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| Publications of Myron L. Wolbarsht :chronological alphabetical combined listing:%% Journal Articles @article{fds254730, Author = {Decruz, A and wolbarsht, ML and Andreotti, A and Colombini, MP and Pinna, D and Culberson, CF}, Title = {Investigation of the Er:YAG laser at 2.94 μm to remove lichens growing on stone}, Journal = {Studies in Conservation}, Volume = {54}, Number = {4}, Pages = {268-277}, Year = {2009}, ISSN = {0039-3630}, Abstract = {The analysis of the surface ablation of the removal of lichens from stone by use of a free-running pulsed Er:YAG laser (erbium-doped yttrium, aluminium, garnet crystal) at a wavelength of 2.94 μm demonstrated the complete destruction of the lichen cell wall. In this paper these results are confirmed, and experiments are described which seek to determine the physical/ chemical mechanism of the ablation process using pyrolysis gas chromatography-mass spectrometry (pyrolysis GC-MS), highperformance liquid chromatography (HPLC), Fourier transform infrared spectroscopy (FTIR) and fluorescence microscopy.}, Key = {fds254730} } @article{fds254729, Author = {Stefansson, E and III, MBL and Wolbarsht, M}, Title = {Retinal vessel caliber and diabetic retinopathy [3]}, Journal = {Archives of Ophthalmology}, Volume = {123}, Number = {5}, Pages = {709-}, Year = {2005}, Key = {fds254729} } @article{fds254728, Author = {Bracco, P and Lanterna, G and Matteini, M and Nakahara, K and Sartiani, O and Cruz, AD and Wolbarsht, ML and Adamkiewicz, E and Colombini, MP}, Title = {Er:YAG laser: An innovative tool for controlled cleaning of old paintings: Testing and evaluation}, Journal = {Journal of Cultural Heritage}, Volume = {4}, Number = {SUPPL. 1}, Pages = {202s-208s}, Year = {2003}, url = {http://dx.doi.org/10.1016/S1296-2074(02)01232-3}, Abstract = {A cleaning method based on an Er:YAG laser system at 2.94 μm, highly absorbed by OH bonds, was tested for removal of over-paintings, varnishes and patina top-layers from various painted surfaces, including laboratory paint models and old paintings. The aim was to evaluate the efficiency, selectivity and safety of the laser cleaning method using various pulse energies and various OH containing wetting agents to enhance the efficacy and limit the penetration of the laser beam. A large number of paint models were prepared with known characteristics (type and number of layers, thickness, composition) simulating old masters' techniques. A set of diagnostic controls was designed to study the effects of the laser radiation on the surface components, including morphological, optical and chemical examination and analyses. The aim was also to compare the laser method with the traditional solvent based procedures. Thresholds of safe energy were found for each type of surface layer such as varnishes and over-paintings. The results confirmed the suitability of the Er:YAG laser when used by qualified and expert conservators, especially in combination with traditional chemical and mechanical cleaning methods. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.}, Doi = {10.1016/S1296-2074(02)01232-3}, Key = {fds254728} } @article{fds254727, Author = {Cruz, AD and Wolbarsht, ML and Hauger, SA}, Title = {Laser removal of contaminants from painted surfaces}, Journal = {Journal of Cultural Heritage}, Volume = {1}, Number = {2}, Pages = {S173-S180}, Year = {2000}, url = {http://dx.doi.org/10.1016/S1296-2074(00)00182-5}, Abstract = {An analysis of surface ablation by laser exposure of art objects as part of the conservation process indicates that heat diffusion from the site of laser exposure may be minimized by proper selection of wavelength and exposure duration. A model for unwanted material removal with a laser has been developed taking account of the threshold phenomenon of ablation as a function of wavelength, and exposures at 2.94 μm by an Er:YAG laser with short duration pulses is compared with those from a Nd:YAG (1 064 and 532 nm), CO2 (10.6 μm) and the ultraviolet excimer laser at 193 nm. Thermal diffusion is minimized by taking advantage of the large amount of heat removed by the phase change of water into steam. This model suggests that for bulk removal at strongly absorbed wavelengths, many short pulses are better than continuous exposures. The selection of the Er:YAG laser allows the use of hollow glass waveguides of high flexibility, which are commercially available, as delivery systems. Examples of successful removal are given for contaminants overlying a Madonna's gold leaf halo and the heavy dark accumulation of soot on an unvarnished oil painting, as well as for thick synthetic adhesive on canvas. © 2000 Éditions scientifiques et médicales Elsevier SAS.}, Doi = {10.1016/S1296-2074(00)00182-5}, Key = {fds254727} } @article{fds254725, Author = {Wolbarsht, ML and Urbach, F}, Title = {The Lancer Ethnicity Scale.}, Journal = {Lasers in Surgery and Medicine}, Volume = {25}, Number = {2}, Pages = {105-106}, Year = {1999}, Month = {January}, ISSN = {0196-8092}, url = {http://dx.doi.org/10.1002/(sici)1096-9101(1999)25:2<105::aid-lsm1>3.0.co;2-e}, Doi = {10.1002/(sici)1096-9101(1999)25:2<105::aid-lsm1>3.0.co;2-e}, Key = {fds254725} } @article{fds254726, Author = {Cruz, AD and Hauger, SA and Wolbarsht, ML}, Title = {The role of lasers}, Journal = {Optics and Photonics News}, Volume = {10}, Number = {7}, Pages = {36-40}, Year = {1999}, ISSN = {1047-6938}, Key = {fds254726} } @article{fds254720, Author = {Wolbarsht, ML and Landers, MB}, Title = {Diagnosis of the acute red eye.}, Journal = {Journal of the Royal Society of Medicine}, Volume = {91}, Number = {10}, Pages = {560}, Year = {1998}, Month = {October}, ISSN = {0141-0768}, url = {http://www.ncbi.nlm.nih.gov/pubmed/10070388}, Key = {fds254720} } @article{fds254721, Author = {Wolbarsht, ML}, Title = {Correction: Diagnosis of the acute red eye (Journal of the Royal Society of Medicine (1998) October (560))}, Journal = {Journal of the Royal Society of Medicine}, Volume = {91}, Number = {12}, Pages = {662-}, Year = {1998}, Key = {fds254721} } @article{fds254722, Author = {Wolbarsht, ML}, Title = {Thermal and nonthermal mechanisms in the removal of port-wine stains}, Journal = {Laser Physics}, Volume = {8}, Number = {3}, Pages = {782-784}, Year = {1998}, Abstract = {Laser exposure thermal models for the destruction of the skin blood vessels in port-wine stains will be compared to a model in which the unwanted vessels are removed by laser-generated oxygen-free radicals. Theoretical aspects and clinical results for the new model will be presented showing its clinical advantages. Copyright © 1998 by MANK Hayκa/Interperiodica Publishing.}, Key = {fds254722} } @article{fds254723, Author = {Weinbaum, A and Hathcock, G and Whalen, T and Wolbarsht, M}, Title = {Here's how to prevent laser fires in the OR.}, Journal = {Health facilities management}, Volume = {11}, Number = {9}, Pages = {28-30}, Year = {1998}, ISSN = {0899-6210}, Key = {fds254723} } @article{fds254724, Author = {Wolbarsht, ML}, Title = {Survey of bioeffects data and format of standard exposure boundaries}, Journal = {Journal of laser applications}, Volume = {10}, Number = {3}, Pages = {106-108}, Year = {1998}, ISSN = {1042-346X}, Abstract = {As increasingly more applications of lasers are formulated, the gaps in our quantitative data base of biological data are highlighted. In the past, just as now, research is tied to the need for safety data for specific applications. All too often in the past ambiguity or large disjunctions in the expression of the safety limits were ignored because "nobody uses a laser here anyway." Such a cavalier attitude is rarely possible anymore as lasers are at all wavelengths and pulse durations, even as in the ultrashort pulse range where only guidelines have been offered to data due to lack of quantitative experimental information. As the gaps in our information are filled, another problem arises. The original formulation of the safety limits was intended more as a backup for the classification scheme, and there were only a few lasers to classify. As only a relatively few experts used the safety boundary equations either to classify new lasers or to deal with applications not easily covered by standard classification schemes, the mathematical formulations of the boundary conditions were not clearly stated and required cumbersome calculations and references to several tables before any correct answer could be determined. The next revision of the American Conference of Governmental Industrial Hygienists and ANSI documents will embody some changes intended to simplify the calculations and make them more rational. Some examples are the use of dimensionally correct equations and decimal exponents. © 1998 Laser Institute of America.}, Key = {fds254724} } @article{fds254719, Author = {Lockhead, G and Dragoi, V and Wolbarsht, ML}, Title = {The micfogenesis of geometrical illusions: contextdependent changes in visiual sensitivity and the muller-lyer effect}, Journal = {Investigative Ophthalmology & Visual Science}, Volume = {38}, Number = {4}, Pages = {S643}, Year = {1997}, ISSN = {0146-0404}, Abstract = {Purpose, We analyze the influence of visual contexts which resemble the Muller-Lyer configuration on the detectability of a target stimulus. Methods. Six adult subjects were instructed to detect the occurrence of a target while the target and the context were briefly flashed periodically. During each trial the target was presented alone, in conjunction with the context, or neither target nor context were presented. The target occurred randomly at one of four contrasts; the context (outward or inward arrowhead) was always presented at high contrast. We measured the detection ratio (denned as proportion correct detections) for all four target contrasts in the following conditions: (a) target alone; (b) target and outward arrowhead; (c) target and inward arrowhead. We varied the angle between the arrowhead fins and the distance between the arrowhead and the target. Results. Target detection is facilitated by the inward arrowhead and suppressed by the outward arrowhead. The amount of facilitation and suppression increases monotonically with the decrease in arrowhead angie, but it diminishes as target contrast increases. When the distance between target and context increases, both inhibitory and excitatory effects diminish drastically in strength. If distance is further increased the influence of the outward arrowhead changes from suppression to facilitation. The inhibitory and excitatory effects are amplified if a symmetric arrowhead is added on the other end of the target. All observed variations in detection ratio match qualitatively the lesults obtained with the Mulier-Lyer illusion, in which a bar appears long or short when it is flanked by inward or outward arrowheads. Conclusions, (a) Previous results (e.g., Kapadia et al., 1995; Polat and Sagi, 1994) reported facilitory effects of the surround. We found that as a function of surround orientation and spatial offset there is a continuum of surround modulations ranging from strong inhibition to strong excitation; (b) Our findings are consistent with short and long-range receptive field interactions in primary visual cortex and suggest a physiological basis for surround modulation; (c) The Muller-Lyer extent illlusion is correlated with target detectability. We suggest that detectability and perceived extent are caused by the same mechanism.}, Key = {fds254719} } @article{fds254718, Author = {Wolbarsht, ML}, Title = {Permanent blindness from laser exposures in laboratory and industrial accidents}, Journal = {Smart Structures and Materials 2005: Active Materials: Behavior and Mechanics}, Volume = {2674}, Pages = {21-24}, Year = {1996}, ISSN = {0277-786X}, Abstract = {Legal entanglements prevent publication of details on most laboratory and industrial laser accidents in the USA. Many macular injuries involving the fovea show no signs of recovery after several years. Both single eye (usually the dominant one) and binocular exposures are found usually resulting in large deficits in visual performance. The primary lesion is rarely, if ever, centered in the fovea, but is eccentric, superior and nasal and in the parafoveal zone. Accidental laser exposures below the damage threshold are sometimes falsely implicated causally in pre-existing retinal pathology, the grandmother syndrome. Another source of confusion is malingering, either hysterical or purposeful. One test for macular function has been designed to detect malingering, the flash Amsler grid. Functional loss has not been seen without retinal pathology that is easily visible with an ophthalmoscope. The circumstances of almost all accidents resulting in permanent damage are similar and involve Q-switched Nd:YAG lasers at 1,064 nm with the exposure individual staring directly at something in the beam path on purpose. The injurious exposure to the beam occurs by reflection or through an improperly used attenuator. Almost all were foreseeable by well established hazard analysis techniques and preventable by standard laser safety programs or conventional engineering controls.}, Key = {fds254718} } @article{fds254716, Author = {Hoke, JA and Jr, EJB and Gomes, ED and Hooper, BA and Wolbarsht, ML}, Title = {The effect of free electron laser exposure on tooth structure}, Journal = {Lasers in the Life Sciences}, Volume = {6}, Number = {4}, Pages = {251-257}, Year = {1995}, Key = {fds254716} } @article{fds254714, Author = {Xu, J and Wolbarsht, ML}, Title = {Laser injury in China}, Journal = {Lasers in the Life Sciences}, Volume = {6}, Number = {3}, Pages = {181-185}, Year = {1994}, Key = {fds254714} } @article{fds254715, Author = {Wolbarsht, ML}, Title = {Low-level laser therapy (LLLT) and safety considerations}, Journal = {Journal of Laser Applications}, Volume = {6}, Number = {3}, Pages = {170-172}, Year = {1994}, Abstract = {Although the low-power HeNe lasers and diode lasers used for low-level laser therapy (LLLT) and photoactivation of biological processes are usually thought to be 'safe', the possibility that such lasers can cause biological effects raises the question of whether such laser action may, under some conditions, be adverse and thus be unsafe. Some research data can be interpreted as evidence for adverse effects. Laser safety standards classify all CW HeNe lasers with an output power below 1 mW as 'Class 2,' as they are not considered a realistic hazard, whereas most HeNe lasers with an output power between 1 and 15 mW are Class 3A or 3B. Most diode lasers used for LLLT are considered Class 3B. Safety control measures for ocular hazards are expected for Class 3A and 3B laser exposures, but any adverse effects of LLLT will result from long-duration, high-level doses to parts other than the eyes. The hazards will be systemic rather than ocular, and, thus, need evaluation. The safety implications of current knowledge regarding LLLT are discussed with regard to the demonstrated effects in cell cultures, and on vitamin D synthesis is regard to calcium metabolism in adults.}, Key = {fds254715} } @article{fds254717, Author = {Schwarzmaier, H-J and Goldbach, T and Ulrich, F and Schober, R and Kahn, T and Kaufmann, R and Wolbarsht, ML}, Title = {Improved laser applicators for interstitial thermotherapy of brain structures}, Journal = {Proceedings of SPIE - The International Society for Optical Engineering}, Volume = {2132}, Pages = {4-12}, Year = {1994}, Abstract = {Interstitial thermotherapy is a new treatment for deep seated brain tumors. To destroy large tissue volumes without adverse effects (vaporization, carbonization) a new laser catheter was developed. The device combines the radiative heating of distant tissue volumes with the conductive cooling of areas close to the optical fiber tip.