Publications of Jenna A. McHenry    :chronological  alphabetical  combined listing:

%% Journal Articles   
@article{fds368529,
   Author = {Vyas, N and McHenry, JA},
   Title = {Physiological state gates sensorimotor cortical processing
             and goal-directed behavior.},
   Journal = {Neuron},
   Volume = {110},
   Number = {24},
   Pages = {4037-4039},
   Year = {2022},
   Month = {December},
   url = {http://dx.doi.org/10.1016/j.neuron.2022.11.013},
   Abstract = {Goal-directed behavior is often studied under food- and
             water-restricted states. A study by Matteucci
             et al.<sup>1</sup> in this issue of Neuron reveals that
             task performance and sensorimotor cortical encoding are
             impaired under both low and high motivational states but
             improve with physiological adaption.},
   Doi = {10.1016/j.neuron.2022.11.013},
   Key = {fds368529}
}

@article{fds363459,
   Author = {McHenry, JA},
   Title = {Adolescent sleep molds adult social preferences.},
   Journal = {Nature neuroscience},
   Volume = {25},
   Number = {7},
   Pages = {841-843},
   Year = {2022},
   Month = {July},
   url = {http://dx.doi.org/10.1038/s41593-022-01103-8},
   Doi = {10.1038/s41593-022-01103-8},
   Key = {fds363459}
}

@article{fds353329,
   Author = {Rodriguez-Romaguera, J and Ung, RL and Nomura, H and Otis, JM and Basiri, ML and Namboodiri, VMK and Zhu, X and Robinson, JE and van den
             Munkhof, HE and McHenry, JA and Eckman, LEH and Kosyk, O and Jhou, TC and Kash, TL and Bruchas, MR and Stuber, GD},
   Title = {Prepronociceptin-Expressing Neurons in the Extended Amygdala
             Encode and Promote Rapid Arousal Responses to Motivationally
             Salient Stimuli.},
   Journal = {Cell reports},
   Volume = {33},
   Number = {6},
   Pages = {108362},
   Year = {2020},
   Month = {November},
   url = {http://dx.doi.org/10.1016/j.celrep.2020.108362},
   Abstract = {Motivational states consist of cognitive, emotional, and
             physiological components controlled by multiple brain
             regions. An integral component of this neural circuitry is
             the bed nucleus of the stria terminalis (BNST). Here, we
             identify that neurons within BNST that express the gene
             prepronociceptin (Pnoc<sup>BNST</sup>) modulate rapid
             changes in physiological arousal that occur upon exposure to
             motivationally salient stimuli. Using in vivo two-photon
             calcium imaging, we find that Pnoc<sup>BNST</sup> neuronal
             responses directly correspond with rapid increases in
             pupillary size when mice are exposed to aversive and
             rewarding odors. Furthermore, optogenetic activation of
             these neurons increases pupillary size and anxiety-like
             behaviors but does not induce approach, avoidance, or
             locomotion. These findings suggest that excitatory responses
             in Pnoc<sup>BNST</sup> neurons encode rapid arousal
             responses that modulate anxiety states. Further
             histological, electrophysiological, and single-cell RNA
             sequencing data reveal that Pnoc<sup>BNST</sup> neurons are
             composed of genetically and anatomically identifiable
             subpopulations that may differentially tune rapid arousal
             responses to motivational stimuli.},
   Doi = {10.1016/j.celrep.2020.108362},
   Key = {fds353329}
}

