Psychology and Neuroscience
Arts & Sciences
Duke University
| |
Faculty Database Psychology and Neuroscience Arts & Sciences Duke University |
|
| HOME > Arts & Sciences > pn > Faculty | Search Help Login |
|
| Publications of Deborah T. Gold :chronological alphabetical combined listing:
%% Journal Articles
@article{fds352908,
Author = {Gold, DT and Weiss, R and Wang, Y and Williams, S and Roberts, J and Bailey, T},
Title = {A Real-World Study of the Patient Experience of Osteoporosis
Following Treatment with Abaloparatide},
Journal = {Journal of Bone and Mineral Research},
Volume = {34},
Pages = {260-260},
Publisher = {WILEY},
Year = {2019},
Month = {December},
Key = {fds352908}
}
@article{fds352909,
Author = {Gold, DT and Weiss, R and Wang, Y and Williams, S and Roberts, J and Bailey, T},
Title = {A Real-World Study of the Patient Experience of Osteoporosis
Following Treatment with Abaloparatide},
Journal = {Journal of Bone and Mineral Research},
Volume = {34},
Pages = {260-260},
Publisher = {WILEY},
Year = {2019},
Month = {December},
Key = {fds352909}
}
@article{fds272794,
Author = {Silverman, SL and Siris, E and Kendler, DL and Belazi, D and Brown, JP and Gold, DT and Lewiecki, EM and Papaioannou, A and Simonelli, C and Ferreira, I and Balasubramanian, A and Dakin, P and Ho, P and Siddhanti,
S and Stolshek, B and Recknor, C},
Title = {Persistence at 12 months with denosumab in postmenopausal
women with osteoporosis: interim results from a prospective
observational study},
Journal = {Osteoporosis International : a Journal Established as Result
of Cooperation Between the European Foundation for
Osteoporosis and the National Osteoporosis Foundation of the
Usa},
Volume = {26},
Number = {1},
Pages = {361-372},
Publisher = {Springer-Verlag London Ltd},
Year = {2014},
Month = {September},
ISSN = {0004-3591},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000325359203221&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Abstract = {Summary: To determine persistence with subcutaneous
denosumab every 6 months in women being treated for
osteoporosis, we conducted a single-arm prospective,
observational study in the United States and Canada. Among
935 patients enrolled, 12-month persistence was 82 %, with
66 patients (7 %) reporting serious adverse events and 19
patients (2 %) reporting fractures.},
Doi = {10.1007/s00198-014-2871-6},
Key = {fds272794}
}
@article{fds316723,
Author = {Gold, DT and Calderon, A and Silverman, SL},
Title = {RACE/ETHNICITYAND SES INFLUENCE OUTCOMES OF OSTEOPOROSIS
EDUCATIONAL INTERVENTIONS},
Journal = {Osteoporosis International : a Journal Established as Result
of Cooperation Between the European Foundation for
Osteoporosis and the National Osteoporosis Foundation of the
Usa},
Volume = {25},
Pages = {S517-S517},
Publisher = {SPRINGER LONDON LTD},
Year = {2014},
Month = {June},
ISSN = {0937-941X},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000348647200016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds316723}
}
@article{fds316722,
Author = {Lunsford, J and Silverman, SL and Gold, DT},
Title = {Reports of Depression in Older Women with
Osteoporosis},
Journal = {American Journal of Geriatric Psychiatry},
Volume = {22},
Number = {3},
Pages = {S69-S70},
Publisher = {Elsevier BV},
Year = {2014},
Month = {March},
ISSN = {1064-7481},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000336081800068&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Doi = {10.1016/j.jagp.2013.12.075},
Key = {fds316722}
}
@article{fds316725,
Author = {Gold, DT and Calderon, A and Silverman, SL},
Title = {THE IMPACT OF HEALTH BELIEFS ON OSTEOPOROSIS
TREATMENT},
Journal = {Osteoporosis International : a Journal Established as Result
of Cooperation Between the European Foundation for
Osteoporosis and the National Osteoporosis Foundation of the
Usa},
Volume = {24},
Pages = {S437-S438},
Publisher = {SPRINGER LONDON LTD},
Year = {2013},
Month = {April},
ISSN = {0937-941X},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000328350000027&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds316725}
}
@article{fds272804,
Author = {Burge, R and Shen, W and Naegeli, AN and Alam, J and Silverman, S and Gold,
DT and Shih, T},
Title = {Use of health-related quality of life measures to predict
health utility in postmenopausal osteoporotic women: results
from the Multiple Outcomes of Raloxifene Evaluation
study.},
Journal = {Health and Quality of Life Outcomes},
Volume = {11},
Number = {1},
Pages = {189-189},
Publisher = {Springer Nature},
Year = {2013},
Month = {January},
ISSN = {0937-941X},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000309259600084&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Abstract = {The aim of this study is to examine the associations between
health utility (HU), health-related quality of life (HRQoL),
and patient characteristics in postmenopausal osteoporotic
(PMO) women. Baseline data from a subsample of 1,245
participants of the Multiple Outcomes of Raloxifene
Evaluation study, a randomized, placebo-controlled,
multinational clinical trial to evaluate the safety and
efficacy of raloxifene, were analyzed. The study cohort
included 694 participants from non-European Union (non-EU)
countries and 551 participants from EU countries. All
participants with complete baseline HU and HRQoL assessments
were included in the following analyses: 1) HU (HUI or
EQ-5D) and HRQoL (QualEFFO or OPAQ and NHP) associations; 2)
HU variability explained by HRQoL domains; and 3) the
percentage of HU variability explained by statistically
significant (p < 0.05) HRQoL domains, after adjusting for
baseline characteristics. Several domains were significantly
associated with HU scores. HU variance was well explained
(41% to 61%) by 4 to 6 (p < 0.05) significant HRQoL domains.
After controlling for baseline characteristics, 48% to 64%
of the HU variance was well explained by 5 to 7 significant
(p < 0.05) HRQoL domains. Additional trend analyses detected
statistically significant decreases in HRQoL and HU scores
with an increased number of vertebral and non-vertebral
fractures. Both disease-targeted and generic HRQoL domains
were well correlated with HU. A large percentage (48% to
64%) of the HU variance was explained by HRQoL, after
adjusting for baseline characteristics. Both
disease-targeted and generic HRQoL measures were significant
predictors of HU. HRQoL and HU scores decreased with
increased vertebral and non-vertebral fractures.},
Doi = {10.1186/1477-7525-11-189},
Key = {fds272804}
}
@article{fds316728,
Author = {Silverman, S and Tosteson, A and Schousboe, J and Nichol, M and Gold,
DT and Borgstrom, F},
Title = {INTERNATIONAL COST AND UTILITIES RELATED TO OSTEOPOROSIS
FRACTURE STUDY IN USA (ICUROS-US); STUDY DESIGN AND
METHODS},
Journal = {Osteoporosis International : a Journal Established as Result
of Cooperation Between the European Foundation for
Osteoporosis and the National Osteoporosis Foundation of the
Usa},
Volume = {20},
Pages = {S219-S219},
Publisher = {SPRINGER LONDON LTD},
Year = {2009},
Month = {April},
ISSN = {0937-941X},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000273012900055&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds316728}
}
@article{fds316727,
Author = {Gold, DT and Bessette, L and Horne, R and Borenstein, J and Varon, SF and Wang, H and Satram-Hoang, S and Wagman, RB and Macarios, D and Bone,
HG},
Title = {PATIENT PREFERENCE AND SATISFACTION WITH A 6-MONTH INJECTION
VERSUS A WEEKLY PILL FOR TREATMENT OF POSTMENOPAUSAL BONE
LOSS},
Journal = {Osteoporosis International : a Journal Established as Result
of Cooperation Between the European Foundation for
Osteoporosis and the National Osteoporosis Foundation of the
Usa},
Volume = {20},
Pages = {S201-S202},
Publisher = {SPRINGER LONDON LTD},
Year = {2009},
Month = {April},
ISSN = {0937-941X},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000273012900023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds316727}
}
@article{fds316720,
Author = {Abelson, A and Thomas, TP and Gold, DT and Lange, JL and Ringe,
JD},
Title = {REAL-WORLD EFFECTIVENESS OF BISPHOSPHONATES FOR THE
REDUCTION OF CLINICAL FRACTURES},
Journal = {Osteoporosis International : a Journal Established as Result
of Cooperation Between the European Foundation for
Osteoporosis and the National Osteoporosis Foundation of the
Usa},
Volume = {20},
Pages = {S218-S219},
Publisher = {SPRINGER LONDON LTD},
Year = {2009},
Month = {April},
ISSN = {0937-941X},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000273012900054&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds316720}
}
@article{fds316721,
Author = {Gold, DT and Safi, W and Trinh, H},
Title = {Monthly ibandronate did not improve patient persistence vs
weekly risedronate: 1 year data},
Journal = {Osteoporosis International : a Journal Established as Result
of Cooperation Between the European Foundation for
Osteoporosis and the National Osteoporosis Foundation of the
Usa},
Volume = {18},
Pages = {S223-S224},
Publisher = {SPRINGER LONDON LTD},
Year = {2007},
Month = {April},
ISSN = {0937-941X},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000245981100059&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds316721}
}
@article{fds272814,
Author = {Gold, DT},
Title = {Medication adherence: a challenge for patients with
postmenopausal osteoporosis and other chronic
illnesses.},
Journal = {Journal of Managed Care Pharmacy : Jmcp},
Volume = {12},
Number = {6 Suppl A},
Pages = {S20-S25},
Year = {2006},
Month = {July},
ISSN = {1083-4087},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000240002300004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Abstract = {OBJECTIVE: To define medication adherence and describe the
limitations of various assessment methods, reasons for
nonadherence to medications used to manage chronic illness,
the impact of nonadherence to osteoporosis medications, and
strategies for improving medication adherence. BACKGROUND:
Medication nonadherence is a major public health problem
that adversely affects patient outcomes and increases health
care utilization and costs. Postmenopausal osteoporosis is a
chronic disease, and adherence to drug therapy used to
manage the disease is as much of a challenge as it is in
other chronic diseases. SUMMARY: Medication adherence
reflects both compliance and persistence. Direct assessment
methods (e.g., observation, laboratory serum drug assays)
are more accurate than indirect methods, but they are more
costly and often impractical. Indirect methods include
patient self-report and the use of prescription refill
records, pill counts, and electronic monitoring devices.
Medication adherence in patients with postmenopausal
osteoporosis or other chronic illnesses is less than
optimal. Adverse effects, financial constraints,
mis-communication with the prescriber, and a perception that
medications are unnecessary are among the possible reasons
for medication nonadherence. Unintentional nonadherence is a
passive process, often simply forgetting, and intentional
nonadherence is an active process involving a deliberate
choice, often based on adverse effects or a perceived lack
of benefit. CONCLUSIONS: Nonadherence to osteoporosis
medications can adversely affect patient outcomes and
increase health care utilization and costs. An
individualized approach to improving medication adherence
based on patient preferences and readiness to change is
needed.},
Doi = {10.18553/jmcp.2006.12.S6-A.S20},
Key = {fds272814}
}
@article{fds39216,
Author = {Gold, D.T.},
Title = {Quality of life and its measurement in osteoporosis},
Pages = {67-69},
Booktitle = {Bone disease in rheumatology},
Publisher = {Philadelphia, PA: Lippincott, Williams &
Wilkins},
Editor = {M. Maricic and O.S. Gluck},
Year = {2005},
Key = {fds39216}
}
@article{fds39178,
Author = {Gold, D.T.},
Title = {Osteoporosis and quality of life: psychosocial outcomes and
interventions for individual patients},
Journal = {Clinics in Geriatric Medicine},
Volume = {19},
Pages = {271-280},
Year = {2003},
Key = {fds39178}
}
@article{fds39179,
Author = {Bonner, F.J. and Sinaki, M. and Grabois, M. and Shipp, K.M. and Lane, J.M. and Lindsay, R. and Gold, D.T. and Cosman, F. and Bouxsein, M.L. and Weinstein, J.N. and Gallagher, R.M. and Melton, L.J. III and Salcido, R. and Gordon, S.l.},
Title = {Health professional's guide to rehabilitation of the patient
with osteoporosis},
Journal = {Osteoporosis International},
Volume = {14, Suppl. 2},
Pages = {S1-S22},
Year = {2003},
Key = {fds39179}
}
@article{fds39176,
Author = {Roberto, K.A. and Gold, D.T.},
Title = {Chronic pain in later life women: Issues and challenges from
the research literature},
Journal = {Journal of the American Medical Women's Association},
Volume = {57},
Pages = {97-99},
Year = {2002},
Key = {fds39176}
}
@article{fds39174,
Author = {Gold, D.T.},
Title = {The non-skeletal consequences of osteoporotic fractures:
Psychological and social outcomes},
Journal = {Rheumatic Disease Clinics of North America},
Volume = {27},
Pages = {255-262},
Year = {2001},
Key = {fds39174}
}
@article{fds39175,
Author = {Mendes de Leon and C.F., Gold and D.T., Glass and T.A., Kaplan and L. and George, L.K.},
Title = {Disability as a function of social networks and support in
elderly African-Americans and whites: the Duke EPESE
1986-1992},
Journal = {Journal of Gerontology: Social Sciences},
Volume = {56B},
Pages = {S179-S190},
Year = {2001},
Key = {fds39175}
}
@article{fds39215,
Author = {Gold, D.T. and Lyles, K.W. and Shipp, K.M. and Drezner,
M.D.},
Title = {Osteoporosis and its nonskeletal conferences: Their impact
on treatment decisions},
Series = {2nd edition},
Pages = {479-484},
Booktitle = {Osteoporosis},
Publisher = {San Diego, CA: Academic Press},
Editor = {R. Marcus and D. Feldman and J. Kelsey},
Year = {2001},
Key = {fds39215}
}
@article{fds39170,
Author = {Hegarty, V. and Burchett, B.M. and Gold, D.T. and Cohen,
H.J.},
Title = {Racial differences in use of cancer prevention services
among older Americans},
Journal = {Journal of the American Geriatrics Society},
Volume = {48},
Pages = {735-740},
Year = {2000},
Key = {fds39170}
}
@article{fds39171,
Author = {Gold, D.T. and Roberto, K.A.},
Title = {Correlates and consequences of chronic pain in older
adults},
Journal = {Geriatric Nursing},
Volume = {21},
Pages = {270-273},
Year = {2000},
Key = {fds39171}
}
@article{fds39172,
Author = {Shipp, K.M. and Purser, J.L. and Gold, D.T. and Pieper, C.F. and Sloane, R. and Schenkman, M. and Lyles, K.W.},
Title = {Timed loaded standing: A measure of combined trunk and arm
endurance suitable for people with vertebral
osteoporosis},
Journal = {Osteoporosis International},
Volume = {11},
Pages = {914-922},
Year = {2000},
Key = {fds39172}
}
@article{fds39173,
Author = {Blalock, S.J. and Currey, S.S. and DeVellis, R.F. and DeVellis, B.M. and Giorgino, K.B. and Anderson, J.J.B. and Dooley, M.A. and Gold,
D.T.},
Title = {Effects of educational materials concerning osteoporosis on
women's knowledge, beliefs, and behavior},
Journal = {American Journal of Health Promotion},
Volume = {14},
Pages = {161-169},
Year = {2000},
Key = {fds39173}
}
@article{fds39165,
Author = {Purser, J.L. and Pieper, C.F. and Duncan, P.W. and Gold, D.T. and McConnell, E.S. and Schenkman, M.S. and Morey, M.C. and Branch,
L.G.},
Title = {Reliability of physical performance tests in four different
randomized clinical trials},
Journal = {Archives of Physical Medicine and Rehabilitation},
Volume = {80},
Pages = {557-561},
Year = {1999},
Key = {fds39165}
}
@article{fds39166,
Author = {Koplas, P.A. and Gans, H.B. and Wisely, M.P. and Kuchibhatla, M. and Cutson, T.M. and Gold, D.T. and Taylor, C.T. and Schenkman,
M.},
Title = {Quality of life and Parkinson's disease},
Journal = {Journals of Gerontology: Medical Sciences},
Volume = {54},
Pages = {M197-M202},
Year = {1999},
Key = {fds39166}
}
@article{fds39168,
Author = {Gold, D.T. and Burchett, B.M. and Shipp, K.M. and Pieper, C.F. and Lyles, K.W.},
Title = {Factors associated with self-rated health in patients with
Paget's disease of bone},
Journal = {Journal of Bone and Mineral Research},
Volume = {14, Suppl. 2},
Pages = {99-102},
Year = {1999},
Key = {fds39168}
}
@article{fds39211,
Author = {Hays, J.C. and Gold, D.T. and Flint, E.P. and Winer,
E.P.},
Title = {Patient preference for place of death: A qualitative
approach},
Pages = {3-21},
Booktitle = {End of life issues: Interdisciplinary and Multidimensional
Perspectives},
Publisher = {New York: Springer},
Editor = {B. de Vries},
Year = {1999},
Key = {fds39211}
}
@article{fds39212,
Author = {Gold, D.T. and Lyles, K.W.},
Title = {Fractures: Effects on quality of life},
Pages = {373-382},
Booktitle = {The aging skeleton},
Publisher = {San Diego, CA: Academic Press},
Editor = {C. Rosen and J. Glowacki and J.P. Bilezikian},
Year = {1999},
Key = {fds39212}
}
@article{fds39213,
Author = {Gold, D.T.},
Title = {Outcomes and the personal impact of osteoporosis},
Pages = {51-63},
Booktitle = {Osteoporosis in men: The effects of gender on skeletal
health},
Publisher = {San Diego, CA: Academic Press},
Editor = {E.S. Orwoll},
Year = {1999},
Key = {fds39213}
}
@article{fds39162,
Author = {Landerman, R.L. and Fillenbaum, G.G. and Pieper, C.F. and Maddox, G.L. and Gold, D.T. and Guralnik, J.},
Title = {Private health insurance coverage and disability among older
Americans},
Journal = {Journals of Gerontology: Social Sciences},
Volume = {53B},
Pages = {S258-S266},
Year = {1998},
Key = {fds39162}
}
@article{fds39163,
Author = {Gold, D.T. and Shipp, K.M. and Lyles, K.W.},
Title = {Managing patients with complications of osteoporosis},
Journal = {Endocrinology & Metabolism Clinics of North
America},
Volume = {27},
Pages = {485-496},
Year = {1998},
Key = {fds39163}
}
@article{fds39160,
Author = {Blazer, D.G. and Hays, J.C. and Fillenbaum, G.G. and Gold,
D.T.},
Title = {Memory complaint as a predictor of cognitive decline: A
comparison of African-American and White
elders},
Journal = {Journal of Aging and Health},
Volume = {9},
Pages = {171-184},
Year = {1997},
Key = {fds39160}
}
@article{fds39161,
Author = {Lyles, K.W. and Gold, D. T. and Newton, R.A. and Parekh, S. and Shipp, K.M. and Pieper, C.F. and Krishan, R. and Carson, CC
III},
Title = {Peyronie's disease is associated with Paget's disease of
bone},
Journal = {Journal of Bone and Mineral Research},
Volume = {12},
Pages = {929-934},
Year = {1997},
Key = {fds39161}
}
@article{fds39049,
Author = {Gold DT and Boisture J and Shipp KM and Pieper CF and Lyles
KW},
Title = {Paget's disease of bone and quality of life},
Journal = {Journal of Bone and Mineral Research},
Volume = {11},
Pages = {1897-1903},
Year = {1996},
Key = {fds39049}
}
@article{fds39050,
Author = {Gold DT and Pieper CF and Westlund RE and Blazer
DG},
Title = {Do racial differences in hypertension persist in successful
agers? Findings from the MacArthur Study of Successful
Aging},
Journal = {Journal of Aging and Health},
Volume = {8},
Pages = {207-219},
Year = {1996},
Key = {fds39050}
}
@article{fds39152,
Author = {Hays, J.C. and Schoenfeld, D. and Blazer, D.G. and Gold,
D.T.},
Title = {Global self-ratings of health and mortality: Hazard in the
North Carolina Piedmont},
Journal = {Journal of Clinical Epidemiology},
Volume = {49},
Pages = {969-979},
Year = {1996},
Key = {fds39152}
}
@article{fds39207,
Author = {Gold, D.T.},
Title = {Continuities and discontinuities in sibling relationships
across the life span},
Pages = {228-243},
Booktitle = {Adulthood and aging: Research on continuities and
discontinuities},
Publisher = {New York: Springer},
Editor = {V.L. Bengtson},
Year = {1996},
Key = {fds39207}
}
@article{fds39208,
Author = {Gold, D.T. and Lyles, K.W. and Shipp, K.M. and Harper, K.D. and Drezner, M.K.},
Title = {Unexpected consequences of osteoporosis: An evolving basis
for treatment decisions},
Pages = {1089-1096},
Booktitle = {Osteoporosis},
Publisher = {San Diego, CA: Academic Press},
Editor = {R. Marcus and D. Feldman and J. Kelsey},
Year = {1996},
Key = {fds39208}
}
@article{fds39148,
Author = {Lyles, K.W. and Lammers, J.E. and Shipp, K.M. and Sherman, L. and Pieper, C.F. and Gold, D.T.},
Title = {Functional and mobility impairments associated with Paget's
Disease of Bone},
Journal = {Journal of the American Geriatrics Society},
Volume = {43},
Pages = {502-506},
Year = {1995},
Key = {fds39148}
}
@article{fds39149,
Author = {Hays, J.C. and Fillenbaum, G.G. and Gold, D.T. and Shanley, M.C. and Blazer, D.G.},
Title = {Black-white and urban-rural differences in stability of
household composition among the elderly},
Journal = {Journal of Gerontology: Social Sciences},
Volume = {50B},
Pages = {S301-S311},
Year = {1995},
Key = {fds39149}
}
@article{fds39206,
Author = {Gold, D.T. and Drezner, M.K.},
Title = {Osteoporosis and quality of life: Impact on delivery of
care},
Series = {2nd edition},
Pages = {475-486},
Booktitle = {Osteoporosis: Etiology, diagnosis, and management},
Publisher = {Philadelphia, PA: Lippincott-Raven Publishers},
Editor = {B.L. Riggs and L.J. Melton III},
Year = {1995},
Key = {fds39206}
}
@article{fds39145,
Author = {Schoenfeld, D.E. and Malmrose, L.C. and Blazer, D.G. and Gold, D.T. and Seeman, T.E.},
Title = {Self-rated health and mortality in the high-functioning
elderly--a closer look at healthy individuals: MacArthur
Field Study of Successful Aging},
Journal = {Journals of Gerontology: Medical Sciences},
Volume = {49},
Pages = {M109-M115},
Year = {1994},
Key = {fds39145}
}
@article{fds39146,
Author = {Linzer, M. and Gold, D.T. and Pontinen, M. and Divine, G.W. and Felder, A. and Brooks, W.B.},
Title = {Recurrent syncope as a chronic disease: Preliminary
validation of a disease-specific measure of functional
impairment},
Journal = {Journal of General Internal Medicine},
Volume = {9},
Pages = {181-186},
Year = {1994},
Key = {fds39146}
}
@article{fds39204,
Author = {Gold, D.T.},
Title = {Social support in later life},
Pages = {359-370},
Booktitle = {Older Americans Almanac},
Publisher = {Detroit, MI: Gale Research Inc},
Editor = {R.J. Manheimer},
Year = {1994},
Key = {fds39204}
}
@article{fds39205,
Author = {Gold, D.T.},
Title = {Family relationships in later life},
Pages = {319-342},
Booktitle = {Older Americans Almanac},
Publisher = {Detroit, MI: Gale Research Inc},
Editor = {R.J. Manheimer},
Year = {1994},
Key = {fds39205}
}
@article{fds39143,
Author = {Weinberger, M. and Gold, D.T. and Divine, G.W. and Cowper, P.A. and Hodgson, L.G. and Schreiner, P.J. and George,
L.K.},
Title = {Social service interventions for caregivers of patients with
dementia: Impact on health care utilization and
expenditures},
Journal = {Journal of the American Geriatrics Society},
Volume = {41},
Pages = {153-156},
Year = {1993},
Key = {fds39143}
}
@article{fds39144,
Author = {Lyles, K.W. and Gold, D.T. and Shipp, K.M. and Pieper, C.F. and Martinez, S. and Mulhausen, P.L.},
Title = {Association of osteoporotic vertebral compression fractures
with impaired functional status},
Journal = {American Journal of Medicine},
Volume = {94},
Pages = {595-601},
Year = {1993},
Key = {fds39144}
}
@article{fds39198,
Author = {Gold, D.T. and Schmader, K.},
Title = {An introduction to aging},
Series = {Revised edition},
Pages = {1-18},
Booktitle = {Psychiatry},
Publisher = {Philadelphia, PA: J.B. Lippencott Company},
Editor = {R. Michaels},
Year = {1993},
Key = {fds39198}
}
@article{fds39141,
Author = {Weinberger, M. and Saunders, A.F. and Bearon, L.B. and Gold, D.T. and Brown, J.T. and Samsa, G.P. and Loehrer, P.J.},
Title = {Physician-related barriers to breast cancer screening in
older women},
Journal = {Journal of Gerontology},
Volume = {47},
Pages = {111-117},
Year = {1992},
Key = {fds39141}
}
@article{fds39136,
Author = {Weinberger, M. and Saunders, A.F. and Samsa, G.P. and Bearon, L.B. and Gold, D.T. and Brown, J.T. and Booher, P. and Loehrer,
P.J.},
Title = {Breast cancer screening in older women: Practices and
barriers reported by primary care physicians},
Journal = {Journal of the American Geriatrics Society},
Volume = {39},
Pages = {22-29},
Year = {1991},
Key = {fds39136}
}
@article{fds39138,
Author = {Gold, D.T. and Smith, S.D. and Bales, C.W. and Lyles, K.W. and Westlund, R.E. and Drezner, M.K.},
Title = {Osteoporosis in late life: Does health locus of control
affect psychosocial adaptation?},
Journal = {Journal of the American Geriatrics Society},
Volume = {39},
Pages = {670-675},
Year = {1991},
Key = {fds39138}
}
@article{fds39139,
Author = {Gold, D.T. and Sloane, P.D. and Mathew, L.J. and Bledsoe, M.M. and Konanc, D.A.},
Title = {Special care units: A typology of care settings for
memory-impaired older adults},
Journal = {The Gerontologist},
Volume = {31},
Pages = {467-475},
Year = {1991},
Key = {fds39139}
}
@article{fds39196,
Author = {Gold, D.T.},
Title = {A descriptive typology of dementia units},
Pages = {50-61},
Booktitle = {Dementia units in long-term care},
Publisher = {Baltimore, MD: The Johns Hopkins University
Press},
Editor = {P.D. Sloane and L.J. Mathew},
Year = {1991},
Key = {fds39196}
}
@article{fds39053,
Author = {Gold, D.T. and Woodbury, M.A. and George, L.K.},
Title = {Relationship classification using Grade of Membership (GOM)
analysis: A typology of sibling relationships in later
life},
Journal = {Journal of Gerontology},
Volume = {45},
Pages = {S43-S51},
Year = {1990},
Key = {fds39053}
}
@article{fds39133,
Author = {Gold, D.T.},
Title = {Late-life sibling relationships: Does race affect
typological distribution?},
Journal = {The Gerontologist},
Volume = {30},
Pages = {741-748},
Year = {1990},
Key = {fds39133}
}
@article{fds39235,
Title = {Siblings in late life: A neglected family
relationship},
Journal = {American Behavioral Scientist},
Volume = {33},
Series = {Special Edition},
Editor = {V.H. Bedford and D.T. Gold},
Year = {1989},
Month = {September},
Key = {fds39235}
}
@article{fds39128,
Author = {Gold, D.T.},
Title = {Sibling relations in old age: A typology},
Journal = {The International Journal of Aging and Human
Development},
Volume = {28},
Pages = {37-51},
Year = {1989},
Key = {fds39128}
}
@article{fds39130,
Author = {Gold, D.T. and Bales, C.W. and Lyles, K.W. and Drezner,
M.K.},
Title = {Treatment of osteoporosis: The psychological impact of a
medical education program on older patients},
Journal = {Journal of the American Geriatrics Society},
Volume = {37},
Pages = {417-422},
Year = {1989},
Key = {fds39130}
}
@article{fds39131,
Author = {Gold, D.T. and Lyles, K.W. and Bales, C.W. and Drezner,
M.K.},
Title = {Teaching patients coping behaviors: An essential part of
successful management of osteoporosis},
Journal = {Journal of Bone and Mineral Research},
Volume = {4},
Pages = {799-801},
Year = {1989},
Key = {fds39131}
}
@article{fds39193,
Author = {Bales, C.W. and Gold, D.T. and Lyles, K.W. and Drezner,
M.K.},
Title = {Osteoporosis: A multidisciplinary program of prevention and
therapy},
Pages = {251-256},
Booktitle = {Mineral homeostasis in the elderly},
Publisher = {New York: Alan R. Liss, Inc.},
Editor = {C.W. Bales},
Year = {1989},
Key = {fds39193}
}
@article{fds39194,
Author = {George, L.K. and Gold, D.T.},
Title = {Job loss in middle age},
Pages = {249-280},
Booktitle = {Coping with the losses of middle age},
Publisher = {Beverly Hills, CA: Sage Publications},
Editor = {R. Kalish},
Year = {1989},
Key = {fds39194}
}
%% Papers Published
@article{fds363002,
Author = {Beaudart, C and Silverman, S and Gold, DT and Williams, SA and Weiss, R and Hiligsmann, M},
Title = {A Qualitative Study to Assess US Patient Preferences between
new Transdermal System and Injectable Anabolic Therapies for
Osteoporosis Treatment.},
Journal = {Arch Osteoporos},
Volume = {17},
Number = {1},
Pages = {57},
Year = {2022},
Month = {April},
url = {http://dx.doi.org/10.1007/s11657-022-01075-z},
Abstract = {UNLABELLED: US patients with osteoporosis included in three
focus groups identified efficacy, safety, cost, and
convenience as important attributes of treatment when
choosing between anabolic therapies with high stated
preference for the solid Microstructured Transdermal System.
OBJECTIVE: The current study evaluated patient perspective
and relative importance of treatment attributes of in-home
daily self-administration of abaloparatide-solid
Microstructured Transdermal System (sMTS) compared with
other anabolic agents (i.e. in-home daily subcutaneous
self-injections, and monthly subcutaneous injections at
doctor office) among a group of US patients with
osteoporosis. METHODS: The current study included systematic
literature reviews, experts' consultation and three online
patients focus groups (n=27), including patients ≥50 years
of age at high risk for fracture. Nominal Group Technique
was used by asking patients to (1) Individually identify
characteristics that would be important for them when
choosing between anabolic treatments, (2) Share ideas and
discuss perspectives with other patients, (3) Review
additional attributes generated from a systematic literature
review, (4) Select and rank individually the 7 most
important characteristics from the list and (5) Report their
acceptability and stated preference ranking between the
three treatment options. RESULTS: Twenty women and 7 men
with a mean age of 65 (range 51-85 years) participated in
the focus groups. Twenty-four treatment characteristics were
identified through focus groups and literature review.
Efficacy, safety, out-of-pocket costs, strength of evidence
and the option to self-administer were ranked as the most
important attributes. The majority of patients stated
preference for a daily sMTS if prescribed by their doctor.
CONCLUSIONS: This study revealed that efficacy, safety,
costs, and convenience are important attributes of
osteoporosis treatment for US patients at high risk for
fractures when choosing between anabolic therapies, with a
high stated preference for sMTS.},
Doi = {10.1007/s11657-022-01075-z},
Key = {fds363002}
}
@article{fds362839,
Author = {Alexopoulos, EA and Guinee, EP and Stewart, KA and Brown, CS and Gold,
DT and Engle, D and Talenti, F and Klevansky, R and Barfield, R and Ross,
E and Prose, NS},
Title = {Keepers of the House: A documentary.},
Journal = {Clin Teach},
Volume = {19},
Number = {1},
Pages = {36-41},
Year = {2022},
Month = {February},
url = {http://dx.doi.org/10.1111/tct.13439},
Abstract = {BACKGROUND: Our documentary, Keepers of the House,
highlights ways that hospital housekeepers, typically
unnoticed care team members, provide emotional support for
patients and their families. This film addresses a gap in
education by emphasizing the importance of valuing and
reflecting on the unique lived experiences of others.
APPROACH: We created this documentary to expose students to
the experiences and perceptions of hospital housekeepers. A
focus group with six hospital housekeepers informed an
interview script for the film's creation. Nine additional
housekeepers were then interviewed, which developed into a
15-min documentary. Healthcare students and educators from
five disciplines viewed the documentary during their
institution's Medical Education Day. EVALUATION: To expose
students and educators to housekeepers' experiences, we
designed our post-viewing survey to address whether the
housekeepers' stories impacted their understanding of the
role and value of these workers. Viewers were surprised by
the depth and breadth of patient-housekeeper interactions,
the trauma housekeepers experienced from patient loss and
the pride housekeepers take in their work. The stories that
touched the viewers varied but centred on connections
between housekeepers and patients. Lessons learned focused
on recognizing the contributions of unseen team members.
