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| Publications of Melanie J. Bonner :chronological alphabetical combined listing:
%% Journal Articles
@article{fds371817,
Author = {Meyer, R and Wang, K and Yearley, A and Grob, S and Zeitlin, J and Bloomfeld, J and You, M and Lee, D and Bonner, M and Shah, N and Page,
K},
Title = {Usability and Acceptability of the QuestLeukemia Mobile
Application: A Pilot Study for An Educational and
Psychological Intervention for Children with Chronic
Illnesses.},
Journal = {J Pediatr Hematol Oncol Nurs},
Volume = {39},
Number = {3},
Pages = {137-142},
Year = {2022},
url = {http://dx.doi.org/10.1177/27527530221068422},
Abstract = {It is widely accepted that educational interventions benefit
children with chronic diseases (disease awareness and
autonomy) or those undergoing medical procedures (decreased
anxiety and improved satisfaction). Hematopoietic cell
transplantation (HCT) is an intensive procedure to treat
life-threatening diseases but is associated with multiple
adverse medical experiences. QuestLeukemia (QuestED, Durham,
NC) is a mobile app designed to educate pediatric patients
preparing for HCT through age-appropriate videos and
quizzes. Here we describe the results of the initial pilot
study assessing acceptability and feasibility of
QuestLeukemia app. Eligible participants were selected from
a convenience sample (inpatient HCT unit and outpatient
clinic). Participants spent 30-60 min using the app then
completed a survey assessing the app for usability,
accessibility, and user satisfaction. Participants
identified the app as a useful tool for gaining
disease-related knowledge and reported greater autonomy over
their disease process. On average, patients indicated that
the app was easy to use (M = 4.93), enjoyable (M = 4.79),
and comprehensive (M = 4.71). Parents followed similar
trends of satisfaction with the app. Pediatric HCT providers
likewise reported that the app was easy to use (M = 4.22),
enjoyable (M = 4.85), and educationally comprehensive (M =
4.77). The QuestLeukemia mobile application prototype
provides an easy, enjoyable, and educational tool for
pediatric patients undergoing HCT. This application was well
received by patients, parents, and providers. These findings
will be used to design future iterations of the game in
clinical care.},
Doi = {10.1177/27527530221068422},
Key = {fds371817}
}
@article{fds358052,
Author = {Moya-Mendez, ME and Mueller, DM and Pratt, M and Bonner, M and Elliott,
C and Hunanyan, A and Kucera, G and Bock, C and Prange, L and Jasien, J and Keough, K and Shashi, V and McDonald, M and Mikati,
MA},
Title = {Early onset severe ATP1A2 epileptic encephalopathy: Clinical
characteristics and underlying mutations.},
Journal = {Epilepsy Behav},
Volume = {116},
Pages = {107732},
Year = {2021},
Month = {March},
url = {http://dx.doi.org/10.1016/j.yebeh.2020.107732},
Abstract = {BACKGROUND: ATP1A2 mutations cause hemiplegic migraine with
or without epilepsy or acute reversible encephalopathy.
Typical onset is in adulthood or older childhood without
subsequent severe long-term developmental impairments. AIM:
We aimed to describe the manifestations of early onset
severe ATP1A2-related epileptic encephalopathy and its
underlying mutations in a cohort of seven patients. METHODS:
A retrospective chart review of a cohort of seven patients
was conducted. Response to open-label memantine therapy,
used off-label due to its NMDA receptor antagonist effects,
was assessed by the Global Rating Scale of Change (GRSC) and
Clinical Global Impression Scale of Improvement (CGI-I)
methodologies. Molecular modeling was performed using PyMol
program. RESULTS: Patients (age 2.5-20 years) had symptom
onset at an early age (6 days-1 year). Seizures were
either focal or generalized. Common features were: drug
resistance, recurrent status epilepticus, etc., severe
developmental delay with episodes of acute severe
encephalopathy often with headaches, dystonias, hemiplegias,
seizures, and developmental regression. All had variants
predicted to be disease causing (p.Ile293Met, p.Glu1000Lys,
c.1017+5G>A, p.Leu809Arg, and 3 patients with p.Met813Lys).
Modeling revealed that mutations interfered with ATP1A2 ion
binding and translocation sites. Memantine, given to five,
was tolerated in all (mean treatment: 2.3 years, range
6 weeks-4.8 years) with some improvements reported in
all five. CONCLUSIONS: Our observations describe a
distinctive clinical profile of seven unrelated probands
with early onset severe ATP1A2-related epileptic
encephalopathy, provide insights into structure-function
relationships of ATP1A2 mutations, and support further
studies of NMDAR antagonist therapy in ATP1A2-encephalopathy.},
Doi = {10.1016/j.yebeh.2020.107732},
Key = {fds358052}
}
@article{fds352041,
Author = {Wallace, K and Uchitel, J and Prange, L and Jasien, J and Bonner, M and D'Alli, R and Maslow, G and Mikati, MA},
Title = {Characterization of Severe and Extreme Behavioral Problems
in Patients With Alternating Hemiplegia of
Childhood.},
Journal = {Pediatr Neurol},
Volume = {111},
Pages = {5-12},
Year = {2020},
Month = {October},
url = {http://dx.doi.org/10.1016/j.pediatrneurol.2020.06.012},
Abstract = {BACKGROUND: Alternating hemiplegia of childhood often
manifests severe or extreme behavioral problems, the nature
of which remains to be fully characterized. METHODS: We
analyzed 39 consecutive patients with alternating hemiplegia
of childhood for occurrence of behavioral problems and
categorized those by severity: mild (not requiring
intervention), moderate (requiring intervention but no
risk), severe (minor risk to self, others, or both), and
extreme (major risk). We then analyzed behavioral
manifestations, concurrent morbidity, and medication
responses in patients with severe or extreme symptoms.
RESULTS: Two patients had mild behavioral problems, five
moderate, 10 severe, six extreme, and 16 none. Extreme cases
exhibited disruptive behaviors escalating to assaults.
Triggers, when present, included peer-provocation, low
frustration tolerance, limits set by others, and sleep
disruption. Reversible psychotic symptoms occurred in two
patients: in one triggered by infection and trihexyphenidyl,
and in another triggered by sertraline. Of the 16 patients
with severe or extreme symptoms, 13 had concurrent
neuropsychiatric diagnoses. Occurrence of severe or extreme
symptoms did not correlate with age, puberty, severity of
intellectual disability, or mutation status (P > 0.05). A
multidisciplinary team including mental health professionals
comanaged all patients with severe or extreme symptoms with
either behavioral therapy, medications, or both. When
considering medications prescribed to more than four
patients, medicines that demonstrated efficacy or partial
efficacy in more than 50% of patients were alpha-adrenergic
agonists and selective-serotonin-reuptake-inhibitors.
CONCLUSIONS: Patients with alternating hemiplegia of
childhood (41%) often experience severe or extreme
behavioral problems and, rarely, medication-triggered
psychotic symptoms. These observations are consistent with
current understanding of underlying alternating hemiplegia
of childhood brain pathophysiology. Increasing awareness of
these behavioral problems facilitates alternating hemiplegia
of childhood management and anticipatory
guidance.},
Doi = {10.1016/j.pediatrneurol.2020.06.012},
Key = {fds352041}
}
@article{fds348709,
Author = {Uchitel, J and Abdelnour, E and Boggs, A and Prange, L and Pratt, M and Bonner, M and Jasien, J and Dawson, G and Abrahamsen, T and Mikati,
MA},
Title = {Social impairments in alternating hemiplegia of
childhood.},
Journal = {Dev Med Child Neurol},
Volume = {62},
Number = {7},
Pages = {820-826},
Year = {2020},
Month = {July},
url = {http://dx.doi.org/10.1111/dmcn.14473},
Abstract = {AIM: To evaluate presence and severity of social impairments
in alternating hemiplegia of childhood (AHC) and determine
factors that are associated with social impairments. METHOD:
This was a retrospective analysis of 34 consecutive patients
with AHC (19 females, 15 males; mean age: 9y 7mo, SD 8y 2mo,
range 2y 7mo-40y), evaluated with the Social Responsiveness
Scale, Second Edition (SRS-2). RESULTS: SRS-2 scores,
indicating level of social impairment, were higher than
population means (75, SD 14 vs 50, SD 10, p<0.001). Of
these, 27 out of 34 had high scores: 23 severe (>76), four
moderate (66-76). All subscale domains, including social
cognition, social communication, social awareness, social
motivation, restricted interests, and repetitive behavior,
had abnormal scores compared to population means (p<0.001).
High SRS-2 scores were associated with the presence of
autism spectrum disorder (ASD) and epilepsy (p=0.01,
p=0.04), but not with other scales of AHC disease
symptomatology. All nine patients who received formal
evaluations for ASD, because they had high SRS-2 scores,
were diagnosed with ASD. INTERPRETATION: Most patients with
AHC have impaired social skills involving multiple domains.
ASD is not uncommon. High SRS-2 scores in patients with AHC
support referral to ASD evaluation. Our findings are
consistent with current understandings of the
pathophysiology of AHC and ASD, both thought to involve
GABAergic dysfunction. WHAT THIS PAPER ADDS: Most patients
with alternating hemiplegia of childhood (AHC) have impaired
social skills involving multiple domains. These impairments
are significant compared to population means. Most patients
with AHC have high Social Responsiveness Scale, Second
Edition (SRS-2) scores. Patients with AHC with high SRS-2
scores are likely to have autism spectrum
disorder.},
Doi = {10.1111/dmcn.14473},
Key = {fds348709}
}
@article{fds349714,
Author = {Kuerten, BG and Brotkin, S and Bonner, MJ and Ayuku, DO and Njuguna, F and Taylor, SM and Puffer, ES},
Title = {Psychosocial Burden of Childhood Sickle Cell Disease on
Caregivers in Kenya.},
Journal = {Journal of pediatric psychology},
Volume = {45},
Number = {5},
Pages = {561-572},
Year = {2020},
Month = {June},
url = {http://dx.doi.org/10.1093/jpepsy/jsaa021},
Abstract = {<h4>Objectives</h4>To characterize the types and magnitude
of psychosocial burden present in caregivers who have a
child with sickle cell disease (SCD) in Kenya and to
identify predictors of caregiver psychosocial burden,
including disease severity and financial
hardship.<h4>Methods</h4>Primary caregivers (N = 103) of
children aged 1-10 years diagnosed with SCD completed
surveys assessing multiple domains of caregiver quality of
life (QOL), adjustment to child illness, mental health, and
financial hardship. Descriptive statistics characterize
psychosocial burden, and linear models assess
associations.<h4>Results</h4>On indicators of QOL,
caregivers report multiple difficulties across most domains,
including daily activities and physical, social, cognitive,
and emotional well-being. Daily activities emerged as most
burdensome. On indicators of parental adjustment to chronic
illness, guilt and worry emerged as the greatest concern,
followed by long-term uncertainty and unresolved sorrow and
anger; relative to these, they reported higher levels of
emotional resources. Financial hardship was high, as
caregivers reported moderate to major financial losses due
to the time spent caring for their child. General linear
model analyses revealed that level of financial hardship was
a significant predictor of all negative psychosocial
outcomes.<h4>Conclusions</h4>Results document that Kenyan
caregivers of children with SCD experience difficulties
across multiple domains of functioning and that financial
difficulties are likely associated with psychosocial burden.