}, Key = {fds254717} } @article{fds254713, Author = {Shi, D and Xing, X and Wolbarsht, ML}, Title = {Influence of vibration on microdiameter measurements using a laser-charge-coupled device system.}, Journal = {Applied Optics}, Volume = {32}, Number = {13}, Pages = {2304-2311}, Year = {1993}, Month = {May}, ISSN = {0003-6935}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20820387}, Abstract = {The influence of vibration on dynamic measurements of microdiameters using a laser diffraction-CCD detection system is studied. The theoretical analysis indicates that the influence of vibration on the diffraction pattern of a measured object introduces significant errors into its diameter measurement, and the improvement can be approached by using a TEM(00) Gaussian incident beam instead of the usual uniform beam. The experimental results of these cases are also presented and in good accordance with the theoretical analysis.}, Key = {fds254713} } @article{fds323489, Author = {Wolbarsht, ML and Sliney, DH}, Title = {ANSI Laser Safety Standard Historical Development}, Journal = {Journal of laser applications}, Volume = {4}, Number = {3}, Pages = {18-21}, Year = {1992}, Month = {October}, url = {http://dx.doi.org/10.2351/1.4745311}, Doi = {10.2351/1.4745311}, Key = {fds323489} } @article{fds323490, Author = {Anderberg, B and Bring, OE and Wolbarsht, ML}, Title = {Blinding Laser Weapons and International Humanitarian Law}, Journal = {Journal of Peace Research}, Volume = {29}, Number = {3}, Pages = {287-297}, Year = {1992}, Month = {August}, url = {http://dx.doi.org/10.1177/0022343392029003005}, Doi = {10.1177/0022343392029003005}, Key = {fds323490} } @article{fds323491, Author = {Rockwell, RJ and Marshall, WJ and Wolbarsht, ML and Sliney, DH}, Title = {ANSI Z136.1 Proposed 1992 Changes: An overview of the proposed changes to the American National Standard Z136.1 For The Safe Use of Lasers}, Journal = {Journal of laser applications}, Volume = {4}, Number = {1}, Pages = {45-50}, Year = {1992}, Month = {January}, url = {http://dx.doi.org/10.2351/1.4745298}, Doi = {10.2351/1.4745298}, Key = {fds323491} } @article{fds254710, Author = {Wolbarsht, ML}, Title = {Erratum: Cataract from infrared lasers: Evidence for photochemical mechanisms (Lasers and Light in Ophthalmology, Vol. 4, No. 2, Sept. 1991, pp. 91-96)}, Journal = {Lasers and Light in Ophthalmology}, Volume = {5}, Number = {1}, Pages = {i}, Year = {1992}, Key = {fds254710} } @article{fds254711, Author = {Jr, EJB and Hoke, J and Gomes, E and Wolbarsht, M}, Title = {Wet versus dry enamel ablation by Er:YAG laser}, Journal = {The Journal of Prosthetic Dentistry}, Volume = {67}, Number = {6}, Pages = {847-851}, Year = {1992}, ISSN = {0022-3913}, Abstract = {The purpose of this study was to observe tooth structure and pulpal temperature changes in extracted human teeth subjected to a pulsed Er:YAG (2.94 μm) laser. Two teeth were irradiated while dry and three teeth while moistened by a fine water mist. When the dry teeth were irradiated, there was minimal enamel ablation. SEM of the resulting surface showed rounded fragments of enamel rods, enamel melting, cracks, and smooth-edged voids. Intrapulpal temperature measured by thermal sensor rose more than 27° C. When the laser application on the teeth was pulsed with a constant fine water mist, enamel and dentin were efficiently ablated. SEM of the resulting surfaces showed fissures and conical craters with sharp enamel projections remaining. Intrapulpal temperatures rose an average of 4° C. These results indicate that pulsed Er:YAG (2.94 μm) used with a water mist removes enamel and dentin without producing significant pulpal temperature changes. © 1992 The Editorial Council of The Journal of Prosthetic Dentistry.}, Key = {fds254711} } @article{fds254712, Author = {Schwarzmaier, H-J and Heintzen, MP and Mueller, W and Kaufmann, R and Wolbarsht, ML}, Title = {Changes in optical density of vascular tissue after 308-nm excimer laser irradiation}, Journal = {Proceedings of SPIE - The International Society for Optical Engineering}, Volume = {1642}, Pages = {11-17}, Year = {1992}, Abstract = {Ninety-six transmission spectra were obtained from autopsy specimens of healthy human abdominal aorta. Specimens were irradiated via a 900 μm fused silica fiber (contact mode) under normal saline at room temperature (21.5 ± 1.5°C) using an excimer laser (308 nm, 40 Hz, 115 ns, 57 mJ/mm2). The temperature increased at the fiber tip up to 66.8 ± 8.5°C and was monitored by a NiCrNi thermocouple. Tissue samples from untreated areas and from the thermal damage zone next to the ablation area were anayzed by microspectrophotometry (spectral range 250-800 nm, cryosections 24 μm, area measured 6/3 μ in diameter). The conclusion is, excimer laser irradiation using a high repetition rate in combination with a high output energy changes the optical properties of human vessel walls significantly.}, Key = {fds254712} } @article{fds323492, Author = {Wolbarsht, ML}, Title = {Treating Birthmarks With Diabetes}, Journal = {Journal of laser applications}, Volume = {3}, Number = {3}, Pages = {54-58}, Year = {1991}, Month = {October}, url = {http://dx.doi.org/10.2351/1.4752451}, Doi = {10.2351/1.4752451}, Key = {fds323492} } @article{fds322206, Author = {Lockhead, GR and Wolbarsht, ML}, Title = {Toying with the moon illusion.}, Journal = {Applied Optics}, Volume = {30}, Number = {24}, Pages = {3504-3507}, Year = {1991}, Month = {August}, Abstract = {We propose that the correct interpretation of the moon illusion is that the zenith moon appears small, not that the horizon moon appears large. This illusion is caused by the visual gap between the observer and the overhead moon. Because of the gap, the observer has no or little optical information about the distance of the moon. This results in empty field myopia where the moon is neurally, although not necessarily cognitively, processed as being at about arm's length. When the moon is seen on the horizon, there usually is optical information about distance. That results in reduced accommodation, and so the moon is processed as at a greater distance. Consistent with the size-distance-invariance hypothesis, the moon is then judged as large. This is a specific example of the more general fact that all distant objects appear small in the absence of a stimulus for accommodation to be distant. This outcome produces the toy illusion.}, Key = {fds322206} } @article{fds254705, Author = {Mellerio, J and Marshall, J and Tengroth, B and Anderberg, B and Wolbarsht, M}, Title = {Battlefield laser weapons: An assessment of systems, hazards, injuries and ophthalmic resources required for treatment}, Journal = {Lasers and Light in Ophthalmology}, Volume = {4}, Number = {1}, Pages = {41-67}, Year = {1991}, Abstract = {Many weapon systems now rely on laser generated radiation to perform their designed task. Thousands of these systems have been deployed and most are not eye-safe under battlefield conditions. There is concern that a new battlefield problem - large numbers of blind or severely visually handicapped personnel - could swamp both military and civilian ophthalmic services. Working from unclassified sources, known weapon systems that use lasers are described and classified. The possible effects of battlefield lasers on the eye are discussed, modes of treatment are considered and a scheme for handling laser casualties on the battlefield is proposed. Likely loadings on medical facilities are examined and protection strategies are reviewed.}, Key = {fds254705} } @article{fds254706, Author = {Shi, D and Xing, X and Wolbarsht, ML}, Title = {Holographic filter for coherent radiations}, Journal = {Proceedings of SPIE - The International Society for Optical Engineering}, Volume = {1419}, Pages = {40-49}, Year = {1991}, Abstract = {It is proposed to construct holographic devices which act as optical elements to modify the path of high spatially coherent radiation but not affect incoherent radiation. The device must be composed of a laser-read holographic element in association with a band-pass spatial filter. The holographic filters will be wavelength independent to allow possible action as agile filters for laser safety protection while maintaining sufficient transmission for visual performance.}, Key = {fds254706} } @article{fds254707, Author = {Wolbarsht, ML}, Title = {Cataract from infrared lasers: Evidence for photochemical mechanisms}, Journal = {Lasers and Light in Ophthalmology}, Volume = {4}, Number = {2}, Pages = {91-96}, Year = {1991}, Abstract = {Two theories for cataract formation by IR radiation are reviewed: Goldmann's hypothesis that cataracts result from heat transferred to the lens from the IR absorbed by the iris is contrasted with Vogt's hypothesis in which the IR energy is absorbed directly by the lens. Data show that cataracts can be formed by both mechanisms and that cataracts resulting from long-term exposures are most likely in accordance with Vogt's hypothesis. Data from laser and IR heat lamp exposures to in vivo lenses and incubated whole lenses and various extracted lens crystallins, as well as electrophoresis of lens crystallins on polyacrylamide gels and other types of substrates, show conversion of soluble α and β(H) crystallins into insoluble protein factions with high molecular weight as a result of exposure to broad band heat or narrow band IR laser radiation. Sub-threshold laser exposure levels produce a markedly decreased mobility of the β crystallins in the lens. Reciprocity between exposure power level and duration is obeyed over many orders of magnitude. This constant energy/dose-related requirement for cataract formation suggests major contributions from photochemical rather than thermal mechanisms, while the failure of this relation for longer exposures possibly indicates a partial repair process.}, Key = {fds254707} } @article{fds254708, Author = {Schwarzmaier, H-J and Heintzen, M and Zumdick, M and Kaufmann, R and Wolbarsht, ML}, Title = {Changes in optical density of normal vessel wall and lipid atheromatous plaque after Nd:YAG laser irradiation}, Journal = {Proceedings of SPIE - The International Society for Optical Engineering}, Volume = {1427}, Pages = {128-133}, Year = {1991}, Abstract = {135 transmission spectra were obtained from 26 autopsy specimens of healthy as well as lipid atheromatous human abdominal aorta. The tissue samples were irradiated using a Nd:YAG laser. The optical density of the coagulation zone was significantly increased compared to the untreated areas within all tissue samples over the entire spectral range investigated. In the ultraviolet increases were 2 to 6 fold for intima, 1.2 to 3 fold for media, 2 to 4 fold for adventitia and 1.2 to 2.5 fold for lipid atheromatous plaque respectively. In the visible spectral range increases were 7 to 12 fold for intima, 2 to 5 fold for media, 5 to 9 fold for adventitia and up to 3 fold for lipid atheromatous plaque respectively (data p < 0.001). In addition, differences in the optical density between lipid atheromatous plaque and normal vessel wall decreased after laser irradiation. This indicates that due to the changes of optical properties during laser irradiation data obtained from transmission spectra of the native vessel wall may not be sufficient to predict laser-tissue interaction at least with respect to continuous wave lasers.}, Key = {fds254708} } @article{fds254709, Author = {Wolbarsht, ML and Sliney, DH}, Title = {Historical development of the ANSI laser safety standard}, Journal = {Journal of Laser Applications}, Volume = {3}, Number = {1}, Pages = {5-11}, Year = {1991}, Abstract = {The development of ANSI Z136 standards is traced. The need for a hazard classification is discussed, as are limits for high-power lasers. Changes made to the standard in 1976, 1980, and 1986 are outlined. The concept of the nominal hazard zone is described from the viewpoint of personnel safety.}, Key = {fds254709} } @article{fds254703, Author = {Shi, D and Wolbarsht, ML}, Title = {Transmission of a Gaussian scanning beam through circular, square, and slit apertures: Part I. Theory.}, Journal = {Health Physics}, Volume = {59}, Number = {6}, Pages = {891-899}, Year = {1990}, Month = {December}, ISSN = {0017-9078}, url = {http://www.ncbi.nlm.nih.gov/pubmed/2228616}, Abstract = {Energy and power values for Gaussian profile scanning laser beams through circular, square, and slit apertures may be required for hazard analysis in laser safety programs. Equations describing the transmitted power for a Gaussian beam concentric and eccentric with circular, square, and slit apertures are given. Simple expressions of transmitted power and energy with a scanning laser beam across the square and slit apertures are derived. For the circular aperture, the transmitted power and energy can be calculated conveniently by using the correction factors from the graphic values or from the computer programs.}, Key = {fds254703} } @article{fds254701, Author = {George, GS and Wolbarsht, ML and Landers, MB}, Title = {Reproducible estimation of retinal vessel width by computerized microdensitometry.}, Journal = {International Ophthalmology}, Volume = {14}, Number = {2}, Pages = {89-95}, Year = {1990}, Month = {March}, ISSN = {0165-5701}, url = {http://www.ncbi.nlm.nih.gov/pubmed/2338387}, Abstract = {An objective method for reliably estimating the width of retinal vessels is presented. A computerized microdensitometer scans film negatives of fundus photographs and reconstructs black and white images of the fundus on a visual display terminal. After this initial scan, a desired region of a retinal vessel is selected with moveable cursors, and a cross-sectional density profile through the vessel is plotted. Vessel width is determined by the half-height width of the profile of the minimum (least transmitting) and average background film densities. Measurement sites can be accurately reproduced on different negatives by landmark mapping. A series of ten fundus photographs were taken of three healthy human eyes, and the width of the superior temporal vein was measured in two places on alle negatives. The coefficient of variation of the six sets ranged from 1.2 and 3.4% with an average of 2.2%.}, Key = {fds254701} } @article{fds254699, Author = {Wolbarsht, ML and Sliney, DH}, Title = {Laser medicine.}, Journal = {Current Opinion in Ophthalmology}, Volume = {1}, Number = {1}, Pages = {60-63}, Year = {1990}, Month = {February}, ISSN = {1040-8738}, url = {http://www.ncbi.nlm.nih.gov/pubmed/10149667}, Key = {fds254699} } @article{fds254700, Author = {Fridovich, I and Wolbarsht, ML}, Title = {Letter to the editor}, Journal = {Free Radical Biology and Medicine}, Volume = {8}, Number = {5}, Pages = {488-489}, Year = {1990}, ISSN = {0891-5849}, Key = {fds254700} } @article{fds254702, Author = {Schwarzmaier, H-J and Hennig, T and Betz, P and Kaufmann, R and Wolbarsht, ML}, Title = {Optical density of healthy human arterial vessel wall and atheromatous plaque as a basis for pulsed laser angioplasty}, Journal = {Proceedings of SPIE - The International Society for Optical Engineering}, Volume = {1201}, Pages = {10-14}, Year = {1990}, Abstract = {Transmissions spectra of healthy human arterial vessel wall (intima, media, adventitia), lipid plaque as well as calcified plaque were obtained from 245 autopsy specimens (25 patients) by microspectrophotometry (25 μm sections, wavelength 240 nm -1070 nm). Lipid plaques showed moderately increased optical density over normal tissue in the visible and near infrared spectral range with maximal values in the blue spectral range (440 nm to 530 nm). At these wavelengths, extinction was about a factor of 5 compared to intima, a factor of 3 higher than in media, and a factor of 7 higher with respect to adventitia. Over the whole spectral range investigated, calcified plaque exhibited a significantly higher optical density compared to all layers of normal vessel wall. The maximum differences were found between 300 and 450 nm for intima (6 to 7 fold), between 440 and 1070 for media (3 fold) and above 550 nm for adventitial (10 to 12 fold).