@article{fds348421,
   Author = {Torruella-Suárez, ML and Vandenberg, JR and Cogan, ES and Tipton,
             GJ and Teklezghi, A and Dange, K and Patel, GK and McHenry, JA and Hardaway, JA and Kantak, PA and Crowley, NA and DiBerto, JF and Faccidomo, SP and Hodge, CW and Stuber, GD and McElligott,
             ZA},
   Title = {Manipulations of Central Amygdala Neurotensin Neurons Alter
             the Consumption of Ethanol and Sweet Fluids in
             Mice.},
   Journal = {The Journal of neuroscience : the official journal of the
             Society for Neuroscience},
   Volume = {40},
   Number = {3},
   Pages = {632-647},
   Year = {2020},
   Month = {January},
   url = {http://dx.doi.org/10.1523/jneurosci.1466-19.2019},
   Abstract = {The central nucleus of the amygdala plays a significant role
             in alcohol use and other affective disorders; however, the
             genetically-defined neuronal subtypes and projections that
             govern these behaviors are not well known. Here we show that
             neurotensin neurons in the central nucleus of the amygdala
             of male mice are activated by <i>in vivo</i> ethanol
             consumption and that genetic ablation of these neurons
             decreases ethanol consumption and preference in
             non-ethanol-dependent animals. This ablation did not impact
             preference for sucrose, saccharin, or quinine. We found that
             the most robust projection of the central amygdala
             neurotensin neurons was to the parabrachial nucleus, a brain
             region known to be important in feeding behaviors,
             conditioned taste aversion, and alarm. Optogenetic
             stimulation of projections from these neurons to the
             parabrachial nucleus is reinforcing, and increases ethanol
             drinking as well as consumption of sucrose and saccharin
             solutions. These data suggest that this central amygdala to
             parabrachial nucleus projection influences the expression of
             reward-related phenotypes and is a novel circuit promoting
             consumption of ethanol and palatable fluids.<b>SIGNIFICANCE
             STATEMENT</b> Alcohol use disorder (AUD) is a major health
             burden worldwide. Although ethanol consumption is required
             for the development of AUD, much remains unknown regarding
             the underlying neural circuits that govern initial ethanol
             intake. Here we show that ablation of a population of
             neurotensin-expressing neurons in the central amygdala
             decreases intake of and preference for ethanol in
             non-dependent animals, whereas the projection of these
             neurons to the parabrachial nucleus promotes consumption of
             ethanol as well as other palatable fluids.},
   Doi = {10.1523/jneurosci.1466-19.2019},
   Key = {fds348421}
}

@article{fds344835,
   Author = {Rossi, MA and Basiri, ML and McHenry, JA and Kosyk, O and Otis, JM and van
             den Munkhof, HE and Bryois, J and Hübel, C and Breen, G and Guo, W and Bulik, CM and Sullivan, PF and Stuber, GD},
   Title = {Obesity remodels activity and transcriptional state of a
             lateral hypothalamic brake on feeding.},
   Journal = {Science (New York, N.Y.)},
   Volume = {364},
   Number = {6447},
   Pages = {1271-1274},
   Year = {2019},
   Month = {June},
   url = {http://dx.doi.org/10.1126/science.aax1184},
   Abstract = {The current obesity epidemic is a major worldwide health
             concern. Despite the consensus that the brain regulates
             energy homeostasis, the neural adaptations governing obesity
             are unknown. Using a combination of high-throughput
             single-cell RNA sequencing and longitudinal in vivo
             two-photon calcium imaging, we surveyed functional
             alterations of the lateral hypothalamic area (LHA)-a highly
             conserved brain region that orchestrates feeding-in a mouse
             model of obesity. The transcriptional profile of LHA
             glutamatergic neurons was affected by obesity, exhibiting
             changes indicative of altered neuronal activity. Encoding
             properties of individual LHA glutamatergic neurons were then
             tracked throughout obesity, revealing greatly attenuated
             reward responses. These data demonstrate how diet disrupts
             the function of an endogenous feeding suppression system to
             promote overeating and obesity.},
   Doi = {10.1126/science.aax1184},
   Key = {fds344835}
}