Results can guide intervention development for caregivers of
children with SCD in low-resource, global
contexts.},
Doi = {10.1093/jpepsy/jsaa021},
Key = {fds349714}
}
@article{fds347675,
Author = {Allen, TM and Anderson, LM and Brotkin, SM and Rothman, JA and Bonner,
MJ},
Title = {Computerized cognitive training in pediatric sickle cell
disease: A randomized controlled pilot study.},
Journal = {Clinical Practice in Pediatric Psychology},
Volume = {8},
Number = {4},
Pages = {390-401},
Year = {2020},
Month = {January},
url = {http://dx.doi.org/10.1037/cpp0000313},
Abstract = {Objective: The current study assessed the feasibility of a
computerized cognitive intervention, Cogmed, in a sample of
youth with SCD (ages 8–16 years). If deemed feasible, the
secondary aim of the study was to evaluate preliminary
efficacy. Methods: Youth with SCD were randomized to a
waitlist control or the Cogmed program. Data pertaining to
cognitive functioning, psychosocial functioning, and disease
characteristics were obtained from participants pre- and
postintervention. In addition, data regarding participant
interest, consent rate, and intervention compliance were
tracked. Results: Eighteen participants (M = 12.2 years old)
enrolled in this study. Results indicate that the majority
of prospective families approached about the intervention
(82%) expressed interest in participating in the study,
although less than 25% of interested participants enrolled.
Three of 18 consenting participants completed the
intervention. Cognitive, medical, and psychosocial factors
related to feasibility and compliance were identified.
Conclusions: Taken together, the results of this study
suggest that there is a high degree of interest for this
type of intervention but poor feasibility in practice.
Implications and future directions are discussed. (PsycInfo
Database Record (c) 2020 APA, all rights
reserved)Implications for Impact Statement: Children with
sickle cell disease (SCD) have a high risk of neurocognitive
impairment, for which there are no interventions supported
by research. While the computerized, game-like treatment
“Cogmed” has been successfully used with other groups,
the current study demonstrated very limited tolerability in
youth with SCD. Thus, additional efforts are needed to
innovate new cognitive therapies for this unique and in need
population of children. (PsycInfo Database Record (c) 2020
APA, all rights reserved)},
Doi = {10.1037/cpp0000313},
Key = {fds347675}
}
@article{fds346779,
Author = {Brotkin, SM and Maslow, GR and Bonner, MJ},
Title = {JPP Student Journal Club Commentary: The Relationship
between Parent and Child Distress in Pediatric
Cancer.},
Journal = {J Pediatr Psychol},
Volume = {44},
Number = {10},
Pages = {1137-1139},
Year = {2019},
Month = {November},
url = {http://dx.doi.org/10.1093/jpepsy/jsz080},
Doi = {10.1093/jpepsy/jsz080},
Key = {fds346779}
}
@article{fds344882,
Author = {Olivier, TW and Bass, JK and Ashford, JM and Beaulieu, R and Scott, SM and Schreiber, JE and Palmer, S and Mabbott, DJ and Swain, MA and Bonner, M and Boyle, R and Chapeiski, ML and Evankovich, KD and Armstrong, CL and Knight, SJ and Wu, S and Onar-Thomas, A and Gajjar, A and Conklin,
HM},
Title = {Cognitive Implications of Ototoxicity in Pediatric Patients
With Embryonal Brain Tumors.},
Journal = {J Clin Oncol},
Volume = {37},
Number = {18},
Pages = {1566-1575},
Year = {2019},
Month = {June},
url = {http://dx.doi.org/10.1200/JCO.18.01358},
Abstract = {PURPOSE: Sensorineural hearing loss (SNHL) is associated
with intellectual and academic declines in children treated
for embryonal brain tumors. This study expands upon existing
research by examining core neurocognitive processes that may
result in reading difficulties in children with
treatment-related ototoxicity. PATIENTS AND METHODS:
Prospectively gathered, serial, neuropsychological and
audiology data for 260 children and young adults age 3 to 21
years (mean, 9.15 years) enrolled in a multisite research
and treatment protocol, which included surgery, risk-adapted
craniospinal irradiation (average risk, n = 186; high risk,
n = 74), and chemotherapy, were analyzed using linear mixed
models. Participants were assessed at baseline and up to 5
years after diagnosis and grouped according to degree of
SNHL. Included were 196 children with intact hearing or mild
to moderate SNHL (Chang grade 0, 1a, 1b, or 2a) and 64
children with severe SNHL (Chang grade 2b or greater).
Performance on eight neurocognitive variables targeting
reading outcomes (eg, phonemics, fluency, comprehension) and
contributory cognitive processes (eg, working memory,
processing speed) was analyzed. RESULTS: Participants with
severe SNHL performed significantly worse on all variables
compared with children with normal or mild to moderate SNHL
(P ≤ .05), except for tasks assessing awareness of sounds
and working memory. Controlling for age at diagnosis and
risk-adapted craniospinal irradiation dose, performance on
the following four variables remained significantly lower
for children with severe SNHL: phonemic skills, phonetic
decoding, reading comprehension, and speed of information
processing (P ≤ .05). CONCLUSION: Children with severe
SNHL exhibit greater reading difficulties over time.
Specifically, they seem to struggle most with phonological
skills and processing speed, which affect higher level
skills such as reading comprehension.},
Doi = {10.1200/JCO.18.01358},
Key = {fds344882}
}
@article{fds343762,
Author = {Porter, LS and Baucom, DH and Bonner, M and Linardic, C and Kazak,
AE},
Title = {Parenting a child with cancer: a couple-based
approach.},
Journal = {Transl Behav Med},
Volume = {9},
Number = {3},
Pages = {504-513},
Year = {2019},
Month = {May},
url = {http://dx.doi.org/10.1093/tbm/ibz016},
Abstract = {Couples co-parenting a child with cancer face significant
stressors that can adversely affect their couple
relationship. How parents respond as a couple may affect the
psychological adjustment of each parent and the child, as
well as the ability of the family to cope with the child's
illness. The purpose of this study was to assess the
feasibility and acceptability of a couple-based intervention
for parents of children with cancer. We conducted a
randomized pilot intervention study (N = 21 couples
randomized with a 2:1 allocation to the couple-based
intervention or education control) testing a six-session,
telephone-based intervention that trained couples in
relationship skills to help them care for their child,
strengthen their relationship, and support each other. We
examined feasibility and acceptability of the intervention
to the parents. In this study, 56% of eligible couples
agreed to participate; 82% of randomized couples completed
post-intervention surveys, and 62% completed all six
sessions. Satisfaction with the intervention was high (mean
= 3.3 on a 4-point scale). Changes in both groups were small
in magnitude and mixed in direction, with some outcomes
favoring the couple-based intervention and other favoring
the education condition. Supporting couples is important to
optimize individual and parental functioning when a child
has cancer. However, there are significant challenges to
delivering couple-based interventions to these parents. More
research is needed to establish optimal timing and content
of couple-based interventions for these parents as well as
feasible methods of delivery.},
Doi = {10.1093/tbm/ibz016},
Key = {fds343762}
}
@article{fds339603,
Author = {Jasien, JM and Bonner, M and D'alli, R and Prange, L and Mclean, M and Sachdev, M and Uchitel, J and Ricano, J and Smith, B and Mikati,
MA},
Title = {Cognitive, adaptive, and behavioral profiles and management
of alternating hemiplegia of childhood.},
Journal = {Dev Med Child Neurol},
Volume = {61},
Number = {5},
Pages = {547-554},
Year = {2019},
Month = {May},
url = {http://dx.doi.org/10.1111/dmcn.14077},
Abstract = {AIM: To determine the neuropsychological abnormalities that
occur in alternating hemiplegia of childhood (AHC) and
report on our experience in managing them. METHOD: Patients
underwent evaluations according to our standardized AHC
pathway. Data were entered into our prospective AHC database
and then analyzed. RESULTS: Of the cohort of 25 consecutive
patients (ages 15mo-42y), eight had initial chief complaints
about cognition, 14 language, five attention, and 11
behavior. As compared to population norms means,
neuropsychological and behavioral assessment tools
(including Child Behavior Checklist, Vineland Adaptive
Behavior Scales, Peabody Picture Vocabulary, and Wechsler
Intelligence Quotient tests) showed significant impairments
in multiple domains: cognition, expressive and receptive
language, executive function/attention, and behavior (p<0.05
in all comparisons). Evaluations generated management
recommendations in all patients. Twenty had neuropsychiatric
diagnoses: 10 attention-deficit/hyperactivity disorder
(ADHD), seven disruptive behavior, and three anxiety
disorder. Eight out of nine patients with ADHD who were
prescribed medications responded to pharmacotherapy.