}, Key = {fds254702} } @article{fds254704, Author = {Shi, D and Wolbarsht, ML}, Title = {Optical fiber sensor for oxygen with raman scattering sampling}, Journal = {Proceedings of SPIE - The International Society for Optical Engineering}, Volume = {1201}, Pages = {461-468}, Year = {1990}, Abstract = {The Resonance Raman spectra of hemoglobin (Hb) molecules are exclusively due to scattering of the heme group, and the spectrum of a partially oxygenated Hb sample can be employed as a measure of oxygen partial pressure. A optical fiber oxygen sensor based on immobilized Hb is proposed by taking advantage of the Resonance Raman spectra of oxyHb and deoxyHb.}, Key = {fds254704} } @article{fds303816, Author = {Hoke, JA and Burkes, EJ and Gomes, ED and Wolbarsht, ML}, Title = {Erbium:YAG (2.94 mum) laser effects on dental tissues.}, Journal = {Journal of laser applications}, Volume = {2}, Number = {3-4}, Pages = {61-65}, Year = {1990}, ISSN = {1042-346X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/10149088}, Abstract = {Past trials with soft and calcified tissues have demonstrated that long pulse train (2.5 mus) Er:YAG (2.94 mum) laser may be used to ablate tooth structure of human teeth. Determination of physical and thermal damage to surrounding tissue during removal of enamel and dentin is a primary objective of this study. Extracted human teeth with thermal probes imbedded in the pulp chambers were submitted to cavity preparation using an Erbium YAG laser with water mist. Wavelength selection as well as use of a water mist during the procedure resulted in efficient tissue removal without significant surrounding damage. Ground sections and SEM sections of teeth showed little or no melting or ash formation in adjacent dentin and enamel and no visible change in the pulp chamber. The surfaces produced by laser ablation were rough and irregular with craters and grooves. Average temperature change in the pulp chamber monitored during tooth preparation was 2.2 degrees Centigrade. These findings suggest that constantly available water aids vaporization and microexplosions, increasing the efficiency of tooth structure removal, and aids in cooling of the tooth structures. The long pulse Er:YAG (2.94 mum) laser may be an effective method for tooth reduction applications when used with a water mist.}, Key = {fds303816} } @article{fds254694, Author = {Wolbarsht, ML and Welch, AJ}, Title = {Evaluation of ocular protection filters in field situations.}, Journal = {Health Physics}, Volume = {56}, Number = {5}, Pages = {729-739}, Year = {1989}, Month = {May}, ISSN = {0017-9078}, url = {http://www.ncbi.nlm.nih.gov/pubmed/2708062}, Abstract = {A computer program has been developed to simulate eye movement during pursuit tracking to test the effectiveness of filters protecting the eyesight of individuals exposed to laser radiation. Two types of retinal damage are considered: macular lesions and retinal injury causing vitreous or subretinal hemorrhage. The retinal damage caused by optical radiation in the visible and near infrared of the spectrum differs from almost all other types of hazards in their proabilistic nature. That is, a small movement of the laser beam or change of eye position decreases or increases the probability of injury by several orders of magnitude. A laser beam combines the problem of a small source with extreme directionality with the probabilistic nature of this hazard location in space, and we now add the probabilistic nature of the action of the protective filter, i.e., a dependence upon angle of incidence. From this combination, an even more probabilistic picture of injury or disablement emerges. When it is necessary to plan the probabilities during military operations of mission fulfillment or injury with regard to various types of lasers in the battlefield ++environment, the problem must be analyzed very carefully. Our solution of the problem indicates the type of injuries to be expected and their dependence upon the various parameters of the angle of incidence of the lasers on the protective filters in the viewing system.}, Key = {fds254694} } @article{fds254696, Author = {Sliney, DH and Wolbarsht, ML}, Title = {Future applications of lasers in surgery and medicine: a review.}, Journal = {Journal of the Royal Society of Medicine}, Volume = {82}, Number = {5}, Pages = {293-296}, Year = {1989}, Month = {May}, ISSN = {0141-0768}, url = {http://www.ncbi.nlm.nih.gov/pubmed/2666663}, Abstract = {The experimental use of lasers in surgery and medicine began only shortly after the development of the first working laser system. However, the development of practical, effective, and safe surgical lasers has been lengthy with many obstacles and delays. Today the laser is used for a wide variety of surgical operations. The fundamental limits and potential for future applications of lasers in surgery and medicine are discussed.}, Doi = {10.1177/014107688908200516}, Key = {fds254696} } @article{fds254695, Author = {Wolbarsht, ML and Fridovich, I}, Title = {Hyperoxia during reperfusion is a factor in reperfusion injury.}, Journal = {Free Radical Biology and Medicine}, Volume = {6}, Number = {1}, Pages = {61-62}, Year = {1989}, ISSN = {0891-5849}, url = {http://www.ncbi.nlm.nih.gov/pubmed/2536344}, Abstract = {Imposition of ischemia should result in accumulation of lactic acid with an attendant drop in pH. Subsequent reperfusion would result in hyperoxia, in the affected tissue, due to the Bohr Effect. O2- should therefore be produced in greater than normal amounts, due to this transient hyperoxia, and may contribute to reperfusion injury. Tissue acidification, during extreme exercise or in diabetes mellitus, may similarly lead to hyperoxia and to tissue damage by O2-.}, Key = {fds254695} } @article{fds254697, Author = {Goldman, L and Michaelson, SM and Rockwell, RJ and Sliney, DH and Tengroth, BM and Wolbarsht, ML}, Title = {Optical radiation, with particular reference to lasers}, Journal = {World Health Organization Regional Publications - European Series}, Number = {25}, Pages = {49-83}, Year = {1989}, Key = {fds254697} } @article{fds254698, Author = {Schwarzmaier, H-J and Hennig, T and Rettig, B and Kaufmann, R and Wolbarsht, ML}, Title = {Optical properties of calcified atheromatous plaque. Implications for selective laser angioplasty}, Journal = {Advances in Vascular Pathology 1989 vol. 1: proceedings of the 15th world congress of the International Union of Angiology. ICS868}, Pages = {353-358}, Year = {1989}, Key = {fds254698} } @article{fds254692, Author = {Pakalnis, VA and Wolbarsht, ML and Landers, MB}, Title = {Phenylephrine-induced anterior chamber hypoxia.}, Journal = {Annals of ophthalmology}, Volume = {20}, Number = {7}, Pages = {267-270}, Year = {1988}, Month = {July}, ISSN = {0003-4886}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3178082}, Abstract = {The effect of topical phenylephrine 10% solution on anterior chamber oxygen tension (PO2) was studied in cats using an oxygen-sensitive electrode inserted into the midanterior chamber. A decrease in anterior chamber PO2 was usually observed within eight to 25 minutes and declined steadily thereafter. Within two hours, the drug caused a dramatic 60% reduction in anterior chamber oxygen tension (P less than or equal to .0005). We suggest that the mechanism for this phenylephrine-induced anterior chamber hypoxia is reduced blood flow, mediated by the direct vasoconstrictive effect of the drug and compression of the iris vasculature (induced by dilatation). The resulting decrease in the caliber of the iris arteries produced a parallel decrease in blood volume and flow which resulted in diminished PO2. Phenylephrine 10% may contribute to hypoxia and exacerbate the underlying pathology in those disorders where hypoxia plays an important causal role.}, Key = {fds254692} } @article{fds323493, Author = {Shi, DX and Wolbarsht, ML}, Title = {Microscope objectives, cover slips, and spherical aberration: comments.}, Journal = {Applied Optics}, Volume = {27}, Number = {11}, Pages = {2106}, Year = {1988}, Month = {June}, Key = {fds323493} } @article{fds254691, Author = {Ham, WT and Mueller, HA and Wolbarsht, ML and Sliney, DH}, Title = {Evaluation of retinal exposures from repetitively pulsed and scanning lasers.}, Journal = {Health Physics}, Volume = {54}, Number = {3}, Pages = {337-344}, Year = {1988}, Month = {March}, ISSN = {0017-9078}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3346165}, Abstract = {Threshold damage in the macaque retina is shown to be equivalent for the argon-krypton (Ar-Kr) 647 nm and the helium-neon (He-Ne) 632.8-nm lines for exposures to continuous wave (CW) radiation from 1 to 1,000 s. This equivalence allows interpolation from experiments with 647-nm, exposures at power levels that are unavailable with the He-Ne laser. To simulate He-Ne laser scanner exposures, 40-microseconds pulses of 647-nm light transmitted through a revolving disk with holes in the periphery were used to expose the retinas of monkeys under deep anesthesia at pulse repetition frequencies (PRFs) of 100, 200, 400, and 1,600 Hz for exposure durations of 1, 10, 100, and 1,000 s. The thresholds between laser exposure at 488 nm (Ar-Kr) and between laser exposure at 647 nm (Kr) are compared to assess thermal versus photochemical effects on the retina. The threshold for 488-nm pulses was consistently lower than that for 647-nm pulses at all PRFs and exposure times. The difference in thresholds increased with exposure time and PRF. The sharp decreases in 488-nm thresholds at 100-s exposure times for each PRF can be interpreted as a basically photochemical effect. The radiant exposure required for damage at 647 nm was several orders of magnitude above the radiant exposure from typical He-Ne scanner applications. From the similarity of the macaque retina to the human retina, it is concluded that no realistic ocular hazard exists from exposure to scanning laser systems of 1 mW or less, operating at higher than 100 Hz.}, Key = {fds254691} } @article{fds254693, Author = {Goldman, L and Michaelson, SM and Rockwell, RJ and Sliney, DH and Tengroth, BM and Wolbarsht, ML}, Title = {Nonionizing radiation protection. Optical radiation, with particular reference to lasers.}, Journal = {WHO regional publications. European series}, Volume = {25}, Pages = {49-83}, Year = {1988}, ISSN = {0378-2255}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3267261}, Key = {fds254693} } @article{fds254687, Author = {Seaber, JH and Fisher, B and Lockhead, GR and Wolbarsht, ML}, Title = {Incidence and characteristics of McCollough aftereffects following video display terminal use.}, Journal = {Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association}, Volume = {29}, Number = {9}, Pages = {727-729}, Year = {1987}, Month = {September}, ISSN = {0096-1736}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3681504}, Abstract = {After using video display terminals (VDT), some persons notice that achromatic patterns appear faintly colored hours after terminal use. We investigated the incidence of this effect, the McCollough effect (ME), among 125 VDT users. Subjects completed a questionnaire regarding work habits and certain life-style aspects. They were shown photographs of varying spatial frequencies to identify the adapting stimulus responsible for the ME. The incidence of ME after routine use of VDTs was 19.1%. The adapting stimulus was the repeating character lines of the VDT. No aspect of life-style investigated appeared to predispose an individual to develop the ME. Those subjects who developed the ME did not differ from those who did not in age, sleep, caffeine consumption, use of medication, refractive errors, or computer usage, nor did they have a higher incidence of ocular defects or eye strain.}, Key = {fds254687} } @article{fds254690, Author = {Wolbarsht, ML and Sliney, DH and Muc, AM}, Title = {Reply to comments on editorial about radiofrequency standards.}, Journal = {Health Physics}, Volume = {53}, Number = {3}, Pages = {334}, Year = {1987}, Month = {September}, ISSN = {0017-9078}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3623927}, Key = {fds254690} } @article{fds254688, Author = {Pakalnis, VA and Rustgi, AK and Stefansson, E and Wolbarsht, ML and Landers, MB}, Title = {The effect of timolol on anterior-chamber oxygenation.}, Journal = {Annals of ophthalmology}, Volume = {19}, Number = {8}, Pages = {298-300}, Year = {1987}, Month = {August}, ISSN = {0003-4886}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3662313}, Abstract = {The effect of timolol maleate, a nonspecific beta-blocking agent, on anterior-segment oxygenation was studied using oxygen-sensitive microelectrodes inserted into the mid-anterior chamber of 13 cat eyes. The anterior-chamber oxygen tension was monitored continuously for two hours following the topical application of three drops of timolol 0.5%. Although a small, but significant, decline in oxygen tension of 19% was observed over the initial 90 minutes (P less than or equal to .05), the overall 10% decrease at the end of two hours was not considered either clinically or statistically significant when compared with a group of controls. Timolol, since it does not contribute significantly to hypoxia, may therefore be a more prudent choice for lowering intraocular pressure in disorders where hypoxia is believed to play an important role, such as in neovascular glaucoma and sickle-cell hyphema.}, Key = {fds254688} } @article{fds303815, Author = {Sternberg, P and Wolbarsht, ML and Landers, MB and Parel, JM}, Title = {Contact lens filter for macular photocoagulation with monochromatic green argon laser.}, Journal = {Retina (Philadelphia, Pa.)}, Volume = {6}, Number = {3}, Pages = {164-168}, Year = {1987}, Month = {February}, ISSN = {0275-004X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/2432638}, Abstract = {Safer and more effective macular photocoagulation can be performed with monochromatic green light, thereby avoiding the energy absorption by the xanthophyll pigment in the inner retina in the blue portion (488 nm line) of the argon laser radiation. While an appropriate laser filter has been built into commercially available laser systems to provide a "green-only option," a contact lens filter which provides monochromatic green energy with a standard argon laser delivery system has been evaluated. The filter requires twice as much laser energy output from the laser, and may allow higher levels of energy to reflect off the filter towards observers.}, Key = {fds303815} } @article{fds254685, Author = {Wolbarsht, ML and Stefansson, E and Landers, MB}, Title = {Retinal oxygenation from the choroid in hyperoxia.