Month = {February},
ISSN = {0720-048X},
Keywords = {Adolescent • Adult • Brain • Child •
Child, Preschool • Cranial Sinuses • Diagnosis,
Differential • Female • Headache • Humans
• Infant • Magnetic Resonance Imaging* • Male
• Retrospective Studies • Sinus Thrombosis,
Intracranial • complications • diagnosis* •
etiology • pathology • pathology*},
Abstract = {Purpose: To determine the frequency of hypointense
appearance of dural sinus thrombosis on T2-weighted images,
which may mimic a normal flow void, and when possible
correlate with appearance on T1-weighted images. Methods and
Materials: Retrospective review of radiology files showed 51
patients with a discharge diagnosis of dural sinus
thrombosis who underwent MR imaging during the period
1986-1998. These images were reviewed by an experienced
neuroradiologist for appearance on T2-weighted images. This
process yielded five cases in which a hypointense appearance
on this pulse sequence simulated a normal flow void. An
additional two cases were added from the teaching files of
two other institutions giving a total of seven cases (13% of
studies). The resulting study population consisted of five
women and two men (mean age 27.1 years). T1 weighted images
were available in five patients. In two patients MR
venography was available, but not T1-weighted images. The
diagnosis of dural sinus thrombosis was based solely on
absence of flow void on T1-weighted images in one case,
solely on absence of flow void on MR venography in two cases
and absence of flow void on T1-weighted images in
conjunction with MR venography or gradient echo findings in
4 patients. All images were obtained on a 1.5 T magnet (GE
Medical Systems; Milwaukee, Wisconsin). Results: In all
patients hypointense signal of thrombus was isointense with
normal flow voids in other dural sinuses on T2-weighted
images. In all cases in which T1-weighted images were
available, the signal intensity of thrombus was isointense
to gray matter. Conclusion: Hypointense appearance of
thrombus on T2-weighted images is a potential pitfall in the
MR diagnosis of dural sinus thrombosis. Because thrombus in
this stage of evolution appears isointense to gray matter on
T1-weighted images, careful attention must be paid to other
sequences to avoid this pitfall.},
Language = {eng},
Key = {fds132150}
}
@article{fds132140,
Author = {JD Eastwood and MH Lev and T Azhari and TY Lee and DP Barboriak and DM
Delong, C Fitzek and M Herzau and M Wintermark and R Meuli and D
Brazier, JM Provenzale},
Title = {CT perfusion scanning with deconvolution analysis: pilot
study in patients with acute middle cerebral artery
stroke.},
Journal = {Radiology, United States},
Volume = {222},
Number = {1},
Pages = {227-36},
Year = {2002},
Month = {January},
ISSN = {0033-8419},
Keywords = {Adult • Aged • Aged, 80 and over •
Angiography • Brain • Cerebrovascular Accident
• Cerebrovascular Circulation • Female •
Hemodynamic Processes • Humans • Male •
Middle Aged • Pilot Projects • Regional Blood Flow
• Tomography, X-Ray Computed • blood supply*
• methods • methods* • radiography*},
Abstract = {PURPOSE: To measure mean cerebral blood flow (CBF) in
ischemic and nonischemic territories and in low-attenuation
regions in patients with acute stroke by using
deconvolution-derived hemodynamic imaging. MATERIALS AND
METHODS: Twelve patients with acute middle cerebral artery
stroke and 12 control patients were examined by using
single-section computed tomography (CT) perfusion scanning.
Analysis was performed with a deconvolution-based algorithm.
Comparisons of mean CBF, cerebral blood volume (CBV), and
mean transit time (MTT) were determined between hemispheres
in all patients and between low- and normal-attenuation
regions in patients with acute stroke. Two independent
readers examined the images for extent of visually apparent
regional perfusion abnormalities. The data were compared
with extent of final infarct in seven patients with acute
stroke who underwent follow-up CT or magnetic resonance
imaging. RESULTS: Significant decreases in CBF (-50%, P
=.001) were found in the affected hemispheres of patients
with acute stroke. Significant changes in CBV (-26%, P =.03)
and MTT (+111%, P =.004) were also seen. Significant
alterations in perfusion were also seen in low- compared
with normal-attenuation areas. Pearson correlation between
readers for extent of CBF abnormality was 0.94 (P =.001).
Intraobserver variation was 8.9% for CBF abnormalities.
CONCLUSION: Deconvolution analysis of CT perfusion data is a
promising method for evaluation of cerebral hemodynamics in
patients with acute stroke.},
Key = {fds132140}
}
@article{fds132123,
Author = {DC Steffens and HB Bosworth and JM Provenzale, JR
MacFall},
Title = {Subcortical white matter lesions and functional impairment
in geriatric depression.},
Journal = {Depression and anxiety},
Volume = {15},
Number = {1},
Pages = {23-8},
Year = {2002},
ISSN = {1091-4269},
Keywords = {Activities of Daily Living • Aged • Brain •
Cognition Disorders • Depressive Disorder, Major •
Female • Humans • Magnetic Resonance Imaging
• Male • Middle Aged • Psychomotor Disorders
• Severity of Illness Index • diagnosis •
etiology* • pathology* • physiopathology •
psychology*},
Abstract = {Geriatric depression is associated with significant
functional impairment. There is also growing evidence
linking vascular brain changes to depression in late life.
We sought to examine the relationship between
cerebrovascular disease and impairment in basic activities
of daily living (BADL) and instrumental activities of daily
living (IADL) in a group of older depressives. The sample
consisted of 224 depressed adults aged 60 years and above
enrolled in Duke's Mental Health Clinical Research Center.
All subjects had unipolar major depression and were free of
other major psychiatric and neurological illness, including
dementia. In a structured interview, subjects reported their
medical history and ability to perform both BADL and IADL.
Geriatric psychiatrists assessed cognition using the Mini
Mental State Examination (MMSE) and depression severity
using the Montgomery Asberg Depression Rating Scale (MADRS).
Subjects had a standardized magnetic resonance imaging (MRI)
brain scan. MRI scans were processed using a semi-automated
method to determine volumes of subcortical white matter
lesions (WML) and subcortical gray matter lesions (GML).
Logistic regression was used to examine effects of WML and
GML controlling for demographic and clinical factors.
Greater volume of WML was associated with impairment in both
BADL and IADL, while GML was associated with IADL
impairment. In logistic models, WML remained significantly
associated with IADL after controlling for the effects of
age, gender, depression severity, and medical comorbidity.
We concluded that white matter lesions are independently
associated with functional impairment. Further studies are
needed to understand how these lesions affect function,
e.g., through effects on cognition or motor
skills.},
Language = {eng},
Key = {fds132123}
}
@article{fds132165,
Author = {DV Lewis and DP Barboriak, JR MacFall and JM Provenzale and TV
Mitchell, KE VanLandingham},
Title = {Do prolonged febrile seizures produce medial temporal
sclerosis? Hypotheses, MRI evidence and unanswered
questions.},
Journal = {Progress in brain research, Netherlands},
Volume = {135},
Pages = {263-78},
Year = {2002},
ISSN = {0079-6123},
Keywords = {Animals • Epilepsy • Hippocampus • Humans
• Magnetic Resonance Imaging • Sclerosis •
Seizures • Seizures, Febrile • Temporal Lobe
• etiology • pathology • pathology*},
Abstract = {Whether or not severe febrile seizures in infancy cause
hippocampal injury and subsequent medial temporal sclerosis
is an often debated question in epilepsy. Recent magnetic
resonance imaging (MRI) of infants suffering from febrile
seizures has provided preliminary evidence that abnormally
increased T2 signal intensity can be seen in the hippocampi
of infants following prolonged and focal febrile seizures.
Follow-up MRIs in a few of these infants have confirmed that
medial temporal sclerosis can develop following these acute
MRI signal changes. In this article, we review the
hypotheses and MRI evidence relating to hippocampal injury
during prolonged febrile seizures and the later development
of medial temporal sclerosis.},
Key = {fds132165}
}
@article{fds132122,
Author = {AC Guo and VL Jewells and JM Provenzale},
Title = {Analysis of normal-appearing white matter in multiple
sclerosis: comparison of diffusion tensor MR imaging and
magnetization transfer imaging.},
Journal = {AJNR. American journal of neuroradiology},
Volume = {22},
Number = {10},
Pages = {1893-900},
Year = {2001},
Month = {December},
ISSN = {0195-6108},
Keywords = {Adult • Anisotropy • Brain • Female •
Humans • Image Processing, Computer-Assisted •
Magnetic Resonance Imaging • Male • Multiple
Sclerosis, Relapsing-Remitting • Sensitivity and
Specificity • diagnosis* • methods* •
pathology • pathology*},
Abstract = {OBJECTIVE: Our purpose was to compare diffusion tensor MR
and magnetization transfer imaging in assessing
normal-appearing white matter (WM) regions in multiple
sclerosis (MS). METHODS: Diffusion tensor, magnetization
transfer, and conventional MR imaging were performed in 12
patients with MS. Fractional anisotropy, apparent diffusion
coefficients (ADCs), and magnetization transfer ratios
(MTRs) were measured in plaques, normal-appearing periplaque
WM (PWM) regions, and normal-appearing WM regions remote
from plaques. Mean fractional anisotropy, ADCs, and MTRs
were calculated and compared in WM regions. RESULTS:
Fractional anisotropy was lower in normal-appearing PWM
regions than in remote WM regions (P <.001) but higher than
in plaques (P <.001). MTRs were lower (not significantly, P
=.19) in normal-appearing PWM regions than in remote
regions. MTRs were higher in normal-appearing PWM regions
than in plaques (P <.001). ADCs were higher in
normal-appearing PWM regions than in remote regions (P
=.008) but lower than in plaques (P =.001). Correlation
between fractional anisotropy and MTRs of individual lesions
was poor (r = 0.18) and between fractional anisotropy and
ADC, modest (r = -0.39). CONCLUSIONS: In MS, diffusion
tensor MR imaging can depict differences between WM regions
that are not apparent on conventional MR images. Anisotropy
measurements may be more sensitive than those of MTRs in
detecting subtle abnormalities in PWM.},
Language = {eng},
Key = {fds132122}
}
@article{fds132153,
Author = {JD Eastwood and DA Turner and RE McLendon and JM Provenzale},
Title = {Diffusion-weighted MR imaging in a patient with spinal
meningioma.},
Journal = {AJR. American journal of roentgenology},
Volume = {177},
Number = {6},
Pages = {1479-81},
Year = {2001},
Month = {December},
ISSN = {0361-803X},
Keywords = {Humans • Magnetic Resonance Imaging* • Male •
Meningeal Neoplasms • Meningioma • Middle Aged
• methods • pathology*},
Language = {eng},
Key = {fds132153}
}
@article{fds132131,
Author = {MS Wainwright and PL Martin and RP Morse and M Lacaze and JM Provenzale and RE Coleman and MA Morgan and C Hulette and J Kurtzberg and C Bushnell and L
Epstein, DV Lewis},
Title = {Human herpesvirus 6 limbic encephalitis after stem cell
transplantation.},
Journal = {Annals of neurology},
Volume = {50},
Number = {5},
Pages = {612-9},
Year = {2001},
Month = {November},
ISSN = {0364-5134},
Keywords = {Adolescent • Adrenoleukodystrophy • Adult •
Anemia, Diamond-Blackfan • Child • DNA, Viral
• Electroencephalography • Encephalitis, Viral
• Fatal Outcome • Fetal Blood •
Fluorodeoxyglucose F18 • Hematopoietic Stem Cell
Transplantation • Herpesvirus 6, Human •
Hippocampus • Humans • Immunohistochemistry •
Leukemia • Limbic Encephalitis • Magnetic
Resonance Imaging • Memory Disorders • Seizures
• Sleep Disorders • Tomography, Emission-Computed
• adverse effects* • beta-Thalassemia •
cerebrospinal fluid • complications • diagnosis*
• diagnostic use • etiology • isolation &
purification* • pathology • physiopathology •
radionuclide imaging • therapy •
virology*},
Abstract = {Central nervous system complications are common in stem cell
transplant recipients, but selective involvement of the
medial temporal area is unusual. The 5 patients reported
here presented after stem cell transplantation with
increased hippocampal T2 signal on magnetic resonance
imaging and increased hippocampal glucose uptake on
[F-18]fluorodeoxyglucose-positron emission tomography
(FDG-PET) associated with short-term memory loss, insomnia,
and temporal lobe electrographic seizure activity. The
initial scalp electroencephalograms (EEGs) failed to detect
seizure activity in these patients, although the memory
dysfunction along with the magnetic resonance imaging and
FDG-PET findings suggested subcortical seizure activity.
However, extended EEG monitoring revealed repetitive
temporal lobe electrographic seizure activity. Follow-up
MRIs in 2 patients and postmortem findings on 1 patient
suggested that hippocampal sclerosis had developed following
the clinical syndrome. Cerebrospinal fluid studies revealed
the presence of human herpesvirus 6, variant B, DNA in all
of 3 patients who had lumbar punctures. Immunohistochemical
staining for the P41 and P101 human herpesvirus 6 protein
antigens showed numerous immunoreactive astrocytes and
neurons in the hippocampus of 1 of the patients who died
from other causes. Because of its subtle clinical
presentation, this syndrome may be underrecognized, but can
be diagnosed with appropriate magnetic resonance imaging
techniques, EEG monitoring, and cerebrospinal fluid viral
studies.},
Language = {eng},
Key = {fds132131}
}
@article{fds131974,
Author = {DM Yousem and D Hammoud and EJ Russell and RD Zimmerman and WS Ball and WP
Dillon, JM Provenzale and FJ Wippold 2nd and S
Gebarski},
Title = {Results of the neuroradiology fellowship match for July 1,
2002 candidates.},
Journal = {AJNR. American journal of neuroradiology},
Volume = {22},
Number = {9},
Pages = {1654-8},
Year = {2001},
Month = {October},
ISSN = {0195-6108},
Keywords = {Fellowships and Scholarships • Neuroradiography* •
Questionnaires* • Radiology • United States •
education* • statistics & numerical
data*},
Language = {eng},
Key = {fds131974}
}
@article{fds132168,
Author = {S Gururangan and L Cokgor and JN Rich and S Edwards and ML Affronti and JA
Quinn, JE Herndon 2nd and JM Provenzale and RE McLendon and S
Tourt-Uhlig, JH Sampson and V Stafford-Fox and S Zaknoen and M Early and AH Friedman and HS Friedman},
Title = {Phase I study of Gliadel wafers plus temozolomide in adults
with recurrent supratentorial high-grade
gliomas.},
Journal = {Neuro-oncology},
Volume = {3},
Number = {4},
Pages = {246-50},
Year = {2001},
Month = {October},
ISSN = {1522-8517},
Keywords = {Adult • Aged • Antineoplastic Combined
Chemotherapy Protocols • Astrocytoma • Carmustine
• Cohort Studies • Dacarbazine • Disease
Progression • Dose-Response Relationship, Drug •
Drug Implants • Drug Synergism • Female •
Glioblastoma • Humans • Magnetic Resonance Imaging
• Male • Maximum Tolerated Dose • Middle Aged
• Safety • Supratentorial Neoplasms •
Thrombocytopenia • Treatment Outcome •
administration & dosage • administration & dosage*
• adverse effects • analogs & derivatives •
chemically induced • drug therapy* • pathology
• therapeutic use*},
Abstract = {Both Gliadel wafers [1,3-bis(2-chloroethyl)-1-nitrosourea]
and temozolomide (TEMO) have been shown in independent
studies to prolong survival of patients with recurrent
malignant glioma following surgery and radiotherapy. On the
basis of preclinical evidence of synergism between Gliadel
wafers and TEMO, a phase I study was designed to evaluate
the toxicity of combining these 2 agents in the treatment of
patients with recurrent supratentorial malignant glioma. All
patients had surgical resection of the tumor at relapse, and
up to 8 Gliadel (3.85%) wafers were placed in the surgical
cavity following resection. Two weeks after surgery, TEMO
was given orally daily for 5 days. Cohorts of 3 patients
received TEMO at daily doses of 100 mg/m2, 150 mg/m2, and
200 mg/m2, respectively. Patients were assessed for toxicity
4 weeks after start of the first course of TEMO.
Contrast-enhanced MRI of the brain was used to assesstumor
response after the first cycle of TEMO. Patients with stable
disease or response after the first cycle of TEMO were
allowed to continue treatment at the same dose every 4 weeks
for 12 cycles or until disease progression or unacceptable
toxicity. Ten patients with a median age of 47 years (range,
22-66 years) were enrolled in this study. There were 7
patients with glioblastoma multiforme and 3 patients with
anaplastic astrocytoma. Three patients were treated with
TEMO at the first dose level of 100 mg/m2, 4 at the second
dose level of 150 mg/m2, and 3 at the third dose level of
200 mg/m2. The 10 patients received a median of 3 cycles
(range, 1-12 cycles) of TEMO following placement of Gliadel
wafers. The treatment was well tolerated, with only 1
patient suffering grade III thrombocytopenia at the highest
dose level. Two patients at each dose level had no evidence
of disease progression after treatment. Four patients
suffered progressive disease on therapy. Our study
demonstrates that TEMO can be given safely after placement
of Gliadel (3.85%) wafers. The recommended dosage for TEMO
for a phase II study of this combination is 200 mg/m2 per
day for 5 days.},
Language = {eng},
Key = {fds132168}
}
@article{fds132103,
Author = {JM Provenzale, JR Petrella and LC Cruz Jr and JC Wong and S Engelter and DP Barboriak},
Title = {Quantitative assessment of diffusion abnormalities in
posterior reversible encephalopathy syndrome.},
Journal = {AJNR. American journal of neuroradiology},
Volume = {22},
Number = {8},
Pages = {1455-61},
Year = {2001},
Month = {September},
ISSN = {0195-6108},
Keywords = {Adult • Brain • Confusion • Diffusion •
Edema • Female • Headache • Humans •
Magnetic Resonance Imaging • Male • Seizures
• Syndrome • Vascular Diseases • Vision
Disorders • complications • diagnosis •
diagnosis* • etiology • methods* •
pathology*},
Abstract = {OBJECTIVE: Previous studies have shown that lesions in
posterior reversible encephalopathy syndrome are often
isointense on diffusion-weighted MR images. We hypothesized
that 1) apparent diffusion coefficient (ADC) maps using
various thresholds would show larger abnormalities in
posterior white matter (WM) and 2) isointense appearance of
lesions on isotropic diffusion-weighted images results from
a balance of T2 prolongation effects and diffusibility
effects. METHODS: T2-weighted MR images from 11 patients
were reviewed. Hyperintense lesions were located in both
anterior and posterior WM in eight patients and solely in
posterior WM in three patients. The ADC maps were produced
by use of ADC values > or = 3 SD and > or = 10 SD above the
mean value of normal WM. Lesions on diffusion-weighted
images were classified as isointense or hypointense. ADC
values within lesions (ADC(L)) were compared with those of
normal WM (ADC(N)), and compared for isointense lesions and
hypointense lesions. RESULTS: The distribution of lesions
with ADC values > or = 3 SD was essentially identical to
that on T2-weighted images. Regions with ADC values > or =
10 SD were found in both anterior WM and posterior WM in two
patients and solely in posterior WM in nine patients. On
diffusion-weighted images, lesions appeared isointense in
seven patients and hypointense in four patients. Mean
ADC(L)/ADC(N) for all lesions was 1.81; for hypointense
lesions, 2.30. CONCLUSIONS: Vasogenic edema was more severe
in posterior WM. Isointense lesions result from a balance of
T2 effects and increased water diffusibility. Hypointense
lesions have higher ADC values, which are not balanced by T2
effects.},
Language = {eng},
Key = {fds132103}
}
@article{fds132141,
Author = {EP Ahearn and KR Jamison and DC Steffens and F Cassidy and JM
Provenzale, A Lehman and RH Weisler and BJ Carroll and KR
Krishnan},
Title = {MRI correlates of suicide attempt history in unipolar
depression.},
Journal = {Biological psychiatry},
Volume = {50},
Number = {4},
Pages = {266-70},
Year = {2001},
Month = {August},
ISSN = {0006-3223},
Keywords = {Aged • Brain • Depressive Disorder •
Electroconvulsive Therapy • Female • Humans •
Magnetic Resonance Imaging* • Male • Suicide,
Attempted • abnormalities* • physiopathology*
• psychology* • therapy},
Abstract = {BACKGROUND: Suicide represents a major health problem in the
United States, and prediction of suicide attempts is
difficult. No structural neuroimaging studies have been done
to specifically examine findings in patients who have
attempted suicide. The objective of this study was to
compare MRI findings in unipolar patients with and without a
history of a suicide attempt. METHODS: In this post hoc
analysis, 20 unipolar subjects with a history of a suicide
attempt were matched by age and gender to unipolar subjects
without a history of an attempt. Subjects were also matched
on parameters such as cardiovascular history,
electroconvulsive treatment history, and history of
psychosis. Subjects with a history of any neurologic
condition were excluded. There were no significant
differences in age of onset of depression, number of
episodes of depression, and Hamilton Depression scores
between the two groups. T2-weighted magnetic resonance
imaging (MRI) scans were rated using the Coffey and Boyko
rating scales. RESULTS: Unipolar patients with a history of
a suicide attempt demonstrated significantly more
subcortical gray matter hyperintensities compared with
patients without such a history. CONCLUSIONS: Patients with
abnormal MRI findings may be at higher risk for mood
disorders and suicide attempts because of disruption of
critical neuroanatomic pathways. Gray matter
hyperintensities in the basal ganglia may be especially
associated with risk for suicide attempts.},
Language = {eng},
Key = {fds132141}
}
@article{fds131976,
Author = {WD Taylor and ME Payne and KR Krishnan and HR Wagner and JM Provenzale and DC Steffens, JR MacFall},
Title = {Evidence of white matter tract disruption in MRI
hyperintensities.},
Journal = {Biological psychiatry, United States},
Volume = {50},
Number = {3},
Pages = {179-83},
Year = {2001},
Month = {August},
ISSN = {0006-3223},
Keywords = {Aged • Anisotropy • Brain • Depressive
Disorder • Female • Functional Laterality •
Humans • Magnetic Resonance Imaging* • Male •
Severity of Illness Index • anatomy & histology* •
diagnosis • pathology* • physiology •
psychology*},
Abstract = {BACKGROUND: Diffusion tensor imaging (DTI) of brain tissue
measures the apparent diffusion coefficient (ADC), or
isotropic diffusion, and anisotropy, or diffusion as
influenced by tissue structure. We hypothesized that
hyperintensities, when compared with normal tissue by DTI,
would show evidence of damage through an increased ADC and
decreased anisotropy. We also hypothesized that DTI changes
in hyperintensities would be similar between depressed
subjects and control subjects. METHODS: Fourteen depressed
geriatric patients and nineteen control subjects received
DTI. The ADC and aniso-tropy of normal tissue from standard
regions were compared with hyperintensities from these
regions. The Students' t test compared individual regions
and averaged white matter results. RESULTS: Hyperintensities
showed higher ADC and lower anisotropy than normal regions.
Gray matter exhibited similar trends. There was no
significant difference in diffusion characteristics of
hyperintensities between subjects and control subjects.
CONCLUSIONS: Hyperintensities damage the structure of brain
tissue, and do so comparably in depressed subjects and
control subjects.},
Key = {fds131976}
}
@article{fds132105,
Author = {DJ Fiorella and JM Provenzale and RE Coleman and BJ Crain and AA
Al-Sugair},
Title = {(18)F-fluorodeoxyglucose positron emission tomography and MR
imaging findings in Rasmussen encephalitis.},
Journal = {AJNR. American journal of neuroradiology, United
States},
Volume = {22},
Number = {7},
Pages = {1291-9},
Year = {2001},
Month = {August},
ISSN = {0195-6108},
Keywords = {Adolescent • Adult • Atrophy • Biopsy •
Blood Glucose • Brain • Child • Child,
Preschool • Disease Progression • Dominance,
Cerebral • Encephalitis • Energy Metabolism •
Female • Fluorodeoxyglucose F18 • Follow-Up
Studies • Humans • Infant • Male •
Retrospective Studies • Tomography, Emission-Computed*
• diagnostic use • metabolism* • pathology
• physiology • physiopathology • radionuclide
imaging • radionuclide imaging*},
Abstract = {BACKGROUND AND PURPOSE: Rasmussen encephalitis is a chronic,
progressive encephalitis that manifests as an abrupt-onset,
intractable seizure disorder in previously developmentally
normal children. The objectives of the current study were to
characterize the (18)F-fluorodeoxyglucose (FDG) positron
emission tomography (PET) and MR imaging findings in
Rasmussen encephalitis and to test the hypotheses that data
from both imaging techniques are required to establish the
diagnosis and identify the affected cerebral hemisphere in
some cases. METHODS: Eleven patients with Rasmussen
encephalitis were identified from a review of a computer
database. The MR (n = 10) and PET (n = 11) imaging data were
reviewed retrospectively and conjointly. RESULTS: On MR
images, nine of 10 patients manifested bilateral cerebral
atrophy that predominantly involved one hemisphere. One
patient had purely unilateral cerebral atrophy. We observed
foci of abnormally increased T2 signal intensity in nine of
10 patients. On FDG PET images, all patients showed
extensive regions of hypometabolism within the cerebral
hemisphere that showed the greatest atrophy. Discrete foci
of hypermetabolism, indicative of seizure activity, were
observed in six patients. The FDG PET and MR imaging
findings were either stable or gradually progressive in
patients with multiple imaging studies (MR, n = 5; FDG PET,
n = 5). CONCLUSION: Rasmussen encephalitis is characterized
by diffuse, unilateral cerebral hypometabolism on FDG PET
images, with corresponding regions of cerebral atrophy on MR
images. Although MR imaging data alone are sufficient to
suggest a diagnosis of Rasmussen encephalitis in many cases,
correlation with FDG PET data increases diagnostic
confidence and allows the unequivocal identification of the
affected cerebral hemisphere in patients whose MR imaging
findings are subtle or distributed bilaterally.},
Key = {fds132105}
}
@article{fds132121,
Author = {AC Guo and JM Provenzale and LC Cruz, JR Petrella},
Title = {Cerebral abscesses: investigation using apparent diffusion
coefficient maps.},
Journal = {Neuroradiology, Germany},
Volume = {43},
Number = {5},
Pages = {370-4},
Year = {2001},
Month = {May},
ISSN = {0028-3940},
Keywords = {Brain Abscess • Diffusion • Humans • Magnetic
Resonance Imaging* • Male • Middle Aged •
pathology*},
Abstract = {The combination of high signal and reduced apparent
diffusion coefficients (ADC) within abscesses on
diffusion-weighted MRI (DWI) has been reported as
characteristic of abscesses, and useful for distinguishing
them from cystic or necrotic neoplasms. To assess whether
these are consistent findings in abscesses, we used
DWI-derived ADC to investigate changes in water
diffusibility in cerebral abscesses. We reviewed the MRI
studies and clinical records of five patients with brain
abscesses, who underwent DWI. Regions of interest were drawn
within the abscesses on ADC maps, to obtain the ADC. The
center of all five abscesses gave signal higher than that of
white matter on DWI. The three largest also appeared bright
on ADC maps, i. e., showed ADC substantially lower than
those of normal white matter, consistent with restricted
diffusion. However, the two smaller abscesses were not
visible on ADC maps because their ADC were essentially the
same as that of white matter; they did not show restricted
diffusion. The absence of restricted diffusion within small
abscesses may be related to intrinsic differences in
molecular microenvironment between small and large
abscesses, or to greater influence of volume averaging with
surrounding edema on the ADC in smaller abscesses.},
Key = {fds132121}
}
@article{fds132128,
Author = {JD Eastwood and DJ Fiorella and JF MacFall and DM Delong and JM
Provenzale, RS Greenwood},
Title = {Increased brain apparent diffusion coefficient in children
with neurofibromatosis type 1.},
Journal = {Radiology, United States},
Volume = {219},
Number = {2},
Pages = {354-8},
Year = {2001},
Month = {May},
ISSN = {0033-8419},
Keywords = {Adolescent • Body Water • Brain • Cerebellum
• Child • Diffusion • Female • Frontal
Lobe • Globus Pallidus • Hippocampus • Humans
• Magnetic Resonance Imaging* • Male •
Neurofibromatosis 1 • Prospective Studies •
Regression Analysis • Retrospective Studies •
Thalamus • metabolism • metabolism* •
pathology},
Abstract = {PURPOSE: To describe the changes in brain water
diffusibility in five anatomic locations in children with
neurofibromatosis type 1 (NF 1) compared with these changes
in control subjects and to describe the water diffusibility
changes associated with hyperintense basal ganglia lesions
in children with NF 1. MATERIALS AND METHODS: Twenty highly
related pairs of children consisting of one child with NF 1
and one unaffected child were examined. Prospective
comparisons of isotropic apparent diffusion coefficient
(ADC) values at five anatomic locations were performed, with
and without T2-hyperintense lesions included. Retrospective
analysis of hyperintense globus pallidus lesions in 16
children and in the paired control subjects also was
performed. RESULTS: Significant increases in ADC values were
seen in all five anatomic locations in the NF 1 group. The
greatest increases were seen in the globus pallidus (14%; P
=.002) and brachium pontis (10.8%; P =.003). With exclusion
of hyperintense lesions, significant ADC increases were
measured in four locations. Significant ADC increases were
seen in hyperintense globus pallidus lesions in the NF 1
group compared with ADC values in the normal-appearing
contralateral globus pallidus (4.9%; P =.02) and those in
the globus pallidus of the paired control subjects (16%; P
=.003). CONCLUSION: Significant ADC increases were measured
both in the hyperintense lesions and in the normal-appearing
areas of the brain in children with NF 1.},
Key = {fds132128}
}
@article{fds132161,
Author = {I Cokgor and G Akabani and HS Friedman and AH Friedman and MR Zalutsky and LM Zehngebot and JM Provenzale and CD Guy and CJ Wikstrand and DD
Bigner},
Title = {Long term response in a patient with neoplastic meningitis
secondary to melanoma treated with (131)I-radiolabeled
antichondroitin proteoglycan sulfate Mel-14 F(ab')(2): a
case study.},
Journal = {Cancer, United States},
Volume = {91},
Number = {9},
Pages = {1809-13},
Year = {2001},
Month = {May},
ISSN = {0008-543X},
Keywords = {Antibodies, Monoclonal • Chondroitin Sulfates •
Female • Humans • Iodine Radioisotopes •
L-Selectin • Melanoma • Meningitis • Middle
Aged • Radiopharmaceuticals • adverse effects
• etiology* • immunology • radiotherapy*
• therapeutic use*},
Abstract = {Even with novel chemotherapeutic agents and external beam
radiation therapy, the prognosis of neoplastic meningitis
secondary to malignant melanoma is still dismal. The authors
report a case study of a 46-year-old white female who
presented with progressive hearing loss, severe headaches,
nausea, vomiting, and a rapid decline in neurologic status.