INTERPRETATION: Patients with AHC have developmental
difficulties related to impairments in multiple
neuropsychological domains. This supports the hypothesis
that the underlying AHC pathophysiology involves diffuse
neuronal dysfunction. Testing generated recommendations to
help manage these difficulties. Patients with AHC also have
a range of neuropsychiatric diagnoses, the most common being
ADHD which responds to pharmacotherapy. WHAT THIS PAPER
ADDS: Patients with alternating hemiplegia of childhood
(AHC) have developmental difficulties with underlying
neuropsychological impairments. The findings in this study
are consistent with an underlying AHC pathophysiology which
involves diffuse neuronal, probably largely GABAergic,
dysfunction. Patients with AHC have a range of
neuropsychiatric diagnoses, the most common being
attention-deficit/hyperactivity disorder.},
Doi = {10.1111/dmcn.14077},
Key = {fds339603}
}
@article{fds338616,
Author = {Tan, QK-G and Cope, H and Spillmann, RC and Stong, N and Jiang, Y-H and McDonald, MT and Rothman, JA and Butler, MW and Frush, DP and Lachman,
RS and Lee, B and Bacino, CA and Bonner, MJ and McCall, CM and Pendse, AA and Walley, N and Undiagnosed Diseases Network, and Shashi, V and Pena,
LDM},
Title = {Further evidence for the involvement of EFL1 in a
Shwachman-Diamond-like syndrome and expansion of the
phenotypic features.},
Journal = {Cold Spring Harb Mol Case Stud},
Volume = {4},
Number = {5},
Year = {2018},
Month = {October},
url = {http://dx.doi.org/10.1101/mcs.a003046},
Abstract = {Recent evidence has implicated EFL1 in a phenotype
overlapping Shwachman-Diamond syndrome (SDS), with the
functional interplay between EFL1 and the previously known
causative gene SBDS accounting for the similarity in
clinical features. Relatively little is known about the
phenotypes associated with pathogenic variants in the EFL1
gene, but the initial indication was that phenotypes may be
more severe, when compared with SDS. We report a pediatric
patient who presented with a metaphyseal dysplasia and was
found to have biallelic variants in EFL1 on reanalysis of
trio whole-exome sequencing data. The variant had not been
initially reported because of the research laboratory's
focus on de novo variants. Subsequent phenotyping revealed
variability in her manifestations. Although her metaphyseal
abnormalities were more severe than in the original reported
cohort with EFL1 variants, the bone marrow abnormalities
were generally mild, and there was equivocal evidence for
pancreatic insufficiency. Despite the limited number of
reported patients, variants in EFL1 appear to cause a
broader spectrum of symptoms that overlap with those seen in
SDS. Our report adds to the evidence of EFL1 being
associated with an SDS-like phenotype and provides
information adding to our understanding of the phenotypic
variability of this disorder. Our report also highlights the
value of exome data reanalysis when a diagnosis is not
initially apparent.},
Doi = {10.1101/mcs.a003046},
Key = {fds338616}
}
@article{fds336054,
Author = {Anderson, LM and Leonard, S and Jonassaint, J and Lunyera, J and Bonner,
M and Shah, N},
Title = {Mobile health intervention for youth with sickle cell
disease: Impact on adherence, disease knowledge, and quality
of life.},
Journal = {Pediatr Blood Cancer},
Volume = {65},
Number = {8},
Pages = {e27081},
Publisher = {WILEY},
Year = {2018},
Month = {August},
url = {http://dx.doi.org/10.1002/pbc.27081},
Abstract = {BACKGROUND: Adherence to illness self-management among youth
with sickle cell disease (SCD) positively impacts health
outcomes and decreases overall healthcare costs. Despite
this, children with SCD face several barriers to adherence,
with adherence rates that remain moderate to low. The
current feasibility study examined the Intensive Training
Program (ITP), a mobile health (mHealth) intervention for
youth with SCD designed to promote disease knowledge,
adherence, and patient-provider communication. PROCEDURE:
Youth with SCD prescribed hydroxyurea between ages 7-18
completed baseline disease knowledge and psychosocial
assessments and then were provided with the ITP app. Youth
participated in the 90-day ITP, during which they completed
three education modules, tracked adherence through daily
self-recorded videos on the app, and received video messages
from providers. Participants completed poststudy knowledge,
psychosocial, and feasibility questionnaires. Medication
possession ratio (MPR) was obtained via pharmacy-refill
rates. RESULTS: Thirty-two youths (mean age = 13.0 years)
participated, with an average adherence tracking rate of 0.6
(standard deviation = 0.34). All participants demonstrated
increased MPR (0.57-0.74, P < 0.001, d = 0.75) and
disease knowledge (59.6-88.6%, P < 0.001). There was
variable engagement in the ITP; completers demonstrated
significantly better SCD-related functioning (P < 0.05),
higher parent-reported treatment functioning (P < 0.05),
and lower pain impact than noncompleters of the ITP
(P < 0.05). CONCLUSIONS: Results support the ITP can
feasibly be implemented to promote adherence among youth
with SCD. All participants demonstrated increased adherence
and disease knowledge. However, there was variable
engagement and only intervention completers showed
improvements in psychosocial outcomes. Further research is
needed to evaluate long-term outcomes and ways to promote
engagement in mHealth interventions among the
youth.},
Doi = {10.1002/pbc.27081},
Key = {fds336054}
}
@article{fds330040,
Author = {Schreiber, JE and Palmer, SL and Conklin, HM and Mabbott, DJ and Swain,
MA and Bonner, MJ and Chapieski, ML and Huang, L and Zhang, H and Gajjar,
A},
Title = {Posterior fossa syndrome and long-term neuropsychological
outcomes among children treated for medulloblastoma on a
multi-institutional, prospective study.},
Journal = {Neuro Oncol},
Volume = {19},
Number = {12},
Pages = {1673-1682},
Year = {2017},
Month = {November},
url = {http://dx.doi.org/10.1093/neuonc/nox135},
Abstract = {BACKGROUND: Patients treated for medulloblastoma who
experience posterior fossa syndrome (PFS) demonstrate
increased risk for neurocognitive impairment at one year
post diagnosis. The aim of the study was to examine
longitudinal trajectories of neuropsychological outcomes in
patients who experienced PFS compared with patients who did
not. METHODS: Participants were 36 patients (22 males) who
experienced PFS and 36 comparison patients (21 males) who
were matched on age at diagnosis and treatment exposure but
did not experience PFS. All patients underwent serial
evaluation of neurocognitive functioning spanning 1 to 5
years post diagnosis. RESULTS: The PFS group demonstrated
lower estimated mean scores at 1, 3, and 5 years post
diagnosis on measures of general intellectual ability,
processing speed, broad attention, working memory, and
spatial relations compared with the non-PFS group. The PFS
group exhibited estimated mean scores that were at least one
standard deviation below the mean for intellectual ability,
processing speed, and broad attention across all time points
and for working memory by 5 years post diagnosis. Processing
speed was stable over time. Attention and working memory
declined over time. Despite some change over time, caregiver
ratings of executive function and behavior problem symptoms
remained within the average range. CONCLUSION: Compared with
patients who do not experience PFS, patients who experience
PFS exhibit greater neurocognitive impairment, show little
recovery over time, and decline further in some domains.
Findings highlight the particularly high risk for long-term
neurocognitive problems in patients who experience PFS and
the need for close follow-up and intervention.},
Doi = {10.1093/neuonc/nox135},
Key = {fds330040}
}
@article{fds319600,
Author = {Allen, TM and Anderson, LM and Rothman, JA and Bonner,
MJ},
Title = {[Formula: see text]Executive functioning and health-related
quality of life in pediatric sickle cell
disease.},
Journal = {Child Neuropsychol},
Volume = {23},
Number = {8},
Pages = {889-906},
Year = {2017},
Month = {November},
url = {http://dx.doi.org/10.1080/09297049.2016.1205011},
Abstract = {Research consistently indicates that children with sickle
cell disease (SCD) face multiple risk factors for
neurocognitive impairment. Despite this, no empirical
research to date has examined the impact of neurocognitive
functioning on quality of life for this pediatric group.
Thus, the current study aims to examine the relationship
between executive functioning and quality of life in a
sample of children with SCD and further explore psychosocial
and family/caregiver resources as moderators of this
relationship. A total of 45 children with SCD aged 8 to 16
years and their caregivers completed measures of quality of
life, behavioral ratings of executive functioning, and
psychosocial functioning. Hierarchical linear regression
models were utilized to determine the impact of executive
functioning on quality of life and further test the
interaction effects of proposed moderating variables.
Controlling for age, pain, and socioeconomic status (SES),
executive functioning was found to significantly predict
child- and parent-reported quality of life among youth with
SCD. Psychosocial resources of the primary caregiver or
family was not found to moderate the relationship between
executive functioning and quality of life. These results
provide the first empirical evidence that lower executive
skills negatively predict quality of life for children with
SCD, supporting clinical and research efforts which aim to
establish efficacious interventions that target cognitive
decrements within this pediatric population.},
Doi = {10.1080/09297049.2016.1205011},
Key = {fds319600}
}
@article{fds330041,
Author = {Gallentine, WB and Shinnar, S and Hesdorffer, DC and Epstein, L and Nordli, DR and Lewis, DV and Frank, LM and Seinfeld, S and Shinnar, RC and Cornett, K and Liu, B and Moshé, SL and Sun, S and FEBSTAT Investigator
Team},
Title = {Plasma cytokines associated with febrile status epilepticus
in children: A potential biomarker for acute hippocampal
injury.},
Journal = {Epilepsia},
Volume = {58},
Number = {6},
Pages = {1102-1111},
Year = {2017},
Month = {June},
url = {http://dx.doi.org/10.1111/epi.13750},
Abstract = {OBJECTIVE: Our aim was to explore the association between
plasma cytokines and febrile status epilepticus (FSE) in
children, as well as their potential as biomarkers of acute
hippocampal injury. METHODS: Analysis was performed on
residual samples of children with FSE (n = 33) as part of
the Consequences of Prolonged Febrile Seizures in Childhood
study (FEBSTAT) and compared to children with fever
(n = 17). Magnetic resonance imaging (MRI) was obtained as
part of FEBSTAT within 72 h of FSE. Cytokine levels and
ratios of antiinflammatory versus proinflammatory cytokines
in children with and without hippocampal T2 hyperintensity
were assessed as biomarkers of acute hippocampal injury
after FSE. RESULTS: Levels of interleukin (IL)-8 and
epidermal growth factor (EGF) were significantly elevated
after FSE in comparison to controls. IL-1β levels trended
higher and IL-1RA trended lower following FSE, but did not
reach statistical significance. Children with FSE were found
to have significantly lower ratios of IL-1RA/IL-1β and
IL-1RA/IL-8. Specific levels of any one individual cytokine
were not associated with FSE. However, lower ratios of
IL-1RA/IL-1β, IL-1RA/1L-6, and IL-1RA/ IL-8 were all
associated with FSE. IL-6 and IL-8 levels were significantly
higher and ratios of IL-1RA/IL-6 and IL-1RA/IL-8 were
significantly lower in children with T2 hippocampal
hyperintensity on MRI after FSE in comparison to those
without hippocampal signal abnormalities. Neither individual
cytokine levels nor ratios of IL-1RA/IL-1β or IL-1RA/IL-8
were predictive of MRI changes. However, a lower ratio of
IL-1RA/IL-6 was strongly predictive (odds ratio [OR] 21.5,
95% confidence interval [CI] 1.17-393) of hippocampal T2
hyperintensity after FSE. SIGNIFICANCE: Our data support
involvement of the IL-1 cytokine system, IL-6, and IL-8 in
FSE in children. The identification of the IL-1RA/IL-6 ratio
as a potential biomarker of acute hippocampal injury
following FSE is the most significant finding. If replicated
in another study, the IL-1RA/IL-6 ratio could represent a
serologic biomarker that offers rapid identification of
patients at risk for ultimately developing mesial temporal
lobe epilepsy (MTLE).},
Doi = {10.1111/epi.13750},
Key = {fds330041}
}
@article{fds316069,
Author = {Willard, VW and Allen, TM and Hardy, KK and Bonner,
MJ},
Title = {Social functioning in survivors of pediatric brain tumors:
Contribution of neurocognitive and social-cognitive
skills},
Journal = {Children's Health Care},
Volume = {46},
Number = {2},
Pages = {181-195},
Publisher = {Informa UK Limited},
Year = {2017},
Month = {April},
ISSN = {0273-9615},
url = {http://dx.doi.org/10.1080/02739615.2015.1124769},
Abstract = {This study assessed neurocognitive and social-cognitive
skills in survivors of pediatric brain tumors, and evaluated
their combined contribution to social outcomes. Survivors
(N = 10) and typically developing children (N = 41),
aged 8–16, completed measures of neurocognitive and
social-cognitive skills, and social functioning/adjustment.