}, Journal = {Experimental Biology}, Volume = {47}, Number = {1}, Pages = {49-52}, Year = {1987}, ISSN = {0176-8638}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3666099}, Abstract = {The extraordinarily high rate of blood flow in the cat choroid allows the choroidal oxygen tension to rise to levels close to the arterial PO2, even with oxygen enriched breathing mixtures. The high PO2 in the choroid can elevate the oxygen tension of the inner retina above the saturation PO2 of hemoglobin when oxygen enriched breathing mixtures at one atmosphere or less are used as shown by polarographic oxygen tension measurements in the preretinal vitreous in cats.}, Key = {fds254685} } @article{fds254689, Author = {Wolbarsht, ML and Sliney, DH}, Title = {LASER SAFETY STANDARDS MOVE ON.}, Journal = {Lasers & applications}, Volume = {6}, Number = {4}, Pages = {96-98}, Year = {1987}, Abstract = {Several important changes have been made in the most recent version (1986) of the American National Standards Institute (ANSI) Standard Z136. 1 Safe Use of Lasers. The development of new biological data, the reassessment of old data, and our on-going familiarity with contemporary laser usage all lead to continual revision of our judgments on laser safety. In formulating the changes that went into the 1986 revision of the Standard, changes in maximum permissible exposure (MPE) values for both eye and skin have been made and have carried over into other sections of the standard. The most notable of the carryovers are in the control measures for Class III and Class IV lasers.}, Key = {fds254689} } @article{fds323494, Author = {WOLBARSHT, ML}, Title = {SPECIAL SECTION - LASER TISSUE INTERACTIONS, ABLATION, AND LONG-TERM EFFECTS - THEORIES AND EXPERIMENTS .1. INTRODUCTION}, Journal = {Lasers in Surgery and Medicine}, Volume = {6}, Number = {6}, Pages = {487-487}, Year = {1987}, url = {http://dx.doi.org/10.1002/lsm.1900060602}, Doi = {10.1002/lsm.1900060602}, Key = {fds323494} } @article{fds323495, Author = {Wolbarsht, ML and Allen, RG}, Title = {New laser device for ophthalmology: comment.}, Journal = {Applied Optics}, Volume = {25}, Number = {10}, Pages = {1533-1534}, Year = {1986}, Month = {May}, Key = {fds323495} } @article{fds254603, Author = {Ringo, JL and Wolbarsht, ML}, Title = {Spectral coding in cat retinal ganglion cell receptive fields.}, Journal = {Journal of Neurophysiology}, Volume = {55}, Number = {2}, Pages = {320-330}, Year = {1986}, Month = {February}, ISSN = {0022-3077}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3950694}, Abstract = {We have examined the spectral-coding properties of ganglion cell receptive fields in the cat retina. Two classes of spectral coding were found. The first class consists of cells in which color opponency is spatially local. That is, the opponent cone types cover the same (center or surround) region of the receptive field. The second class consists of cells that show color opponency only to large stimuli (relative to center diameter). Center and surround regions of cells of this class have different spectral sensitivities. Individually the regions are nonopponent. When both regions are stimulated, a spectral opponency is revealed. For example, we recorded from one unit in which the ON-center was mediated by the 556-nm cone type and the OFF-surround was mediated by both 450- and 556-nm cone types. Large-field, threshold-level stimulation in the short-wavelength end of the spectrum produced OFF-responses, while in the long-wavelength end produced ON-responses. For a small stimulus, cells of the second class could mediate spatial vision, largely unaffected by the chromatic properties of the stimulus. Cells of the second class (center/surround opponent) were more commonly encountered than cells of the first class (locally opponent). Color-opponent units of X, Y, and W types were all found.}, Doi = {10.1152/jn.1986.55.2.320}, Key = {fds254603} } @article{fds254682, Author = {Kylstra, JA and Wierzbicki, T and Wolbarsht, ML and Landers, MB and Stefansson, E}, Title = {The relationship between retinal vessel tortuosity, diameter, and transmural pressure.}, Journal = {Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie}, Volume = {224}, Number = {5}, Pages = {477-480}, Year = {1986}, ISSN = {0721-832X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3758696}, Abstract = {Increases in retinal vein tortuosity are thought to be caused by increases in vascular transmural pressure. We have attempted to determine the relationship between retinal vessel tortuosity, diameter, and transmural pressure by examining the effects of changes in transmural pressure on latex tubes with fixed ends. As the transmural pressure is raised, tube diameter increases, but tortuosity does not begin increasing until a critical pressure is reached. Above the critical pressure, tortuosity increases more rapidly than diameter. Our results support the above hypothesis and also suggest that at high transmural pressures, retinal vessel tortuosity is a more sensitive indicator than is the diameter of changes in retinal venous transmural pressure, but diameter is more sensitive than tortuosity at lower pressures.}, Key = {fds254682} } @article{fds254683, Author = {Wolbarsht, ML and III, MBL}, Title = {VISION TESTS FOR MEDICAL SURVEILLANCE OR TO INSURE JOB FITNESS.}, Journal = {Proceedings of SPIE - The International Society for Optical Engineering}, Volume = {601}, Pages = {121-129}, Year = {1986}, Abstract = {The rationale for designing screening type eye examinations to document visual capabilities for specific jobs or changes in visual function following exposure to specific ocular hazards is discussed. Possible applications to clinical situations are also discussed. Specific tests meeting requirements of definite end point quantification, ease of administration, and reproducibility are given for contrast (glare) sensitivity, distortions in macular imaging (Amsler grid), and color vision. The selection is detailed for the individual test combinations of various populations such as automobile driver license applicants, visual display operators, and persons exposed to lasers, including military as well as non-military installers and repairers of optical fibers for communications.}, Key = {fds254683} } @article{fds254684, Author = {Guenther, KH and Wolbarsht, ML}, Title = {SAFETY EYE PROTECTION FOR FIELD USE OF LASERS.}, Journal = {Proceedings of SPIE - The International Society for Optical Engineering}, Volume = {601}, Pages = {88-100}, Year = {1986}, Abstract = {Based on computer calculations of the irradiance on the eye when laser range finders at wavelengths of 694 nm or 1064 nm are used, safety distances are derived for the worst case of directly looking into the laser source with the unaided eye, as well as with magnifying viewing instruments (binoculars, periscopes). From this, attenuation factors (optical densities) of protective filters for both applications are determined. Various means of attaining the necessary protection are discussed, and it is concluded that dielectric interference filters, sometimes in combination with spectrally absorbing glass substrates, are still the most reliable and economic solution, at least for eye protection through optical instruments. The mass production and widespread use of versatile and efficient goggles for individual personnel protection remains still a problem, particularly when corrective spectacles are included.}, Key = {fds254684} } @article{fds254686, Author = {Pakalnis, VA and Wolbarsht, ML and Landers, MB}, Title = {Ocular oxygenation: the effect of phenylephrine on anterior chamber oxygen tension.}, Journal = {Advances in Experimental Medicine and Biology}, Volume = {200}, Pages = {233-241}, Year = {1986}, ISSN = {0065-2598}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3799311}, Abstract = {Phenylephrine preparations are widely used in medicine for their vasoconstrictive and mydriatic effects. The effect of phenylephrine, a powerful alpha-receptor stimulant, on anterior chamber oxygen tension (Po2) was studied using a polarographic electrode inserted into the mid anterior chamber of cats. A commercial 10% solution was applied topically. A decrease in anterior chamber Po2 was usually observed in 8-24 minutes and declined steadily thereafter. Prior to treatment, the mean anterior chamber Po2 was 26 +/- 3 torr; 1/2 hour after treatment it decreased to 20 +/- 7 torr. After 1 hour it dropped to 13 +/- 8 torr and was further reduced to 11 +/- 6 torr by 2 hours. By 90 minutes, the drug had caused a 58% reduction in anterior chamber oxygen tension. This drop is similar to that reported for epinephrine. It is suggested that the mechanism for most of this decrease is reduced blood flow, mediated by the direct vasoconstrictive effect of the drug in addition to compression of the iris vasculature induced by dilation. The resulting change (reduction) in caliber of the iris arteries produces a parallel change (reduction) in blood volume and flow resulting in a diminished Po2. The clinical implications of this conclusion in disorders where hypoxia is felt to play a causal role such as neovascular glaucoma, diabetes, pregnancy and hyphema in sickle cell disease are explored.}, Key = {fds254686} } @article{fds254681, Author = {Wolbarsht, ML and Landers, MB}, Title = {Testing visual capabilities for medical surveillance or to ensure job fitness.}, Journal = {Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association}, Volume = {27}, Number = {12}, Pages = {897-901}, Year = {1985}, Month = {December}, ISSN = {0096-1736}, url = {http://www.ncbi.nlm.nih.gov/pubmed/4087056}, Abstract = {A rationale is presented for designing screening-type eye examinations to document visual capabilities for specific jobs or changes in visual function following exposure to specific ocular hazards. Possible applications to clinical situations are also discussed. A battery of tests that includes contrast (glare) sensitivity, distortions in macular imaging, and color vision is detailed for use with three populations: automobile driver's license applicants, visual display operators, and laser users, including military as well as nonmilitary installers and repairers of optical fibers for communications.}, Key = {fds254681} } @article{fds254679, Author = {Sliney, DH and Wolbarsht, ML and Muc, AM}, Title = {Differing radiofrequency standards in the microwave region--implications for future research.}, Journal = {Health Physics}, Volume = {49}, Number = {5}, Pages = {677-683}, Year = {1985}, Month = {November}, ISSN = {0017-9078}, url = {http://www.ncbi.nlm.nih.gov/pubmed/4066330}, Key = {fds254679} } @article{fds254680, Author = {Wolbarsht, ML and Lockhead, GR}, Title = {Moon illusion: a new perspective.}, Journal = {Applied Optics}, Volume = {24}, Number = {12}, Pages = {1844}, Year = {1985}, Month = {June}, ISSN = {0003-6935}, url = {http://www.ncbi.nlm.nih.gov/pubmed/18223803}, Key = {fds254680} } @article{fds254678, Author = {Wolbarsht, ML}, Title = {LASER SURGERY: ALTERNATIVES TO CO//2 ABLATION.}, Journal = {Proceedings of SPIE - The International Society for Optical Engineering}, Volume = {540}, Pages = {398-404}, Year = {1985}, Abstract = {Laser surgery may be improved by modifications based on similar processes in industrial applications. A major problem in materials processing is minimizing heat diffusion from the site of laser exposure. The same problem exists in the surgery of tissue with a CO//2 laser. A model is described which indicates that radiation at 2. 9 mu m (HF laser) in short duration pulses, shorter than the thermal relaxation time (1. 7 mu s) of its 2 mu m thick absorption depth in water, will minimize thermal diffusion, and also take advantage of the large amount of heat removed by the phase change of water into steam. This model suggests that, for deep cuts, many short pulses are preferable to a single long duration exposure and that more delicate surgery may be possible with such short pulse, shallow absorption depth types of energy delivery.}, Key = {fds254678} } @article{fds254731, Author = {Stefansson, E and Landers, MB and Wolbarsht, ML and Klintworth, GK}, Title = {Neovascularization of the iris: an experimental model in cats.}, Journal = {Investigative Ophthalmology & Visual Science}, Volume = {25}, Number = {3}, Pages = {361-364}, Year = {1984}, Month = {March}, ISSN = {0146-0404}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6199323}, Abstract = {Neovascularization of the iris was induced in cats by removing the vitreous and lens and creating a rhegmatogenous retinal detachment. The presence of new blood vessels on the anterior surface of the iris was verified from the second month onward by slit lamp examination, as well as by light microscopy six to twelve months after the operation. Control eyes undergoing vitrectomy and lensectomy, but without retinal detachment, did not develop rubeosis iridis. This model may allow investigation into causes and therapy of rubeosis iridis.}, Key = {fds254731} } @article{fds254675, Author = {Jr, PS and III, MBL and Wolbarsht, M}, Title = {The negative coincidence of retinitis pigmentosa and proliferative diabetic retinopathy}, Journal = {American Journal of Ophthalmology}, Volume = {97}, Number = {6}, Pages = {788-789}, Year = {1984}, ISSN = {0002-9394}, Key = {fds254675} } @article{fds254676, Author = {III, MBL and Jr, PS and Wolbarsht, M}, Title = {Reply}, Journal = {American Journal of Ophthalmology}, Volume = {98}, Number = {4}, Pages = {524-}, Year = {1984}, ISSN = {0002-9394}, Key = {fds254676} } @article{fds254677, Author = {Wolbarsht, ML}, Title = {LASER SURGERY: CO//2 OR hf.}, Journal = {IEEE Journal of Quantum Electronics}, Volume = {QE-20}, Number = {12}, Pages = {1427-1432}, Year = {1984}, url = {http://dx.doi.org/10.1109/JQE.1984.1072328}, Abstract = {A model based on vitreous surgery is described which indicates that radiation at 2. 9 mu m (hf laser) in short duration pulses, shorter than the thermal relaxation time (1. 7 mu s) of its 1 mu m thick absorption depth in water, will minimize thermal diffusion, and also take advantage of the large amount of heat removed by the phase change of water into steam. This model suggests that, for deep cuts, many pulses are preferable to a single long duration exposure, and that more delicate surgery may be possible with such short pulse, shallow absorption depth types of energy delivery.}, Doi = {10.1109/JQE.1984.1072328}, Key = {fds254677} } @article{fds254673, Author = {Wolbarsht, ML and George, GS and Shearin, WA and Kylstra, JA and Landers, MB}, Title = {Retinopathy of prematurity: a new look at an old disease.}, Journal = {Ophthalmic Surgery}, Volume = {14}, Number = {11}, Pages = {919-924}, Year = {1983}, Month = {November}, ISSN = {0022-023X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6197686}, Abstract = {The neovascular changes of the retinopathy of prematurity can occur in premature infants in three settings: (1) when high levels of supplemental oxygen are administered, neovascularization usually commences shortly after cessation of oxygen therapy; (2) when supplemental oxygen is given for long periods of time, neovascularization can develop while the infant is still receiving oxygen; and (3) neovascularization can occur without exposure to any supplemental oxygen. We propose a model which can explain the occurrence of the retinopathy of prematurity in all these settings. Our model demonstrates that whenever the retinopathy of prematurity occurs, arterial oxygen levels are inappropriately high in relation to the stage of retinal vessel development, even in premature neonates not given supplemental oxygen. The inhibitory effect of these elevated oxygen tensions upon carbon dioxide removal is indicated as a possible cause of neovascularization by leading to tissue acidosis and vasodilatation.