IMPLICATIONS: This innovative documentary amplifies the
perspectives of voices rarely heard in healthcare. We aim to
use this film, alongside its associated learning session, in
education and grand round settings to foster discussion
around empathy, valuing underrecognised team members and
applying these insights in practice. This work can be
disseminated to other institutions, further amplifying
underrepresented narratives in healthcare.},
Doi = {10.1111/tct.13439},
Key = {fds362839}
}
@article{fds358051,
Author = {Gold, DT and Weiss, R and Beckett, T and Deal, C and Epstein, RS and James,
AL and Kernaghan, JM and Mohseni, M and Spiegel, M and Vokes, T and Roberts, J and Bailey, T and Wang, Y and Williams,
SA},
Title = {Abaloparatide Real-World Patient Experience
Study.},
Journal = {Jbmr Plus},
Volume = {5},
Number = {3},
Pages = {e10457},
Year = {2021},
Month = {March},
url = {http://dx.doi.org/10.1002/jbm4.10457},
Abstract = {Despite the availability of various osteoporosis treatments,
adherence remains suboptimal. One contributing factor may be
patient experience with therapy. This US, multicenter,
combined retrospective chart review and patient
questionnaire study included postmenopausal women at high
risk for fracture and is the first study to describe
real-world patient experience with abaloparatide (ABL)
injection. Eight geographically diverse secondary care sites
in the United States participated (n = 193). Mean ± SD age
was 67.4 ±8.62 years. Most patients (86%) were satisfied
with the ABL regimen, especially with ease of preparation
(82%), ease of storage (87%), and storage convenience (89%),
an attribute 83% of the patients thought was important. The
majority of patients reported complete satisfaction with the
ABL regimen allowing for their ability to conduct daily
activities (85%) and convenience to fit into their daily
schedule (84%). All reported taking ABL as directed, by
injection in the lower abdomen, and 83% of patients reported
medium or high adherence. Patients were satisfied with the
needle size (76% completely satisfied), and 93% reported
never deliberately missing a dose. Although injecting
medication (18%) and higher out-of-pocket costs (17%) were
deemed the most bothersome attributes, the majority (69%)
noted their healthcare team understands how osteoporosis
impacts their lives. In multivariable analyses, ease of
preparation (OR = 2.62; 95% CI, 1.01-6.81; p = 0.048) and
fracture history (OR = 1.72; 95% CI, 1.03-2.86; p = 0.037)
were significantly associated with overall satisfaction.
Ease of preparation was a predictor of higher satisfaction
with treatment convenience (coefficient = 13.60; 95% CI,
8.08-19.12; p = 0.00). Remembering to take the medication
was a significant predictor of self-reported adherence (OR =
16.66; 95% CI, 3.30-84.24; p = 0.001). In conclusion, the
majority of patients were satisfied with ABL and found it
convenient/easy to prepare and store. High self-reported
adherence may be associated with positive patient experience
including ease of use and adequate support from healthcare
providers. © 2020 The Authors. JBMR Plus published by Wiley
Periodicals LLC. on behalf of American Society for Bone and
Mineral Research.},
Doi = {10.1002/jbm4.10457},
Key = {fds358051}
}
@article{fds352907,
Author = {Nwosu, C and Spears, CA and Pate, C and Gold, DT and Bennett, G and Haglund, M and Fuller, A},
Title = {Influence of Caretakers' Health Literacy on Delays to
Traumatic Brain Injury Care in Uganda.},
Journal = {Annals of Global Health},
Volume = {86},
Number = {1},
Pages = {127},
Year = {2020},
Month = {October},
url = {http://dx.doi.org/10.5334/aogh.2978},
Abstract = {BACKGROUND: Traumatic brain injury (TBI) is a life-altering
condition, and delays to care can significantly impact
outcomes. In Uganda, where nurse shortages are prevalent,
patients' family members are the primary caretakers of these
patients and play an important role in ensuring patients'
access to timely care. However, caretakers often have little
or no knowledge of appropriate patient care. Caretakers'
ability to navigate the healthcare system and find and use
health information to support their patients can impact
delays in seeking, reaching, and receiving care. OBJECTIVES:
This study seeks to determine the factors that impact TBI
patient caretakers' health literacy and examine how these
factors influence delays in care. METHODS: This study was
carried out in the Mulago National Referral Hospital
neurosurgical ward, where 27 adult caretakers were
interviewed using semi-structured, in-depth, qualitative
interviews. "The Three Delay Framework" was utilized to
understand participants' experiences in seeking, reaching,
and receiving care for TBI patients. Thematic content
analysis and manual coding was used to analyze interview
transcripts and identify overarching themes in participant
responses. FINDINGS: The main health literacy themes
identified were Extrinsic, Intrinsic and Health System
Factors. Nine sub-themes were identified: Government
Support, Community Support, Financial Burdens, Lack of
Medical Resources, Access to Health Information, Physician
Support, Emotional Challenges, Navigational Skills, and
Understanding of Health Information. These components were
found to influence the delays to care to varying degrees.
Financial Burdens, Government Support, Emotional Challenges,
Physician Support and Lack of Medical Resources were
recurring factors across the three delays. CONCLUSION: The
health literacy factors identified in this study influence
caretakers' functional health literacy and delays to care in
a co-dependent manner. A better understanding of how these
factors impact patient outcomes is necessary for the
development of interventions targeted at improving a
caretaker's ability to maneuver the healthcare system and
support patients in resource-poor settings.},
Doi = {10.5334/aogh.2978},
Key = {fds352907}
}
@article{fds272859,
Author = {Hays, JC and Gold, DT and Pieper, CF},
Title = {Sibling bereavement in late life},
Volume = {35},
Number = {1},
Pages = {25-42},
Publisher = {SAGE Publications},
Year = {2019},
Month = {January},
ISSN = {0030-2228},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997XX73900003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Abstract = {Elders are more likely to confront the death of a sibling
than any other kinship bereavement. Yet we know almost
nothing about the impact of sibling deaths on older adults.
We used attachment theory to generate hypotheses about the
impact of this life event on physical health, mood, social
support, and economic outcomes in late life. At the Duke
University site of a large multi-center epidemiologic study
(EPESE), 3173 elderly community-dwellers provided data on
bereavements experienced in the past year as well as on
demographic, health-related, and socioeconomic
characteristics. Bereaved siblings were more functionally
and cognitively impaired than bereaved friends and rated
their overall health as worse than bereaved spouses or
bereaved friends who were similarly impaired. Brothers and
sisters bereaved of a brother reported excess financial
hardship and mood impairment, respectively. Terminal care
programs should screen for excess risk among surviving
siblings and plan for assisting these survivors in
adaptation to this loss.},
Doi = {10.2190/ye89-2gu8-c8u3-mrnx},
Key = {fds272859}
}
@article{fds341555,
Author = {Hiligsmann, M and Reginster, J-Y and Tosteson, ANA and Bukata, SV and Saag, KG and Gold, DT and Halbout, P and Jiwa, F and Lewiecki, EM and Pinto, D and Adachi, JD and Al-Daghri, N and Bruyère, O and Chandran,
M and Cooper, C and Harvey, NC and Einhorn, TA and Kanis, JA and Kendler,
DL and Messina, OD and Rizzoli, R and Si, L and Silverman,
S},
Title = {Recommendations for the conduct of economic evaluations in
osteoporosis: outcomes of an experts' consensus meeting
organized by the European Society for Clinical and Economic
Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal
Diseases (ESCEO) and the US branch of the International
Osteoporosis Foundation.},
Journal = {Osteoporos Int},
Volume = {30},
Number = {1},
Pages = {45-57},
Year = {2019},
Month = {January},
url = {http://dx.doi.org/10.1007/s00198-018-4744-x},
Abstract = {UNLABELLED: Economic evaluations are increasingly used to
assess the value of health interventions, but variable
quality and heterogeneity limit the use of these evaluations
by decision-makers. These recommendations provide guidance
for the design, conduct, and reporting of economic
evaluations in osteoporosis to improve their transparency,
comparability, and methodologic standards. INTRODUCTION:
This paper aims to provide recommendations for the conduct
of economic evaluations in osteoporosis in order to improve
their transparency, comparability, and methodologic
standards. METHODS: A working group was convened by the
European Society for Clinical and Economic Aspects of
Osteoporosis and Osteoarthritis to make recommendations for
the design, conduct, and reporting of economic evaluations
in osteoporosis, to define an osteoporosis-specific
reference case to serve a minimum standard for all economic
analyses in osteoporosis, to discuss methodologic challenges
and initiate a call for research. A literature review, a
face-to-face meeting in New York City (including 11
experts), and a review/approval by a larger group of experts
worldwide (including 23 experts in total) were conducted.
RESULTS: Recommendations on the type of economic evaluation,
methods for economic evaluation, modeling aspects, base-case
analysis and population, excess mortality, fracture costs
and disutility, treatment characteristics, and model
validation were provided. Recommendations for reporting
economic evaluations in osteoporosis were also made and an
osteoporosis-specific checklist was designed that includes
items to report when performing an economic evaluation in
osteoporosis. Further, 12 minimum criteria for economic
evaluations in osteoporosis were identified and 12
methodologic challenges and need for further research were
discussed. CONCLUSION: While the working group acknowledges
challenges and the need for further research, these
recommendations are intended to supplement general and
national guidelines for economic evaluations, improve
transparency, quality, and comparability of economic
evaluations in osteoporosis, and maintain methodologic
standards to increase their use by decision-makers.},
Doi = {10.1007/s00198-018-4744-x},
Key = {fds341555}
}
@article{fds352910,
Author = {Gold, T and Williams, SA and Weiss, RJ and Wang, Y and Watkins, C and Carroll, J and Middleton, C and Silverman, S},
Title = {Impact of fractures on quality of life in patients with
osteoporosis: a US cross-sectional survey.},
Journal = {Journal of Drug Assessment},
Volume = {8},
Number = {1},
Pages = {175-183},
Year = {2019},
url = {http://dx.doi.org/10.1080/21556660.2019.1677674},
Abstract = {Objective: To evaluate the impact of osteoporosis-related
fractures on health-related quality of life (HRQoL).
Methods: Data were obtained from the 2016 Adelphi US
Osteoporosis Disease Specific Programme™, a
cross-sectional survey of physicians and their male and
female patients with osteoporosis. Patient-reported outcomes
(PRO) measures included the European Quality of Life 5
Domains (EQ-5D), European Quality of Life Visual Analog
Scale (EQ-VAS), and Osteoporosis Assessment Questionnaire
short-version (OPAQ-SV; physical, emotional, and symptom
domains). Associations between PRO scores and the number and
site of fractures were evaluated using ANOVA. Multivariate
analyses were conducted using linear regression. Results:
Physicians provided records for 1848 patients with
osteoporosis. Of these, 981 (53.1%) completed the patient
survey, data for the number of fractures were available for
935/981 (95.3%), and 185/935 (19.8%) had a history of
fracture. Experiencing fractures significantly influenced
scores on all PRO measures (p < .0001). Hip and spine
fractures were associated with the greatest reduction in
most PRO scores. The number of fractures, age, body mass
index, and Charlson Comorbidity Index (CCI) were
significantly associated with PRO measures (p < .05) in
multivariate analyses. In patients with a fracture, fracture
site, CCI, gender (EQ-5D and EQ-VAS), and age (OPAQ-SV
physical only) were significantly associated with PRO
measures. Conclusions: In patients with osteoporosis,
fractures are associated with lower HRQoL and lower overall
health status. Fracture history, fracture site, age, and
comorbidity burden significantly influence HRQoL in
individuals with osteoporosis. These data suggest the need
for interventions to reduce the risk of fractures in
patients with osteoporosis.},
Doi = {10.1080/21556660.2019.1677674},
Key = {fds352910}
}
@article{fds341556,
Author = {Silverman, S and Gold, DT},
Title = {Medication Decision-making in Osteoporosis: Can We Explain
Why Patients Do Not Take Their Osteoporosis
Medications?},
Journal = {Curr Osteoporos Rep},
Volume = {16},
Number = {6},
Pages = {772-774},
Year = {2018},
Month = {December},
url = {http://dx.doi.org/10.1007/s11914-018-0494-0},
Abstract = {Patients at high risk of fracture often do not take
medication for osteoporosis. Recent literature may give us
some insights into why patients at high risk of fracture do
not take medications for osteoporosis.},
Doi = {10.1007/s11914-018-0494-0},
Key = {fds341556}
}
@article{fds337474,
Author = {Silverman, SL and Siris, E and Belazi, D and Recknor, C and Papaioannou,
A and Brown, JP and Gold, DT and Lewiecki, EM and Quinn, G and Balasubramanian, A and Yue, S and Stolshek, B and Kendler,
DL},
Title = {Persistence at 24 months with denosumab among
postmenopausal women with osteoporosis: results of a
prospective cohort study.},
Journal = {Arch Osteoporos},
Volume = {13},
Number = {1},
Pages = {85},
Year = {2018},
Month = {August},
url = {http://dx.doi.org/10.1007/s11657-018-0491-z},
Abstract = {UNLABELLED: Persistence with prescribed medications for
chronic diseases is important; however, persistence with
osteoporosis treatments is historically poor. In this
prospective cohort study of postmenopausal women treated for
osteoporosis in real-world clinical practice settings in the
USA and Canada, 24-month persistence with denosumab was 58%.
PURPOSE: Patients who persist with their prescribed
osteoporosis treatment have increased bone mineral density
(BMD) and reduced risk of fracture. Twelve-month persistence
with denosumab in routine clinical practice is as high as
95%, but there are limited data on longer-term persistence
with denosumab in this setting. METHODS: This single-arm,
prospective, cohort study evaluated 24-month persistence
with denosumab administered every 6 months in
postmenopausal women receiving treatment for osteoporosis in
real-world clinical practice in the USA and Canada.
Endpoints and analyses included the percentage of patients
who persist with denosumab at 24 months (greater than or
equal to four injections with a gap between injections of no
more than 6 months plus 8 weeks), the total number of
injections received by each patient, changes in BMD in
persistent patients, and the incidence of serious adverse
events (SAEs) and fractures. RESULTS: Among 935 enrolled
patients, 24-month persistence was 58% (50% in US patients
and 75% in Canadian patients). A majority of patients
received at least four injections over the observation
period (62% of US patients and 81% of Canadian patients).
Among patients who were persistent at 24 months and who had
a baseline, 12-month, and 24-month DXA scan, mean BMD
increased from baseline to 24 months by 7.8% at the lumbar
spine and 2.1% at the femoral neck. SAEs and fractures were
reported for 122 (13.0%) patients and 54 (5.8%) patients,
respectively. CONCLUSIONS: Persistence with denosumab for
24 months yields improvement in BMD among postmenopausal
women with osteoporosis treated in routine clinical practice
in the USA and Canada.},
Doi = {10.1007/s11657-018-0491-z},
Key = {fds337474}
}
@article{fds326232,
Author = {Kerr, C and Bottomley, C and Shingler, S and Giangregorio, L and de
Freitas, HM and Patel, C and Randall, S and Gold,
DT},
Title = {The importance of physical function to people with
osteoporosis.},
Journal = {Osteoporos Int},
Volume = {28},
Number = {5},
Pages = {1597-1607},
Year = {2017},
Month = {May},
url = {http://dx.doi.org/10.1007/s00198-017-3911-9},
Abstract = {UNLABELLED: There is increasing need to understand patient
outcomes in osteoporosis. This article discusses that
fracture in osteoporosis can lead to a cycle of impairment,
driven by complex psychosocial factors, having a profound
impact on physical function/activity which accumulates over
time. More information is required on how treatments impact
physical function. INTRODUCTION: There is increasing need to
understand patient-centred outcomes in osteoporosis (OP)
clinical research and management. This multi-method paper
provides insight on the effect of OP on patients' physical
function and everyday activity. METHODS: Data were collected
from three sources: (1) targeted literature review on OP and
physical function, conducted in MEDLINE, Embase and
PsycINFO; (2) secondary thematic analysis of transcripts
from patient interviews, conducted to develop a
patient-reported outcome instrument. Transcripts were
re-coded to focus on OP impact on daily activities and
physical function for those with and without fracture
history; and (3) discussions of the literature review and
secondary qualitative analysis results with three clinical
experts to review and interpret the importance and
implications of the findings. RESULTS: Results suggest that
OP, particularly with fracture, can have profound impacts on
physical function/activity. These impacts accumulate over
time through a cycle of impairment, as fracture leads to
longer term detriments in physical function, including loss
of muscle, activity avoidance and reduced physical capacity,
which in turn leads to greater risk of fracture and
potential for further physical restrictions. The cycle of
impairment is complex, as other physical, psychosocial and
treatment-related factors, such as comorbidities, fears and
beliefs about physical activity and fracture risk influence
physical function and everyday activity. CONCLUSION: More
information on how treatments impact physical function would
benefit healthcare professionals and persons with OP in
making treatment decisions and improving treatment
compliance/persistence, as these impacts may be more salient
to patients than fracture incidence.},
Doi = {10.1007/s00198-017-3911-9},
Key = {fds326232}
}
@article{fds326233,
Author = {Diez-Perez, A and Naylor, KE and Abrahamsen, B and Agnusdei, D and Brandi, ML and Cooper, C and Dennison, E and Eriksen, EF and Gold, DT and Guañabens, N and Hadji, P and Hiligsmann, M and Horne, R and Josse, R and Kanis, JA and Obermayer-Pietsch, B and Prieto-Alhambra, D and Reginster, J-Y and Rizzoli, R and Silverman, S and Zillikens, MC and Eastell, R and Adherence Working Group of the International
Osteoporosis Foundation and the European Calcified Tissue
Society},
Title = {International Osteoporosis Foundation and European Calcified
Tissue Society Working Group. Recommendations for the
screening of adherence to oral bisphosphonates.},
Journal = {Osteoporos Int},
Volume = {28},
Number = {3},
Pages = {767-774},
Year = {2017},
Month = {March},
url = {http://dx.doi.org/10.1007/s00198-017-3906-6},
Abstract = {UNLABELLED: Adherence to oral bisphosphonates is low. A
screening strategy is proposed based on the response of
biochemical markers of bone turnover after 3 months of
therapy. If no change is observed, the clinician should
reassess the adherence to the treatment and also other
potential issues with the drug. INTRODUCTION: Low adherence
to oral bisphosphonates is a common problem that jeopardizes
the efficacy of treatment of osteoporosis. No clear
screening strategy for the assessment of compliance is
widely accepted in these patients. METHODS: The
International Osteoporosis Foundation and the European
Calcified Tissue Society have convened a working group to
propose a screening strategy to detect a lack of adherence
to these drugs. The question to answer was whether the bone
turnover markers (BTMs) PINP and CTX can be used to identify
low adherence in patients with postmenopausal osteoporosis
initiating oral bisphosphonates for osteoporosis. The
findings of the TRIO study specifically address this
question and were used as the basis for testing the
hypothesis. RESULTS: Based on the findings of the TRIO
study, specifically addressing this question, the working
group recommends measuring PINP and CTX at baseline and
3 months after starting therapy to check for a decrease
above the least significant change (decrease of more than
38% for PINP and 56% for CTX). Detection rate for the
measurement of PINP is 84%, for CTX 87% and, if variation in
at least one is considered when measuring both, the level of
detection is 94.5%. CONCLUSIONS: If a significant decrease
is observed, the treatment can continue, but if no decrease
occurs, the clinician should reassess to identify problems
with the treatment, mainly low adherence.},
Doi = {10.1007/s00198-017-3906-6},
Key = {fds326233}
}
@article{fds326234,
Author = {Eastell, R and O'Neill, TW and Hofbauer, LC and Langdahl, B and Reid,
IR and Gold, DT and Cummings, SR},
Title = {Postmenopausal osteoporosis.},
Journal = {Nature Reviews. Disease Primers},
Volume = {2},
Pages = {16069},
Year = {2016},
Month = {September},
url = {http://dx.doi.org/10.1038/nrdp.2016.69},
Abstract = {Osteoporosis is a metabolic bone disorder that is
characterized by low bone mass and micro-architectural
deterioration of bone tissue. Fractures of the proximal
femur, the vertebrae and the distal radius are the most
frequent osteoporotic fractures, although most fractures in
the elderly are probably at least partly related to bone
fragility. The incidence of fractures varies greatly by
country, but on average up to 50% of women >50 years of age
are at risk of fractures. Fractures severely affect the
quality of life of an individual and are becoming a major
public health problem owing to the ageing population.
Postmenopausal osteoporosis, resulting from oestrogen
deficiency, is the most common type of osteoporosis.
Oestrogen deficiency results in an increase in bone turnover
owing to effects on all types of bone cells. The imbalance
in bone formation and resorption has effects on trabecular
bone (loss of connectivity) and cortical bone (cortical
thinning and porosity). Osteoporosis is diagnosed using bone
density measurements of the lumbar spine and proximal femur.
Preventive strategies to improve bone health include diet,
exercise and abstaining from smoking. Fractures may be
prevented by reducing falls in high-risk populations.
Several drugs are licensed to reduce fracture risk by
slowing down bone resorption (such as bisphosphonates and
denosumab) or by stimulating bone formation (such as
teriparatide). Improved understanding of the cellular basis
for osteoporosis has resulted in new drugs targeted to key
pathways, which are under development.},
Doi = {10.1038/nrdp.2016.69},
Key = {fds326234}
}
@article{fds292779,
Author = {Modi, A and Gold, DT and Yang, X and Fan, C-PS and Sajjan,
SG},
Title = {Association Between Gastrointestinal Events and Health Care
Resource Utilization Among Patients with Osteoporosis:
Analysis of a U.S. Managed Care Population.},
Journal = {J Manag Care Spec Pharm},
Volume = {21},
Number = {9},
Pages = {811-821},
Year = {2015},
Month = {September},
ISSN = {2376-0540},
url = {http://dx.doi.org/10.18553/jmcp.2015.21.9.811},
Abstract = {BACKGROUND: Among patients on osteoporosis therapy,
including oral bisphosphonates (BIS), upper gastrointestinal
(GI) conditions have been linked with lower adherence to
treatment and increased treatment discontinuation in
clinical practice. Patients who are nonadherent to treatment
have a higher risk of osteoporotic fractures and,
consequently, have greater use of health care services. The
burden of upper gastrointestinal events on health care
resource utilization (HCRU) among women initiating oral BIS
has not been well investigated. OBJECTIVE: To examine the
association of upper GI events and HCRU in women initiating
oral BIS. METHODS: Using a U.S. national claims database,
this retrospective study identified women aged ≥ 55
years who were prescribed oral BIS during 2001-2011 and had
no history of GI events 12 months prior to treatment
initiation. Patients with medical claims for an upper GI
event ≤ 4 months posttreatment initiation were cases;
all others were controls. The date of the first upper GI
event among cases and a randomly assigned date ≤ 4
months posttreatment initiation among controls was the index
date. Cases were matched 1:1 to controls by propensity
scores derived from logistic regression of pre-index patient
characteristics. Outcomes were all-cause and osteoporosis
(OP)-related HCRU in the 6-month post-index period.
Differences were assessed using McNemar's test. RESULTS: Of
the 62,863 eligible patients, 4,751 (7.6%) experienced an
upper GI event ≤ 4 months posttreatment initiation
(cases); 4,739 cases were matched with 4,739 controls.
Compared with controls, cases had higher rates of all-cause
HCRU (outpatient: 99.3% vs. 87.8%; inpatient: 20.2% vs.
6.4%; emergency room [ER]: 12.5% vs. 7.4%; all P less
than 0.0001) and OP-related HCRU (outpatient: 24.6% vs.
18.2%; inpatient: 3.4% vs. 1.0%; ER: 0.7% vs. 0.4%; all P
less than 0.05). CONCLUSIONS: Patients with upper GI
events had higher rates of all-cause and OP-related health
care utilization. Upper GI events may pose an incremental
HCRU burden among patients initiating BIS.},
Doi = {10.18553/jmcp.2015.21.9.811},
Key = {fds292779}
}
@article{fds272787,
Author = {Silverman, SL and Siris, E and Kendler, DL and Belazi, D and Brown, JP and Gold, DT and Lewiecki, EM and Papaioannou, A and Simonelli, C and Ferreira, I and Balasubramanian, A and Dakin, P and Ho, P and Siddhanti,
S and Stolshek, B and Recknor, C},
Title = {Persistence at 12 months with denosumab in postmenopausal
women with osteoporosis: interim results from a prospective
observational study.},
Journal = {Osteoporos Int},
Volume = {26},
Number = {1},
Pages = {361-372},
Year = {2015},
Month = {January},
ISSN = {0937-941X},
url = {http://dx.doi.org/10.1007/s00198-014-2871-6},
Abstract = {UNLABELLED: To determine persistence with subcutaneous
denosumab every 6 months in women being treated for
osteoporosis, we conducted a single-arm prospective,
observational study in the United States and Canada. Among
935 patients enrolled, 12-month persistence was 82%, with 66
patients (7%) reporting serious adverse events and 19
patients (2%) reporting fractures. INTRODUCTION: Increased
persistence with osteoporosis therapy is associated with
reduced fracture risk. Denosumab reduced fracture risk in
clinical trials; persistence in community settings is
undetermined. This study evaluates persistence with
denosumab in community practice in the United States (US)
and Canada. METHODS: In a 24-month multicenter, prospective,
single-arm, observational study, women being treated for
osteoporosis were enrolled ≤4 weeks after the first
subcutaneous injection of denosumab. For this 12-month
prespecified interim analysis, endpoints include persistence
(one injection at study entry and another within 6 months +
8 weeks), attributes associated with persistence (univariate
analysis), and serious adverse events (SAEs). RESULTS: Among
935 patients (mean age 71 years), mean baseline T-scores
were -2.18 (femoral neck) and -2.00 (lumbar spine); 50% of
patients had experienced osteoporotic fracture(s). At 12
months, 82 % of patients were persistent with denosumab.
Baseline factors significantly (p < 0.05) associated
with higher persistence included use of osteoporosis
medications >5 years previously, lumbar spine T-score >
-2.5, and treatment by female physicians (US). Lower
persistence was associated (p < 0.05) with psychiatric
diagnoses including depression, southern US residence, being
divorced, separated, or widowed (US), and prior hip fracture
(Canada). SAEs were reported in 66 patients (7%); no SAEs of
osteonecrosis of the jaw, atypical femoral fracture,
fracture healing complications, hypocalcemia, eczema, or
hypersensitivity were reported. Nineteen patients (2%)
reported osteoporotic fractures. CONCLUSIONS: The 12-month
persistence observed in this single-arm open-label study of
US and Canadian community practice extends the evidence
regarding denosumab's potential role in reducing fracture
risk in postmenopausal women with osteoporosis.},
Doi = {10.1007/s00198-014-2871-6},
Key = {fds272787}
}
@article{fds272786,
Author = {Shen, W and Burge, R and Naegeli, AN and Shih, J and Alam, J and Gold, DT and Silverman, S},
Title = {Psychometric properties of the osteoporosis assessment
questionnaire (OPAQ) 2.0: results from the multiple outcomes
of raloxifene evaluation (MORE) study.},
Journal = {Bmc Musculoskeletal Disorders},
Volume = {15},
Pages = {374},
Year = {2014},
Month = {November},
url = {http://dx.doi.org/10.1186/1471-2474-15-374},
Abstract = {BACKGROUND: We explored psychometric properties of the
Osteoporosis Assessment Questionnaire 2.0 in terms of
reliability, validity, and responsiveness with generic,
clinical, demographic, and preference-based data collected
from a population of postmenopausal women with osteoporosis.
METHODS: The Multiple Outcomes of Raloxifene Evaluation
study was a randomized, placebo-controlled, multinational
clinical trial evaluating efficacy and safety of raloxifene.
The Osteoporosis Assessment Questionnaire 2.0, a generic
quality of life measure (Nottingham Health Profile), and a
preference-based measure (Health Utilities Index) were
administered at baseline and annually. Psychometric
properties of the 14 Osteoporosis Assessment Questionnaire
2.0 domains were evaluated by standard statistical
techniques. RESULTS: This study included a subset of 1477
women from the Multiple Outcomes of Raloxifene Evaluation
study population completing the questionnaires. Mean
(standard deviation) age was 68.4 (6.8) years. Prevalent
vertebral fractures were found in 70% (n =1038) of women.
Internal consistency was >0.7 in 9 Osteoporosis Assessment
Questionnaire 2.0 domains. Correlations were moderate and
significant for similar Osteoporosis Assessment
Questionnaire 2.0 domain scores, Nottingham Health Profile
domains, and Health Utilities Index scores. All but 2
Osteoporosis Assessment Questionnaire 2.0 domains
distinguished between patients with or without prevalent
vertebral fractures and detected worsening with increased
number of vertebral fractures. Women with ≥ 1 incident
vertebral fracture generally had a greater worsening in
Osteoporosis Assessment Questionnaire 2.0 scores (excluding
social activity and support of family and friends) from
baseline to study endpoint compared with women without
incident vertebral fractures. CONCLUSIONS: Most domains in
the Osteoporosis Assessment Questionnaire 2.0 demonstrated
robust psychometric properties; however, several domains not
showing these criteria may need to be reassessed and removed
for a potentially shorter and validated version of the
Osteoporosis Assessment Questionnaire.},
Doi = {10.1186/1471-2474-15-374},
Key = {fds272786}
}
@article{fds292780,
Author = {Gold, DT and Silverman, SL and Chastek, BJ and Cheng, L-I and Hunter,
AG and White, JC and Van Voorhis and D and Stolshek,
BS},
Title = {A Patient Survey Study of Zoledronic Acid Utilization and
Factors Associated with Persistence.},
Journal = {Arthritis & Rheumatology},
Volume = {66},
Pages = {S509-S509},
Publisher = {WILEY-BLACKWELL},
Year = {2014},
Month = {October},
ISSN = {2326-5191},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344384902263&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds292780}
}
@article{fds272791,
Author = {Reynolds, K and Viswanathan, HN and Muntner, P and Harrison, TN and Cheetham, TC and Hsu, J-WY and Gold, DT and Silverman, S and Grauer, A and Morisky, DE and O'Malley, CD},
Title = {Validation of the Osteoporosis-Specific Morisky Medication
Adherence Scale in long-term users of bisphosphonates.},
Journal = {Qual Life Res},
Volume = {23},
Number = {7},
Pages = {2109-2120},
Year = {2014},
Month = {September},
ISSN = {0962-9343},
url = {http://dx.doi.org/10.1007/s11136-014-0662-3},
Abstract = {PURPOSE: To examine the psychometric properties and validity
of the 8-item Osteoporosis-Specific Morisky Medication
Adherence Scale (OS-MMAS-8) in postmenopausal women
prescribed bisphosphonates (BPs) for at least 15 months.
METHODS: A random sample of women aged ≥55 years with
osteoporosis prescribed daily or weekly BPs was identified.
Pharmacy fill data were extracted to calculate the
medication possession ratio (MPR). Eligible women were
stratified by low (<0.50), medium (0.50-0.79), or high
(≥0.80) MPR, with the a priori goal of recruiting 133
participants in each group. OS-MMAS-8 scores can range from
0 to 8 and were categorized as low (<6), medium (6 to <8),
and high (8) adherence. Internal consistency reliability
(Cronbach's alpha), test-retest reliability [intraclass
correlation coefficients (ICCs)] and convergent validity
(correlating OS-MMAS-8 with MPR and other self-reported
measures) were assessed. RESULTS: A total of 400 women out
of 449 respondents reported that they were still taking
their BPs at the time of the survey and completed OS-MMAS-8.
Overall, 38.5, 34.3, and 27.3% of participants had low,
medium, and high OS-MMAS-8 scores, respectively. The mean
(SD) MPRs according to OS-MMAS-8 scores (<6, 6 to <8 and 8)
were 56.9 (22.6), 69.0 (24.9), and 76.7 (26.4),
respectively. The correlation between OS-MMAS-8 and MPR was
0.36; p < 0.0001. Cronbach's alpha was 0.74, and the ICC was
0.83 (95% CI 0.76-0.88). CONCLUSIONS: OS-MMAS-8 has
acceptable psychometric properties for assessing medication
adherence in postmenopausal women prescribed therapy for
osteoporosis. Additional studies are needed to investigate
the psychometric properties of OS-MMAS-8 in other settings
and populations.},
Doi = {10.1007/s11136-014-0662-3},
Key = {fds272791}
}
@article{fds272789,
Author = {Nixon, A and Kerr, C and Doll, H and Naegeli, AN and Shingler, SL and Breheny, K and Burge, R and Gold, DT and Silverman,
S},
Title = {Osteoporosis Assessment Questionnaire-Physical Function
(OPAQ-PF): a psychometrically validated osteoporosis-targeted
patient reported outcome measure of daily activities of
physical function.},
Journal = {Osteoporos Int},
Volume = {25},
Number = {6},
Pages = {1775-1784},
Year = {2014},
Month = {June},
ISSN = {0937-941X},
url = {http://dx.doi.org/10.1007/s00198-014-2695-4},
Abstract = {UNLABELLED: The purpose of this study was to evaluate the
measurement properties of the Osteoporosis Assessment
Questionnaire-Physical Functioning (OPAQ-PF). Based on this
study, the OPAQ-PF has confirmed unidimensionality and
acceptable reliability, construct validity, and sensitivity
to change in a recent fracture/no recent fracture
osteoporosis sample. METHODS: Dimensionality was established
through exploratory and confirmatory factor analysis.
Patients completed three patient reported outcome (PRO)
measures and four performance-based measures (PBMs) at
baseline to enable an evaluation of construct validity.
Patients without a recent fracture completed the OPAQ-PF 2
weeks after baseline to enable an evaluation of test-retest
reliability. Ability to detect change and interpretation of
change were investigated following completion of the OPAQ-PF
12 and 24 weeks postbaseline by patients with a recent
fracture. RESULTS: A prospective psychometric validation
study in 144 postmenopausal women, with moderate to severe
osteoporosis, 37 of whom had experienced a recent fragility
fracture (<6 weeks). Unidimensionality was established for
the OPAQ-PF by factor analysis. The OPAQ-PF had good
internal consistency (α = 0.974) and test-retest
reliability (mean intraclass correlation coefficient (ICC)
0.993. The OPAQ-PF differentiated between patients
with/without recent fracture, and by severity of
osteoarthritis; it correlated strongly with
hypothesized-related scales and PBMs (r > 0.3, p < 0.001).
Ability to detect change was established with high
correlations between changes in OPAQ-PF score and changes in
global concept scores in recent fracture patients (r ≥
0.6, 24-week change). Effect size of change on OPAQ-PF score
increased by level of global change (p < 0.001).