Survivors demonstrated difficulties across domains as
compared to typically developing children. Hierarchical
regression analyses with the combined sample suggested that
the combination of neurocognitive and social-cognitive
skills accounted for over half of the variance in
parent-reported social functioning. Inattentive symptoms and
recognition of child faces were significantly associated
with social outcomes. Increasing our understanding of social
outcomes in survivors is critical to the creation of
targeted interventions.},
Doi = {10.1080/02739615.2015.1124769},
Key = {fds316069}
}
@article{fds324821,
Author = {Shashi, V and Pena, LDM and Kim, K and Burton, B and Hempel, M and Schoch,
K and Walkiewicz, M and McLaughlin, HM and Cho, M and Stong, N and Hickey,
SE and Shuss, CM and Undiagnosed Diseases Network, and Freemark, MS and Bellet, JS and Keels, MA and Bonner, MJ and El-Dairi, M and Butler, M and Kranz, PG and Stumpel, CTRM and Klinkenberg, S and Oberndorff, K and Alawi, M and Santer, R and Petrovski, S and Kuismin, O and Korpi-Heikkilä, S and Pietilainen, O and Aarno, P and Kurki, MI and Hoischen, A and Need, AC and Goldstein, DB and Kortüm,
F},
Title = {De Novo Truncating Variants in ASXL2 Are Associated with a
Unique and Recognizable Clinical Phenotype.},
Journal = {Am J Hum Genet},
Volume = {100},
Number = {1},
Pages = {179},
Year = {2017},
Month = {January},
url = {http://dx.doi.org/10.1016/j.ajhg.2016.12.004},
Doi = {10.1016/j.ajhg.2016.12.004},
Key = {fds324821}
}
@article{fds330042,
Author = {Weiss, EF and Masur, D and Shinnar, S and Hesdorffer, DC and Hinton, VJ and Bonner, M and Rinaldi, J and Van de Water and V and Culbert, J and Shinnar,
RC and Seinfeld, S and Gallentine, W and Nordli, DR and Frank, LM and Epstein, L and Moshé, SL and Sun, S and FEBSTAT study
team},
Title = {Cognitive functioning one month and one year following
febrile status epilepticus.},
Journal = {Epilepsy Behav},
Volume = {64},
Number = {Pt A},
Pages = {283-288},
Year = {2016},
Month = {November},
url = {http://dx.doi.org/10.1016/j.yebeh.2016.09.013},
Abstract = {OBJECTIVE: The objective of this study was to determine
early developmental and cognitive outcomes of children with
febrile status epilepticus (FSE) one month and one year
after FSE. METHODS: One hundred ninety four children with
FSE were evaluated on measures of cognition, receptive
language, and memory as part of the FEBSTAT study and
compared with 100 controls with simple febrile seizures
(FSs). RESULTS: Children with FSE did not differ
dramatically on tasks compared with FS controls at one month
after FSE but demonstrated slightly weaker motor development
(p=0.035) and receptive language (p=0.034) at one year after
FSE. Performances were generally within the low average to
average range. Within the FSE cohort, non-White children
performed weaker on many of the tasks compared with
Caucasian children. At the one-year visit, acute hippocampal
T2 findings on MRI were associated with weaker receptive
language skills (p=0.0009), and human herpes virus 6 or 7
(HHV6/7) viremia was associated with better memory
performances (p=0.047). CONCLUSION: Febrile status
epilepticus does not appear to be associated with
significant cognitive impairment on early developmental
measures, although there is a trend for possible receptive
language and motor delay one year after FSE. Further
follow-up, which is in progress, is necessary to track
long-term cognitive functioning.},
Doi = {10.1016/j.yebeh.2016.09.013},
Key = {fds330042}
}
@article{fds319599,
Author = {Shashi, V and Pena, LDM and Kim, K and Burton, B and Hempel, M and Schoch,
K and Walkiewicz, M and McLaughlin, HM and Cho, M and Stong, N and Hickey,
SE and Shuss, CM and Undiagnosed Diseases Network, and Freemark, MS and Bellet, JS and Keels, MA and Bonner, MJ and El-Dairi, M and Butler, M and Kranz, PG and Stumpel, CTRM and Klinkenberg, S and Oberndorff, K and Alawi, M and Santer, R and Petrovski, S and Kuismin, O and Korpi-Heikkilä, S and Pietilainen, O and Aarno, P and Kurki, MI and Hoischen, A and Need, AC and Goldstein, DB and Kortüm,
F},
Title = {De Novo Truncating Variants in ASXL2 Are Associated with a
Unique and Recognizable Clinical Phenotype.},
Journal = {Am J Hum Genet},
Volume = {99},
Number = {4},
Pages = {991-999},
Year = {2016},
Month = {October},
url = {http://dx.doi.org/10.1016/j.ajhg.2016.08.017},
Abstract = {The ASXL genes (ASXL1, ASXL2, and ASXL3) participate in body
patterning during embryogenesis and encode proteins involved
in epigenetic regulation and assembly of transcription
factors to specific genomic loci. Germline de novo
truncating variants in ASXL1 and ASXL3 have been
respectively implicated in causing Bohring-Opitz and
Bainbridge-Ropers syndromes, which result in overlapping
features of severe intellectual disability and dysmorphic
features. ASXL2 has not yet been associated with a human
Mendelian disorder. In this study, we performed whole-exome
sequencing in six unrelated probands with developmental
delay, macrocephaly, and dysmorphic features. All six had de
novo truncating variants in ASXL2. A careful review enabled
the recognition of a specific phenotype consisting of
macrocephaly, prominent eyes, arched eyebrows,
hypertelorism, a glabellar nevus flammeus, neonatal feeding
difficulties, hypotonia, and developmental disabilities.
Although overlapping features with Bohring-Opitz and
Bainbridge-Ropers syndromes exist, features that distinguish
the ASXL2-associated condition from ASXL1- and ASXL3-related
disorders are macrocephaly, absence of growth retardation,
and more variability in the degree of intellectual
disabilities. We were also able to demonstrate with mRNA
studies that these variants are likely to exert a
dominant-negative effect, given that both alleles are
expressed in blood and the mutated ASXL2 transcripts escape
nonsense-mediated decay. In conclusion, de novo truncating
variants in ASXL2 underlie a neurodevelopmental syndrome
with a clinically recognizable phenotype. This report
expands the germline disorders that are linked to the ASXL
genes.},
Doi = {10.1016/j.ajhg.2016.08.017},
Key = {fds319599}
}
@article{fds311652,
Author = {Willard, VW and Hostetter, SA and Hutchinson, KC and Bonner, MJ and Hardy, KK},
Title = {Benefit Finding in Maternal Caregivers of Pediatric Cancer
Survivors: A Mixed Methods Approach.},
Journal = {J Pediatr Oncol Nurs},
Volume = {33},
Number = {5},
Pages = {353-360},
Year = {2016},
Month = {September},
ISSN = {1043-4542},
url = {http://dx.doi.org/10.1177/1043454215620119},
Abstract = {OBJECTIVE: Benefit finding has been described as the
identification of positive effects resulting from otherwise
stressful experiences. In this mixed methods study, we
examined the relations between qualitative themes related to
benefit finding and quantitative measures of psychosocial
adjustment and coping as reported by maternal caregivers of
survivors of pediatric cancer. METHODS: Female caregivers of
survivors of pediatric cancer (n = 40) completed a
qualitative questionnaire about their experiences caring for
their child, along with several quantitative measures.
Qualitative questionnaires were coded for salient themes,
including social support and personal growth. Correlation
matrices evaluated associations between qualitative themes
and quantitative measures of stress and coping. RESULTS:
Identified benefits included social support and personal
growth, as well as child-specific benefits. Total benefits
reported were significantly positively correlated with
availability of emotional resources. Coping methods were
also associated, with accepting responsibility associated
with fewer identified benefits. CONCLUSION: Despite the
stress of their child's illness, many female caregivers of
survivors of pediatric cancer reported finding benefits
associated with their experience. Benefit finding in this
sample was associated with better adjustment.},
Doi = {10.1177/1043454215620119},
Key = {fds311652}
}
@article{fds330043,
Author = {Hesdorffer, DC and Shinnar, S and Lax, DN and Pellock, JM and Nordli,
DR and Seinfeld, S and Gallentine, W and Frank, LM and Lewis, DV and Shinnar, RC and Bello, JA and Chan, S and Epstein, LG and Moshé, SL and Liu, B and Sun, S and FEBSTAT study team},
Title = {Risk factors for subsequent febrile seizures in the FEBSTAT
study.},
Journal = {Epilepsia},
Volume = {57},
Number = {7},
Pages = {1042-1047},
Year = {2016},
Month = {July},
url = {http://dx.doi.org/10.1111/epi.13418},
Abstract = {OBJECTIVES: To identify risk and risk factors for developing
a subsequent febrile seizure (FS) in children with a first
febrile status epilepticus (FSE) compared to a first simple
febrile seizure (SFS). To identify home use of rescue
medications for subsequent FS. METHODS: Cases included a
first FS that was FSE drawn from FEBSTAT and Columbia
cohorts. Controls were a first SFS. Cases and controls were
classified according to established FEBSTAT protocols.
Cumulative risk for subsequent FS over a 5-year period was
compared in FSE versus SFS, and Cox proportional hazards
regression was conducted. Separate analysis examined
subsequent FS within FSE. The use of rescue medications at
home was assessed for subsequent FS. RESULTS: Risk for a
subsequent FSE was significantly increased in FSE versus
SFS. Any magnetic resonance imaging (MRI) abnormality
increased the risk 3.4-fold (p < 0.05), adjusting for age at
first FS and FSE and in analyses restricted to children
whose first FS was FSE (any MRI abnormality hazard ratio
[HR] 2.9, p < 0.05). The risk for a second FS of any type or
of subsequent FS lasting >10 min over the 5-year follow-up
did not differ in FSE versus SFS. Rectal diazepam was
administered at home to 5 (23.8%) of 21 children with
subsequent FS lasting ≥10 min. SIGNIFICANCE: Compared to
controls, FSE was associated with an increased risk for
subsequent FSE, suggesting the propensity of children with
an initial prolonged seizure to experience a prolonged
recurrence. Any baseline MRI abnormality increased the
recurrence risk when FSE was compared to SFS and when FSE
was studied alone. A minority of children with a subsequent
FS lasting 10 min or longer were treated with rectal
diazepam at home, despite receiving prescriptions after the
first FSE. This indicates the need to further improve the
education of clinicians and parents in order to prevent
subsequent FSE.},
Doi = {10.1111/epi.13418},
Key = {fds330043}
}
@article{fds311653,
Author = {Allen, T and Willard, VW and Anderson, LM and Hardy, KK and Bonner,
MJ},
Title = {Social functioning and facial expression recognition in
children with neurofibromatosis type 1.},
Journal = {J Intellect Disabil Res},
Volume = {60},
Number = {3},
Pages = {282-293},
Year = {2016},
Month = {March},
ISSN = {0964-2633},
url = {http://dx.doi.org/10.1111/jir.12248},
Abstract = {BACKGROUND: This study examined social functioning and
facial expression recognition (FER) in children with
neurofibromatosis type 1 (NF1) compared to typically
developing peers. Specifically, the current research aimed
to identify hypothesised relationships between
neurocognitive ability, FER and social functioning. METHOD:
Children, ages 8 to 16, with NF1 (n = 23) and typically
developing peers (n = 23) were recruited during
regularly scheduled clinic visits and through advertisements
on an institutional clinical trials website, respectively.
Participants completed a measure of FER, an abbreviated
intelligence test and questionnaires regarding their quality
of life and behavioural functioning. Parents were also asked
to complete questionnaires regarding the social-emotional
and cognitive functioning of their child. RESULTS: As
expected, there were significant differences between
children with NF1 and typically developing peers across
domains of social functioning and FER. Within the sample of
children with NF1, there were no significant associations
observed between cognitive measures, social functioning and
facial recognition skills. CONCLUSION: Children with NF1
exhibited high rates of social impairment and weak FER
skills compared to controls. The absence of associations
between FER with cognitive and social variables, however,
suggests something unique about this skill in children with
NF1. Theoretical comparisons are made to children with
autism spectrum disorders, as this condition may serve as a
potentially useful model in better understanding FER in
children with NF1.},
Doi = {10.1111/jir.12248},
Key = {fds311653}
}
@article{fds302231,
Author = {Ware, RE and Davis, BR and Schultz, WH and Brown, RC and Aygun, B and Sarnaik, S and Odame, I and Fuh, B and George, A and Owen, W and Luchtman-Jones, L and Rogers, ZR and Hilliard, L and Gauger, C and Piccone, C and Lee, MT and Kwiatkowski, JL and Jackson, S and Miller,
ST and Roberts, C and Heeney, MM and Kalfa, TA and Nelson, S and Imran, H and Nottage, K and Alvarez, O and Rhodes, M and Thompson, AA and Rothman,
JA and Helton, KJ and Roberts, D and Coleman, J and Bonner, MJ and Kutlar,
A and Patel, N and Wood, J and Piller, L and Wei, P and Luden, J and Mortier,
NA and Stuber, SE and Luban, NLC and Cohen, AR and Pressel, S and Adams,
RJ},
Title = {Hydroxycarbamide versus chronic transfusion for maintenance
of transcranial doppler flow velocities in children with
sickle cell anaemia-TCD With Transfusions Changing to
Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3,
non-inferiority trial.},
Journal = {Lancet},
Volume = {387},
Number = {10019},
Pages = {661-670},
Year = {2016},
Month = {February},
ISSN = {0140-6736},
url = {http://dx.doi.org/10.1016/S0140-6736(15)01041-7},
Abstract = {BACKGROUND: For children with sickle cell anaemia and high
transcranial doppler (TCD) flow velocities, regular blood
transfusions can effectively prevent primary stroke, but
must be continued indefinitely. The efficacy of
hydroxycarbamide (hydroxyurea) in this setting is unknown;
we performed the TWiTCH trial to compare hydroxyurea with
standard transfusions. METHODS: TWiTCH was a multicentre,
phase 3, randomised, open-label, non-inferiority trial done
at 26 paediatric hospitals and health centres in the USA and
Canada. We enrolled children with sickle cell anaemia who
were aged 4-16 years and had abnormal TCD flow velocities
(≥ 200 cm/s) but no severe vasculopathy. After screening,
eligible participants were randomly assigned 1:1 to continue
standard transfusions (standard group) or hydroxycarbamide
(alternative group). Randomisation was done at a central
site, stratified by site with a block size of four, and an
adaptive randomisation scheme was used to balance the
covariates of baseline age and TCD velocity. The study was
open-label, but TCD examinations were read centrally by
observers masked to treatment assignment and previous TCD
results. Participants assigned to standard treatment
continued to receive monthly transfusions to maintain 30%
sickle haemoglobin or lower, while those assigned to the
alternative treatment started oral hydroxycarbamide at 20
mg/kg per day, which was escalated to each participant's
maximum tolerated dose. The treatment period lasted 24
months from randomisation. The primary study endpoint was
the 24 month TCD velocity calculated from a general linear
mixed model, with the non-inferiority margin set at 15 cm/s.