}, Key = {fds254673} } @article{fds254669, Author = {Stefánsson, E and Wolbarsht, ML and Landers, MB}, Title = {In vivo O2 consumption in rhesus monkeys in light and dark.}, Journal = {Experimental Eye Research}, Volume = {37}, Number = {3}, Pages = {251-256}, Year = {1983}, Month = {September}, ISSN = {0014-4835}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6628573}, Abstract = {The rate of oxygen consumption in retinas in vitro has been measured in a great number of species, but in vitro estimates have varied partly because the rate of O2 uptake depends heavily upon the composition of the buffered solution used to maintain the retina. The in vitro experiments on frog retinas show a greater O2 consumption in dark than in light conditions, and indicate marked differences in metabolism between light and dark conditions. A method was developed to estimate retinal oxygen consumption in vivo. We evaluated the oxygen consumption of the in vivo Rhesus monkey retina with an intraocular oxygen microelectrode. The intact monkey retina consumes more oxygen in darkness than in light.}, Key = {fds254669} } @article{fds254668, Author = {Stefansson, E and Wolbarsht, ML and Landers, MB}, Title = {The corneal contact lens and aqueous humor hypoxia in cats.}, Journal = {Investigative Ophthalmology & Visual Science}, Volume = {24}, Number = {8}, Pages = {1052-1054}, Year = {1983}, Month = {August}, ISSN = {0146-0404}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6874269}, Abstract = {The cornea normally receives its oxygen from both the atmosphere and the aqueous humor. When a thick polymethylmethacrylate contact lens is placed on the cat cornea, access of atmospheric oxygen to the cornea is restricted, and the outer part of the cornea becomes hypoxic. This results in an increase in the oxygen flux from the aqueous humor into the cornea, and the oxygen tension in the aqueous humor decreases, as is demonstrated in this study. This increased oxygen flux from the aqueous into the cornea tends to alleviate the hypoxia caused by a corneal contact lens. Thus, the cornea can tolerate a thicker contact lens with less hypoxia than would be expected if only the oxygen supply from the atmosphere were considered.}, Key = {fds254668} } @article{fds254602, Author = {Stefansson, E and Shelton, RA and Landers, MB and Walsh, AW and Wolbarsht, ML}, Title = {Iris arteriolar diameters in hypoxia and hyperoxia: a photographic study in albino guinea pigs.}, Journal = {Investigative Ophthalmology & Visual Science}, Volume = {24}, Number = {6}, Pages = {741-743}, Year = {1983}, Month = {June}, ISSN = {0146-0404}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6853100}, Abstract = {The irides of albino guinea pigs were photographed, and the iris arteriolar diameters were measured with the animal breathing room air, 10% O2/90% N2, or 100% O2. The iris arterioles constrict significantly in hyperoxia and dilate in hypoxia. The average constriction in 100% O2 was 27% +/- 8%, and the average dilatation in 10% oxygen was 34% +/- 20%.}, Key = {fds254602} } @article{fds254674, Author = {Wolbarsht, ML and George, GS and Kylstra, J and Landers, MB and Shearin, WA}, Title = {Speculation on carbon dioxide and retrolental fibroplasia.}, Journal = {Pediatrics}, Volume = {71}, Number = {5}, Pages = {859-860}, Year = {1983}, Month = {May}, ISSN = {0031-4005}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6403919}, Key = {fds254674} } @article{fds254670, Author = {Stefansson, E and Robinson, D and Wolbarsht, ML and Landers, MB and Walsh, A}, Title = {Effect of epinephrine on PO2 in anterior chamber.}, Journal = {Archives of Ophthalmology (Chicago, Ill. : 1960)}, Volume = {101}, Number = {4}, Pages = {636-639}, Year = {1983}, Month = {April}, ISSN = {0003-9950}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6838426}, Abstract = {A polarographic oxygen electrode was inserted through the cornea into the middle of the anterior chamber, and the aqueous humor PO2 was continuously monitored. Epinephrine hydrochloride applied topically to the cornea (1% Epifrin: 0.05 to 0.1 mL) or injected into the anterior chamber (Adrenalin Chloride: 1 mg/mL, 0.05 mL) caused a marked decrease in the anterior chamber PO2. This drop in anterior chamber PO2 was not simply due to mydriasis, since atropine sulfate administered in a similar fashion did not cause a notable drop in anterior chamber PO2, and epinephrine applied to eyes with the pupils previously dilated with atropine still caused the typical drop in anterior chamber PO2. The hypoxic effects of epinephrine were reversed by injection of an alpha-adrenergic blocker, phentolamine mesylate (5 mg/mL, 0.05 mL), into the anterior chamber.}, Key = {fds254670} } @article{fds254667, Author = {Stefansson, E and Landers, MB and Wolbarsht, ML}, Title = {Oxygenation and vasodilatation in relation to diabetic and other proliferative retinopathies.}, Journal = {Ophthalmic Surgery}, Volume = {14}, Number = {3}, Pages = {209-226}, Year = {1983}, Month = {March}, ISSN = {0022-023X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6190118}, Abstract = {The features of proliferative retinopathies are reviewed with reference to the vasodilatation that is a common stage in their pathogenesis. Vasodilatation in the retina is discussed in terms of a model in which vessel wall stretch in the retinal venules leads to leakage and proliferation. The beneficial effects of treatments such as panretinal photocoagulation and vitrectomy on the retinal hemodynamics are shown to agree with the hypothetical model.}, Key = {fds254667} } @article{fds254672, Author = {Landers, MB and Wolbarsht, ML}, Title = {Ocular absorption.}, Journal = {Archives of Ophthalmology (Chicago, Ill. : 1960)}, Volume = {101}, Number = {1}, Pages = {134}, Year = {1983}, Month = {January}, ISSN = {0003-9950}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6849649}, Key = {fds254672} } @article{fds254671, Author = {Amthor, FR and Wolbarsht, ML and Ringo, JL}, Title = {Functional implications of On-Off response variation in frog retinal ganglion cells.}, Journal = {Vision Research}, Volume = {23}, Number = {1}, Pages = {21-32}, Year = {1983}, ISSN = {0042-6989}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6603053}, Abstract = {The variation in the number of spikes in responses of frog retinal ganglion cells has been investigated with correlation and other statistical measures. The On and Off responses produced by the same light flash are either uncorrelated or weakly negatively correlated with each other when their averages are stationary in time. Early parts of the Off response are highly negatively correlated with late parts. A weaker negative correlation exists between the early versus late parts of the On response. A model for response generation is considered in which the On and Off responses are mediated by independent bipolar cell pathways, each with its own sustained and transient amacrine cell inhibition.}, Key = {fds254671} } @article{fds254666, Author = {Wolbarsht, ML and George, GS and Kylstra, J and Landers, MB}, Title = {Does carbon dioxide play a role in retrolental fibroplasia?}, Journal = {Pediatrics}, Volume = {70}, Number = {3}, Pages = {500-501}, Year = {1982}, Month = {September}, ISSN = {0031-4005}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6810303}, Key = {fds254666} } @article{fds254665, Author = {Landers, MB and Stefansson, E and Wolbarsht, ML}, Title = {Panretinal photocoagulation and retinal oxygenation.}, Journal = {Retina (Philadelphia, Pa.)}, Volume = {2}, Number = {3}, Pages = {167-175}, Year = {1982}, Month = {January}, ISSN = {0275-004X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6891097}, Abstract = {Panretinal photocoagulation destroys some of the photoreceptors and thereby reduces the oxygen consumption in the outer retina and allows more O2 to flow from the choroid to the inner retina. Measurements of the preretinal oxygen tension were made in rhesus monkeys that had portions of their retinas photocoagulated. With the animal breathing one atmosphere O2, the oxygen tension over photocoagulated areas of retina was significantly higher than the PO2 over normal, untreated areas of retina. It is proposed that the therapeutic effect of panretinal photocoagulation in diabetic retinopathy lies in the oxygenation of the inner retina from the choroid.}, Key = {fds254665} } @article{fds254663, Author = {Wolbarsht, ML}, Title = {INTERACTIONS BETWEEN MATERIAL PROCESSING AND SURGERY.}, Journal = {LIA (Laser Institute of America)}, Volume = {32}, Pages = {1-5}, Year = {1982}, Abstract = {The present use of laser in surgery may be improved by modifications learned from similar processes in industrial applications. One of the major problems in materials processing is minimizing heat diffusion from the site of laser exposure. The same problem exists in surgical tissue cutting with a CO//2 laser. A proposal is made to use short duration pulses less than the thermal relaxation time of water (one microsecond) to minimize thermal diffusion, and also take advantage of the large heat removed by the phase change in water into steam. An examination of this proposal suggests that many short pulses are preferable to a single long duration exposure to make deep cuts, and that more delicate surgery may be possible with such types of energy delivery. Other types of materials processing situations are related to surgical situations where the desired relative depth of absorption of each of the absorbers present can be selected by use of the proper wavelength and exposure duration.}, Key = {fds254663} } @article{fds254664, Author = {Stefansson, E and Landers, MB and Wolbarsht, ML}, Title = {Vitrectomy, lensectomy, and ocular oxygenation.}, Journal = {Retina (Philadelphia, Pa.)}, Volume = {2}, Number = {3}, Pages = {159-166}, Year = {1982}, ISSN = {0275-004X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7178687}, Abstract = {The effect of vitrectomy and lensectomy upon the anterior chamber oxygen tension of the cat eye was measured polarographically. After vitrectomy and lensectomy alone, a reduction of 12 mm Hg (35%) was observed and when retinal veins were also partially occluded, a reduction of 17 mm Hg (50%) was measured as compared with the normal oxygen tension (PO2) of 34 mm Hg. If vitrectomy and lensectomy allow aqueous to deliver oxygen from the anterior part of the eye to the retina, the poorer oxygenation of the iris and the improved oxygenation of the retina might explain both the development of rubeosis iridis and stabilization of proliferative diabetic retinopathy so commonly seen following vitrectomy.}, Key = {fds254664} } @article{fds323496, Author = {Wolbarsht, ML and Walsh, AW and George, G}, Title = {Melanin, a unique biological absorber.}, Journal = {Applied Optics}, Volume = {20}, Number = {13}, Pages = {2184-2186}, Year = {1981}, Month = {July}, Key = {fds323496} } @article{fds254658, Author = {Landers, MB and Stefánsson, E and Wolbarsht, ML}, Title = {The optics of vitreous surgery.}, Journal = {American Journal of Ophthalmology}, Volume = {91}, Number = {5}, Pages = {611-614}, Year = {1981}, Month = {May}, ISSN = {0002-9394}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7234943}, Abstract = {We calculated the refractive power of the human eye in the various optical configurations that may occur during vitreous surgery. We found that a biconcave corneal contact lens with an anterior surface refractive power of -63 to -98 diopters allowed the fundus to be seen when the vitreous cavity was filled with air, as did a weak minus lens attached to the bottom of the operating microscope. Our tests showed that the unsymmetrical biconcave lenses were superior.}, Key = {fds254658} } @article{fds254659, Author = {Wolbarsht, ML and Landers, MB and Stefansson, E}, Title = {Vasodilation and the etiology of diabetic retinopathy: a new model.}, Journal = {Ophthalmic Surgery}, Volume = {12}, Number = {2}, Pages = {104-107}, Year = {1981}, Month = {February}, ISSN = {0022-023X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6164030}, Abstract = {The evidence in support of the theory that retinal vascular stretching leads to leakage, formation of microaneurysms, and neovascularization is reviewed. The efficacy of photocoagulation and vitrectomy in controlling retinal microangiopathy accompanying diabetes is shown to depend upon reduction of the vascular dilatation. It is possible that the vascular dilatation in diabetes results from high blood glucose levels increasing oxygen consumption in the inner retina, with a resulting vascular dilatation to supply increased oxygen to the retina. This retinal vascular dilatation is the initial cause of the vascular pathology in diabetes.}, Key = {fds254659} } @article{fds254597, Author = {Wolbarsht, ML}, Title = {PROPOSAL TO LOCALIZE AN INTRAOCULAR MELANOMA BY PHOTOACOUSTIC SPECTROSCOPY.}, Journal = {Soviet journal of quantum electronics}, Volume = {11}, Number = {12}, Pages = {1623-1624}, Year = {1981}, Month = {January}, ISSN = {0049-1748}, Abstract = {A method of laser-induced photoacoustic spectroscopic imaging (LIPASI) and its possible applications in biological research are described. Possible applications of this method include diagnosis of an intraocular malignant melanoma and cardial infarcts. A comparison is made between LIPASI and the normal ultrasonic imaging technique and the advantages of LIPASI are stressed.}, Key = {fds254597} } @article{fds254660, Author = {Whipple, TL and Wolbarsht, ML and Hickingbotham, DW and Fondren, F}, Title = {Arthroscopic surgery: simple devices to facilitate multiple entries and manipulations of the knee.}, Journal = {Clinical Orthopaedics and Related Research®}, Number = {154}, Pages = {331-335}, Year = {1981}, Month = {January}, ISSN = {0009-921X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7471579}, Abstract = {A system has been especially designed and fabricated for use with an arthroscope and other instruments so that an open passage is maintained through the skin, retinaculum, and joint capsule to allow the insertion and withdrawal of instruments at will. This system is designed to minimize loss of irrigating fluid from the joint during use, including instrument exchanges. A companion stabilization device has been constructed to allow the unassisted application of valgus or varus stress to the knee while leaving the surgeon's hands free.}, Key = {fds254660} } @article{fds254661, Author = {Stefansson, E and Landers, MB and Wolbarsht, ML}, Title = {Increased retinal oxygen supply following pan-retinal photocoagulation and vitrectomy and lensectomy.}, Journal = {Transactions of the American Ophthalmological Society}, Volume = {79}, Pages = {307-334}, Year = {1981}, ISSN = {0065-9533}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7200671}, Abstract = {Panretinal photocoagulation as well as vitrectomy are the main treatment modalities for diabetic and other proliferative retinopathies. We show that both treatments introduce a new source of oxygen to the inner retina and propose that their efficacy in controlling the retinopathy results from their effect on the oxygenation of the inner retina. Panretinal photocoagulation reduces the oxygen consumption of the outer retina and allows more oxygen to diffuse to the inner retina from the choroid. Vitrectomy/lensectomy on the other hand allows aqueous humor to flow back to the retina and give oxygen to the inner retina which normally has a lower PO2 than aqueous humor. This causes the PO2 in aqueous humor to fall.