Anchor-based methods identified an OPAQ-PF change of 10 at
an individual patient level and 20 at a group level as
meaningful to patients. CONCLUSIONS: The OPAQ-PF has
confirmed unidimensionality and acceptable reliability,
construct validity, and sensitivity to change in a recent
fracture/no recent fracture osteoporosis
sample.},
Doi = {10.1007/s00198-014-2695-4},
Key = {fds272789}
}
@article{fds272800,
Author = {Naegeli, AN and Nixon, A and Burge, R and Gold, DT and Silverman,
S},
Title = {Development of the Osteoporosis Assessment
Questionnaire--physical Function (OPAQ-PF): an
osteoporosis-targeted, patient-reported outcomes (PRO)
measure of physical function.},
Journal = {Osteoporos Int},
Volume = {25},
Number = {2},
Pages = {579-588},
Year = {2014},
Month = {February},
ISSN = {0937-941X},
url = {http://dx.doi.org/10.1007/s00198-013-2448-9},
Abstract = {UNLABELLED: We have developed a short, patient-reported
outcome questionnaire--the Osteoporosis Assessment
Questionnaire--Physical Function (OPAQ-PF)--that assesses
the impact of osteoporosis on physical function. OPAQ-PF
contains 15 items in three domains (mobility, physical
positions, and transfers) and has content validity in
osteoporosis patients with and without a history of
fracture. INTRODUCTION: This paper describes the development
of the Osteoporosis Assessment Questionnaire--Physical
Function (OPAQ-PF), a patient-reported outcome (PRO)
questionnaire based on OPAQ v.2.0 (60 items, 14 domains)
that assesses the impact of osteoporosis on physical
function. METHODS: OPAQ v.2.0 was administered to patients
with osteoporosis. Item response theory methodology and
clinical judgment were used to retain/eliminate items. The
resulting instrument was modified during two sets of concept
elicitation and cognitive debriefing interviews with
osteoporosis patients. RESULTS: Item response theory-based
analysis of OPAQ v.2.0 (n = 1,478) coupled with clinician
input resulted in the generation of a 21-item, six-domain
instrument with a frequency response format. Interview data
from 32 participants were used to modify this version and
led to generation of the final instrument, OPAQ-PF. This
final version has a severity response format and contains 15
items in three domains (mobility, physical positions, and
transfers) that group together to provide an overall
assessment of physical function in patients with
osteoporosis. Twenty-two of the 32 interview participants
(69 %) had previously sustained a fracture. Symptoms
occurred primarily in these patients. CONCLUSIONS: OPAQ-PF
represents a brief, focused, PRO instrument that assesses
physical function in patients with osteoporosis,
specifically related to mobility, physical positions, and
transfers. This questionnaire has content validity in
osteoporosis patients who have, and have not, sustained a
prior fracture.},
Doi = {10.1007/s00198-013-2448-9},
Key = {fds272800}
}
@article{fds272790,
Author = {Naegeli, AN and Nixon, A and Burge, R and Gold, DT and Silverman,
S},
Title = {Development of the osteoporosis assessment questionnaire -
Physical function (OPAQ-PF): An osteoporosis-targeted,
patient-reported outcomes (PRO) measure of physical
function},
Journal = {Osteoporosis International : a Journal Established as Result
of Cooperation Between the European Foundation for
Osteoporosis and the National Osteoporosis Foundation of the
Usa},
Volume = {25},
Number = {2},
Pages = {579-588},
Year = {2014},
Month = {January},
ISSN = {0937-941X},
url = {http://dx.doi.org/10.1007/s00198-013-2448-9},
Abstract = {Summary: We have developed a short, patient-reported outcome
questionnaire - the Osteoporosis Assessment Questionnaire -
Physical Function (OPAQ-PF)-that assesses the impact of
osteoporosis on physical function. OPAQ-PF contains 15 items
in three domains (mobility, physical positions, and
transfers) and has content validity in osteoporosis patients
with and without a history of fracture. Introduction: This
paper describes the development of the Osteoporosis
Assessment Questionnaire - Physical Function (OPAQ-PF), a
patient-reported outcome (PRO) questionnaire based on OPAQ
v.2.0 (60 items, 14 domains) that assesses the impact of
osteoporosis on physical function. Methods: OPAQ v.2.0 was
administered to patients with osteoporosis. Item response
theory methodology and clinical judgment were used to
retain/eliminate items. The resulting instrument was
modified during two sets of concept elicitation and
cognitive debriefing interviews with osteoporosis patients.
Results: Item response theory-based analysis of OPAQ v.2.0
(n =1,478) coupled with clinician input resulted in the
generation of a 21-item, six-domain instrument with a
frequency response format. Interview data from 32
participants were used to modify this version and led to
generation of the final instrument, OPAQ-PF. This final
version has a severity response format and contains 15 items
in three domains (mobility, physical positions, and
transfers) that group together to provide an overall
assessment of physical function in patients with
osteoporosis. Twenty-two of the 32 interview participants
(69%) had previously sustained a fracture. Symptoms occurred
primarily in these patients. Conclusions: OPAQ-PF represents
a brief, focused, PRO instrument that assesses physical
function in patients with osteoporosis, specifically related
to mobility, physical positions, and transfers. This
questionnaire has content validity in osteoporosis patients
who have, and have not, sustained a prior fracture. © The
Author(s) 2013.},
Doi = {10.1007/s00198-013-2448-9},
Key = {fds272790}
}
@article{fds344876,
Author = {George, LK and Gold, DT},
Title = {Life course perspectives on intergenerational and
generational connections},
Volume = {16},
Pages = {67-88},
Year = {2014},
Month = {January},
url = {http://dx.doi.org/10.4324/9781315059303},
Abstract = {Life course perspectives are recent additions to the
conceptual armamentarium of the social sciences.
Nonetheless, they already have demonstrated their value for
understanding temporal aspects of life patterns. At the
individual level, life course perspectives have proven to be
especially important in highlighting the ways that events
and decisions that occur earlier in life can have persistent
effects on the structure and quality of life at later points
in time. At the macro, population-based level, life course
perspectives have been useful in highlighting the ways in
whichsocial change generates different patterns of social
structure and personal biography across cohorts.},
Doi = {10.4324/9781315059303},
Key = {fds344876}
}
@article{fds272792,
Author = {Burge, R and Shen, W and Naegeli, AN and Alam, J and Silverman, S and Gold,
DT and Shih, T},
Title = {Use of health-related quality of life measures to predict
health utility in postmenopausal osteoporotic women: results
from the Multiple Outcomes of Raloxifene Evaluation
study.},
Journal = {Health and Quality of Life Outcomes},
Volume = {11},
Pages = {189},
Year = {2013},
Month = {November},
url = {http://dx.doi.org/10.1186/1477-7525-11-189},
Abstract = {BACKGROUND: The aim of this study is to examine the
associations between health utility (HU), health-related
quality of life (HRQoL), and patient characteristics in
postmenopausal osteoporotic (PMO) women. METHODS: Baseline
data from a subsample of 1,245 participants of the Multiple
Outcomes of Raloxifene Evaluation study, a randomized,
placebo-controlled, multinational clinical trial to evaluate
the safety and efficacy of raloxifene, were analyzed. The
study cohort included 694 participants from non-European
Union (non-EU) countries and 551 participants from EU
countries. All participants with complete baseline HU and
HRQoL assessments were included in the following analyses:
1) HU (HUI or EQ-5D) and HRQoL (QualEFFO or OPAQ and NHP)
associations; 2) HU variability explained by HRQoL domains;
and 3) the percentage of HU variability explained by
statistically significant (p < 0.05) HRQoL domains, after
adjusting for baseline characteristics. RESULTS: Several
domains were significantly associated with HU scores. HU
variance was well explained (41% to 61%) by 4 to 6 (p <
0.05) significant HRQoL domains. After controlling for
baseline characteristics, 48% to 64% of the HU variance was
well explained by 5 to 7 significant (p < 0.05) HRQoL
domains. Additional trend analyses detected statistically
significant decreases in HRQoL and HU scores with an
increased number of vertebral and non-vertebral fractures.
CONCLUSIONS: Both disease-targeted and generic HRQoL domains
were well correlated with HU. A large percentage (48% to
64%) of the HU variance was explained by HRQoL, after
adjusting for baseline characteristics. Both
disease-targeted and generic HRQoL measures were significant
predictors of HU. HRQoL and HU scores decreased with
increased vertebral and non-vertebral fractures.},
Doi = {10.1186/1477-7525-11-189},
Key = {fds272792}
}
@article{fds272802,
Author = {Reynolds, K and Muntner, P and Cheetham, TC and Harrison, TN and Morisky, DE and Silverman, S and Gold, DT and Vansomphone, SS and Wei,
R and O'Malley, CD},
Title = {Primary non-adherence to bisphosphonates in an integrated
healthcare setting.},
Journal = {Osteoporos Int},
Volume = {24},
Number = {9},
Pages = {2509-2517},
Year = {2013},
Month = {September},
ISSN = {0937-941X},
url = {http://dx.doi.org/10.1007/s00198-013-2326-5},
Abstract = {UNLABELLED: We estimated primary non-adherence to oral
bisphosphonate medication and examined the factors
associated with primary non-adherence. Nearly 30% of women
did not pick up their new bisphosphonate within 60 days.
Identifying barriers and developing interventions that
address patients' needs and concerns at the time a new
medication is prescribed are warranted. INTRODUCTION: To
estimate primary non-adherence to oral bisphosphonate
medications using electronic medical record data in a large,
integrated healthcare delivery system and to describe
patient and prescribing provider factors associated with
primary non-adherence. METHODS: Women aged 55 years and
older enrolled in Kaiser Permanente Southern California
(KPSC) with a new prescription for oral bisphosphonates
between December 1, 2009 and March 31, 2011 were identified.
Primary non-adherence was defined as failure to pick up the
new prescription within 60 days of the order date.
Multivariable logistic regression models were used to
investigate patient factors (demographics, healthcare
utilization, and health conditions) and prescribing provider
characteristics (demographics, years in practice, and
specialty) associated with primary non-adherence. RESULTS:
We identified 8,454 eligible women with a new bisphosphonate
order. Among these women, 2,497 (29.5%) did not pick up
their bisphosphonate prescription within 60 days of the
order date. In multivariable analyses, older age and
emergency department utilization were associated with
increased odds of primary non-adherence while prescription
medication use and hospitalizations were associated with
lower odds of primary non-adherence. Prescribing providers
practicing 10 or more years had lower odds of primary
non-adherent patients compared with providers practicing
less than 10 years. Internal medicine and rheumatology
providers had lower odds of primary non-adherent patients
than primary care providers. CONCLUSION: This study found
that nearly one in three women failed to pick up their new
bisphosphonate prescription within 60 days. Identifying
barriers and developing interventions aimed at reducing the
number of primary non-adherent patients to bisphosphonate
prescriptions are warranted.},
Doi = {10.1007/s00198-013-2326-5},
Key = {fds272802}
}
@article{fds272839,
Author = {Silverman, S and Calderon, A and Kaw, K and Childers, TB and Stafford,
BA and Brynildsen, W and Focil, A and Koenig, M and Gold,
DT},
Title = {Patient weighting of osteoporosis medication attributes
across racial and ethnic groups: a study of osteoporosis
medication preferences using conjoint analysis.},
Journal = {Osteoporos Int},
Volume = {24},
Number = {7},
Pages = {2067-2077},
Year = {2013},
Month = {July},
ISSN = {0937-941X},
url = {http://dx.doi.org/10.1007/s00198-012-2241-1},
Abstract = {UNLABELLED: We studied the ranking of osteoporosis (OP)
medication attributes in a convenience sample of four
different racial/ethnic groups in the United States. Our
study showed that postmenopausal women differ in the ranking
of OP medication attributes based on age, educational level,
income, and prior fracture history. INTRODUCTION: Decision
making about OP medication-related behavior relies heavily
on patient preferences about specific medication attributes.
Patients may decide to initiate, change, or stop therapies
based on ranking of perceived attributes of the therapy and
their personal attitudes toward those attributes. We used
MaxDiff, a form of conjoint analysis (Ryan and Farrar 2000),
to explore patient weighting of attributes across four
racial/ethnic groups at two sites in the United States and
defined four critical attributes that influence such
decisions (safety, efficacy, cost, and convenience) from
qualitative interviews. METHODS: We recruited a sample of
367 Postmenopausal (PM) women at risk of OP fractures from
four racial/ethnic groups: Caucasian (n = 100), African
American (n = 100), Asian American (n = 82), and
Hispanic American (n = 85). Respondents completed a
laptop-based questionnaire that included demographic items,
several short scales on medical care preference and OP
patient perceptions, and a MaxDiff procedure that determines
comparative ranking of attributes either as least important
or most important to their decisions. RESULTS: MaxDiff
analyses were done to evaluate the relative weight of
specific statements for each participant and to determine
whether racial/ethnic groups differed across dimensions.
Overall, participants in all four groups rated
efficacy > safety > cost > convenience.
CONCLUSIONS: Although there were no significant differences
among the racial/ethnic groups on overall ranking of
attributes, subgroup analyses revealed significant impact of
age, education, income, and prior fracture on these
decisions. The findings from this study suggest that
postmenopausal women differ in their ranking of OP
medication attributes, and healthcare providers must account
for personal preferences in their communication about and
selection of OP medications.},
Doi = {10.1007/s00198-012-2241-1},
Key = {fds272839}
}
@article{fds272788,
Author = {Gold, DT},
Title = {Condition Critical: Compliance and Persistence with
Osteoporosis Medications},
Pages = {1909-1921},
Publisher = {Elsevier},
Year = {2013},
Month = {January},
url = {http://dx.doi.org/10.1016/B978-0-12-415853-5.00082-0},
Abstract = {Since the introduction of alendronate as the first
bisphosphonate approved for osteoporosis prevention and
treatment, compliance and persistence with osteoporosis
medications has been a serious problem for healthcare
professionals and patients alike. Initially, it seemed as
though forgetfulness was most problematic in influencing
patients not to take medications as directed. However,
studies began to show that intentional nonadherence-that is,
choosing deliberately not to take a medication-is what is
driving poor medication-related behaviors. Extended dosing
intervals, different drug delivery methods, and other
changes seem not to have improved how patients take their
medicine, especially not for an asymptomatic disease. In
addition, primary nonadherence (never filling the
prescription) may account for over one-quarter of the
problems we face in trying to treat this devastating
disease. © 2013 Elsevier Inc. All rights
reserved.},
Doi = {10.1016/B978-0-12-415853-5.00082-0},
Key = {fds272788}
}
@article{fds272838,
Author = {Thomas, T and Horlait, S and Ringe, JD and Abelson, A and Gold, DT and Atlan, P and Lange, JL},
Title = {Oral bisphosphonates reduce the risk of clinical fractures
in glucocorticoid-induced osteoporosis in clinical
practice.},
Journal = {Osteoporos Int},
Volume = {24},
Number = {1},
Pages = {263-269},
Year = {2013},
Month = {January},
ISSN = {0937-941X},
url = {http://dx.doi.org/10.1007/s00198-012-2060-4},
Abstract = {UNLABELLED: This study aims to estimate bisphosphonate
effectiveness by comparing fracture incidence over time on
therapy in glucocorticoid-induced osteoporosis (GIO). From
this observational study, alendronate and risedronate
decreased clinical vertebral and nonvertebral fractures over
time. The effectiveness of each bisphosphonate is consistent
with their efficacies demonstrated on surrogate markers in
randomized controlled trials (RCTs). INTRODUCTION: This
study aims to estimate bisphosphonate effectiveness by
comparing fracture incidence over time on therapy with
fracture incidence during a short period after starting a
therapy. METHODS: The study population was a subgroup of a
larger cohort study comprising two cohorts of women aged
≥65 years, prescribed with alendronate or risedronate.
Within the two study cohorts, 11,007 women were identified
as having received glucocorticoids. Within each cohort, the
baseline incidence of clinical fractures at nonvertebral and
vertebral sites was defined by the initial 3-month period
after starting therapy. Relative to these baseline data, we
then compared the fracture incidence during the subsequent
12 months on therapy. RESULTS: The baseline incidence of
clinical nonvertebral and vertebral fractures was similar in
the alendronate cohort (5.22 and 5.79/100 person-years,
respectively) and in the risedronate cohort (5.51 and
5.68/100 person-years, respectively). Relative to the
baseline incidence, fracture incidence was significantly
lower in the subsequent 12 months in both cohorts of
alendronate (33 % lower at nonvertebral sites and 59 % at
vertebral sites) and risedronate (28 % lower at
nonvertebral sites and 54 % at vertebral sites).
CONCLUSION: From this observational study not designed to
compare drugs, both alendronate and risedronate decreased
clinical vertebral and nonvertebral fractures over time. The
reductions observed in fracture incidence, within each
cohort, suggest that the effectiveness of each
bisphosphonate in clinical practice is consistent with their
efficacies demonstrated on surrogate markers in randomized
controlled trials.},
Doi = {10.1007/s00198-012-2060-4},
Key = {fds272838}
}
@article{fds272841,
Author = {Reynolds, K and Viswanathan, HN and O'Malley, CD and Muntner, P and Harrison, TN and Cheetham, TC and Hsu, J-WY and Gold, DT and Silverman,
S and Grauer, A and Morisky, DE},
Title = {Psychometric properties of the Osteoporosis-specific Morisky
Medication Adherence Scale in postmenopausal women with
osteoporosis newly treated with bisphosphonates.},
Journal = {Ann Pharmacother},
Volume = {46},
Number = {5},
Pages = {659-670},
Year = {2012},
Month = {May},
ISSN = {1060-0280},
url = {http://dx.doi.org/10.1345/aph.1Q652},
Abstract = {BACKGROUND: Poor adherence to oral osteoporosis medications
is common. Strategies for improving adherence begin with
identification of the problem. The 8-item Morisky Medication
Adherence Scale for self-reported adherence to
antihypertensive medications was modified for assessing
adherence to oral osteoporosis medications. An evaluation of
the measurement properties of the Osteoporosis-Specific
Morisky Medication Adherence Scale (OS-MMAS) was needed.
OBJECTIVE: To examine the psychometric properties of the
OS-MMAS in women with postmenopausal osteoporosis. METHODS:
Five hundred women aged 55 years and older with osteoporosis
who were newly prescribed daily or weekly oral
bisphosphonates between May 15, 2010, and August 15, 2010,
were randomly selected from Kaiser Permanente Southern
California, a large integrated health care delivery system,
and mailed a self-administered survey that included the
8-item OS-MMAS, Self-Efficacy for Appropriate Medication Use
Scale (SEAMS), Beliefs about Medicines Questionnaire (BMQ),
Treatment Satisfaction Questionnaire for Medication (TSQM),
Gastrointestinal Symptom Rating Scale (GSRS), and 12-item
Short-Form Health Survey (SF-12v2). OS-MMAS scores can range
from 0 to 8, with higher scores indicating better medication
adherence. Internal consistency reliability was evaluated
using Cronbach α coefficient. Test-retest reliability was
assessed using intraclass correlation coefficients (ICCs) in
a subset of 102 participants. Construct validity was
assessed using confirmatory factor analysis and correlations
between OS-MMAS and related measures. RESULTS: Of 197
participants, 150 reported that they were still taking their
bisphosphonate at the time of the survey and completed the
OS-MMAS. Overall, 30.7%, 32.7%, and 36.7% had low, medium,
and high OS-MMAS scores (<6, 6 to <8, and 8, respectively).
Cronbach α was 0.82 and the ICC was 0.77. Convergent
validity was supported by significant correlations with
SEAMS, BMQ necessity, and TSQM scores. In confirmatory
factor analysis, a single-factor scale was supported.
CONCLUSIONS: The OS-MMAS showed strong psychometric
properties with good reliability and construct validity and
may provide a valuable assessment of self-reported
medication adherence in women newly prescribed oral
osteoporosis medications.},
Doi = {10.1345/aph.1Q652},
Key = {fds272841}
}
@article{fds316724,
Author = {Calderon, A and Silverman, SL and Gold, DT},
Title = {RELATIVE IMPORTANCE OF ATTRIBUTES THAT INFLUENCE
OSTEOPOROSIS DECISION-MAKING IN CAUCASIAN AND AFRICAN
AMERICAN POSTMENOPAUSAL WOMEN},
Journal = {Osteoporosis International : a Journal Established as Result
of Cooperation Between the European Foundation for
Osteoporosis and the National Osteoporosis Foundation of the
Usa},
Volume = {23},
Pages = {S458-S458},
Publisher = {SPRINGER LONDON LTD},
Year = {2012},
Month = {April},
ISSN = {0937-941X},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000309260300032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds316724}
}
@article{fds272840,
Author = {Solimeo, SL and Silverman, SL and Calderon, AD and Nguyen, A and Gold,
DT},
Title = {Measuring health-related quality of life (HRQOL) in
osteoporotic males using the Male OPAQ.},
Journal = {Osteoporos Int},
Volume = {23},
Number = {3},
Pages = {841-852},
Year = {2012},
Month = {March},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21528362},
Abstract = {UNLABELLED: The Male Osteoporosis Assessment Questionnaire
(OPAQ™) is a health-related quality of life (HRQOL)
instrument that can differentiate between men with and
without fracture. The Male OPAQ™ is a reliable and
validated instrument that may be utilized in clinical trials
seeking to include male populations. INTRODUCTION: Men with
osteoporosis (OP) experience poorer clinical outcomes than
do women with the disorder, but little is known about the
impact of OP on men's HRQOL. This study aimed to test the
validity, reliability, and ability to differentiate between
men with and without fracture of an HRQOL for men with
osteoporosis, the Male OPAQ™. METHODS: The OPAQ and
OPAQ-SV were tested for face validity in interviews with
male OP patients, and a revised, male-specific instrument
was developed. Thirty-seven men ages 50+ completed the Male
OPAQ™ and SF-12 at baseline and a two-week retest of the
Male OPAQ™. To analyze both the domain and dimension
scores, a normalization procedure was performed on the data
to determine health status scores from 0 to 100. Descriptive
statistics were calculated for each item and site.
Reliability and validity of the Male OPAQ™ were assessed
using Pearson's r. RESULTS: The Male OPAQ™ can
discriminate between men with and without fracture, and men
who have more fractures have poorer scores. Instrument
domains correspond to those of the SF-12. CONCLUSIONS: The
Male OPAQ(TM) is a brief and sensitive tool for measuring
HRQOL in men with OP. Further testing in a more diverse and
large sample is warranted.},
Doi = {10.1007/s00198-011-1625-y},
Key = {fds272840}
}
@article{fds272797,
Author = {Gold, DT},
Title = {Late-life death and dying in 21st-century
america},
Pages = {235-247},
Publisher = {Elsevier},
Year = {2011},
Month = {December},
url = {http://dx.doi.org/10.1016/B978-0-12-380880-6.00017-4},
Abstract = {The social and medical changes of the twentieth century have
been remarkable, and expectations for such change in the
twenty-first century seem almost without bounds. Medical
technology assists physicians to identify ways in which life
can be extended. This chapter examines how social factors
and institutions affect and contextualize death. All
societies must manage death, but cultural responses differ
substantially both across and within societies. Age, a
critical social factor, influences perceptions about death,
as do religiosity and education. Death is the end of life
and biological functioning. Several theories now offer
perspectives for understanding and studying death and dying.
Changing mortality rates and causes of death were driving
forces that increased the use of institutions as places of
death. Extensive empirical evidence suggests that care for
the terminally ill has high human and resource costs. The
heterogeneity of the American population-especially in late
life-results in wide variability of beliefs and attitudes
toward death and dying. Age, race/ethnicity, SES, and gender
all influence how people will cope with short-term and
long-term consequences of death and dying. © 2011 Elsevier
Inc. All rights reserved.},
Doi = {10.1016/B978-0-12-380880-6.00017-4},
Key = {fds272797}
}
@article{fds272837,
Author = {Gold, DT and Horne, R and Coon, CD and Price, MA and Borenstein, J and Varon, SF and Satram-Hoang, S and Macarios, D},
Title = {Development, reliability, and validity of a new Preference
and Satisfaction Questionnaire.},
Journal = {Value Health},
Volume = {14},
Number = {8},
Pages = {1109-1116},
Year = {2011},
Month = {December},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22152181},
Abstract = {OBJECTIVES: Existing questionnaires that assess preference
and/or satisfaction with postmenopausal bone loss treatments
were reviewed and determined to be inadequate for the
assessment of an oral pill versus a subcutaneous injection.
The Preference and Satisfaction Questionnaire (PSQ) was
developed to assess preference, satisfaction, and bother
with a weekly oral tablet versus a once every 6 months
subcutaneous injection for treatment of postmenopausal bone
loss. METHODS: Questions were developed based on literature
review and expert input. Content validity of the PSQ in this
patient population was assessed among current or previous
bisphosphonate users in group interviews, and item
comprehension and readability were also evaluated.
Reliability, validity, and structure of the questionnaire
were assessed in two phase 3 randomized clinical trials.
RESULTS: Twenty-four women participated in cognitive
interviews and found the PSQ understandable and acceptable.
Subsequently, 1583 trial participants took the PSQ.
Interitem correlations, ranging from 0.50 to 0.97 for
preference items, 0.85 to 0.94 for pill-satisfaction items,
and 0.84 to 0.92 for injection-satisfaction items, and a
well-fitting confirmatory factor analysis (root mean square
error of approximation 0.04, nonnormed fit index 0.99, and
root mean square residual 0.08) supported the structure of
the instrument. Cronbach's alpha reliability values for pill
satisfaction, injection satisfaction, pill bother, and
injection bother were 0.93, 0.89, 0.82, and 0.61,
respectively. Discriminative validity was indicated with
better satisfaction and bother scores being related to
adherence and the absence of adverse events. CONCLUSIONS:
The PSQ is a valid and reliable measure and may be a
valuable tool to assess patient preference and satisfaction
with a weekly oral tablet and 6-month subcutaneous injection
for postmenopausal bone loss.},
Doi = {10.1016/j.jval.2011.06.010},
Key = {fds272837}
}
@article{fds272836,
Author = {Solimeo, SL and Weber, TJ and Gold, DT},
Title = {Older men's explanatory model for osteoporosis.},
Journal = {The Gerontologist},
Volume = {51},
Number = {4},
Pages = {530-539},
Year = {2011},
Month = {August},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21310768},
Abstract = {PURPOSE: To explore the nature of men's experiences of
osteoporosis by developing an understanding of men's
explanatory models. DESIGN AND METHODS: This descriptive
study invited community-residing male osteoporosis patients
aged 50+ to participate in interviews about osteoporosis.
Participants were recruited from a hospital-affiliated bone
clinic. Men completed a questionnaire on demographic,
medication, and fracture-related information, and
descriptive statistics were calculated using Statistical
Package for the Social Sciences. Interviews elicited the 5
domains of men's explanatory model (Kleinman, 1987) and
open-ended information regarding men's experiences living
with this disorder. Narrative data were analyzed both for
content and inductively. RESULTS: Men's narratives
demonstrate that an osteoporosis diagnosis is accompanied by
negative psychosocial sequelae in this population. Men
defined it as a disease of the bone that may increase the
likelihood of fracture and that may cause pain. Participants
reported that osteoporosis is diagnosed by bone mineral
density (BMD) score and that disease progression is measured
by a decrease in BMD and an increase in pain or new
fractures. Men described a reluctance to take medications,
dissatisfaction with side effects, and a perception that
osteoporosis treatment in men had little basis in long-term
medication efficacy or safety data. They viewed osteoporosis
as a degenerative chronic disease with an overall stable
course. IMPLICATIONS: Participants' explanatory models for
osteoporosis are substantively different than clinical
models. These differences provide a foundation for exploring
the importance of gender to osteoporosis outcomes, a context
for making sense of men's bone health behavior, and a clear
case for an increase in advocacy and educational efforts for
men who have or are at risk for osteoporosis.},
Doi = {10.1093/geront/gnq123},
Key = {fds272836}
}
@article{fds272835,
Author = {Smith, GM and Lewis, VR and Whitworth, E and Gold, DT and Thornburg,
CD},
Title = {Growing up with sickle cell disease: a pilot study of a
transition program for adolescents with sickle cell
disease.},
Journal = {Journal of Pediatric Hematology/Oncology},
Volume = {33},
Number = {5},
Pages = {379-382},
Year = {2011},
Month = {July},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21602723},
Abstract = {We implemented the Duke Sickle Cell Disease (SCD) Transition
Program for adolescents with SCD and investigated the
knowledge about SCD; concerns and emotions about
transitioning; and the initial impact of the Transition
Program. Thirty-three adolescents participated in the
initial study. Gaps in knowledge included ethnicities
affected by SCD and inheritance of SCD. Adolescents were
primarily concerned about transferring to a new medical
team. There was a mix of both positive and negative emotions
that varied over time. Overall, we have identified
educational gaps and concerns and emotions about
transitioning, which we will address through the Duke SCD
Transition Program.},
Doi = {10.1097/MPH.0b013e318211bb2e},
Key = {fds272835}
}
@article{fds316726,
Author = {Silverman, SL and Gold, DT},
Title = {SELF EFFICACY ACROSS BONE HEALTH BEHAVIORS IS NOT
CONSISTENT},
Journal = {Osteoporosis International : a Journal Established as Result
of Cooperation Between the European Foundation for
Osteoporosis and the National Osteoporosis Foundation of the
Usa},
Volume = {22},
Pages = {S437-S437},
Publisher = {SPRINGER LONDON LTD},
Year = {2011},
Month = {May},
ISSN = {0937-941X},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000309257500026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds316726}
}
@article{fds272833,
Author = {Gold, DT},
Title = {Understanding patient compliance and persistence with
osteoporosis therapy.},
Journal = {Drugs Aging},
Volume = {28},
Number = {4},
Pages = {249-255},
Year = {2011},
Month = {April},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21553400},
Abstract = {Chronic non-terminal diseases, including postmenopausal
osteoporosis, are associated with poor treatment compliance
and persistence. The longer a patient with osteoporosis
complies and persists with treatment, the lower the risk of
fracture. Retrospective studies with emphasis on real-world
data have led to a greater understanding of the factors
affecting medication compliance and persistence, and their
association with improved treatment outcomes. However, these
data do not contain information about patient choices of
medication or patient commitment to particular medication
regimens. Patient preferences can affect compliance and
persistence behaviours. While recent evidence questions the
importance of dosing regimen in patient preferences, other
recent data show that medication efficacy and safety remain
the most important determinants of patient preference.
Informed patient decision making about treatment options,
adverse effects and outcomes can have a beneficial impact on
medication-taking behaviour. Healthcare professionals play a
crucial role in the management of factors associated with
poor compliance and persistence with osteoporosis therapies.
Education about disease consequences and differences among
treatment options, as well as treatment monitoring and
positive reinforcement, are crucial to improving medication
compliance and persistence in osteoporotic
patients.},
Doi = {10.2165/11586880-000000000-00000},
Key = {fds272833}
}
@article{fds272834,
Author = {Silverman, SL and Gold, DT},
Title = {Healthy users, healthy adherers, and healthy
behaviors?},
Journal = {J Bone Miner Res},
Volume = {26},
Number = {4},
Pages = {681-682},
Year = {2011},
Month = {April},
ISSN = {0884-0431},
url = {http://dx.doi.org/10.1002/jbmr.384},
Doi = {10.1002/jbmr.384},
Key = {fds272834}
}
@article{fds272831,
Author = {Silverman, SL and Schousboe, JT and Gold, DT},
Title = {Oral bisphosphonate compliance and persistence: a matter of
choice?},
Journal = {Osteoporos Int},
Volume = {22},
Number = {1},
Pages = {21-26},
Year = {2011},
Month = {January},
ISSN = {0937-941X},
url = {http://dx.doi.org/10.1007/s00198-010-1274-6},
Abstract = {Compliance to oral bisphosphonates is suboptimal, with
negative consequences of increased healthcare utilization
and less effective fracture risk reduction. Extending dose
interval increased adherence only moderately. We used
literature derived from multiple chronic conditions to
examine the problem of noncompliance with osteoporosis
medication. We reviewed the literature on adherence to
osteoporosis medication as well as that across multiple
chronic conditions to understand what is known about the
cause of the poor adherence. Poor compliance to oral
medications is due mostly, not to forgetfulness, but to
deliberate choice. Gender differences and style of
healthcare management also play a role. Preliminary data
suggest psychobehavioral interventions may help to improve
motivation. We need to understand better reasons for poor
compliance before effective interventions can be developed.
Forgetfulness is only a small part of poor compliance.
Patient preferences must be considered in medication
decision making.},
Doi = {10.1007/s00198-010-1274-6},
Key = {fds272831}
}
@article{fds326235,
Author = {Gold, DT and Weinstein, DL and Pohl, G and Krohn, KD and Chen, Y and Meadows, ES},
Title = {Factors Associated with Persistence with Teriparatide
Therapy: Results from the DANCE Observational
Study.},
Journal = {J Osteoporos},
Volume = {2011},
Pages = {314970},
Year = {2011},
url = {http://dx.doi.org/10.4061/2011/314970},
Abstract = {Purpose. Determine patient-reported reasons for
discontinuation with teriparatide. Methods. Patients taking
teriparatide in a multicenter, prospective, and
observational study were given three questionnaires:
baseline, follow-up questionnaire 1 (QF1, 2 to 6 months),
and follow-up questionnaire 2 (QF2, 12 months).
Discontinuation reported at QF1 and QF2 was defined as
"early" and "late," respectively, and remaining patients
were considered persistent. Cochran-Armitage trend test was
used to identify factors associated with discontinuation.