@article{fds342102,
   Author = {Robison, CL and McHenry, JA and Hull, EM},
   Title = {Increased expression of carbon monoxide-producing enzymes in
             the MPOA after sexual experience in male
             rats.},
   Journal = {Physiology & behavior},
   Volume = {171},
   Pages = {149-157},
   Year = {2017},
   Month = {March},
   url = {http://dx.doi.org/10.1016/j.physbeh.2017.01.016},
   Abstract = {The hypothalamus contains numerous nuclei involved in the
             regulation of reproductive, stress, circadian, and
             homeostatic behaviors, with many of these nuclei
             concentrated within the preoptic and anterior regions. The
             gaseous neurotransmitter, nitric oxide (NO), has already
             been shown to have an important regulatory role within the
             medial preoptic area (MPOA) of the anterior hypothalamus,
             where it facilitates sexual behaviors. However, little is
             known about the role of other gaseous neurotransmitters in
             this area. Here, we report that the carbon monoxide (CO)
             producing enzymes HO-1 and HO-2 are present in the MPOA and
             are differentially influenced by sexual experience in a
             manner similar to that previously reported for NO enzymes.
             Immunohistochemical staining of brains collected after 0, 1,
             or 7 sexual experiences reveals that HO-1 is expressed
             transiently after the first sexual experience, while HO-2
             increases only with repeated experience. This increase
             appears to be specific to the MPOA, as nearby brain areas do
             not exhibit this degree or pattern of expression. We
             observed a transient increase in HO-2 colocalization with
             neuronal nitric oxide synthase (nNOS) after a single sexual
             experience, but these cells appear to be otherwise
             disparate, despite the fact that both express within the
             central nucleus of the MPOA. Together, these findings
             suggest that endogenous CO may be behaviorally relevant
             within the MPOA and that CO and NO may be differentially
             regulated there.},
   Doi = {10.1016/j.physbeh.2017.01.016},
   Key = {fds342102}
}

@article{fds342103,
   Author = {McHenry, JA and Otis, JM and Rossi, MA and Robinson, JE and Kosyk, O and Miller, NW and McElligott, ZA and Budygin, EA and Rubinow, DR and Stuber, GD},
   Title = {Hormonal gain control of a medial preoptic area social
             reward circuit.},
   Journal = {Nature neuroscience},
   Volume = {20},
   Number = {3},
   Pages = {449-458},
   Year = {2017},
   Month = {March},
   url = {http://dx.doi.org/10.1038/nn.4487},
   Abstract = {Neural networks that control reproduction must integrate
             social and hormonal signals, tune motivation, and coordinate
             social interactions. However, the neural circuit mechanisms
             for these processes remain unresolved. The medial preoptic
             area (mPOA), an essential node for social behaviors,
             comprises molecularly diverse neurons with widespread
             projections. Here we identify a steroid-responsive subset of
             neurotensin (Nts)-expressing mPOA neurons that interface
             with the ventral tegmental area (VTA) to form a socially
             engaged reward circuit. Using in vivo two-photon imaging in
             female mice, we show that mPOA<sup>Nts</sup> neurons
             preferentially encode attractive male cues compared to
             nonsocial appetitive stimuli. Ovarian hormone signals
             regulate both the physiological and cue-encoding properties
             of these cells. Furthermore, optogenetic stimulation of
             mPOA<sup>Nts</sup>-VTA circuitry promotes rewarding
             phenotypes, social approach and striatal dopamine release.
             Collectively, these data demonstrate that steroid-sensitive
             mPOA neurons encode ethologically relevant stimuli and
             co-opt midbrain reward circuits to promote prosocial
             behaviors critical for species survival.},
   Doi = {10.1038/nn.4487},
   Key = {fds342103}
}