The primary analysis was done in the intention-to-treat
population and safety was assessed in all patients who
received at least one dose of assigned treatment. This study
is registered with ClinicalTrials.gov, number NCT01425307.
FINDINGS: Between Sept 20, 2011, and April 17, 2013, 159
patients consented and enrolled in TWiTCH. 121 participants
passed screening and were then randomly assigned to
treatment (61 to transfusions and 60 to hydroxycarbamide).
At the first scheduled interim analysis, non-inferiority was
shown and the sponsor terminated the study. Final
model-based TCD velocities were 143 cm/s (95% CI 140-146) in
children who received standard transfusions and 138 cm/s
(135-142) in those who received hydroxycarbamide, with a
difference of 4·54 (0·10-8·98). Non-inferiority
(p=8·82 × 10(-16)) and post-hoc superiority (p=0·023)
were met. Of 29 new neurological events adjudicated
centrally by masked reviewers, no strokes were identified,
but three transient ischaemic attacks occurred in each
group. Magnetic resonance brain imaging and angiography (MRI
and MRA) at exit showed no new cerebral infarcts in either
treatment group, but worsened vasculopathy in one
participant who received standard transfusions. 23 severe
adverse events in nine (15%) patients were reported for
hydroxycarbamide and ten serious adverse events in six (10%)
patients were reported for standard transfusions. The most
common serious adverse event in both groups was
vaso-occlusive pain (11 events in five [8%] patients with
hydroxycarbamide and three events in one [2%] patient for
transfusions). INTERPRETATION: For high-risk children with
sickle cell anaemia and abnormal TCD velocities who have
received at least 1 year of transfusions, and have no
MRA-defined severe vasculopathy, hydroxycarbamide treatment
can substitute for chronic transfusions to maintain TCD
velocities and help to prevent primary stroke. FUNDING:
National Heart, Lung, and Blood Institute, National
Institutes of Health.},
Doi = {10.1016/S0140-6736(15)01041-7},
Key = {fds302231}
}
@article{fds333035,
Author = {Mikati, MA and Jiang, Y-H and Carboni, M and Shashi, V and Petrovski, S and Spillmann, R and Milligan, CJ and Li, M and Grefe, A and McConkie, A and Berkovic, S and Scheffer, I and Mullen, S and Bonner, M and Petrou, S and Goldstein, D},
Title = {Quinidine in the treatment of KCNT1-positive
epilepsies.},
Journal = {Ann Neurol},
Volume = {78},
Number = {6},
Pages = {995-999},
Year = {2015},
Month = {December},
url = {http://dx.doi.org/10.1002/ana.24520},
Abstract = {We report 2 patients with drug-resistant epilepsy caused by
KCNT1 mutations who were treated with quinidine. Both
mutations manifested gain of function in vitro, showing
increased current that was reduced by quinidine. One, who
had epilepsy of infancy with migrating focal seizures, had
80% reduction in seizure frequency as recorded in seizure
diaries, and partially validated by objective seizure
evaluation on EEG. The other, who had a novel phenotype,
with severe nocturnal focal and secondary generalized
seizures starting in early childhood with developmental
regression, did not improve. Although quinidine represents
an encouraging opportunity for therapeutic benefits, our
experience suggests caution in its application and supports
the need to identify more targeted drugs for KCNT1
epilepsies.},
Doi = {10.1002/ana.24520},
Key = {fds333035}
}
@article{fds299401,
Author = {Anderson, LM and Allen, TM and Thornburg, CD and Bonner,
MJ},
Title = {Fatigue in Children With Sickle Cell Disease: Association
With Neurocognitive and Social-Emotional Functioning and
Quality of Life.},
Journal = {J Pediatr Hematol Oncol},
Volume = {37},
Number = {8},
Pages = {584-589},
Year = {2015},
Month = {November},
ISSN = {1077-4114},
url = {http://dx.doi.org/10.1097/MPH.0000000000000431},
Abstract = {Children with sickle cell disease (SCD) report fatigue in
addition to acute and chronic pain, which can decrease
overall health-related quality of life (HRQL). The primary
objective of the current study was to investigate the
relationship between fatigue and HRQL. Given limited prior
research, secondary objectives included investigation of
associations between fatigue and functional outcomes,
including child neurocognitive and social-emotional
functioning. Children aged 8 to 16 years (N=32) and a
caregiver completed measures of fatigue, HRQL, pain, and
neurocognitive and social-emotional functioning. Controlling
for pain and number of SCD-related hospitalizations,
hierarchical linear regression models were used to determine
the impact of child-reported and parent-reported fatigue on
child HRQL. Correlational analyses were used to explore the
relationship between fatigue and additional child outcomes.
Data indicated that children with SCD experience clinically
relevant levels of fatigue, which independently predicts
lower HRQL. Fatigue was also associated with lower working
memory, executive functioning, and higher levels of
internalizing symptoms. Given its observed impact on HRQL
and relationship to functional outcomes, fatigue may be an
important target of clinical, home, or school interventions.
This practice may attenuate the burden of fatigue in these
patients, and in turn, help improve the quality of life of
children living with SCD.},
Doi = {10.1097/MPH.0000000000000431},
Key = {fds299401}
}
@article{fds299403,
Author = {Shashi, V and Harrell, W and Eack, S and Sanders, C and McConkie-Rosell,
A and Keshavan, MS and Bonner, MJ and Schoch, K and Hooper,
SR},
Title = {Social cognitive training in adolescents with chromosome
22q11.2 deletion syndrome: feasibility and preliminary
effects of the intervention.},
Journal = {J Intellect Disabil Res},
Volume = {59},
Number = {10},
Pages = {902-913},
Year = {2015},
Month = {October},
ISSN = {0964-2633},
url = {http://dx.doi.org/10.1111/jir.12192},
Abstract = {BACKGROUND: Children with chromosome 22q11.2 deletion
syndrome (22q11DS) often have deficits in social cognition
and social skills that contribute to poor adaptive
functioning. These deficits may be of relevance to the later
occurrence of serious psychiatric illnesses such as
schizophrenia. Yet, there are no evidence-based
interventions to improve social cognitive functioning in
children with 22q11DS. METHODS: Using a customised social
cognitive curriculum, we conducted a pilot small-group-based
social cognitive training (SCT) programme in 13 adolescents
with 22q11DS, relative to a control group of nine age- and
gender-matched adolescents with 22q11DS. RESULTS: We found
the SCT programme to be feasible, with high rates of
compliance and satisfaction on the part of the participants
and their families. Our preliminary analyses indicated that
the intervention group showed significant improvements in an
overall social cognitive composite index. CONCLUSIONS: SCT
in a small-group format for adolescents with 22q11DS is
feasible and results in gains in social cognition. A larger
randomised controlled trial would permit assessment of
efficacy of this promising novel intervention.},
Doi = {10.1111/jir.12192},
Key = {fds299403}
}
@article{fds299402,
Author = {Hardy, KK and Willard, VW and Wigdor, AB and Allen, TM and Bonner,
MJ},
Title = {The potential utility of parent-reported attention screening
in survivors of childhood cancer to identify those in need
of comprehensive neuropsychological evaluation.},
Journal = {Neurooncol Pract},
Volume = {2},
Number = {1},
Pages = {32-39},
Year = {2015},
Month = {March},
ISSN = {2054-2577},
url = {http://dx.doi.org/10.1093/nop/npu026},
Abstract = {BACKGROUND: Survivors of childhood cancer are at risk for
neuropsychological late effects, yet identifying those in
need of evaluation and obtaining needed services can be
challenging for the medical team. Finding time- and
cost-effective screening measures that can be used to
identify children in need of evaluation is a clinical
priority. Our objective was to investigate the association
between parent-rated attention problems and related
neuropsychological impairments in childhood cancer survivors
as a means of identifying those at high risk for
difficulties. METHODS: Cognitive and psychosocial data of
survivors who completed neuropsychological evaluations were
retrospectively abstracted. Parents of 70 survivors of
pediatric cancer (mean age, 11.6 years) completed the
Conners Parent Rating Scale and the Child Behavior
Checklist. Children also completed a measure of intellectual
functioning. The 18 symptoms of inattention and
hyperactivity were abstracted from the Conners
questionnaire, and participants were classified according to
whether or not they met attention deficit/hyperactivity
disorder (ADHD) symptom criteria (≥6 inattentive
symptoms). RESULTS: Survivors who met symptom criteria for
ADHD (27%) demonstrated greater impairments in IQ and
working memory, but not processing speed, than survivors who
did not. Meeting ADHD symptom criteria was also associated
with greater externalizing and social problems but not more
internalizing symptoms. ADHD symptom screening was
associated with low sensitivity (range = 26.3%-69.2%) but
stronger specificity (range = 75.0%-82.7%) for
neuropsychological difficulties. CONCLUSION: Parental
ratings of attentional symptoms may be a useful way to
screen survivors who may be in need of a full
neuropsychological assessment.},
Doi = {10.1093/nop/npu026},
Key = {fds299402}
}
@article{fds271051,
Author = {Schreiber, JE and Gurney, JG and Palmer, SL and Bass, JK and Wang, M and Chen, S and Zhang, H and Swain, M and Chapieski, ML and Bonner, MJ and Mabbott, DJ and Knight, SJ and Armstrong, CL and Boyle, R and Gajjar,
A},
Title = {Examination of risk factors for intellectual and academic
outcomes following treatment for pediatric
medulloblastoma.},
Journal = {Neuro Oncol},
Volume = {16},
Number = {8},
Pages = {1129-1136},
Year = {2014},
Month = {August},
ISSN = {1522-8517},
url = {http://dx.doi.org/10.1093/neuonc/nou006},
Abstract = {BACKGROUND: The aim of this study was to prospectively
examine the effects of hearing loss and posterior fossa
syndrome (PFS), in addition to age at diagnosis and disease
risk status, on change in intellectual and academic outcomes
following diagnosis and treatment in a large sample of
medulloblastoma patients. METHODS: Data from at least 2
cognitive and academic assessments were available from 165
patients (ages 3-21 years) treated with surgery,
risk-adapted craniospinal irradiation, and 4 courses of
chemotherapy with stem cell support. Patients underwent
serial evaluation of cognitive and academic functioning from
baseline up to 5 years post diagnosis. RESULTS: Serious
hearing loss, PFS, younger age at diagnosis, and high-risk
status were all significant risk factors for decline in
intellectual and academic skills. Serious hearing loss and
PFS independently predicted below-average estimated mean
intellectual ability at 5 years post diagnosis. Patients
with high-risk medulloblastoma and young age at diagnosis
(<7 years) exhibited the largest drop in mean scores for
intellectual and academic outcomes. CONCLUSIONS: Despite a
significant decline over time, intellectual and academic
outcomes remained within the average range at 5 years post
diagnosis for the majority of patients. Future studies
should determine if scores remain within the average range
at time points further out from treatment. Patients at
heightened risk should be closely monitored and provided
with recommendations for appropriate interventions.},
Doi = {10.1093/neuonc/nou006},
Key = {fds271051}
}
@article{fds271045,
Author = {Knight, SJ and Conklin, HM and Palmer, SL and Schreiber, JE and Armstrong, CL and Wallace, D and Bonner, M and Swain, MA and Evankovich,
KD and Mabbott, DJ and Boyle, R and Huang, Q and Zhang, H and Anderson, VA and Gajjar, A},
Title = {Working memory abilities among children treated for
medulloblastoma: parent report and child
performance.},
Journal = {J Pediatr Psychol},