Results. Side effects, concern about improper use, injection
difficulties, and several patient-perceived physician issues
were associated with early discontinuation. Low
patient-perceived importance of continuing treatment, side
effects, difficulty paying, and low patient-perceived
physician knowledge were associated with late
discontinuation. The most common specific reasons selected
for discontinuing treatment were "concerns about treatment
outweighing the benefits" (n = 53) and "difficulty paying"
(n = 47). Conclusions. Persistence with teriparatide is
dependent on managing side effects, addressing financial
challenges, proper training, and obtaining support from the
healthcare provider.},
Doi = {10.4061/2011/314970},
Key = {fds326235}
}
@article{fds272798,
Author = {Gold, DT and Silverman, SL},
Title = {Adverse Health Outcomes in Men with Osteoporosis},
Pages = {395-401},
Publisher = {Elsevier},
Year = {2010},
Month = {December},
url = {http://dx.doi.org/10.1016/B978-0-12-374602-3.00032-8},
Abstract = {The evidence about men and osteoporosis has changed over the
last 30 years. Recent data suggest that at least 20% of
people with osteoporosis are men. That means that 2 million
men or more already have osteoporosis and another 12 million
are at risk of the disease. As life expectancy in the USA
continues to rise, osteoporosis prevalence in men will
increase. In light of these changing demographics, a better
understanding of the incidence and gender-specific
consequences of osteoporosis in men is needed. This chapter
reviews research findings from the last decade that
specifically illuminate the adverse outcomes of osteoporosis
and consequent fractures in men. These outcomes include, but
are not limited to, physical morbidity, psychosocial
outcomes (including health-related quality of life) and
mortality. Although the empirical evidence about men and
their osteoporosis outcomes is somewhat limited, some recent
studies have begun to help researchers understand what
happens when men with osteoporosis experience fractures. ©
2010 Elsevier Inc. All rights reserved.},
Doi = {10.1016/B978-0-12-374602-3.00032-8},
Key = {fds272798}
}
@article{fds272832,
Author = {Silverman, S and Gold, DT},
Title = {Compliance and persistence with osteoporosis medications: a
critical review of the literature.},
Journal = {Rev Endocr Metab Disord},
Volume = {11},
Number = {4},
Pages = {275-280},
Year = {2010},
Month = {December},
ISSN = {1389-9155},
url = {http://dx.doi.org/10.1007/s11154-010-9138-0},
Abstract = {It is widely acknowledged that compliance and persistence
with oral osteoporosis medications, particularly with
bisphosphonates, is poor. Several excellent reviews have
been written on compliance and persistence with osteoporosis
medications and have discussed improvements seen with
extended dosing intervals. This review begins with studies
on extended dosing intervals to examine the limitations of
administrative claims data. It also looks at compliance and
persistence across multiple medical conditions, examining
the importance of prescription fulfillment, intentional
choice, causation and possible interventions.},
Doi = {10.1007/s11154-010-9138-0},
Key = {fds272832}
}
@article{fds272829,
Author = {Abelson, A and Ringe, JD and Gold, DT and Lange, JL and Thomas,
T},
Title = {Longitudinal change in clinical fracture incidence after
initiation of bisphosphonates.},
Journal = {Osteoporos Int},
Volume = {21},
Number = {6},
Pages = {1021-1029},
Year = {2010},
Month = {June},
ISSN = {0937-941X},
url = {http://dx.doi.org/10.1007/s00198-009-1046-3},
Abstract = {SUMMARY: There are differences in the risk profile of
patients prescribed alendronate, risedronate, or
ibandronate. Observed reductions in fracture incidence over
time suggest that the effectiveness of each bisphosphonate
in clinical practice has been consistent with their
efficacies demonstrated in randomized controlled trials.
INTRODUCTION: Observational studies of bisphosphonate
effectiveness for fracture prevention are subject to bias
from unknown characteristics of baseline fracture risk at
the start of therapy. The fracture incidence during the
short period after starting a bisphosphonate and before any
expected clinical benefit likely reflects baseline fracture
risk. Bisphosphonate effectiveness may then be estimated by
measuring the change in fracture incidence over time on
therapy. METHODS: Administrative billing data were used to
follow three cohorts of women aged 65 and older (total n =
210,144) after starting therapy either on alendronate,
risedronate, or ibandronate in the USA between market
introduction and 2006. Within each cohort, the baseline
incidence of clinical fractures at the hip, vertebral, and
nonvertebral sites was defined by the initial 3-month period
after starting therapy. Relative to these baselines, we then
compared the fracture incidence during the subsequent 12
months on therapy. RESULTS: At the start of therapy, the
ibandronate cohort was younger and had fewer prior fractures
than either the risedronate or alendronate cohorts.
Accordingly, the baseline incidence of hip fractures was
higher in the risedronate cohort (0.90 per 100 person-years)
and in the alendronate cohort (0.77) than in the ibandronate
cohort (0.64). Relative to the baseline incidence, fracture
incidence was significantly lower in the subsequent 12
months in both cohorts of alendronate (18% lower at hip, 28%
at nonvertebral sites, and 57% at vertebral sites) and
risedronate (27% lower at hip, 21% at nonvertebral sites,
and 54% at vertebral sites). In the ibandronate cohort, the
fracture incidence was lower (31%) only at vertebral sites.
CONCLUSIONS: Differences in the baseline fracture incidence
among the cohorts may reflect differences in the risk
profile of patients prescribed each bisphosphonate. The
reductions observed in fracture incidence over time within
each cohort suggest that the effectiveness of each
bisphosphonate in clinical practice has been consistent with
their efficacies demonstrated in randomized controlled
trials.},
Doi = {10.1007/s00198-009-1046-3},
Key = {fds272829}
}
@article{fds272830,
Author = {Kendler, DL and Bessette, L and Hill, CD and Gold, DT and Horne, R and Varon, SF and Borenstein, J and Wang, H and Man, H-S and Wagman, RB and Siddhanti, S and Macarios, D and Bone, HG},
Title = {Preference and satisfaction with a 6-month subcutaneous
injection versus a weekly tablet for treatment of low bone
mass.},
Journal = {Osteoporos Int},
Volume = {21},
Number = {5},
Pages = {837-846},
Year = {2010},
Month = {May},
ISSN = {0937-941X},
url = {http://dx.doi.org/10.1007/s00198-009-1023-x},
Abstract = {UNLABELLED: The Preference and Satisfaction Questionnaire
(PSQ) compares patient preference and satisfaction between a
6-month subcutaneous injection and weekly oral tablet for
treatment of bone loss. Patients preferred and were more
satisfied with a treatment that was administered less
frequently, suggesting the acceptability of the 6-month
injection for treatment of bone loss. INTRODUCTION: The PSQ
compares patient preference and satisfaction between a
6-month subcutaneous injection and a weekly oral tablet for
treatment of bone loss. METHODS: Postmenopausal women with
low bone mass who enrolled in two separate randomized phase
3 double-blind, double-dummy studies received a 6-month
subcutaneous denosumab injection (60 mg) plus a weekly oral
placebo or a weekly alendronate tablet (70 mg) plus a
6-month subcutaneous placebo injection. After 12 months,
patients completed the PSQ to rate their preference,
satisfaction, and degree of bother with each regimen.
RESULTS: Most enrolled patients (1,583 out of 1,693; 93.5%)
answered >or=1 item of the PSQ. Significantly more patients
preferred and were more satisfied with the 6-month injection
versus the weekly tablet (P < 0.001). More patients reported
no bother with the 6-month injection (90%) than the weekly
tablet (62%). CONCLUSION: Patients preferred, were more
satisfied, and less bothered with a 6-month injection
regimen for osteoporosis.},
Doi = {10.1007/s00198-009-1023-x},
Key = {fds272830}
}
@article{fds272793,
Author = {Gold, DT},
Title = {Compliance and Persistence With Osteoporosis
Medications},
Pages = {254-256},
Publisher = {JOHN WILEY & SONS INC},
Year = {2009},
Month = {December},
url = {http://dx.doi.org/10.1002/9780470623992.ch54},
Doi = {10.1002/9780470623992.ch54},
Key = {fds272793}
}
@article{fds272828,
Author = {Gold, DT and Trinh, H and Safi, W},
Title = {Weekly versus monthly drug regimens: 1-year compliance and
persistence with bisphosphonate therapy.},
Journal = {Curr Med Res Opin},
Volume = {25},
Number = {8},
Pages = {1831-1839},
Year = {2009},
Month = {August},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19530982},
Abstract = {OBJECTIVE: To determine compliance and persistence with
weekly risedronate and monthly ibandronate therapy. RESEARCH
DESIGN AND METHODS: The IMS longitudinal prescription
database was used to evaluate compliance (mean medication
possession ratio), persistence (days until a gap >90 days
between prescriptions occurred) and cumulative drug
availability (ratio of drug supply and days between first
fill date and the end of the study) among patients taking
weekly risedronate or monthly ibandronate over a 12-month
period using three retrospective cohorts: overall sample,
new to osteoporosis therapy, and new to osteoporosis therapy
after initial market availability. Comparisons were made
between drug groups for each measure. RESULTS: Compliance
was significantly different for the overall sample (80.15
+/- 18.90% for risedronate vs. 74.68 +/- 22.56% for
ibandronate; p < 0.0001), and marginally different during
the initial post-marketing year (p = 0.091), but not for
patients new to therapy (p = 0.693). Persistence was
significantly different for the overall sample (250.04 +/-
132.34 days for risedronate vs. 151.54 +/- 137.24 days for
ibandronate; p < 0.0001), for patients new to therapy
(154.38 +/- 135.29 days for risedronate vs. 133.33 +/-
130.36 days for ibandronate; p < 0.0001), and after initial
market availability (165.00 +/- 141.58 days for risedronate
vs. 133.33 +/- 130.36 days for ibandronate; p < 0.0001).
Mean cumulative drug availability was significantly
different for the overall sample (64.54 +/- 29.86% for
risedronate vs. 43.38 +/- 32.96% for ibandronate; p <
0.0001), for patients new to therapy (40.34 +/- 31.84% for
risedronate vs. 36.05 +/- 31.09% for ibandronate; p <
0.0001), and after initial market availability (43.17 +/-
33.34% for risedronate vs. 36.05 +/- 31.09% for ibandronate;
p < 0.0001). CONCLUSIONS: Patient compliance, persistence
and cumulative drug availability were similar for monthly
ibandronate and weekly risedronate dosing. Interpretations
from this study are limited by assumptions of persistence
based on initial drug dosing and selected refill gap length
measured. Furthermore, comparisons with earlier studies are
difficult, due to differences in definitions of compliance
and persistence. Further studies are needed to explore
factors affecting patterns of medication use, particularly
the effects of patient preference, acceptance, and patient
education on compliance and persistence.},
Doi = {10.1185/03007990903035604},
Key = {fds272828}
}
@article{fds272842,
Author = {Whitson, HE and Sanders, LL and Pieper, CF and Morey, MC and Oddone, EZ and Gold, DT and Cohen, HJ},
Title = {Correlation between symptoms and function in older adults
with comorbidity.},
Journal = {Journal of the American Geriatrics Society},
Volume = {57},
Number = {4},
Pages = {676-682},
Year = {2009},
Month = {April},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19392960},
Abstract = {OBJECTIVES: To describe the relationship between symptom
scores and mobility function measures, assess whether
symptom scores and disease scores are similarly associated
with mobility function, and identify clusters of symptoms
that are most strongly associated with functional status in
older adults. DESIGN: Secondary analysis of cross-sectional
data from three cohorts. SETTING: Academic medical center.
PARTICIPANTS: One hundred ninety-five community-dwelling
subjects with poor flexibility or cardiorespiratory fitness
(fitness cohort), 211 female retirement community residents
with vertebral fractures (VF cohort), and 61 subjects with
Parkinson's disease (PD cohort). MEASUREMENTS: Twenty-item
self-reported symptom scale, 17-item self-reported disease
scale, Medical Outcomes Study 36-item Short Form Survey
(SF-36) Physical Functioning Scale, 5-item Nagi Disability
scale, 10-m walk time, supine to stand time. RESULTS:
Symptom scores correlated with mobility function measures
(Spearman correlation coefficients ranged from 0.222 to
0.509) at least as strongly as, if not more strongly than,
did disease scores. Symptom scores remained associated with
functional outcomes after controlling for disease score and
demographic variables. Adding symptom scores to models that
contained disease scores significantly increased the
association with functional outcomes. In the fitness cohort,
muscle weakness was the most explanatory single symptom,
associated with an average decrease of 17.8 points on the
Physical Functioning Scale. A model that included only
muscle weakness, pain, and shortness of breath accounted for
21.2% of the variability in the Physical Functioning Score.
CONCLUSION: Symptoms represent useful indicators of
disability burden in older adults and are promising targets
for interventions to improve function in medically complex
patients.},
Doi = {10.1111/j.1532-5415.2009.02178.x},
Key = {fds272842}
}
@article{fds272796,
Author = {Gold, DT and Solimeo, S},
Title = {The Conundrum of Compliance and Persistence with Oral
Bisphosphonates for Postmenopausal Osteoporosis},
Pages = {1547-1553},
Publisher = {Elsevier},
Year = {2008},
Month = {December},
url = {http://dx.doi.org/10.1016/B978-012370544-0.50066-5},
Doi = {10.1016/B978-012370544-0.50066-5},
Key = {fds272796}
}
@article{fds272826,
Author = {Gold, DT and Bonnick, SL and Amonkar, MM and Kamel, HK and Agarwal, S and Zaidi, M},
Title = {Descriptive analysis of concomitant prescription medication
patterns from 1999 to 2004 among US women receiving daily or
weekly oral bisphosphonate therapy.},
Journal = {Gender Medicine},
Volume = {5},
Number = {4},
Pages = {374-384},
Year = {2008},
Month = {December},
ISSN = {1550-8579},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19108810},
Abstract = {BACKGROUND: To improve medication-taking behavior, it is
important to identify factors that may contribute to
suboptimal compliance and persistence with osteoporosis
medications. OBJECTIVE: The purpose of this descriptive
analysis was to identify concurrent prescription medication
use (number and type) among women receiving daily or weekly
oral bisphosphonate therapy. METHODS: Patient prescription
data were collected from November 1999 to June 2004 from a
US patient claims database accessed through Wolters Kluwer
Health (formerly NDC Health), which represents >65 million
patients annually. Women aged >or=50 years who were
receiving daily or weekly oral bisphosphonate medication
during the study months were included. Concomitant
medications were defined based on >or=14 days of
prescription supply in the same month as bisphosphonate
therapy. Data were examined to determine the frequency with
which certain drugs and drug classes were prescribed
concomitantly with bisphosphonates. Each study month was
treated independently to assess concomitant medication use.
RESULTS: Over the study period, the number of female
bisphosphonate recipients in the database increased from
78,909 to 250,286. At the end of the study, 16.2%, 12.2%,
8.7%, and 19.1% of bisphosphonate recipients were prescribed
3, 4, 5, or >or=6 concomitant medications, respectively. The
most commonly prescribed concomitant drug classes were
cholesterol reducers, diuretics, beta-blockers, calcium
channel blockers, synthetic thyroid hormones,
angiotensin-converting enzyme inhibitors, systemic
analgesics/anti-inflammatory drugs, and antispasmodics/antisecretory
drugs. From July 2001 until the end of the study, the number
of concomitant medications was higher for women receiving
daily bisphosphonates than for those receiving weekly
bisphosphonates, 4.16 versus 3.77 as of June 2004. In
addition, the mean number of concomitant medications
prescribed increased with age: in the aged 50 to 64 years
cohort, the aged 65 to 74 years cohort, and the aged >or=75
years cohort, the mean number was 3.09, 3.62, and 3.97,
respectively, as of June 2004. CONCLUSION: This analysis
suggests that women prescribed bisphosphonates have a high
medication burden, with the majority of patients (56%)
taking >or=3 concomitant prescription medications.},
Doi = {10.1016/j.genm.2008.10.004},
Key = {fds272826}
}
@article{fds272827,
Author = {Whitson, HE and Sanders, L and Pieper, CF and Gold, DT and Papaioannou,
A and Richards, JB and Adachi, JD and Lyles, KW and CaMos Research
Group},
Title = {Depressive symptomatology and fracture risk in
community-dwelling older men and women.},
Journal = {Aging Clinical and Experimental Research},
Volume = {20},
Number = {6},
Pages = {585-592},
Year = {2008},
Month = {December},
ISSN = {1594-0667},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19179844},
Abstract = {BACKGROUND AND AIMS: Previous studies suggest that
depression increases risk of falls, low bone mineral
density, and fractures. Our aim was to evaluate whether
depressive symptomatology alone predicts 5- year clinical
fracture risk in older adults. METHODS: In this secondary
analysis of a community-based, prospective cohort study
including 4175 women and 1652 men in Canada, depressive
symptomatology was assessed at baseline by the mental health
inventory-5 (MHI-5) and the mental component score (MCS) of
the short form 36 questionnaire (SF-36). Fracture events
were assessed annually for five years; all reported incident
fragility fractures were confirmed radiographically.
RESULTS: Depressive symptomatology did not predict time to
first fracture in men (hazard ratio [HR] 0.86, 95%
confidence interval [CI] 0.45-1.65) or women (HR 1.09, 95%
CI 0.86-1.39). Results were similar after controlling for
potential confounders. Depressive symptoms were not
significantly associated with baseline bone mineral density
at the lumbar spine or femoral neck. Women with depressive
symptoms were more likely to report falls in the previous
month (odds ratio [OR] 1.52, 95% CI 1.12-2.06, p=0.01). This
association did not achieve statistical significance in men
(OR 1.71, 95% CI 0.96-3.04, p=0.07). CONCLUSION: In this
large, community cohort, depressive symptomatology did not
predict five-year risk of clinical fracture. Further
research is needed to determine if individuals with major
depressive disorder (MDD) are at higher fracture risk and
whether neuroendocrine or hormonal dysregulation might
contribute to such risk in MDD.},
Doi = {10.1007/BF03324888},
Key = {fds272827}
}
@article{fds272825,
Author = {Kleerekoper, M and Gold, DT},
Title = {Osteoporosis prevention and management: an evidence-based
review.},
Journal = {Clin Obstet Gynecol},
Volume = {51},
Number = {3},
Pages = {556-563},
Year = {2008},
Month = {September},
ISSN = {0009-9201},
url = {http://dx.doi.org/10.1097/GRF.0b013e3181809ae0},
Abstract = {Evidence-based guidelines that have been prepared by many
professional organizations aimed at assisting the clinician
in the initial evaluation of postmenopausal women who should
be considered for bone mineral density evaluation by
dual-energy x-ray absorptiometry; history, physical
examination, and laboratory testing in those women being
considered for pharmacologic intervention; and monitoring
and management of women for whom therapy is prescribed are
discussed.},
Doi = {10.1097/GRF.0b013e3181809ae0},
Key = {fds272825}
}
@article{fds272824,
Author = {Silverman, SL and Gold, DT},
Title = {Compliance and persistence with osteoporosis
therapies.},
Journal = {Current Rheumatology Reports},
Volume = {10},
Number = {2},
Pages = {118-122},
Year = {2008},
Month = {April},
ISSN = {1523-3774},
url = {http://dx.doi.org/10.1007/s11926-008-0021-x},
Abstract = {The US Food and Drug Administration has approved a diverse
group of effective osteoporosis therapies. However, these
therapies obviously only work when patients with
osteoporosis take them. Data from retrospective
observational databases have shown poor compliance and
persistence with all osteoporosis drugs, particularly oral
bisphosphonate therapy. Patients on weekly therapies are
more compliant and persistent than those on daily dosing.
Data have also shown decreased fracture risk, decreased
health care utilization, and lower costs in compliant and
persistent patients.},
Doi = {10.1007/s11926-008-0021-x},
Key = {fds272824}
}
@article{fds272795,
Author = {Brunton, S and Carmichael, B and Gold, D and Hull, B and Kauffman, TL and Papaioannou, A and Rasch, R and Stracke, HHG and Truumees,
E},
Title = {Osteoporosis},
Pages = {121-128},
Publisher = {Elsevier},
Year = {2007},
Month = {December},
url = {http://dx.doi.org/10.1016/B978-0-443-10233-2.50026-2},
Doi = {10.1016/B978-0-443-10233-2.50026-2},
Key = {fds272795}
}
@article{fds272823,
Author = {Silverman, SL and Gold, DT and Cramer, JA},
Title = {Reduced fracture rates observed only in patients with proper
persistence and compliance with bisphosphonate
therapies.},
Journal = {South Med J},
Volume = {100},
Number = {12},
Pages = {1214-1218},
Year = {2007},
Month = {December},
ISSN = {0038-4348},
url = {http://dx.doi.org/10.1097/SMJ.0b013e31815a9685},
Abstract = {Numerous studies have analyzed data from administrative
claims databases to determine persistence and compliance
with bisphosphonate therapy for osteoporosis; several of
these studies have also examined how persistence and
compliance with therapy affect fracture outcomes. All of the
studies included in this review demonstrated that patients
who were persistent or compliant with therapy had a
decreased risk of fracture. None, however, adequately
addressed the question of what level of persistence or
compliance is necessary to obtain a reduced risk of
fracture. There is agreement among studies that compliance
and persistence rates are suboptimal for all osteoporosis
treatments. Measures to improve persistence and compliance
with osteoporosis medications are needed if patients are to
achieve the full clinical benefit of treatment.},
Doi = {10.1097/SMJ.0b013e31815a9685},
Key = {fds272823}
}
@article{fds272821,
Author = {Gold, DT and Silverman, SL},
Title = {Compliance and persistence with osteoporosis therapies: We
can do better},
Journal = {Future Rheumatology},
Volume = {2},
Number = {5},
Pages = {443-445},
Publisher = {Future Medicine Ltd},
Year = {2007},
Month = {October},
ISSN = {1746-0816},
url = {http://dx.doi.org/10.2217/17460816.2.5.443},
Doi = {10.2217/17460816.2.5.443},
Key = {fds272821}
}
@article{fds272822,
Author = {Cramer, JA and Silverman, SL and Gold, DT},
Title = {Methodological considerations in using claims databases to
evaluate persistence with bisphosphonates for
osteoporosis.},
Journal = {Curr Med Res Opin},
Volume = {23},
Number = {10},
Pages = {2369-2377},
Year = {2007},
Month = {October},
ISSN = {0300-7995},
url = {http://dx.doi.org/10.1185/030079907X226311},
Abstract = {OBJECTIVE: To demonstrate that retrospective analyses of
medication persistence require careful methodological
approaches to assure accuracy and consistency across various
types of databases. Bisphosphonates (BPs) are used as an
example because of the availability of diverse dosing
options that can create a unique set of challenges for
persistence analyses. METHODS: Reports of BP persistence
were compared for methodological approaches, including data
source, duration of follow-up, allowed gap for persistence,
and presentation of results. MAIN OUTCOME MEASURES:
Medication persistence. RESULTS: Comparisons among reports
of BP persistence for weekly and monthly formulations
revealed inconsistent definitions and a variety of methods.
Persistence analyses varied greatly, particularly in allowed
gaps and adjustment for demographic and clinical
characteristics that affected results. Persistence with
weekly dosing was 179-249 days, with 24-78% remaining on
treatment at 1 year. Analyses of persistence with monthly
treatment was complicated by the variety of gap lengths
(30-90 days). The studies reviewed had many limitations,
including lack of an established threshold for efficacy,
inadequacy of information in databases, and potential biases
in case selection (treatment-naive or experienced).
CONCLUSIONS: The limitations of published studies reveal the
need for a more consistent approach to medication
persistence analyses using claims databases to allow for
comparison across reports. The analysis plan should present
definitions of all terms, details of all methods and types
of adjustments needed for demographic and clinical
characteristics, as well as specify allowed gaps between
refills. These approaches would improve clinical utility of
data describing BP persistence and its impact on fracture
risk.},
Doi = {10.1185/030079907X226311},
Key = {fds272822}
}
@article{fds272820,
Author = {Cramer, JA and Gold, DT and Silverman, SL and Lewiecki,
EM},
Title = {A systematic review of persistence and compliance with
bisphosphonates for osteoporosis.},
Journal = {Osteoporosis International : a Journal Established as Result
of Cooperation Between the European Foundation for
Osteoporosis and the National Osteoporosis Foundation of the
Usa},
Volume = {18},
Number = {8},
Pages = {1023-1031},
Year = {2007},
Month = {August},
ISSN = {0937-941X},
url = {http://dx.doi.org/10.1007/s00198-006-0322-8},
Abstract = {UNLABELLED: Fourteen reports utilizing data from
de-identified administrative databases were reviewed.
Studies contained at least one measure of patient
persistence or compliance with bisphosphonates or
bisphosphonates and other anti-osteoporosis medications.
These studies confirm that women with osteoporosis have
suboptimal persistence and compliance rates with
bisphosphonate therapy. INTRODUCTION: This review summarizes
patient persistence and compliance with bisphosphonates for
the treatment of osteoporosis. METHODS: We conducted a
MEDLINE search for the period from January 1998 to May 2006,
using a detailed list of terms related to persistence and
compliance with anti-osteoporosis medications. Studies were
included if they contained at least one measure of
persistence or compliance derived from de-identified
administrative databases containing patient demographics and
prescription information. RESULTS: We reviewed 14 reports,
which described 14 databases. The percentage of patients
persisting with therapy for 1 year ranged from 17.9% to
78.0%. Compliance, assessed as mean medication possession
ratio (MPR), ranged from 0.59 to 0.81. When comparing
compliance with weekly and daily bisphosphonates, the mean
MPR was consistently higher for weekly versus daily therapy
(0.58 to 0.76 versus 0.46 to 0.64 for patients receiving
weekly and daily bisphosphonate therapy respectively).
Persistence was also improved in patients receiving weekly
bisphosphonates, assessed by both length of persistence (194
to 269 days [weekly] and 134 to 208 days [daily]) and
percentage of persistent patients at the end of the
follow-up period (35.7% to 69.7% [weekly] and 26.1% to 55.7%
[daily]). CONCLUSION: Although patients using weekly
bisphosphonate medication follow their prescribed dosing
regimens better than those using daily therapy, overall
compliance and persistence rates were suboptimal.},
Doi = {10.1007/s00198-006-0322-8},
Key = {fds272820}
}
@article{fds272818,
Author = {Gold, DT and Martin, BC and Frytak, JR and Amonkar, MM and Cosman,
F},
Title = {A claims database analysis of persistence with alendronate
therapy and fracture risk in post-menopausal women with
osteoporosis.},
Journal = {Curr Med Res Opin},
Volume = {23},
Number = {3},
Pages = {585-594},
Year = {2007},
Month = {March},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17355739},
Abstract = {OBJECTIVE: To explore the relationship between persistence
with alendronate therapy and fracture rates in women with
postmenopausal osteoporosis. RESEARCH DESIGN AND METHODS:
Claims data from a large US health plan database were used
to examine persistence with therapy in postmenopausal women
followed for 24 months. Persistence was defined as the time
(in days) from the date of first fill to the run-out date of
the last prescription with no lapses > 30 days after
completion of the previous refill. A persistent cohort
(length of persistence > or = 182 days) and a nonpersistent
cohort (length of persistence < 182 days) were defined. The
number of patients with a fracture claim in each cohort was
determined. Cox-proportional hazards regression (HR)
analysis was used to determine significant differences in
fracture rates between the two cohorts. RESULTS: 4769
patients were followed for 24 months. Patients in the
persistent cohort were significantly more likely to receive
a treatment (vs. prevention) dose of alendronate (p = 0.03)
and to be older than 65 years (p = 0.04). There was a trend
toward more fractures in the non-persistent (4.9%) than in
the persistent cohort (3.9%; p = 0.09). When controlled for
other significant factors (including age and previous
fractures) patients in the persistent cohort were 26% less
likely to have a fracture diagnosis claim during the study
period than those in the non-persistent cohort (HR = 0.74;
95% CI, 0.549-0.996; p = 0.045). Prescription fill data are
an indirect measure of medication-taking behavior. The use
of claims data to estimate persistence and identify fracture
events prohibits the establishment of causality between
these two variables. CONCLUSION: Study results demonstrated
that non-persistence with therapy, along with previous
fracture and increasing age, was associated with a greater
risk of fracture.},
Doi = {10.1185/030079906X167615},
Key = {fds272818}
}
@article{fds272819,
Author = {Gold, DT and Silverman, SL},
Title = {Do estrogen or selective estrogen receptor modulators
improve quality of life for women with postmenopausal
osteoporosis?},
Journal = {Current Osteoporosis Reports},
Volume = {5},
Number = {1},
Pages = {3-7},
Year = {2007},
Month = {March},
ISSN = {1544-1873},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17320021},
Abstract = {Osteoporotic fractures result in significant deficits in
health-related quality of life (HRQOL). The accumulation of
deficits resulting from osteoporosis and fractures is now
recognized as a major cause of reduced HRQOL in women after
the menopause and in later life. Some of these same
postmenopausal women may also have deficits in HRQOL related
to vasomotor symptoms during the menopausal transition.
Although estrogen therapy has not been shown to improve
overall HRQOL in late postmenopausal women in randomized,
controlled trials, it may improve menopausal symptoms. In
contrast, selective estrogen receptor modulators (SERMs)
such as raloxifene may increase vasomotor symptoms. Although
estrogen is not indicated for the primary prevention of
osteoporosis, estrogen therapy may be considered for the
postmenopausal woman at risk of osteoporotic fracture who is
symptomatic and who is not at high risk of breast cancer or
cardiovascular events. Raloxifene decreases risk of invasive
breast cancer and may be considered in women at high risk of
breast cancer. Decision making about osteoporosis treatment
should also consider the impact of the treatment on
HRQOL.},
Doi = {10.1007/BF02938616},
Key = {fds272819}
}
@article{fds272815,
Author = {Gold, DT and Solimeo, S},
Title = {Osteoporosis and depression: a historical
perspective.},
Journal = {Current Osteoporosis Reports},
Volume = {4},
Number = {4},
Pages = {134-139},
Year = {2006},
Month = {December},
ISSN = {1544-1873},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17112423},
Abstract = {In the early 1980s, researchers studying osteoporosis noted
that depression was one of the major negative consequences
of bone loss and fractures. These researchers believed that
osteoporosis and fractures occurred first, causing a
reactive depression. Meanwhile, a similar but distinct
psychiatry literature noted that osteoporosis or bone loss
appeared to be an undesirable consequence of major
depression. Here, depression was seen as the causal factor,
and osteoporosis was the outcome. The psychiatric
perspective is more biological, based on the presence of
hypercorticoidism in depressed individuals. Those who
believe that osteoporosis leads to depression point out that
depression is a consequence of many chronic illnesses.
Regardless of the correct causal order, the strong positive
relationship between osteoporosis and depression merits
further clinical and research attention in the
future.},
Doi = {10.1007/s11914-996-0021-6},
Key = {fds272815}
}
@article{fds272816,
Author = {Gold, DT and Safi, W and Trinh, H},
Title = {Patient preference and adherence: comparative US studies
between two bisphosphonates, weekly risedronate and monthly
ibandronate.},
Journal = {Curr Med Res Opin},
Volume = {22},
Number = {12},
Pages = {2383-2391},
Year = {2006},
Month = {December},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17257452},
Abstract = {OBJECTIVES: To determine how patients' preferences for
weekly versus monthly bisphosphonate therapy is influenced
by their knowledge of the medication's proven fracture
efficacy. An additional objective is to determine whether
patient adherence to therapy with weekly risedronate versus
monthly ibandronate is related to patient preferences
Methods: Preference data were collected for weekly versus
monthly bisphosphonate therapy among women currently using
bisphosphonates. In addition, the IMS longitudinal
prescription database was used to evaluate adherence among
patients currently taking weekly risedronate or monthly
ibandronate, using three cohorts: overall sample; new to
osteoporosis therapy; and 6 months after initial market
availability. RESULTS: More patients preferred weekly over
monthly therapy (82% vs. 18% respectively, p < 0.0001) after
receiving information about fracture efficacy differences.
Mean compliance was significantly higher for the overall
sample and the post-market group. Mean persistence for
risedronate versus ibandronate patients was significantly
different (p < 0.0001) for the overall sample (144.3 +/-
55.5 days vs. 100.1 +/- 67.4 days), new to therapy (103.5
+/- 66.4 days vs. 92.1 +/- 65.9 days), and post-market
(104.8 +/- 67.3 days vs. 92.1 +/- 65.9 days). Adherence was
significantly higher (p < 0.0001) in patients taking
risedronate versus ibandronate in all groups (72.7 +/- 26.4%
vs. 52.8 +/- 31.5%, overall sample; 51.7 +/- 31.3% vs. 46.6
+/- 30.7%, new to therapy; 53.0 +/- 32.2% vs. 46.6 +/-
30.7%, post-market). In the persistence analyses, biases
might have occurred due to the methodology of breaking down
the dose of the bisphosphonate the patient received during
the index month, as well as due to the selected refill gap
length. CONCLUSIONS: Patients preferred a weekly dosing
regimen with proven vertebral and non-vertebral fracture
efficacy. A monthly dosing regimen did not increase patient
compliance and persistence with bisphosphonate therapy in
this study. However, patient compliance, persistence and
adherence are complex, and methods to increase adherence
beyond dosing schedules should be further
investigated.},
Doi = {10.1185/030079906X154042},
Key = {fds272816}
}
@article{fds272817,
Author = {Keen, R and Jodar, E and Iolascon, G and Kruse, H-P and Varbanov, A and Mann, B and Gold, DT},
Title = {European women's preference for osteoporosis treatment:
influence of clinical effectiveness and dosing
frequency.},
Journal = {Curr Med Res Opin},
Volume = {22},
Number = {12},
Pages = {2375-2381},
Year = {2006},
Month = {December},
ISSN = {0300-7995},
url = {http://dx.doi.org/10.1185/030079906X154079},
Abstract = {OBJECTIVE: To determine participant preference for weekly
versus monthly bisphosphonate therapy for osteoporosis after
being informed about differences in fracture efficacy.
DESIGN: 20-minute, semi-structured, face-to-face or
telephone interviews. Two bisphosphonate choices were
presented on the basis of block randomization: weekly
therapy with proven efficacy to reduce fracture risk at the
spine and hip, or monthly therapy with proven efficacy to
reduce fracture risk at the spine but not the hip. SUBJECTS:
Women from the UK, Germany, France, Spain and Italy, with
postmenopausal osteoporosis and aged > or = 55 years. Fifty
percent were currently taking a weekly bisphosphonate; 50%
had no history of taking any bisphosphonate. MEASURES: An
efficacy rating scale and an intention-to-use rating scale
were developed for this study. The primary endpoint was
preference for weekly or monthly therapy. Reasons for
preference were recorded. RESULTS: A preference was recorded
for 1248 women (1253 were recruited). More women preferred
weekly to monthly therapy (82% vs. 18%, respectively; p <
0.001). Among women who preferred weekly therapy, efficacy
was the most commonly cited reason (65%). Ninety-two percent
of the total cohort rated the efficacy of the weekly therapy
as 'excellent/good' versus 38% for monthly (p < 0.001).