}, Key = {fds254661} } @article{fds254662, Author = {Urbach, F and Wolbarsht, ML}, Title = {OCCUPATIONAL SKIN HAZARDS FROM ULTRAVIOLET (UV) EXPOSURES.}, Journal = {Proceedings of SPIE - The International Society for Optical Engineering}, Volume = {279}, Pages = {201-215}, Year = {1981}, Key = {fds254662} } @article{fds254652, Author = {Crocker, RA and Ringo, J and Wolbarsht, ML and Wagner, HG}, Title = {Cone contributions to cat retinal ganglion cell receptive fields.}, Journal = {The Journal of General Physiology}, Volume = {76}, Number = {6}, Pages = {763-785}, Year = {1980}, Month = {December}, ISSN = {0022-1295}, url = {http://www.ncbi.nlm.nih.gov/pubmed/10822503}, Abstract = {Extracellular microelectrode recordings were made from ganglion cells of the intact, in situ eyes of adult common domestic cats. Three different photopic systems, with peak spectral sensitivities at 450, 500, and 556 nm, were observed. All ganglion cells received input from a cone system with a peak spectral sensitivity of 556 nm. The blue-sensitive cone system was observed in about one-half of the ganglion cells studied. In each case the 450-nm cone system contributed to only one functional type of response, either ON or OFF, in the same cell. The other two photopic systems most often contributed to both the ON and OFF responses of an individual ganglion cell. In four cases the 450-nm cone system mediated responses that were opponent to those of the other two photopic systems. The third photopic mechanism has a peak spectral sensitivity at 500 nm and contributed to most receptive field surrounds and many receptive field centers. It is distinguished from the rod system by the occurrence of a break in both dark-adaptation curves and increment-sensitivity curves. No apparent differences in receptive field cone contributions between brisk-sustained and brisk-transient cells were seen.}, Key = {fds254652} } @article{fds254657, Author = {Wolbarsht, ML and Wortman, J and Schwartz, B and Cook, D}, Title = {A scleral buckle pressure gauge for continuous monitoring of intraocular pressure.}, Journal = {International Ophthalmology}, Volume = {3}, Number = {1}, Pages = {11-17}, Year = {1980}, Month = {December}, ISSN = {0165-5701}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7194323}, Abstract = {An implantable variable resistance pressure gauge has been constructed from a conductive elastomere in the form of a scleral buckle which is suitable for recording intraocular pressure in vivo continuously over an indefinite period of time. The similarity of the pressure transducer to the standard scleral buckles used to reduce retinal detachments suggests that it will be tolerated over a period of years without significant effect on intraocular pressure. The electrical output from these pressure gauges appears to be both well defined and of sufficient magnitude to operate a valve to control intraocular pressure.}, Key = {fds254657} } @article{fds254654, Author = {Wolbarsht, ML and O'foghludha, FA and Sliney, DH and Guy, AW and Smith, AA and Johnson, GA}, Title = {Electromagnetic emission from visual display units: A non-hazard}, Journal = {Smart Structures and Materials 2005: Active Materials: Behavior and Mechanics}, Volume = {229}, Pages = {187-195}, Year = {1980}, Month = {October}, url = {http://dx.doi.org/10.1117/12.958802}, Abstract = {An analysis of the electromagnetic emissions of an IBM Model 32772 visual display unit showed no hazardous levels in any portion of the spectrum. The actual level of emission was measured throughout the spectrum from low frequency radio waves through x-radiation, extending from 10 KHz through 10 GHz, then 0.2 to 10 μm, and from 5 to over 40 keV. In many parts of the spectrum, the level of emission was below the sensitivity of available instrumentation. In the radio frequency range, including the microwave region, measurements were also made on black and white and color television sets for the purpose of comparison. © 1980, SPIE.}, Doi = {10.1117/12.958802}, Key = {fds254654} } @article{fds254656, Author = {Wolbarsht, ML}, Title = {Workshop on ocular safety and eye care.}, Journal = {Investigative Ophthalmology & Visual Science}, Volume = {19}, Number = {9}, Pages = {1124}, Year = {1980}, Month = {September}, ISSN = {0146-0404}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7410005}, Key = {fds254656} } @article{fds254651, Author = {Wolbarsht, ML and Landers, MB}, Title = {The rationale of photocoagulation therapy for proliferative diabetic retinopathy: a review and a model.}, Journal = {Ophthalmic Surgery}, Volume = {11}, Number = {4}, Pages = {235-245}, Year = {1980}, Month = {April}, ISSN = {0022-023X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6155650}, Abstract = {A model is proposed for initiation and inhibition of growth in retinal vessels including the control of proliferative diabetic retinopathy by photocoagulation. The model assumes that chronic dilatation (constriction) of a retinal blood vessel causes (inhibits) growth. Destruction of rods and cones by photocoagulation allows more choroidal oxygen to reach the inner retina and constrict retinal vessels. The attenuated vessels in late stage retinitis pigmentosa are an analogous and exaggerated effect to that from photocoagulation. The control of proliferative diabetic retinopathy is compared to the cause of retrolental fibroplasma. Following vitrectomy the retina utilizes oxygen from the aqueous which results in dilatation of iris vessels followed by rubeosis iridis. From this model, neovascularization from the disc or angle vessels follows the dilatation resulting from increased flow in their distal vascular beds.}, Key = {fds254651} } @article{fds254653, Author = {Urbach, F and Wolbarsht, ML}, Title = {OCCUPATIONAL SKIN HAZARDS FROM ULTRAVIOLET (UV) EXPOSURES.}, Journal = {Proceedings of the Society of Photo-Optical Instrumentation Engineers}, Volume = {229}, Pages = {21-35}, Year = {1980}, Abstract = {The various types of UV effects on the skin are classified according to the part of the spectrum and their beneficial or deleterious nature. Some hazardous ultraviolet sources used in industrial processes are described, and examples of photoallergy, phototoxicity, and photosensitization resulting from UV exposures are given. The incidence of skin cancer as a function of geographical location and exposure to sunlight is discussed in relation natural and artificial exposures to long and short wavelength UV, especially in connection with tanning booths. The conclusion is reached that there is enough ultraviolet in a normal environment to propose a hazard, and additional ultraviolet exposure from industrial or consumer sources is not necessary, and should be eliminated wherever possible.}, Key = {fds254653} } @article{fds254655, Author = {Wolbarsht, ML}, Title = {DAMAGE TO THE LENS FROM INFRARED.}, Journal = {Proceedings of the Society of Photo-Optical Instrumentation Engineers}, Volume = {229}, Pages = {121-142}, Year = {1980}, url = {http://dx.doi.org/10.1117/12.958797}, Abstract = {Cataracts resulting from IR exposure are compared with those linked to UV exposure. The IR exposure produces changes in the lens proteins, the crystallins, while UV exposure seems to attack specific amino acids. Gel electrophoresis of lens proteins have been used to detect the earliest changes possible in cataract formation following exposure to IR from broadband and laser source irradiation. Cataracts can be easily formed in rabbit lenses in vivo when the laser radiation is restricted to the lens alone at power levels above 1 w for 1 min. Lower levels do not produce immediate cataracts but changes in lens proteins can be detected by thin layer isoelectric electrophoresis of plain polyacrylamide gels and with sodium dodecyl sulfate (SDS) or 6 m urea. The plain gels (pH 3. 5 to 10) showed a decrease in the alpha crystallines indicating a possible change of soluble alpha crystallin to an insoluble high molecular (HM) weight form. However, small amounts of beta and gamma crystallins may also be involved in the formation of a HM insoluble aggregate. Soluble HM weight crystallins often were detected as the alpha crystallin disappeared. This HM soluble fraction may be an intermediate step in the process in forming insoluble alpha crystallin.}, Doi = {10.1117/12.958797}, Key = {fds254655} } @article{fds254650, Author = {Coleman, J and Sydnor, CF and Wolbarsht, ML and Bessler, M}, Title = {Abnormal visual pathways in human albinos studied with visually evoked potentials.}, Journal = {Experimental Neurology}, Volume = {65}, Number = {3}, Pages = {667-679}, Year = {1979}, Month = {September}, ISSN = {0014-4886}, url = {http://www.ncbi.nlm.nih.gov/pubmed/467566}, Key = {fds254650} } @article{fds254648, Author = {Johnson, LW and Wolbarsht, ML}, Title = {Mercury poisoning: a probable cause of Isaac Newton's physical and mental ills.}, Journal = {Notes & Records of the Royal Society}, Volume = {34}, Number = {1}, Pages = {1-9}, Year = {1979}, Month = {July}, ISSN = {0035-9149}, url = {http://www.ncbi.nlm.nih.gov/pubmed/11610639}, Key = {fds254648} } @article{fds254649, Author = {Wolbarsht, ML and Landers Iii and MB}, Title = {Lasers in ophthalmology: the path from theory to application.}, Journal = {Applied Optics}, Volume = {18}, Number = {10}, Pages = {1518-1526}, Year = {1979}, Month = {May}, ISSN = {0003-6935}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20212888}, Abstract = {The argon laser for diabetic retinopathy therapy was originally selected for photocoagulation by matching peak emission to hemoglobin absorption to maximize obliteration of retinal blood vessels. Present clinical experience in the treatment of diabetic retinopathy does not show any marked advantage of argon lasers over ruby and xenon photocoagulators not matched to hemoglobin absorption. The efficacy of photocoagulation is shown to depend upon the interaction between choroidal and retinal blood supplies in tissue oxygenation and depends upon pigment epithelium absorption to destroy rods and cones. Design specifications for new laser photocoagulators and alternative (supplemental) therapy for diabetic retinopathy are given.}, Key = {fds254649} } @article{fds291138, Author = {WOLBARSHT, ML}, Title = {SUPERSUMMATION AND AFTERIMAGES}, Journal = {Behavioral and Brain Sciences}, Volume = {2}, Number = {2}, Pages = {289-289}, Year = {1979}, ISSN = {0140-525X}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1979JA57300097&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Doi = {10.1017/S0140525X00062610}, Key = {fds291138} } @article{fds323497, Author = {Wolbarsht, ML}, Title = {Optical design reflectors: Part 3: comments.}, Journal = {Applied Optics}, Volume = {17}, Number = {23}, Pages = {3705-3706}, Year = {1978}, Month = {December}, Key = {fds323497} } @article{fds254647, Author = {Cope, WT and Wolbarsht, ML and Yamanashi, BS}, Title = {The corneal polarization cross.}, Journal = {Journal of the Optical Society of America}, Volume = {68}, Number = {8}, Pages = {1139-1141}, Year = {1978}, Month = {August}, ISSN = {0030-3941}, url = {http://www.ncbi.nlm.nih.gov/pubmed/712454}, Abstract = {The corneal polarization cross can be seen at the human cornea using crossed polaroids. The optical mechanisms for this phenomena include rotation and retardation of the light at the surface of the cornea due to the corneal curvature, as well as retardation due to an average circumferential orientation of the birefringent corneal collagen.}, Key = {fds254647} } @article{fds254646, Author = {Wolbarsht, ML}, Title = {Electrophysiological determination of retinal sensitivity to color after intense monochromatic light adaptation}, Volume = {SAM-TR-78-9}, Year = {1978}, Abstract = {Techniques were developed to record retinal ganglion-cell responses. Categories of cell types in the cat retina were established in which X, Y, and W cell types were found with both cones and rods. The cones were connected in combinations selected from three groups whose γ(max) were 450, 500, and 555 nm. The receptive field organization showed center-surround characteristics interaction, including antagonism between cone types. Strong light adaptation showed independence of each cone group from any other in their influence upon the ganglion cells, which was confirmed by the separate recovery of sensitivity by each group. Both the loss and recovery of sensitivity in various parts of the receptive field were demonstrated. No special deleterious effects of strong light adaptation on the 450 λ(max) cone were observed. Good stability of recording techniques was achieved with single cells maintained 10 hours or more. The central portion of the retina was studied intensively, demonstrating the feasibility of recording from the macular or foveal region in rhesus monkeys.}, Key = {fds254646} } @article{fds254643, Author = {Ringo, J and Wolbarsht, ML and Wagner, HG and Crocker, R and Amthor, F}, Title = {Trichromatic vision in the cat.}, Journal = {Science (New York, N.Y.)}, Volume = {198}, Number = {4318}, Pages = {753-755}, Year = {1977}, Month = {November}, ISSN = {0036-8075}, url = {http://www.ncbi.nlm.nih.gov/pubmed/910161}, Abstract = {Many cat retinal ganglion cells (types X, Y, and W) have inputs from three separate cone systems. Those with peak sensitivities at 450 and 555 nanometers have been previously shown. A gamma max cone with a peak sensitivity of 500 nanometers can be differentiated from other cones by spectral sensitivity and from rods by receptive field differences, functioning above rod saturation levels, and by cone-rod breaks in the dark-adaptation curves. The similarity of the three-cone cat retina to the extramacular retina of the rhesus monkeys suggests that the cat may have photopic trichromatic vision.}, Key = {fds254643} } @article{fds254642, Author = {Wadsworth, JA and Wolbarsht, ML and Bessler, M and Hickingbotham, D}, Title = {A portable system for external photography.}, Journal = {American Journal of Ophthalmology}, Volume = {84}, Number = {1}, Pages = {123-125}, Year = {1977}, Month = {July}, ISSN = {0002-9394}, url = {http://www.ncbi.nlm.nih.gov/pubmed/900212}, Abstract = {A portable system for external photography combines a focusing lamp and movable flash unit with a wide focusing range. The system is arranged to operate from a single two-position trigger and may be hand-held or mounted on a slitlamp stand. It is designed for use in general ophthalmology in a multilaned office practice or bedside use in a hospital situation.}, Key = {fds254642} } @article{fds254639, Author = {Wolbarsht, ML and Landers, MB}, Title = {Current trends in therapy: theory and practice. Introduction.}, Journal = {Advances in Experimental Medicine and Biology}, Volume = {77}, Pages = {179-180}, Year = {1977}, ISSN = {0065-2598}, url = {http://www.ncbi.nlm.nih.gov/pubmed/848391}, Key = {fds254639} } @article{fds254640, Author = {Wolbarsht, ML and Landers, MB and Wadsworth, JA and Anderson, WB}, Title = {Retinitis pigmentosa: clinical management based on current concepts.