She was referred to Duke University Medical Center after
conventional chemotherapy for malignant melanoma failed. She
was enrolled in a Phase I trial of (131)I-labeled monoclonal
antibody Mel-14 F(ab')(2) fragment administered
intrathecally. Within a year after her treatment, she
recovered, having a normal neurologic exam except for
residual bilateral hearing loss. The authors discuss
dosimetry, preclinical, and clinical studies conducted with
Mel-14 F(ab')(2) and introduce a potentially promising
therapy option in the treatment of neoplastic meningitis in
patients with malignant melanoma. Currently, the patient
remains neurologically normal except for a mild bilateral
hearing loss more than 4 years after treatment and has no
radiographic evidence of neoplastic meningitis.},
Key = {fds132161}
}
@article{fds132136,
Author = {ST Engelter and JM Provenzale, JR Petrella and MJ Alberts and DM
DeLong, JR MacFall},
Title = {Use of exponential diffusion imaging to determine the age of
ischemic infarcts.},
Journal = {Journal of neuroimaging : official journal of the American
Society of Neuroimaging},
Volume = {11},
Number = {2},
Pages = {141-7},
Year = {2001},
Month = {April},
ISSN = {1051-2284},
Keywords = {Adolescent • Adult • Aged • Aged, 80 and over
• Cerebral Infarction • Diffusion • Female
• Humans • Image Enhancement* • Image
Processing, Computer-Assisted • Magnetic Resonance
Imaging* • Male • Middle Aged • Sensitivity
and Specificity • diagnosis*},
Abstract = {OBJECTIVE: Diffusion-weighted magnetic resonance imaging
(DWI) detects acute ischemic infarcts with high lesion
conspicuity. Determination of infarct age is difficult on
DWI alone because infarct signal intensity (SIinfarct) on
DWI is influenced by T2 properties ("T2 shine-through").
Maps of the apparent diffusion coefficient (ADC) reflect
pure diffusion characteristics without T2 effects but have
low lesion conspicuity. Thus, in clinical practice, combined
use of DWI and ADC maps is required. Exponential DWI (eDWI)
is an innovative means of MRI-diffusion data analysis that
merges the advantages of DWI and ADC maps. The authors
hypothesized that SIinfarct on eDWI would correlate with
infarct age. The authors studied 114 consecutive patients
who had 120 ischemic strokes with clearly determined onset
times and who underwent echo-planar DWI. The eDWI were
generated by dividing the signal intensity on DWI by that on
the corresponding T2 image on a pixel-by-pixel basis.
SIinfarct on eDWI was measured in the lesion core and
expressed as a percentage of contralateral control tissue.
On eDWI, relative SIinfarct changed significantly with
infarct age (P < .0001). When patients were sorted in
infarct-age groups, no significant differences were found
within the first 120 hours. However, for patients studied
within 5 days, the mean relative SIinfarct was significantly
higher compared with patients studied > or = 8 days after
stroke (P < .05). For all infarcts up to 5 days old, the
eDWI signal intensity was higher than control tissue
(hyperintense appearance). All infarcts > 10 days old had an
eDWI signal intensity lower than control tissue (hypointense
appearance). The authors concluded that the use of eDWI, as
a single set of images, reliably differentiates acute
infarcts (< or = 5 days old) from infarcts > 10 days old.
This feature would be expected to be helpful when the
distinction between acute and nonacute infarction cannot be
determined on clinical grounds.},
Language = {eng},
Key = {fds132136}
}
@article{fds132001,
Author = {JD Eastwood and JM Provenzale and LM Hurwitz and TY
Lee},
Title = {Practical injection-rate CT perfusion imaging:
deconvolution-derived hemodynamics in a case of
stroke.},
Journal = {Neuroradiology, Germany},
Volume = {43},
Number = {3},
Pages = {223-6},
Year = {2001},
Month = {March},
ISSN = {0028-3940},
Keywords = {Brain • Cerebrovascular Accident • Contrast Media
• Drug Administration Schedule • Hemodynamic
Processes • Humans • Injections, Intravenous
• Male • Middle Aged • Regional Blood Flow
• Tomography, X-Ray Computed • administration &
dosage* • blood supply* • methods* •
pathology*},
Abstract = {Previously reported methods of dynamic, contrast-enhanced,
CT perfusion imaging in acute stroke have been promising but
substantially limited by their dependence on very rapid
rates of injection (typically 10-20 ml/s in an arm vein).
Newly available deconvolution software permits the use of
lower rates of injection (e. g., 3-4 ml/s), and rapidly
provides maps of cerebral blood flow, cerebral blood volume
and mean transit time. We report the potential of CT
perfusion imaging performed with an injection rate of 4 ml/s
to provide information on the extent of hemodynamic
abnormality, and to help distinguish viable from nonviable
ischemic tissue. The slower injection rates permitted by
deconvolution analysis substantially enhance the
practicality of CT perfusion imaging for studying
stroke.},
Key = {fds132001}
}
@article{fds132135,
Author = {AC Guo, JR Petrella and J Kurtzberg and JM Provenzale},
Title = {Evaluation of white matter anisotropy in Krabbe disease with
diffusion tensor MR imaging: initial experience.},
Journal = {Radiology, United States},
Volume = {218},
Number = {3},
Pages = {809-15},
Year = {2001},
Month = {March},
ISSN = {0033-8419},
Keywords = {Anisotropy • Brain • Child, Preschool •
Female • Hematopoietic Stem Cell Transplantation •
Humans • Infant • Infant, Newborn •
Leukodystrophy, Globoid Cell • Magnetic Resonance
Imaging • Male • diagnosis* • methods* •
pathology* • therapy},
Abstract = {PURPOSE: To compare diffusion tensor magnetic resonance
imaging with conventional T2-weighted imaging for evaluation
of white matter changes in patients with Krabbe disease.
MATERIALS AND METHODS: In eight patients with Krabbe disease
and eight age-matched control subjects, anisotropy maps were
generated with diffusion tensor data by using echo-planar
imaging with diffusion gradient encoding in six directions.
Anisotropy maps and T2-weighted images were visually
inspected. Relative anisotropy (RA) and normalized
T2-weighted signal intensity in white matter tracts and gray
matter nuclei were quantitatively compared between patients
and controls (paired Student t test). RESULTS: Loss of
diffusion anisotropy appeared on anisotropy maps as areas of
decreased hyperintensity in patients with Krabbe disease.
Differences in RA between Krabbe disease patients and
control subjects were significant in eight of nine white
matter structures studied (P =.001-.01) and in basal ganglia
(P =.04). T2-weighted signal intensity was also
significantly different in the same white matter structures
(P =.006-.049) but not in basal ganglia. In the three
patients imaged after stem cell transplantation, mean RA was
between the RAs of untreated patients and control subjects.
CONCLUSION: Diffusion tensor-derived anisotropy maps (a)
provide a quantitative measure of abnormal white matter in
patients with Krabbe disease, (b) are more sensitive than
T2-weighted images for detecting white matter abnormality,
and (c) may be a marker of treatment response.},
Key = {fds132135}
}
@article{fds132154,
Author = {DP Barboriak and L Lee and JM Provenzale},
Title = {Serial MR imaging of pineal cysts: implications for natural
history and follow-up.},
Journal = {AJR. American journal of roentgenology, United
States},
Volume = {176},
Number = {3},
Pages = {737-43},
Year = {2001},
Month = {March},
ISSN = {0361-803X},
Keywords = {Adult • Brain Diseases • Cysts • Female
• Follow-Up Studies • Humans • Magnetic
Resonance Imaging* • Male • Pineal Gland •
Retrospective Studies • Time Factors •
pathology*},
Abstract = {OBJECTIVE: The purpose of this study was to examine the
frequency of change in size of pineal cysts on serial MR
studies. MATERIALS AND METHODS: Thirty-two patients (19
females, 13 males) with a diagnosis of pineal cyst at any
time who underwent brain MR imaging more than once in a
period of at least 6 months were identified by computerized
search of radiology reports. Four patients underwent MR
imaging to follow up pineal cysts, whereas the remaining
patients were imaged for a variety of indications, including
intracerebral neoplasms. Measurements of maximal cyst
dimension on both initial and latest follow-up studies were
obtained in all patients, and cyst volumes were calculated
in 23 patients. RESULTS: Length of follow-up ranged from 6
months to 9 years. All cysts were considered incidental and
none were treated. Maximal cyst dimensions ranged from 0.5
to 2.2 cm. On average, there was no significant change in
cyst volume. The maximal dimension of the cyst did not
change in 24 (75%) of 32 patients. Two cysts resolved
completely on follow-up, three cysts decreased by 2-4 mm,
two cysts enlarged by 2-3 mm, and one cyst formed and grew
to 1.2 cm. CONCLUSION: Whereas the size of pineal cysts as a
whole remained unchanged on serial MR studies, cysts may
either form or involute in individual patients. Small
increases in cyst size did occur but were not associated
with specific clinical findings. These findings suggest that
typical pineal cysts may be followed up on a clinical basis
alone rather than on imaging.},
Key = {fds132154}
}
@article{fds132002,
Author = {M Neeman and JM Provenzale and MW Dewhirst},
Title = {Magnetic resonance imaging applications in the evaluation of
tumor angiogenesis.},
Journal = {Seminars in radiation oncology},
Volume = {11},
Number = {1},
Pages = {70-82},
Year = {2001},
Month = {January},
ISSN = {1053-4296},
Keywords = {Blood Volume • Capillary Permeability • Humans
• Magnetic Resonance Imaging* • Neoplasms •
Neovascularization, Pathologic • diagnosis* •
pathology},
Abstract = {Angiogenesis, the growth of new blood vessels, is a critical
component in the development of solid tumors. Over the last
decade, progress in the study of the biology of angiogenesis
has led to identification of a large number of molecules
that promote, participate, and regulate the growth of new
vessels in normal tissue and in tumors. Consequently, many
new targets for suppression of angiogenesis have been
identified and are now at various stages of development and
evaluation in clinical trials. Magnetic resonance imaging
(MRI) provides an attractive tool for in vivo analysis of
the basic biology of angiogenesis, for preclinical
evaluation of the activity of a number of potential
antiangiogenic agents, as well as for clinical detection,
diagnosis, and prognosis. One of the features of MRI is the
wide range of physiologic parameters by which angiogenesis
can be imaged. This review presents the biological basis of
angiogenesis with emphasis on characteristics of the
neovasculature that can be used for imaging, followed by an
overview of the MRI approaches that are being evaluated for
the analysis of tumor angiogenesis.},
Language = {eng},
Key = {fds132002}
}
@article{fds132102,
Author = {JM Hinman and JM Provenzale},
Title = {Nonischemic causes of hyperintense signals on
diffusion-weighted magnetic resonance images: a pictorial
essay.},
Journal = {Canadian Association of Radiologists journal = Journal
l'Association canadienne des radiologistes,
Canada},
Volume = {51},
Number = {6},
Pages = {351-7},
Year = {2000},
Month = {December},
ISSN = {0846-5371},
Keywords = {Adolescent • Adult • Aged • Artifacts •
Brain • Brain Diseases • Cerebral Infarction
• Child • Child, Preschool • Diagnosis,
Differential • Diffusion • Female • Humans
• Image Enhancement* • Infant • Magnetic
Resonance Imaging* • Male • Middle Aged •
diagnosis* • pathology},
Abstract = {A number of entities other than acute cerebral infarction
can produce bright signal intensity on diffusion-weighted
magnetic resonance images, and an understanding of the range
of possible diagnoses for these hyperintense lesions is
important for radiologists who must interpret these
images.},
Key = {fds132102}
}
@article{fds132142,
Author = {OL Harbury and JM Provenzale and DP Barboriak},
Title = {Vertex epidural hematomas: imaging findings and diagnostic
pitfalls.},
Journal = {European journal of radiology},
Volume = {36},
Number = {3},
Pages = {150-7},
Year = {2000},
Month = {December},
ISSN = {0720-048X},
Keywords = {Adult • Diagnosis, Differential • Female •
Hematoma, Epidural, Cranial • Humans • Magnetic
Resonance Angiography • Magnetic Resonance Imaging
• Male • Middle Aged • Skull •
Tomography, X-Ray Computed • diagnosis* •
etiology},
Abstract = {OBJECTIVE: Our purpose was to show the computed tomography
(CT) and magnetic resonance (MR) imaging features of vertex
epidural hematomas (EDHs) and emphasize pitfalls in the
diagnosis of this entity. METHODS: The neuroradiologic
studies of four patients (CT in four, MR imaging and MR
venography in one) were evaluated for EDH shape, size and
appearance. RESULTS: EDHs were biconvex in three patients
and crescentic in one patient. CT appearances included a
collection that was hyperdense (two patients), generally
isodense with a few regions of hyperdensity (one patient)
and mixed hyperdense and hypodense (one patient). MR imaging
findings in one patient consisted of hyperintense signal on
T1-weighted images and hypointense signal on T2-weighted
images. Inferior displacement of the superior sagittal sinus
was seen in two patients. Diagnosis of a small vertex EDH
was difficult on routine axial CT in one patient, but
apparent on MR imaging and MR venography. CONCLUSIONS: Small
vertex EDHs can be difficult to diagnose on routine CT. MR
imaging or thin section CT should be performed to exclude
the diagnosis in patients with trauma to the skull
vertex.},
Language = {eng},
Key = {fds132142}
}
@article{fds131994,
Author = {ST Engelter and JM Provenzale, JR Petrella},
Title = {Assessment of vasogenic edema in eclampsia using diffusion
imaging.},
Journal = {Neuroradiology},
Volume = {42},
Number = {11},
Pages = {818-20},
Year = {2000},
Month = {November},
ISSN = {0028-3940},
Keywords = {Adult • Brain Edema • Eclampsia • Female
• Humans • Hypertension • Magnetic Resonance
Imaging • Posterior Cerebral Artery • Pregnancy
• complications • complications* • diagnosis*
• etiology • pathology},
Abstract = {We qualitatively assessed the regional distribution of
vasogenic edema in a case of postpartum eclampsia. Although
diffusion-weighted imaging showed no abnormalities,
bilateral high signal was seen on T2-weighted images and
apparent diffusion coefficient (ADC) maps. ADC of 1.45 +/-
0.10 mm2/s x 10(-3) for the posterior cerebral artery (PCA)
territory and 1.22 +/- 0.12 mm2/s x 10(-3) for the watershed
areas were significantly higher than those in the
territories of the anterior (0.85 +/- 0.07 mm2/s x 10(-3)
and middle cerebral (0.79 +/- 0.06 mm2/s x 10(-3)) arteries
(P < 0.05). The predilection of ADC changes within the PCA
territory and in a previously undescribed watershed
distribution supports the hypothesis that vasogenic edema in
eclampsia is due to hypertension-induced failure of vascular
autoregulation.},
Language = {eng},
Key = {fds131994}
}
@article{fds132180,
Author = {I Cokgor and G Akabani and CT Kuan and HS Friedman and AH Friedman and RE
Coleman, RE McLendon and SH Bigner and XG Zhao and AM Garcia-Turner and CN Pegram and CJ Wikstrand and TD Shafman and JE Herndon and JM
Provenzale, MR Zalutsky and DD Bigner},
Title = {Phase I trial results of iodine-131-labeled antitenascin
monoclonal antibody 81C6 treatment of patients with newly
diagnosed malignant gliomas.},
Journal = {Journal of clinical oncology : official journal of the
American Society of Clinical Oncology, UNITED
STATES},
Volume = {18},
Number = {22},
Pages = {3862-72},
Year = {2000},
Month = {November},
ISSN = {0732-183X},
Keywords = {Adult • Aged • Animals • Antibodies,
Monoclonal • Combined Modality Therapy • Female
• Follow-Up Studies • Glioma • Humans •
Immunotoxins • Magnetic Resonance Imaging • Male
• Mice • Mice, Nude • Middle Aged •
Supratentorial Neoplasms • Survival Analysis •
Tenascin • Tomography, Emission-Computed • adverse
effects • immunology • immunology* •
radionuclide imaging • radiotherapy* • surgery
• therapeutic use*},
Abstract = {PURPOSE: To determine the maximum-tolerated dose (MTD) of
iodine-131 ((131)I)-labeled 81C6 antitenascin monoclonal
antibody (mAb) administered clinically into surgically
created resection cavities (SCRCs) in malignant glioma
patients and to identify any objective responses with this
treatment. PATIENTS AND METHODS: In this phase I trial,
newly diagnosed patients with malignant gliomas with no
prior external-beam therapy or chemotherapy were treated
with a single injection of (131)I-labeled 81C6 through a
Rickham reservoir into the resection cavity. The initial
dose was 20 mCi and escalation was in 20-mCi increments.
Patients were observed for toxicity and response until death
or for a minimum of 1 year after treatment. RESULTS: We
treated 42 patients with (131)I-labeled 81C6 mAb in
administered doses up to 180 mCi. Dose-limiting toxicity was
observed at doses greater than 120 mCi and consisted of
delayed neurotoxicity. None of the patients developed major
hematologic toxicity. Median survival for patients with
glioblastoma multiforme and for all patients was 69 and 79
weeks, respectively. CONCLUSION: The MTD for administration
of (131)I-labeled 81C6 into the SCRC of newly diagnosed
patients with no prior radiation therapy or chemotherapy was
120 mCi. Dose-limiting toxicity was delayed neurologic
toxicity. We are encouraged by the survival and toxicity and
by the low 2.5% prevalence of debulking surgery for
symptomatic radiation necrosis.},
Key = {fds132180}
}
@article{fds132138,
Author = {HS Friedman and J Pluda and JA Quinn and RB Ewesuedo and L Long and AH
Friedman, I Cokgor and OM Colvin and MM Haglund and DM Ashley and JN
Rich, J Sampson and AE Pegg and RC Moschel and RE McLendon and JM
Provenzale, ES Stewart and S Tourt-Uhlig and AM Garcia-Turner and JE
Herndon, DD Bigner and ME Dolan},
Title = {Phase I trial of carmustine plus O6-benzylguanine for
patients with recurrent or progressive malignant
glioma.},
Journal = {Journal of clinical oncology : official journal of the
American Society of Clinical Oncology, UNITED
STATES},
Volume = {18},
Number = {20},
Pages = {3522-8},
Year = {2000},
Month = {October},
ISSN = {0732-183X},
Keywords = {Adult • Antineoplastic Combined Chemotherapy Protocols
• Astrocytoma • Carmustine • Central Nervous
System Neoplasms • Drug Administration Schedule •
Glioblastoma • Guanine • Humans • Middle Aged
• Neoplasm Recurrence, Local • administration &
dosage • adverse effects • adverse effects* •
analogs & derivatives* • blood • drug therapy
• drug therapy* • pharmacokinetics •
therapeutic use},
Abstract = {PURPOSE: The major mechanism of resistance to
alkylnitrosourea therapy involves the DNA repair protein
O(6)-alkylguanine-DNA alkyltransferase (AGT), which removes
chloroethylation or methylation damage from the O(6)
position of guanine. O(6)-benzylguanine (O(6)-BG) is an AGT
substrate that inhibits AGT by suicide inactivation. We
conducted a phase I trial of carmustine (BCNU) plus O(6)-BG
to define the toxicity and maximum-tolerated dose (MTD) of
BCNU in conjunction with the preadministration of O(6)-BG
with recurrent or progressive malignant glioma. PATIENTS AND
METHODS: Patients were treated with O(6)-BG at a dose of 100
mg/m(2) followed 1 hour later by BCNU. Cohorts of three to
six patients were treated with escalating doses of BCNU, and
patients were observed for at least 6 weeks before being
considered assessable for toxicity. Plasma samples were
collected and analyzed for O(6)-BG, 8-oxo-O(6)-BG, and
8-oxoguanine concentration. RESULTS: Twenty-three patients
were treated (22 with glioblastoma multiforme and one with
anaplastic astrocytoma). Four dose levels of BCNU (13.5, 27,
40, and 55 mg/m(2)) were evaluated, with the highest dose
level being complicated by grade 3 or 4 thrombocytopenia and
neutropenia. O(6)-BG rapidly disappeared from plasma
(elimination half-life = 0. 54 +/- 0.14 hours) and was
converted to a longer-lived metabolite, 8-oxo-O(6)-BG
(elimination half-life = 5.6 +/- 2.7 hours) and further to
8-oxoguanine. There was no detectable O(6)-BG 5 hours after
the start of the O(6)-BG infusion; however, 8-oxo-O(6)-BG
and 8-oxoguanine concentrations were detected 25 hours after
O(6)-BG infusion. The mean area under the concentration-time
curve (AUC) of 8-oxo-O(6)-BG was 17.5 times greater than the
mean AUC for O(6)-BG. CONCLUSION: These results indicate
that the MTD of BCNU when given in combination with O(6)-BG
at a dose of 100 mg/m(2) is 40 mg/m(2) administered at
6-week intervals. This study provides the foundation for a
phase II trial of O(6)-BG plus BCNU in nitrosourea-resistant
malignant glioma.},
Key = {fds132138}
}
@article{fds131992,
Author = {ST Engelter and JM Provenzale, JR Petrella and DM DeLong, JR
MacFall},
Title = {The effect of aging on the apparent diffusion coefficient of
normal-appearing white matter.},
Journal = {AJR. American journal of roentgenology, UNITED
STATES},
Volume = {175},
Number = {2},
Pages = {425-30},
Year = {2000},
Month = {August},
ISSN = {0361-803X},
Keywords = {Adult • Aged • Aged, 80 and over • Aging*
• Brain • Diffusion • Female • Humans
• Magnetic Resonance Imaging* • Male • Middle
Aged • Thalamus • anatomy & histology •
anatomy & histology*},
Abstract = {OBJECTIVE: The purpose of our study was to test the
hypothesis that the apparent diffusion coefficient (ADC) of
normal-appearing white matter increases with advancing age.
SUBJECTS AND METHODS: We selected 38 patients with normal MR
imaging findings from 332 patients undergoing clinical MR
imaging. Diffusion-weighted MR imaging was performed with
diffusion gradients applied in three orthogonal directions.
For each patient, the average ADC on trace-weighted
diffusion images of white matter at prespecified regions of
interest and at the thalamus were compared with the
patient's age. RESULTS: For the white matter, ADC sorted by
patient age in decades increased with advancing age.
Patients at least 60 years old had significantly higher ADC
(0.769 +/- 0.019 mm(2)/sec x 10(-3)) than patients less than
60 years old (0.740 +/- 0.013 mm(2)/sec x 10(-3)) (p <
0.001). Comparison of individual white matter ADC and age
showed a significant increase with advancing age (p <
0.0001). For the thalamus, the average ADC among patients at
least 60 years old (0.766 +/- 0.015 mm(2)/sec x 10(-3))
exceeded the average ADC for patients less than 60 years old
(0.745 +/- 0.022 mm(2)/sec x 10(-3)) (p < 0.05). However,
comparison of individual thalamic ADC and patient ages,
although showing a trend to higher ADC with increasing age,
did not reach statistical significance (p = 0.06).
CONCLUSION: Advancing age is associated with a small but
statistically significant increase of water diffusibility in
human white matter. A similar trend was present in the
thalamus. These increases may reflect mild structural
changes associated with normal aging.},
Key = {fds131992}
}
@article{fds131965,
Author = {JR Petrella and JM Provenzale},
Title = {MR perfusion imaging of the brain: techniques and
applications.},
Journal = {AJR. American journal of roentgenology, UNITED
STATES},
Volume = {175},
Number = {1},
Pages = {207-19},
Year = {2000},
Month = {July},
ISSN = {0361-803X},
Keywords = {Brain • Brain Diseases • Cerebrovascular
Circulation • Humans • Magnetic Resonance Imaging*
• anatomy & histology* • pathology*},
Key = {fds131965}
}
@article{fds132104,
Author = {RI Grossman and DL Rubin and G Hunter and VM Haughton and D Lee and G Sze and MJ Kuhn and K Maravilla and R Tu and W Heindel and FJ Wippold and N Leeds and J Zelch, JR Jinkins and W Grodd and C Truwit and E Kanal and JM
Provenzale, R Ramsey and J Simon and JA Brunberg and GR Stevens and RM
Kristy},
Title = {Magnetic resonance imaging in patients with central nervous
system pathology: a comparison of OptiMARK (Gd-DTPA-BMEA)
and Magnevist (Gd-DTPA).},
Journal = {Investigative radiology, UNITED STATES},
Volume = {35},
Number = {7},
Pages = {412-9},
Year = {2000},
Month = {July},
ISSN = {0020-9996},
Keywords = {Adult • Aged • Brain • Central Nervous System
Diseases • Contrast Media* • Double-Blind Method
• Female • Gadolinium • Gadolinium DTPA
• Humans • Male • Middle Aged •
Organometallic Compounds • Spinal Cord • adverse
effects • diagnostic use • diagnostic use* •
pathology • pathology*},
Abstract = {RATIONALE AND OBJECTIVES: The objective of the two pivotal
phase 3 studies was to evaluate the safety and efficacy of
OptiMARK (Gd-DTPA-bis(methoxyethylamide) [Gd-DTPA-BMEA])
compared with Magnevist (Gd-DTPA) in magnetic resonance
imaging of the central nervous system. METHODS: Two
multicenter, randomized, double-blind, parallel group
studies were conducted in 395 patients with known or
suspected central nervous system pathology. Subjects were
randomized to receive a single 0.1 mmol/kg intravenous
injection of either Gd-DTPA-BMEA or Gd-DTPA. The safety of
Gd-DTPA-BMEA and Gd-DTPA was monitored for up to 72 hours
after study drug administration. Precontrast and
postcontrast administration magnetic resonance scans were
acquired using identical imaging planes and techniques.