Sixty-nine percent intended to use weekly bisphosphonates
compared with 34% for monthly (p < 0.001). CONCLUSIONS: When
informed about differences in fracture efficacy in weekly
and monthly bisphosphonates, a significantly greater
proportion (82%) of women preferred a weekly bisphosphonate
with proven fracture efficacy at the spine and hip over a
monthly bisphosphonate with proven fracture efficacy only at
the spine.},
Doi = {10.1185/030079906X154079},
Key = {fds272817}
}
@article{fds272812,
Author = {Gold, DT and Alexander, IM and Ettinger, MP},
Title = {How can osteoporosis patients benefit more from their
therapy? Adherence issues with bisphosphonate
therapy.},
Journal = {The Annals of Pharmacotherapy},
Volume = {40},
Number = {6},
Pages = {1143-1150},
Year = {2006},
Month = {June},
ISSN = {1060-0280},
url = {http://www.ncbi.nlm.nih.gov/pubmed/16735667},
Abstract = {OBJECTIVE: To review the evidence on adherence with
bisphosphonates and evolving dosing strategies for
osteoporosis treatment. DATA SOURCES: Articles were
identified by searching MEDLINE (1975-December 2005) using
the following terms: osteoporosis, postmenopausal, fracture,
adherence, compliance, persistence, drug therapy,
bisphosphonates, alendronate, risedronate, ibandronate, and
zoledronate. Additional data included bibliographies from
identified articles. STUDY SELECTION AND DATA EXTRACTION:
All pertinent English-language articles that discussed
adherence issues in patients with osteoporosis were
included. Both those that reviewed overall issues of
medication adherence in osteoporosis and those that focused
specifically on adherence to bisphosphonates were included,
as were articles that addressed strategies for overcoming
nonadherence. DATA SYNTHESIS: Inadequate diagnosis and
treatment of osteoporosis result in a higher risk of
fractures than is necessary. Even patients who are diagnosed
and beginning treatment often do not persist with their
osteoporosis medication because they perceive their fracture
risk to be low and, given the asymptomatic nature of
osteoporosis, do not experience the benefit of symptom
reduction after taking the drugs. Factors that affect
adherence to osteoporosis therapy include drug costs,
adverse effects, dosing frequency, disease education,
patient follow-up, and patient involvement in treatment
decisions. CONCLUSIONS: By considering and implementing
strategies that can improve adherence and persistence,
primary care providers and pharmacists (via counseling) may
enhance long-term outcomes for patients with
osteoporosis.},
Doi = {10.1345/aph.1G534},
Key = {fds272812}
}
@article{fds272813,
Author = {Weiss, TW and Gold, DT and Silverman, SL and McHorney,
CA},
Title = {An evaluation of patient preferences for osteoporosis
medication attributes: results from the PREFER-US
study.},
Journal = {Current Medical Research and Opinion},
Volume = {22},
Number = {5},
Pages = {949-960},
Year = {2006},
Month = {May},
ISSN = {0300-7995},
url = {http://dx.doi.org/10.1185/030079906X104740},
Abstract = {OBJECTIVE: To evaluate preferences for eight medication
attributes that women may consider when evaluating
prescription osteoporosis medications. RESEARCH DESIGN AND
METHODS: The eligible sample consisted of women aged 50
years or older who responded to the 2003 or 2004
Internet-based National Health and Wellness Survey as being
diagnosed with osteoporosis, considering themselves at risk,
or having a family history of osteoporosis. In this Internet
survey (the PREFER survey), respondents were asked to: (1)
force-rank order the eight attributes from one to eight
according to their preferences and (2) separately rate the
importance of each attribute on a Likert-type scale from 1
(extremely unimportant) to 7 (extremely important). RESULTS:
We collected 999 responses across 3 days from a sample of
3368 women and stopped compiling responses after achieving
sample size targets. Drug effectiveness (e.g., ability to
reduce the risk of fractures) was force ranked as the No. 1
preferred osteoporosis medication attribute by 37% of the
sample. Side effects were force ranked as the No. 1
preferred medication attribute by 36% of the sample. Dosing
frequency, dosing procedure, and formulation (i.e., how the
drug is taken) were each force ranked as No. 1 by 2% or less
of the sample. Drug effectiveness had the highest percentage
of 'extremely important' responses (59%) followed by drug
interactions (53%). Drug effectiveness was the highest-rated
attribute (mean [S.D.] = 6.1 [1.6], median = 7), while
dosing frequency was the lowest-rated attribute (mean [S.D.]
= 4.7 [1.8], median = 5). CONCLUSIONS: In our sample of
women with a diagnosis of osteoporosis or at risk for
osteoporosis, drug effectiveness was the most highly ranked
and rated of eight osteoporosis medication attributes. Side
effects and drug interactions were also highly ranked and
rated. Healthcare providers should consider incorporating
patient preferences for key medication attributes into their
therapeutic decision-making processes.},
Doi = {10.1185/030079906X104740},
Key = {fds272813}
}
@article{fds272810,
Author = {Gold, DT and McClung, B},
Title = {Approaches to patient education: emphasizing the long-term
value of compliance and persistence.},
Journal = {Am J Med},
Volume = {119},
Number = {4 Suppl 1},
Pages = {S32-S37},
Year = {2006},
Month = {April},
url = {http://www.ncbi.nlm.nih.gov/pubmed/16563940},
Abstract = {Approximately 50% of patients with chronic disease do not
obtain optimal clinical benefit from treatment because of
poor compliance with medication regimens. Lack of compliance
is associated with poor clinical outcomes, increased
hospitalizations, lower quality of life, and higher overall
healthcare costs. Although poor compliance and persistence
are common across many disease states, they may be
particularly poor in treatment for asymptomatic chronic
diseases such as osteoporosis. Patient education has been
demonstrated to significantly improve compliance with
medication across a broad range of conditions and disease
severities. In a study in which patients received
educational materials, referral for bone densitometry, and
physician consultation, 67% were compliant with treatment
after 6 months. Patient satisfaction with treatment has been
linked to compliance with therapy; by improving patient care
through fulfilling expectations for physician visits and
providing frequent feedback, the healthcare provider can
dramatically improve compliance. Self-management programs
focusing on day-to-day management of chronic diseases have
been shown to significantly improve heath behaviors and
health status. Regardless of the strategy used, attention
must be directed to identifying the patients least likely to
persist with treatment and to providing the education and
support these patients need to adhere to osteoporosis
therapy.},
Doi = {10.1016/j.amjmed.2005.12.021},
Key = {fds272810}
}
@article{fds272811,
Author = {Weber, TJ and Gold, DT},
Title = {Update on male osteoporosis},
Journal = {Advanced Studies in Medicine},
Volume = {6},
Number = {4},
Pages = {171-181},
Year = {2006},
Month = {April},
ISSN = {1530-3004},
Abstract = {PURPOSE: Fragility fractures are increasingly recognized as
an important cause of morbidity and mortality in men. This
review focuses on the potential causes, means of diagnosis,
and available treatment for male osteoporosis. EPIDEMIOLOGY:
More than 2 million men in the United States have
osteoporosis, and approximately 1 in 5 fractures occur in
men. Moreover, it is estimated that there will be 800 000
hip fractures in men worldwide in 2025, reflecting a greater
rate of increase in men (89%) than that in women (69%).
REVIEW SUMMARY: Male osteoporosis is a multifactorial
disorder with testosterone deficiency, excessive
glucocorticoids, and excess alcohol intake the most commonly
observed causes. Although the lifetime risk of fracture is
lower in men than in women, men have higher mortality rates
after hip and other types of osteoporotic fracture.
Diagnostic assessment of osteoporosis in men generally
should be more comprehensive than that in women, given that
more than half of men will have an identifiable secondary
disorder that contributes to their disease. Treatment with
pharmacologic agents does have favorable effects on bone
mineral density in men, though definitive evidence of
antifracture benefit is lacking to date. TYPE OF AVAILABLE
EVIDENCE: Systematic reviews, prospective cohort studies,
randomized-controlled trials, meta-analyses. GRADE OF
AVAILABLE EVIDENCE: Fair. CONCLUSION: Male osteoporosis is a
common disorder associated with significant morbidity and
mortality. An approach of lifestyle modification,
appropriate nutrition (with calcium/vitamin D), and
selective use of pharmacologic agents appears to confer
skeletal benefit to men similar to that in
women.},
Key = {fds272811}
}
@article{fds272851,
Author = {Gold, DT and Pantos, BS and Masica, DN and Misurski, DA and Marcus,
R},
Title = {Initial experience with teriparatide in the United
States.},
Journal = {Current Medical Research and Opinion},
Volume = {22},
Number = {4},
Pages = {703-708},
Year = {2006},
Month = {April},
ISSN = {0300-7995},
url = {http://www.ncbi.nlm.nih.gov/pubmed/16684431},
Abstract = {Teriparatide has been commercially available in the United
States (US) for over 3 years. This summary spans the early
experience with this therapy. As of December 31, 2005, over
235 000 patients had filled a prescription for teriparatide
world-wide. Data collected from July to December 2004, from
15,000 retail pharmacies in the US, indicated that the mean
age of patients was 67.5 years, and more recent data
collected from January through October 2005 indicated that
90% of patients were female. According to market research
conducted with prescribing physicians from February through
March of 2005, it is estimated that over 80% of patients
receiving prescriptions for teriparatide had already
experienced one or more prior fractures. Since teriparatide
is administered subcutaneously, it is important that
patients receive training on the use of the teriparatide
injection device (i.e., the pen device). Educational
programs are available for those who have been prescribed
teriparatide therapy. Patients may also contact a customer
care program regarding a variety of topics, including pen
device use. Based on patient feedback, design changes have
been implemented in the pen device to facilitate optimal
use. Updates have also been made to the prescribing
information to reflect the post-marketing surveillance
experience. Adverse experiences reported to date have been
consistent with the current product label and with
cumulative teriparatide clinical trial experience. As of
December 31, 2005 no reports of pathology-confirmed
osteosarcoma have been received for individuals who have
been treated with teriparatide, either with the commercially
available drug or in clinical trials. We are unaware of any
reports of osteosarcoma in association with other
preparations of teriparatide, or other peptides of
parathyroid hormone, either in the setting of clinical
trials or from marketed drug experience.},
Doi = {10.1185/030079906X100159},
Key = {fds272851}
}
@article{fds272809,
Author = {Gold, DT and Silverman, S},
Title = {Review of adherence to medications for the treatment of
osteoporosis.},
Journal = {Current Osteoporosis Reports},
Volume = {4},
Number = {1},
Pages = {21-27},
Year = {2006},
Month = {March},
ISSN = {1544-1873},
url = {http://www.ncbi.nlm.nih.gov/pubmed/16527004},
Abstract = {One of the major challenges of successful osteoporosis
management is poor patient adherence to current therapies.
Individuals who are nonadherent have significant
consequences of reduced bone mineral density response,
reduced bone marker suppression, and increased risk for
fracture compared with individuals who are adherent.
Although reducing the dosing interval from daily to weekly
oral bisphosphonates has improved adherence, adherence with
weekly bisphosphonates remains suboptimal. Barriers to
adherence include patient health beliefs, inadequate patient
education and age. Potential solutions include increased
health care provider-patient interaction, and longer times
between doses of medications.},
Doi = {10.1007/s11914-006-0011-8},
Key = {fds272809}
}
@article{fds272808,
Author = {Gold, DT},
Title = {Introduction to osteoporosis: From pathogenesis to
prevention and treatment strategies},
Journal = {American Journal of Obstetrics and Gynecology},
Volume = {194},
Number = {2 SUPPL.},
Pages = {S1-S2},
Publisher = {Elsevier BV},
Year = {2006},
Month = {January},
ISSN = {0002-9378},
url = {http://dx.doi.org/10.1016/j.ajog.2005.08.046},
Doi = {10.1016/j.ajog.2005.08.046},
Key = {fds272808}
}
@article{fds272850,
Author = {Miller, PD and Silverman, SL and Gold, DT and Taylor, KA and Chen, P and Wagman, RB},
Title = {Rationale, objectives and design of the Direct Analysis of
Nonvertebral Fracture in the Community Experience (DANCE)
study.},
Journal = {Osteoporosis International : a Journal Established as Result
of Cooperation Between the European Foundation for
Osteoporosis and the National Osteoporosis Foundation of the
Usa},
Volume = {17},
Number = {1},
Pages = {85-90},
Year = {2006},
Month = {January},
ISSN = {0937-941X},
url = {http://dx.doi.org/10.1007/s00198-005-1915-3},
Abstract = {The experience in randomized placebo-controlled clinical
trials may differ from that in community practice. The
pivotal teriparatide [rhPTH(1-34)] studies were initiated
when few therapeutic options for osteoporosis were
available. The Direct Analysis of Non-Vertebral Fractures in
Community Experience (DANCE) study is a prospective
observational trial designed to examine the occurrence of
nonvertebral fragility fractures in a large, diverse patient
population treated with teriparatide. The occurrence of
clinical vertebral fractures and back pain will also be
examined, as will bone mineral density, bone mineral
content, bone area, safety and tolerability. Subjects will
be followed through a course of teriparatide therapy for up
to 24 months and for an additional 24 months after cessation
of treatment. Therefore, subjects may participate in this
study for up to 48 months. DANCE will provide data on the
effectiveness and tolerability of teriparatide therapy in
clinical practice that will complement the results of
published controlled clinical trials.},
Doi = {10.1007/s00198-005-1915-3},
Key = {fds272850}
}
@article{fds272807,
Author = {Gold, DT},
Title = {Elevated calcium requirements for women and unique
approaches to improving calcium adherence.},
Journal = {The Journal of Reproductive Medicine},
Volume = {50},
Number = {11 Suppl},
Pages = {891-895},
Year = {2005},
Month = {November},
ISSN = {0024-7758},
Abstract = {Recent analyses from the Women's Health Initiative have shed
new light on the importance of adequate calcium and vitamin
D intake to women's bone health. This new information
reveals the need for behavioral change in women's calcium
and vitamin D intake. This is especially important
considering that women, at certain points in their lives
have calcium requirements that significantly increase, not
only with menopause, but with pregnancy, post pregnancy and
lactation. Despite the dissemination of this important
information, women are still not complying with the calcium
requirements. This paper will explore the reasons why women
are not complying with the calcium requirements during their
life course even though they are aware of the
requirements.},
Key = {fds272807}
}
@article{fds272806,
Author = {Brunton, S and Carmichael, B and Gold, D and Hull, B and Kauffman, T and Papaioannou, A and Rasch, R and Stracke, HHG and Truumees, E and Primary
Care Education Consortium, and Texas Academy of Family
Physicians},
Title = {Vertebral compression fractures in primary care:
recommendations from a consensus panel.},
Journal = {Journal of Family Practice},
Volume = {54},
Number = {9},
Pages = {781-788},
Year = {2005},
Month = {September},
Abstract = {Vertebral compression fractures are a relatively common but
often unrecognized consequence of osteoporosis. Back pain is
the typical presenting symptom; patients older than 50 years
with acute back pain should undergo a clinical workup for a
VCF. Primary care clinicians have important roles as
educators about bone health and as providers of
pharmacologic therapies. Additionally, they are critical in
coordinating the multidisciplinary care of a patient with a
VCF. Kyphoplasty and vertebroplasty stabilize a VCF,
increase spinal function, and restore normal daily function.
Both may be performed as an inpatient or outpatient
procedure, as determined by medical necessity. They provide
rapid pain improvement with a low complication rate.
Restoration of the vertebral height is an added benefit of
kyphoplasty. Copyright © 2005 Dowden Health
Media.},
Key = {fds272806}
}
@article{fds272846,
Author = {Gold, DT and Martin, B and Freytak, J and Amonkar, M and Cosman,
F},
Title = {Fracture risk, persistence with therapy, and
gastrointestinal healthcare utilization in a claims analysis
of bisphosphonate therapy for osteoporosis},
Journal = {Mayo Clinic Proceedings},
Year = {2005},
Key = {fds272846}
}
@article{fds272847,
Author = {Silverman, SL and Gold, DT},
Title = {The downward spiral of osteoporosis},
Journal = {Annals of Internal Medicine},
Year = {2005},
Key = {fds272847}
}
@article{fds272848,
Author = {Gold, DT and Alexander, IM and Ettinger, MP},
Title = {How can osteoporosis patients get more out of their
therapy?},
Journal = {American Family Physician},
Year = {2005},
Key = {fds272848}
}
@article{fds272849,
Author = {Gold, DT},
Title = {Profile in gerontology. Linda K. George, Ph.D.: The
subjective side of aging},
Journal = {Contemporary Gerontology},
Year = {2005},
Key = {fds272849}
}
@article{fds272854,
Author = {Roberto, KA and Gold, DT and Yorgason, JB},
Title = {The influence of osteoporosis on the marital relationship of
older couples},
Journal = {Journal of Applied Gerontology},
Volume = {23},
Number = {4},
Pages = {443-456},
Publisher = {SAGE Publications},
Year = {2004},
Month = {December},
ISSN = {0733-4648},
url = {http://dx.doi.org/10.1177/0733464804270856},
Abstract = {Thirty-four older wives and their husbands participated in
interviews about adaptation to the wives' osteoporosis and
its influence on their relationship. For most couples, the
wives' osteoporosis resulted in changes in the structure of
their marital relationship but not the overall quality of
the marriage. Discrepancies in pain perceptions were
associated with lower marital adjustment for wives but not
for husbands. The findings suggest the need to focus on the
dynamics of the marital relationship to understand chronic
illness in late-life families.},
Doi = {10.1177/0733464804270856},
Key = {fds272854}
}
@article{fds272853,
Author = {Gold, DT and Shipp, KM and Pieper, CF and Duncan, PW and Martinez, S and Lyles, KW},
Title = {Group treatment improves trunk strength and psychological
status in older women with vertebral fractures: results of a
randomized, clinical trial.},
Journal = {Journal of the American Geriatrics Society},
Volume = {52},
Number = {9},
Pages = {1471-1478},
Year = {2004},
Month = {September},
ISSN = {0002-8614},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15341548},
Abstract = {OBJECTIVES: To assess whether group exercise and coping
classes reduce physical and psychological impairments and
functional disability in older women with prevalent
vertebral fractures (VFs). DESIGN: Randomized, controlled
trial (modified cross-over) with site as unit of assignment;
testing at baseline and 3, 6, 9, and 12 months. SETTING:
Nine North Carolina retirement communities. PARTICIPANTS:
One hundred eighty-five postmenopausal Caucasian women (mean
age 81), each with at least one VFs. INTERVENTION: The
intervention group had 6 months of exercise (3 meetings
weekly, 45 minutes each) and coping classes (2 meetings
weekly, 45 minutes each) in Phase 1, followed by 6 months of
self-maintenance. The control group had 6 months of health
education control intervention (1 meeting weekly, 45
minutes) in Phase 1, followed by the intervention described
above. MEASUREMENTS: Change in trunk extension strength,
change in pain with activities, and change in psychological
symptoms. RESULTS: Between-group differences in the change
in trunk extension strength (10.68 foot pounds, P<.001) and
psychological symptoms (-0.08, P=.011) were significant for
Phase 1. Changes in pain with activities did not differ
between groups (-0.03, P=.64); there was no change in the
pain endpoint. In Phase 2, controls showed significant
changes in trunk strength (15.02 foot pounds, P<.001) and
psychological symptoms (-0.11, P=.006) from baseline. Change
in pain with activities was not significant (-0.03, P=.70).
During self-maintenance, the intervention group did not
worsen in psychological symptoms, but improved trunk
extension strength was not maintained. CONCLUSION: Weak
trunk extension strength and psychological symptoms
associated with VFs can be improved in older women using
group treatment, and psychological improvements are retained
for at least 6 months.},
Doi = {10.1111/j.1532-5415.2004.52409.x},
Key = {fds272853}
}
@article{fds272852,
Author = {Gold, DT and Silverman, SL},
Title = {Osteoporosis self-management: Choices For Better Bone
Health.},
Journal = {Southern Medical Journal},
Volume = {97},
Number = {6},
Pages = {551-554},
Year = {2004},
Month = {June},
ISSN = {0038-4348},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15255420},
Abstract = {Despite recent pharmacologic advances in the prevention and
treatment of osteoporosis, the disease remains incurable.
Effective disease management ultimately lies in the hands of
the individual patient, who must take responsibility for key
health behaviors related to bone health. One behavior
modification strategy that has proven effective, but which
has not previously been applied to osteoporosis, is
"self-management." This article describes the principals,
evolution, and initial outcomes of a new self-management
program, Choices For Better Bone Health. Choices is a group
education course directed to postmenopausal women who are at
risk or already affected by osteoporosis, and has shown
positive results in early evaluations.},
Doi = {10.1097/00007611-200406000-00007},
Key = {fds272852}
}
@article{fds136840,
Author = {MR Benjamins and MA Musick and DT Gold and LK George},
Title = {Age-related declines in activity level: the relationship
between chronic illness and religious activities.},
Journal = {The journals of gerontology. Series B, Psychological
sciences and social sciences, United States},
Volume = {58},
Number = {6},
Pages = {S377-85},
Year = {2003},
Month = {November},
ISSN = {1079-5014},
Keywords = {Aged • Aging • Cerebrovascular Accident •
Chronic Disease • Female • Hip Fractures •
Humans • Life Change Events* • Male •
Neoplasms • Religion* • Social Behavior •
Social Isolation* • psychology •
psychology*},
Abstract = {OBJECTIVES: When they are faced with major life transitions
such as worsening health, older adults may selectively
withdraw from activities. Because of the importance of
religion to a large proportion of the elderly population,
research is needed to determine whether levels of religious
involvement are affected by serious health problems such as
the onset of a chronic disease. METHODS: Multiple waves of
data from the Duke Established Populations for Epidemiologic
Studies of the Elderly were used to analyze the effects of
five different chronic conditions on two religious
activities: service attendance and religious media use.
RESULTS: Findings show that broken hip, cancer, and stroke
were significantly related to levels of religious
attendance. Furthermore, the combined conditions also
significantly predicted religious attendance, with more
conditions being associated with lower attendance. Neither
the individual or summed conditions were significantly
related to religious media use. DISCUSSION: The study finds
some evidence to support the idea that older adults withdraw
from social activities such as religious involvement when
faced with declining health. In contrast, levels of
religious media use remain stable following the onset of one
or more new chronic conditions.},
Key = {fds136840}
}
@article{fds272890,
Author = {Blazer, DG and Fillenbaum, GG and Gold, DT and Burchett, BM and Hays,
JC},
Title = {APOE epsilon4 as a predictor of subjective quality of life
in a biracial older person community sample.},
Journal = {Journal of Aging and Health},
Volume = {15},
Number = {4},
Pages = {645-660},
Year = {2003},
Month = {November},
ISSN = {0898-2643},
url = {http://www.ncbi.nlm.nih.gov/pubmed/14594022},
Keywords = {African Continental Ancestry Group • Aged •
Alleles • Alzheimer Disease • Apolipoproteins E
• Educational Status • European Continental
Ancestry Group • Female • Genotype • Health
Status* • Humans • Male • Quality of Life*
• Risk Factors • genetics • genetics* •
psychology},
Abstract = {UNLABELLED: The epsilon4 allele of apolipoprotein E (APOE)
has been associated with health-related outcomes that may
adversely affect quality of life (QOL) in older adults. In
the absence of published information, we sought to determine
whether the epsilon4 allele was associated with subjective
QOL across 5 parameters in a community sample of older
adults. DESIGN: Prospective cohort study. SETTING:
Community-based sample of older adults in North Carolina
(Duke site of the Established Populations for Epidemiologic
Studies of the Elderly [Duke EPESE]). PARTICIPANTS:
Self-responding genotyped sample members (n = 1,880) of whom
1,254 provided longitudinal data. MEASUREMENTS: APOE
genotype and five newly constructed, reliable, and valid
measures of subjective QOL derived from the Duke EPESE
questionnaire. The 5 parameters measured were social,
economic, mental and physical health, and functional status.
Control variables included age, gender, race (African
American or White), education and urban/rural residence.
RESULTS: Among those with good baseline QOL, there was no
significant association between the epsilon4 allele and any
of the parameters of subjective QOL in longitudinal
analyses. In controlled longitudinal analysis, older age
women predicted poorer functional status; being African
American, and reporting lower education predicted poorer
subjective economic well-being; and being African American
predicted better self-assessed mental health. CONCLUSIONS:
This study is among the first to explore the association of
the epsilon4 allele with overall QOL. Considered from a
public health perspective, these findings challenge the
uncritical assumption that the presence of this
susceptibility gene in the population implies an excess
burden of poor QOL. The findings do not contradict the
previous association of epsilon4 with Alzheimer's disease
(AD) and other conditions. Such conditions continue to merit
full attention.},
Doi = {10.1177/0898264303256216},
Key = {fds272890}
}
@article{fds272899,
Author = {Benjamins, MR and Musick, MA and Gold, DT and George,
LK},
Title = {Age-related declines in activity level: the relationship
between chronic illness and religious activities.},
Journal = {The Journals of Gerontology. Series B, Psychological
Sciences and Social Sciences},
Volume = {58},
Number = {6},
Pages = {S377-S385},
Year = {2003},
Month = {November},
ISSN = {1079-5014},
url = {http://www.ncbi.nlm.nih.gov/pubmed/14614127},
Abstract = {OBJECTIVES: When they are faced with major life transitions
such as worsening health, older adults may selectively
withdraw from activities. Because of the importance of
religion to a large proportion of the elderly population,
research is needed to determine whether levels of religious
involvement are affected by serious health problems such as
the onset of a chronic disease. METHODS: Multiple waves of
data from the Duke Established Populations for Epidemiologic
Studies of the Elderly were used to analyze the effects of
five different chronic conditions on two religious
activities: service attendance and religious media use.
RESULTS: Findings show that broken hip, cancer, and stroke
were significantly related to levels of religious
attendance. Furthermore, the combined conditions also
significantly predicted religious attendance, with more
conditions being associated with lower attendance. Neither
the individual or summed conditions were significantly
related to religious media use. DISCUSSION: The study finds
some evidence to support the idea that older adults withdraw
from social activities such as religious involvement when
faced with declining health. In contrast, levels of
religious media use remain stable following the onset of one
or more new chronic conditions.},
Doi = {10.1093/geronb/58.6.s377},
Key = {fds272899}
}
@article{fds272912,
Author = {Gold, DT},
Title = {Osteoporosis and quality of life psychosocial outcomes and
interventions for individual patients.},
Journal = {Clinics in Geriatric Medicine},
Volume = {19},
Number = {2},
Pages = {271-vi},
Year = {2003},
Month = {May},
ISSN = {0749-0690},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12916286},
Keywords = {Humans • Osteoporosis • Quality of Life* •
psychology*},
Abstract = {Despite the substantial psychosocial impact of osteoporosis,
little research has evolved in this area. Early reports
conceptualized these nonskeletal problems as psychosocial in
nature, but more recent investigations focus on
health-related quality of life (HRQOL). Multiple HRQOL
instruments have been designed to measure this construct in
people with osteoporosis, and each has its strengths and
weaknesses. Unfortunately, so much investigative energy has
been spent on psychometric testing that these instruments
have not been put to work efficiently to identify problem
areas in HRQOL. It is from such results that interventions
to improve HRQOL will occur.},
Doi = {10.1016/s0749-0690(02)00077-0},
Key = {fds272912}
}
@article{fds272855,
Author = {Long, KM and Sudha, S and Sloane, PD and Gold, DT},
Title = {Staff perceptions of successful management of severe
behavioral problems in dementia special care
units},
Journal = {Dementia},
Volume = {2},
Number = {1},
Pages = {105-124},
Publisher = {SAGE Publications},
Year = {2003},
url = {http://dx.doi.org/10.1177/1471301203002001998},
Abstract = {Factors that promote successful management of persons with
severe behavioral problems in special care units (SCUs) for
dementia were evaluated. Using qualitative data from staff
interviews conducted in 36 nursing home SCUs, the study
examined the relationships among demographic and behavioral
characteristics of 70 residents, management techniques of
the staff, and family participation in the management of
persons with severe behavioral problems. Problem behaviors
were often managed successfully in SCUs, although
unpredictable aggression was particularly difficult to
control and was a common reason for discharge. Use of
multiple non-pharmacological techniques was associated with
a greater likelihood of successful management, and physical
restraints were used as a last resort. SCU staff members
also reported that large, physically aggressive men and
residents with real or suspected psychiatric comorbidity
were especially difficult to manage. Finally, family
involvement and support were critical to resident success
and often buffered against resident discharge. © 2003, Sage
Publications. All rights reserved.},
Doi = {10.1177/1471301203002001998},
Key = {fds272855}
}
@article{fds272892,
Author = {Bonner, FJ and Sinaki, M and Grabois, M and Shipp, KM and Lane, JM and Lindsay, R and Gold, DT and Cosman, F and Bouxsein, ML and Weinstein,
JN and Gallagher, RM and Melton, LJ and Salcido, RS and Gordon,
SL},
Title = {Health professional's guide to rehabilitation of the patient
with osteoporosis.},
Journal = {Osteoporosis International : a Journal Established as Result
of Cooperation Between the European Foundation for
Osteoporosis and the National Osteoporosis Foundation of the
Usa},
Volume = {14 Suppl 2},
Pages = {S1-22},
Year = {2003},
ISSN = {0937-941X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12759719},
Keywords = {Aged • Diet • Exercise Therapy • Female
• Humans • Male • Osteoporosis • Patient
Education • complications • methods •
prevention & control • rehabilitation*},
Doi = {10.1007/s00198-002-1308-9},
Key = {fds272892}
}
@article{fds272874,
Author = {Roberto, KA and Gold, DT},
Title = {Chronic pain in later life women: issues and challenges from
the research literature.},
Journal = {Journal of the American Medical Women'S Association
(1972)},
Volume = {57},
Number = {2},
Pages = {97-99},
Year = {2002},
ISSN = {0098-8421},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11991430},
Keywords = {Aged • Aging* • Databases, Factual* • Female
• Humans • Middle Aged • Pain • Research
Design • Sex Factors • Women's Health* •
physiopathology* • therapy},
Abstract = {Because research on chronic pain in older adults comes from
many disciplines, existing information about geriatric pain
is widely scattered. In order to establish a foundation from
which to construct future research and interventions for
older women and men, we developed a comprehensive,
multidisciplinary database of the chronic pain and aging
literature published between 1990 and 1998. We searched 10
electronic databases that index scientific journals and
found 302 articles that focused on chronic pain in later
life. Given the disproportionately high number of women in
many of the study samples, gender comparisons were not
always statistically feasible. Because a limited number of
studies reported sex differences in older adults, it is
difficult to determine whether older women's experiences
with chronic pain are unique and require special attention
from health care providers or whether the causes,
treatments, and consequences of chronic pain should be
considered universal to the older-population as a
whole.},
Key = {fds272874}
}
@article{fds272873,
Author = {Mendes de Leon and CF and Gold, DT and Glass, TA and Kaplan, L and George,
LK},
Title = {Disability as a function of social networks and support in
elderly African Americans and Whites: the Duke EPESE
1986--1992.},
Journal = {The Journals of Gerontology. Series B, Psychological
Sciences and Social Sciences},
Volume = {56},
Number = {3},
Pages = {S179-S190},
Year = {2001},
Month = {May},
ISSN = {1079-5014},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11316843},
Keywords = {Activities of Daily Living • African Americans •
Aged • Analysis of Variance • Community Networks*
• Disabled Persons • European Continental Ancestry
Group • Family • Female • Geriatric
Assessment • Health Surveys • Humans •
Interpersonal Relations • Linear Models • Male
• North Carolina • Population Surveillance •
Questionnaires • Risk Factors • Social Support*
• psychology • psychology*},
Abstract = {OBJECTIVES: We examined the association of structural and
functional aspects of social relationships with change in
disability, and the degree to which race modifies these
associations. METHODS: Data are from a population-based
sample of 4,136 African Americans and Whites aged > or = 65
living in North CAROLINA: Disability data were collected
during seven consecutive yearly interviews and summarized in
two outcome measures. Measures of social relationships
included five measures representing network size, extent of
social interaction, and specific type of relationships, as
well as instrumental and emotional support. Weighted
proportional odds models were fitted to model disability as
a function of baseline social network and support variables,
and the interaction of each variable with follow-up time.
RESULTS: Network size and social interaction showed
significant negative associations with disability risks,
which did not vary by race, or as a function of time. Social
interaction with friends was associated with a reduced risk
for disability, but social interaction with children or
relatives was not related to disability. Instrumental
support was associated with a significantly increased
disability risk, with a greater adverse effect among Whites
than African AMERICANS: Emotional support was not associated
with disability, but a protective effect for ADL disability
was found after controlling for its intercorrelation with
instrumental support. DISCUSSION: The findings provide
further evidence for the role of social relationships in the
disablement process, although not all types of social
relationships may be equally beneficial. Furthermore, these
associations may be more complex than simple causal effects.
There were few racial differences in the association of
social relationships with disability, with the possible
exception of instrumental support, which may allude to
possible sociocultural differences in the experience of
instrumental support exchanges.},
Doi = {10.1093/geronb/56.3.s179},
Key = {fds272873}
}
@article{fds272881,
Author = {Gold, DT},
Title = {The nonskeletal consequences of osteoporotic fractures.
Psychologic and social outcomes.},
Journal = {Rheumatic Disease Clinics of North America},
Volume = {27},
Number = {1},
Pages = {255-262},
Year = {2001},
Month = {February},
ISSN = {0889-857X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11285999},
Keywords = {Anxiety • Depression • Female • Fractures,
Bone • Humans • Osteoporosis • Quality of
Life* • complications* • etiology • etiology*
• psychology*},
Abstract = {The prevalence of osteoporosis is rising as the population
of the United States and other developed countries ages.
These increasing numbers of people have motivated
pharmaceutical companies to develop and market several
antiresorptive medications that can slow down the bone loss
associated with osteoporosis. Although these are not cures
for this disease, they are an important first step in a
vital ongoing public health effort to prevent osteoporosis
in the future and to manage osteoporosis now. We cannot
expect to remediate the problems caused by this disease if
we attend only to its skeletal implications. Like any other
chronic disease, osteoporosis has significant psychologic
and social consequences. From anxiety and depression to
social withdrawal and isolation, if these problems are left
unresolved, they can have a significant negative impact not
only on health issues but also on overall quality of life.
No quick fixes exist for the numerous ways in which
osteoporosis can transform an autonomous person into a
dependent and hopeless patient. In part, responsibility for
helping this patient rests with the medical community.