Volume = {39},
Number = {5},
Pages = {501-511},
Year = {2014},
Month = {June},
ISSN = {0146-8693},
url = {http://dx.doi.org/10.1093/jpepsy/jsu009},
Abstract = {OBJECTIVE: We investigated the 5-year postsurgical
developmental trajectory of working memory (WM) in children
with medulloblastoma using parent and performance-based
measures. METHOD: This study included 167 patients treated
for medulloblastoma. Serial assessments of WM occurred at
predetermined time points for 5 years. RESULTS: There was a
subtle, statistically significant increase in parental
concern about WM, coupled with a statistically significant
decrease in age-standardized scores on performance-based
measures. However, whole-group mean scores on both parent
and performance-based measures remained in the age-expected
range. Posterior fossa syndrome was consistently associated
with poorer WM. Younger age at treatment and higher
treatment intensity were associated with greater negative
change in WM performance only. CONCLUSIONS: Most children
treated for medulloblastoma display WM within the
age-appropriate range according to parent report and
performance. However, the subtle negative changes over time
and identified subgroups at increased risk highlight the
need for ongoing monitoring of this population.},
Doi = {10.1093/jpepsy/jsu009},
Key = {fds271045}
}
@article{fds271046,
Author = {Reddick, WE and Taghipour, DJ and Glass, JO and Ashford, J and Xiong, X and Wu, S and Bonner, M and Khan, RB and Conklin, HM},
Title = {Prognostic factors that increase the risk for reduced white
matter volumes and deficits in attention and learning for
survivors of childhood cancers.},
Journal = {Pediatr Blood Cancer},
Volume = {61},
Number = {6},
Pages = {1074-1079},
Year = {2014},
Month = {June},
ISSN = {1545-5009},
url = {http://dx.doi.org/10.1002/pbc.24947},
Abstract = {OBJECTIVE: In children, CNS-directed cancer therapy is
thought to result in decreased cerebral white matter volumes
(WMV) and subsequent neurocognitive deficits. This study was
designed as a prospective validation of the purported
reduction in WMV, associated influential factors, and its
relationship to neurocognitive deficits in a very large
cohort of both acute lymphoblastic leukemia (ALL) and
malignant brain tumors (BT) survivors in comparison to an
age similar cohort of healthy sibling controls. PROCEDURES:
The effects of host characteristics and CNS treatment
intensity on WMV were investigated in 383 childhood cancer
survivors (199 ALL, 184 BT) at least 12 months
post-completion of therapy and 67 healthy siblings that
served as a control group. t-Tests and multiple variable
linear models were used to assess cross-sectional WMV and
its relation with neurocognitive function. RESULTS: BT
survivors had lower WMV than ALL survivors, who had less
than the control group. Increased CNS treatment intensity,
younger age at treatment, and greater time since treatment
were significantly associated with lower WMV. Additionally,
cancer survivors did not perform as well as the control
group on neurocognitive measures of intelligence, attention,
and academic achievement. Reduced WMV had a larger impact on
estimated IQ among females and children treated at a younger
age. CONCLUSIONS: Survivors of childhood cancer that have
undergone higher intensity therapy at a younger age have
significantly less WMV than their peers and this difference
increases with time since therapy. Decreased WMV is
associated with significantly lower scores in intelligence,
attention, and academic performance in survivors.},
Doi = {10.1002/pbc.24947},
Key = {fds271046}
}
@article{fds271047,
Author = {Anderson, LM and Allen, TM and Nambuba, J and Thornburg, CD and Bonner,
MJ},
Title = {Predictors of Fatigue in Children with Sickle Cell
Disease},
Journal = {JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS},
Volume = {35},
Number = {2},
Pages = {S12-S12},
Publisher = {LIPPINCOTT WILLIAMS & WILKINS},
Year = {2014},
Month = {February},
ISSN = {0196-206X},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000336849800047&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds271047}
}
@article{fds271048,
Author = {Allen, TM and Anderson, LM and Nambuba, J and Thornburg, CD and Bonner,
MJ},
Title = {The Impact of Cognitive Functioning on Quality of Life in
Children with Sickle Cell Disease},
Journal = {JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS},
Volume = {35},
Number = {2},
Pages = {S11-S11},
Publisher = {LIPPINCOTT WILLIAMS & WILKINS},
Year = {2014},
Month = {February},
ISSN = {0196-206X},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000336849800042&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds271048}
}
@article{fds271049,
Author = {Serafini, S and Komisarow, JM and Gallentine, W and Mikati, MA and Bonner, MJ and Kranz, PG and Haglund, MM and Grant,
G},
Title = {Reorganization and stability for motor and language areas
using cortical stimulation: case example and review of the
literature.},
Journal = {Brain Sci},
Volume = {3},
Number = {4},
Pages = {1597-1614},
Year = {2013},
Month = {November},
url = {http://dx.doi.org/10.3390/brainsci3041597},
Abstract = {The cerebral organization of language in epilepsy patients
has been studied with invasive procedures such as Wada
testing and electrical cortical stimulation mapping and more
recently with noninvasive neuroimaging techniques, such as
functional MRI. In the setting of a chronic seizure
disorder, clinical variables have been shown to contribute
to cerebral language reorganization underscoring the need
for language lateralization and localization procedures. We
present a 14-year-old pediatric patient with a refractory
epilepsy disorder who underwent two neurosurgical resections
of a left frontal epileptic focus separated by a year. He
was mapped extraoperatively through a subdural grid using
cortical stimulation to preserve motor and language
functions. The clinical history and extensive workup prior
to surgery is discussed as well as the opportunity to
compare the cortical maps for language, motor, and sensory
function before each resection. Reorganization in cortical
tongue sensory areas was seen concomitant with a new zone of
ictal and interictal activity in the previous tongue sensory
area. Detailed neuropsychological data is presented before
and after any surgical intervention to hypothesize about the
extent of reorganization between epochs. We conclude that
intrahemispheric cortical plasticity does occur following
frontal lobe resective surgery in a teenager with medically
refractory seizures.},
Doi = {10.3390/brainsci3041597},
Key = {fds271049}
}
@article{fds271054,
Author = {Alvarez, O and Yovetich, NA and Scott, JP and Owen, W and Miller, ST and Schultz, W and Lockhart, A and Aygun, B and Flanagan, J and Bonner, M and Mueller, BU and Ware, RE and Investigators of the Stroke With
Transfusions Changing to Hydroxyurea Clinical Trial
(SWiTCH)},
Title = {Pain and other non-neurological adverse events in children
with sickle cell anemia and previous stroke who received
hydroxyurea and phlebotomy or chronic transfusions and
chelation: results from the SWiTCH clinical
trial.},
Journal = {Am J Hematol},
Volume = {88},
Number = {11},
Pages = {932-938},
Year = {2013},
Month = {November},
ISSN = {0361-8609},
url = {http://dx.doi.org/10.1002/ajh.23547},
Abstract = {To compare the non-neurological events in children with
sickle cell anemia (SCA) and previous stroke enrolled in
SWiTCH. The NHLBI-sponsored Phase III multicenter randomized
clinical trial stroke with transfusions changing to
hydroxyurea (SWiTCH) (ClinicalTrials.gov NCT00122980)
compared continuation of chronic blood transfusion/iron
chelation to switching to hydroxyurea/phlebotomy for
secondary stroke prevention and management of iron overload.
All randomized children were included in the analysis
(intention to treat). The Fisher's Exact test was used to
compare the frequency of subjects who experienced at least
one SCA-related adverse event (AE) or serious adverse event
(SAE) in each arm and to compare event rates. One hundred
and thirty three subjects, mean age 13 ± 3.9 years (range
5.2-19.0 years) and mean time of 7 years on chronic
transfusion at study entry, were randomized and treated.
Numbers of subjects experiencing non-neurological AEs were
similar in the two treatment arms, including SCA-related
events, SCA pain events, and low rates of acute chest
syndrome and infection. However, fewer children continuing
transfusion/chelation experienced SAEs (P = 0.012),
SCA-related SAEs (P = 0.003), and SCA pain SAEs (P = 0.016)
as compared to children on the hydroxyurea/phlebotomy arm.
The timing of phlebotomy did not influence SAEs. Older age
at baseline predicted having at least 1 SCA pain event.
Patients with recurrent neurological events during SWiTCH
were not more likely to experience pain. In children with
SCA and prior stroke, monthly transfusions and daily iron
chelation provided superior protection against acute
vaso-occlusive pain SAEs when compared to hydroxyurea and
monthly phlebotomy.},
Doi = {10.1002/ajh.23547},
Key = {fds271054}
}
@article{fds271057,
Author = {Palmer, SL and Armstrong, C and Onar-Thomas, A and Wu, S and Wallace, D and Bonner, MJ and Schreiber, J and Swain, M and Chapieski, L and Mabbott,
D and Knight, S and Boyle, R and Gajjar, A},
Title = {Processing speed, attention, and working memory after
treatment for medulloblastoma: an international,
prospective, and longitudinal study.},
Journal = {J Clin Oncol},
Volume = {31},
Number = {28},
Pages = {3494-3500},
Year = {2013},
Month = {October},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23980078},
Abstract = {PURPOSE: The current study prospectively examined processing
speed (PS), broad attention (BA), and working memory (WM)
ability of patients diagnosed with medulloblastoma over a
5-year period. PATIENTS AND METHODS: The study included 126
patients, ages 3 to 21 years at diagnosis, enrolled onto a
collaborative protocol for medulloblastoma. Patients were
treated with postsurgical risk-adapted craniospinal
irradiation (n = 36 high risk [HR]; n = 90 average risk)
followed by four cycles of high-dose chemotherapy with
stem-cell support. Patients completed 509 neuropsychological
evaluations using the Woodcock-Johnson Tests of Cognitive
Abilities Third Edition (median of three observations per
patient). RESULTS: Linear mixed effects models revealed that
younger age at diagnosis, HR classification, and higher
baseline scores were significantly associated with poorer
outcomes in PS. Patients treated as HR and those with higher
baseline scores are estimated to have less favorable
outcomes in WM and BA over time. Parent education and
marital status were significantly associated with BA and WM
baseline scores but not change over time. CONCLUSION: Of the
three key domains, PS was estimated to have the lowest
scores at 5 years after diagnosis. Identifying cognitive
domains most vulnerable to decline should guide researchers
who are aiming to develop efficacious cognitive intervention
and rehabilitation programs, thereby improving the quality
of survivorship for the pediatric medulloblastoma
population.},
Doi = {10.1200/JCO.2012.47.4775},
Key = {fds271057}
}
@article{fds271053,
Author = {Harrell, W and Eack, S and Hooper, SR and Keshavan, MS and Bonner, MS and Schoch, K and Shashi, V},
Title = {Feasibility and preliminary efficacy data from a
computerized cognitive intervention in children with
chromosome 22q11.2 deletion syndrome.},
Journal = {Res Dev Disabil},
Volume = {34},
Number = {9},
Pages = {2606-2613},
Year = {2013},
Month = {September},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23751300},
Abstract = {Children with chromosome 22q11.2 deletion syndrome (22q11DS)
are significantly impaired in their academic performance and
functionality due to cognitive deficits, especially in
attention, memory, and other facets of executive function.