RESULTS: No deaths or unexpected adverse events were
reported in either group. A comparison of adverse events by
intensity and relation demonstrated no statistically
significant differences between the two groups. Gd-DTPA-BMEA
and Gd-DTPA were equivalent with respect to confidence in
diagnosis, conspicuity, and border delineation. CONCLUSIONS:
Gd-DTPA-BMEA and Gd-DTPA demonstrated comparable efficacy
profiles, and the safety profiles were considered
similar.},
Key = {fds132104}
}
@article{fds132130,
Author = {TJ Cummings and JM Provenzale and SB Hunter and AH Friedman and GK
Klintworth, SH Bigner and RE McLendon},
Title = {Gliomas of the optic nerve: histological,
immunohistochemical (MIB-1 and p53), and MRI
analysis.},
Journal = {Acta neuropathologica, GERMANY},
Volume = {99},
Number = {5},
Pages = {563-70},
Year = {2000},
Month = {May},
ISSN = {0001-6322},
Keywords = {Adolescent • Adult • Aged • Antigens, Nuclear
• Astrocytoma • Child • Child, Preschool
• Female • Humans • Immunohistochemistry
• Infant • Ki-67 Antigen • Magnetic Resonance
Imaging* • Male • Nuclear Proteins • Optic
Nerve Neoplasms • Tumor Suppressor Protein p53 •
analysis • analysis* • chemistry •
pathology*},
Abstract = {Gliomas of the optic nerve, although typically of pilocytic
(WHO grade I) histology, can present within the spectrum of
astrocytic neoplasia including glioblastoma (WHO grade IV).
In certain cases, histologic features alone make the
distinction between pilocytic and diffuse astrocytomas
difficult. We reviewed 22 cases of optic nerve gliomas, 19
of which were pilocytic astrocytomas (PA), and 3 of which
were diffuse, non-pilocytic astrocytomas. The cases were
evaluated for their clinical course, radiographic
appearance, histologic grade, and proliferation indices as
detected by MIB-1 (Ki-67) and p53 antibodies. Of the 19 PA,
14 showed no tumor growth by magnetic resonance imaging, and
had Ki-67 and p53 labeling indices (LI) of < 1%. The other 5
PA exhibited aggressive behavior manifest by marked diffuse
infiltrative tumor growth causing death in 2 patients, 1 of
whom was diagnosed with neurofibromatosis type 1
(immunoperoxidase and radiographs not available), and marked
local growth with an average time to growth of 39.3 months,
a Ki-67 LI of 2-3%, and a p53 LI of < 1% in three others.
Three of the five aggressive PA histologically demonstrated
a finely reticulated pattern, a pattern that appears as an
exaggeration or expansion of the normal neuroglia of the
optic nerve, and may simulate a diffuse low-grade
astrocytoma. Two demonstrated the coarsely reticulated
pattern, with the biphasic and microcystic pattern typical
of PA. Three diffuse astrocytomas (2 anaplastic astrocytomas
and 1 glioblastoma) originated clinically and
radiographically from the optic nerve, and revealed a Ki-67
LI of 2-12%, a p53 LI of 2-8%, and an average time to growth
of 8 months. We conclude that the majority of PA of the
optic nerve are non-aggressive, stabilize radiographically,
and have Ki-67 and p53 LI < 1%. However, a subpopulation of
PA has a propensity for aggressive behavior, and are
identified by a Ki-67 LI of 2-3% and a p53 LI of < 1%.
Diffuse astrocytomas have both Ki-67 and p53 LI > 2%. Thus,
in cases of aggressive optic nerve tumors in which the
histologic review of biopsy material cannot confidently
confirm the diagnosis of pilocytic or diffuse fibrillary
glioma, a p53 LI of > 1% appears to favor the diagnosis of
diffuse astrocytoma.},
Key = {fds132130}
}
@article{fds132163,
Author = {H Kassem-Moussa and JM Provenzale, JR Petrella and DV
Lewis},
Title = {Early diffusion-weighted MR imaging abnormalities in
sustained seizure activity.},
Journal = {AJR. American journal of roentgenology},
Volume = {174},
Number = {5},
Pages = {1304-6},
Year = {2000},
Month = {May},
ISSN = {0361-803X},
Keywords = {Brain • Child • Epilepsies, Partial • Female
• Humans • Magnetic Resonance Imaging* •
diagnosis* • pathology • pathology*},
Language = {eng},
Key = {fds132163}
}
@article{fds132166,
Author = {JC Wong and JM Provenzale, JR Petrella},
Title = {Perfusion MR imaging of brain neoplasms.},
Journal = {AJR. American journal of roentgenology, UNITED
STATES},
Volume = {174},
Number = {4},
Pages = {1147-57},
Year = {2000},
Month = {April},
ISSN = {0361-803X},
Keywords = {Adult • Aged • Brain Neoplasms • Female
• Humans • Magnetic Resonance Imaging • Male
• Middle Aged • Perfusion • methods* •
pathology*},
Key = {fds132166}
}
@article{fds132171,
Author = {JM Provenzale and U Ali and DP Barboriak and DF Kallmes and DM Delong and RE McLendon},
Title = {Comparison of patient age with MR imaging features of
gangliogliomas.},
Journal = {AJR. American journal of roentgenology, UNITED
STATES},
Volume = {174},
Number = {3},
Pages = {859-62},
Year = {2000},
Month = {March},
ISSN = {0361-803X},
Keywords = {Adolescent • Adult • Age Factors • Brain
• Brain Edema • Brain Neoplasms • Child
• Child, Preschool • Female • Ganglioglioma
• Humans • Image Enhancement • Infant •
Magnetic Resonance Imaging* • Male • Middle Aged
• Sensitivity and Specificity • diagnosis •
diagnosis* • pathology},
Abstract = {OBJECTIVE: The purpose of this study was to compare MR
imaging features of gangliogliomas in children less than 10
years old with those seen in patients at least 10 years old.
MATERIALS AND METHODS: Our study population consisted of 15
female patients and 10 male patients with a mean age of 20
years. The early childhood group was composed of six
children with a mean age of 5.5 years. The older group was
composed of 19 patients with a mean age of 25.6 years. We
assessed tumor volume, tumor location, percentage of tumor
that was cystic, pattern of contrast enhancement, and degree
of edema. RESULTS: The temporal lobe was the most common
tumor location in both groups. Mean tumor volume in the
early childhood group was 83 cm3, which was significantly
larger than the mean tumor volume (9.78 cm3) for the older
group (p = 0.001). Cystic tumors were more common in the
early childhood group (83%) than in the older group (63%),
and the average percentage of cysts in the cystic tumors was
much higher in the early childhood group (67%) than in the
older group (30%). Contrast enhancement was seen in five of
six early childhood tumors and 13 of 16 tumors in older
patients. Four of six tumors in the early childhood group
and five of 19 tumors in the older patient group had
associated edema. CONCLUSION: The mean tumor volume of
gangliogliomas in the early childhood group was
significantly larger than that of the older patient group.
This finding may be indicative of differences in tumor
growth patterns in the two groups, ability of the
hemicranium to adjust to mass effect in childhood, or
sampling error as a result of a relatively small sample
size.},
Key = {fds132171}
}
@article{fds132174,
Author = {G Akabani and I Cokgor and RE Coleman and D González Trotter and TZ
Wong, HS Friedman and AH Friedman and A Garcia-Turner and JE Herndon and D DeLong and RE McLendon and XG Zhao and CN Pegram and JM Provenzale and DD
Bigner, MR Zalutsky},
Title = {Dosimetry and dose-response relationships in newly diagnosed
patients with malignant gliomas treated with
iodine-131-labeled anti-tenascin monoclonal antibody 81C6
therapy.},
Journal = {International journal of radiation oncology, biology,
physics},
Volume = {46},
Number = {4},
Pages = {947-58},
Year = {2000},
Month = {March},
ISSN = {0360-3016},
Keywords = {Antibodies, Monoclonal • Brain Neoplasms •
Dose-Response Relationship, Radiation • Female •
Glioma • Humans • Iodine Radioisotopes •
Magnetic Resonance Imaging • Male • Middle Aged
• Radioimmunotherapy • Tenascin • immunology*
• methods* • radiotherapy* • therapeutic
use*},
Abstract = {OBJECTIVE: The objective of this study was to perform the
dosimetry and evaluate the dose-response relationships in
newly diagnosed patients with malignant brain tumors treated
by direct injections of (131)I-labeled 81C6 monoclonal
antibody (MAb) into surgically created resection cavities
(SCRCs). METHODS: Absorbed doses to the 2-cm-thick shell as
measured from the margins of the resection cavity interface
were estimated for 42 patients with primary brain tumors. MR
images were used to assess the enhanced-rim volume as a
function of time after radiolabeled MAb therapy. Biopsy
samples were obtained from 15 patients and 1 autopsy.
RESULTS: The average absorbed dose [range] to the 2-cm shell
region was 32 [3-59] Gy. For the endpoint of minimal time to
MR contrast enhancement, the optimal absorbed dose and
initial dose-rate were 43 +/- 16 Gy and 0. 41 +/- 0.10 Gy/h,
respectively. There was a correlation between the absorbed
dose and dose rate to the shell region and biopsy outcome
(tumor recurrence, radionecrosis, and tumor recurrence
and/or radionecrosis). In this Phase I study, the maximum
tolerated dose (MTD) was 120 mCi. At this MTD, the estimated
average absorbed dose and initial dose rate to the 2-cm
shell were 41 [9-89] Gy and 0.51 [0.24-1.13] Gy/h,
respectively. These values are in agreement with the optimal
values based on the time to MR lesion rim enhancement.
CONCLUSIONS: The average absorbed dose to the 2-cm shell
region varied considerably and mainly depended on cavity
volume. In future clinical trials, the administered activity
of (131)I-labeled 81C6 MAb may be adjusted based on cavity
volume in order to deliver the optimal absorbed dose of 43
Gy rather than giving a fixed administered
activity.},
Language = {eng},
Key = {fds132174}
}
@article{fds132175,
Author = {JM Provenzale},
Title = {Centennial dissertation. Honoring Arthur W. Goodspeed, MD
and James B. Bullitt, MD. CT and MR imaging and nontraumatic
neurologic emergencies.},
Journal = {AJR. American journal of roentgenology, UNITED
STATES},
Volume = {174},
Number = {2},
Pages = {289-99},
Year = {2000},
Month = {February},
ISSN = {0361-803X},
Keywords = {Aneurysm, Dissecting • Brain Diseases • Carotid
Arteries • Emergencies • Encephalitis, Herpes
Simplex • Humans • Hypertensive Encephalopathy
• Magnetic Resonance Imaging* • Sinus Thrombosis,
Intracranial • Tomography, X-Ray Computed* •
Vertebral Artery • diagnosis •
diagnosis*},
Abstract = {This review has highlighted some of the disease processes
that produce diagnostic difficulty in the emergency
neuroradiology setting. Because radiologists are often the
first individuals to consider these entities, they must be
familiar with the clinical features that suggest the
diagnosis. Furthermore, acquaintance with the various
imaging findings of these diseases will allow early
diagnosis and will help limit the severe complications that
follow these neurologic emergency conditions if left
untreated.},
Key = {fds132175}
}
@article{fds131984,
Title = {Ahearn EP, Steffens DC, Cassidy F, Van Meter S , Provenzale
JM, Weisler RH, Krishnan KR. Dr. Ahearn and colleagues reply
Am J Psychiatry. 2000 Feb;157(2):307.},
Year = {2000},
Key = {fds131984}
}
@article{fds131996,
Author = {ST Engelter and JM Provenzale, JR Petrella and MJ
Alberts},
Title = {Diffusion MR imaging and transient ischemic
attacks.},
Journal = {Stroke; a journal of cerebral circulation, UNITED
STATES},
Volume = {30},
Number = {12},
Pages = {2762-3},
Year = {1999},
Month = {December},
ISSN = {0039-2499},
Keywords = {Female • Humans • Ischemic Attack, Transient
• Magnetic Resonance Imaging • Male • Middle
Aged • Remission, Spontaneous • Time Factors
• diagnosis* • methods*},
Key = {fds131996}
}
@article{fds132117,
Author = {ST Engelter, JR Petrella and MJ Alberts and JM
Provenzale},
Title = {Assessment of cerebral microcirculation in a patient with
hypertensive encephalopathy using MR perfusion
imaging.},
Journal = {AJR. American journal of roentgenology, UNITED
STATES},
Volume = {173},
Number = {6},
Pages = {1491-3},
Year = {1999},
Month = {December},
ISSN = {0361-803X},
Keywords = {Adult • Blood Flow Velocity • Brain • Brain
Edema • Cerebral Cortex • Echo-Planar Imaging*
• Female • Humans • Hypertensive
Encephalopathy • Image Enhancement* • Image
Processing, Computer-Assisted • Microcirculation •
Regional Blood Flow • blood supply • blood supply*
• diagnosis • diagnosis* • pathology •
physiology • physiopathology},
Key = {fds132117}
}
@article{fds132118,
Author = {JM Provenzale and AG Sorensen},
Title = {Diffusion-weighted MR imaging in acute stroke: theoretic
considerations and clinical applications.},
Journal = {AJR. American journal of roentgenology, UNITED
STATES},
Volume = {173},
Number = {6},
Pages = {1459-67},
Year = {1999},
Month = {December},
ISSN = {0361-803X},
Keywords = {Acute Disease • Brain • Cerebrovascular Accident
• Diffusion • Humans • Image Enhancement*
• Image Processing, Computer-Assisted • Magnetic
Resonance Imaging* • Sensitivity and Specificity •
diagnosis* • pathology},
Abstract = {The major clinical use of diffusion-weighted imaging to date
has been in evaluation of cerebral infarction, at which it
excels. However, diffusion-weighted imaging has also shown
promise for other applications, ranging from quantitative
analysis of biologic changes that are not apparent from
simple visual inspection of images (but are detectable after
using regions of interest on apparent diffusion coefficient
maps) to better characterization of other intracranial
abnormalities (e.g., abscess and tumor). Both the clinical
and research applications of diffusion-weighted imaging can
be expected to increase, providing fresh insights into
physiologic characteristics of both normal and abnormal
tissue.},
Key = {fds132118}
}
@article{fds131999,
Author = {JM Provenzale},
Title = {Nontraumatic neurologic emergencies: imaging findings and
diagnostic pitfalls.},
Journal = {Radiographics : a review publication of the Radiological
Society of North America, Inc},
Volume = {19},
Number = {5},
Pages = {1323-31},
Year = {1999},
Month = {October},
ISSN = {0271-5333},
Keywords = {Acute Disease • Adult • Aged • Aneurysm,
Dissecting • Brain • Cerebral Infarction •
Cerebrovascular Disorders • Child, Preschool •
Emergencies • Female • Humans • Intracranial
Aneurysm • Magnetic Resonance Imaging • Male
• Middle Aged • Sinus Thrombosis, Intracranial
• Tomography, X-Ray Computed • diagnosis •
diagnosis* • pathology • radiography},
Language = {eng},
Key = {fds131999}
}
@article{fds132172,
Author = {DP Barboriak and JM Provenzale, JR MacFall},
Title = {White matter lesion contrast in fast spin-echo
fluid-attenuated inversion recovery imaging: effect of
varying effective echo time and echo train
length.},
Journal = {AJR. American journal of roentgenology, UNITED
STATES},
Volume = {173},
Number = {4},
Pages = {1091-6},
Year = {1999},
Month = {October},
ISSN = {0361-803X},
Keywords = {Brain • Brain Diseases • Female • Humans
• Image Processing, Computer-Assisted • Magnetic
Resonance Imaging • Male • Middle Aged •
Prospective Studies • Signal Processing,
Computer-Assisted • diagnosis* • methods* •
pathology*},
Abstract = {OBJECTIVE: Our aim was to determine whether the contrast
between white matter lesions and normal-appearing white
matter in fast spin-echo fluid-attenuated inversion recovery
(FLAIR) images can be improved by lengthening the effective
TE and the echo train length. SUBJECTS AND METHODS: Thirty
patients with various white matter lesions were imaged using
fast spin-echo FLAIR sequences (TR = 10,002 msec; inversion
time = 2200) on a 1.5-T MR imaging system. For 14 patients,
fast spin-echo FLAIR sequences with a TE of 165 msec and
echo train length of 32 (fast spin-echo FLAIR 165/32) were
compared with fast spin-echo FLAIR sequences with a TE of
125 msec and echo train length of 24 (fast spin-echo FLAIR
125/24). For 16 other patients, fast spin-echo FLAIR 165/32
sequences were compared with fast spin-echo FLAIR sequences
with a TE of 145 msec and echo train length of 28 (fast
spin-echo FLAIR 145/28). Signal difference-to-noise ratios
were calculated between the lesions and normal-appearing
white matter for a typical lesion in each patient. RESULTS:
In both groups, a small but statistically significant
increase in the signal difference-to-noise ratio was found
on the fast spin-echo FLAIR sequences using the longer TE
and echo train length. In the first group, signal
difference-to-noise ratio increased from 18.7 +/- 4.7 (mean
+/- SD) for fast spin-echo FLAIR 125/24 to 20.1 +/- 4.5 for
fast spin-echo FLAIR 165/32 (p < .05). In the second group,
the signal difference-to-noise ratio increased from 15.4 +/-
4.0 for fast spin-echo FLAIR 145/28 to 16.8 +/- 4.6 for fast
spin-echo FLAIR 165/32 (p <.01). In addition, fast spin-echo
FLAIR sequences with a longer TE and echo train length were
obtained more rapidly (6 min for fast spin-echo FLAIR
125/24, 5 min 20 sec for fast spin-echo FLAIR 145/28, and 4
min 41 sec for fast spin-echo FLAIR 165/32). CONCLUSION:
Lengthening the TE to 165 msec and echo train length to 32
in fast spin-echo FLAIR imaging allows both a mild
improvement in the contrast between white matter lesions and
normal-appearing white matter and shorter imaging
times.},
Key = {fds132172}
}
@article{fds132005,
Author = {DJ Madden and LR Gottlob and LL Denny and TG Turkington and JM
Provenzale, TC Hawk and RE Coleman},
Title = {Aging and recognition memory: changes in regional cerebral
blood flow associated with components of reaction time
distributions.},
Journal = {Journal of cognitive neuroscience, UNITED
STATES},
Volume = {11},
Number = {5},
Pages = {511-20},
Year = {1999},
Month = {September},
ISSN = {0898-929X},
Keywords = {Adult • Aged • Aging • Brain • Brain
Mapping • Cerebrovascular Circulation* • Female
• Humans • Language • Male • Memory
• Mental Recall • Middle Aged • Prefrontal
Cortex • Reaction Time* • Regression Analysis
• Statistical Distributions • Tomography,
Emission-Computed • Visual Perception • blood
supply • physiology • physiology* •
radionuclide imaging},
Abstract = {We used H(2)15O positron emission tomography (PET) to
measure age-related changes in regional cerebral blood flow
(rCBF) during a verbal recognition memory task. Twelve young
adults (20 to 29 years) and 12 older adults (62 to 79 years)
participated. Separate PET scans were conducted during
Encoding, Baseline, and Retrieval conditions. Each of the
conditions involved viewing a series of 64 words and making
a two-choice response manually. The complete reaction time
(RT) distributions in each task condition were characterized
in terms of an ex-Gaussian model (convolution of exponential
and Gaussian functions). Parameter estimates were obtained
for the mean of the exponential component (tau),
representing a task-specific decision process and the mean
of the Gaussian component (mu) representing residual sensory
coding and response processes. Independently of age group,
both tau and mu were higher in the Encoding and Retrieval
conditions than in the Baseline condition, and tau was
higher during Retrieval than during Encoding. Age-related
slowing in task performance was evident primarily in mu. For
young adults, rCBF activation in the right prefrontal
cortex, in the Retrieval condition, was correlated
positively with mu but not with tau. For older adults, rCBF
changes (both increases and decreases) in several cortical
regions were correlated with both mu and tau. The data
suggest that the attentional demands of this task are
relatively greater for older adults and consequently lead to
the recruitment of additional neural systems during task
performance.},
Key = {fds132005}
}
@article{fds132109,
Author = {JM Provenzale and NJ Beauchamp Jr},
Title = {Recent advances in imaging of cerebrovascular
disease.},
Journal = {Radiologic clinics of North America},
Volume = {37},
Number = {3},
Pages = {467-88},
Year = {1999},
Month = {May},
ISSN = {0033-8389},
Keywords = {Cerebral Infarction • Cerebrovascular Disorders •
Emergencies • Humans • Magnetic Resonance Imaging
• Sinus Thrombosis, Intracranial • Tomography,
X-Ray Computed • diagnosis • diagnosis* •
methods • radiography},
Abstract = {The recent advances made in CT and MR imaging have led to
increased accuracy in making a number of diagnoses in the
emergency room setting. Increasingly, radiologists are asked
to perform these studies and accurately interpret the
findings, which often have a dramatic impact on triaging and
treatment of the patient. Future trials need to address
further the relative merits of each of the techniques
outlined previously in specific settings. In addition, given
the increasing number of means of obtaining diagnostic
information, cost effectiveness studies are needed to better
formulate an appropriate algorithm for each
diagnosis.},
Language = {eng},
Key = {fds132109}
}
@article{fds132115,
Author = {HS Friedman and WP Petros and AH Friedman and LJ Schaaf and T Kerby and J
Lawyer, M Parry and PJ Houghton and S Lovell and K Rasheed and T
Cloughsey, ES Stewart and OM Colvin and JM Provenzale and RE
McLendon, DD Bigner and I Cokgor and M Haglund and J Rich and D Ashley and J Malczyn and GL Elfring and LL Miller},
Title = {Irinotecan therapy in adults with recurrent or progressive
malignant glioma.},
Journal = {Journal of clinical oncology : official journal of the
American Society of Clinical Oncology},
Volume = {17},
Number = {5},
Pages = {1516-25},
Year = {1999},
Month = {May},
ISSN = {0732-183X},
Keywords = {Adult • Aged • Antineoplastic Agents, Phytogenic
• Astrocytoma • Brain Neoplasms •
Camptothecin • Disease Progression • Female •
Glioblastoma • Glioma • Humans • Male •
Middle Aged • Neoplasm Recurrence, Local •
Oligodendroglioma • analogs & derivatives* • blood
• drug therapy • drug therapy* •
pharmacokinetics • therapeutic use • therapeutic
use*},
Abstract = {OBJECTIVE: To determine the activity, toxicity, and
pharmacokinetics of irinotecan (CPT-11, Camptosar; Pharmacia
& Upjohn, Kalamazoo, MI) in the treatment of adults with
progressive, persistent, or recurrent malignant glioma.
METHODS: Patients with progressive or recurrent malignant
gliomas were enrolled onto this study between October 1996
and August 1997. CPT-11 was given as a 90-minute intravenous
(i.v.) infusion at a dose of 125 mg/m2 once weekly for 4
weeks followed by a 2-week rest, which comprised one course.
Plasma concentrations of CPT-11 and its metabolites, SN-38
and SN-38 glucuronide (SN-38G), were determined in a subset
of patients. RESULTS: All 60 patients who enrolled (36 males
and 24 females) were treated with CPT-11 and all were
assessable for toxicity, response, and survival.
Pharmacokinetic data were available in 32 patients. Nine
patients (15%; 95% confidence interval, 6% to 24%) had a
confirmed partial response, and 33 patients (55%) achieved
stable disease lasting more than two courses (12 weeks).
Toxicity observed during the study was limited to infrequent
neutropenia, nausea, vomiting, and diarrhea. CPT-11, SN-38,
and SN-38G area under the plasma concentration-time curves
through infinite time values in these patients were
approximately 40%, 25%, and 25%, respectively, of those
determined previously in patients with metastatic colorectal
cancer not receiving antiepileptics or chronic dexamethasone
treatment. CONCLUSIONS: Response results document that
CPT-11, given with a standard starting dose and treatment
schedule, has activity in patients with recurrent malignant
glioma. However, the low incidence of severe toxicity and
low plasma concentrations of CPT-11 and SN-38 achieved in
this patient population suggest that concurrent treatment
with anticonvulsants and dexamethasone enhances drug
clearance.},
Language = {eng},
Key = {fds132115}
}
@article{fds131981,
Author = {RC Dash and JM Provenzale and RD McComb and DA Perry and DC Longee and RE
McLendon},
Title = {Malignant supratentorial ganglioglioma (ganglion cell-giant
cell glioblastoma): a case report and review of the
literature.},
Journal = {Archives of pathology & laboratory medicine},
Volume = {123},
Number = {4},
Pages = {342-5},
Year = {1999},
Month = {April},
ISSN = {0003-9985},
url = {http://dx.doi.org/10.1043/0003-9985(1999)123<0342:MSGGCG>2.0.CO;2},
Keywords = {Brain Neoplasms • Child • Female •
Ganglioglioma • Glioblastoma • Humans •
Tomography, X-Ray Computed • pathology* •
radiography},
Abstract = {BACKGROUND: From both epidemiologic and pathologic
viewpoints, gangliogliomas exhibiting components of giant
cell glioblastomas are extraordinary neoplasms. We report
herein the case of a 6-year-old girl who presented initially
with a World Health Organization grade IV anaplastic
ganglioglioma (a mixed ganglion cell tumor-giant cell
glioblastoma). Despite aggressive management, the patient
died of disease in a relatively short period. METHODS:
Formalin-fixed, paraffin-embedded tissue blocks were
sectioned at 5 microm for histochemical and
immunohistochemical analyses. Hematoxylin-eosin-stained
sections and immunohistochemically stained sections from the
primary and secondary resections were reviewed. Reactivity
for glial fibrillary acidic protein, neurofilament protein,
synaptophysin, and Ki67 nuclear antigen was evaluated.