@article{fds342104,
   Author = {Otis, JM and Namboodiri, VMK and Matan, AM and Voets, ES and Mohorn, EP and Kosyk, O and McHenry, JA and Robinson, JE and Resendez, SL and Rossi,
             MA and Stuber, GD},
   Title = {Prefrontal cortex output circuits guide reward seeking
             through divergent cue encoding.},
   Journal = {Nature},
   Volume = {543},
   Number = {7643},
   Pages = {103-107},
   Year = {2017},
   Month = {March},
   url = {http://dx.doi.org/10.1038/nature21376},
   Abstract = {The prefrontal cortex is a critical neuroanatomical hub for
             controlling motivated behaviours across mammalian species.
             In addition to intra-cortical connectivity, prefrontal
             projection neurons innervate subcortical structures that
             contribute to reward-seeking behaviours, such as the ventral
             striatum and midline thalamus. While connectivity among
             these structures contributes to appetitive behaviours, how
             projection-specific prefrontal neurons encode
             reward-relevant information to guide reward seeking is
             unknown. Here we use in vivo two-photon calcium imaging to
             monitor the activity of dorsomedial prefrontal neurons in
             mice during an appetitive Pavlovian conditioning task. At
             the population level, these neurons display diverse activity
             patterns during the presentation of reward-predictive cues.
             However, recordings from prefrontal neurons with resolved
             projection targets reveal that individual corticostriatal
             neurons show response tuning to reward-predictive cues, such
             that excitatory cue responses are amplified across learning.
             By contrast, corticothalamic neurons gradually develop new,
             primarily inhibitory responses to reward-predictive cues
             across learning. Furthermore, bidirectional optogenetic
             manipulation of these neurons reveals that stimulation of
             corticostriatal neurons promotes conditioned reward-seeking
             behaviour after learning, while activity in corticothalamic
             neurons suppresses both the acquisition and expression of
             conditioned reward seeking. These data show how prefrontal
             circuitry can dynamically control reward-seeking behaviour
             through the opposing activities of projection-specific cell
             populations.},
   Doi = {10.1038/nature21376},
   Key = {fds342104}
}

@article{fds342105,
   Author = {Decot, HK and Namboodiri, VMK and Gao, W and McHenry, JA and Jennings,
             JH and Lee, S-H and Kantak, PA and Jill Kao and Y-C and Das, M and Witten, IB and Deisseroth, K and Shih, Y-YI and Stuber, GD},
   Title = {Coordination of Brain-Wide Activity Dynamics by Dopaminergic
             Neurons.},
   Journal = {Neuropsychopharmacology : official publication of the
             American College of Neuropsychopharmacology},
   Volume = {42},
   Number = {3},
   Pages = {615-627},
   Year = {2017},
   Month = {February},
   url = {http://dx.doi.org/10.1038/npp.2016.151},
   Abstract = {Several neuropsychiatric conditions, such as addiction and
             schizophrenia, may arise in part from dysregulated activity
             of ventral tegmental area dopaminergic (TH<sup>VTA</sup>)
             neurons, as well as from more global maladaptation in
             neurocircuit function. However, whether TH<sup>VTA</sup>
             activity affects large-scale brain-wide function remains
             unknown. Here we selectively activated TH<sup>VTA</sup>
             neurons in transgenic rats and measured resulting changes in
             whole-brain activity using stimulus-evoked functional
             magnetic resonance imaging. Applying a standard generalized
             linear model analysis approach, our results indicate that
             selective optogenetic stimulation of TH<sup>VTA</sup>
             neurons enhanced cerebral blood volume signals in striatal
             target regions in a dopamine receptor-dependent manner.
             However, brain-wide voxel-based principal component analysis
             of the same data set revealed that dopaminergic modulation
             activates several additional anatomically distinct regions
             throughout the brain, not typically associated with dopamine
             release events. Furthermore, explicit pairing of
             TH<sup>VTA</sup> neuronal activation with a forepaw stimulus
             of a particular frequency expanded the sensory
             representation of that stimulus, not exclusively within the
             somatosensory cortices, but brain-wide. These data suggest
             that modulation of TH<sup>VTA</sup> neurons can impact brain
             dynamics across many distributed anatomically distinct
             regions, even those that receive little to no direct
             TH<sup>VTA</sup> input.},
   Doi = {10.1038/npp.2016.151},
   Key = {fds342105}
}