Referrals to appropriate providers can improve a patient's
physical and emotional well-being. Physician specialists can
help the patient manage comorbid conditions. Physical and
occupational therapists can teach exercises, home safety,
and safe movement. Social workers can provide a framework
for coping that enables individuals to improve their
interpersonal interactions and minimize stress in their
lives. Nutritionists, pharmacists, nurses, and other health
care professionals can make major contributions to the
quality of life of people with osteoporosis and should be
encouraged to do so. Unfortunately, managed care has set
policies that deprive patients with osteoporosis of the
kinds of care that would be most useful to them. As we have
advocated for the last 15 years, a multidisciplinary
approach offers patients the most positive overall way to
manage osteoporosis. Therefore, new alternatives need to be
examined, alternatives that provide both low-cost and
high-quality care. In the long run, patients who practice
self-management, that is, those who take responsibility for
their own calcium and vitamin D intake, are compliant with
medications, exercise, and practice home safety, and who
have a healthy outlook, can control their osteoporosis. The
most effective intervention for the future may be to teach
individuals how to use self-management strategies so that
they can take charge of their osteoporosis and positively
influence their quality of life.},
Doi = {10.1016/s0889-857x(05)70197-6},
Key = {fds272881}
}
@article{fds136801,
Title = {Roberto, K.A., & Gold, D.T. (2001). The challenges of
chronic pain in later life: A selectively annotated
bibliography. Westport, CT: Greenwood Press.},
Year = {2001},
Key = {fds136801}
}
@article{fds136830,
Title = {Blalock, S.J., Currey, S.S., DeVellis, R.F., DeVellis, B.M.,
Giorgino, K.B., Anderson, J.J.B., Dooley, M.A., & Gold, D.T.
(2000). Effects of educational materials concerning
osteoporosis on women's knowledge, beliefs, and behavior.
American Journal of Health Promotion, 14,
161-169.},
Year = {2001},
Key = {fds136830}
}
@article{fds136831,
Title = {Gold, D.T. (2001). The non-skeletal consequences of
osteoporotic fractures: Psychological and social outcomes.
Rheumatic Disease Clinics of North America, 27,
255-262.},
Year = {2001},
Key = {fds136831}
}
@article{fds136832,
Title = {Mendes de Leon, C.F., Gold, D.T., Glass, T.A., Kaplan, L., &
George, L.K. (2001). Disability as a function of social
networks and support in elderly African-Americans and
whites: the Duke EPESE 1986-1992. Journal of Gerontology:
Social Sciences, 56B, S179-S190.},
Year = {2001},
Key = {fds136832}
}
@article{fds272914,
Author = {Hegarty, V and Burchett, BM and Gold, DT and Cohen,
HJ},
Title = {Racial differences in use of cancer prevention services
among older Americans.},
Journal = {Journal of the American Geriatrics Society},
Volume = {48},
Number = {7},
Pages = {735-740},
Year = {2000},
Month = {July},
ISSN = {0002-8614},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10894310},
Keywords = {African Americans • Aged • Aged, 80 and over
• European Continental Ancestry Group • Female
• Health Services for the Aged • Humans •
Male • Mass Screening • Neoplasms • North
Carolina • Utilization Review • epidemiology
• ethnology • prevention & control* •
statistics & numerical data* • utilization •
utilization*},
Abstract = {CONTEXT: Racial differences in receipt of cancer prevention
services may be related to poorer outcomes for minorities.
Understanding reasons for such differences could help target
appropriate interventions. OBJECTIVES: To determine if
racial differences exist in the use of cancer prevention
services among older blacks and whites and to explore
explanatory factors. DESIGN: Sixth follow-up survey of
probability sample, four-stage stratified household design
with 4,162 at baseline in 1986-1987 and 2,846 surveyed in
1992-1993. SETTING: The Piedmont area of North Carolina.
PARTICIPANTS: At time of follow-up survey in 1992-1993 there
were 1,486 women and 726 men age >70 years, of whom 1,246
were black and 966 were white. MEASUREMENTS: Self-reported
use of Papanicolou (pap) testing, clinical breast
examination, mammography, rectal examination, and fecal
occult blood testing on a regular basis within the last two
years. RESULTS: Compared with older whites, older black
persons are less likely to receive pap test (48.1% black vs
56.6% white, P < .001), clinical breast examination (64.6%
black vs 69.2% white, P < .007), mammography (30.2% black vs
40.5% white, P < .001), rectal examination (50.2% black vs
62.4% white, P < .001), and fecal occult blood testing
(37.5% black vs 46.2% white, P < .001). Effect of race on
receipt of cancer prevention services was not significant
when levels of education, income, and insurance coverage
were considered. CONCLUSION: Racial differences exist in the
use of cancer prevention services among older Americans.
However, these differences are related to educational,
income, and insurance differences between blacks and
whites.},
Doi = {10.1111/j.1532-5415.2000.tb04746.x},
Key = {fds272914}
}
@article{fds272885,
Author = {Shipp, KM and Purse, JL and Gold, DT and Pieper, CF and Sloane, R and Schenkman, M and Lyles, KW},
Title = {Timed loaded standing: a measure of combined trunk and arm
endurance suitable for people with vertebral
osteoporosis.},
Journal = {Osteoporosis International : a Journal Established as Result
of Cooperation Between the European Foundation for
Osteoporosis and the National Osteoporosis Foundation of the
Usa},
Volume = {11},
Number = {11},
Pages = {914-922},
Year = {2000},
ISSN = {0937-941X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11193243},
Keywords = {Aged • Aged, 80 and over • Exercise Test •
Female • Fractures, Spontaneous • Humans •
Muscle Fatigue • Muscle Weakness • Osteoporosis
• Physical Endurance • Reproducibility of Results
• Sensitivity and Specificity • Spinal Fractures
• Weight-Bearing • complications • etiology
• methods • physiology • physiology* •
physiopathology • physiopathology*},
Abstract = {Chronic back tiredness or fatigue is a common complaint of
people who have a history of osteoporotic vertebral
fracture. Trunk muscle endurance has not been studied in
people with vertebral osteoporosis, partly due to the lack
of assessment tools. We developed a measure of combined
trunk and arm endurance suitable for people with vertebral
osteoporosis, timed loaded standing (TLS). TLS measures the
time a person can stand while holding a two-pound dumbbell
in each hand with the arms at 90 degrees of shoulder flexion
and the elbows extended. Intraclass correlation coefficients
(ICCs) for same day inter-trial and six to ten day
test-retest reliability were 0.89 (lower bound 95%
confidence interval [LB 95% CI] 0.79) and 0.84 (LB 95% CI
0.68), respectively, in a sample of 21 older women with no
known osteoporosis. In 127 women with vertebral fractures,
the ICC for same day inter-trial reliability was 0.81 (LB
95% CI 0.75). In a sub-sample of 30 of these women with
vertebral fractures, the six to ten day test-retest
reliability was 0.85 (LB 95% CI 0.75). Moderately strong and
statistically significant (p < or = 0.05) correlations were
found between TLS and sixteen of eighteen measures of
physical impairment and function. Functional reach distance,
gait velocity, MOS-36 Physical Function Subscale, shoulder
flexion strength, and six minute walk distance were most
strongly associated with TLS time. Women with vertebral
fractures who endorsed having back tiredness when standing
and working with the arms in front of the body, sitting to
rest because of back tiredness or pain, and planning rest
periods because of back tiredness or pain had significantly
lower TLS times. TLS is a simple, safe physical performance
measure of combined trunk and arm endurance that
demonstrates acceptable reliability (inter-trial and test-
retest) and concurrent validity.},
Doi = {10.1007/s001980070029},
Key = {fds272885}
}
@article{fds272888,
Author = {Blalock, SJ and Currey, SS and DeVellis, RF and DeVellis, BM and Giorgino, KB and Anderson, JJ and Dooley, MA and Gold,
DT},
Title = {Effects of educational materials concerning osteoporosis on
women's knowledge, beliefs, and behavior.},
Journal = {American Journal of Health Promotion : Ajhp},
Volume = {14},
Number = {3},
Pages = {161-169},
Year = {2000},
ISSN = {0890-1171},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10787768},
Keywords = {Adult • Calcium, Dietary • Exercise • Female
• Health Knowledge, Attitudes, Practice* • Health
Promotion • Humans • North Carolina •
Osteoporosis • Regression Analysis • Teaching
Materials* • methods* • prevention &
control*},
Abstract = {PURPOSE: This study examined the effects of brief written
educational materials on osteoporosis-related knowledge,
beliefs, and behaviors. The study also examined whether
observed effects varied as a function of one's stage in the
precaution adoption process. DESIGN: The study used an
experimental research design. SETTING: Participants were
identified from North Carolina driver's license records.
SUBJECTS: Of the 1476 women in the initial sample, 536
(36.3%) enrolled in the study and 307 completed all
follow-up assessments. INTERVENTION: Participants were
randomly assigned to one of four groups. One group received
an information packet containing general information about
osteoporosis. One group received an action plan packet
containing instructions on how to increase one's level of
exercise and calcium intake. One group received both
packets. The final group received neither packet. MEASURES:
Primary study variables were beliefs related to
osteoporosis, calcium, and exercise; osteoporosis knowledge;
calcium and exercise stage; calcium intake; and exercise
level. RESULTS: Overall, receipt of the information packet
was associated with changes in knowledge and beliefs
(F[18,283] = 2.11, p < .01) irrespective of participants'
stage of change. No effects on behavior were observed.
CONCLUSIONS: These findings suggest that brief written
educational materials can facilitate knowledge and belief
change but that they do not promote behavior change. The
generalizability of these findings is limited by the low
study response rate.},
Doi = {10.4278/0890-1171-14.3.161},
Key = {fds272888}
}
@article{fds272905,
Author = {Gold, DT and Roberto, KA},
Title = {Correlates and consequences of chronic pain in older
adults.},
Journal = {Geriatric Nursing (New York, N.Y.)},
Volume = {21},
Number = {5},
Pages = {270-273},
Year = {2000},
ISSN = {0197-4572},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11035311},
Keywords = {Aged • Bibliometrics* • Chronic Disease •
Humans • Pain* • Research* • physiopathology
• psychology},
Abstract = {Chronic pain is a frequent challenge to older adults' coping
skills. Despite the widespread occurrence of chronic
geriatric pain, no comprehensive body of literature on this
topic exists. Instead, research on chronic pain is scattered
across disciplines and is perceived as inaccessible by
scientists. We completed a comprehensive review and
qualitative analysis of the geriatric chronic pain
literature since 1990 and found 314 articles on this topic
that reported. North American research. Physical, social,
and psychologic variables associated with chronic pain and
the elderly were mentioned in just over half (53%) of the
articles. However, both psychosocial causes and consequences
of chronic pain were understudied. Only 16% of the articles
had social variables (gender, race, and age) as their
primary interest; 27% focused on psychologic or psychiatric
issues, with half including depression as the variable of
interest. An analysis of the articles' content suggests that
research on chronic pain in later life would be
substantially improved if a more structured and
comprehensive approach were used that combined the study of
psychosocial issues with that of physical pain. Researchers
and clinicians with a global understanding of chronic pain
might help improve quality of life for older
adults.},
Doi = {10.1067/mgn.2000.110838},
Key = {fds272905}
}
@article{fds272906,
Author = {Gold, DT and Burchett, BM and Shipp, KM and Pieper, CF and Lyles,
KW},
Title = {Factors associated with self-rated health in patients with
Paget's disease of bone.},
Journal = {Journal of Bone and Mineral Research},
Volume = {14 Suppl 2},
Pages = {99-102},
Year = {1999},
Month = {October},
ISSN = {0884-0431},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10510224},
Keywords = {Aged • Female • Health Status* • Humans
• Male • Osteitis Deformans • Questionnaires
• Self Assessment (Psychology)* • Socioeconomic
Factors • psychology*},
Abstract = {Multiple studies show that poor self-rated health (SRH)
increases the risk of mortality up to 5-fold when compared
to excellent SRH. This powerful association remains even
with objective health status and risk factors controlled.
However, few studies have examined the determinants of SRH,
especially as they relate to specific chronic diseases. Here
we identify personal characteristics and disease-related
attributes that are strongly associated with SRH in a sample
of patients with Paget's disease of bone to determine
whether any factors can be modified. Two thousand people
randomly selected from the Paget Foundation mailing list
received a survey asking for information on demographics,
general health and functioning, and the impact of Paget's
disease. Nine hundred and fifty-eight PD patients returned
the completed survey and answered the question, "How would
you rate your overall health?" Answers ranged from excellent
(1) to poor (5). Ordinary least squares regression was used,
with SRH as the dependent variable, to identify those
variables significantly associated with SRH. The overall
regression model was significant (p = 0.0001; R2 = 0.44).
Age (p = 0. 005), satisfaction with family help (p =
0.0001), number of comorbid conditions (p = 0.0001),
functional limitations (p = 0.0003), disease impact (p =
0.0002), health compared to 5 years ago (p = 0. 0001), and
depressive symptoms (p = 0.012) were significant predictors.
Of these, satisfaction with family help, functional
limitations, disease impact, and depressive symptoms are
potentially modifiable with appropriate interventions.
Future longitudinal studies should examine the effectiveness
of such interventions in improving SRH.},
Doi = {10.1002/jbmr.5650140221},
Key = {fds272906}
}
@article{fds272907,
Author = {Purser, JL and Pieper, CF and Branch, LG and Shipp, KM and Gold, DT and Lyles, KW},
Title = {Spinal deformity and mobility self-confidence among women
with osteoporosis and vertebral fractures.},
Journal = {Aging (Milan, Italy)},
Volume = {11},
Number = {4},
Pages = {235-245},
Year = {1999},
Month = {August},
ISSN = {0394-9532},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10605612},
Keywords = {Aged • Aged, 80 and over • Cross-Sectional Studies
• Female • Humans • Osteoporosis • Self
Concept* • Spinal Curvatures • Spinal Fractures
• complications • complications* •
psychology*},
Abstract = {This study evaluated the direct and indirect effects of
spinal deformity on confidence in mobility among 185 older
women with osteoporosis and vertebral fractures. We
administered multidimensional tests of physical and
psychosocial impairment and function to female residents of
continuing care retirement communities, and used path
analytic regression methods to delineate relationships
between spinal deformity, pain, function and mobility
self-confidence. No direct effect of spinal deformity on
confidence in mobility was observed. However, important
indirect paths mediated by functional limitations were
confirmed. A pattern of indirect effects was observed for a
broad array of impairment-level constructs. These results
support current models of the disablement process that
propose functional limitations as the major pathway to
disability. However, they also suggest that the impact of
impairment-level constructs might be overlooked unless we
evaluate indirect, as well as direct effects, on
disability.},
Doi = {10.1007/BF03339664},
Key = {fds272907}
}
@article{fds272889,
Author = {Bohannon, AD and Hanlon, JT and Landerman, R and Gold,
DT},
Title = {Association of race and other potential risk factors with
nonvertebral fractures in community-dwelling elderly
women.},
Journal = {American Journal of Epidemiology},
Volume = {149},
Number = {11},
Pages = {1002-1009},
Year = {1999},
Month = {June},
ISSN = {0002-9262},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10355375},
Keywords = {African Americans • Aged • European Continental
Ancestry Group • Female • Fractures, Bone •
Humans • North Carolina • Odds Ratio •
Osteoporosis, Postmenopausal • Risk Factors •
complications • epidemiology • ethnology •
ethnology* • etiology • statistics & numerical
data*},
Abstract = {This study determined potential associations of
sociodemographic, lifestyle, health, and drug use factors
known to affect bone metabolism with incident nonvertebral
fractures. The baseline sample consisted of 2,590 female,
nonproxy subjects from the Duke Established Populations for
Epidemiologic Studies of the Elderly, which focuses on five
adjacent counties in the Piedmont area of North Carolina.
Information about potential risk factors was collected
during a baseline in-home interview during 1986-1987.
Subsequent nonvertebral fractures were reported at follow-up
interviews during the annual follow-up periods (1988-1993).
The authors used multivariate analyses in which weighted
data were adjusted for sampling design. After controlling
for other potential confounding sociodemographic, lifestyle,
health, and drug use factors, they found that African
American race (adjusted odds ratio (OR) = 0.43, 95%
confidence interval (CI) 0.31-0.58), age (adjusted OR =
1.04, 95% CI 1.01-1.06), alcohol consumption (adjusted OR =
1.61, 95% CI 1.01-2.57), being underweight (adjusted OR =
1.63, 95% CI 1.13-2.34), cognitive impairment (adjusted OR =
1.67, 95% CI 1.12-2.48), impaired mobility (adjusted OR =
1.15, 95% CI 1.03-1.29), and phenytoin use (adjusted OR =
2.93, 95% CI 1.04-8.30) were associated with first fracture
occurrence. Similar findings were observed for nonhip,
nonvertebral fractures. African Americans were less likely
than Whites to have nonvertebral fractures, and these
differences were not related to lifestyle or health factors
examined in this study.},
Doi = {10.1093/oxfordjournals.aje.a009744},
Key = {fds272889}
}
@article{fds272904,
Author = {Purser, JL and Pieper, CF and Duncan, PW and Gold, DT and McConnell, ES and Schenkman, MS and Morey, MC and Branch, LG},
Title = {Reliability of physical performance tests in four different
randomized clinical trials.},
Journal = {Archives of Physical Medicine and Rehabilitation},
Volume = {80},
Number = {5},
Pages = {557-561},
Year = {1999},
Month = {May},
ISSN = {0003-9993},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10326921},
Keywords = {Ankle Joint • Disability Evaluation* • Female
• Geriatric Assessment* • Hip Joint • Humans
• Male • Middle Aged • Osteoporosis •
Parkinson Disease • Randomized Controlled Trials •
Reproducibility of Results • physiopathology},
Abstract = {OBJECTIVES: (1) To assess the test-retest reliability of
physical performance tests in subject groups with different
levels of impairment and disability, and (2) to assess the
stability of these tests over different time intervals.
DESIGN: Test-retest, repeated measures reliability design.
SETTING: (1) A university's center for aging and research
center, (2) a continuing care retirement community, and (3)
an extended care and rehabilitation center at a Veterans
Affairs medical center. SUBJECTS: Twenty-four
community-dwelling elders, 15 community-dwelling elders with
Parkinson disease, 12 older women with vertebral
osteoporosis and compression fractures, and 14 elderly
nursing home residents. MEASURES: Lower extremity isometric
strength (ankle dorsiflexion, hip abduction), spinal
configuration (thoracic kyphosis, lumbar lordosis),
lumbosacral motion (flexion, extension), and timed measures
of the ability to get in and to get out of bed at a usual
pace. RESULTS: Most of the within-group intraclass
correlation coefficients (ICCs) were good to excellent (.70
to .97). Overall, ICCs for all groups combined were between
.70 and .96, and no decrement in reliability was noted after
controlling for group membership. In addition, no decrement
in the ICC was observed for short (1 day) vs. longer (1
week) intervals of testing. CONCLUSIONS: These
performance-based measures may be used reliably across a
wider range of testing environments and elderly populations
than has been reported.},
Doi = {10.1016/s0003-9993(99)90199-5},
Key = {fds272904}
}
@article{fds272883,
Author = {Koplas, PA and Gans, HB and Wisely, MP and Kuchibhatla, M and Cutson,
TM and Gold, DT and Taylor, CT and Schenkman, M},
Title = {Quality of life and Parkinson's disease.},
Journal = {The Journals of Gerontology. Series A, Biological Sciences
and Medical Sciences},
Volume = {54},
Number = {4},
Pages = {M197-M202},
Year = {1999},
Month = {April},
ISSN = {1079-5006},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10219011},
Keywords = {Activities of Daily Living • Aged • Aged, 80 and
over • Attitude to Health • Cross-Sectional
Studies • Depression • Disabled Persons •
Disease Progression • Female • Forecasting •
Humans • Internal-External Control • Male •
Middle Aged • Motor Skills • Multivariate Analysis
• Parkinson Disease • Quality of Life* •
Regression Analysis • Social Adjustment •
classification • physiology • physiopathology
• psychology • psychology*},
Abstract = {BACKGROUND: People with Parkinson's disease (PD) have a
progressive loss of function eventually leading to severe
disability. Although PD would be expected to have a profound
impact on an individual's psychosocial health, there is
relatively limited research on its psychosocial effect. The
purposes of this study were (a) to examine the relationships
between physical disability, depression, and control beliefs
and quality of life in people with PD and (b) to
characterize how these psychosocial variables differ by
stage of disease. METHODS: Eighty-six individuals from five
stages based on clinical disability, ages 51-87, were
interviewed. Established instruments were used to measure
physical disability, depression, and control beliefs.
Quality of life (QOL) was rated on a 5-point Likert scale.
RESULTS: A multivariable regression model including physical
disability, stage of disease, depression, mastery, and
health locus of control predicted QOL (R2 = 0.48), with
mastery as the only significant predictor (p = .0001). There
were significant differences by PD stage for all variables
(p < .05). CONCLUSIONS: Mastery predicted quality of life in
individuals with PD even when depression and physical
disability were included in the model. Differences in
psychosocial variables by stage of PD suggest that the
psychosocial profile of PD patients may change as the
disease progresses.},
Doi = {10.1093/gerona/54.4.m197},
Key = {fds272883}
}
@article{fds272856,
Author = {Purser, JL and Pieper, CF and Branch, LG and Shipp, KM and Gold, DT and Lyles, KW},
Title = {Spinal deformity and mobility self-confidence among women
with osteoporosis},
Journal = {Aging: Clinical and Experimental Research},
Volume = {11},
Pages = {235-245},
Year = {1999},
Key = {fds272856}
}
@article{fds272857,
Author = {Bohannon, AD and Hanlon, JT and Landerman, LR and Gold, DT and Langlois,
J and Harris, T},
Title = {Relationship between race and other potential risk factors
and nonvertebral fractures in community-dwelling elderly
women},
Journal = {American Journal of Epidemiology},
Volume = {149},
Pages = {1002-1009},
Year = {1999},
Key = {fds272857}
}
@article{fds272878,
Author = {Blalock, SJ and Currey, SS and DeVellis, RF and Anderson, JJ and Gold,
DT and Dooley, MA},
Title = {Using a short food frequency questionnaire to estimate
dietary calcium consumption: a tool for patient
education.},
Journal = {Arthritis Care and Research : the Official Journal of the
Arthritis Health Professions Association},
Volume = {11},
Number = {6},
Pages = {479-484},
Year = {1998},
Month = {December},
ISSN = {0893-7524},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10030180},
Keywords = {Adult • Calcium, Dietary • Diet Surveys •
Female • Humans • North Carolina • Nutrition
Assessment* • Nutrition Physiology • Patient
Education • Questionnaires • Regression Analysis
• Reproducibility of Results • Women's Health
• administration & dosage* • education* •
methods* • standards*},
Abstract = {OBJECTIVE: To develop a short food frequency questionnaire
(FFQ) assessing calcium intake and a prediction equation for
estimating total calcium intake from the short FFQ. METHODS:
Data were collected from 536 women via mailed questionnaires
at 3 time points. Stepwise regression analyses were used to
identify those foods and beverages included in the Black
Health Habits and History Questionnaire (HHHQ) that
explained the most variance in participants' dietary calcium
intake. A prediction equation was developed to estimate
total calcium intake based only on information from the
foods/beverages identified. RESULTS: Calcium obtained from
15 foods/beverages explained 97.2% of the variance in total
calcium intake. The mean absolute difference between total
calcium intake estimated from the 15 foods/beverages and the
full HHHQ was less than 50 mg at each time point.
CONCLUSION: Findings suggest that a short FFQ can provide
estimates of total dietary calcium consumption comparable to
the full Block HHHQ.},
Doi = {10.1002/art.1790110608},
Key = {fds272878}
}
@article{fds272887,
Author = {Landerman, LR and Fillenbaum, GG and Pieper, CF and Maddox, GL and Gold,
DT and Guralnik, JM},
Title = {Private health insurance coverage and disability among older
Americans.},
Journal = {The Journals of Gerontology. Series B, Psychological
Sciences and Social Sciences},
Volume = {53},
Number = {5},
Pages = {S258-S266},
Year = {1998},
Month = {September},
ISSN = {1079-5014},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9750574},
Keywords = {Aged • Disabled Persons • Female • Health
Behavior • Health Services • Health Status •
Humans • Income • Insurance Coverage •
Insurance, Health • Male • United States •
economics • statistics & numerical data •
statistics & numerical data* • utilization},
Abstract = {OBJECTIVES: This study examines the relationship between the
lack of private supplemental health insurance coverage and
the development of disability among adults aged 65 and
older. METHODS: Data are from the baseline and six follow-up
waves of the Duke Established Populations for Epidemiologic
Studies of the Elderly survey (N = 4,000). Discrete-time
hazard models were used to estimate the impact of insurance
coverage and other risk factors on the incidence of
disability among those unimpaired at baseline. RESULTS:
Controlling for education, income, and other potential
confounders, the odds of developing disability were 35-49%
higher among those without private coverage. Insurance
coverage also statistically explained part of the increased
risk of disability among low-income persons. DISCUSSION: The
results indicate that changes in health insurance coverage
as well as in individual behaviors may be needed to reduce
disability generally and disability among the
socioeconomically disadvantaged, in particular.},
Doi = {10.1093/geronb/53b.5.s258},
Key = {fds272887}
}
@article{fds272898,
Author = {Gold, DT and Shipp, KM and Lyles, KW},
Title = {Managing patients with complications of osteoporosis.},
Journal = {Endocrinology and Metabolism Clinics of North
America},
Volume = {27},
Number = {2},
Pages = {485-496},
Year = {1998},
Month = {June},
ISSN = {0889-8529},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9669151},
Keywords = {Depression • Employment • Fractures, Bone •
Humans • Osteoporosis • Pain • Self Concept
• complications* • psychology •
therapy},
Abstract = {This article reviews the impact of osteoporosis on quality
of life. It defines specific impairments and suggests how
best to minimize the impact of osteoporosis on patients'
daily lives. Specific issues such as a spinal deformity,
limitations on activities of daily living, pain,
functionality, social impairment, self esteem, and
depression also are addressed. Finally, a multidisciplinary
team approach to osteoporosis is advocated.},
Doi = {10.1016/s0889-8529(05)70018-9},
Key = {fds272898}
}
@article{fds272886,
Author = {Lyles, KW and Gold, DT and Newton, RA and Parekh, S and Shipp, KM and Pieper, CF and Krishan, R and Carson, CC},
Title = {Peyronie's disease is associated with Paget's disease of
bone.},
Journal = {Journal of Bone and Mineral Research},
Volume = {12},
Number = {6},
Pages = {929-934},
Year = {1997},
Month = {June},
ISSN = {0884-0431},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9169352},
Keywords = {Aged • Alkaline Phosphatase • Dupuytren's
Contracture • Humans • Male • Middle Aged
• Osteitis Deformans • Penile Induration •
Questionnaires • United States • blood •
complications • complications* • enzymology •
epidemiology • etiology},
Abstract = {Peyronie's disease is an idiopathic disorder in which an
inflammatory fibrosis occurs in the tunica albuginea of the
corpora cavernosa which causes the erect penis to become
deformed. Peyronie's disease has a prevalence of 1% in men
over age 50 years. Paget's disease of bone is a chronic
skeletal disease with areas of increased bone turnover
leading to pain, deformity, and in some cases arthritis.
Because of a high rate of Peyronie's disease in subjects in
a Paget's disease industry-sponsored drug trial, we asked
whether there was an association between Peyronie's disease
and Paget's disease of bone. We evaluated 61 men with
Paget's disease attending our clinic for metabolic bone
disease in a tertiary referral hospital, reviewed hospital
records of all men discharged from our three hospitals with
the diagnosis of Peyronie's disease, and mailed a validated
questionnaire about shape of the erect penis to 1500 male
members of the Paget Foundation. In the clinic population of
men with Paget's disease of bone, 51 of 61 (83.6%) reported
having normal erections; 10 patients (16.4%) were impotent.
Sixteen of the 51 men (31.4%) had developed a bend or
deformity in their erect penis which was confirmed by a
urologist's examination to be Peyronie's disease. When the
men with Paget's disease with and without Peyronie's disease
were compared, there was no difference in their ages, years
with Paget's disease, or serum alkaline phosphatase level.
Upon medical record review, 1 patient of 262 (0.4%) with
Peyronie's disease was found to have Paget's disease of
bone. The men with Paget's disease returned their
questionnaires for a response rate of 44.8% and reported
Peyronie's disease with a prevalence of 14.5%. We suggest
that Peyronie's disease is associated with Paget's disease
of bone. Furthermore, we suggest that Peyronie's disease may
be a previously unrecognized complication of Paget's disease
of bone.},
Doi = {10.1359/jbmr.1997.12.6.929},
Key = {fds272886}
}
@article{fds272910,
Author = {Blazer, DG and Hays, JC and Fillenbaum, GG and Gold,
DT},
Title = {Memory complaint as a predictor of cognitive decline: a
comparison of African American and White
elders.},
Journal = {Journal of Aging and Health},
Volume = {9},
Number = {2},
Pages = {171-184},
Year = {1997},
Month = {May},
ISSN = {0898-2643},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10182402},
Keywords = {Activities of Daily Living • African Americans* •
Age Factors • Aged • Cognition Disorders* •
Depression • Educational Status • European
Continental Ancestry Group* • Humans • Memory
Disorders* • North Carolina • Questionnaires
• Sex Factors • epidemiology},
Abstract = {Of a representative, racially mixed community sample of
older adults in North Carolina, 59% of Whites and 49% of
African Americans reported worsening memory. The complaint
about memory was positively correlated with age, depressive
symptomatology, and physical function but not with level of
cognitive function as measured by the Short Portable Mental
Status Questionnaire (SPMSQ) at baseline. In a controlled
analysis of longitudinal data, initial SPMSQ score, age,
African American race, lower education, depressive
symptomatology, and physical deficits at baseline, but not
memory complaint, predicted a decline in cognitive function
as measured by the SPMSQ 3 years later. Whereas African
Americans were less likely to complain of deterioration in
memory, actual decline as measured by the SPMSQ was greater
for African Americans than for Whites.},
Doi = {10.1177/089826439700900202},
Key = {fds272910}
}
@article{fds272858,
Author = {Roberto, KA and Gold, DT},
Title = {Spousal support of older women with osteoporotic pain:
Congruity of perceptions},
Journal = {Journal of Women & Aging},
Volume = {9},
Number = {1-2},
Pages = {17-31},
Publisher = {Informa UK Limited},
Year = {1997},
Month = {January},
url = {http://dx.doi.org/10.1300/J074v09n01_03},
Abstract = {Thirty-four couples were interviewed to assess the congruity
of husbands’ and wives’ perceptions of the wives’
osteoporotic pain and the exchange of instrumental support
within the marital relationship. Moderate correlations were
found between the husbands’ and wives’ ratings of two
specific dimensions of the wives’ pain experience:
interference with daily life and pain severity. Wives who
perceived their pain as more severe but as having a lesser
impact on their personal lives provided the most frequent
help to their husbands. The wives’ pain perceptions were
not predictive of the amount of assistance they perceived
receiving from their spouses. Husbands’ perceptions of
their wives’ pain experience were not predictive of the
frequency of instrumental support they either received from
or gave to their wives. © 1997 by the Women &
Aging.},
Doi = {10.1300/J074v09n01_03},
Key = {fds272858}
}
@article{fds136799,
Title = {Hays, J.C., Gold, D.T., & Pieper, C.F. (1997). Sibling
bereavement in late life. Omega, 35, 25-42.},
Year = {1997},
Key = {fds136799}
}
@article{fds136800,
Title = {Roberto, K.A., & Gold, D.T. (in press). Older families and
chronic health problems: The influence of osteoporosis on
the lives of married couples. In Brubaker, T. (Ed.), Family
relationships in later life, 2nd edition.},
Year = {1997},
Key = {fds136800}
}
@article{fds136827,
Title = {Roberto, K.A., & Gold, D.T. (1997). Spousal support of older
women with osteoporotic pain: Congruity of perceptions.
Journal of Women and Aging, 9, 17-31},
Year = {1997},
Key = {fds136827}
}
@article{fds136828,
Title = {Blazer, D.G., Hays, J.C., Fillenbaum, G.G., & Gold, D.T.
(1997). Memory complaint as a predictor of cognitive
decline: A comparison of African-American and White elders.
Journal of Aging and Health, 9, 171-184.},
Year = {1997},
Key = {fds136828}
}
@article{fds136829,
Title = {Lyles, K.W., Gold, D. T., Newton, R.A., Parekh, S., Shipp,
K.M., Pieper, C.F., Krishan, R., & Carson, CC III (1997).
Peyronie's disease is associated with Paget's disease of
bone. Journal of Bone and Mineral Research, 12,
929-934.},
Year = {1997},
Key = {fds136829}
}
@article{fds272913,
Author = {Gold, DT and Boisture, J and Shipp, KM and Pieper, CF and Lyles,
KW},
Title = {Paget's disease of bone and quality of life.},
Journal = {Journal of Bone and Mineral Research},
Volume = {11},
Number = {12},
Pages = {1897-1904},
Year = {1996},
Month = {December},
ISSN = {0884-0431},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8970891},
Keywords = {Adaptation, Psychological* • Aged • Aged, 80 and
over • Demography • Female • Humans •
Male • Osteitis Deformans* • Patient Satisfaction*
• Quality of Life* • Questionnaires •
Regression Analysis • Social Adjustment* •
psychology},
Abstract = {Little is known about how Paget's disease of bone affects
quality of life. To better understand the relative impact of
factors on quality of life, we mailed a brief survey to 2000
people randomly selected from the Paget's Foundation mailing
list. The sample was geographically stratified to examine
the effects of specialist availability. Nine hundred and
fifty-eight persons responded to the questionnaire (53%
response rate after adjustment for death, incorrect
addresses, and nondeliverable mailings). The sample had
equal proportions of males and females, with a mean age of
74 years (SD = 9.0). Most (97%) were white, with high levels
of education (mean 13 years; SD 3.7) and income (60% earned
more than $20,000 annually). They reported pagetic bone in
the skull (34%), spine (35%), pelvis (49%), and leg (48%).