RESULTS: Histologically, 2 distinct cell populations were
noted on both the primary and secondary resections. The
primary resection revealed a neoplasm having a predominant
glial component consistent with a glioblastoma. Interspersed
were dysmorphic ganglion cells supporting a diagnosis of
ganglioglioma. The second resection (following therapy)
demonstrated a much more prominent dysmorphic ganglion cell
component and a subdued glial component. CONCLUSIONS:
Although immunohistochemical analysis clearly distinguished
the 2 tumor cell populations, the identification of Nissl
substance in neurons proved to be equally helpful. Although
other cases of grade III gangliogliomas and rare cases of
grade IV gangliogliomas have been reported, the present case
is exceptional in that, to our knowledge, it is the only
report of a patient who presented initially with a composite
grade IV ganglioglioma and who was clinically followed up to
the time of death. This case allows direct comparison
between the histologic findings in a giant cell glioblastoma
and a ganglioglioma and documents the aggressive biologic
behavior of this complex neoplasm.},
Language = {eng},
Doi = {10.1043/0003-9985(1999)123<0342:MSGGCG>2.0.CO;2},
Key = {fds131981}
}
@article{fds132173,
Author = {JM Provenzale and MA Arata and TG Turkington and RE McLendon and RE
Coleman},
Title = {Gangliogliomas: characterization by registered positron
emission tomography-MR images.},
Journal = {AJR. American journal of roentgenology},
Volume = {172},
Number = {4},
Pages = {1103-7},
Year = {1999},
Month = {April},
ISSN = {0361-803X},
Keywords = {Adolescent • Adult • Brain Neoplasms • Child
• Child, Preschool • Female •
Fluorodeoxyglucose F18 • Ganglioglioma • Humans
• Infant • Magnetic Resonance Imaging* • Male
• Radiopharmaceuticals • Tomography,
Emission-Computed* • diagnosis* • diagnostic use
• metabolism • radionuclide imaging},
Abstract = {OBJECTIVE: The purpose of this study was to correlate
18F-fluorodeoxyglucose positron emission tomography (PET)
and MR imaging features of cerebral gangliogliomas before
and after PET-MR image registration. CONCLUSION: After
registration of PET and MR images, all six gangliogliomas in
our series were shown to have heterogeneous metabolic
activity. Areas of hypermetabolic activity were seen in all
lesions. In five of the six cases, PET-MR image registration
provided information regarding tumor metabolism that was not
available on nonregistered hard-copy examinations.},
Language = {eng},
Key = {fds132173}
}
@article{fds132007,
Author = {JM Provenzale and ST Engelter, JR Petrella and JS Smith, JR
MacFall},
Title = {Use of MR exponential diffusion-weighted images to eradicate
T2 "shine-through" effect.},
Journal = {AJR. American journal of roentgenology},
Volume = {172},
Number = {2},
Pages = {537-9},
Year = {1999},
Month = {February},
ISSN = {0361-803X},
Keywords = {Aged • Brain • Cerebral Infarction • Female
• Humans • Magnetic Resonance Imaging • Male
• Middle Aged • Retrospective Studies •
methods* • pathology*},
Language = {eng},
Key = {fds132007}
}
@article{fds132145,
Author = {DJ Madden and TG Turkington and JM Provenzale and LL Denny and TC Hawk and LR Gottlob and RE Coleman},
Title = {Adult age differences in the functional neuroanatomy of
verbal recognition memory.},
Journal = {Human brain mapping, UNITED STATES},
Volume = {7},
Number = {2},
Pages = {115-35},
Year = {1999},
ISSN = {1065-9471},
Keywords = {Adult • Aged • Aging • Brain •
Cerebrovascular Circulation • Discrimination
(Psychology) • Female • Humans • Language*
• Male • Memory • Middle Aged • Observer
Variation • Reaction Time • Tomography,
Emission-Computed* • physiology • physiology*
• radionuclide imaging*},
Abstract = {Adult age differences are frequently observed in the
performance of memory tasks, but the changes in neural
function mediating these differences are largely unknown. We
used (H2)15O positron emission tomography (PET) to measure
changes in regional cerebral blood flow (rCBF) during
Encoding, Baseline, and Retrieval conditions of a
recognition memory task. Twelve young adults (20-29 years)
and 12 older adults (62-79 years) participated. During each
task condition, participants made a two-choice manual
response to each of 64 words. Analyses of the performance
data yielded evidence of age-related slowing of encoding and
retrieval processes, and an age-related decline in the
accuracy of yes/no recognition (d'). The rCBF activation
associated with both encoding and retrieval was greater for
older adults than for young adults, but this pattern was
more clearly evident for memory retrieval. For young adults,
rCBF activation during retrieval occurred primarily in right
prefrontal cortex, whereas older adults exhibited a more
bilateral pattern of prefrontal activation. Regression
analyses predicting reaction time in the memory task from
regional PET counts confirmed that the neural system
mediating memory retrieval is more widely distributed for
older adults than for young adults. Both age groups
exhibited some decrease in rCBF activation in the second
half of the test session, relative to the first half. The
practice-related decrease in rCBF activation was more
prominent for young adults, suggesting that the older
adults' recruitment of additional neural systems reflects a
more continual allocation of attention to support task
performance.},
Key = {fds132145}
}
@article{fds132184,
Author = {JW IJdo and AM Conti-Kelly and P Greco and M Abedi and M Amos and JM
Provenzale, TP Greco},
Title = {Anti-phospholipid antibodies in patients with multiple
sclerosis and MS-like illnesses: MS or APS?},
Journal = {Lupus, ENGLAND},
Volume = {8},
Number = {2},
Pages = {109-15},
Year = {1999},
ISSN = {0961-2033},
Keywords = {Adolescent • Adult • Antibodies, Antiphospholipid
• Antiphospholipid Syndrome • Diagnosis,
Differential • Female • Humans • Incidence
• Lupus Coagulation Inhibitor • Male • Middle
Aged • Multiple Sclerosis • Optic Neuritis •
Prospective Studies • Seroepidemiologic Studies •
blood • blood* • diagnosis • diagnosis*
• epidemiology • immunology •
immunology*},
Abstract = {OBJECTIVE: To describe the frequency, clinical, and
laboratory features of patients diagnosed with multiple
sclerosis (MS) or MS-like illnesses (MSL) among a large,
prospectively followed cohort of anti-phospholipid antibody
(aPL)-positive patients. METHODS: Between 1990 and 1995
patients referred to a university-affiliated rheumatology
clinic were prospectively evaluated for aPL based on
questionnaires designed to detect aPL-related symptoms
and/or a family history of aPL-related illnesses. Magnetic
resonance imaging (MRI) was performed when significant
neurological features were present. A subgroup of all
patients diagnosed with MS or MSL was identified and their
clinical, laboratory, and imaging findings were reviewed.
RESULTS: Of 322 patients evaluated for aPL-related symptoms
or events, 189 (59%) were positive for at least one class of
aPL. Twenty-six of 322 patients (8%) carried a diagnosis of
MS or MSL, either at the initial evaluation or during the
study period. Twenty-three of the 26 individuals (88%)
tested positive for aPL, while the remaining 3 (11%) tested
repeatedly negative. Eighteen of the 23 patients (78%) had
either more than one class of aPL or had multiple positive
titers. IgM aCL was noted in 18 of the 23 patients (78%).
Oligoclonal bands were noted in five patients. Antinuclear
antibodies (ANA) and low complement levels were frequently
observed. Blinded MRI readings showed lesions consistent
with MS in the majority of cases. Clinically, 7 patients had
transverse myelitis (TM), while optic neuritis (ON) was
present in 8 patients. Most patients had either occult
symptoms of rheumatic disease or contributory family
histories. None had a defined underlying connective-tissue
disease. CONCLUSION: A substantial number of aPL-positive
patients have a concurrent diagnosis of MS or MSL,
frequently presenting with elevated IgM aCL, optic neuritis,
and transverse myelitis. The anti-phospholipid syndrome
(APS) should be strongly considered as an alternative
diagnosis to MS in these patients.},
Key = {fds132184}
}
@article{fds132159,
Author = {DP Barboriak and JM Provenzale},
Title = {MR arteriography of intracranial circulation.},
Journal = {AJR. American journal of roentgenology, UNITED
STATES},
Volume = {171},
Number = {6},
Pages = {1469-78},
Year = {1998},
Month = {December},
ISSN = {0361-803X},
Keywords = {Brain • Cerebrovascular Disorders • Humans •
Intracranial Aneurysm • Intracranial Arteriosclerosis
• Intracranial Arteriovenous Malformations •
Magnetic Resonance Angiography* • blood supply* •
diagnosis • diagnosis*},
Key = {fds132159}
}
@article{fds132170,
Author = {HS Friedman and RE McLendon and T Kerby and M Dugan and SH Bigner and AJ
Henry, DM Ashley and J Krischer and S Lovell and K Rasheed and F
Marchev, AJ Seman and I Cokgor and J Rich and E Stewart and OM Colvin and JM Provenzale and DD Bigner and MM Haglund and AH Friedman and PL
Modrich},
Title = {DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase
analysis and response to Temodal in newly diagnosed
malignant glioma.},
Journal = {Journal of clinical oncology : official journal of the
American Society of Clinical Oncology},
Volume = {16},
Number = {12},
Pages = {3851-7},
Year = {1998},
Month = {December},
ISSN = {0732-183X},
Keywords = {Adult • Aged • Antineoplastic Agents, Alkylating
• Brain Neoplasms • DNA Repair • DNA,
Neoplasm • Dacarbazine* • Drug Administration
Schedule • Female • Glioblastoma • Humans
• Imidazoles • Male • Middle Aged •
O(6)-Methylguanine-DNA Methyltransferase • Predictive
Value of Tests • Treatment Outcome •
administration & dosage • analogs & derivatives* •
drug effects* • drug therapy* • enzymology* •
genetics • genetics* • therapeutic
use*},
Abstract = {OBJECTIVE: We evaluated the response to Temodal
(Schering-Plough Research Institute, Kenilworth, NJ) of
patients with newly diagnosed malignant glioma, as well as
the predictive value of quantifying tumor DNA mismatch
repair activity and O6-alkylguanine-DNA alkyltransferase
(AGT). METHODS: Thirty-three patients with newly diagnosed
glioblastoma multiforme (GBM) and five patients with newly
diagnosed anaplastic astrocytoma (AA) were treated with
Temodal at a starting dose of 200 mg/m2 daily for 5
consecutive days with repeat dosing every 28 days after the
first daily dose. Immunochemistry for the detection of the
human DNA mismatch repair proteins MSH2 and MLH1 and the DNA
repair protein AGT was performed with monoclonal antibodies
and characterized with respect to percent positive staining.
RESULTS: Of the 33 patients with GBM, complete responses
(CRs) occurred in three patients, partial responses (PRs)
occurred in 14 patients, stable disease (SD) was seen in
four patients, and 12 patients developed progressive disease
(PD). Toxicity included infrequent grades 3 and 4
myelosuppression, constipation, nausea, and headache. Thirty
tumors showed greater than 60% cells that stained for MSH2
and MLH1, with three CRs, 12 PRs, three SDs, and 12 PDs.
Eight tumors showed 60% or less cells that stained with
antibodies to MSH2 and/or MLH1, with 3 PRs, 3 SDs, and 2
PDs. Eleven tumors showed 20% or greater cells that stained
with an antibody to AGT, with 1 PR, 2 SDs, and 8 PDs.
Twenty-five tumors showed less than 20% cells that stained
for AGT, with 3 CRs, 12 PRs, 4 SDs, and 6 PDs. CONCLUSIONS:
These results suggest that Temodal has activity against
newly diagnosed GBM and AA and warrants continued evaluation
of this agent. Furthermore, pretherapy analysis of tumor DNA
mismatch repair and, particularly, AGT protein expression
may identify patients in whom tumors are resistant to
Temodal.},
Language = {eng},
Key = {fds132170}
}
@article{fds132108,
Author = {EP Ahearn and DC Steffens and F Cassidy and SA Van Meter and JM
Provenzale, MF Seldin and RH Weisler and KR Krishnan},
Title = {Familial leukoencephalopathy in bipolar disorder.},
Journal = {The American journal of psychiatry},
Volume = {155},
Number = {11},
Pages = {1605-7},
Year = {1998},
Month = {November},
ISSN = {0002-953X},
Keywords = {Adolescent • Adult • Age of Onset • Aged
• Bipolar Disorder • Brain • Brain Diseases
• Child • Comorbidity • Depressive Disorder
• Family* • Genetic Markers • Humans •
Magnetic Resonance Imaging* • Middle Aged •
Pedigree • epidemiology • epidemiology* •
genetics • genetics* • pathology},
Abstract = {OBJECTIVE: Imaging studies of patients with bipolar disorder
demonstrate changes in deep white matter and subcortical
gray nuclei that are seen as focal hyperintensities on
T2-weighted magnetic resonance imaging (MRI). The objective
of this study was to examine MRIs in a family with a strong
history of bipolar disorder to look for possible MRI
abnormalities in members with and without affective illness.
METHODS: The authors obtained MRIs of 21 members of a family
with a strong history of bipolar disorder. Eight of the
family members studied had bipolar illness, one had symptoms
of bipolar disorder but did not meet full DSM-III-R
criteria, two had unipolar disorder, and 10 did not have
bipolar disorder. RESULTS: Fifteen of the 21 family members
had MRI findings, including six of 10 family members who had
no affective disorder and all of those with bipolar
disorder. Lesions of both white matter and subcortical gray
nuclei were found. CONCLUSIONS: Although the clinical
significance of these MRI findings is unknown, the high
prevalence of MRI findings in both affected and unaffected
family members suggests that MRI findings may potentially
serve as a biological marker for bipolar disorder. Recent
genetic studies have established a link between familial
leukoencephalopathy and chromosome 19. If
leukoencephalopathy appears to be related to bipolar
disorder, it may allow clearer characterization of the
genetics of the disorder.},
Language = {eng},
Key = {fds132108}
}
@article{fds131982,
Author = {JM Provenzale and DP Frush and TL Ortel},
Title = {Recurrent thrombosis of the superior vena cava associated
with activated protein C resistance: imaging
findings.},
Journal = {Pediatric radiology, GERMANY},
Volume = {28},
Number = {8},
Pages = {597-8},
Year = {1998},
Month = {August},
ISSN = {0301-0449},
Keywords = {Blood Coagulation Disorders • Catheters, Indwelling
• Echocardiography • Humans • Infant, Newborn
• Magnetic Resonance Imaging • Male •
Plasminogen Activators • Protein C • Recurrence
• Risk Factors • Thrombophlebitis • Urinary
Plasminogen Activator • Vena Cava, Superior* •
adverse effects • drug therapy • etiology* •
genetics • physiology* • physiopathology* •
therapeutic use},
Abstract = {The purpose of this report is to describe imaging findings
in activated protein C resistance, a hereditary cause of
recurrent thrombosis. The case described was unusual in that
a neonate was affected, whereas the vast majority of cases
occur in adulthood. This entity is important to diagnose
because of the recurrent nature of thromboses and the fact
that relatives are often affected.},
Key = {fds131982}
}
@article{fds131969,
Author = {MA Arata and JM Provenzale and JJ Vredenburgh},
Title = {Cytomegalovirus encephalomyelitis: MR imaging findings
documenting response to ganciclovir therapy.},
Journal = {AJR. American journal of roentgenology},
Volume = {171},
Number = {1},
Pages = {103-5},
Year = {1998},
Month = {July},
ISSN = {0361-803X},
Keywords = {Antineoplastic Combined Chemotherapy Protocols •
Antiviral Agents • Breast Neoplasms •
Cytomegalovirus Infections • Encephalomyelitis •
Female • Ganciclovir • Humans •
Immunocompromised Host • Magnetic Resonance Imaging
• Middle Aged • diagnosis • drug therapy
• drug therapy* • immunology • therapeutic
use • therapeutic use* • virology*},
Language = {eng},
Key = {fds131969}
}
@article{fds132176,
Author = {G Bennett and JM Provenzale},
Title = {Schistosomal myelitis: findings at MR imaging.},
Journal = {European journal of radiology, IRELAND},
Volume = {27},
Number = {3},
Pages = {268-70},
Year = {1998},
Month = {July},
ISSN = {0720-048X},
Keywords = {Adult • Humans • Magnetic Resonance Imaging*
• Male • Myelitis • Schistosomiasis mansoni
• Spinal Cord • diagnosis* •
pathology},
Abstract = {Schistosomal spinal cord involvement is a rare complication
of infection by Schistosoma mansoni. This work reports the
MR imaging findings in a patient with schistosomal myelitis
involving the lower spinal cord and conus medullaris. MR
imaging showed a focal mass with a slightly nodular surface
and which had peripheral enhancement after contrast
administration. The MR appearance of this complication of
schistosomal infection is important to recognize so that
early medical therapy can be started in an attempt to
maximize neurologic recovery.},
Key = {fds132176}
}
@article{fds132158,
Author = {JM Provenzale and DP Barboriak and RE Coleman},
Title = {Limbic encephalitis: comparison of FDG PET and MR imaging
findings.},
Journal = {AJR. American journal of roentgenology},
Volume = {170},
Number = {6},
Pages = {1659-60},
Year = {1998},
Month = {June},
ISSN = {0361-803X},
Keywords = {Amygdala* • Delusions • Encephalitis • Female
• Fluorodeoxyglucose F18 • Hippocampus* •
Humans • Magnetic Resonance Imaging* • Memory
Disorders • Middle Aged • Paraneoplastic Syndromes
• Tomography, Emission-Computed* • diagnosis
• diagnosis* • diagnostic use* •
etiology},
Language = {eng},
Key = {fds132158}
}
@article{fds132185,
Author = {DD Bigner and MT Brown and AH Friedman and RE Coleman and G Akabani and HS
Friedman, WL Thorstad and RE McLendon and SH Bigner and XG Zhao and CN
Pegram, CJ Wikstrand and JE Herndon and NA Vick and N Paleologos and I
Cokgor, JM Provenzale and MR Zalutsky},
Title = {Iodine-131-labeled antitenascin monoclonal antibody 81C6
treatment of patients with recurrent malignant gliomas:
phase I trial results.},
Journal = {Journal of clinical oncology : official journal of the
American Society of Clinical Oncology, UNITED
STATES},
Volume = {16},
Number = {6},
Pages = {2202-12},
Year = {1998},
Month = {June},
ISSN = {0732-183X},
Keywords = {Adolescent • Adult • Antibodies, Monoclonal •
Biopsy • Brain Neoplasms • Child • Female
• Glioma • Humans • Immunoassay •
Immunotherapy • Injections, Intralesional • Iodine
Radioisotopes • Magnetic Resonance Imaging • Male
• Middle Aged • Neoplasm Recurrence, Local •
Nervous System Diseases • Survival Rate • Tenascin
• Tomography, Emission-Computed • Treatment
Outcome • administration & dosage • adverse
effects • chemically induced • immunology •
immunology* • mortality • pathology •
therapeutic use* • therapy • therapy*},
Abstract = {PURPOSE: To determine the maximum-tolerated dose (MTD) of
iodine 131 (131I)-labeled 81C6 monoclonal antibody (mAb) in
brain tumor patients with surgically created resection
cavities (SCRCs) and to identify any objective responses to
this treatment. METHODS: In this phase I trial, eligible
patients were treated with a single injection of
131I-labeled 81C6. Cohorts of three to six patients were
treated with escalating dosages of 131I (starting dose of 20
mCi with a 20-mCi escalation in subsequent cohorts)
administered through an Ommaya reservoir in the SCRC.
Patients were followed up for toxicity and response until
death or for a minimum of 1 year after treatment. The SCRC
patients, who were previously irradiated, were followed up
without additional treatment unless progressive disease was
identified. RESULTS: We administered 36 treatments of 131I
doses up to 120 mCi to 34 previously irradiated patients
with recurrent or metastatic brain tumors. Dose-limiting
toxicity was reached at 120 mCi and was limited to
neurologic or hematologic toxicity. None of the patients
treated with less than 120 mCi developed significant
neurologic toxicity; one patient developed major hematologic
toxicity (MHT). The estimated median survival for patients
with glioblastoma multiforme (GBM) and for all patients was
56 and 60 weeks, respectively. CONCLUSION: The MTD for
administration of 131I-labeled 81C6 into the SCRCs of
previously irradiated patients with recurrent primary or
metastatic brain tumors was 100 mCi. The dose-limiting
toxicity was neurologic toxicity. We are encouraged by the
minimal toxicity and survival in this phase I trial.
Radiolabeled mAbs may improve the current therapy for brain
tumor patients.},
Key = {fds132185}
}
@article{fds132225,
Author = {A Moghrabi and HS Friedman and DM Ashley and KS Bottom and T Kerby and E
Stewart, C Bruggers and JM Provenzale and M Champagne and L Hershon and M Watral and J Ryan and K Rasheed and S Lovell and D Korones and H Fuchs and T
George, RE McLendon and AH Friedman and E Buckley and DC
Longee},
Title = {Phase II study of carboplatin (CBDCA) in progressive
low-grade gliomas.},
Journal = {Neurosurgical focus},
Volume = {4},
Number = {4},
Pages = {e3},
Year = {1998},
Month = {April},
ISSN = {1092-0684},
Abstract = {In this study, the authors sought to investigate the
response rate and toxicity of carboplatin in patients with
progressive low-grade glioma (LGG). Thirty-two patients with
progressive LGG were treated with carboplatin at a dosage of
560 mg/m(2). Treatment was given at 4-week intervals and
continued until the disease progressed, unacceptable
toxicity supervened, or for 12 additional courses after
achieving maximal response. Patients with stable disease
were treated with a total of 12 cycles. All patients were
treated as outpatients. Patients were evaluated for response
to treatment and toxicity. All patients received a minimum
of two cycles of carboplatin, and were examined for
response. A partial response was achieved in nine patients
(28%) and a minimal response in two (6%), for an overall
response rate of 34% (11 of 32 patients). Eighteen patients
(56%) had stable disease. A partial response was achieved in
the nine patients after a median of six cycles (range 4-11
cycles), a minimal response was achieved in the two patients
after five cycles. Glioma progression was noted in three
patients after three, five, and five cycles, respectively.
The 11 patients in whom some response was achieved had
either an optic pathway tumor or a juvenile pilocytic
astrocytoma. Twenty-six of the 32 patients had those
characteristics, making the response rate in that group 42%
(11 of 26 patients). Thirty-two patients received a total of
387 cycles of chemotherapy. Hematological toxicity was
moderate. Twenty-one patients developed thrombocytopenia
(platelet count < 50,000/microl); three patients required
one platelet transfusion each. Nine patients developed
neutropenia (absolute neutrophil count < 500/microl); one
developed fever and required administration of antibiotic
agents. One dose adjustment in each of the patients
prevented further thrombocytopenia and neutropenia. Two
patients with stable disease died of respiratory
complications. One patient developed Grade III ototoxicity
after receiving five cycles, one patient developed
hypersensitivity to carboplatin, and none developed
nephrotoxicity. Carboplatin given at a dosage of 560 mg/m(2)
every 4 weeks has activity in patients with progressive LGG.
This drug regimen is relatively simple and well tolerated.
Further investigation and longer follow-up study are
warranted.},
Language = {ENG},
Key = {fds132225}
}
@article{fds131971,
Author = {JM Provenzale and DP Barboriak and IC Davey and TL
Ortel},
Title = {Cerebrovascular disease risk factors: neuroradiologic
findings in patients with activated protein C
resistance.},
Journal = {Radiology, UNITED STATES},
Volume = {207},
Number = {1},
Pages = {85-9},
Year = {1998},
Month = {April},
ISSN = {0033-8419},
Keywords = {Adolescent • Adult • Aged • Blood Coagulation
• Brain • Cerebral Angiography • Cerebral
Infarction • Child • Echocardiography,
Transesophageal • Factor V • Female • Humans
• Intracranial Embolism and Thrombosis • Magnetic
Resonance Imaging • Male • Middle Aged •
Mutation • Protein C • Risk Factors •
Tomography, X-Ray Computed • blood • diagnosis
• diagnosis* • genetics • pathology •
physiology* • radiography},
Abstract = {PURPOSE: To assess the patterns of abnormal neuroradiologic
findings in patients with a hypercoagulable state related to
activated protein C (APC) resistance. MATERIALS AND METHODS:
Records in 23 patients with a hypercoagulable state related
to APC resistance (18 women, five men; average age, 44.5
years) were reviewed for cerebrovascular disease risk
factors and other causes of a hypercoagulable state.
Computed tomographic scans, magnetic resonance (MR) images,
angiograms, and transesophageal echocardiograms were also
reviewed. RESULTS: Stroke risk factors or other causes of a
hypercoagulable state were found in 12 patients. Arterial
infarcts were seen in 18 patients. Hyperintense white matter
foci were seen on MR images in six patients. Dural sinus
thrombosis was found in four patients. Angiograms of
intracranial circulation in six patients showed major artery
occlusions in four. MR angiograms in four patients showed
internal carotid artery occlusion in one. No major
abnormalities were seen in extracranial cerebral vasculature
in 15 patients. Transesophageal echocardiograms in 11
patients showed a patent foramen ovale in one patient but no
systemic source of embolism. Seven patients had non-central
nervous system thrombotic events. CONCLUSION: Patients with
APC resistance and stroke appear to differ from the general
stroke population in terms of age and frequency of
extracranial sources of cerebrovascular disease.},
Key = {fds131971}
}
@article{fds131973,
Author = {JM Provenzale and DP Barboriak and NB Allen and TL
Ortel},
Title = {Antiphospholipid antibodies: findings at
arteriography.},
Journal = {AJNR. American journal of neuroradiology},
Volume = {19},
Number = {4},
Pages = {611-6},
Year = {1998},
Month = {April},
ISSN = {0195-6108},
Keywords = {Adult • Antibodies, Antiphospholipid • Arterial
Occlusive Diseases • Basilar Artery • Brain
Ischemia • Cerebral Angiography* • Cerebral
Arteries • Cerebrovascular Disorders • Dura Mater
• Female • Humans • Magnetic Resonance
Imaging • Male • Middle Aged •
Thrombophlebitis • Vasculitis • analysis* •
blood supply • diagnosis • diagnosis* •
immunology • immunology*},
Abstract = {OBJECTIVE: The purpose of this study was to determine the
frequency and types of abnormalities at arteriography in
patients with antiphospholipid antibodies (APA) and ischemic
cerebrovascular events. METHODS: Twenty-three patients with
APA and ischemic cerebrovascular events who underwent
arteriography were identified. Patients over the age of 65
years were excluded. No patients met diagnostic criteria for
systemic lupus erythematosus. All angiograms were reviewed
by two neuroradiologists. RESULTS: Seventeen patients (74%)
between the ages of 28 and 64 years (average age, 40 years)
had abnormal angiograms. Sixteen patients had arterial
abnormalities and one had dural sinus thrombosis. Ten had
solely intracranial abnormalities (nine arterial and one
venous), six had solely extracranial arterial abnormalities,
and one had both intracranial and extracranial arterial
abnormalities. Intracranial arterial abnormalities included
stem or branch occlusions of the cerebral or basilar
arteries, which were generally solitary (six patients), and
findings suggestive of vasculitis (four patients). Four
patients had stenoses of the origins of two or more great
vessels. Two patients had extracranial internal carotid
artery stenoses or occlusions that were not typical of
atheromatous disease, considered to be embolic in one
patient. In another patient, a stenosis of the origin of the
internal carotid artery was present that appeared typical of
atheromatous disease. Infarctions were seen on CT or MR
studies in 13 of 17 patients with abnormal angiograms.
CONCLUSIONS: In our group of patients, typical atheromatous
lesions at the common carotid artery bifurcation were rare.
Some lesions that are infrequent in the general stroke
population (eg, vasculitis-like findings and stenoses at the
origin of great vessels) were common. Patients with APA and
cerebrovascular events appear to differ from the general
stroke population with regard to types of arterial
abnormalities seen at arteriography.},
Language = {eng},
Key = {fds131973}
}
@article{fds132125,
Author = {JM Provenzale and GJ Joseph and DP Barboriak},
Title = {Dural sinus thrombosis: findings on CT and MR imaging and
diagnostic pitfalls.},
Journal = {AJR. American journal of roentgenology},
Volume = {170},
Number = {3},
Pages = {777-83},
Year = {1998},
Month = {March},
ISSN = {0361-803X},
Keywords = {Adult • Aged • Brain • Contrast Media •
Dura Mater • Female • Humans • Magnetic
Resonance Imaging* • Male • Middle Aged •
Sinus Thrombosis, Intracranial • Tomography, X-Ray
Computed* • blood supply • diagnosis* •
pathology • radiography},
Language = {eng},
Key = {fds132125}
}
@article{fds131987,
Author = {JM Provenzale and DP Barboriak and TL Ortel},
Title = {Dural sinus thrombosis associated with activated protein C
resistance: MR imaging findings and proband
identification.},
Journal = {AJR. American journal of roentgenology, UNITED
STATES},
Volume = {170},
Number = {2},
Pages = {499-502},
Year = {1998},
Month = {February},
ISSN = {0361-803X},
Keywords = {Adult • Dura Mater • Female • Genetic
Predisposition to Disease • Humans • Magnetic
Resonance Imaging* • Male • Protein C • Risk
Factors • Sinus Thrombosis, Intracranial • blood
• genetics* • pathology* •
physiology*},
Abstract = {OBJECTIVE: The purpose of this study was to report the
association of dural sinus thrombosis with a hypercoagulable
state associated with activated protein C resistance.