@article{fds342106,
   Author = {McHenry, JA and Robison, CL and Bell, GA and Vialou, VV and Bolaños-Guzmán, CA and Nestler, EJ and Hull,
             EM},
   Title = {The role of ΔfosB in the medial preoptic area: Differential
             effects of mating and cocaine history.},
   Journal = {Behavioral neuroscience},
   Volume = {130},
   Number = {5},
   Pages = {469-478},
   Year = {2016},
   Month = {October},
   url = {http://dx.doi.org/10.1037/bne0000160},
   Abstract = {The transcription factor deltaFosB (ΔFosB) is induced in
             the nucleus accumbens (NAc) by repeated exposure to drugs of
             abuse and natural rewards. Less is known about its role in
             other brain areas. Here, we compared the effects of mating
             versus cocaine history on induction of ΔFosB in the medial
             preoptic area (MPOA), an integral site for reproductive
             behavior, and in the NAc. ΔFosB immunoreactivity (ir) was
             increased in the MPOA of previously naïve and experienced
             male rats that mated the day before euthanasia, compared to
             unmated controls and experienced males with recent mating
             abstinence. Western immunoblots confirmed that the 35-37-kDa
             isoform of ΔFosB was increased more in recently mated
             males. Conversely, previous plus recent cocaine did not
             increase ΔFosB-ir in the MPOA, despite an increase in the
             NAc. Next, a viral vector expressing ΔFosB, its dominant
             negative antagonist ΔJunD, or green fluorescent protein
             (GFP) control, were microinjected bilaterally into the MPOA.
             ΔFosB overexpression impaired copulation and promoted
             female-directed aggression, compared to ΔJunD and control
             males. These data suggest that ΔFosB in the mPOA is
             expressed in an experience-dependent manner and affects
             systems that coordinate mating and aggression. (PsycINFO
             Database Record},
   Doi = {10.1037/bne0000160},
   Key = {fds342106}
}

@article{fds342107,
   Author = {Resendez, SL and Jennings, JH and Ung, RL and Namboodiri, VMK and Zhou,
             ZC and Otis, JM and Nomura, H and McHenry, JA and Kosyk, O and Stuber,
             GD},
   Title = {Visualization of cortical, subcortical and deep brain neural
             circuit dynamics during naturalistic mammalian behavior with
             head-mounted microscopes and chronically implanted
             lenses.},
   Journal = {Nature protocols},
   Volume = {11},
   Number = {3},
   Pages = {566-597},
   Year = {2016},
   Month = {March},
   url = {http://dx.doi.org/10.1038/nprot.2016.021},
   Abstract = {Genetically encoded calcium indicators for visualizing
             dynamic cellular activity have greatly expanded our
             understanding of the brain. However, owing to the
             light-scattering properties of the brain, as well as the
             size and rigidity of traditional imaging technology, in vivo
             calcium imaging has been limited to superficial brain
             structures during head-fixed behavioral tasks. These
             limitations can now be circumvented by using miniature,
             integrated microscopes in conjunction with an implantable
             microendoscopic lens to guide light into and out of the
             brain, thus permitting optical access to deep brain (or
             superficial) neural ensembles during naturalistic behaviors.
             Here we describe steps to conduct such imaging studies using
             mice. However, we anticipate that the protocol can be easily
             adapted for use in other small vertebrates. Successful
             completion of this protocol will permit cellular imaging of
             neuronal activity and the generation of data sets with
             sufficient statistical power to correlate neural activity
             with stimulus presentation, physiological state and other
             aspects of complex behavioral tasks. This protocol takes
             6-11 weeks to complete.},
   Doi = {10.1038/nprot.2016.021},
   Key = {fds342107}
}