The most frequently mentioned complications were hearing
loss (37%) and bowed limbs (31%). Comorbidity included
arthritis (64%), hypertension (32%), and heart problems
(28%). Nearly half (47%) reported feelings of depression,
and 42% said that their health was fair or poor. Only 21%
reported that quality of life was very good or excellent. In
multiple partial F-test regression analyses, variables were
divided into four domains (social, psychological, care, and
biomedical). The psychological domain explained 19% of the
variance beyond that explained by all other variables; the
social domain explained 3%, the biomedical domain explained
3% and the care domain explained 1%. The importance of the
psychological aspects of Paget's disease suggests that
treatment protocols should include psychological
intervention to improve quality of life.},
Doi = {10.1002/jbmr.5650111210},
Key = {fds272913}
}
@article{fds272900,
Author = {Hays, JC and Schoenfeld, D and Blazer, DG and Gold,
DT},
Title = {Global self-ratings of health and mortality: hazard in the
North Carolina Piedmont.},
Journal = {Journal of Clinical Epidemiology},
Volume = {49},
Number = {9},
Pages = {969-979},
Year = {1996},
Month = {September},
ISSN = {0895-4356},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8780604},
Keywords = {Activities of Daily Living • Aged • Aged, 80 and
over • Female • Health Status* • Humans
• Male • Mortality* • North Carolina •
Population Surveillance* • Proportional Hazards Models
• Risk-Taking • Rural Population • Survival
Analysis • Urban Population • epidemiology},
Abstract = {We analyzed the first 5 years of surveillance data from the
Established Population for the Epidemiologic Studies of the
Elderly (EPESE) in the Piedmont of North Carolina (n = 4162)
to estimate the effect of a global self-rating of health on
survival. Covariates used in Cox proportional hazard models
included sociodemographic factors, chronic medical
conditions, activities of daily living, use of health
services, health risk behaviors, cognitive function,
affective mood, and negative life events. Adjusted risk of
mortality associated with poor (compared to excellent)
self-ratings of health was significantly elevated among
urban men only. Confounders of the association between
survival and overall health assessment varied widely by
subgroup. Pooled estimates from heterogeneous populations
may mask significant subgroup differences both in the
pattern of variables that mediate crude risk and also in the
magnitude of residual risk of global self-ratings of
health.},
Doi = {10.1016/0895-4356(96)00138-2},
Key = {fds272900}
}
@article{fds272915,
Author = {Gold, DT and Pieper, CF and Westlund, RE and Blazer,
DG},
Title = {Do racial differences in hypertension persist in successful
agers? Findings from the MacArthur Study of Successful
Aging.},
Journal = {Journal of Aging and Health},
Volume = {8},
Number = {2},
Pages = {207-219},
Year = {1996},
Month = {May},
ISSN = {0898-2643},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10160558},
Keywords = {Aged • Aging* • Continental Population Groups
• Demography • Health Status • Humans •
Hypertension • Models, Theoretical • Socioeconomic
Factors • ethnology*},
Abstract = {The objective of this study was to determine whether racial
differences in hypertension in a random sample of
community-dwelling older adults also remained significant in
a sample of successful agers. Data for the random sample of
community-dwelling older adults came from the Duke
University Established Populations for Epidemiologic Studies
of the Elderly (4,162 community-dwelling adults age 65 and
older) and showed strong racial differences in hypertension.
Data for successful agers came from the Duke MacArthur (428
of EPESE respondents in the top 30% in terms of physical,
cognitive, and psychosocial performance). The mean of two
sitting blood pressure measurements was the dependent
variable for both sets of analyses. Independent variables
included demographics and health factors. Using logistic
regression, odds ratios in the Duke EPESE and Duke MacArthur
samples for race were similar (Duke EPESE odds ratio = 1.30;
Duke MacArthur odds ratio = 1.29). Sample size differences
affected statistical significance. However, race differences
in hypertension in older adults appear to be unexplained by
socioeconomic status or other usual explanatory variables.
Even among successful agers, racial differences in
hypertension persist.},
Doi = {10.1177/089826439600800203},
Key = {fds272915}
}
@article{fds272861,
Author = {Gold, DT},
Title = {Introduction.},
Journal = {Gerontologist},
Volume = {36},
Number = {2},
Pages = {224-225},
Year = {1996},
Month = {April},
ISSN = {0016-9013},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1996UL78000013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Doi = {10.1093/geront/36.2.224},
Key = {fds272861}
}
@article{fds272884,
Author = {Blalock, SJ and DeVellis, RF and Giorgino, KB and DeVellis, BM and Gold,
DT and Dooley, MA and Anderson, JJ and Smith, SL},
Title = {Osteoporosis prevention in premenopausal women: using a
stage model approach to examine the predictors of
behavior.},
Journal = {Health Psychology : Official Journal of the Division of
Health Psychology, American Psychological
Association},
Volume = {15},
Number = {2},
Pages = {84-93},
Year = {1996},
Month = {March},
ISSN = {0278-6133},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8681924},
Keywords = {Adult • Calcium, Dietary • Exercise • Female
• Food Habits • Health Behavior* • Health
Education* • Health Knowledge, Attitudes, Practice
• Humans • Internal-External Control • Middle
Aged • Osteoporosis, Postmenopausal • Personality
Assessment • Risk Factors • administration &
dosage • etiology • prevention & control* •
psychology},
Abstract = {The precaution adoption process model was used to examine
the predictors of 2 behaviors recommended to reduce the risk
of developing osteoporosis: calcium consumption and
weight-bearing exercise. A total of 452 premenopausal women
completed a mailed questionnaire assessing stage in the
precaution adoption process and 12 knowledge and attitudinal
variables. Participants were also given an opportunity to
request information about osteoporosis. In all, 11 of the 12
knowledge and attitudinal variables were associated with
calcium stage; 8 were associated with exercise stage.
Information requests were associated with both calcium and
exercise stage. Findings provide substantial support for the
precaution adoption process model and suggest that the model
can be usefully applied in this area to increase
understanding of why many women do not practice behaviors
that could reduce their risk of developing
osteoporosis.},
Doi = {10.1037//0278-6133.15.2.84},
Key = {fds272884}
}
@article{fds272894,
Author = {Gold, DT},
Title = {The clinical impact of vertebral fractures: quality of life
in women with osteoporosis.},
Journal = {Bone},
Volume = {18},
Number = {3 Suppl},
Pages = {185S-189S},
Year = {1996},
Month = {March},
ISSN = {8756-3282},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8777086},
Keywords = {Bone Density • Chronic Disease • Female •
Humans • Osteoporosis, Postmenopausal • Pain
• Quality of Life* • Role • Social Support
• Spinal Fractures • epidemiology •
physiology* • physiopathology • psychology* •
therapy},
Abstract = {Osteoporosis has obvious physical and functional
consequences such as kyphosis, restricted range of motion,
and pain. What are not so obvious are the psychosocial
sequelae that result from this metabolic bone disease. Many
patients in the initial phases of the disease express
substantial anxiety, especially about the possibility of
future fractures and physical deformity. As the disease
progresses, depression can become profound for those who
experience hip or multiple vertebral fractures. The effects
of the chronicity of osteoporosis, its disabling and
disfiguring aspects, and the chronic postural pain that
develops as time passes challenge even the most stable
individuals. In addition, osteoporosis has substantial
impact on interpersonal relationships and social roles. The
dependency created by this disease affects close
relationships, because the patient with osteoporosis cannot
reciprocate in social support. Today's older women find the
restrictions of the disease socially devastating. These
women, unlikely to work in the labor force, took pride in
their roles of housekeeper and cook. Unfortunately, severe
osteoporosis can force women to relinquish even these social
roles, leaving them with no source of self-esteem or
accomplishment. In all, osteoporosis is devastating both
psychologically and socially.},
Doi = {10.1016/8756-3282(95)00500-5},
Key = {fds272894}
}
@article{fds136791,
Title = {Gold DT, Pieper CF, Westlund RE, Blazer DG: Do racial
differences in hypertension persist in successful agers?
Findings from the MacArthur Study of Successful Aging.
Journal of Aging and Health 8: 207-219, 1996.},
Year = {1996},
Key = {fds136791}
}
@article{fds136796,
Title = {Gold DT, Boisture J, Shipp KM, Pieper CF, Lyles KW: Paget's
disease of bone and quality of life. Journal of Bone and
Mineral Research 11: 1897-1903, 1996.},
Year = {1996},
Key = {fds136796}
}
@article{fds136797,
Title = {Gold DT: Continuities and discontinuities in sibling
relationships across the life span. In VL Bengtson (ed),
Adulthood and Aging: Research on Continuities and
Discontinuities, New York: Springer, pp 228-243,
1996.},
Year = {1996},
Key = {fds136797}
}
@article{fds136798,
Title = {Gold DT, Lyles KW, Shipp KM, Harper KD, Drezner MK:
Unexpected consequences of osteoporosis: An evolving basis
for treatment decisions. In Marcus R, Feldman D Kelsey J
(eds): Osteoporosis, San Diego, CA: Academic Press, pp
1089-1096, 1996.},
Year = {1996},
Key = {fds136798}
}
@article{fds136814,
Title = {Gold DT: The clinical impact of vertebral fractures: Quality
of life in women with osteoproosis. Bone 18: 185S-190S,
1996.},
Year = {1996},
Key = {fds136814}
}
@article{fds136824,
Title = {Gold DT: Cross-fertilization of the life course and other
theoretical paradigms: An introduction. The Gerontologist
36: 224-225, 1996.},
Year = {1996},
Key = {fds136824}
}
@article{fds136825,
Title = {Blalock SJ, DeVellis RF, Giorgino KB, DeVellis BM, Gold DT,
Dooley MA, Anderson JJB, Smith SL: Osteoporosis prevention:
Using a stage model approach to examine the predictors of
behavior. Health Psychology 15: 84-93, 1996.},
Year = {1996},
Key = {fds136825}
}
@article{fds136826,
Title = {Hays JC, Schoenfeld D, Blazer DG, Gold DT: Global
self-ratings of health mortality: Hazard in the North
Carolina Piedmont. Journal of Clinical Epidemiology 49:
969-979, 1996.},
Year = {1996},
Key = {fds136826}
}
@article{fds272860,
Author = {Blalock, SJ and DeVellis, RF and Giorgino, KB and DeVellis, BM and Gold,
DT and Dooley, MA and Anderson, JJB and Smith, SL},
Title = {Osteoporosis prevention: Using a stage model approach to
examine the predictors of behavior},
Journal = {Health Psychology},
Volume = {15},
Pages = {84-93},
Year = {1996},
Key = {fds272860}
}
@article{fds272875,
Author = {Hays, JC and Fillenbaum, GG and Gold, DT and Shanley, MC and Blazer,
DG},
Title = {Black-white and urban-rural differences in stability of
household composition among elderly persons.},
Journal = {The Journals of Gerontology. Series B, Psychological
Sciences and Social Sciences},
Volume = {50},
Number = {5},
Pages = {S301-S311},
Year = {1995},
Month = {September},
ISSN = {1079-5014},
url = {http://www.ncbi.nlm.nih.gov/pubmed/7656081},
Keywords = {African Americans* • Aged • Aged, 80 and over
• Educational Status • European Continental
Ancestry Group* • Family Characteristics* • Female
• Humans • Income • Male • Marital
Status • Rural Population* • Urban
Population*},
Abstract = {The dynamic nature of household composition in a population
of elderly persons, with particular focus on Black-White and
urban-rural differences, is described in this study. The
Duke EPESE is a stratified, random household sample (N =
4,162) of elderly persons in a five-county mixed urban-rural
area of North Carolina with respondents contacted annually
to report on health and social factors. Between 1986 and
1990, 35 percent of the households underwent some change in
composition, with 14 percent contracting and/or expanding
more than once. Where elders lived alone and where married
elders lived with the spouse and/or others, Black elders
were significantly more likely to experience a net expansion
of their household than were White elders of the same age,
gender, socioeconomic, and functional status. Elderly
residents of rural areas who lived alone were slightly more
likely to add one or more persons to their households than
were comparable elderly urban residents. No additional risk
of household instability was noted in sociodemographic or
health-related subgroups by race or residence. Future
analyses should examine the outcomes of instability.},
Doi = {10.1093/geronb/50b.5.s301},
Key = {fds272875}
}
@article{fds272903,
Author = {Lyles, KW and Lammers, JE and Shipp, KM and Sherman, L and Pieper, CF and Martinez, S and Gold, DT},
Title = {Functional and mobility impairments associated with Paget's
disease of bone.},
Journal = {Journal of the American Geriatrics Society},
Volume = {43},
Number = {5},
Pages = {502-506},
Year = {1995},
Month = {May},
ISSN = {0002-8614},
url = {http://www.ncbi.nlm.nih.gov/pubmed/7730531},
Keywords = {Activities of Daily Living* • Aged • Alkaline
Phosphatase • Case-Control Studies • Female •
Humans • Male • Osteitis Deformans • Self
Assessment (Psychology) • blood • enzymology
• physiopathology*},
Abstract = {OBJECTIVE: To determine if patients with Paget's disease of
bone involving the tibia, femur, and/or acetabular portion
of the ilium had more impairments in function and mobility
than age- and sex-matched control subjects. PATIENTS AND
METHODS: A case control study with Paget's disease patients
selected from a center for bone disease at a tertiary
medical center; control subjects were volunteers from the
Duke University Aging Center subject registry. Demographic
characteristics, physical examination and serum alkaline
phosphatase levels were obtained. Radiographs of the pelvis
and lower extremities were evaluated by a radiologist. All
participants completed a Functional Status Questionnaire
(FSQ). Mobility measures included mobility skills protocol,
10-foot walk time, 360-degree turn left (number of steps),
and 6-minute walk distance. RESULTS: The 12 Paget's disease
patients were no different in age (70.7 +/- 6.2 years) than
the 12 control subjects (69.5 +/- 6.2 years). Serum alkaline
phosphatase levels were elevated in Paget's patients (539
+/- 530 IU/L), and normal in control subjects (85 +/- 17
IU/L). In addition to Paget's disease, radiographs showed
joint space loss in joints proximate to the diseased bone.
On the FSQ scales Paget's disease patients had significantly
lower scores in basic activities of daily living (P < .05),
instrumental activities of daily living (P < .001), and
social activity than control subjects (P < .05). There was
no difference between the groups on scales measuring mental
health and quality of social interaction. On mobility
measurements, Paget's disease patients showed significant
impairments when compared with control subjects: mobility
skills protocol score (22.5 +/- 2.5 vs 25.6 +/- 0.7, P <
.001); 10-foot walk (3.96 +/- 1.3 vs 2.55 +/- 0.5 seconds, P
< .001); 360 degree turn left (8.0 +/- 1.0 vs 5.9 +/- 0.6
steps, P < .001); and 6-minute walk (342.0 +/- 108.5 vs
519.4 +/- 100 meters, P < .001). CONCLUSION: When compared
with control subjects, patients who have Paget's disease of
bone involving the tibia, femur, or acetabular portion of
the ilium have clinically and statistically significant
functional and mobility impairments compared to age- and
gender-matched controls.},
Doi = {10.1111/j.1532-5415.1995.tb06096.x},
Key = {fds272903}
}
@article{fds136821,
Title = {Lyles, K.W., Lammers, J.E., Shipp, K.M., Sherman, L.,
Pieper, C.F., & Gold, D.T. (1995). Functional and mobility
impairments associated with Paget's Disease of Bone. Journal
of the American Geriatrics Society, 43, 502-506.},
Year = {1995},
Key = {fds136821}
}
@article{fds136822,
Title = {Hays, J.C., Fillenbaum, G.G., Gold, D.T. ,Shanley, M.C., &
Blazer, D.G. (1995). Black-white and urban-rural differences
in stability of household composition among the elderly.
Journal of Gerontology: Social Sciences, 50B,
S301-S311.},
Year = {1995},
Key = {fds136822}
}
@article{fds136823,
Title = {Gold, D.T., & Drezner, M.K. (1995). Osteoporosis and quality
of life: Impact on delivery of care. In B.L. Riggs and L.J.
Melton III (Eds.), Osteoporosis: Etiology, diagnosis, and
management (pp. 475-486), 2nd edition. Philadephia:
Lippincott-Raven Publishers.},
Year = {1995},
Key = {fds136823}
}
@article{fds272862,
Author = {Gold, DT},
Title = {Chronic musculoskeletal pain: Older women and their coping
strategies},
Journal = {Journal of Women & Aging},
Volume = {6},
Number = {4},
Pages = {43-58},
Publisher = {Informa UK Limited},
Year = {1994},
Month = {November},
ISSN = {0895-2841},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994QD29800005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Abstract = {Two diseases, osteoporosis and osteoarthritis, are
responsible for a majority of the chronic musculoskeletal
pain that older women experience. Osteoporosis is the
metabolic bone disease most common in older women and is
responsible for fractures, kyphosis, and chronic pain.
Osteoarthritis, the most commonly diagnosed musculoskeletal
problem in older women, causes degeneration of the
weight-bearing joints in the body, resulting in limited
function and chronic pain. In this paper, these and other
common disorders are briefly described and typical coping
strategies used by older women in pain are reviewed. In
addition, potential multidisciplinary treatment regimens are
discussed. © 1995 by The Haworth Press, Inc. All rights
reserved.},
Doi = {10.1300/J074v06n04_04},
Key = {fds272862}
}
@article{fds272877,
Author = {Schoenfeld, DE and Malmrose, LC and Blazer, DG and Gold, DT and Seeman,
TE},
Title = {Self-rated health and mortality in the high-functioning
elderly--a closer look at healthy individuals: MacArthur
field study of successful aging.},
Journal = {Journal of Gerontology},
Volume = {49},
Number = {3},
Pages = {M109-M115},
Year = {1994},
Month = {May},
ISSN = {0022-1422},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8169332},
Keywords = {African Continental Ancestry Group • Aged • Aging
• Alcohol Drinking • Attitude to Health* •
Chronic Disease • Cohort Studies • European
Continental Ancestry Group • Female • Forecasting
• Health* • Hospitalization • Humans •
Longitudinal Studies • Male • Mortality •
Odds Ratio • Self Concept* • Sex Factors •
Smoking • physiology* • psychology},
Abstract = {BACKGROUND: This study tested the predictive value of
self-rated health on 3-year mortality, with attention
focused on healthy, high-functioning elders. METHODS: Data
from the MacArthur Field Study of Successful Aging were
utilized. Subjects were 70-79-year-old (at baseline)
residents of the communities of East Boston, MA, New Haven,
CT, and a five-county area in and around Durham County, NC
(N = 1192) which comprise three sites of the Established
Populations for Epidemiologic Studies of the Elderly
(EPESE). In-home interviews were conducted in 1988 and 1991.
Logistic regression was performed to create odds ratios
adjusted for age, sex, race, marital status, education,
alcohol consumption, cigarette smoking, chronic diseases,
past hospitalizations, and cognitive function. The sample
was then divided into healthy and less healthy cohorts based
on number of chronic diseases, and the analyses were
repeated. RESULTS: The adjusted odds ratios for self-rated
health (poor/bad ratings compared to excellent ratings) in
relation to mortality were 19.56 in the general sample,
93.51 in the healthy cohort, and 2.75 in the less healthy
cohort. CONCLUSION: Self-rated health is predictive of
mortality in controlled analyses, with the greatest impact
seen in healthy individuals. Health care professionals
should be sensitive to the significance of poor self-rated
health in apparently healthy patients.},
Doi = {10.1093/geronj/49.3.m109},
Key = {fds272877}
}
@article{fds272893,
Author = {Linzer, M and Gold, DT and Pontinen, M and Divine, GW and Felder, A and Brooks, WB},
Title = {Recurrent syncope as a chronic disease: preliminary
validation of a disease-specific measure of functional
impairment.},
Journal = {Journal of General Internal Medicine},
Volume = {9},
Number = {4},
Pages = {181-186},
Year = {1994},
Month = {April},
ISSN = {0884-8734},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8014722},
Keywords = {Activities of Daily Living • Attitude to Health •
Cohort Studies • Female • Health Status •
Humans • Male • Middle Aged • Outcome
Assessment (Health Care)* • Pilot Projects •
Quality of Life • Questionnaires • Recurrence
• Severity of Illness Index • Syncope •
epidemiology* • psychology},
Abstract = {BACKGROUND: A disease-specific measure of functional health
in syncope would provide an important outcome measure for
use either in clinical trials or in the clinical management
of patients with recurrent syncope. METHODS AND
MEASUREMENTS: In a previous study the authors used formal
functional status measures to determine physical and
psychosocial impairment in recurrent syncope. This study
provides a preliminary assessment of a disease-specific
measure of function. The measure was pilot tested on 84
subjects, and validated in a separate cohort of 49 patients.
The measure consists of 1) an 11-question matrix of yes/no
questions, assessing the ways that syncope interferes with a
patient's life (the result is expressed as a proportion of
the total number of ways that syncope might interfere and is
called the Impairment Score), and 2) three Likert-scale
questions that assess the patient's fear and worry about
syncope. Correlations were obtained between scores on the
disease-specific measure and other measures of functional
health. RESULTS: Among the 49 patients in the test cohort,
final scores on the disease-specific measure correlated with
both physical and psychosocial dimension scores on a measure
of functional status, the Sickness Impact Profile (r =
0.35-0.36, p = 0.01), and with five of ten subscale scores
on a measure of psychological distress, the Symptom
Checklist 90-R (r = 0.30-0.43, p = 0.004-0.02). CONCLUSIONS:
This new disease-specific quality-of-life measure in syncope
measures both physical and psychosocial components of
impairment and could be a valuable adjunct in measuring
outcomes in syncope patients.},
Doi = {10.1007/BF02600121},
Key = {fds272893}
}
@article{fds136794,
Title = {Gold DT: Social support in later life. In (ed Manheimer RJ),
Older Americans Almanac. Detroit: Gale Research Inc., pp
359-370, 1994.},
Year = {1994},
Key = {fds136794}
}
@article{fds136795,
Title = {Gold, D.T. (1994). Chronic musculoskeletal pain: Older women
and their coping strategies. Journal of Women and Aging, 6,
43-58.},
Year = {1994},
Key = {fds136795}
}
@article{fds136818,
Title = {Schoenfeld DE, Malmrose LC, Blazer DG, Gold DT, Seeman TE:
Self-rated health and mortality in the high-functioning
elderly--a closer look at healthy individuals: MacArthur
Field Study of Successful Aging. Journal of Gerontology:
Medical Sciences 49: M109-M115, 1994.},
Year = {1994},
Key = {fds136818}
}
@article{fds136819,
Title = {Linzer M, Gold DT, Pontinen M, Divine GW, Felder A, Brooks
WB: Recurrent syncope as a chronic disease: Preliminary
validation of a disease-specific measure of functional
impairment. Journal of Geneal Internal Medicine 9: 181-186,
1994.},
Year = {1994},
Key = {fds136819}
}
@article{fds136820,
Title = {Gold DT: Family relationships in later life. In (Manheimer
RJ) Older Americans Almanac. Detroit: Gale Research Inc., pp
319-342, 1994.},
Year = {1994},
Key = {fds136820}
}
@article{fds272895,
Author = {Lyles, KW and Gold, DT and Shipp, KM and Pieper, CF and Martinez, S and Mulhausen, PL},
Title = {Association of osteoporotic vertebral compression fractures
with impaired functional status.},
Journal = {The American Journal of Medicine},
Volume = {94},
Number = {6},
Pages = {595-601},
Year = {1993},
Month = {June},
ISSN = {0002-9343},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8506884},
Keywords = {Activities of Daily Living • Adult • Aged •
Aged, 80 and over • Case-Control Studies •
Exercise • Female • Fractures, Spontaneous •
Humans • Lumbar Vertebrae • Osteoporosis,
Postmenopausal • Spinal Fractures • Thoracic
Vertebrae • complications • etiology •
injuries • physiopathology* • psychology •
radiography},
Abstract = {PURPOSE: To determine if vertebral compression fractures in
elderly women were associated with impairments in physical,
functional, and psychosocial performance. SUBJECTS AND
METHODS: Ten white women with confirmed vertebral
compression fractures were age- and race-matched with 10
control subjects without fractures in a case-control design.
All subjects invited to participate in this study were
patients of the Geriatrics Division of the Department of
Medicine at Duke University Medical Center. All study
participants lived either in the community or in the
independent-living sections of local retirement communities
in and around Durham, NC. Subjects with fractures (mean age
= 81.9 years, SD = 5.9 years) had two or more vertebral
compression fractures in their medical records, whereas
control subjects (mean age = 79.6 years, SD = 6.5 years) had
no history of vertebral fractures. Spinal radiographs of all
women confirmed group assignment. Physical, functional, and
psychosocial performances were evaluated. Physical
performance was assessed by measurements of maximal trunk
extension torque and thoracic and lumbar spinal motion in
the sagittal plane, functional reach, mobility skills, 10-ft
timed walk, and 6-minute walk test. Thoracic and lumbar
spinal configurations were also determined. Functional
performance was assessed using the Functional Status Index.
Psychosocial performance was assessed with the following
scales: Hopkins Symptom Checklist 90 Revised, Rosenberg
Self-Esteem Scale, West Haven-Yale Pain Inventory, Beck
Depression Inventory, and single-item health-belief
questions. RESULTS: Control subjects were not significantly
different from patients with fractures in age, weight,
number of current illnesses, number of prescribed
medications, number of pain medications, ratings of lumbar
spine degenerative disc disease, or lumbar spine facet joint
arthritis. Activity levels and exercise participation were
similar in both groups. Control subjects had no vertebral
fractures, whereas fracture subjects had 4.2 +/- 2.6
fractures (range: 2 to 10). Thoracic kyphosis was increased
and lumbar lordosis was reduced in fracture subjects.
Fracture subjects had reduced maximal trunk extension
torque, thoracic and lumbar spine sagittal plane motion,
functional reach, mobility skills, and 6-minute walk test.
The Functional Status Index showed reduced levels of
functional performance in fracture subjects compared with
controls with increased levels of assistance, pain with
activity, and difficulty in activities. Psychosocial
performance was limited in fracture subjects with increased
psychiatric symptoms, increased pain, and greater perception
of problems caused by health. CONCLUSION: Vertebral
compression fractures are associated with significant
performance impairments in physical, functional, and
psychosocial domains in older women.},
Doi = {10.1016/0002-9343(93)90210-g},
Key = {fds272895}
}
@article{fds272882,
Author = {Weinberger, M and Gold, DT and Divine, GW and Cowper, PA and Hodgson,
LG and Schreiner, PJ and George, LK},
Title = {Expenditures in caring for patients with dementia who live
at home.},
Journal = {American Journal of Public Health},
Volume = {83},
Number = {3},
Pages = {338-341},
Year = {1993},
Month = {March},
ISSN = {0090-0036},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8438969},
Keywords = {Aged • Caregivers • Dementia • Female •
Health Expenditures* • Home Care Services • Home
Nursing • Humans • Male • Middle Aged •
economics* • therapy*},
Abstract = {OBJECTIVES: Given the national interest in progressive
dementia, we estimated expenditures incurred in caring for
dementia patients who live at home. METHODS: Primary
caregivers of 264 patients from a university-based memory
disorders clinic were interviewed at baseline and asked to
keep service use diaries for 6 months; 141 caregivers who
returned the diaries are the focus of this report. We
examined both formal and informal services (distinguished by
whether money was exchanged) and associated expenditures.
RESULTS: Neither caregivers returning diaries nor their
patients differed at baseline from those not returning
diaries and their patients. Expenditures incurred over 6
months were extensive for both formal ($6986) and informal
($786) services. Out-of-pocket expenditures were high (e.g.,
in-home companion or sitter, adult day care, visiting
nurse). Multivariable analyses indicated that patients with
more severe symptoms of dementia and families with higher
incomes reported significantly higher expenditures.
CONCLUSIONS: The expense of caring for patients with
progressive dementia living at home may be higher than
previously estimated and frequently involves expenses paid
directly by patients and their families.},
Doi = {10.2105/ajph.83.3.338},
Key = {fds272882}
}
@article{fds272908,
Author = {Hays, JC and Blazer, DG and Gold, DT},
Title = {CES-D: cutpoint or change score?},
Journal = {Journal of the American Geriatrics Society},
Volume = {41},
Number = {3},
Pages = {344-345},
Year = {1993},
Month = {March},
ISSN = {0002-8614},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8440864},
Keywords = {Aged • Bereavement* • Depression • Female
• Humans • Male • Risk Factors •
diagnosis*},
Doi = {10.1111/j.1532-5415.1993.tb06718.x},
Key = {fds272908}
}
@article{fds272909,
Author = {Weinberger, M and Gold, DT and Divine, GW and Cowper, PA and Hodgson,
LG and Schreiner, PJ and George, LK},
Title = {Social service interventions for caregivers of patients with
dementia: impact on health care utilization and
expenditures.},
Journal = {Journal of the American Geriatrics Society},
Volume = {41},
Number = {2},
Pages = {153-156},
Year = {1993},
Month = {February},
ISSN = {0002-8614},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8426038},
Keywords = {Aged • Caregivers* • Delivery of Health Care
• Dementia • Educational Status • Evaluation
Studies • Family • Female • Humans •
Income • Male • Marriage • Middle Aged •
Social Work* • economics • therapy* •
utilization*},
Abstract = {OBJECTIVES: An intervention, which had as its primary goal
the enhancement of compliance to social work
recommendations, was shown to produce extremely high rates
of compliance. This report addresses the secondary objective
of the study: to evaluate the impact of the intervention on
short-term (ie, 6-month) health services utilization and
expenditures. DESIGN: Randomized controlled trial. SETTING:
University-based memory disorders clinic. PARTICIPANTS:
Caregivers of patients with progressive memory disorders.
MAIN OUTCOME MEASURES: Service utilization and expenditures.
RESULTS: The intervention did not have a statistically
significant impact on utilization of either health care or
community resources. The intervention group had $903 less
expenditures during the study period, a difference that did
not achieve statistical significance. The results were
consistent when controlling for caregiver characteristics
that differed at baseline. CONCLUSIONS: Although the
intervention was successful in enhancing compliance with
recommendations, more intensive interventions may be
required to increase subsequent service utilization. Future
investigations may wish to target the appropriateness of
services used over a period longer than 6
months.},
Doi = {10.1111/j.1532-5415.1993.tb02050.x},
Key = {fds272909}
}
@article{fds272871,
Author = {Gold, DT and Stegmaier, K and Bales, CW and Lyles, KW and Westlund, RE and Drezner, MK},
Title = {Psychosocial functioning and osteoporosis in late life:
Results of a multidisciplinary intervention},
Journal = {Journal of Women'S Health},
Volume = {2},
Number = {2},
Pages = {149-155},
Publisher = {MARY ANN LIEBERT, INC},
Year = {1993},
Month = {January},
url = {http://dx.doi.org/10.1089/jwh.1993.2.149},
Abstract = {Objective: To determine whether older women and men with
osteoporosis who participated in a medica. evaluation
program showed improvement in psychosocial functioning when
compared to a age-, gender-, and disease severity-matched
group of osteoporotic patients who did not participate in
this program. Design: A prospective clinical investigation
of older women and men with osteoporosis. A pretest-posttest
design was used with intervention patients compared to
patients receiving usual care. Setting: Bone Metabolism
Clinic and Duke University Preventive and Therapeutic
Program for Osteoporosis (DUPATPO), at Duke University
Medica. Center. Participants: One hundred and three
community-dwelling older adults (mean age = 67 years; 91
women and 12 men) who had registered for treatment of
osteoporosis at the Duke University Bone Metabolism Clinic.
All 43 patients who enrolled in DUPATPO between July 1988
and April 1989 were recruited for this study. In addition,
60 comparison patients from the Bone Clinic population who
had not been offered DUPATPO participation were also
enrolled. Intervention: DUPATPO, a four-day initial program
with multidisciplinary team including endocrinologists,
geriatricians, physical therapists, nutritionists, and other
support personnel. After the initial program of education,
exercise, and nutritional counseling, patients were seen at
three-month intervals for the next year. Comparison patients
received usual care (a consult appointment with an
endocrinologist with possible referral to physical therapy).
Main Outcome Measures: Short Psychiatric Evaluation Scale
(stress symptoms), the Rosenberg Self-Esteem Scale
(self-esteem), and the Hopkins Symptom Checklist 90-Revised
(psychiatric symptoms). Results: No significant differences
on primary outcome measures at baseline were found between
intervention and comparison patients. At 60-day follow-up,
however, analyses of variance showed significant differences
in stress symptoms (P = 0.021) and general psychiatric
symptoms (P = 0.002). A multivariate analysis of variance
using the SCL-90-R subscales as outcomes (e.g., depression,
hostility) showed overall significance (P = 0.04).
Significant differences were seen on the somatization (P =
0.026), obsessive-compulsive (P = 0.003), and anxiety (P =
0.002) dimensions. Conclusions: This study demonstrates that
psychosocial functioning of older women and men can be
improved with multidisciplinary intervention.},
Doi = {10.1089/jwh.1993.2.149},
Key = {fds272871}
}
@article{fds136792,
Title = {Weinberger, M., Gold, D.T., Divine, G.W., Cowper, P.A.,
Hodgson, L.G., Schreiner, P.J., & George, L.K. (1993).
Expenditures in caring for patients with dementia. American
Journal of Public Health, 83, 338-341.},
Year = {1993},
Key = {fds136792}
}
@article{fds136793,
Title = {Gold, D.T., & Schmader, K. (1993). An introduction to aging.
In R. Michaels (Ed.), Psychiatry Revised edition (pp. 1-18).
Philadelphia: J.B. Lippencott Company.},
Year = {1993},
Key = {fds136793}
}
@article{fds136813,
Title = {Gold, D.T., Stegmaier, K., Bales, C.W., Lyles, K.W.,
Westlund, R.E., & Drezner, M.K. (1993). Psychosocial
functioning and osteoporosis in late life: Results of a
multidisciplinary intervention. Journal of Women's Health,
2, 149-155.},
Year = {1993},
Key = {fds136813}
}
@article{fds136815,
Title = {Weinberger, M., Gold, D.T., Divine, G.W., Cowper, P.A.,
Hodgson, L.G., Schreiner, P.J., & George, L.K. (1993).
Social service interventions for caregivers of patients with
dementia: Impact on health care utilization and
expenditures. Journal of the American Geriatrics Society,
41, 153-156.},
Year = {1993},
Key = {fds136815}
}
@article{fds136816,
Title = {Lyles, K.W., Gold, D.T., Shipp, K.M., Pieper, C.F.,
Martinez, S., & Mulhausen, P.L. (1993). Association of
osteoporotic vertebral compression fractures with impaired
functional status. American Journal of Medicine, 94,
595-601.},
Year = {1993},
Key = {fds136816}
}
@article{fds136817,
Title = {Gold DT, Stegmaier K, BalesCW, Lyles KW, Westlund RE,
Drezner MK: Psychosocial functioning and osteoporosis in
late life: Results of a multidisciplinary intervention.