CONCLUSION: In our small study population, hemorrhagic
venous infarction was common (three of four patients) among
patients with dural sinus thrombosis and activated protein C
resistance. Four of five patients with dural sinus
thrombosis had positive tests for activated protein C
resistance. This finding, in conjunction with data from
other studies, suggests that patients with dural sinus
thrombosis may need to be studied for the presence of
activated protein C resistance. A positive finding for
activated protein C resistance can be important not only in
helping to explain the cause of thrombosis in affected
individuals but also in identifying families at risk for
thrombosis.},
Key = {fds131987}
}
@article{fds132111,
Author = {JM Provenzale and CE Spritzer and RC Nelson and TL
Ortel},
Title = {Disseminated thrombosis in primary antiphospholipid
syndrome: MR findings.},
Journal = {European journal of radiology},
Volume = {26},
Number = {3},
Pages = {244-7},
Year = {1998},
Month = {February},
ISSN = {0720-048X},
Keywords = {Adrenal Glands • Adult • Antiphospholipid Syndrome
• Humans • Infarction • Leg • Magnetic
Resonance Angiography • Magnetic Resonance Imaging
• Male • Thrombosis • blood supply •
complications* • diagnosis • diagnosis* •
etiology • etiology*},
Abstract = {We report the MR imaging findings in a patient with primary
antiphospholipid syndrome, adrenal infarction and widespread
thrombosis involving abdominal, pelvic, and pulmonary
vessels. This syndrome should be suspected in patients with
thromboses and organ infarctions of otherwise undetermined
etiology.},
Language = {eng},
Key = {fds132111}
}
@article{fds132160,
Author = {DT Ahola and JM Provenzale and DC Longee},
Title = {Metastatic rhabdomyosarcoma presenting as intracranial
hemorrhage: imaging findings.},
Journal = {European journal of radiology},
Volume = {26},
Number = {3},
Pages = {241-3},
Year = {1998},
Month = {February},
ISSN = {0720-048X},
Keywords = {Brain Neoplasms • Cerebral Hemorrhage • Child
• Humans • Magnetic Resonance Imaging • Male
• Prostatic Neoplasms • Rhabdomyosarcoma,
Embryonal • Tomography, X-Ray Computed •
complications • diagnosis • diagnosis* •
etiology* • pathology • secondary*},
Abstract = {The CNS is rarely the first site of metastasis for
rhabdomyosarcoma. CNS involvement is uncommon, and usually
seen as leptomeningeal spread after development of pulmonary
metastases. We present the imaging findings in a 13-year-old
boy in whom a large intracranial hemorrhage was the initial
presentation of surgically documented metastatic prostatic
rhabdomyosarcoma. Multiple chest CTs and radionuclide bone
scans had previously shown no evidence of pulmonary or
osseous metastases. The significance of this case in
relation to the possible role of the need for use of
chemotherapeutic agents that cross the blood-brain barriers
to prevent brain metastasis is discussed.},
Language = {eng},
Key = {fds132160}
}
@article{fds132183,
Author = {JM Provenzale and TL Ortel and NB Allen},
Title = {Systemic thrombosis in patients with antiphospholipid
antibodies: lesion distribution and imaging
findings.},
Journal = {AJR. American journal of roentgenology},
Volume = {170},
Number = {2},
Pages = {285-90},
Year = {1998},
Month = {February},
ISSN = {0361-803X},
Keywords = {Adult • Antibodies, Antiphospholipid •
Antiphospholipid Syndrome • Diagnostic Imaging •
Female • Humans • Leg • Male •
Retrospective Studies • Thrombosis • blood supply
• diagnosis* • immunology •
immunology*},
Abstract = {OBJECTIVE: The purpose of this study was to determine the
patterns of non-CNS thromboses in patients with a
hypercoagulable state associated with antiphospholipid
antibodies (APA). METHODS: A search of our institution's
clinical coagulation and immunology laboratories' records of
patients examined from January 1993 to January 1996 revealed
1290 patients with APA. Computerized records of radiologic
studies were reviewed for evidence of thrombotic events,
which were found in 93 patients (49 males and 44 females;
average age, 40 years). The anatomic distribution of
thrombotic events was recorded. RESULTS: Fifty-five patients
(59%; 29 males and 26 females; average age, 44.2 years) had
solely venous thromboses, 26 patients (28%; 15 males and 11
females; average age, 33.1 years) had solely arterial
thromboses, and 12 (13%; 5 males and 7 females; average age,
35.4 years) had both types of events. Deep vein thrombosis
(DVT) of the legs was the most common finding, occurring in
45 patients (48%). Six patients had recurrent DVT. Other
sites of venous thrombotic events included pulmonary
embolism, 30 patients (32%); thoracic veins (superior vena
cava, subclavian vein, or jugular vein), 10 patients (11%);
and abdominal or pelvic veins, 18 events in 11 patients
(12%). Sites of arterial thromboses included arteries
supplying the upper limbs (great vessels arising from the
aorta or the brachial, radial, ulnar, or digital arteries),
15 events in 12 patients (13%); aorta, one patient (1%);
abdominal or pelvic arteries, 11 events in eight patients
(9%); and arteries supplying the lower limbs (femoral or
popliteal arteries), seven patients (8%). CONCLUSIONS:
Venous thromboses were more common than arterial thromboses
in our patient group, with DVT being the most common.
However, thromboses in sites that are unusual for the
general population were also relatively common. APA should
be suspected in patients with thromboses in unusual sites or
recurrent thromboses of an otherwise unexplained
cause.},
Language = {eng},
Key = {fds132183}
}
@article{fds131944,
Title = {Provenzale JM, Barboriak DP, Ortel TL. Dural sinus
thrombosis associated with activated protein C resistance:
MR imaging findings. AJR 1998; 170:499-502},
Year = {1998},
Key = {fds131944}
}
@article{fds131945,
Title = {Gilkeson RC, Patz E, Culhane D, McAdams HP, Provenzale JM.
Thoracic manifestations of patients with antiphospholipid
antibodies. J Comput Assist Tomogr 1998;
22:241-244},
Year = {1998},
Key = {fds131945}
}
@article{fds131946,
Title = {Provenzale JM, Spritzer CE, Nelson RC, Ortel TL.
Disseminated thrombosis in primary antiphospholipid
syndrome: MR findings. European J Radiol (EJR) 1998;
26:244-247},
Year = {1998},
Key = {fds131946}
}
@article{fds131947,
Title = {Provenzale JM, Ortel TL, Allen NB. Systemic thrombosis in
patients with antiphospholipid antibodies: lesion
distribution and imaging findings. AJR 1998;
170:285-290},
Year = {1998},
Key = {fds131947}
}
@article{fds131948,
Title = {Provenzale JM, Jinkins JR. Brain and spine imaging findings
in AIDS patients. In Radiologic Clinics of North America.
Goodman P (ed). Philadelphia, W.B. Saunders
1997},
Year = {1998},
Key = {fds131948}
}
@article{fds131949,
Title = {Ahola DT, Provenzale JM, Longee DC. Metastatic
rhabdomyosarcoma presenting as intracranial hemorrhage:
imaging findings. Eur J Radiol (in press)},
Year = {1998},
Key = {fds131949}
}
@article{fds131950,
Title = {Arata MR, Provenzale JM, Vredenburgh JJ. CMV
encephalomyelitis: MR imaging finds documenting response to
ganciclovir therapy. AJR (in press)},
Year = {1998},
Key = {fds131950}
}
@article{fds131951,
Title = {Provenzale JM, Barboriak DP, Allen NB, Ortel TL. Patients
with antiphospholipid antibodies: findings at arteriography.
AJNR (in press)},
Year = {1998},
Key = {fds131951}
}
@article{fds131952,
Title = {Friedman HS, Ashley D, Kerby T, et al. Topotecan treatment
of adults with primary malignant glioma. 1997 (in
preparation)},
Year = {1998},
Key = {fds131952}
}
@article{fds131953,
Title = {Provenzale JM. Colloid Cyst. In Duke Radiology Case Review.
Provenzale JM, Nelson RC (eds). Philadelphia,
Lippincott-Raven, 1998},
Year = {1998},
Key = {fds131953}
}
@article{fds131954,
Title = {Provenzale JM. Cavernous angioma. In Duke Radiology Case
Review. Provenzale JM, Nelson RC, (eds). Philadelphia,
Lippincott-Raven, 1998},
Year = {1998},
Key = {fds131954}
}
@article{fds131955,
Title = {Provenzale JM. Germinoma. In Duke Radiology Case Review.
Provenzale JM, Nelson RC (eds). Philadelphia,
Lippincott-Raven, 1998},
Year = {1998},
Key = {fds131955}
}
@article{fds131956,
Title = {Provenzale JM. Multiple scleroisis. In Duke Radiology Case
Review. Provenzale JM, Nelson RC (eds). Philadelphia,
Lippincott-Raven, 1998},
Year = {1998},
Key = {fds131956}
}
@article{fds131957,
Title = {Provenzale JM, Nelson RC (eds). Duke Radiology Case Review.
Philadelphia, Lippincott-Raven, 1998},
Year = {1998},
Key = {fds131957}
}
@article{fds131958,
Title = {Provenzale, JM, Ortel TL, Allen NB. Non-CNS thrombosis in
patients with antiphospholipid antibodies: lesion
distribution and imaging findings. AJR 1998;
170:285-290.},
Year = {1998},
Key = {fds131958}
}
@article{fds131959,
Title = {Provenzale, JM, Joseph GJ, Barboriak DP. Pictorial essay:
dural sinus thrombosis: findings on CT and MR imaging and
diagnostic ptifalls. AJR 1998; 170:777-783.},
Year = {1998},
Key = {fds131959}
}
@article{fds131960,
Title = {Provenzale JM, Barboriak DP, Allen NB, Ortel TL.
Antiphospholipid antibodies: findings at arteriography. AJNR
1998; 19:611-616.},
Year = {1998},
Key = {fds131960}
}
@article{fds131961,
Title = {Ahola DT, Provenzale JM, Longee DC. Metastatic
rhabdomyosarcoma presenting as intracraniala hemorrhage:
imaging findings. Eur J. Radiol 1998; 26:241-243.},
Year = {1998},
Key = {fds131961}
}
@article{fds131962,
Title = {Arata MA, Provenzale JM, Vredenburgh JJ. Cytomegalovirus
encephalomyelitis: MR imaging findings documenting response
to ganciclovir therapy. AJR 1998; 171:103-105.},
Year = {1998},
Key = {fds131962}
}
@article{fds131963,
Title = {Provenzale JM, Nelso nRC, Spritzer C, Keogan M, Barboriak D,
Ortel TL. Disseminated thrombosis in primary
antiphospholipid syndrome: MR findings. Eur J Radiol
1998;26:244-247.},
Year = {1998},
Key = {fds131963}
}
@article{fds131964,
Title = {Provenzale JM, Engelter ST, Petrella JR, Smith JS, MacFall
JR. Technical innovation: use of MR exponential
diffusion-weighted images to eradicate T2 shine-through
effect. Ajr 172:537-539.},
Year = {1998},
Key = {fds131964}
}
@article{fds132066,
Title = {Provenzale JM, Ortel TL, Allen NB, Non-CNS thrombosis in
patients with antiphospholipid antibodies: lesion
distribution and imaging findings. AJR 1998;
170:285-290},
Year = {1998},
Key = {fds132066}
}
@article{fds132067,
Title = {Provenzale JM, Joseph GJ, Barboriak DP. Pictorial essay:
dural sinus thrombosis: findings on CT and MR imaging and
diagnostic pitfalls. AJR 1998; 170:777-783},
Year = {1998},
Key = {fds132067}
}
@article{fds132068,
Title = {Provenzale JM, Barboriak DP, Davey IC, Ortel TL.
Cerebrovascular disease risk factors: neuroradiologic
findings in patients with activated protein C resistance.
Radiology 1998; 207:85-89},
Year = {1998},
Key = {fds132068}
}
@article{fds132069,
Title = {Provenzale JM, Barboriak DP, Allen NB, Ortel TL.
Antiphospholipid antibodies: findings at arteriography. AJNR
1998; 19:611-616},
Year = {1998},
Key = {fds132069}
}
@article{fds132070,
Title = {Bigner DD, Brown MT, Friedman AH, Coleman RE, Akabani G,
Friedman HS, Thorstad WL, McLendon RE, Bigner SH, Zhao XG,
Pegram CN, Wikstrand CJ, Herndon II JE, Vick NA, Paleologos
N, Cokgor I, Provenzale JM, Zalutsky MR. Iodine-131-labeled
antitenascin monoclonal antibody 81C6 treatment of patients
with recurrent malignant gliomas: phase I trial results. J
Clin Oncology 1998; 16:2202-2212},
Year = {1998},
Key = {fds132070}
}
@article{fds132071,
Title = {Ahola DT, Provenzale JM, Longee DC. Metastatic
rhabdomyosarcoma presenting as intracranial hemorrhage:
imaging findings. European J Radiol (EJR) 1998;
26:241-243},
Year = {1998},
Key = {fds132071}
}
@article{fds132072,
Title = {Provenzale JM, Barboriak DP, Coleman RE. Case report. Limbic
encephalitis: comparison of F18 FDG PET and MR imaging
findings. AJR 1998; 170:1659-1660},
Year = {1998},
Key = {fds132072}
}
@article{fds132073,
Title = {Arata MA, Provenzale JM, Vredenburgh JJ. Cytomegalovirus
encephalomyelitis: MR imaging findings documenting response
to ganciclovir therapy. AJR 1998; 171:103-105},
Year = {1998},
Key = {fds132073}
}
@article{fds132074,
Title = {Provenzale JM. Diagnositc Pitfalls in MR Imaging of the
Brain. Categorial Course Syllabus, 1997 American Roentgen
Ray Society Meeting, Boston, MA, May 1997},
Year = {1998},
Key = {fds132074}
}
@article{fds132075,
Title = {Bennett G, Provenzale JM. Schistosomal myelitis: Findings at
MR imaging. Eur J Radiol (in press)},
Year = {1998},
Key = {fds132075}
}
@article{fds132076,
Title = {Provenzale JM, Spritzer CE, Nelson RC, Ortel TL.
Disseminated thrombosis in primary antiphospholipid
syndrome: MR findings. Eur J Radiol (in press)},
Year = {1998},
Key = {fds132076}
}
@article{fds132077,
Title = {Provenzale JM, Ortel TL, Allen NB. Non-CNS thrombosis in
patients with antiphospholipid antibodies: lesion
distribution and imaging findings. AJR (in
press)},
Year = {1998},
Key = {fds132077}
}
@article{fds132078,
Title = {Provenzale JM, Barboriak DP, Ortel TL. Dural sinus
thrombosis associated with activated protein C resistance:
MR imaging findings. AJR (in press)},
Year = {1998},
Key = {fds132078}
}
@article{fds132079,
Title = {Provenzale JM, Barboriak DP, Coleman RE. Case Report. Limbic
encephalitis: comparison of F18 FDG PET and MR imaging
findings. AJR (in press)},
Year = {1998},
Key = {fds132079}
}
@article{fds132080,
Title = {Gilkeson RC, Patz E, Culhane DK, McAdams HP, Provenzale JM.
Thoracic manifestations of patients with antiphospholipid
antibodies. J Comput Assist Tomogr (in press)},
Year = {1998},
Key = {fds132080}
}
@article{fds132081,
Title = {Friedman HS, Ashley DM, Longee DC, et al. Treatment of
adults with progressive oligodendroglioma with carboplatin
(CBDCA). 1997 (submitted)},
Year = {1998},
Key = {fds132081}
}
@article{fds132082,
Title = {Ahearn E, Stephens D, Provenzale JM, et al. familial
leucoencephalopathy in bipolar disorders. Am J Psychiatry
1998; 155:1605-1607},
Year = {1998},
Key = {fds132082}
}
@article{fds132083,
Title = {Provenzale JM. Diagnostic Pitfalls in MR Imaging of the
Brain. Categorical Course Syllabus, 1997 American Roentgen
Ray Society Meeting, Boston, MA, May 1997},
Year = {1998},
Key = {fds132083}
}
@article{fds132084,
Title = {Provenzale JM, Jinkins JR. Brain and spine imaging findings
in AIDS patients. In Radiologic Clinics of North America.
Goodman P (ed). Philadelphia, W.B. Saunders
1997},
Year = {1998},
Key = {fds132084}
}
@article{fds132085,
Title = {Provenzale JM. Spinal epidural hemotoma. In Duke Radiology
Case Review. Provenzale JM, Nelson RC (eds). Philadelphia,
Lippincott-Raven, 1998},
Year = {1998},
Key = {fds132085}
}
@article{fds132086,
Title = {Provenzale JM. Carotid dissection. In Duke Radiology Case
Review. Provenzale JM, Nelson RC, (eds). Philadelphia,
Lippincott-Raven, 1998},
Year = {1998},
Key = {fds132086}
}
@article{fds132087,
Title = {Provenzale JM. Agenesis of the corpus callosum. In Duke
Radiology Case Review. Provenzale JM, Nelson RC (eds).
Philadelphia, Lippincott-Raven, 1998},
Year = {1998},
Key = {fds132087}
}
@article{fds132088,
Title = {Provenzale JM. Epidermoid tumor. In Duke Radiology Case
Review. Provenzale JM, Nelson RC (eds). Philadelphia,
Lippincott-Raven, 1998},
Year = {1998},
Key = {fds132088}
}
@article{fds132089,
Title = {Provenzale, JM, Barboriak DP, Ortel TL. Dural sinus
thrombosis associated with activated protein C resistance:
MR imaging findings. AJR 1998; 170:499-502.},
Year = {1998},
Key = {fds132089}
}
@article{fds132090,
Title = {Provenzale, JM Barboriak DP, Davey IC, Ortel TL.
cerebrovascular disease risk factors: neuroradiologic
findings in patients with activated protein C resistance.
Radiology 1998; 207:85-89.},
Year = {1998},
Key = {fds132090}
}
@article{fds132091,
Title = {Gilkeson RC, Patz E, Culhane D, McAdams HP, Provenzale JM.
Thoracic manifestations of patient with antiphospholipid
antibodies. J comput Assist Tomogr 1998;
22:241-244.},
Year = {1998},
Key = {fds132091}
}
@article{fds132092,
Title = {Bigner DD, Brown MT, Friedman AH, Coleman RE, Akabani G,
Friedman HS, Thorstad WL, McLendon RE, Bigner SH, Zhao X-G,
Pegram CN, Wikstrand CJ, Herndon II JE, Vick NA , Paleologos
N, Cokgor I Provenzale JM, Zalutsky MR. Iodine-131-labeled
antitenascin monoclonal antibody 81C6 treatment of patients
with recurrent malignant gliomas: phase I trial results. J
Clin Oncology 1998; 16:2202-2212.},
Year = {1998},
Key = {fds132092}
}
@article{fds132093,
Title = {Provenzale, JM, Spritzer CE, Nelson RC, Ortel TL.
Disseminated thrombosis in primary antiphospholipid
syndrome: MR findings. Eur J Radiol 1998;
26:244-247.},
Year = {1998},
Key = {fds132093}
}
@article{fds132094,
Title = {Provenzale JM, Barboriak DP, Coleman RE. Case report. Limbic
encephalitis: comparison of 18F FDG PET and MR imaging
findings. AJR 1998; 170:1659-1660.},
Year = {1998},
Key = {fds132094}
}
@article{fds132095,
Title = {Provenzale JM, Ortel TL, Allen NB. Systemic thrombosis in
patients with antiphospholipid antibodies: lesion
distribution and imaging findings. AJR 1998:
170:285-290.},
Year = {1998},
Key = {fds132095}
}
@article{fds132096,
Title = {Bennett G, Provenzale JM. Schistosomal myelitis: Findings at
MR imaging. Eur J Radiol 1998;27:268-270.},
Year = {1998},
Key = {fds132096}
}
@article{fds132097,
Title = {Provenzale JM, Frush DP, Ortel TL. Recurrent thrombosis of
the superior vena cava associated with activated protein C
resistance: imaging findings. Pediatr Radiol 1998;
28:597-598.},
Year = {1998},
Key = {fds132097}
}
@article{fds132098,
Title = {Barboriak DP, Provenzale JM. MR arteriography of
intracranial circulation. AJR 1998;171: 1469-1478.},
Year = {1998},
Key = {fds132098}
}
@article{fds132099,
Title = {Ahearn E. Stephens DC, Cassidy F, Van Meter SA, Provenzale
JM, Seldin MF, Weisler RH, Krishnan KRR. Familial
leucoencephalopathy in bipolar disorders. Am J Psychiatry
1998;155:1605-1607.},
Year = {1998},
Key = {fds132099}
}
@article{fds132100,
Title = {Ijdo JW, Conti-Kelly AM, Greco P, Abedi M, Amos M,
Provenzale JM, Greco TPP. Antiphospholipid antibodies in
patients with multiple sclerosis and MS-like illnesses: MS
or APS? Lupus 1998;7:1-7.},
Year = {1998},
Key = {fds132100}
}
@article{fds132101,
Title = {Friedman HS, McLendon RE, Kerby TA, Dugan M, Bigner SH,
Henry AJ, Ashley DM, Krischer J, Lovell S, Rasheed K,
Marchev F, Seman AJ, Cokgor I, Rich J, Stewart E, Colvin OM,
Provenzale JM, Bigner DD, Hagalund MM, Friedman AH, Modrich
PL. DNA mismatch repair 06-Alkylguanine-DNA alkyltransferase
analysis and response to temodal in newly diagnosed
malignant glioma. J Clin Oncol 1998;16:3851-3857.},
Year = {1998},
Key = {fds132101}
}
@article{fds132179,
Author = {BS Hertzberg and MA Kliewer and JM Provenzale},
Title = {Cyst of the velum interpositum: antenatal ultrasonographic
features and differential diagnosis.},
Journal = {Journal of ultrasound in medicine : official journal of the
American Institute of Ultrasound in Medicine},
Volume = {16},
Number = {11},
Pages = {767-70},
Year = {1997},
Month = {November},
ISSN = {0278-4297},
Keywords = {Adult • Brain Diseases • Cysts • Diagnosis,
Differential • Female • Fetal Diseases •
Humans • Infant, Newborn • Magnetic Resonance
Imaging • Pregnancy • Tomography, X-Ray Computed
• Ultrasonography, Prenatal* • diagnosis •
ultrasonography*},
Language = {eng},
Key = {fds132179}
}
@article{fds132127,
Author = {JM Provenzale and DP Barboriak},
Title = {Brain infarction in young adults: etiology and imaging
findings.},
Journal = {AJR. American journal of roentgenology, UNITED
STATES},
Volume = {169},
Number = {4},
Pages = {1161-8},
Year = {1997},
Month = {October},
ISSN = {0361-803X},
Keywords = {Adult • Brain • Cerebral Angiography •
Cerebral Infarction • Humans • Magnetic Resonance
Imaging • Tomography, X-Ray Computed • diagnosis*
• etiology • pathology • radiography},
Abstract = {The causes of stroke in young adults differ substantially
from those in older adults. In many instances, the diagnosis
can be made by taking a clinical history and performing
laboratory studies (e.g., in patients who have multiple
thromboses associated with anti-phospholipid antibodies). In
other circumstances, clues to the diagnosis can be found on
routine CT and MR studies. However, in many circumstances,
imaging tailored to a specific diagnosis is important (e.g.,
MR imaging of the neck in patients with suspected arterial
dissection). In yet other cases, additional studies (e.g.,
echocardiography in suspected cardiogenic embolism) are
important to establish the cause.},
Key = {fds132127}
}
@article{fds132124,
Author = {JM Provenzale, JR Jinkins},
Title = {Brain and spine imaging findings in AIDS
patients.},
Journal = {Radiologic clinics of North America, UNITED
STATES},
Volume = {35},
Number = {5},
Pages = {1127-66},
Year = {1997},
Month = {September},
ISSN = {0033-8389},
Keywords = {AIDS Dementia Complex • AIDS-Related Opportunistic
Infections • Brain Diseases • Brain Neoplasms
• Cryptococcosis • Diagnostic Imaging* •
Encephalitis • Humans • Lymphoma, AIDS-Related
• Spinal Cord Diseases • Spinal Cord Neoplasms
• Toxoplasmosis, Cerebral • Tuberculosis •
Virus Diseases • diagnosis • diagnosis* •
virology},
Abstract = {Central nervous system complications in AIDS patients are
common and often the cause of severe morbidity and
mortality. Most symptomatic central nervous system
complications in AIDS patients involve the brain,
principally in the form of HIV encephalitis, various other
forms of infection, or development of neoplasms. The imaging
findings are important to recognize because in many
instances the underlying brain lesions are responsive to
medical therapy.},
Key = {fds132124}
}
@article{fds132129,
Author = {DF Kallmes and JM Provenzale and HJ Cloft and RE McClendon},
Title = {Typical and atypical MR imaging features of intracranial
epidermoid tumors.},
Journal = {AJR. American journal of roentgenology},
Volume = {169},
Number = {3},
Pages = {883-7},
Year = {1997},
Month = {September},
ISSN = {0361-803X},
Keywords = {Adult • Brain • Brain Diseases • Epidermal
Cyst • Female • Humans • Magnetic Resonance
Imaging* • Male • diagnosis* •
pathology*},
Abstract = {OBJECTIVE: We categorized the MR imaging characteristics of
intracranial epidermoid tumors. METHODS: MR images from 23
cases of intracranial epidermoid tumors were reviewed
retrospectively. Signal intensities of tumor relative to
surrounding structures were noted, as were the internal
architecture of the tumors and the presence and degree of
hydrocephalus. RESULTS: Seventeen (74%) of 23 cases of
intracranial epidermoid tumors were revealed as slightly
hyperintense relative to CSF on T1-weighted MR images.
Nineteen (95%) of 20 cases were hyperintense relative to CSF
on proton density-weighted MR images. Fifteen (65%) of 23
cases were isointense to CSF on T2-weighted MR images,
whereas the remaining eight cases (35%) were hyperintense to
CSF on T2-weighted MR images. One (4%) of 23 cases showed
signal intensity that was isointense to CSF on all pulse
sequences. Fifteen (65%) of 23 cases showed heterogeneous
signal characteristics on either T1-weighted or proton
density-weighted MR images, or both. Eight (35%) of 23 cases
showed a rim of hyperintensity on proton density-weighted MR
images. Five (33%) of the 15 cases that received gadolinium
showed rim enhancement. Five (22%) of 23 cases were
multilocular, with different regions of tumors showing
highly variable imaging characteristics. Two (9%) of 23
cases showed high signal intensity on T2-weighted MR images
in the adjacent brain parenchyma. Two (9%) of 23 cases
showed mild hydrocephalus. Six (43%) of 14 tumors that
either originated in or secondarily involved the
cerebellopontine angle also extended into the ipsilateral
Meckel's cave. CONCLUSIONS: On T1-, proton density-, and
T2-weighted MR images intracranial epidermoid tumors usually
showed heterogeneous signal intensity that was hyperintense
to CSF. On all spin-echo pulse sequences epidermoid tumors
with signal characteristics isointense to CSF were unusual.
Hydrocephalus, even in the setting of marked displacement
and compression of the brainstem, was not usually seen on MR
imaging. Meckel's cave was often involved secondarily with
epidermoid tumors that involved the cerebellopontine
angle.},
Language = {eng},
Key = {fds132129}
}
@article{fds132155,
Author = {DP Barboriak and JM Provenzale},
Title = {Pictorial review: magnetic resonance angiography of arterial
variants at the Circle of Willis.},
Journal = {Clinical radiology},
Volume = {52},
Number = {6},
Pages = {429-36},
Year = {1997},
Month = {June},
ISSN = {0009-9260},
Keywords = {Adolescent • Adult • Cerebral Arteries •
Circle of Willis • Diagnosis, Differential •
Female • Humans • Intracranial Aneurysm •
Magnetic Resonance Angiography* • Male • Middle
Aged • abnormalities • abnormalities* •
pathology},
Abstract = {As intracranial MR angiography becomes more widely used and
spatial resolution improves, anomalies at the Circle of
Willis which have been previously well described on
angiographic studies and anatomic dissections will become
more frequently appreciated by MR angiography. Recognition
of these variants is important to avoid confusion of the
anomalies with aneurysms, evaluate collateral pathways in
the intracerebral circulation, and enhance pre-operative
planning in patients undergoing surgery at the skull base.