@article{fds342108,
   Author = {Cone, JJ and Fortin, SM and McHenry, JA and Stuber, GD and McCutcheon,
             JE and Roitman, MF},
   Title = {Physiological state gates acquisition and expression of
             mesolimbic reward prediction signals.},
   Journal = {Proceedings of the National Academy of Sciences of the
             United States of America},
   Volume = {113},
   Number = {7},
   Pages = {1943-1948},
   Year = {2016},
   Month = {February},
   url = {http://dx.doi.org/10.1073/pnas.1519643113},
   Abstract = {Phasic dopamine signaling participates in associative
             learning by reinforcing associations between outcomes
             (unconditioned stimulus; US) and their predictors
             (conditioned stimulus; CS). However, prior work has always
             engendered these associations with innately rewarding
             stimuli. Thus, whether dopamine neurons can acquire
             prediction signals in the absence of appetitive experience
             and update them when the value of the outcome changes
             remains unknown. Here, we used sodium depletion to
             reversibly manipulate the appetitive value of a hypertonic
             sodium solution while measuring phasic dopamine signaling in
             rat nucleus accumbens. Dopamine responses to the NaCl US
             following sodium depletion updated independent of prior
             experience. In contrast, prediction signals were only
             acquired through extensive experience with a US that had
             positive affective value. Once learned, dopamine prediction
             signals were flexibly expressed in a state-dependent manner.
             Our results reveal striking differences with respect to how
             physiological state shapes dopamine signals evoked by
             outcomes and their predictors.},
   Doi = {10.1073/pnas.1519643113},
   Key = {fds342108}
}

@article{fds342109,
   Author = {McHenry, JA and Rubinow, DR and Stuber, GD},
   Title = {Maternally responsive neurons in the bed nucleus of the
             stria terminalis and medial preoptic area: Putative circuits
             for regulating anxiety and reward.},
   Journal = {Frontiers in neuroendocrinology},
   Volume = {38},
   Pages = {65-72},
   Year = {2015},
   Month = {July},
   url = {http://dx.doi.org/10.1016/j.yfrne.2015.04.001},
   Abstract = {Postpartum neuropsychiatric disorders are a major source of
             morbidity and mortality and affect at least 10% of
             childbearing women. Affective dysregulation within this
             context has been identified in association with changes in
             reproductive steroids. Steroids promote maternal actions and
             modulate affect, but can also destabilize mood in some but
             not all women. Potential brain regions that mediate these
             effects include the medial preoptic area (mPOA) and ventral
             bed nucleus of the stria terminalis (vBNST). Herein, we
             review the regulation of neural activity in the mPOA/vBNST
             by environmental and hormonal concomitants in puerperal
             females. Such activity may influence maternal anxiety and
             motivation and have significant implications for postpartum
             affective disorders. Future directions for research are also
             explored, including physiological circuit-level approaches
             to gain insight into the functional connectivity of
             hormone-responsive maternal circuits that modulate
             affect.},
   Doi = {10.1016/j.yfrne.2015.04.001},
   Key = {fds342109}
}

@article{fds342110,
   Author = {McHenry, J and Carrier, N and Hull, E and Kabbaj,
             M},
   Title = {Sex differences in anxiety and depression: role of
             testosterone.},
   Journal = {Frontiers in neuroendocrinology},
   Volume = {35},
   Number = {1},
   Pages = {42-57},
   Year = {2014},
   Month = {January},
   url = {http://dx.doi.org/10.1016/j.yfrne.2013.09.001},
   Abstract = {Compelling evidence exists for pervasive sex differences in
             pathological conditions, including anxiety and depressive
             disorders, with females more than twice as likely to be
             afflicted. Gonadal hormones may be a major factor in this
             disparity, given that women are more likely to experience
             mood disturbances during times of hormonal flux, and
             testosterone may have protective benefits against anxiety
             and depression. In this review we focus on the effects of
             testosterone in males and females, revealed in both human
             and animal studies. We also present possible neurobiological
             mechanisms underlying testosterone's mostly protective
             benefits, including the brain regions, neural circuits, and
             cellular and molecular pathways involved. While the precise
             underlying mechanisms remain unclear, both activational and
             organizational effects of testosterone appear to contribute
             to these effects. Future clinical studies are necessary in
             order to better understand when and how testosterone therapy
             may be effective in both sexes.},
   Doi = {10.1016/j.yfrne.2013.09.001},
   Key = {fds342110}
}