Compounding these cognitive deficits is the remarkably high
risk of major psychoses, occurring in 25% of adolescents and
adults with the disorder. There are currently no
evidence-based interventions designed to improve the
cognitive deficits in these individuals. We implemented a
neuroplasticity-based computerized cognitive remediation
program for 12 weeks in 13 adolescents with 22q11DS,
assessed feasibility, and measured changes in cognition
before and after the intervention compared to a control
group of 10 age- and gender-matched children with 22q11DS.
Our results indicated that despite their cognitive
impairments, this intervention is feasible in children with
22q11DS, with high rates of adherence and satisfaction. Our
preliminary analyses indicate that gains in cognition occur
with the intervention. Further study in a larger randomized
controlled trial would enable assessment of efficacy of this
novel intervention.},
Doi = {10.1016/j.ridd.2013.05.009},
Key = {fds271053}
}
@article{fds271090,
Author = {Hardy, KK and Willard, VW and Allen, TM and Bonner,
MJ},
Title = {Working memory training in survivors of pediatric cancer: a
randomized pilot study.},
Journal = {Psychooncology},
Volume = {22},
Number = {8},
Pages = {1856-1865},
Year = {2013},
Month = {August},
ISSN = {1057-9249},
url = {http://dx.doi.org/10.1002/pon.3222},
Abstract = {OBJECTIVES: Survivors of pediatric brain tumors and acute
lymphoblastic leukemia (ALL) are at increased risk for
neurocognitive deficits, but few empirically supported
treatment options exist. We examined the feasibility and
preliminary efficacy of a home-based, computerized working
memory training program, CogmedRM, with survivors of
childhood cancer. METHODS: Survivors of brain tumors or ALL
(n = 20) with identified deficits in attention and/or
working memory were randomized to either the success-adapted
computer intervention or a non-adaptive, active control
condition. Specifically, children in the adaptive condition
completed exercises that became more challenging with each
correct trial, whereas those in the non-adaptive version
trained with exercises that never increased in difficulty.
All participants were asked to complete 25 training sessions
at home, with weekly, phone-based coaching support. Brief
assessments were completed pre-intervention and
post-intervention; outcome measures included both
performance-based and parent-report measures of working
memory and attention. RESULTS: Eighty-five percent of
survivors were compliant with the intervention, with no
adverse events reported. After controlling for baseline
intellectual functioning, survivors who completed the
intervention program evidenced significant post-training
improvements in their visual working memory and in
parent-rated learning problems compared with those in the
active control group. No differences in verbal working
memory functioning were evident between groups, however.
CONCLUSIONS: Home-based, computerized cognitive training
demonstrates good feasibility and acceptability in our
sample. Children with higher intellectual functioning at
baseline appeared to benefit more from the training,
although further study is needed to clarify the strength,
scope, and particularly the generalizability of potential
treatment effects.},
Doi = {10.1002/pon.3222},
Key = {fds271090}
}
@article{fds271050,
Author = {Anderson, LM and Allen, TM and Andrzejewski, L and Thornburg, CD and Bonner, MJ},
Title = {Fatigue in Children with Sickle Cell Disease: Impact on
Quality of Life},
Journal = {JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS},
Volume = {34},
Number = {6},
Pages = {S1-S1},
Publisher = {LIPPINCOTT WILLIAMS & WILKINS},
Year = {2013},
Month = {July},
ISSN = {0196-206X},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330358800004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds271050}
}
@article{fds271094,
Author = {Brinkman, TM and Palmer, SL and Chen, S and Zhang, H and Evankovich, K and Swain, MA and Bonner, MJ and Janzen, L and Knight, S and Armstrong, CL and Boyle, R and Gajjar, A},
Title = {Parent-reported social outcomes after treatment for
pediatric embryonal tumors: a prospective longitudinal
study.},
Journal = {J Clin Oncol},
Volume = {30},
Number = {33},
Pages = {4134-4140},
Year = {2012},
Month = {November},
ISSN = {0732-183X},
url = {http://dx.doi.org/10.1200/JCO.2011.40.6702},
Abstract = {PURPOSE: To examine longitudinal parent-reported social
outcomes for children treated for pediatric embryonal brain
tumors. PATIENTS AND METHODS: Patients (N=220) were enrolled
onto a multisite clinical treatment protocol. Parents
completed the Child Behavior Checklist/6-18 at the time of
their child's diagnosis and yearly thereafter. A generalized
linear mixed effects model regression approach was used to
examine longitudinal changes in parent ratings of social
competence, social problems, and withdrawn/depressed
behaviors with demographic and treatment factors as
covariates. RESULTS: During the 5-year period following
diagnosis and treatment, few patients were reported to have
clinically elevated scores on measures of social
functioning. Mean scores differed significantly from
population norms, yet remained within the average range.
Several factors associated with unfavorable patterns of
change in social functioning were identified. Patients with
high-risk treatment status had a greater increase in
parent-reported social problems (P=.001) and
withdrawn/depressed behaviors (P=.01) over time compared
with average-risk patients. Patients with posterior fossa
syndrome had greater parent-reported social problems over
time (P=.03). Female patients showed higher
withdrawn/depressed scores over time compared with male
patients (P<.001). Patient intelligence, age at diagnosis,
and parent education level also contributed to parent report
of social functioning. CONCLUSION: Results of this study
largely suggest positive social adjustment several years
after diagnosis and treatment of a pediatric embryonal
tumor. However, several factors, including treatment risk
status and posterior fossa syndrome, may be important
precursors of long-term social outcomes. Future research is
needed to elucidate the trajectory of social functioning as
these patients transition into adulthood.},
Doi = {10.1200/JCO.2011.40.6702},
Key = {fds271094}
}
@article{fds271097,
Author = {Brown, RT and Shaftman, SR and Tilley, BC and Anthony, KK and Kral, MC and Maxson, B and Mee, L and Bonner, MJ and Vogler, LB and Schanberg, LE and Connelly, MA and Wagner, JL and Silver, RM and Nietert,
PJ},
Title = {The health education for lupus study: a randomized
controlled cognitive-behavioral intervention targeting
psychosocial adjustment and quality of life in adolescent
females with systemic lupus erythematosus.},
Journal = {Am J Med Sci},
Volume = {344},
Number = {4},
Pages = {274-282},
Year = {2012},
Month = {October},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22996139},
Abstract = {INTRODUCTION: To examine in a randomize controlled
feasibility clinical trial the efficacy of a
cognitive-behavioral intervention designed to manage pain,
enhance disease adjustment and adaptation and improve
quality of life among female adolescents with systemic lupus
erythematosus. METHODS: Female adolescents (n = 53) ranging
in age from 12 to 18 years were randomly assigned to 1 of 3
groups including a cognitive-behavioral intervention, an
education-only arm and a no-contact control group.
Participants were assessed at baseline, postintervention and
at 3- and 6-month intervals after completion of the
intervention. RESULTS: No significant differences were
revealed among the 3 treatment arms for any of the dependent
measures at any of the assessment points. For the mediator
variables, a posthoc secondary analysis did reveal increases
in coping skills from baseline to postintervention among the
participants in the cognitive-behavioral intervention group
compared with both the no-contact control group and the
education-only group. CONCLUSION: Although no differences
were detected in the primary outcome, a possible effect on
coping of female adolescents with systemic lupus
erythematosus was detected in this feasibility study.
Whether the impact of training in the area of coping was of
sufficient magnitude to generalize to other areas of
functioning, such as adjustment and adaptation, is unclear.
Future phase III randomized trials will be needed to assess
additional coping models and to evaluate the dose of
training and its influence on pain management, adjustment
and health-related quality of life.},
Doi = {10.1097/MAJ.0b013e3182449be9},
Key = {fds271097}
}
@article{fds271093,
Author = {Ashley, DM and Merchant, TE and Strother, D and Zhou, T and Duffner, P and Burger, PC and Miller, DC and Lyon, N and Bonner, MJ and Msall, M and Buxton, A and Geyer, R and Kun, LE and Coleman, L and Pollack,
IF},
Title = {Induction chemotherapy and conformal radiation therapy for
very young children with nonmetastatic medulloblastoma:
Children's Oncology Group study P9934.},
Journal = {J Clin Oncol},
Volume = {30},
Number = {26},
Pages = {3181-3186},
Year = {2012},
Month = {September},
ISSN = {0732-183X},
url = {http://dx.doi.org/10.1200/JCO.2010.34.4341},
Abstract = {PURPOSE: P9934 was a prospective trial of systemic
chemotherapy, second surgery, and conformal radiation
therapy (CRT) limited to the posterior fossa and primary
site for children between 8 months and 3 years old with
nonmetastatic medulloblastoma. The study was open from June
2000 until June 2006. PATIENTS AND METHODS: After initial
surgery, children received four cycles of induction
chemotherapy, followed by age- and response-adjusted CRT to
the posterior fossa (18 or 23.4 Gy) and tumor bed
(cumulative 50.4 or 54 Gy) and maintenance chemotherapy.
Neurodevelopmental outcomes were evaluated and event-free
survival (EFS) results were directly compared with a
previous study of multiagent chemotherapy without
irradiation (Pediatric Oncology Group [POG] trial 9233).
RESULTS: Seventy-four patients met eligibility requirements.
The 4-year EFS and overall survival probabilities were 50%
± 6% and 69% ± 5.5%, respectively, which compared
favorably to the results from POG 9233. Analysis showed that
the desmoplastic/nodular subtype was a favorable factor in
predicting survival. Our 4-year EFS rate was 58% ± 8% for
patients with desmoplasia. Whereas seven of 10 patients who
had disease progression before CRT had primary-site failure,
15 of 19 patients who progressed after CRT had distant-site
failure. Neurodevelopmental assessments did not show a
decline in cognitive or motor function after
protocol-directed chemotherapy and CRT. CONCLUSION: The
addition of CRT to postoperative chemotherapy in young
children with nonmetastatic medulloblastoma increased
event-free survival compared with the use of postoperative
chemotherapy alone. Future studies will use histopathologic
typing (desmoplastic/nodular versus nondesmoplastic/nodular)
to stratify patients for therapy by risk of
relapse.},
Doi = {10.1200/JCO.2010.34.4341},
Key = {fds271093}
}
@article{fds271092,
Author = {Panepinto, JA and Bonner, M},
Title = {Health-related quality of life in sickle cell disease: past,
present, and future.},
Journal = {Pediatr Blood Cancer},
Volume = {59},
Number = {2},
Pages = {377-385},
Year = {2012},
Month = {August},
ISSN = {1545-5009},
url = {http://dx.doi.org/10.1002/pbc.24176},
Abstract = {Health-related quality of life (HRQL) is defined as the
patient's appraisal of how his/her well being and level of
functioning, compared to the perceived ideal, are affected
by individual health. The study of HRQL in children and
adults with sickle cell disease (SCD) has begun to flourish.