In this review, we illustrate several of the more common
types of anomalies at the Circle of Willis and discuss the
possible clinical significance of each.},
Language = {eng},
Key = {fds132155}
}
@article{fds132133,
Author = {JM Provenzale and P Schaefer and ST Traweek and J Ferry and JO Moore and AH
Friedman, RE McLendon},
Title = {Craniocerebral plasmacytoma: MR features.},
Journal = {AJNR. American journal of neuroradiology},
Volume = {18},
Number = {2},
Pages = {389-92},
Year = {1997},
Month = {February},
ISSN = {0195-6108},
Keywords = {Adult • Aged • Brain Neoplasms • Diagnosis,
Differential • Female • Humans • Magnetic
Resonance Imaging* • Meningeal Neoplasms •
Meningioma • Plasmacytoma • Skull Neoplasms •
diagnosis • diagnosis*},
Abstract = {We report the MR imaging findings in two patients with
solitary craniocerebral plasmacytoma, a benign plasma cell
tumor that can arise from the skull, the dura, or, rarely,
the brain. In both patients, the lesion was extraaxial and
nearly isointense with gray matter on T2-weighted MR images,
and diffusely enhanced after administration of contrast
material, bearing some similarities to meningioma. A
diagnosis of solitary craniocerebral plasmacytoma should be
considered when a mass with these imaging features is seen,
because total excision may not be necessary for this
radiosensitive tumor.},
Language = {eng},
Key = {fds132133}
}
@article{fds131930,
Title = {Provenzale JM, Allen NB. Wegener granulomatosis: CT and MR
findings AJNR 1996; 17:785-792.},
Year = {1997},
Key = {fds131930}
}
@article{fds131931,
Title = {Provenzale JM, Barboriak D, Allen NB, Ortel TL. Patients
with antiphospholipid antibodies: CT and MR findings of the
brain. AJR 1996; 167:1573-1578.},
Year = {1997},
Key = {fds131931}
}
@article{fds131932,
Title = {Barboriak DP, Provenzale JM. Pictorial review: magnetic
resonance angiography of arterial variants at the Circle of
Willis. Clinical Radiology 1997; 52:429-436.},
Year = {1997},
Key = {fds131932}
}
@article{fds131933,
Title = {Hertzberg BS, Kliewer MA, Provenzale JM. Cyst of the velum
interpositum: antenatal ultrasound features and differential
diagnosis. J Ultrasound Med 1997; 16:767-770.},
Year = {1997},
Key = {fds131933}
}
@article{fds131934,
Title = {Bennett, G. Provenzale JM. Schistosomal myelitis: Findings
at MR imaging. Eur J Radiol (in press).},
Year = {1997},
Key = {fds131934}
}
@article{fds131935,
Title = {Ahola DT, Provenzale JM, Longee DC. Metastatic
rhabdomyosarcoma presenting as intracranial hemorrhage:
Imaging Finding. Eur J Radiol (in press).},
Year = {1997},
Key = {fds131935}
}
@article{fds131936,
Title = {Arata MA, Provenzale JM, Vredenburgh JJ. CMV
encephalomyelitis: MR imaging findings documenting response
to ganciclovir therapy. AJR (in press).},
Year = {1997},
Key = {fds131936}
}
@article{fds131937,
Title = {Provenzale JM, Barboriak DP, Allen NB, Ortel TL. Patients
with antiphospholipid antibodies: findings at arteriography.
AJNR (in press).},
Year = {1997},
Key = {fds131937}
}
@article{fds131938,
Title = {Friedman HS, Ashley D, Kerby T, et al. Topotecan treatment
of adults with primary malignant glioma. 1997. (in
preparation).},
Year = {1997},
Key = {fds131938}
}
@article{fds131939,
Title = {Provenzale JM, Jinkins JR. Brain and spine imaging findings
in AIDS patients. In Radiologic Clinics of North America.
Goodman P (ed). Philadelphia, W.B. Saunders
1997.},
Year = {1997},
Key = {fds131939}
}
@article{fds131940,
Title = {Provenzale JM. Cavernous angioma. In Duke Radiology Case
Review. Provenzale JM, Nelson RC (eds). Philadelphia,
Lippincott-Raven, 1998.},
Year = {1997},
Key = {fds131940}
}
@article{fds131941,
Title = {Provenzale JM. Germinoma. In Duke Radiology Case Review.
Provenzale JM, Nelson RC (eds). Philadelphia,
Lippincott-Raven, 1998.},
Year = {1997},
Key = {fds131941}
}
@article{fds131942,
Title = {Provenzale JM. Multiple sclerosis. In Duke Radiology Case
Review. Provenzale JM, Nelson RC (eds). Philadelphia,
Lippencott-Raven, 1998.},
Year = {1997},
Key = {fds131942}
}
@article{fds131943,
Title = {Provenzale, JM, Nelson RC (eds). Duke Radiology Case Review.
Philadelphia, Lippincott-Raven, 1998.},
Year = {1997},
Key = {fds131943}
}
@article{fds132044,
Title = {Provenzale JM, Gorecki JP, Koen JL. Cerebral aneurysms
associated with seizures but without clinical signs of
rupture: seemingly distinctive MR imaging findings in two
patients. AJR 1996; 167:230-232.},
Year = {1997},
Key = {fds132044}
}
@article{fds132045,
Title = {Provenzale JM, Grahm ML. Reversible leukoencephalopathy
associated with graft-vs-host disease: MR finding. AJNR
1996; 17:1290-1294.},
Year = {1997},
Key = {fds132045}
}
@article{fds132046,
Title = {Provenzale JM, Schaefer P, Traweek ST, Ferry J, Moore JO,
Friedman AH, McLendon RE. Craniocerebral Plasmacytoma - MR
features. AJNR 1997; 18:389-392.},
Year = {1997},
Key = {fds132046}
}
@article{fds132047,
Title = {Provenzale JM, Barboriak DP. Brain infarction in young
adults: Etiology and imaging findings. AJR 1997;
169:1161.},
Year = {1997},
Key = {fds132047}
}
@article{fds132048,
Title = {Kallmes DF, Provenzale JM, Cloft HJ, McClendon RE. Typical
and atypical MR imaging features of intracranial epidermoid
tumors. AJR 1997; 169:883-887.},
Year = {1997},
Key = {fds132048}
}
@article{fds132049,
Title = {Provenzale JM. Nontraumatic neuroradiologic emergencies.
Emergency Radiology 1997;4:236-248.},
Year = {1997},
Key = {fds132049}
}
@article{fds132050,
Title = {Madden DJ, Tukington TG, Provenzale JM, Hawk TC, Hoffman JM,
Coleman RE. Selective and divided visual attention:
age-related changes in regional cerebral blood flow measured
by H2150 PET. Human Brain Mapping 1997; 5:389-409.},
Year = {1997},
Key = {fds132050}
}
@article{fds132051,
Title = {Provenzale JM. Diagnostic Pitfalls in MR Imaging of the
Brain. Categorical Course Syllabus, 1997 American Roentgen
Ray Society meeting, Boston, MA, May 1997.},
Year = {1997},
Key = {fds132051}
}
@article{fds132052,
Title = {Provenzale JM, Jinkins JR. Brain and spine imaging findings
in AIDS patients. In Radiologic Clinics of North America.
Goodman P (ed). Philadelphia, W.B. Saunders
1997.},
Year = {1997},
Key = {fds132052}
}
@article{fds132053,
Title = {Provenzale JM, Spritzer CE, Nelson RC, Ortel TL.
Disseminated thrombosis in primary antiphospholipid syndrom:
MR findings. Eur J Radiol (in press).},
Year = {1997},
Key = {fds132053}
}
@article{fds132054,
Title = {Provenzale JM, Ortel TL, Allen NB. Non-CNS thrombosis jin
patients with antiphospholipid antibodies: lesion
distribution and imaging finding. AJR (in
press).},
Year = {1997},
Key = {fds132054}
}
@article{fds132055,
Title = {Provenzale JM, Barboriak DP, Ortel TL. Dural sinus
thrombosis associated with activated protein C resistance:
MR imaging findings. AJR (in press).},
Year = {1997},
Key = {fds132055}
}
@article{fds132056,
Title = {Provenzale JM, Barboriak DP, Coleman RE. Case Report. Limbic
encephalitis: comparison of F18 FDG PET and MR imaging
findings. AJR (in press).},
Year = {1997},
Key = {fds132056}
}
@article{fds132057,
Title = {Gilkeson RC, Patz E, Culhane DK, McAdams HP, Provenzale JM.
Thoracic manifestations of patients with antiphospholipid
antibodies. J Comput Assist Tomogr (in press).},
Year = {1997},
Key = {fds132057}
}
@article{fds132058,
Title = {Friedman HS, Ashley DM, Longee DC, et al. Treatment of
adults with progressive oligodendroglioma with carboplatin
(CBDCA). 1997 (submitted).},
Year = {1997},
Key = {fds132058}
}
@article{fds132059,
Title = {Ahearn E, Stephens D, Provenzale JM, et al. Familial
leucoencephalopathy in bipolar disorders. 1997.
(submitted).},
Year = {1997},
Key = {fds132059}
}
@article{fds132060,
Title = {Provenzale JM. Diagnostic Pitfalls in MR Imaging of the
Brain. Categorical Course Syllabus, 1997 American Roentgen
Ray Society meeting. Boston, MA, May 1997.},
Year = {1997},
Key = {fds132060}
}
@article{fds132061,
Title = {Provenzale JM. Colloid cyst. In Duke Radiology Case Review.
Provenzale JM, Nelson RC (eds). Philadelphia,
Lippincott-Raven, 1998.},
Year = {1997},
Key = {fds132061}
}
@article{fds132062,
Title = {Provenzale JM. Spinal epidural hematoma. In Duke Radiology
Case Review. Provenzale JM, Nelson RC (eds). Philadelphia,
Lippincott-Raven, 1998.},
Year = {1997},
Key = {fds132062}
}
@article{fds132063,
Title = {Provenzale JM. Carotid dissection. In Duke Radiology Case
Review. Provenzale JM, Nelson RC (eds). Philadelphia,
Lippincott-Raven, 1998.},
Year = {1997},
Key = {fds132063}
}
@article{fds132064,
Title = {Provenzale JM. Agenesis of the corpus callosum. In Duke
Radiology Case Review. Provenzale JM, Nelson RC (eds).
Philadelphia, Lippincott-Raven, 1998.},
Year = {1997},
Key = {fds132064}
}
@article{fds132065,
Title = {Provenzale JM. Epidermoid tumor. In Duke Radiology Case
Review. Provenzale JM, Nelson RC (eds). Philadelphia,
Lippincott-Raven, 1998.},
Year = {1997},
Key = {fds132065}
}
@article{fds192780,
Author = {DJ Madden and TG Turkington and JM Provenzale and TC Hawk and JM
Hoffman, RE Coleman},
Title = {Selective and divided visual attention: age-related changes
in regional cerebral blood flow measured by H2(15)O
PET.},
Journal = {Human brain mapping},
Volume = {5},
Number = {6},
Pages = {389-409},
Year = {1997},
ISSN = {1065-9471},
url = {http://dx.doi.org/10.1002/(SICI)1097-0193(1997)5:6<389::AID-HBM1>3.0.CO;2-#},
Abstract = {Regional cerebral blood flow (rCBF) was measured using
H2(15)O and positron emission tomography (PET) to test the
hypothesis that age-related changes in the pattern of rCBF
activation would be greater under divided attention
conditions than under selective attention conditions.
Subjects were 24 right-handed men: 12 young adults (age
21-28 years), and 12 older adults (age 60-77 years).
Measurement of rCBF was obtained during performance of three
visual search task conditions, each of which involved
viewing a series of nine-letter displays and making a
two-choice button press response to each display. Analyses
of subjects' mean reaction time and error rate confirmed
that older adults' search performance was disproportionately
impaired when it was necessary to divide attention among the
display positions. The rCBF data indicated that attending
selectively to a target letter in a known (central) location
was not associated with cortical activation for either age
group. The requirement to divide attention among the display
positions led to rCBF activation in occipitotemporal,
occipitoparietal, and prefrontal cortical regions. In the
divided-attention condition, rCBF activation in the
occipitotemporal pathway was relatively greater for young
adults; activation in prefrontal regions was relatively
greater for older adults. These differences in rCBF
activation were related to search reaction time and suggest
that, when attention was divided, young adults' performance
relied primarily on letter identification processes, whereas
older adults required the recruitment of additional forms of
task control.},
Language = {eng},
Doi = {10.1002/(SICI)1097-0193(1997)5:6<389::AID-HBM1>3.0.CO;2-#},
Key = {fds192780}
}
@article{fds131998,
Author = {JM Provenzale and NB Allen},
Title = {Neuroradiologic findings in polyarteritis
nodosa.},
Journal = {AJNR. American journal of neuroradiology},
Volume = {17},
Number = {6},
Pages = {1119-26},
Year = {1996},
Month = {December},
ISSN = {0195-6108},
Keywords = {Adult • Brain • Cerebral Angiography* •
Cerebral Infarction • Diagnosis, Differential •
Female • Humans • Intracranial Embolism and
Thrombosis • Magnetic Resonance Imaging* • Male
• Middle Aged • Polyarteritis Nodosa •
Sensitivity and Specificity • Tomography, X-Ray
Computed* • blood supply • diagnosis •
diagnosis* • pathology},
Abstract = {OBJECTIVE: To demonstrate the neuroradiologic findings in
patients with polyarteritis nodosa. METHODS: A review of
hospital records for a 10-year period revealed 50 patients
with a discharge diagnosis of polyarteritis nodosa. Thirteen
patients had undergone neuroimaging, and abnormal findings
were found in 5 cases; these were the subjects of this
study. RESULTS: All 5 patients had abnormal findings on CT
scans, 3 had abnormal findings on MR images, and 1 had an
abnormal finding on a cerebral angiogram. All patients had
cerebral cortical or subcortical infarctions, and 1 also had
small infarctions within the brain stem and cerebellum. One
patient had cerebral angiographic findings of arteritis. The
diagnosis of arteritis was considered probable or possible
in 3 other patients. Three patients had echocardiographic
evidence of concentric hypertrophy and a hypocontractile
left ventricle resulting from polyarteritis nodosa-related
hypertension. Cardiogenic embolism was considered the likely
cause in 1 patient. CONCLUSIONS: Small peripheral cerebral
infarctions, consistent with an arteritis involving
medium-sized and small arteries, were the most common
finding. However, cardiogenic embolism should also be
considered as a possible cause of cerebral infarction in
patients with polyarteritis nodosa who have left ventricular
dysfunction.},
Language = {eng},
Key = {fds131998}
}
@article{fds131975,
Author = {JM Provenzale and DP Barboriak and NB Allen and TL
Ortel},
Title = {Patients with antiphospholipid antibodies: CT and MR
findings of the brain.},
Journal = {AJR. American journal of roentgenology, UNITED
STATES},
Volume = {167},
Number = {6},
Pages = {1573-8},
Year = {1996},
Month = {December},
ISSN = {0361-803X},
Keywords = {Adult • Antibodies, Antiphospholipid • Brain
• Cerebral Infarction • Child • Female •
Humans • Lupus Erythematosus, Systemic • Magnetic
Resonance Imaging* • Male • Middle Aged •
Sinus Thrombosis, Intracranial • Tomography, X-Ray
Computed* • analysis* • diagnosis •
immunology • pathology • pathology* •
radiography • radiography*},
Abstract = {OBJECTIVE: The purpose of this study was to determine the
spectrum of neuroradiologic findings in patients with
antiphospholipid antibodies (APA) and to compare findings in
systemic lupus erythematosus (SLE) and non-SLE patients.
MATERIALS AND METHODS: We identified 110 patients with APA
who underwent CT or MR imaging, of whom 59 (54%) had
abnormal studies. Of these 59 patients, abnormalities were
categorized as large infarcts, cortical infarcts, lacunar
infarcts, hyperintense white matter foci on T2-weighted
images, or dural sinus thrombosis. White matter foci were
designated as small (< 5mm) or large (> 5 mm). RESULTS:
Large infarcts were the most common abnormality, seen in 24
of 110 (22%) patients, followed in frequency by hyperintense
white matter foci, seen in 19 of 110 (17%) patients.
Ninety-five percent of patients with hyperintense white
matter foci had at least one large lesion, and 76% had five
or more small foci, three or more large foci, or both. Small
cortical infarcts and lacunar infarcts were seen in 11 of
110 (10%) and 10 of 110 (9%) patients, respectively. Dural
sinus thrombosis was seen in five patients. The frequency of
abnormalities was high in both the SLE (57%) and the non-SLE
(41%) groups. Large infarcts were more common in the non-SLE
group (26%) than in the SLE group (5%). Although
hyperintense white matter foci and cortical infarcts were
more common in SLE patients, the differences were not
statistically significant. CONCLUSION: Infarcts of various
sizes and hyperintense white matter foci are the most common
abnormalities seen on CT and MR imaging in patients with
APA. We found no significant differences in frequencies of
abnormalities seen between non-SLE and SLE
patients.},
Key = {fds131975}
}
@article{fds132151,
Author = {JM Provenzale and ML Graham},
Title = {Reversible leukoencephalopathy associated with
graft-versus-host disease: MR findings.},
Journal = {AJNR. American journal of neuroradiology, UNITED
STATES},
Volume = {17},
Number = {7},
Pages = {1290-4},
Year = {1996},
Month = {August},
ISSN = {0195-6108},
Keywords = {Adrenal Cortex Hormones • Bone Marrow Transplantation
• Brain • Brain Stem • Child •
Dose-Response Relationship, Drug • Female • Graft
vs Host Disease • Humans • Leukoencephalopathy,
Progressive Multifocal • Magnetic Resonance Imaging*
• Postoperative Complications • complications*
• diagnosis* • drug therapy • etiology*
• pathology • therapeutic use},
Abstract = {Ten weeks after undergoing bone marrow transplantation for
metastatic lymphoma of the parotid gland, a 9-year-old girl
became disoriented and had tremor and myoclonus in the
context of graft-versus-host disease (GVHD). MR images
showed abnormal signal primarily within the brain stem and
deep white matter, which resolved almost completely after
treatment. The findings are consistent with brain
involvement by GVHD.},
Key = {fds132151}
}
@article{fds131983,
Author = {JM Provenzale and JP Gorecki and JL Koen},
Title = {Cerebral aneurysms associated with seizures but without
clinical signs of rupture: seemingly distinctive MR imaging
findings in two patients.},
Journal = {AJR. American journal of roentgenology, UNITED
STATES},
Volume = {167},
Number = {1},
Pages = {230-2},
Year = {1996},
Month = {July},
ISSN = {0361-803X},
Keywords = {Adult • Aged • Aneurysm, Ruptured • Humans
• Intracranial Aneurysm • Magnetic Resonance
Imaging* • Male • Seizures • complications
• diagnosis* • etiology*},
Key = {fds131983}
}
@article{fds131978,
Author = {JM Provenzale and JC Morgenlander and D Gress},
Title = {Spontaneous vertebral dissection: clinical, conventional
angiographic, CT, and MR findings.},
Journal = {Journal of computer assisted tomography},
Volume = {20},
Number = {2},
Pages = {185-93},
Year = {1996},
Month = {May},
ISSN = {0363-8715},
Keywords = {Adult • Aneurysm, Dissecting • Carotid Artery
Diseases • Carotid Artery, Internal • Cerebral
Angiography* • False Negative Reactions • Female
• Fibromuscular Dysplasia • Humans •
Hypertension • Magnetic Resonance Imaging* • Male
• Middle Aged • Retrospective Studies •
Subarachnoid Hemorrhage • Terminology as Topic •
Tomography, X-Ray Computed* • Treatment Outcome •
Vertebral Artery* • complications • diagnosis*
• drug therapy • radiography},
Abstract = {OBJECTIVE: The purpose of this study was to determine if
typical clinical and neuroradiologic patterns exist in
patients with spontaneous vertebral artery (VA) dissection.
METHODS: The medical records and neuroradiologic
examinations of 14 patients with spontaneous VA dissection
were reviewed. The medical records were examined to exclude
patients with a history of trauma and to record evidence of
a nontraumatic precipitating event ("trivial trauma") and
presence of possible risk factors such as hypertension. All
patients underwent conventional angiography, 13 either CT or
MRI (11 both CT and MRI), and 3 MRA. Conventional
arteriograms were evaluated for dissection site, evidence of
fibromuscular dysplasia, luminal stenosis or occlusion, and
pseudoaneurysm formation. CT examinations for the presence
of infarction or subarachnoid hemorrhage. MR examinations
for the presence of infarction or arterial signal
abnormality, and MR angiograms for abnormality of the
arterial signal column. RESULTS: Seven patients had
precipitating events within 24 h of onset of symptoms that
may have been causative of dissection and five had
hypertension. At catheter angiography, two patients had
dissections in two arteries (both VAs in one patient, VA and
internal carotid artery in one patient), giving a total of
15 VAs with dissection. Dissection sites included V1 in four
patients, V2 in one patient, V3 in three patients, V4 in six
patients, and both V3 and V4 in one patient. Luminal
stenosis was present in 13 VAs, occlusion in 2,
pseudoaneurysm in 1, and evidence of fibromuscular dysplasia
in 1. Posterior circulation infarcts were found on CT or MR
in five patients. Subarachnoid hemorrhage was found on CT in
two patients and by lumbar puncture alone in two patients.
Abnormal periarterial signal on MRI was seen in three
patients. MRA demonstrated absent VA signal in one patient,
pseudoaneurysm in one, and a false-negative examination in
one. Repeat catheter angiography of nine VAs at an interval
ranging from 2 weeks to 1 year showed progression to
occlusion in two arteries, unchanged appearance in 4, and
angiographic resolution in three, which did not closely
correlate with clinical outcome. CONCLUSIONS: No preferred
site of dissection along the course of the VA was found in
this study. CT and MR examinations of the head are
frequently normal in patients with VA dissections. No
correlation between clinical outcome and findings at repeat
angiography was demonstrated.},
Language = {eng},
Key = {fds131978}
}
@article{fds131966,
Author = {JM Provenzale and JP Glass},
Title = {MRI in hemiballismus due to subthalamic nucleus hemorrhage:
an unusual complication of liver transplantation.},
Journal = {Neuroradiology},
Volume = {38 Suppl 1},
Pages = {S75-7},
Year = {1996},
Month = {May},
ISSN = {0028-3940},
Keywords = {Cerebral Hemorrhage • Humans • Liver
Transplantation • Magnetic Resonance Imaging* •
Male • Middle Aged • Movement Disorders •
Thalamic Nuclei • adverse effects* • diagnosis*
• etiology • etiology* • pathology*},
Abstract = {A 60-year-old man developed hemiballismus due to an
intracranial hemorrhage involving the subthalamic nucleus 8
weeks after orthotopic liver transplantation. The hemorrhage
was thought to be due to alterations in cerebral blood flow
following a period of hypotensive shock due to sepsis, in
the presence of anticoagulant therapy and thrombocytopenia.
This represents a rare neurologic complication of liver
transplantation.},
Language = {eng},
Key = {fds131966}
}
@article{fds131985,
Author = {JM Provenzale and S Mukherji and NB Allen and M Castillo and AW
Weber},
Title = {Orbital involvement by Wegener's granulomatosis: imaging
findings.},
Journal = {AJR. American journal of roentgenology},
Volume = {166},
Number = {4},
Pages = {929-34},
Year = {1996},
Month = {April},
ISSN = {0361-803X},
Keywords = {Aged • Female • Humans • Magnetic Resonance
Imaging • Male • Middle Aged • Orbit •
Orbital Diseases • Retrospective Studies •
Tomography, X-Ray Computed • Wegener Granulomatosis
• diagnosis* • pathology •
radiography},
Abstract = {OBJECTIVE: The purpose of this study was to define patterns
of Wegener's granulomatosis (WG) orbital disease
involvement. METHODS: We evaluated the orbital examinations
of 14 WG patients (CT for nine, MR imaging for three, and
both CT and MR imaging for two) for the number of involved
orbits, intraconal or extraconal location, involvement of
the orbital apex, sinus involvement, bony erosion, and optic
nerve compression. MR images were analyzed for signal
characteristics and enhancement patterns. RESULTS: We found
orbital disease to be unilateral in 12 patients (86%) and
bilateral in two patients (14%) (total of 16 orbits). In 11
orbits (69%), coexistent orbital and sinus diseases with
bony erosion were present. Orbital disease without sinus
disease was seen in five orbits (31%). Intraorbital disease
distribution was as follows: solely extraconal--seven orbits
(44%) (four with involvement of muscle); intraconal with
muscular involvement--one orbit (6%); combined intra- and
extraconal--seven orbits (44%); and primarily orbital
apex--one orbit (6%). Involvement of the apex was seen in
six orbits. The WG mass was hypointense relative to orbital
fat on three standard T2-weighted MR images. We saw
homogeneous MR contrast enhancement in all four orbits
studied on enhanced T1-weighted images. CONCLUSIONS:
Intraorbital WG involvement is usually accompanied by
paranasal sinus disease. A hypointense signal on T2-weighted
MR images is helpful in suggesting the diagnosis.},
Language = {eng},
Key = {fds131985}
}
@article{fds132114,
Author = {JM Provenzale and NB Allen},
Title = {Wegener granulomatosis: CT and MR findings.},
Journal = {AJNR. American journal of neuroradiology, UNITED
STATES},
Volume = {17},
Number = {4},
Pages = {785-92},
Year = {1996},
Month = {April},
ISSN = {0195-6108},
Keywords = {Adult • Aged • Brain • Brain Ischemia •
Cerebral Arterial Diseases • Diagnosis, Differential
• Dura Mater • Female • Humans •
Magnetic Resonance Imaging* • Male • Middle Aged
• Neurologic Examination • Orbit • Paranasal
Sinuses • Retrospective Studies • Sensitivity and
Specificity • Tomography, X-Ray Computed* •
Wegener Granulomatosis • diagnosis • diagnosis*
• pathology • pathology*},
Abstract = {PURPOSE: To demonstrate the spectrum of CT and MR imaging
findings in patients with Wegener granulomatosis and to
determine how often these findings could be attributed to
either direct extension from paranasal or orbital disease
sites, remote granulomas, or central nervous system (CNS)
vasculitis. METHODS: We retrospectively reviewed the CT or
MR studies of 15 patients with Wegener granulomatosis.
RESULTS: Abnormal findings were seen in 7 patients (5
examined with MR imaging, 2 with CT). Findings included
dural thickening and contrast enhancement (3 patients),
infarcts (2 patients), regions of hyperintense signal on
T2-weighted MR images (2 patients), and abnormal MR signal
in the brain stem (2 patients). Three patients with imaging
findings of dural enhancement and thickening were thought to
have remote granulomatous lesions involving the dura. No
patients had extension from sites external to the CNS or
clinical findings suggestive of CNS vasculitis. CONCLUSION:
The spectrum of CT and MR findings in Wegener granulomatosis
includes dural thickening and enhancements cerebral
infarction, and MR signal abnormalities in the brain stem
and white matter. Presumed remote granulomatous lesions were
the most common causes of CNS findings in this study.
Complications related to non-CNS disease (eg, hypertension,
endocarditis) also appear to have played a role in some
patients.},
Key = {fds132114}
}
@article{fds132144,
Author = {JM Provenzale and RE McLendon},
Title = {Spinal angiolipomas: MR features.},
Journal = {AJNR. American journal of neuroradiology, UNITED
STATES},
Volume = {17},
Number = {4},
Pages = {713-9},
Year = {1996},
Month = {April},
ISSN = {0195-6108},
Keywords = {Adult • Angiolipoma • Diagnosis, Differential
• Epidural Neoplasms • Epidural Space •
Female • Humans • Magnetic Resonance Imaging*
• Middle Aged • diagnosis* • pathology •
surgery},
Abstract = {PURPOSE: To determine the MR features of spinal angiolipomas
and to compare these findings with their histologic
appearance. METHODS: The MR examinations of three patients
with surgically proved angiolipomas were reviewed for tumor
location and extent, signal characteristics, and pattern of
contrast enhancement, and were then compared with the
histologic findings. RESULTS: Four tumors were found in the
three patients, all located in the posterior epidural
compartment, averaging about 2.5 vertebral bodies in length.
On noncontrast T1-weighted images, all lesions were
inhomogeneous and hypointense relative to epidural fat.