@article{fds342112,
   Author = {McHenry, JA and Bell, GA and Parrish, BP and Hull,
             EM},
   Title = {Dopamine D1 receptors and phosphorylation of dopamine- and
             cyclic AMP-regulated phosphoprotein-32 in the medial
             preoptic area are involved in experience-induced enhancement
             of male sexual behavior in rats.},
   Journal = {Behavioral neuroscience},
   Volume = {126},
   Number = {4},
   Pages = {523-529},
   Year = {2012},
   Month = {August},
   url = {http://dx.doi.org/10.1037/a0028707},
   Abstract = {The medial preoptic area (MPOA) is an integral site for male
             sexual behavior. Dopamine is released in the MPOA before and
             during copulation and facilitates male rat sexual behavior.
             Repeated sexual experience and noncopulatory exposures to an
             estrous female facilitate subsequent copulation. However,
             the neurobiological mechanisms that mediate such enhancement
             remain unclear. Here, we examined the role of dopamine D₁
             receptors in the MPOA in experience-induced enhancement of
             male sexual behavior in rats. In experiment 1,
             microinjections of the D₁ antagonist SCH-23390 into the
             MPOA before each of seven daily 30-min noncopulatory
             exposures to a receptive female impaired copulation on a
             drug-free test on Day 8, compared to vehicle-treated
             female-exposed animals. Copulatory performance in
             drug-treated animals was similar to that of vehicle-treated
             males that had not been preexposed to females. This effect
             was site specific. There were no group differences in
             locomotor activity in an open field on the copulation test
             day. In experiment 2, a separate cohort of animals was used
             to examine phosphorylation of dopamine- and cAMP-regulated
             phosphoprotein (DARPP-32) in the MPOA of animals with acute
             and/or chronic sexual experience. DARPP-32 is a downstream
             marker of D₁ receptor signaling and substrate of
             cAMP-dependent protein kinase (PKA). Western immunoblot
             analysis revealed that p-DARPP-32 expression was greatest in
             the MPOA of males that received both acute and chronic
             sexual experience, compared to all other mated conditions
             and naïve controls. These data suggest that D₁ receptors
             in the MPOA contribute to experience-induced enhancement of
             male sexual behavior, perhaps through a PKA regulated
             mechanism.},
   Doi = {10.1037/a0028707},
   Key = {fds342112}
}

@article{fds342113,
   Author = {Vigdorchik, AV and Parrish, BP and Lagoda, GA and McHenry, JA and Hull,
             EM},
   Title = {An NMDA antagonist in the MPOA impairs copulation and
             stimulus sensitization in male rats.},
   Journal = {Behavioral neuroscience},
   Volume = {126},
   Number = {1},
   Pages = {186-195},
   Year = {2012},
   Month = {February},
   url = {http://dx.doi.org/10.1037/a0026460},
   Abstract = {Systemic injections of an NMDA antagonist have been shown to
             impair mating in male rats. One site where glutamate and its
             NMDA receptors may contribute to mating is the medial
             preoptic area (MPOA), which is vital for male sexual
             behavior. Glutamate is released in the MPOA during
             copulation, and especially at the time of ejaculation. We
             report here that the NMDA antagonist MK-801, microinjected
             into the MPOA, impaired copulatory behavior in sexually
             naïve as well as experienced males. In rats tested both as
             naïve and after sexual experience, drug treatment produced
             more profound impairment in naïve males. In addition,
             MK-801, microinjected into the MPOA before each of 7
             noncopulatory exposures to receptive female rats, resulted
             in copulatory impairments on a drug-free test on Day 8,
             relative to aCSF-treated rats; their behavior was similar to
             that of males that had not been preexposed to females.
             Therefore, NMDA receptors in the MPOA contribute to the
             control of copulation and stimulus sensitization. Glutamate,
             acting via NMDA receptors, regulates many neural functions,
             including neuronal plasticity. This is the first
             demonstration that a similar mechanism in the MPOA
             sensitizes male rats to the stimuli from a receptive female,
             and thereby enhances their behavior.},
   Doi = {10.1037/a0026460},
   Key = {fds342113}
}