Journal of Women's Health 2: 149-155, 1993.},
Year = {1993},
Key = {fds136817}
}
@article{fds272863,
Author = {Weinberger, M and Gold, DT and Divine, GW and Cowper, PA and Hodgson,
LG and Schreiner, PJ and George, LK},
Title = {Expenditures in caring for patients with
dementia},
Journal = {American Journal of Public Health},
Volume = {83},
Pages = {338-341},
Year = {1993},
Key = {fds272863}
}
@article{fds272901,
Author = {Weinberger, M and Saunders, AF and Bearon, LB and Gold, DT and Brown,
JT and Samsa, GP and Loehrer, PJ},
Title = {Physician-related barriers to breast cancer screening in
older women.},
Journal = {Journal of Gerontology},
Volume = {47 Spec No},
Pages = {111-117},
Year = {1992},
Month = {November},
ISSN = {0022-1422},
url = {http://www.ncbi.nlm.nih.gov/pubmed/1430872},
Keywords = {Aged* • Attitude of Health Personnel* • Breast
Neoplasms • Costs and Cost Analysis • Female
• Humans • Mammography • Mass Screening*
• Patient Compliance • Physicians* •
economics • methods • prevention &
control*},
Abstract = {Despite evidence that annual mammographic screening in women
50 years and older reduces mortality, surveys of physicians
and patients have repeatedly demonstrated that annual
screening mammography is not performed. The fundamental
question addressed in this chapter is: If the assumption is
made that the scientific evidence supports the use of
mammography, what, then, are physician-related barriers to
mammographic screening of elderly women? Using a model that
classifies barriers to implementing prevention protocols
into three categories (predisposing, enabling, and
reinforcing factors), literature is reviewed to help
identify reasons for low mammographic screening rates,
especially in elderly women. This article concludes with a
discussion of strategies that may help overcome barriers to
mammographic screening in elderly women.},
Key = {fds272901}
}
@article{fds272902,
Author = {Gold, DT and Sloane, PD and Mathew, LJ and Bledsoe, MM and Konanc,
DA},
Title = {Special care units: a typology of care settings for
memory-impaired older adults.},
Journal = {Gerontologist},
Volume = {31},
Number = {4},
Pages = {467-475},
Year = {1991},
Month = {August},
ISSN = {0016-9013},
url = {http://www.ncbi.nlm.nih.gov/pubmed/1909986},
Keywords = {Aged • Alzheimer Disease • Humans • Long-Term
Care • Nursing Homes • Quality of Health Care
• United States • classification* •
organization & administration* • therapy*},
Abstract = {After rating 55 nursing homes in five states, we created a
typology of care settings that included eight distinct types
of units designed to care for memory-impaired older adults.
SCUs appeared to be associated with higher quality care than
were traditional units, although quality of SCU care was not
uniformly outstanding. This typology provides guidelines
that can be used in preresidential analysis of prospective
care units for demented older adults.},
Doi = {10.1093/geront/31.4.467},
Key = {fds272902}
}
@article{fds272891,
Author = {Gold, DT and Smith, SD and Bales, CW and Lyles, KW and Westlund, RE and Drezner, MK},
Title = {Osteoporosis in late life: does health locus of control
affect psychosocial adaptation?},
Journal = {Journal of the American Geriatrics Society},
Volume = {39},
Number = {7},
Pages = {670-675},
Year = {1991},
Month = {July},
ISSN = {0002-8614},
url = {http://www.ncbi.nlm.nih.gov/pubmed/2061532},
Keywords = {Adaptation, Psychological* • Aged • Analysis of
Variance • Female • Health Status • Humans
• Male • Osteoporosis • Psychosocial
Deprivation* • Self Concept • Stress,
Psychological • etiology • psychology* •
therapy},
Abstract = {Osteoporosis, a metabolic bone disease most prevalent in
older adults, is a major public health problem. Although
management of osteoporosis through diet, exercise, and
medication has improved, little is known about the
psychosocial consequences of this disabling disease. In an
attempt to identify patient characteristics that would
provide physicians with insight into appropriate management
styles for older osteoporotics, we assessed 103 patients
with osteoporosis for their health locus of control (HLOC)
orientation. We examined the relationship between HLOC and
patient outcomes after participation in the Duke University
Preventive and Therapeutic Program for Osteoporosis
(DUPATPO) to determine whether HLOC was associated with
functioning after program participation. More specifically,
we asked whether internal or external HLOC was associated
with decreases in depression, psychiatric symptoms, and
stress symptoms, or with increases in self-esteem, exercise,
and disease knowledge. We have shown in our earlier work
(Gold et al, J Am Geriatr Soc 1989; 37:417) that program
participation is associated with improved functioning in
older adults. We now asked whether knowledge of a patient's
HLOC would help predict these improvements. A comparison
group (ie, older osteoporotics who did not participate in
DUPATPO) was also assessed for HLOC to examine the possible
association between HLOC and health behaviors regardless of
the DUPATPO intervention. Our findings indicate that HLOC
provided little useful information regarding patient
outcomes. Although improvements were seen in the mental
health of program participants, no association between these
improvements and HLOC could be found.},
Doi = {10.1111/j.1532-5415.1991.tb03620.x},
Key = {fds272891}
}
@article{fds272876,
Author = {Anscher, MS and Gold, DT},
Title = {Literacy and laryngectomy: how should one treat head and
neck cancer in patients who cannot read or
write?},
Journal = {Southern Medical Journal},
Volume = {84},
Number = {2},
Pages = {209-213},
Year = {1991},
Month = {February},
ISSN = {0038-4348},
url = {http://www.ncbi.nlm.nih.gov/pubmed/1990455},
Keywords = {Attitude of Health Personnel • Data Collection •
Educational Status* • Head and Neck Neoplasms •
Humans • Laryngectomy* • North Carolina •
Patient Care Planning • Quality of Life • Reading
• Specialties, Medical • Writing • psychology
• therapy*},
Abstract = {The entire population of otolaryngologists and radiation
oncologists (N = 192) in active practice in the state of
North Carolina were surveyed to assess their level of
awareness of illiteracy among adults in the United States
and to determine whether these physicians consider
illiteracy in the treatment decision process for patients
with head and neck cancer. Excluding respondents who did not
treat patients with head and neck cancer and physicians
practicing outside of the state of North Carolina, the
response rate was 115 of 182, or 63%. Only 26% of
respondents were able to estimate correctly the prevalence
of illiteracy in the US adult population. Forty-one percent
of respondents, however, stated that they did consider their
patient's ability to read and/or write before making
treatment recommendations for head and neck cancer. This
survey and accompanying literature review suggest that
physicians perceive illiteracy as a problem that may have a
significant impact on patients with head and neck cancer,
but lack the data needed to enable them to quantify the
effect of illiteracy on treatment outcome. The study
reported is the first step in examining ways in which
illiteracy might negatively affect patient
outcomes.},
Key = {fds272876}
}
@article{fds272865,
Author = {Bales, CW and Gold, DT},
Title = {Nutrition education for osteoporosis patients: An innovative
approach to care of the chronically ill elderly},
Journal = {Journal of Nutrition Education},
Volume = {23},
Number = {3},
Pages = {120-127},
Publisher = {Elsevier BV},
Year = {1991},
Month = {January},
ISSN = {0022-3182},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1991FT16700005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Doi = {10.1016/S0022-3182(12)80488-2},
Key = {fds272865}
}
@article{fds272911,
Author = {Weinberger, M and Saunders, AF and Samsa, GP and Bearon, LB and Gold,
DT and Brown, JT and Booher, P and Loehrer, PJ},
Title = {Breast cancer screening in older women: practices and
barriers reported by primary care physicians.},
Journal = {Journal of the American Geriatrics Society},
Volume = {39},
Number = {1},
Pages = {22-29},
Year = {1991},
Month = {January},
ISSN = {0002-8614},
url = {http://www.ncbi.nlm.nih.gov/pubmed/1987253},
Keywords = {Aged • Breast Neoplasms • Family Practice •
Female • Gynecology • Health Knowledge, Attitudes,
Practice* • Humans • Indiana • Internal
Medicine • Male • Mammography • Mass
Screening • Middle Aged • Obstetrics •
Physician's Practice Patterns • Primary Health Care
• Questionnaires • Risk Factors • adverse
effects • epidemiology • prevention & control*
• radiography • standards •
standards*},
Abstract = {Annual mammography, in combination with clinical breast
examinations, can reduce mortality from breast cancer.
However, surveys of both patients and physicians suggest
that mammography is underutilized. This study examined
whether physicians' reported breast cancer screening
practices and barriers to mammography varied with patients'
age. Data from 576 primary care physicians (internal
medicine, family/general practice, and obstetrics/gynecology)
who participated in a mailed statewide survey were analyzed.
Physicians reported screening elderly women significantly
less often than younger women, regardless of family history
of breast cancer. With the exception of medical specialty,
physicians' demographic and practice characteristics were
not associated with reported screening practices. However,
physicians' knowledge and beliefs about breast cancer in
older women were associated with reported screening
practices. When analyzing barriers to ordering mammography,
cost to the patient was viewed as a barrier for women of all
ages, and pain was viewed as a greater barrier for younger
women; otherwise, physicians consistently believed that
their elderly patients faced considerably more barriers
compared with younger women. Further investigation is
required to examine why primary care physicians report
age-related differences in both breast screening and
barriers to mammography.},
Doi = {10.1111/j.1532-5415.1991.tb05901.x},
Key = {fds272911}
}
@article{fds272864,
Author = {Linzer, M and Pontinen, MA and Gold, DT and Divine, GW and Felder, A and Brooks, WB},
Title = {Impairment of physical and psychosocial health in recurrent
syncope: Defining a new chronic disease},
Journal = {Journal of Clinical Epidemiology},
Volume = {44},
Pages = {1037-1043},
Year = {1991},
Key = {fds272864}
}
@article{fds272866,
Author = {George, LK and Gold, DT},
Title = {Life Course Perspectives on Intergenerational and
Generational Connections},
Journal = {Marriage and Family Review},
Volume = {16},
Number = {1-2},
Pages = {67-88},
Publisher = {Informa UK Limited},
Year = {1991},
url = {http://dx.doi.org/10.1300/J002v16n01_04},
Doi = {10.1300/J002v16n01_04},
Key = {fds272866}
}
@article{fds272867,
Author = {Anscher, M and Gold, DT},
Title = {Head and neck cancer: Should literacy play a part in
treatment decisions?},
Journal = {Southern Medical Journal},
Volume = {84},
Pages = {209-213},
Year = {1991},
Key = {fds272867}
}
@article{fds272896,
Author = {Linzer, M and Pontinen, M and Gold, DT and Divine, GW and Felder, A and Brooks, WB},
Title = {Impairment of physical and psychosocial function in
recurrent syncope.},
Journal = {Journal of Clinical Epidemiology},
Volume = {44},
Number = {10},
Pages = {1037-1043},
Year = {1991},
ISSN = {0895-4356},
url = {http://www.ncbi.nlm.nih.gov/pubmed/1940996},
Keywords = {Activities of Daily Living* • Female • Health
Status • Humans • Male • Middle Aged •
Psychosocial Deprivation* • Questionnaires •
Recurrence • Severity of Illness Index • Syncope
• etiology • physiopathology •
psychology*},
Abstract = {Physical and psychosocial function have rarely been assessed
in syncope. We used two valid and reliable measures of
health status, the Sickness Impact Profile (SIP) and the
Symptom Checklist 90 (SCL-90-R), to assess functional
impairment in 62 patients with recurrent syncope seen in a
syncope specialty clinic. Mean total SIP scores were
markedly elevated at 17 (SD = 14), indicating a level of
impairment similar to severe rheumatoid arthritis and
chronic low back pain. SIP psychosocial scores were
significantly greater than SIP physical scores (20 vs 11, p
less than 0.0001). SCL-90-R scores were also high,
comparable to those of psychiatric inpatients. Somatization,
anxiety and depression dimensions of the SCL-90-R were
particularly elevated. SCL-90-R subscale scores were highly
correlated with SIP psychosocial scores (all r greater than
0.4, and p less than 0.001). Neither age nor number of
comorbid diseases correlated with measures of psychosocial
function, suggesting that syncope itself causes psychosocial
impairment. Although this was a referral population, these
data suggest that function can be seriously impaired by
syncope, that the degree of impairment is similar to that
reported in other chronic diseases, and that syncope leads
to significantly greater psychosocial than physical
impairment.},
Doi = {10.1016/0895-4356(91)90005-t},
Key = {fds272896}
}
@article{fds272916,
Author = {Gold, DT},
Title = {Late-life sibling relationships: does race affect
typological distribution?},
Journal = {Gerontologist},
Volume = {30},
Number = {6},
Pages = {741-748},
Year = {1990},
Month = {December},
ISSN = {0016-9013},
url = {http://www.ncbi.nlm.nih.gov/pubmed/2286332},
Keywords = {African Americans • Aged • Aged, 80 and over
• Chi-Square Distribution • European Continental
Ancestry Group • Female • Humans • Logistic
Models • Male • Sibling Relations • Social
Support • United States • ethnology* •
psychology*},
Abstract = {Using a typology of sibling relationships in old age (Gold,
1989a), effects of race on distribution of relationships
were studied. Differences between elderly white and black
sibling pairs on several dimensions were also examined.
Analyses of interview data suggest that race is
systematically related to distribution, but that other
demographic variables do not significantly affect the
distribution of dyads among categories in the typology.
Using log linear models, it was shown that the interaction
between race, type, and dyadic gender composition was
significant. Data also suggest that black dyads are
represented more frequently in the positive categories, and
white dyads are more likely to be categorized as "apathetic"
or "hostile."},
Doi = {10.1093/geront/30.6.741},
Key = {fds272916}
}
@article{fds272872,
Author = {Gold, DT and Woodbury, MA and George, LK},
Title = {Relationship classification using grade of membership
analysis: a typology of sibling relationships in later
life.},
Journal = {Journal of Gerontology},
Volume = {45},
Number = {2},
Pages = {S43-S51},
Year = {1990},
Month = {March},
ISSN = {0022-1422},
url = {http://www.ncbi.nlm.nih.gov/pubmed/2313052},
Keywords = {Aged • Aging • Attitude • Cohort Studies
• Emotions • Female • Hostility • Humans
• Jealousy • Male • Marriage • Sibling
Relations* • Social Behavior • Social Class •
Social Support • psychology*},
Abstract = {The results of a comparison of two typologies of sibling
relationships in old age are reported. Both analyses rely on
the same data collected in individual interviews with adults
over the age of 65. The first typology was constructed using
constant comparative analysis; the second relied on the
grade of membership (GOM) technique. This is the first time
GOM has been used to create a taxonomy of human
relationships based on psychosocial variables. The two
typologies are compared in terms of number of types
generated, the characteristics of each type, factors
influencing typological construction, and the utility of
empirical results. Implications for additional use of the
GOM technique to study late-life sibling relations are
discussed.},
Doi = {10.1093/geronj/45.2.s43},
Key = {fds272872}
}
@article{fds136812,
Title = {Gold, D.T., Woodbury, M.A., & George, L.K. (1990).
Relationship classification using Grade of Membership (GOM)
analysis: A typology of sibling relationships in later life.
Journal of Gerontology, 45, S43-S51.},
Year = {1990},
Key = {fds136812}
}
@article{fds272897,
Author = {Gold, DT and Lyles, KW and Bales, CW and Drezner,
MK},
Title = {Teaching patients coping behaviors: an essential part of
successful management of osteoporosis.},
Journal = {Journal of Bone and Mineral Research},
Volume = {4},
Number = {6},
Pages = {799-801},
Year = {1989},
Month = {December},
ISSN = {0884-0431},
url = {http://www.ncbi.nlm.nih.gov/pubmed/2610017},
Keywords = {Adaptation, Psychological* • Calcium, Dietary •
Exercise Therapy • Humans • Osteoporosis •
Patient Education* • psychology* • therapeutic use
• therapy},
Doi = {10.1002/jbmr.5650040602},
Key = {fds272897}
}
@article{fds272868,
Author = {GOLD, DT},
Title = {Generational Solidarity},
Journal = {American Behavioral Scientist},
Volume = {33},
Number = {1},
Pages = {19-32},
Publisher = {SAGE Publications},
Year = {1989},
Month = {September},
ISSN = {0002-7642},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1989AR16200002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Doi = {10.1177/0002764289033001003},
Key = {fds272868}
}
@article{fds272879,
Author = {Gold, DT and Bales, CW and Lyles, KW and Drezner,
MK},
Title = {Treatment of osteoporosis. The psychological impact of a
medical education program on older patients.},
Journal = {Journal of the American Geriatrics Society},
Volume = {37},
Number = {5},
Pages = {417-422},
Year = {1989},
Month = {May},
ISSN = {0002-8614},
url = {http://www.ncbi.nlm.nih.gov/pubmed/2703639},
Keywords = {Adaptation, Psychological • Aged • Calcium,
Dietary • Chronic Disease • Depression •
Female • Follow-Up Studies • Humans • Male
• Middle Aged • Osteoporosis • Patient
Education • Social Support • Stress, Psychological
• administration & dosage • etiology •
methods* • psychology • psychology* •
therapy},
Abstract = {Participants in a therapeutic program for osteoporosis were
studied to determine if program participation improved
psychological outcomes. The 4-day program included intensive
education about the disease and its prognosis, physical
therapy education, nutritional counseling, and medical
evaluation and treatment. All therapeutic patients enrolled
in the program over a one-year period (N = 38) were
interviewed individually pre- and post-participation.
Knowledge of osteoporosis, level of social support, coping
styles, and perceptions of the impact of pain and chronicity
were assessed. Patients reported improved future outlook
despite continued concern about pain and chronicity. Mention
of depression was reduced, and knowledge of osteoporosis
increased significantly. In addition, there were meaningful
changes in patients' understanding of disease management.
These included knowing when to make specific changes and
avoid harmful actions. The findings suggest that an
educational program can have a positive impact on patients'
coping. Educational efforts may be an important component in
the management of chronic disease.},
Doi = {10.1111/j.1532-5415.1989.tb02637.x},
Key = {fds272879}
}
@article{fds315575,
Author = {Binstock, RH and Gold, DT},
Title = {Home or Institutional Care: Which is Better?},
Journal = {Gerontologist},
Volume = {29},
Number = {6},
Pages = {840-843},
Publisher = {Oxford University Press (OUP)},
Year = {1989},
Month = {January},
ISSN = {0016-9013},
url = {http://dx.doi.org/10.1093/geront/29.6.840},
Doi = {10.1093/geront/29.6.840},
Key = {fds315575}
}
@article{fds326039,
Author = {Gold, DT and Gwyther, LP},
Title = {The Prevention of Elder Abuse: An Educational
Model},
Journal = {Family Relations},
Volume = {38},
Number = {1},
Pages = {8-8},
Publisher = {JSTOR},
Year = {1989},
Month = {January},
url = {http://dx.doi.org/10.2307/583602},
Doi = {10.2307/583602},
Key = {fds326039}
}
@article{fds272869,
Author = {Gold, DT and Gwyther, LP},
Title = {The prevention of elder abuse: An educational
curriculum},
Journal = {Family Relations},
Volume = {38},
Pages = {5-14},
Year = {1989},
Key = {fds272869}
}
@article{fds272880,
Author = {Gold, DT},
Title = {Sibling relationships in old age: a typology.},
Journal = {International Journal of Aging & Human Development},
Volume = {28},
Number = {1},
Pages = {37-51},
Year = {1989},
ISSN = {0091-4150},
url = {http://www.ncbi.nlm.nih.gov/pubmed/2707894},
Keywords = {Aged • Emotions • Female • Gender Identity
• Humans • Interviews • Male •
Personality • Self Concept • Sibling Relations*
• psychology*},
Abstract = {Sibling interactions in old age have received limited
attention in social science literature. This article
examines the different kinds of relationships which exist
between siblings in old age and the ways in which each type
meets or ignores the social and psychological needs of older
people. Five types of sibling relationships emerged from
data collected in open-ended, exploratory interviews with
thirty men and thirty women over the age of sixty-five who
had at least one living sibling. Each type reflects a
discrete pattern of instrumental support, emotional support,
and contact, as well as a different degree of closeness,
envy, resentment, approval, and involvement with the
sibling. The distribution of same-sex and cross-sex dyads
among the types suggests gender differences in sibling
interactions based on the gender composition of the sibling
dyad rather than on the gender of the respondent.},
Doi = {10.2190/VGYX-BRHN-J51V-0V39},
Key = {fds272880}
}
@article{fds272870,
Author = {Gold, DT},
Title = {Siblings in Old Age: Something Special},
Journal = {Canadian Journal on Aging Revue Canadienne Du
Vieillissement},
Volume = {6},
Number = {3},
Pages = {199-216},
Publisher = {Cambridge University Press (CUP)},
Year = {1987},
Month = {January},
url = {http://dx.doi.org/10.1017/S0714980800008424},
Abstract = {This paper reports the findings of a qualitative examination
of sibling relationships in old age. Interviews with sixty
people over the age of sixty-five revealed that interactions
with sisters and brothers took on new meaning in late life.
A shared history of lifetime experiences made the sibling
relationship unique in social networks in old age. Those who
had positive relationships with siblings found that
interactions decreased feelings of loneliness, provided
emotional support and validation of earlier life
experiences, and built feelings of closeness and sibling
solidarity. Even those who had negative sibling
relationships indicated a shift in feelings. The intensity
of feeling about siblings in old age suggests that further
study of the later-life sibling bond might increase
understanding of ways in which the social and emotional
needs of older people can be met. Interviews provided an
effective method for gathering rich data about these complex
social and emotional interactions. © 1987, Canadian
Association on Gerontology. All rights reserved.},
Doi = {10.1017/S0714980800008424},
Key = {fds272870}
}
@article{fds319302,
Author = {Dawson, MP and Hollingsworth, JW},
Title = {Osteoporosis.},
Journal = {The Journal of the Kentucky Medical Association},
Volume = {71},
Number = {8},
Pages = {503-506},
Year = {1973},
Month = {August},
Key = {fds319302}
}
%% Books
@book{fds39214,
Author = {Roberto, K.A. and Gold, D.T.},
Title = {The challenges of chronic pain in later life: A selectively
annotated bibliography},
Publisher = {Westport, CT: Greenwood Press},
Year = {2001},
Key = {fds39214}
}
%% Book Chapters
@misc{fds362493,
Author = {Gold, DT},
Title = {Condition still critical: Compliance and persistence with
osteoporosis medications},
Pages = {1695-1707},
Booktitle = {Marcus and Feldman’s Osteoporosis},
Year = {2020},
Month = {January},
ISBN = {9780128130735},
url = {http://dx.doi.org/10.1016/B978-0-12-813073-5.00072-1},
Abstract = {Despite multiple efforts at changing patient and provider
behaviors to improve the use of pharmacologic medication for
osteoporosis, the rates of compliance and persistence are
still below desirable levels. This is a multifaceted problem
that stems from a lack of knowledge, poor patient-provider
communication, and powerful fears of the side effects of
osteoporosis medications in general. This chapter covers
issues of compliance and persistence as well as the ways in
which osteoporosis causes or exacerbates psychosocial
problems, including depression. Previous attempts to modify
patient behavior in compliance and persistence have
consistently failed, even though they have been well
designed and based on the literature. I suggest here that
cognitive reframing of osteoporosis in the minds of both
patients and providers is essential to overcoming problems
brought about by the media, the Internet, and websites that
contain false information, and the poor educational efforts
most patients receive.},
Doi = {10.1016/B978-0-12-813073-5.00072-1},
Key = {fds362493}
}
@misc{fds341557,
Author = {Silverman, SL and Gold, DT},
Title = {Adherence to osteoporosis therapies},
Pages = {593-596},
Booktitle = {Primer on the Metabolic Bone Diseases and Disorders of
Mineral Metabolism},
Year = {2018},
Month = {January},
ISBN = {9781119266563},
url = {http://dx.doi.org/10.1002/9781119266594.ch78},
Abstract = {Osteoporosis therapies reduce the risk of osteoporotic
related fractures. Patients with poor persistence to
osteoporosis medications are nonpersistent with nutritional
interventions such as calcium or with medications such as
statins for other asymptomatic diseases. Historically,
optimizing compliance with all osteoporosis therapies has
been challenging, especially with the oral bisphosphonates
which require shorter dosing intervals and more complex
regimens. When injectable osteoporosis medications
administered by a health care provider became available many
thought that persistence would improve because medication
administration would be managed by the health care
professional. Researchers have sought for over a decade to
explain nonpersistence with osteoporosis medications.
Patient perception of risk/benefit is influenced by both
perceived and actual side effects. Many side effects such as
gastrointestinal adverse events lower the likelihood of
persistence. Many patients believe that osteoporotic
fractures are a natural consequence of aging rather than the
manifestation of a chronic and treatable
disease.},
Doi = {10.1002/9781119266594.ch78},
Key = {fds341557}
}
@misc{fds347045,
Author = {Gold, DT},
Title = {Patients who do not take their osteoporosis medications: Can
we help them become compliant?},
Pages = {239-253},
Booktitle = {The Duration and Safety of Osteoporosis Treatment: Anabolic
and Antiresorptive Therapy},
Year = {2015},
Month = {January},
ISBN = {9783319236384},
url = {http://dx.doi.org/10.1007/978-3-319-23639-1_17},
Abstract = {Patients with chronic diseases frequently do not take their
medications correctly. People with osteoporosis are no
exception. Epidemiologic data show that noncompliance and
nonpersistence should be serious concerns for healthcare
professionals who treat this disease. Challenges to having
patients improve their medication behaviors include complex
dosing regimens, perceived and real side effects, cost and
uncertainty about the severity of this disease, and the need
for medication. We have developed a substantial literature
about noncompliance, and many different interventions have
been tested, but behavioral changes are minor and usually
fleeting. Understanding why patients with osteoporosis
refuse to comply with their medication regimens can help
healthcare professionals create and test interventions to
improve medication behaviors and reduce fractures that can
result from noncompliance and nonpersistence with
osteoporosis medicines.},
Doi = {10.1007/978-3-319-23639-1_17},
Key = {fds347045}
}
@misc{fds326329,
Author = {Gold, DT},
Title = {Compliance and Persistence with Osteoporosis
Medications},
Pages = {448-454},
Booktitle = {Primer on the Metabolic Bone Diseases and Disorders of
Mineral Metabolism: Eighth Edition},
Publisher = {JOHN WILEY & SONS INC},
Year = {2013},
Month = {July},
ISBN = {9781118453889},
url = {http://dx.doi.org/10.1002/9781118453926.ch54},
Abstract = {This chapter reviews five key controversies about research
into compliance and persistence with osteoporosis
treatments, and provides supporting evidence about those
controversies. All researchers who study compliance and
persistence with osteoporosis medications agree on one
issue: compliance and persistence with osteoporosis
medications are dismal. Currently, medication possession
ratio (MPR) is the most commonly used measure of compliance.
Significant empirical evidence illustrates the problems we
face in helping patients remain compliant and persistent
with osteoporosis medications regardless of delivery system
or dose duration.},
Doi = {10.1002/9781118453926.ch54},
Key = {fds326329}
}
@misc{fds365804,
Author = {Gold, DT and Silverman, SL},
Title = {Adverse Health Outcomes in Men with Osteoporosis},
Pages = {395-401},
Booktitle = {Osteoporosis in Men: The Effects of Gender on Skeletal
Health},
Year = {2009},
Month = {November},
ISBN = {9780123746023},
url = {http://dx.doi.org/10.1016/B978-0-12-374602-3.00032-8},
Abstract = {The evidence about men and osteoporosis has changed over the
last 30 years. Recent data suggest that at least 20% of
people with osteoporosis are men. That means that 2 million
men or more already have osteoporosis and another 12 million
are at risk of the disease. As life expectancy in the USA
continues to rise, osteoporosis prevalence in men will
increase. In light of these changing demographics, a better
understanding of the incidence and gender-specific
consequences of osteoporosis in men is needed. This chapter
reviews research findings from the last decade that
specifically illuminate the adverse outcomes of osteoporosis
and consequent fractures in men. These outcomes include, but
are not limited to, physical morbidity, psychosocial
outcomes (including health-related quality of life) and
mortality. Although the empirical evidence about men and
their osteoporosis outcomes is somewhat limited, some recent
studies have begun to help researchers understand what
happens when men with osteoporosis experience fractures. ©
2010 Copyright},
Doi = {10.1016/B978-0-12-374602-3.00032-8},
Key = {fds365804}
}
%% Chapters in Books
@misc{fds39236,
Author = {Gold, D.T. and Silverman, S.L.},
Title = {The Downward Spiral of Vertebral Osteoporosis:
Consequences},
Publisher = {Los Angeles, CA: Cedars-Sinai Medical Center},
Year = {2003},
Key = {fds39236}
}
@misc{fds39233,
Author = {Gold, D.T. and Lee, L.S. and Tresolini, C.P.},
Title = {Working With Patients to Prevent, Treat, and Manage
Osteoporosis: A Curriculum Guide for the Health
Professions},
Series = {3rd edition},
Publisher = {Durham, NC: Center for the Study of Aging and Human
Development, Duke University Medical Center},
Year = {2001},
Key = {fds39233}
}
@misc{fds39234,
Author = {Gold, D.T.},
Title = {The impact of osteoporosis on quality of
life},
Journal = {Osteoporosis Management Today},
Volume = {3},
Pages = {3-8},
Year = {2001},
Key = {fds39234}
}
@misc{fds39232,
Author = {Tresolini, C.P. and Gold, D.T. and Lee, L.S.},
Title = {Working With Patients to Prevent, Treat, and Manage
Osteoporosis: A Curriculum Guide for the Health
Professions},
Series = {2nd edition},
Publisher = {San Francisco, CA: National Fund for Medical
Education},
Year = {1998},
Key = {fds39232}
}
@misc{fds39231,
Author = {Tresolini, C.P. and Gold, D.T. and Lee, L.S.},
Title = {Working With Patients to Prevent, Treat, and Manage
Osteoporosis: A Curriculum Guide for the Health
Professions},
Publisher = {San Francisco, CA: National Fund for Medical
Education},
Year = {1996},
Key = {fds39231}
}
@misc{fds39230,
Author = {Roberto, K.A. and Gold, D.T.},
Title = {Osteoporotic Women: Coping with Chronic Pain},
Publisher = {Durham: Center for the Study of Aging and Human Development,
Duke University Medical Center},
Year = {1995},
Key = {fds39230}
}
@misc{fds39229,
Author = {Roberto, K.A. and Gold, D.T.},
Title = {Meeting the Challenge: Coping with Osteoporosis and Chronic
Pain},
Publisher = {Greeley, CO: University of Northern Colorado Gerontology
Program},
Year = {1994},
Key = {fds39229}
}
@misc{fds39239,
Author = {Hays, J.C. and Blazer, D.G. and Gold, D.T.},
Title = {CES-D: Cutpoint or change score?},
Journal = {Journal of the American Geriatrics Society},
Volume = {41},
Pages = {345-346},
Year = {1993},
Key = {fds39239}
}
@misc{fds39228,
Author = {George, L.K. and Gold, D.T.},
Title = {Easing Caregiver Burden: An Intervention to Overcome
Barriers to Service Utilization},
Publisher = {Durham, NC: Center for the Study of Aging and Human
Development},
Year = {1990},
Key = {fds39228}
}
@misc{fds39226,
Author = {D.T. Gold},
Title = {Siblings in old age: Their roles and responsibilities},
Booktitle = {Issues in Aging Monograph No. 1},
Publisher = {Chicago, IL: Center for Applied Gerontology},
Year = {1987},
Key = {fds39226}
}
@misc{fds39225,
Author = {Gold, D.T.},
Title = {Sibling relationships in retrospect: A study of reminiscence
in old age},
Journal = {Dissertation Abstracts International},
Volume = {47},
Pages = {2274A},
Year = {1986},
Key = {fds39225}
}
%% Book Reviews
@article{fds39224,
Author = {Gold, D.T.},
Title = {Review of "Preventing and Managing Osteoporosis" (Gueldner,
Burke, & Smiciklas-Wright, Eds.)},
Journal = {Journal of Women and Aging},
Volume = {13},
Pages = {85-87},
Year = {2001},
Key = {fds39224}
}
@article{fds39222,
Author = {Gold, D.T. and Lyles, K.W.},
Title = {Review of "Treating People with Chronic Disease: A
Psychological Guide" (Goodheart & Lansing)},
Journal = {Contemporary Gerontology},
Volume = {4},
Pages = {92-93},
Year = {1998},
Key = {fds39222}
}
@article{fds39223,
Author = {Gold, D.T.},
Title = {Review of "The Meanings of Age: Selected Writings of Bernice
L. Neugarten" (Neugarten, Ed.)},
Journal = {Contemporary Gerontology},
Volume = {4},
Pages = {136-137},
Year = {1998},
Key = {fds39223}
}
@article{fds39221,
Author = {Gold, D.T.},
Title = {Review of "Sibling Relationships Across the Life Span"
(Cicirelli)},
Journal = {Contemporary Gerontology},
Volume = {3},
Pages = {20-21},
Year = {1996},
Key = {fds39221}
}
@article{fds39220,
Author = {Gold, D.T.},
Title = {Review of "The Changing Contract Across Generations"
(Bengtson & Achenbaum)},
Journal = {Contemporary Gerontology},
Volume = {1},
Pages = {47-49},
Year = {1994},
Key = {fds39220}
}
@article{fds39219,
Author = {Gold, D.T.},
Title = {Review of "Health Care for Older Women" (George &
Ebrahim)},
Journal = {Journal of Women and Aging},
Volume = {5},
Pages = {115-117},
Year = {1993},
Key = {fds39219}
}
@article{fds39217,
Author = {Gold, D.T.},
Title = {Review of "The Social Psychology of Health" (Spacapan &
Oskamp)},
Journal = {Contemporary Sociology},
Volume = {19},
Pages = {120-121},
Year = {1990},
Key = {fds39217}
}
@article{fds39218,
Author = {Gold, D.T.},
Title = {Review of "Uneasy Endings" (Shield) and "Unending Work and
Care" (Corbin & Strauss) in A Home or institutional care:
Which is better?@ (Book review essay)},
Journal = {Gerontologist},
Volume = {29},
Pages = {840-843},
Year = {1989},
Key = {fds39218}
}
| |
Duke University * Arts & Sciences * Faculty * Staff * Grad * Postdocs * Reload * Login | ||