Inhomogeneous enhancement was seen in three lesions on
postcontrast T1-weighted images obtained with fat-saturation
techniques. Angiolipomas were least conspicuous on
T2-weighted images. A high vascular content correlated with
the presence of large hypointense regions on T1-weighted
images. CONCLUSION: Spinal angiolipomas are typically
hyperintense on noncontrast T-1-weighted images relative to
other tumors. Angiolipomas that contain large hypointense
foci on noncontrast T1-weighted images can be expected to
have a high degree of vascularity.},
Key = {fds132144}
}
@article{fds132146,
Author = {DJ Madden and TG Turkington and RE Coleman and JM Provenzale and TR
DeGrado, JM Hoffman},
Title = {Adult age differences in regional cerebral blood flow during
visual world identification: evidence from H215O
PET.},
Journal = {NeuroImage},
Volume = {3},
Number = {2},
Pages = {127-42},
Year = {1996},
Month = {April},
ISSN = {1053-8119},
Keywords = {Adolescent • Adult • Aged • Aging •
Attention • Brain • Brain Mapping* • Female
• Humans • Image Processing, Computer-Assisted*
• Male • Mental Recall • Middle Aged •
Reading* • Reference Values • Regional Blood Flow
• Tomography, Emission-Computed* • Verbal Learning
• blood supply* • physiology •
physiology*},
Abstract = {We used H215O PET to investigate adult age differences in
regional cerebral blood flow (rCBF) during the performance
of a visual word identification task. The study participants
were 20 healthy, right-handed men: 10 young adults between
18 and 27 years of age, and 10 older adults between 63 and
75 years of age. The word identification task comprised six
blocks of test trials representing four task conditions;
subjects responded manually. The task conditions varied with
regard to whether semantic retrieval was required (e.g.,
word/nonword discrimination vs simple response to each
stimulus) and with regard to the difficulty of visual
encoding (e.g., words presented normally vs words with
asterisks inserted between adjacent letters). Each subject
performed all six trial blocks, concurrently with each of
six H215O PET scans. Analyses of quantitative CBF data
obtained from the arterial time-activity curve demonstrated
a significant age-related decline in global CBF rate.
Analyses of the changes in rCBF between task conditions
indicated that retrieval of semantic information sufficient
to distinguish words from nonwords is mediated by a ventral
occipitotemporal cortical pathway. Specific areas within
this pathway were also associated with visual encoding
processes. Several rCBF activations were significantly
greater for young adults than for older adults, indicating
an age-related decline in processing efficiency within this
ventral occipitotemporal pathway. Although the performance
data demonstrated a greater age-related slowing for visual
encoding than for semantic retrieval, these age-related
performance changes were not associated with corresponding
changes in rCBF activation.},
Language = {eng},
Key = {fds132146}
}
@article{fds132119,
Author = {G Worley and CW Erwin and RF Goldstein and JM Provenzale and RE
Ware},
Title = {Delayed development of sensorineural hearing loss after
neonatal hyperbilirubinemia: a case report with brain
magnetic resonance imaging.},
Journal = {Developmental medicine and child neurology},
Volume = {38},
Number = {3},
Pages = {271-7},
Year = {1996},
Month = {March},
ISSN = {0012-1622},
Keywords = {Cochlea • Evoked Potentials, Auditory, Brain Stem
• Globus Pallidus • Hearing Loss, Sensorineural
• Humans • Hyperbilirubinemia • Infant •
Magnetic Resonance Imaging* • Male •
Vestibulocochlear Nerve • complications* •
diagnosis* • etiology* • physiopathology},
Abstract = {Sensorineural hearing loss has long been known to be a
clinical consequence of kernicterus. Brainstem auditory
evoked potentials (BAEPs) that occur in hyperbilirubinemic
infants, can be reversed in the neonatal period by exchange
transfusion. The case was reported in an infant with
neonatal hyperbilirubinemia from hemolysis due to
glucose-6-phosphate dehydrogenase (G6PD) deficiency and
napthalene exposure. BAEPs showed that the baby had normal
hearing at 30 decibels at 13 days of age, after exchange
transfusions, but had developed profound bilateral
sensorineural hearing loss by 7 months of age. The brain
magnetic resonance imaging (MRI) findings at 7 months are
also presented.},
Language = {eng},
Key = {fds132119}
}
@article{fds132157,
Author = {JM Provenzale and K VanLandingham},
Title = {Cerebral infarction associated with Kearns-Sayre
syndrome-related cardiomyopathy.},
Journal = {Neurology},
Volume = {46},
Number = {3},
Pages = {826-8},
Year = {1996},
Month = {March},
ISSN = {0028-3878},
Keywords = {Adult • Cardiomyopathy, Dilated • Cerebral
Infarction • Diseases in Twins •
Electrocardiography • Humans • Kearns-Sayre
Syndrome • Male • Tomography, X-Ray Computed
• complications* • diagnosis •
radiography},
Abstract = {We present the clinical and neuroradiologic findings of a
31-year-old man with Kearns-Sayre syndrome- related dilated
cardiomyopathy who experienced a left middle cerebral artery
territory stroke, thought to be due to cardiogenic embolism.
The rate of clinically apparent cardiomyopathy in
Kearns-Sayre patients can be expected to increase as their
survival is prolonged by the use of cardiac pacemaker
devices. Under these circumstances, stroke caused by
cardiogenic embolism, which is presently rare, may become
more common.},
Language = {eng},
Key = {fds132157}
}
@article{fds132126,
Author = {FM Zalduondo and JM Provenzale and C Hulette and JP
Gorecki},
Title = {Meningitis, vasculitis, and cerebritis caused by CNS
histoplasmosis: radiologic-pathologic correlation.},
Journal = {AJR. American journal of roentgenology},
Volume = {166},
Number = {1},
Pages = {194-6},
Year = {1996},
Month = {January},
ISSN = {0361-803X},
Keywords = {Cerebrovascular Disorders • Encephalitis • Female
• Histoplasmosis • Humans • Meningitis,
Fungal • Middle Aged • Vasculitis • etiology
• pathology • radiography •
radiography*},
Language = {eng},
Key = {fds132126}
}
@article{fds131918,
Title = {Provenzale JM, VanLandingham K. Cerebral infarction
associated with Kearns-Sayre syndrome-related
cardiomyopathy. Neurology 1996;46(3):826-828.
(Mar)},
Year = {1996},
Key = {fds131918}
}
@article{fds131919,
Title = {Zalduondo FM, Provenzale JM, Hulette C, Gorecki JP.
Meningitis, vasculitis, and cerebritis caused by CNS
histoplasmosis: Radiologic-pathalogic correlation. AJR
1996;166:194-196. (Jan)},
Year = {1996},
Key = {fds131919}
}
@article{fds131920,
Title = {Provenzale JM, McLendon RE. Spinal angiolipoma: MR features.
AJNR 1996;17:713-719 (Apr)},
Year = {1996},
Key = {fds131920}
}
@article{fds131921,
Title = {Provenzale JM, Allen NB. Neuroradiologic findings in
polyarteritis nodosa. AJNR 1996;17:1119-1126.
(Jun-Jul)},
Year = {1996},
Key = {fds131921}
}
@article{fds131922,
Title = {Berkoben M, Provenzale JM. Hootkins RE (ed). A hemodialysis
patient with excruciating back pain. Seminars in Dialysis
1996;9:286-288. (May-Jun)},
Year = {1996},
Key = {fds131922}
}
@article{fds131923,
Title = {Letters/Replies:},
Year = {1996},
Key = {fds131923}
}
@article{fds131924,
Title = {2. Provenzale JM. Spinal epidural hematoma. In Duke
Radiology Teaching File. Provenzale JM, Nelson RC (eds).
Philadelphia, Lippincott-Raven, Inc. 1996 (in
press).},
Year = {1996},
Key = {fds131924}
}
@article{fds131925,
Title = {6. Provenzale JM. Germinoma. In Duke Radiology Teaching
File. Provenzale JM, Nelson RC (eds). Philadelphia,
Lippincott-Raven, Inc. 1996 (in press)},
Year = {1996},
Key = {fds131925}
}
@article{fds131926,
Title = {Selected Abstracts:},
Year = {1996},
Key = {fds131926}
}
@article{fds131927,
Title = {1. Provenzale JM, Mukherji SK, Allen NB, Castillo M, Weber
AL. Patterns of orbital involvement in Wegener's disease.
Presentation at the 1996 meeting of the American Roentgen
Ray Society, San Diego, CA},
Year = {1996},
Key = {fds131927}
}
@article{fds131928,
Title = {2. Provenzale JM, Ortel TL, Allen NB. The spectrum of
neuroradiologic abnormalities in patients with the
antiphospholipid syndrome. Presentation at the 1996 meeting
of the American Roentgen Ray Society, San Diego,
CA},
Year = {1996},
Key = {fds131928}
}
@article{fds131929,
Title = {4. Provenzale JM. Antiphospholipid antibodies -- Are they a
risk factor for early ischemic cerebrovascular disease?
Presentation at the 1996 meeting of the Southeastern
Neuroradiological Society, West Palm Beach,
FL},
Year = {1996},
Key = {fds131929}
}
@article{fds132008,
Title = {1. Provenzale JM, Morgenlander JC, Gress D. Spontaneous
vertebral artery dissection: Clinical, conventional
angiographic, CT and MR findings. J Comput Assist Tomogr
1996;20:185-193. (Mar-Apr)},
Year = {1996},
Key = {fds132008}
}
@article{fds132028,
Title = {Worley G, Erwin CW, Goldstein RF, Provenzale JM, Ware RE.
Delayed development of sensorineural hearing loss after
neonatal hyperbilirubinemia: A case report with brain
Magnetic Resonance Imaging. Development Med Child Neurol
1996 ;38(3):271-278. (Mar)},
Year = {1996},
Key = {fds132028}
}
@article{fds132029,
Title = {Provenzale JM, Glass JP. MRI in hemiballismus due to
subthalamic nucleus hemorrhage: an unusual complication of
liver transplantation. Neuroradiology 1996 ;38:75-77.
(May)},
Year = {1996},
Key = {fds132029}
}
@article{fds132030,
Title = {Provenzale JM, Morgenlander JC, Gress D. Spontaneous
vertebral artery dissection: Clinical, conventional
angiographic, CT and MR findings. J Comput Assist Tomogr
1996;20:185-193. (Mar-Apr)},
Year = {1996},
Key = {fds132030}
}
@article{fds132031,
Title = {Provenzale JM, Allen NB. Wegener granulomatosis: CT and MR
findings. AJNR 1996;17:785-792. (Apr)},
Year = {1996},
Key = {fds132031}
}
@article{fds132032,
Title = {Provenzale JM, Gorecki JP, Koen JL. Cerebral aneurysms
associated with seizures but without clinical signs of
rupture: Distinctive MRI findings. AJR 1996;167:230-232.
(Jul)},
Year = {1996},
Key = {fds132032}
}
@article{fds132033,
Title = {Provenzale JM, Mukherji SK, Allen NB, Castillo M, Weber AL.
Orbital involvement by Wegener's granulomatosis: Imaging
findings. AJR 1996;166:929-934. (Apr).},
Year = {1996},
Key = {fds132033}
}
@article{fds132034,
Title = {Madden DJ, Turkington TG, Coleman RE, Provenzale JM, DeGrado
TR, Hoffman JM. Adult age differences in regional cerebral
blood flow during visual world identification: Evidence from
H2 15O PET. NeuroImage 1996;3:127-142. (Apr)},
Year = {1996},
Key = {fds132034}
}
@article{fds132035,
Title = {1. Provenzale JM, Ortel TL, Nelson PC. The concentric-ring
sign revisited - Reply. AJR 1996;166:1493
(June)},
Year = {1996},
Key = {fds132035}
}
@article{fds132036,
Title = {1. Provenzale JM. Collid cyst. In Duke Radiology Teaching
File. Provenzale JM, Nelson RC (eds). Philadelphia,
Lippincott-Raven, Inc. 1996 (in press)},
Year = {1996},
Key = {fds132036}
}
@article{fds132037,
Title = {3. Provenzale JM. Cavernous angioma. In Duke Radiology
Teaching File. Provenzale JM, Nelson RC (eds). Philadelphia,
Lippincott-Raven, Inc. 1996 (in press)},
Year = {1996},
Key = {fds132037}
}
@article{fds132038,
Title = {4. Provenzale JM. Carotid dissection. In Duke Radiology
Teaching File. Provenzale JM, Nelson RC (eds). Philadelphia,
Lippincott-Raven, Inc. 1996 (in press)},
Year = {1996},
Key = {fds132038}
}
@article{fds132039,
Title = {5. Provenzale JM. Agenesis of the corpus callosum. In Duke
Radiology Teaching File. Provenzale JM, Nelson RC (eds).
Philadelphia, Lippincott-Raven, Inc. 1996 (in
press)},
Year = {1996},
Key = {fds132039}
}
@article{fds132040,
Title = {7. Provenzale JM. Epidermoid tumor. In Duke Radiology
Teaching File. Provenzale JM, Nelson RC (eds). Philadelphia,
Lippincott-Raven, Inc. 1996 (in press)},
Year = {1996},
Key = {fds132040}
}
@article{fds132041,
Title = {8. Provenzale JM. Multiple sclerosis. In Duke Radiology
Teaching File. Provenzale JM, Nelson RC (eds). Philadelphia,
Lippincott-Raven, Inc. 1996 (in press)},
Year = {1996},
Key = {fds132041}
}
@article{fds132042,
Title = {3. Esposito M, Provenzale JM. Prevalence of arterial
dissection associated with carotid canal fracture.
Presentation at the 1996 meeting of the American Roentgen
Ray Society, San Diego, CA},
Year = {1996},
Key = {fds132042}
}
@article{fds132043,
Title = {5. Provenzale JM, Allen NB, Ortel TL. Brain CT and MR
imaging findings in patients with antiphospholipid
antibodies. Presentation at the VII International Symposium
on Antiphospholipid Antibodies, New Orleans, LA, October
1996},
Year = {1996},
Key = {fds132043}
}
@article{fds131979,
Author = {JM Provenzale},
Title = {Dissection of the internal carotid and vertebral arteries:
imaging features.},
Journal = {AJR. American journal of roentgenology, UNITED
STATES},
Volume = {165},
Number = {5},
Pages = {1099-104},
Year = {1995},
Month = {November},
ISSN = {0361-803X},
Keywords = {Aneurysm, Dissecting • Carotid Artery Diseases •
Carotid Artery, Internal • Humans • Magnetic
Resonance Angiography • Magnetic Resonance Imaging
• Tomography, X-Ray Computed • Vertebral Artery*
• diagnosis* • pathology •
radiography},
Abstract = {Dissection of either the internal carotid artery or the
vertebral artery (cervicocephalic arterial dissection) was
once considered uncommon. However, in the past few decades,
it has been increasingly recognized as a cause of stroke in
young and middle-aged adults. Dissection causes only
0.4-2.5% of all strokes in the general population but causes
5-20% of strokes among young patients. Anticoagulant therapy
is usually started immediately after the dissection is
diagnosed. The clinical and radiologic features are
important to recognize so that anticoagulation therapy can
be started promptly, thereby minimizing the risks of
infarction, permanent neurologic disability, and
death.},
Key = {fds131979}
}
@article{fds131997,
Author = {DM Furie and JM Provenzale},
Title = {Supratentorial ependymomas and subependymomas: CT and MR
appearance.},
Journal = {Journal of computer assisted tomography},
Volume = {19},
Number = {4},
Pages = {518-26},
Year = {1995},
Month = {August},
ISSN = {0363-8715},
Keywords = {Adolescent • Brain • Ependymoma • Female
• Glioma, Subependymal • Humans • Magnetic
Resonance Imaging • Male • Middle Aged •
Retrospective Studies • Supratentorial Neoplasms •
Tomography, X-Ray Computed • diagnosis* •
epidemiology • pathology* • radiography},
Abstract = {OBJECTIVE: Our goal was to characterize the CT and MR
features of supratentorial ependymomas and subependymomas.
METHODS: The CT or MRI examinations of 11 supratentorial
ependymomas (average patient age: 16 years) and 3
supratentorial subependymomas (average age: 60 years) were
analyzed for tumor size, location, and appearance. RESULTS:
Ependymomas were periventricular (nine), intraventricular
(one), or both (one) and averaged 4 cm in diameter. Four of
nine ependymomas examined by CT were calcified. Eight
ependymomas had a cystic component. All seven ependymomas
evaluated with MRI demonstrated prolonged T1 and T2
relaxation, with two having foci thought to represent
intratumoral hemorrhage. The MR contrast enhancement
patterns included an enhancing nodule within the wall of a
cyst (four), heterogeneous enhancement of cystic/solid
lesions (two), and homogeneous enhancement of a solid lesion
(one). All subependymomas were solid intraventricular
masses, averaging 2.6 cm in diameter. One had small amounts
of calcification, and none were cystic. All three were
isointense or hypointense to white matter on T1-weighted MR
images and heterogeneous or hyperintense on T2-weighted
images, with variable enhancement characteristics. Early (<
1 year) postsurgical recurrence was seen in two ependymomas
and one subependymoma. CONCLUSIONS: Supratentorial
ependymomas are typically large, cystic, calcified,
extraventricular masses found in children and young adults.
Supratentorial subependymomas are generally solid,
intraventricular masses that are usually smaller than
ependymomas and occur in an order patient
population.},
Language = {eng},
Key = {fds131997}
}
@article{fds131980,
Author = {JM Provenzale and TL Ortel},
Title = {Anatomic distribution of venous thrombosis in patients with
antiphospholipid antibody: imaging findings.},
Journal = {AJR. American journal of roentgenology, UNITED
STATES},
Volume = {165},
Number = {2},
Pages = {365-8},
Year = {1995},
Month = {August},
ISSN = {0361-803X},
Keywords = {Adolescent • Adult • Antibodies, Antiphospholipid
• Antiphospholipid Syndrome • Female • Humans
• Lupus Coagulation Inhibitor • Magnetic Resonance
Angiography • Magnetic Resonance Imaging • Male
• Middle Aged • Pulmonary Embolism •
Recurrence • Retrospective Studies •
Thrombophlebitis • Tomography, X-Ray Computed •
blood • complications • diagnosis •
diagnosis* • etiology},
Abstract = {OBJECTIVE. Antiphospholipid antibodies are immunoglobulins
that cross-react with phospholipid within cell membranes.
These antibodies have been associated with a hypercoagulable
state manifested by early stroke, frequent arterial and
venous thromboses, recurrent fetal loss, thrombocytopenia,
and livedo reticularis (antiphospholipid syndrome). The
purpose of this study was to determine the anatomic
distribution of venous thrombosis in patients with
antiphospholipid antibodies as seen on imaging examinations.
MATERIALS AND METHODS. We retrospectively reviewed the
laboratory results of patients tested for antiphospholipid
antibodies at a tertiary referral center during the period
January 1992 to April 1994. This review revealed 228
patients with antiphospholipid antibodies. We excluded
patients with systemic lupus erythematosus or any other
medical condition associated with a hypercoagulable state
and patients over 65 years old. Thirty-one of the remaining
73 patients had undergone imaging studies of the CNS or
non-CNS venous system. Radiologic studies (contrast
angiography or venography, MR angiography or venography, or
Doppler sonography) were examined for the presence of venous
thrombosis. Nineteen patients--11 men and eight women, 18-62
years old (average age, 38 years)--with venous thromboses
were identified. RESULTS. Twelve patients had non-CNS
thrombosis alone, three had CNS thrombosis alone, and four
had both CNS and non-CNS thromboses. Locations of non-CNS
thromboses included deep veins of the legs (nine
occurrences), pulmonary vessels (five), and large veins in
the thorax or abdomen (six). Three of these patients had
documented thromboses at other sites. Twelve patients had
recurrent thrombotic events (six with multiple recurrences),
including five with arterial thromboses and two with both
venous and arterial thromboses and stroke. Among patients
with CNS involvement, five had documented thromboses (four
dural sinus, one arterial) and two had arterial distribution
strokes demonstrated by CT. Two patients with only non-CNS
thromboses had either seizures or migraines. CONCLUSION.
Deep veins of the leg were the most common site of venous
thrombosis. The thoracic and abdominal venous system and the
dural sinuses--unusual sites of thrombosis in the general
population--are other common sites. Antiphospholipid
antibodies should be suspected when thromboses are found in
these locations in the absence of other known risk factors,
or when found in combination with arterial thromboses or CNS
ischemic disease in young or middle-aged
patients.},
Key = {fds131980}
}
@article{fds132147,
Author = {JM Provenzale and TL Ortel and RC Nelson},
Title = {Adrenal hemorrhage in patients with primary antiphospholipid
syndrome: imaging findings.},
Journal = {AJR. American journal of roentgenology, UNITED
STATES},
Volume = {165},
Number = {2},
Pages = {361-4},
Year = {1995},
Month = {August},
ISSN = {0361-803X},
Keywords = {Abdomen • Adrenal Gland Diseases • Adult •
Aged • Antiphospholipid Syndrome • Female •
Hemorrhage • Humans • Magnetic Resonance Imaging
• Male • Middle Aged • Radiography, Abdominal
• Retrospective Studies • Risk Factors •
Tomography, X-Ray Computed • complications •
diagnosis* • etiology • pathology},
Abstract = {OBJECTIVE. The primary antiphospholipid syndrome consists of
recurrent thromboses, early stroke, recurrent fetal loss,
and livedo reticularis in patients with antiphospholipid
antibodies and without systemic lupus erythematosus. The
purpose of this study was to analyze the imaging findings in
patients who had this syndrome as well as adrenal
hemorrhage. MATERIALS AND METHODS. The medical records and
reports of radiologic examinations of 228 patients with
elevated titers of lupus anticoagulant or anticardiolipin
antibodies from January 1992 to April 1994 were examined for
indications of adrenal hemorrhage. Four patients (two men
and two women 38-78 years old) were identified as having
adrenal hemorrhage. The abdominal CT and MR imaging findings
for three patients and autopsy data for the fourth patient
were analyzed. RESULTS. Adrenal hemorrhage was seen in all
three patients who underwent abdominal CT and in one patient
who underwent MR imaging. Adrenal hemorrhage was bilateral
in three patients. Extension of hemorrhage into the
perinephric space was present in two patients. Associated
clinical findings probably attributable to the presence of
antiphospholipid antibodies included amaurosis fugax (two
patients), deep venous thrombosis (three patients), and
transient ischemic attacks or stroke (two patients).
CONCLUSION. Antiphospholipid antibodies appear to be a risk
factor for adrenal hemorrhage. The presence of these
antibodies should be suspected in patients who have adrenal
hemorrhage as well as recurrent thromboses and early
stroke.},
Key = {fds132147}
}
@article{fds131977,
Author = {SH Wray and JM Provenzale and DR Johns and KR Thulborn},
Title = {MR of the brain in mitochondrial myopathy.},
Journal = {AJNR. American journal of neuroradiology, UNITED
STATES},
Volume = {16},
Number = {5},
Pages = {1167-73},
Year = {1995},
Month = {May},
ISSN = {0195-6108},
Keywords = {Adult • Atrophy • Brain • Brain Damage,
Chronic • Cerebellum • Cerebral Cortex •
Female • Humans • Kearns-Sayer Syndrome •
Magnetic Resonance Imaging* • Male • Middle Aged
• Mitochondrial Myopathies • Ophthalmoplegia,
Chronic Progressive External • Prospective Studies
• diagnosis • diagnosis* • pathology •
pathology*},
Abstract = {PURPOSE: To determine the spectrum of MR findings in
patients with mitochondrial myopathy and correlate them with
central nervous system symptoms and signs. METHODS: We
performed a prospective evaluation of the MR findings of
eight patients with mitochondrial myopathy (three with
Kearns-Sayre syndrome and five with chronic progressive
external ophthalmoplegia), six of whom had central nervous
system symptoms or signs (ataxia, sensorineural hearing
loss, or cognitive dysfunction). RESULTS: All six patients
with neurologic symptoms or signs had multiple abnormal MR
findings, whereas patients without neurologic symptoms had
either normal MR findings (one patient) or the solitary
finding of cortical atrophy (one patient). Abnormal MR
findings consisted of cerebral cortical atrophy (seven
patients), cerebellar atrophy (six patients), and
hyperintense signal abnormalities on T2-weighted images
within the cerebral white matter (three patients),
cerebellar white matter (one patient), basal ganglia (three
patients), brain stem (one patient), and thalamus (one
patient). In two patients, the cerebral white matter signal
abnormalities were primarily peripheral and involved the
arcuate fibers. All patients with ataxia had abnormal
cerebellar findings on MR imaging, but there was poor
correlation between other neurologic features and MR
findings. CONCLUSIONS: Cerebral and cerebellar atrophy are
the most common MR findings in Kearns-Sayre syndrome and
chronic progressive external ophthalmoplegia. White matter
and deep gray nuclei abnormalities, presumed to result from
the diffuse spongiform encephalopathy reported in these
patients, can also be seen. Patients with abnormal
neurologic findings typically have multiple abnormalities on
MR imaging, which frequently do not correlate with specific
symptoms.},
Key = {fds131977}
}
@article{fds132152,
Author = {JM Provenzale and DP Barboriak and JM Taveras},
Title = {Exercise-related dissection of craniocervical arteries: CT,
MR, and angiographic findings.},
Journal = {Journal of computer assisted tomography},
Volume = {19},
Number = {2},
Pages = {268-76},
Year = {1995},
Month = {April},
ISSN = {0363-8715},
Keywords = {Adolescent • Adult • Aneurysm, Dissecting •
Athletic Injuries • Carotid Artery Diseases •
Carotid Artery, Internal • Cerebral Infarction •
Craniocerebral Trauma • Exercise* • Female •
Humans • Magnetic Resonance Angiography* •
Magnetic Resonance Imaging* • Male • Middle Aged
• Neck Injuries • Tomography, X-Ray Computed*
• Vertebral Artery* • complications •
diagnosis • diagnosis* • etiology •
radiography},
Abstract = {OBJECTIVE: Our goal was to demonstrate the spectrum of
neuroradiologic (CT, MR, and angiographic) findings in
craniocervical arterial dissection (CAD) related to exercise
or sporting activities and compare the diagnostic utility of
CT, MRI, and MR angiography (MRA). METHODS: The
neuroradiologic examinations of 11 patients with CAD was
performed: CT was performed in 10 patients, cranial MRI in
9, cranial and cervical MRA in 4, and contrast angiography
in 10. The CT examinations were assessed for the presence of
an infarction or a hyperdense artery (consistent with
intraluminal thrombus), MRI examinations for the presence of
infarction or abnormal periarterial signal, and contrast
angiograms for arterial stenosis or occlusion, luminal
irregularity, pseudoaneurysm, intimal flap, or distal branch
occlusions. RESULTS: Computed tomography demonstrated
infarction in four patients. At contrast angiography, a
dissection was found in the artery supplying the region of
infarction in all cases. A hyperdense artery was found by CT
in two patients, which correlated with dissection of the
artery or its parent artery on contrast angiography. Cranial
MRI findings were seen in six patients (infarction in five,
periarterial signal abnormality in five). Dissection was
confirmed in all four patients with abnormal periarterial
signal who underwent contrast angiography. Two patients with
abnormal intracranial periarterial signal had corresponding
abnormalities on MRA. False-negative cranial and cervical
MRI and MRA studies were performed in one patient because
the imaging volumes used for the cervical and intracranial
MR examinations did not overlap. Four patients with normal
intracranial arterial signal had dissection in the neck
demonstrated by contrast angiography. CONCLUSIONS:
Neuroradiologic findings of CAD can include infarction, a
hyperdense artery on CT, abnormal periarterial signal on
MRI, and a narrowed arterial signal column on MRA. Computed
tomography is an insensitive screening examination. Proper
use of MRI and MRA involves examination of both the head and
the neck with overlapping imaging volumes of the two
regions.},
Language = {eng},
Key = {fds132152}
}
@article{fds131993,
Author = {JM Provenzale and DP Barboriak and K Sims},
Title = {Neuroradiologic findings in fucosidosis, a rare lysosomal
storage disease.},
Journal = {AJNR. American journal of neuroradiology, UNITED
STATES},
Volume = {16},
Number = {4 Suppl},
Pages = {809-13},
Year = {1995},
Month = {April},
ISSN = {0195-6108},
Keywords = {Biopsy • Brain • Brain Diseases, Metabolic •
Cerebral Ventricles • Child • Child, Preschool
• Female • Fucosidosis • Globus Pallidus
• Humans • Lysosomes • Magnetic Resonance
Imaging* • Male • Neurologic Examination •
Skin • Tomography, X-Ray Computed* • diagnosis*
• genetics • pathology • pathology* •
ultrastructure},
Abstract = {Fucosidosis is a rare lysosomal storage disorder with the
clinical features of mental retardation, cardiomegaly,
dysostosis multiplex, progressive neurologic deterioration,
and early death. The neuroradiologic findings in two
patients are reported, and include abnormalities within the
globus pallidus (both patients) and periventricular white
matter (one patient).},
Key = {fds131993}
}
@article{fds131995,
Author = {VS Lee and JM Provenzale and HE Fuchs and A Osumi and RE
McLendon},
Title = {Post-traumatic epidermoid cyst: CT appearance.},
Journal = {Journal of computer assisted tomography},
Volume = {19},
Number = {1},
Pages = {153-5},
Year = {1995},
Month = {February},
ISSN = {0363-8715},
Keywords = {Adolescent • Brain Diseases • Epidermal Cyst
• Humans • Intracranial Aneurysm • Male
• Skull Fractures • Time Factors •
Tomography, X-Ray Computed • complications* •
etiology • etiology* • radiography •
radiography*},
Abstract = {We report development of an intracranial epidermoid cyst 2
years after a depressed skull fracture. The epidermoid cyst
is presumed to be the result of introduction of epidermal
elements at the time of trauma. Post-traumatic intracranial
epidermoid cysts are rare and appear to be less common than
those occurring in the spine.},
Language = {eng},
Key = {fds131995}
}
@article{fds132110,
Author = {JM Provenzale and L Hacein-Bey and JM Taveras},
Title = {Internal carotid artery dissection associated with pituitary
apoplexy: MR findings.},
Journal = {Journal of computer assisted tomography},
Volume = {19},
Number = {1},
Pages = {150-2},
Year = {1995},
Month = {February},
ISSN = {0363-8715},
Keywords = {Adult • Aneurysm, Dissecting • Carotid Artery
Diseases • Carotid Artery, Internal • Humans
• Intracranial Aneurysm • Magnetic Resonance
Angiography • Magnetic Resonance Imaging • Male
• Pituitary Apoplexy • complications •
diagnosis* • etiology • pathology},
Abstract = {Pituitary apoplexy almost invariably occurs following
hemorrhage into a pituitary neoplasm. We report a case in
which pituitary apoplexy occurred in the setting of, and
probably secondary to, dissection of the internal carotid
artery.},
Language = {eng},
Key = {fds132110}
}
@article{fds132003,
Author = {JM Provenzale and AL Weber and GK Klintworth and RE
McLendon},
Title = {Radiologic-pathologic correlation. Bilateral retinoblastoma
with coexistent pinealoblastoma (trilateral
retinoblastoma).},
Journal = {AJNR. American journal of neuroradiology},
Volume = {16},
Number = {1},
Pages = {157-65},
Year = {1995},
Month = {January},
ISSN = {0195-6108},
Keywords = {Brain Neoplasms • Child, Preschool • Eye Neoplasms
• Female • Humans • Infant, Newborn •
Magnetic Resonance Imaging* • Neoplasms, Multiple
Primary • Pineal Gland • Pinealoma •
Retinoblastoma • Tomography, X-Ray Computed* •
diagnosis* • pathology* • radiography},
Language = {eng},
Key = {fds132003}
}
@article{fds131903,
Title = {2. Provenzale JM, Ortel TL. Anatomic distribution of venous
thrombosis in patients with antiphospholipid antibodies.