}, Journal = {Advances in Experimental Medicine and Biology}, Volume = {77}, Pages = {181-195}, Year = {1977}, ISSN = {0065-2598}, url = {http://www.ncbi.nlm.nih.gov/pubmed/300550}, Key = {fds254640} } @article{fds254644, Author = {Holland, PM and III, MBL and Lebovitz, HE and Wolbarsht, M}, Title = {Reply}, Journal = {American Journal of Ophthalmology}, Volume = {83}, Number = {6}, Pages = {930-}, Year = {1977}, ISSN = {0002-9394}, Key = {fds254644} } @article{fds254645, Author = {Wolbarsht, ML}, Title = {Tests for glare sensitivity and peripheral vision in driver applicants}, Journal = {Journal of Safety Research}, Volume = {9}, Number = {3}, Pages = {128-139}, Year = {1977}, Abstract = {A report is given of field trials of a version of the standard vision tests modified to provide both a quantitative measure of susceptibility to glare and defects in peripheral vision. Approximately 1500 driver applicants were examined in 30 stations throughout the state. The distribution of elevated glare sensitivity and defects in peripheral vision in the driving population were determined and correlated with individual accident records. There were clear indications that a large percentage of older drivers had elevated glare sensitivity. Those drivers limited their driving to nonglare conditions in many cases. Future lines of investigation indicated by the present study are a correlation between this test and the present standard used by the Medical Evaluation Board for restriction to daytime driving. More data is needed on driver applicants over the age of 50 about possible elevations in glare sensitivity and accident records. The peripheral vision tester was satisfactory in all respects and it is recommended that it be adopted for general use.}, Key = {fds254645} } @article{fds254635, Author = {Holland, PM and Landers, MB and Lebovitz, HE and Wolbarsht, ML}, Title = {Levodopa-stimulated growth hormone secretion and diabetic retinopathy.}, Journal = {American Journal of Ophthalmology}, Volume = {82}, Number = {4}, Pages = {612-618}, Year = {1976}, Month = {October}, ISSN = {0002-9394}, url = {http://www.ncbi.nlm.nih.gov/pubmed/970425}, Abstract = {Since growth hormone has been implicated as a possible etiologic factor in the development of diabetic retinopathy, we examined growth hormone levels in two groups of growth-onset diabetics matched for age and duration of disease. The experimental group had definite proliferative diabetic retinopathy; the control group of growth-onset diabetics had no significant retinopathy. Basal and levodopa-stimulated levels of growth hormone were determined for each group. Growth hormone response could not be correlated with the presence or absence of diabetic retinopathy (P less than .05).}, Key = {fds254635} } @article{fds254641, Author = {Sliney, DH and Wangemann, RT and Franks, JK and Wolbarsht, ML}, Title = {Visual sensitivity of the eye to infrared laser radiation.}, Journal = {Journal of the Optical Society of America}, Volume = {66}, Number = {4}, Pages = {339-341}, Year = {1976}, Month = {April}, ISSN = {0030-3941}, url = {http://www.ncbi.nlm.nih.gov/pubmed/1262982}, Abstract = {The foveal sensitivity to several near-infrared laser wavelengths was measured. It was found that the eye could respond to radiation at wavelengths at least as far as 1064 nm. A continuous 1064 nm laser source appeared red, but a 1060 nm pulsed laser source appeared green, which suggests the presence of harmonic generation in the retina.}, Key = {fds254641} } @article{fds254631, Author = {Landers, MB and Wolbarsht, ML and Shaw, HE}, Title = {The current status of laser usage in ophthalmology.}, Journal = {Annals of the New York Academy of Sciences}, Volume = {267}, Pages = {230-246}, Year = {1976}, Month = {January}, ISSN = {0077-8923}, url = {http://www.ncbi.nlm.nih.gov/pubmed/818931}, Key = {fds254631} } @article{fds254638, Author = {Wolbarsht, ML}, Title = {The function of intraocular color filters.}, Journal = {Federation Proceedings}, Volume = {35}, Number = {1}, Pages = {44-50}, Year = {1976}, Month = {January}, ISSN = {0014-9446}, url = {http://www.ncbi.nlm.nih.gov/pubmed/173583}, Key = {fds254638} } @article{fds254634, Author = {Stein, PJ and Henkens, RW and Yamanashi, BS and Wolbarsht, M}, Title = {Studies on brunescent cataracts. II. Fluorescence studies on normal and brunescent lens proteins}, Journal = {Ophthalmic Research}, Volume = {8}, Number = {5}, Pages = {388-394}, Year = {1976}, Abstract = {The fluorescence of both water-soluble and water-insoluble protein fractions from normal and brunescent lens was measured. Among the solvents used, sodium dodecyl sulfate and guanidinium chloride do not destroy the primary structure of the lens protein. The non-amino acid fluorescence intensity increases in the insoluble fractions of both normal and cataractous lenses. Similar results were obtained using digests of the lens protein solutions. The yellow color of brunescent cataracts is associated predominantly with the fraction that is insoluble even in dodecyl sulfate and dithiothreitol. It is suggested that the fluorescence and the yellow pigmentation associated with brunescent lenses do not result from the same compound.}, Key = {fds254634} } @article{fds254636, Author = {Jr, JSZ and Jr, JBS and Yamanashi, BS and Wolbarsht, M}, Title = {Studies on brunescent cataracts. I. Analysis of free and protein bound amino acids}, Journal = {Ophthalmic Research}, Volume = {8}, Number = {5}, Pages = {379-387}, Year = {1976}, Abstract = {The concentrations of free amino acids and the composition of protein-bound amino acids have been determined from normal human lens and from human brunescent cataracts. The concentrations of free amino acids are markedly and consistently reduced in brunescent lenses. Little change is found in the amino acid composition of either the soluble or water-insoluble proteins when normal and brunescent lenses are compared. Low concentrations of kynurenine were present in all lens protein hydrolysates and in the free amino acid pool. There appeared to be no significant decrease in protein-bound tryptophan in the brunescent lens.}, Key = {fds254636} } @article{fds254637, Author = {Wolbarsht, ML and Landers, MB and Robinson, CH and Hickingbotham, D}, Title = {A micromanipulator for intraocular surgery.}, Journal = {Ophthalmic Surgery}, Volume = {7}, Number = {2}, Pages = {51-54}, Year = {1976}, ISSN = {0022-023X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/934600}, Key = {fds254637} } @article{fds254732, Author = {Wolbarsht, ML}, Title = {Structure and function of the visual system. Introductory remarks}, Journal = {Federation Proceedings}, Volume = {35}, Number = {1}, Pages = {36-}, Year = {1976}, Key = {fds254732} } @article{fds254601, Author = {Yasuda, H and Bumgarner, MO and Marsh, HC and Yamanashi, BS and Devito, DP and Wolbarsht, ML and Reed, JW and Bessler, M and Landers, MB and Hercules, DM and Carver, J}, Title = {Ultrathin coating by plasma polymerization applied to corneal contact lens.}, Journal = {Journal of Biomedical Materials Research}, Volume = {9}, Number = {6}, Pages = {629-643}, Year = {1975}, Month = {November}, ISSN = {0021-9304}, url = {http://www.ncbi.nlm.nih.gov/pubmed/1184610}, Abstract = {Plasma coating (deposition of polymer under the influence of plasma) is utilized to modify the surface properties of corneal contact lens. An ultrathin layer (thickness of roughly 200 A) of plasma polymer of acetylene/H20/N2 is applied to poly(methyl methacrylate) (PMMA) corneal contact lenses. The surface becomes highly wettable with water compared to uncoated lens. When coated and uncoated contact lenses are placed on rabbit eyes, a remarkable difference in accumulation of mucous matter is observed. With the control lenses, the accumulation of mucous matter in a week is sufficient to affect the optical clarity of the lenses, whereas the coated lenses show no change after three months continuous wearing. The comparative degree of adhesion of the corneal epithelium cells onto glass, modified glass, PMMA, and coated PMMA surfaces is studied using tissue cultures and phase contrast microscopy. The coated PMMA surface exhibits a degree of tissue adhesion lower than that of control PMMA and higher than that of glass surface, and no sign of toxicity of the coated surface is observed by the tissue cultures.}, Doi = {10.1002/jbm.820090609}, Key = {fds254601} } @article{fds254632, Author = {White, CW and Wolbarsht, ML and Tieger, T}, Title = {A fast visual colorimeter}, Journal = {Behavior Research Methods}, Volume = {7}, Number = {3}, Pages = {260-264}, Year = {1975}, ISSN = {1554-351X}, url = {http://dx.doi.org/10.3758/BF03201443}, Abstract = {A simple colorimeter is described which enables untrained observers to rapidly and reliably match hue and saturation using a novel joystick control. The colorimeter output is suitable for computer recording and analysis. The applications of this color-matching technique in experiments requiring speed and simplicity are illustrated. © 1975 Psychonomic Society, Inc.}, Doi = {10.3758/BF03201443}, Key = {fds254632} } @article{fds254633, Author = {Wolbarsht, ML}, Title = {The demise of the Neanderthals: Was language a factor?}, Journal = {Science (New York, N.Y.)}, Volume = {187}, Number = {4177}, Pages = {600-601}, Year = {1975}, ISSN = {0036-8075}, Key = {fds254633} } @article{fds254628, Author = {Wolbarsht, ML}, Title = {Use of grant funds.}, Journal = {Science (New York, N.Y.)}, Volume = {185}, Number = {4149}, Pages = {399}, Year = {1974}, Month = {August}, ISSN = {0036-8075}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17743066}, Doi = {10.1126/science.185.4149.399-a}, Key = {fds254628} } @article{fds254625, Author = {Matheson, IBC and Lee, J and Yamanashi, BS and Wolbarsht, ML}, Title = {Measurement of the absolute rate constants for singlet molecular oxygen(1Δg) reaction with 1,3-diphenylisobenzofuran and physical quenching by ground state molecular oxygen}, Journal = {Journal of the American Chemical Society}, Volume = {96}, Number = {11}, Pages = {3343-3348}, Year = {1974}, ISSN = {0002-7863}, Abstract = {Singlet oxygen (1Δg) has been produced in Freon 113 solution by pumping the oxygen 1Δg + 1v ← 3Σg- electronic transition by 1.06 μm radiation from a continuous Nd-YAG laser or a Q-switched Nd-glass laser. The singlet oxygen thus produced was detected by reaction with the acceptor 1,3-diphenylisobenzofuran (DPBF) Comparison of the amount of DPBF concentration change with the amount of singlet oxygen produced has shown that the rate constant of reaction of DPBF with singlet oxygen obtained by Merkel and Kearns and others is an order of magnitude too high but corresponds to the total rate constant which we measure for reaction plus quenching. The rate of quenching of singlet oxygen by ground state oxygen has been measured to be 2.7 × 103 l. mol-1 sec-1 in Freon 113, only twice the rate in the gas phase measured by Wayne and others. © Copyright, 1974, by the American Chemical Society.}, Key = {fds254625} } @article{fds254629, Author = {Matheson, IBC and Lee, J and Yamanashi, BS and Wolbarsht, ML}, Title = {Observation of the singlet oxygen dimol emission from neodymium laser pumped oxygen in the gas phase and in 1,1,2-trichlorotrifluoroethane solution}, Journal = {Chemical Physics Letters}, Volume = {27}, Number = {3}, Pages = {355-358}, Year = {1974}, ISSN = {0009-2614}, Abstract = {Dimol emission 2O2(1Δg) → 2O2(3Σg-) + hν633nm has been observed from neodymium glass laser pumped oxygen in the gas phase and in 1,1,2-trichlorotrifluoroethane solution. The emission lifetime is dependent on quenching by ground state oxygen, and the quenching rate constants determined in this work are consistent with literature values. © 1974.}, Key = {fds254629} } @article{fds254630, Author = {Wolbarsht, ML and Yamanashi, BS}, Title = {Browning of the lens in generalized albinism}, Journal = {American Journal of Ophthalmology}, Volume = {78}, Number = {5}, Pages = {874-}, Year = {1974}, ISSN = {0002-9394}, Key = {fds254630} } @article{fds254626, Author = {Kurzel, RB and Wolbarsht, ML and Yamanashi, BS}, Title = {Spectral studies on normal and cataractous intact human lenses.}, Journal = {Experimental Eye Research}, Volume = {17}, Number = {1}, Pages = {65-71}, Year = {1973}, Month = {October}, ISSN = {0014-4835}, url = {http://www.ncbi.nlm.nih.gov/pubmed/4752363}, Key = {fds254626} } @article{fds254627, Author = {Kurzel, RB and Wolbarsht, M and Yamanashi, BS and Staton, GW and Borkman, RF}, Title = {Tryptophan excited states and cataracts in the human lens [20]}, Journal = {Nature}, Volume = {241}, Number = {5385}, Pages = {132-133}, Year = {1973}, ISSN = {0028-0836}, url = {http://dx.doi.org/10.1038/241132a0}, Doi = {10.1038/241132a0}, Key = {fds254627} } @article{fds254624, Author = {Spekreijse, H and Wagner, HG and Wolbarsht, ML}, Title = {Spectral and spatial coding of ganglion cell responses in goldfish retina.}, Journal = {Journal of Neurophysiology}, Volume = {35}, Number = {1}, Pages = {73-86}, Year = {1972}, Month = {January}, ISSN = {0022-3077}, url = {http://www.ncbi.nlm.nih.gov/pubmed/5008725}, Doi = {10.1152/jn.1972.35.1.73}, Key = {fds254624} } @article{fds254623, Author = {Norton, AL and Spekreijse, H and Wagner, HG and Wolbarsht, ML}, Title = {Responses to directional stimuli in retinal preganglionic units.}, Journal = {The Journal of Physiology}, Volume = {206}, Number = {1}, Pages = {93-107}, Year = {1970}, Month = {January}, ISSN = {0022-3751}, url = {http://www.ncbi.nlm.nih.gov/pubmed/5498462}, Abstract = {1. Extracellular recordings were made from directionally selective ganglion cell units in the isolated frog retina and decapitated Necturus preparation.2. Intracellular recordings were made from individual photoreceptor cells in the frog and Necturus retinae while stimuli which had evoked directionally selective responses at the ganglion cell level were presented. No evidence for inhibition of photoreceptors for any direction of movement of the light stimulus was found. This appeared to rule out a mechanism for directional selectivity involving inhibition of photoreceptor potentials.3. Intracellular recordings were made from the nuclear layer between photoreceptors and ganglion cells in Necturus. The responses were of two types: either transitory or sustained.4. The sustained type responses could be divided into two classes depending on their receptive field organization. One type of sustained potential had a large receptive field without any evidence for a centre-surround antagonism and corresponded to the luminosity type S-potential recorded in fish. The other type had a smaller receptive field and showed a difference in sign of response between centre and surround if the centre was flooded with a steady light. This is very similar to what has been described for a type of on-centre, off-surround ganglion cell.5. The transitory type of responses showed some centre-surround antagonistic organization. Some of these transitory units also appeared to show some discrimination in response as a function of the distribution of light on the retina.6. No specific directional selectivity was found from units at the inner nuclear layer. This further excluded any mechanism of directional sensitivity which involves selectivity at the photoreceptor level.7. It was concluded that although inner nuclear layer units may play a role in the mechanism of directional selectivity, no specific directionality was found at the first synaptic level of the retina.}, Key = {fds254623} } @article{fds323498, Author = {Clarke, A and Wolbarsht, ML}, Title = {Ocular hazards from lasers and other optical sources}, Journal = {CRC CRITICAL REV. IN ENVIRON. CONTROL}, Volume = {1}, Number = {1-4}, Pages = {307-339}, Year = {1970}, Month = {January}, url = {http://dx.doi.org/10.1080/10643387009381569}, Doi = {10.1080/10643387009381569}, Key = {fds323498} } @article{fds254621, Author = {Norton, AL and Spekreijse, H and Wolbarsht, ML and Wagner, HG}, Title = {Receptive field organization of the S-potential.