Imaging findings. AJR 1995;165:365-368.},
Year = {1995},
Key = {fds131903}
}
@article{fds131904,
Title = {5. Provenzale JM, Ortel TL. Anatomic distribution of venous
thrombosis in patients with antiphospholipid antibodies:
Imaging findings. AJR 1995;165:365-368. (Aug)},
Year = {1995},
Key = {fds131904}
}
@article{fds131909,
Title = {Wray SH, Provenzale JM, Johns DR, Thulborn KR. MR of the
brain in mitochondrial myopathy. AJNR 1995;
16:1167-1173.},
Year = {1995},
Key = {fds131909}
}
@article{fds131910,
Title = {Lee VS, Provenzale JM, Fuchs HE, Osumi AK, McLendon RE.
Post-traumatic epidermoid cyst: CT appearance. J Comput
Assist Tomogr 1995; 19:153-155.},
Year = {1995},
Key = {fds131910}
}
@article{fds131911,
Title = {Provenzale JM, Barboriak DP, Taveras JM. Exercise-related
dissection of craniocervical arteries: CT, MR, and
angiographic findings. J Comput Assist Tomogr 1995;
19:268-276.},
Year = {1995},
Key = {fds131911}
}
@article{fds131912,
Title = {Furie DM, Provenzale JM. Neuroradiologic findings in
supratentorial ependymomas and subependymomas. J Comput
Assist Tomogr 1995; 19:518-526. (Jul-Aug)},
Year = {1995},
Key = {fds131912}
}
@article{fds131913,
Title = {Provenzale JM, Glass JP. Hemiballismus: CT and MR findings.
J Comput Assist Tomogr 1995; 19:537-540.
(Jul-Aug)},
Year = {1995},
Key = {fds131913}
}
@article{fds131914,
Title = {Letters/Replies:},
Year = {1995},
Key = {fds131914}
}
@article{fds131915,
Title = {Provenzale JM. Letter. Reply to: "Subthalamic nucleus vs.
Substantia nigra". AJNR 1995; 16:613.},
Year = {1995},
Key = {fds131915}
}
@article{fds131916,
Title = {Selected Abstracts:},
Year = {1995},
Key = {fds131916}
}
@article{fds131917,
Title = {2. Provenzale JM, Allen NB. MR findings in Wegener's
Granulomatosis. Presentation at the 1995 meeting of the
American Society of Neuroradiology, Chicago,
IL.},
Year = {1995},
Key = {fds131917}
}
@article{fds132009,
Title = {3. Provenzale JM. Dissection of the internal carotid and
vertebral arteries. Imaging findings. AJR
1995;165:1099-1104.},
Year = {1995},
Key = {fds132009}
}
@article{fds132016,
Title = {Provenzale JM, Weber AL, Klintworth GK, McLendon RE.
Bilateral retinoblastoma with coexistent pineoblastoma
("Trilateral retinoblastoma": Radiologic-pathologic
correlation. AJNR 1995; 16:157-165.},
Year = {1995},
Key = {fds132016}
}
@article{fds132017,
Title = {Provenzale JM, Barboriak DP, Sims K. MR imaging findings in
fucosidosis, a rare lysosomal storage disease. AJNR 1995;
16:809-813.},
Year = {1995},
Key = {fds132017}
}
@article{fds132018,
Title = {Hitchcock MG, Ellington KS, Friedman AH, Provenzale JM,
McLendon RE. Shadow cells in an intracranial dermoid cyst: a
case report. Arch Pathol Lab Med 1995; 119:371-373.},
Year = {1995},
Key = {fds132018}
}
@article{fds132019,
Title = {Provenzale JM, Hacein-Bey L, Taveras JM. Pituitary apoplexy
associated with carotid dissection: MR findings. J Comput
Assist Tomogr 1995; 19:150-152.},
Year = {1995},
Key = {fds132019}
}
@article{fds132020,
Title = {Nielsen GP, Dickerson GR, Provenzale JM, Rosenberg AE.
Lipomatous hemangiopericytoma. A histologic, ultrastructural
and immunohistochemical study of a unique variant of
hemangiopericytoma. Am J Surg Pathol 1995;
19:748-756.},
Year = {1995},
Key = {fds132020}
}
@article{fds132021,
Title = {Provenzale JM, Nelson RC, Ortel TL. Adrenal hemorrhage in
patients with the primary antihospholipid antibodies:
Imaging findings. AJR 1995; 165:361-364.
(Aug)},
Year = {1995},
Key = {fds132021}
}
@article{fds132022,
Title = {Provenzale JM, Ortel TL. Anatomic distribution of venous
thrombosis in patients with antiphospholipid antibodies.
Imaging findings. AJR 1995; 165:365-368.
(Aug)},
Year = {1995},
Key = {fds132022}
}
@article{fds132023,
Title = {Provenzale JM. Dissection of the internal cartoid and
vertebral arteries. Imaging findings. AJR 1995;
165:1099-1104. (Nov)},
Year = {1995},
Key = {fds132023}
}
@article{fds132024,
Title = {Provenzale JM. Letter. Reply to "Symmetric lesions of the
subthalamic nuclei in metochondrial encephalopathies: An
almost distinctive mark of Leigh's disease with COX
deficiency". AJNR 1995; 16:1747. (Sep)},
Year = {1995},
Key = {fds132024}
}
@article{fds132025,
Title = {Provenzale JM. Dissection of the craniocervical arteries. In
Taveras JM, Ferrucci JT. Radiology: Diagnosis-Imaging-Intervention.
Lippincott; Philadelphia, 1995.},
Year = {1995},
Key = {fds132025}
}
@article{fds132026,
Title = {1. Provenzale JM, Ortel Tl. Antiphospholipid antibody
syndrome: Neuroradiologic features. Presentation at the 1995
meeting of the Association of University Radiologists, San
Diego, CA},
Year = {1995},
Key = {fds132026}
}
@article{fds132027,
Title = {3. Madden DJ, Coleman RE, Turkington TG, Provenzale JM,
DeGrado TR, Hoffman JM. Adult age differences in the
functional neuroanatomy of visual word identification.
Presentation at the XVII International Symposium of Cerebral
Blood Flow and Metabolism, Cologne, Germany, July,
1995},
Year = {1995},
Key = {fds132027}
}
@article{fds132132,
Author = {JM Provenzale and DP Barboriak and EH Gaensler and RL Robertson and B
Mercer},
Title = {Lupus-related myelitis: serial MR findings.},
Journal = {AJNR. American journal of neuroradiology},
Volume = {15},
Number = {10},
Pages = {1911-7},
Year = {1994},
Month = {November},
ISSN = {0195-6108},
Keywords = {Adrenal Cortex Hormones • Adult • Diagnosis,
Differential • Female • Follow-Up Studies •
Humans • Immunosuppressive Agents • Lupus
Erythematosus, Systemic • Magnetic Resonance Imaging
• Middle Aged • Myelitis, Transverse •
Neurologic Examination • Retrospective Studies •
Spinal Cord • diagnosis* • drug effects •
drug therapy • methods* • pathology •
therapeutic use},
Abstract = {OBJECTIVE: To correlate the MR findings in transverse
myelitis secondary to systemic lupus erythematosus with
clinical findings during disease exacerbation and remission.
METHODS: Four patients (ages 33 to 47 years) with episodes
of transverse myelitis secondary to systemic lupus
erythematosus were identified. Three patients had recurrent
transverse myelitis episodes (one patient with two
recurrences), for a total of eight episodes. MR examinations
(six after contrast administration) were performed during
each transverse myelitis episode, as well as during four
periods of remission (in three patients) after therapy with
steroids and/or immunosuppressive agents. MR examinations
were reviewed for the presence of spinal cord enlargement,
intramedullary signal abnormality, and contrast enhancement.
RESULTS: Prolongation of T1 or T2 signal (or both) was seen
in eight episodes (100%). Spinal cord enlargement was seen
in six (75%) of eight transverse myelitis episodes, although
it was mild during two episodes. Contrast enhancement was
seen in three of six transverse myelitis episodes (dense,
inhomogeneous enhancement during two episodes in one
patient, and a small focus of enhancement in one patient).
During periods of remission, spinal cord diameter returned
to normal, and no contrast enhancement was seen, although
abnormal signal was present in three examinations performed
within 2 months of a transverse myelitis episode.
CONCLUSIONS: Spinal cord widening and signal abnormalities
are common MR findings during episodes of transverse
myelitis related to systemic lupus erythematosus, and
contrast enhancement is less frequently seen. Improvement or
resolution of these findings correlates with clinical
improvement.},
Language = {eng},
Key = {fds132132}
}
@article{fds131991,
Author = {JM Provenzale and RD Tien and GJ Felsberg and L Hacein-Bey},
Title = {Spinal dural arteriovenous fistula: demonstration using
phase contrast MRA.},
Journal = {Journal of computer assisted tomography},
Volume = {18},
Number = {5},
Pages = {811-4},
Year = {1994},
Month = {October},
ISSN = {0363-8715},
Keywords = {Angiography • Arteriovenous Fistula • Contrast
Media • Dura Mater • Humans • Magnetic
Resonance Imaging* • Male • Middle Aged •
Myelography • Spinal Cord • Tomography, X-Ray
Computed • blood supply* • diagnosis* •
methods • radiography},
Abstract = {Contrast angiography is the standard means of diagnosing
spinal dural arteriovenous fistulas. We present a patient in
whom a spinal dural arteriovenous fistula was demonstrated
on phase contrast MR angiography.},
Language = {eng},
Key = {fds131991}
}
@article{fds132143,
Author = {JM Provenzale and ER Heinz and TL Ortel and BG Macik and LA Charles and MJ
Alberts},
Title = {Antiphospholipid antibodies in patients without systemic
lupus erythematosus: neuroradiologic findings.},
Journal = {Radiology},
Volume = {192},
Number = {2},
Pages = {531-7},
Year = {1994},
Month = {August},
ISSN = {0033-8419},
Keywords = {Adult • Antibodies, Antiphospholipid • Brain
• Brain Diseases • Cerebral Angiography •
Female • Humans • Lupus Erythematosus, Systemic
• Magnetic Resonance Imaging • Male • Middle
Aged • Retrospective Studies • Tomography, X-Ray
Computed • analysis* • complications •
diagnosis • immunology • pathology •
radiography • radiography*},
Abstract = {OBJECTIVE: To study neuroradiologic findings in patients
with hypercoagulability due to antiphospholipid antibodies
(APAs). METHODS: Retrospective review of abnormal
angiographic, computed tomographic, and magnetic resonance
imaging findings was performed over a 14-month period in
patients with APAs, no diagnosis of systemic lupus
erythematosus, age less than 65 years, and no other cause of
a hypercoagulable state. RESULTS: Fourteen patients (age
range, 22-62 years) with APAs had abnormal results at
neuroradiologic examination. Abnormal findings on
cross-sectional imaging studies included large-artery (n =
3), lacunar (n = 5), and venous infarctions (n = 2);
cortical atrophy (n = 5); white matter abnormalities (n =
3); and dural sinus thrombosis (n = 4). Abnormal
angiographic findings included large-artery occlusions (n =
2), arterial narrowing that simulated vasculitis (n = 2),
and transverse sinus thrombosis (n = 1). CONCLUSIONS:
Presence of APAs should be suspected when no cause is
apparent for either (a) an ischemic cerebrovascular event in
young and middle-aged adults or (b) dural sinus or cerebral
venous thrombosis (c) in patients with recurrent systemic
arterial or venous thromboses, especially women with
recurrent miscarriages.},
Language = {eng},
Key = {fds132143}
}
@article{fds132167,
Author = {JM Provenzale and MA Schwarzschild},
Title = {Hemiballismus.},
Journal = {AJNR. American journal of neuroradiology},
Volume = {15},
Number = {7},
Pages = {1377-82},
Year = {1994},
Month = {August},
ISSN = {0195-6108},
Keywords = {AIDS-Related Opportunistic Infections • Aged •
Biopsy • Dominance, Cerebral • Humans •
Magnetic Resonance Imaging* • Male • Movement
Disorders • Neurologic Examination • Thalamus
• Toxoplasmosis, Cerebral • diagnosis* •
pathology • physiology*},
Language = {eng},
Key = {fds132167}
}
@article{fds132182,
Author = {DP Barboriak and JM Provenzale and OB Boyko},
Title = {MR diagnosis of Creutzfeldt-Jakob disease: significance of
high signal intensity of the basal ganglia.},
Journal = {AJR. American journal of roentgenology, UNITED
STATES},
Volume = {162},
Number = {1},
Pages = {137-40},
Year = {1994},
Month = {January},
ISSN = {0361-803X},
Keywords = {Adult • Aged • Basal Ganglia •
Creutzfeldt-Jakob Syndrome • Female • Humans
• Magnetic Resonance Imaging* • Male • Middle
Aged • Retrospective Studies • diagnosis* •
pathology • pathology*},
Abstract = {OBJECTIVE. Creutzfeldt-Jakob disease is a rare dementing
illness that usually affects older adults. Currently,
neuroradiologic examinations play a minor role in the
diagnosis of Creutzfeldt-Jakob disease. Several single case
reports have noted a distinctive finding of hyperintense
signal abnormalities in the basal ganglia on T2-weighted MR
images of patients with Creutzfeldt-Jakob disease. In order
to assess the diagnostic utility of this finding, we studied
the imaging features of four patients with Creutzfeldt-Jakob
disease in whom this MR finding was present. MATERIALS AND
METHODS. Two neuroradiologists retrospectively reviewed the
MR images of four patients who had pathologically proved
Creutzfeldt-Jakob disease and signal abnormalities in the
basal ganglia on T2-weighted MR images. The patients'
clinical findings were also analyzed. RESULTS. The four
patients had MR examinations between 6 months and 1 year
after the onset of symptoms. In all four cases, the
hyperintense signal abnormalities in the basal ganglia on
T2-weighted images were diffuse and bilaterally symmetric.
The T1-weighted images were normal. A CT scan was obtained
on a single patient and was normal. CONCLUSION. Although a
lack of signal abnormality in the basal ganglia on MR
imaging cannot be used to rule out a diagnosis of
Creutzfeldt-Jakob disease, our experience and review of
published reports suggest that in the proper clinical
setting, bilaterally symmetric, diffuse hyperintense
abnormalities in the basal ganglia on T2-weighted images may
be a specific sign of Creutzfeldt-Jakob disease.},
Key = {fds132182}
}
@article{fds131906,
Title = {Provenzale JM, Schwarzschild MA. Hemiballismus:
Radiologic-Clinical Correlation. AJNR 1994;
15:1377-1382.},
Year = {1994},
Key = {fds131906}
}
@article{fds131907,
Title = {Provenzale JM, Tien RD, Felsberg G, Hacein-Bey L. Spinal
dural arteriovenous fistula: Demonstration using phase
contrast magnetic resonance imaging. J Comput Assist Tomogr
1994; 18:881-814.},
Year = {1994},
Key = {fds131907}
}
@article{fds131908,
Title = {Provenzale JM, Taveras JM. "Clinical Cases in
Neuroradiology", Philadelphia: Lea & Febiger
Co.,1994.},
Year = {1994},
Key = {fds131908}
}
@article{fds132010,
Title = {4. Provenzale JM, Heinz ER, Ortel TL, Macik CG, Alberts MJ.
Neuroradiologic findings in non-SLE patients with
antiphospholipid antibodies. Radiology 1994;192:531-537.},
Year = {1994},
Key = {fds132010}
}
@article{fds132011,
Title = {Provenzale JM. Neuroradiologic findings in intracranial
trauma. Appl Radiol 1994;23:11-20.},
Year = {1994},
Key = {fds132011}
}
@article{fds132012,
Title = {Barboriak DP, Provenzale JM, Boyko OB. MR diagnosis of
Creutzfeld-Jakob disease: Significance of high signal
abnormality of the basal ganglia. AJR 1994;
162:137-140.},
Year = {1994},
Key = {fds132012}
}
@article{fds132013,
Title = {Provenzale JM, Heinz ER, Ortel TL, Macik CG, Alberts MJ.
Neuroradiologic findings in non-SLE patients with
antiphospholipid antibodies. Radiology 1994;
192:531-537.},
Year = {1994},
Key = {fds132013}
}
@article{fds132014,
Title = {Provenzale JM, Loganbill H. Dural sinus thrombosis and
hemorrhagic venous infarction associated with
antiphospholipid antibodies: MR findings. J Comput Assist
Tomogr 1994; 18:881-814.},
Year = {1994},
Key = {fds132014}
}
@article{fds132015,
Title = {Provenzale JM, Barboriak DP, Gaensler EH, Robertson RL,
Mercer B. Lupus-related myelitis: Serial MR Findings. AJNR
1994; 15:1911-1917.},
Year = {1994},
Key = {fds132015}
}
@article{fds131905,
Title = {Provenzale JM. CT and MRI evaluation of intracranial tauma.
Imaging 1993;5:223-236.},
Year = {1993},
Key = {fds131905}
}
@article{fds131989,
Author = {JM Provenzale},
Title = {Treatment modalities in Guillain-Barré syndrome.},
Journal = {Hospital practice (Office ed.), UNITED STATES},
Volume = {22},
Number = {3},
Pages = {93-8, 102},
Year = {1987},
Month = {March},
ISSN = {8750-2836},
Keywords = {Animals • Cyclophosphamide • Humans • Plasma
Exchange • Polyradiculoneuropathy • Prednisone
• Respiration, Artificial • diagnosis •
physiopathology • therapeutic use • therapeutic
use* • therapy*},
Key = {fds131989}
}
@article{fds132113,
Author = {JM Provenzale},
Title = {Anorexia nervosa--thinness as illness.},
Journal = {Postgraduate medicine, UNITED STATES},
Volume = {74},
Number = {4},
Pages = {83-9},
Year = {1983},
Month = {October},
ISSN = {0032-5481},
Keywords = {Adolescent • Adult • Anorexia Nervosa •
Diagnosis, Differential • Female • Hospitalization
• Humans • Interpersonal Relations •
Psychotherapy • Self Concept • Thinness •
diagnosis* • psychology • therapy},
Abstract = {Anorexia nervosa appears to be on the rise, perhaps in part
due to the cultural ideal of a thin figure. The anorectic is
typically a highly motivated, over-compliant adolescent girl
or young woman who has had problems with self-image and
social interactions. Her behavior is an attempt to exert
control and self-direction, usually through the regulation
of food intake. Weight loss is the most common symptom of
the disease and, when extreme, can be life-threatening.
Although anorexia nervosa is usually considered a
psychologic disorder, strong evidence for biologic
relationships exists. Therapy includes both medical
treatment and some form of psychotherapy. However, while
acute problems often respond to medical intervention, many
aspects of the anorectic condition are relatively refractory
and some patients continue to have problems for much of
their lives.},
Key = {fds132113}
}
@article{fds131970,
Author = {SM Kealey and JM Provenzale},
Title = {Tensor diffusion imaging in B12 leukoencephalopathy.},
Journal = {Journal of computer assisted tomography, United
States},
Volume = {26},
Number = {6},
Pages = {952-5},
ISSN = {0363-8715},
Keywords = {Cerebral Cortex • Demyelinating Diseases • Female
• Humans • Leukocytes • Magnetic Resonance
Imaging • Middle Aged • Vitamin B 12 Deficiency
• complications* • etiology* • pathology
• pathology*},
Abstract = {Anisotropy measurements were obtained from periventricular
foci of T2 prolongation and adjacent normal-appearing white
matter in a case of B12 leukoencephalopathy. Measurements
were compared with mean values from two age-matched control
subjects. Anisotropy was greatly reduced in the lesions
evident on T2-weighted images and in the normal-appearing
adjacent white matter (WM), indicating that the extent of WM
tract disruption was greater than could be identified on
routine MR sequences.},
Key = {fds131970}
}
@article{fds132178,
Author = {RC Gilkeson and EF Patz and D Culhane and HP McAdams and JM
Provenzale},
Title = {Thoracic imaging features of patients with antiphospholipid
antibodies.},
Journal = {Journal of computer assisted tomography, UNITED
STATES},
Volume = {22},
Number = {2},
Pages = {241-4},
ISSN = {0363-8715},
Keywords = {Adult • Aged • Antibodies, Antiphospholipid •
Antiphospholipid Syndrome • Aorta, Thoracic •
Female • Humans • Magnetic Resonance Imaging
• Male • Middle Aged • Pulmonary Embolism
• Radiography, Thoracic* • Retrospective Studies
• Thrombophlebitis • Thrombosis • Tomography,
X-Ray Computed • blood • complications •
etiology • radiography • radiography*},
Abstract = {PURPOSE: Our aim was to determine the thoracic
manifestations of patients with antiphospholipid antibodies
(APAs). METHOD: We performed a retrospective review of the
clinical records and thoracic imaging studies of 88 patients
(63 women, 25 men; mean age 47 years) with APAs to determine
the spectrum of thoracic disease. RESULTS: Nine patients
(10%) had thoracic abnormalities, including eight with
pulmonary embolism (PE) and one with aortic thrombus. One
patient with PE had subclavian vein thrombosis. Coexistent
thromboses included deep venous thrombosis of the leg in six
patients. CONCLUSION: PE was the most common thoracic
abnormality in our patients. The presence of these
antibodies should be suspected in patients with PE of
otherwise unexplained etiology.},
Key = {fds132178}
}
@article{fds131988,
Author = {JM Provenzale and JP Glass},
Title = {Hemiballismus: CT and MR findings.},
Journal = {Journal of computer assisted tomography, UNITED
STATES},
Volume = {19},
Number = {4},
Pages = {537-40},
ISSN = {0363-8715},
Keywords = {Aged • Brain • Brain Diseases • Humans •
Magnetic Resonance Imaging • Male • Movement
Disorders • Retrospective Studies • Tomography,
X-Ray Computed • complications* • diagnosis*
• etiology* • pathology* •
radiography},
Abstract = {OBJECTIVE: Our aim was to determine the frequency with which
a lesion responsible for hemiballismus was detectable on CT
and MR examinations. MATERIALS AND METHODS: The CT and MR
examinations of six patients with hemiballismus were
reviewed. Three patients underwent MRI alone, two CT alone,
and one underwent both CT and MRI. Sites considered as
possible locations for a lesion causing hemiballismus
included the subthalamic nucleus on the side contralateral
to the movements, contralateral putamen, caudate nucleus,
thalamus, corpus striatum, lenticular nucleus, substantia
nigra, and the premotor and motor cortex. RESULTS: A lesion
likely to account for hemiballismus was found in five
patients (contralateral subthalamic nucleus in four
patients, contralateral putamen in one patient). Causes of
hemiballismus included infarction (one patient), hemorrhage
(two patients), trauma (one patient), and an abscess (one
patient). A responsible lesion was detected in all five
patients who underwent MRI. In one patient who underwent CT
alone, a responsible lesion was not identified. CONCLUSION:
A lesion responsible for hemiballistic movements can
generally be found on cross-sectional imaging examinations.
Because the multiplanar imaging capability of MR appears to
allow for sensitive detection of even small lesions in sites
likely to cause hemiballismus, MRI offers the best means of
imaging these patients.},
Key = {fds131988}
}
@article{fds132134,
Author = {JM Provenzale and HA Loganbill},
Title = {Dural sinus thrombosis and venous infarction associated with
antiphospholipid antibodies: MR findings.},
Journal = {Journal of computer assisted tomography, UNITED
STATES},
Volume = {18},
Number = {5},
Pages = {719-23},
ISSN = {0363-8715},
Keywords = {Adult • Antibodies, Antiphospholipid • Cerebral
Hemorrhage • Cerebral Infarction • Cerebral Veins
• Dura Mater • Humans • Lupus Coagulation
Inhibitor • Magnetic Resonance Imaging* • Male
• Middle Aged • Sinus Thrombosis, Intracranial
• analysis • analysis* • diagnosis* •
immunology • pathology*},
Abstract = {OBJECTIVE: Our goal was to describe the neuroradiologic
findings in hemorrhagic venous infarction related to a
hypercoagulable state caused by antiphospholipid antibodies
(aPA). MATERIALS AND METHODS: Magnetic resonance imaging was
performed on two patients with superior sagittal thrombosis
related to the presence of aPA. RESULTS: A parenchymal
region of hyperintense signal due to hemorrhagic venous
infarction was demonstrated in both patients, along with
abnormal signal within the thrombosed superior sagittal
sinus. CONCLUSION: Hemorrhagic venous infarction may result
from the hypercoagulable state related to aPA. The presence
of these antibodies should be considered in the setting of
otherwise unexplained dural sinus thrombosis and/or venous
infarction.},
Key = {fds132134}
}
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