}, Journal = {Science (New York, N.Y.)}, Volume = {160}, Number = {3831}, Pages = {1021-1022}, Year = {1968}, Month = {May}, ISSN = {0036-8075}, url = {http://www.ncbi.nlm.nih.gov/pubmed/5647849}, Abstract = {The receptive fields of S-potentials have been studied in carp retinas. The relationship between the stimulus intensity and area of stimulation was examined for each component of three different types of S-potential. It appears that for each component there is full summation over a large portion of the retina, a type of organization different from that found in the ganglion cell.}, Key = {fds254621} } @article{fds254622, Author = {Hayes, JR and Wolbarsht, ML}, Title = {Thermal model for retinal damage induced by pulsed lasers.}, Journal = {Aerospace Medicine}, Volume = {39}, Number = {5}, Pages = {474-480}, Year = {1968}, Month = {May}, ISSN = {0001-9402}, url = {http://www.ncbi.nlm.nih.gov/pubmed/5648735}, Key = {fds254622} } @article{fds254619, Author = {Gillary, HL and Wolbarsht, ML}, Title = {Electrical responses from the eye of a land snail.}, Journal = {Revue Canadienne de Biologie}, Volume = {26}, Number = {2}, Pages = {125-134}, Year = {1967}, Month = {June}, ISSN = {0035-0915}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6065915}, Key = {fds254619} } @article{fds254618, Author = {Wolbarsht, ML and Yeandle, SS}, Title = {Visual processes in the Limulus eye.}, Journal = {Annual Review of Physiology}, Volume = {29}, Pages = {513-542}, Year = {1967}, ISSN = {0066-4278}, url = {http://www.ncbi.nlm.nih.gov/pubmed/5335441}, Doi = {10.1146/annurev.ph.29.030167.002501}, Key = {fds254618} } @article{fds254620, Author = {Wolbarsht, ML}, Title = {Decrement in visual acuity from laser lesions in the fovea.}, Journal = {Aerospace Medicine}, Volume = {37}, Number = {12}, Pages = {1250-1252}, Year = {1966}, Month = {December}, ISSN = {0001-9402}, url = {http://www.ncbi.nlm.nih.gov/pubmed/4961718}, Key = {fds254620} } @article{fds254616, Author = {Yarczower, M and Wolbarsht, ML and Galloway, WD and Fligsten, KE and Malcolm, R}, Title = {Visual acuity in a stumptail macaque.}, Journal = {Science (New York, N.Y.)}, Volume = {152}, Number = {3727}, Pages = {1392-1393}, Year = {1966}, Month = {June}, ISSN = {0036-8075}, url = {http://www.ncbi.nlm.nih.gov/pubmed/4957015}, Abstract = {Visual acuity in a normal stumptail macaque is 1.4 minutes of arc-similar to man's. Destruction of the fovea by photocoagulation decreased acuity to 9 minutes of arc. These facts suggest that the fovea in the macaque has the same physiological role in visual acuity as in man.}, Key = {fds254616} } @article{fds254600, Author = {Van Buskirk and C and Wolbarsht, ML and Stecher, K}, Title = {The nonnervous causes of normal physiologic tremor.}, Journal = {Neurology}, Volume = {16}, Number = {2}, Pages = {217-220}, Year = {1966}, Month = {February}, ISSN = {0028-3878}, url = {http://www.ncbi.nlm.nih.gov/pubmed/5948513}, Key = {fds254600} } @article{fds254595, Author = {Fligsten, K and Wolbarsht, M}, Title = {A diffusely transmitting, integrating sphere for measuring laser output with a phototransistor}, Journal = {Proceedings of the Ieee}, Volume = {54}, Number = {8}, Pages = {1109-1110}, Year = {1966}, ISSN = {0018-9219}, url = {http://dx.doi.org/10.1109/PROC.1966.5033}, Doi = {10.1109/PROC.1966.5033}, Key = {fds254595} } @article{fds254617, Author = {Yarczower, M and Wolbarsht, ML and Galloway, WD and Fligsten, KE and Malcolm, R}, Title = {Erratum: Visual acuity in a stumptail macaque (Science (June, 1966) 152 (1392))}, Journal = {Science (New York, N.Y.)}, Volume = {152}, Number = {3730}, Pages = {1730-}, Year = {1966}, ISSN = {0036-8075}, Key = {fds254617} } @article{fds254614, Author = {Wolbarsht, ML and Fligsten, KE and Hayes, JR}, Title = {Retina: pathology of neodymium and ruby laser burns.}, Journal = {Science (New York, N.Y.)}, Volume = {150}, Number = {3702}, Pages = {1453-1454}, Year = {1965}, Month = {December}, ISSN = {0036-8075}, url = {http://www.ncbi.nlm.nih.gov/pubmed/4955019}, Abstract = {Chorioretinal lesions hiave been prodluced in monkeys during experitments with ruby and neodlymium lasers. Most of the energy from the ruby laser (wavelength 6943 angstroms) is absorbed by the pigment epithelium, where the greatest damage appears. With the neodymium laser (10,600 angstroms) the neural portions of the retina absorb more of damage than the pigment epithelium and adjacent tissues.}, Key = {fds254614} } @article{fds254612, Author = {Wolbarsht, ML}, Title = {Receptor sites in insect chemoreceptors.}, Journal = {Cold Spring Harbor Symposia on Quantitative Biology}, Volume = {30}, Pages = {281-288}, Year = {1965}, ISSN = {0091-7451}, url = {http://www.ncbi.nlm.nih.gov/pubmed/5219481}, Key = {fds254612} } @article{fds254615, Author = {WOLBARSHT, ML and HANSON, FE}, Title = {ELECTRICAL ACTIVITY IN THE CHEMORECEPTORS OF THE BLOWFLY. 3. DENDRITIC}, Journal = {The Journal of General Physiology}, Volume = {48}, Pages = {673-683}, Year = {1965}, ISSN = {0022-1295}, Key = {fds254615} } @article{fds254613, Author = {Wolbarsht, ML and Stopp, PE and Goodson, JE}, Title = {Ophthalmoscopy of pigeons using transillumination.}, Journal = {Experientia}, Volume = {20}, Number = {8}, Pages = {466-467}, Year = {1964}, Month = {August}, ISSN = {0014-4754}, url = {http://www.ncbi.nlm.nih.gov/pubmed/5856886}, Key = {fds254613} } @article{fds254596, Author = {Wolbarsht, ML}, Title = {In defense of gadgeteering, a second look}, Volume = {10}, Number = {1}, Pages = {2-2}, Year = {1963}, Month = {January}, ISSN = {0096-0616}, url = {http://dx.doi.org/10.1109/TBMEL.1963.4322773}, Doi = {10.1109/TBMEL.1963.4322773}, Key = {fds254596} } @article{fds254599, Author = {WOLBARSHT, ML}, Title = {IN DEFENSE OF GADGETEERING, A SECOND LOOK.}, Journal = {Ieee Transactions on Bio Medical Engineering}, Volume = {10}, Pages = {29-36}, Year = {1963}, Month = {January}, ISSN = {0018-9294}, url = {http://www.ncbi.nlm.nih.gov/pubmed/14059528}, Key = {fds254599} } @article{fds254611, Author = {WAGNER, HG and MACNICHOL, EF and WOLBARSHT, ML}, Title = {Functional basis for "on"-center and "off"-center receptive fields in the retina.}, Journal = {Journal of the Optical Society of America}, Volume = {53}, Pages = {66-70}, Year = {1963}, Month = {January}, ISSN = {0030-3941}, url = {http://www.ncbi.nlm.nih.gov/pubmed/13998241}, Doi = {10.1364/josa.53.000066}, Key = {fds254611} } @article{fds254610, Author = {MILLER, WH and WOLBARSHT, ML}, Title = {Neural activity in the parietal eye of a lizard.}, Journal = {Science (New York, N.Y.)}, Volume = {135}, Number = {3500}, Pages = {316-317}, Year = {1962}, Month = {January}, ISSN = {0036-8075}, url = {http://www.ncbi.nlm.nih.gov/pubmed/14474119}, Abstract = {Electrical signs of activity in response to illumination of the parietal eye of the American chameleon, Anolis carolinensis, have been investigated. The responses were of two types. Under conditions of direct-coupled amplification, with glass pipette electrodes recording extracellularly from the retinal surface, the response consisted of an increase in negativity maintained throughout prolonged illumination. With capacitance-coupled amplification and metal electrodes, brisk mass discharges of nerve impulses were detected at the onset and cessation of illumination. During illumination a less vigorous maintained discharge was observed.}, Doi = {10.1126/science.135.3500.316}, Key = {fds254610} } @article{fds254607, Author = {Wolbarsht, ML and Macnichol, EF and Wagner, HG}, Title = {Glass Insulated Platinum Microelectrode.}, Journal = {Science (New York, N.Y.)}, Volume = {132}, Number = {3436}, Pages = {1309-1310}, Year = {1960}, Month = {November}, ISSN = {0036-8075}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17753062}, Abstract = {Microelectrodes for electrophysiological use have been prepared easily and quickly by electrolytically sharpening platinum iridium alloy wire and coating with molten glass. The desirable combination of the electrical characteristics and strength of the platinum iridium wire with the exceptional durability of glass insulation has long been known, but earlier methods of fabrication were difficult and tedious.}, Doi = {10.1126/science.132.3436.1309}, Key = {fds254607} } @article{fds254598, Author = {OTOMO, E and WOLBARSHT, ML and VAN BUSKIRK and C and DAVIDSON, M}, Title = {A comparison of spinal cord, cortical and superficial circulation.}, Journal = {The Journal of Nervous and Mental Disease}, Volume = {131}, Pages = {418-427}, Year = {1960}, Month = {November}, ISSN = {0022-3018}, url = {http://www.ncbi.nlm.nih.gov/pubmed/13731597}, Key = {fds254598} } @article{fds254609, Author = {WOLBARSHT, ML}, Title = {Electrical characteristics of insectmechanoreceptors.}, Journal = {The Journal of General Physiology}, Volume = {44}, Pages = {105-122}, Year = {1960}, Month = {September}, ISSN = {0022-1295}, url = {http://www.ncbi.nlm.nih.gov/pubmed/13786239}, Abstract = {External direct coupled recordings from the neurons of the mechanosensory hairs of insects show nerve impulses and graded slow potentials in response to deformation of the hair. These slow potentials or receptor potentials are negative going, vary directly with the magnitude of the stimulus, and show no overshoot when returning to baseline. The impulses have an initial positive phase which varies in size directly with the amplitude of the receptor potential. The receptor potential is related to the generator potential for the impulse in that it must attain some critical level before impulses are produced, and the frequency of impulses varies directly with amplitude of the receptor potential. The receptor potential does not return to the baseline after each impulse. In some receptors static deformation of the hair will maintain the receptor potential. It appears likely that both the receptor potential and the variation in size of the impulses are caused by a change in conductance of the cell membrane at the receptor site, and that the receptor potential originates at a site which is not invaded by the propagated impulses.}, Key = {fds254609} } @article{fds328073, Author = {Wagner, HG and Macnichol, EF and Wolbarsht, ML}, Title = {The Response Properties of Single Ganglion Cells in the Goldfish Retina.}, Journal = {The Journal of General Physiology}, Volume = {43}, Number = {6}, Pages = {45-62}, Year = {1960}, Month = {July}, Key = {fds328073} } @article{fds254608, Author = {Wagner, HG and Macnichol, EF and Wolbarsht, ML}, Title = {Opponent Color Responses in Retinal Ganglion Cells.}, Journal = {Science (New York, N.Y.)}, Volume = {131}, Number = {3409}, Pages = {1314}, Year = {1960}, Month = {April}, ISSN = {0036-8075}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17784397}, Abstract = {The receptive fields of certain ganglion cells in the goldfish retina have been mapped. These fields are "off" center. "on-off" intermediate, and "on" periphery types. The excitatory process controlling the "on" response is stimulated maximally by green light; the "off" response process, inhibitory in nature, is stimulated maximally by red light. The two processes can be light adapted independently.}, Doi = {10.1126/science.131.3409.1314}, Key = {fds254608} } @article{fds323499, Author = {WOLBARSHT, ML and DETHIER, VG}, Title = {Electrical activity in the chemoreceptors of the blowfly. I. Responses to chemical and mechanical stimulation.}, Journal = {The Journal of General Physiology}, Volume = {42}, Number = {2}, Pages = {393-412}, Year = {1958}, Month = {November}, Abstract = {The electrical responses of the neurons associated with the various types of chemosensory hairs of the blowfly, Phormia regina Meigen, following stimulation by chemical and mechanical means have been studied. The singly innervated chemosensory hairs on the ovipositor, maxillary palpi, and antennae respond vigorously to chemical stimulation, but not to mechanical stimulation. The triply innervated chemosensory hairs on the labellum, tarsus, and wing have two neurons which respond only to chemical stimuli. The third neuron responds only to mechanical stimulation. The differential responses of the two chemosensory neurons to various chemical stimuli following the removal of the tip of the hair suggest that the structures responsible for chemoreception are located throughout the distal processes of these neurons. The response of the third neuron to mechanical stimulation is similar to the response recorded from the neuron associated with one type of tactile hair which responds to motion and not to steady deformation. Recordings have been made from the neurons associated with purely tactile hairs using the cut hair as an extension of the micropipette. The mechanosensory neuron of the wing chemosensory hair is capable of responding at the rate of at least 600 impulses per sec. and may serve to indicate changes in air flow over the wing surfaces during flight to enable the fly to correct the wing camber and attack angle.}, Key = {fds323499} } @article{fds323500, Author = {WOLBARSHT, ML}, Title = {Electrical activity in the chemoreceptors of the blowfly. II. Responses to electrical stimulation.}, Journal = {The Journal of General Physiology}, Volume = {42}, Number = {2}, Pages = {413-428}, Year = {1958}, Month = {November}, Abstract = {An analysis of the various parts of the electrical responses to the chemical and electrical stimulation of a single labellar chemosensory hair of the blowfly, Phormia regina, indicates that the recording conditions for the spike potentials approximate the intracellular recordings made in other types of sense cells. The large positive resting potential probably arises from the basement membrane of the hypodermal cells and neurilemma rather than from the neurons at the base of the chemosensory hair. The responses to polarizing currents passed through single chemosensory hairs support this analysis. The behavioral responses to similar polarizing currents are shown to result from the action of the current on the neurons at the bases of the adjacent chemosensory hairs. The reported neural interaction of the two chemosensory neurons associated with the chemosensory hair is probably due to the physical-chemical attributes of the stimulating solution rather than to any real neural interaction. Observations on the latency of the initial nerve impulse in response to chemical stimulation indicate that the chemosensory neurons are normally free from spontaneous spike activity.}, Key = {fds323500} } @article{fds254605, Author = {WAGNER, HG and WOLBARSHT, ML}, Title = {Studies on the functional organization of the vertebrate retina.}, Journal = {American Journal of Ophthalmology}, Volume = {46}, Number = {3 Part 2}, Pages = {46-55}, Year = {1958}, Month = {September}, ISSN = {0002-9394}, url = {http://www.ncbi.nlm.nih.gov/pubmed/13571358}, Key = {fds254605} } @article{fds254604, Author = {Wolbarsht, ML}, Title = {Water Taste in Phormia.}, Journal = {Science (New York, N.Y.)}, Volume = {125}, Number = {3260}, Pages = {1248}, Year = {1957}, Month = {June}, ISSN = {0036-8075}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17799357}, Doi = {10.1126/science.125.3260.1248}, Key = {fds254604} } @article{fds254606, Author = {DETHIER, VG and WOLBARSHT, ML}, Title = {The electron microscopy of chemosensory hairs.}, Journal = {Experientia}, Volume = {12}, Number = {9}, Pages = {335-337}, Year = {1956}, Month = {September}, ISSN = {0014-4754}, url = {http://www.ncbi.nlm.nih.gov/pubmed/13365586}, Key = {fds254606} } | |
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