Given the devastating complications of the disease and other
co-morbid factors patients experience that influence HRQL,
it is increasingly important to understand HRQL. The focus
of this critical review was to examine past and current
research in HRQL in SCD where a validated instrument was
used. In addition, future directions for HRQL in SCD are
explored.},
Doi = {10.1002/pbc.24176},
Key = {fds271092}
}
@article{fds271091,
Author = {Palmer, SL and Lesh, S and Wallace, D and Bonner, MJ and Swain, M and Chapieski, L and Janzen, L and Mabbott, D and Knight, S and Boyle, R and Armstrong, CL and Gajjar, A},
Title = {How parents cope with their child's diagnosis and treatment
of an embryonal tumor: results of a prospective and
longitudinal study.},
Journal = {J Neurooncol},
Volume = {105},
Number = {2},
Pages = {253-259},
Year = {2011},
Month = {November},
ISSN = {0167-594X},
url = {http://dx.doi.org/10.1007/s11060-011-0574-9},
Abstract = {The current study reports longitudinal coping responses
among parents of children diagnosed with an embryonal brain
tumor. Patients (n = 219) were enrolled on a treatment
protocol for a pediatric embryonal brain tumor. Their
parents (n = 251) completed the Coping Response Inventory at
time of their child's diagnosis and yearly thereafter,
resulting in 502 observations. Outcomes were examined with
patient and parent age at diagnosis, patient risk, parent
gender and education as covariates. At the time of
diagnosis, the highest observed coping method was seeking
guidance with well above average scores (T = 61.6). Over
time, younger parents were found to seek guidance at a
significantly higher rate than older parents (P = .016) and
the use of acceptance resignation and seeking alternative
results by all parents significantly increased (P = .011 and
P < .0001 respectively). The use of emotional discharge was
also observed above average at time of diagnosis (T = 55.4)
with younger fathers being more likely to exhibit emotional
discharge than older fathers (P = .002). Differences in
coping according to age of the patient and parent education
level are also discussed. Results show a high need for
guidance, and above average emotional discharge, especially
among younger parents. It is imperative for the healthcare
team to lead with accurate information so that these parents
may make informed decisions about the care of their child.
This need remains high years after diagnosis. Therefore it
is critical to continue a consistent level of effective
communication and support, even following
treatment.},
Doi = {10.1007/s11060-011-0574-9},
Key = {fds271091}
}
@article{fds271088,
Author = {Hubal, RC and Bonner, MJ and Hardy, KK and Fitzgerald, DP and Willard,
VW and Allen, TM},
Title = {Technical aspects and testing of a program to assess
deficits in facial expression recognition in childhood
cancer survivors},
Journal = {Journal of Cyber Therapy and Rehabilitation},
Volume = {4},
Number = {3},
Pages = {363-369},
Year = {2011},
Month = {October},
ISSN = {1784-9934},
Abstract = {The research presented here focuses on the ease of use of an
instrument's interface for a target pediatric population,
where participants were asked to interpret virtual character
facial expressions. Fortyone children, both pediatric cancer
survivors and healthy recruits, took part in six tasks that
had them describe or express their confidence in
descriptions of different facial expressions, portrayed
either overtly or subtly and dynamically or statically by
eight virtual characters. In this test of usability and
feasibility, childhood cancer survivors performed comparably
to healthy participants, suggesting that this instrument is
feasible for use with cancer patients. © Virtual Reality
Medical Institute.},
Key = {fds271088}
}
@article{fds271067,
Author = {Allen, TM and Willard, VW and Hardy, KK and Bonner,
MJ},
Title = {THE RELATIONSHIP BETWEEN NEUROCOGNITIVE ABILITY AND
PSYCHOSOCIAL FUNCTIONING IN CHILDREN WITH NEUROFIBROMATOSIS
TYPE 1},
Journal = {ANNALS OF BEHAVIORAL MEDICINE},
Volume = {41},
Pages = {S180-S180},
Publisher = {SPRINGER},
Year = {2011},
Month = {April},
ISSN = {0883-6612},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000289297701189&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds271067}
}
@article{fds271086,
Author = {Hardy, KK and Willard, VW and Bonner, MJ},
Title = {Computerized cognitive training in survivors of childhood
cancer: a pilot study.},
Journal = {J Pediatr Oncol Nurs},
Volume = {28},
Number = {1},
Pages = {27-33},
Year = {2011},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20966158},
Abstract = {The objective of the current study was to pilot a
computerized cognitive training program, Captain's Log, in a
small sample of survivors of childhood cancer. A total of 9
survivors of acute lymphoblastic leukemia and brain tumors
with attention and working memory deficits were enrolled in
a home-based 12-week cognitive training program. Survivors
returned for follow-up assessments postintervention and 3
months later. The intervention was associated with good
feasibility and acceptability. Participants exhibited
significant increases in working memory and decreases in
parent-rated attention problems following the intervention.
Findings indicate that home-based, computerized cognitive
intervention is a promising intervention for survivors with
cognitive late effects; however, further study is warranted
with a larger sample.},
Doi = {10.1177/1043454210377178},
Key = {fds271086}
}
@article{fds271087,
Author = {Palmer, SL and Hassall, T and Evankovich, K and Mabbott, DJ and Bonner,
M and Deluca, C and Cohn, R and Fisher, MJ and Morris, EB and Broniscer, A and Gajjar, A},
Title = {Neurocognitive outcome 12 months following cerebellar mutism
syndrome in pediatric patients with medulloblastoma.},
Journal = {Neuro Oncol},
Volume = {12},
Number = {12},
Pages = {1311-1317},
Year = {2010},
Month = {December},
ISSN = {1522-8517},
url = {http://dx.doi.org/10.1093/neuonc/noq094},
Abstract = {The aim is to prospectively assess early neurocognitive
outcome of children who developed cerebellar mutism syndrome
(CMS) following surgical resection of a posterior fossa
embryonal tumor, compared with carefully matched control
patients. Children who were enrolled on an ongoing
IRB-approved protocol for treatment of embryonal tumors,
were diagnosed with postoperative CMS, and had completed
prospectively planned neuropsychological evaluation at 12
months postdiagnosis were considered eligible. The cognitive
outcomes of these patients were examined in comparison to
patients without CMS from the same treatment protocol and
matched with regard to primary diagnosis, age at diagnosis,
and risk/corresponding treatment (n = 22 pairs). Seventeen
were also matched according to gender, and 14 were also
matched according to race. High-risk patients received
36-39.6 Gy CSI and 3D conformal boost to the primary site to
55.8-59.4 Gy. Average-risk patients received 23.4 Gy CSI and
3D conformal boost to the primary site to 55.8 Gy.
Significant group differences were found on multiple
cognitive outcomes. While the matched control patients
exhibited performance in the average range, patients who
developed CMS postsurgery were found to have significantly
lower performance in processing speed, attention, working
memory, executive processes, cognitive efficiency, reading,
spelling, and math. Patients treated for medulloblastoma who
experience postoperative CMS show an increased risk for
neurocognitive impairment, evident as early as 12 months
following diagnosis. This study highlights the need for
careful follow-up with neuropsychological evaluation and for
obtaining critical support for patients and their
families.},
Doi = {10.1093/neuonc/noq094},
Key = {fds271087}
}
@article{fds271085,
Author = {Conklin, HM and Reddick, WE and Ashford, J and Ogg, S and Howard, SC and Morris, EB and Brown, R and Bonner, M and Christensen, R and Wu, S and Xiong, X and Khan, RB},
Title = {Long-term efficacy of methylphenidate in enhancing attention
regulation, social skills, and academic abilities of
childhood cancer survivors.},
Journal = {J Clin Oncol},
Volume = {28},
Number = {29},
Pages = {4465-4472},
Year = {2010},
Month = {October},
ISSN = {0732-183X},
url = {http://dx.doi.org/10.1200/JCO.2010.28.4026},
Abstract = {PURPOSE: Methylphenidate (MPH) ameliorates attention
problems experienced by some cancer survivors in the short
term, but its long-term efficacy is unproven. PATIENTS AND
METHODS: This study investigates the long-term effectiveness
of maintenance doses of MPH in survivors of childhood brain
tumors (n = 35) and acute lymphoblastic leukemia (n = 33)
participating in a 12-month MPH trial. Measures of attention
(Conners' Continuous Performance Test [CPT], Conners' Rating
Scales [CRS]), academic abilities (Wechsler Individual
Achievement Test [WIAT]), social skills (Social Skills
Rating System [SSRS]), and behavioral problems (Child
Behavior Checklist [CBCL]) were administered at
premedication baseline and at the end of the MPH trial while
on medication. A cancer control group composed of patients
who were not administered MPH (brain tumor = 31 and acute
lymphoblastic leukemia = 23) was assessed on the same
measures 12 [corrected] months apart. RESULTS: For the MPH
group, repeated measures analysis of variance revealed
significant improvement in performance on a measure of
sustained attention (CPT indices, P < .05); parent, teacher,
and self-report ratings of attention (CRS indices, P < .05),
and parent ratings of social skills or behavioral problems
(SSRS and CBCL indices; P < .05). In contrast, the cancer
control group only showed improvement on parent ratings of
attention (Conners' Parent Rating Scale indices; P < .05)
and social skills (SSRS and CBCL indices; P < .05). There
was no significant improvement on the academic measure
(WIAT) in either group. CONCLUSION: Attention and behavioral
benefits of MPH for childhood cancer survivors are
maintained across settings over the course of a year.
Although academic gains were not identified, MPH may offer
benefits in academic areas not assessed.},
Doi = {10.1200/JCO.2010.28.4026},
Key = {fds271085}
}
@article{fds271084,
Author = {Paxton, RJ and Jones, LW and Rosoff, PM and Bonner, M and Ater, JL and Demark-Wahnefried, W},
Title = {Associations between leisure-time physical activity and
health-related quality of life among adolescent and adult
survivors of childhood cancers.},
Journal = {Psychooncology},
Volume = {19},
Number = {9},
Pages = {997-1003},
Year = {2010},
Month = {September},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19918964},
Abstract = {OBJECTIVE: Survivors of childhood cancer are at an increased
risk for reduced quality of life (QOL), yet few studies have
explored factors associated with improving health-related
QOL (HRQOL) in this population. We thus explored the
relationship between physical activity (PA) and HRQOL among
survivors of childhood cancer. METHODS: A total of 215
survivors of childhood lymphoma, leukemia, and central
nervous system cancers completed mailed surveys that
elicited information regarding leisure-time PA (LTPA)
measured in metabolic equivalents, HRQOL, and diagnostic and
demographic factors. Correlations and adjusted regression
models were used to explore the relationship between LTPA
and HRQOL. RESULTS: In the total sample, modest, yet
significant linear associations were observed between LTPA
and overall HRQOL (beta=0.17, p<0.01), as well as each of
the respective subscales (beta=0.11-0.23 and p's<0.05 to
<0.001). Among adolescent survivors of childhood cancer,
LTPA was significantly associated with overall HRQOL
(beta=0.27), cancer worry (beta=0.36), cognitive function
(beta=0.32), body appearance (beta=0.29), and social
function (beta=0.27) (all p's<0.05). Among adult survivors
of childhood cancer, LTPA was only significantly associated
with physical function (beta=0.28, p<0.001). CONCLUSIONS:
Significant associations exist between LTPA and HRQOL;
however, the association was stronger and observed in more
domains for adolescent survivors of childhood cancer. More
research is needed to determine the antecedents and
consequences of PA in this population.},
Doi = {10.1002/pon.1654},
Key = {fds271084}
}
@article{fds271082,
Author = {Conklin, HM and Helton, S and Ashford, J and Mulhern, RK and Reddick,
WE and Brown, R and Bonner, M and Jasper, BW and Wu, S and Xiong, X and Khan,
RB},
Title = {Predicting methylphenidate response in long-term survivors
of childhood cancer: a randomized, double-blind,
placebo-controlled, crossover trial.},
Journal = {J Pediatr Psychol},
Volume = {35},
Number = {2},
Pages = {144-155},
Year = {2010},
Month = {March},
ISSN = {0146-8693},
url = {http://dx.doi.org/10.1093/jpepsy/jsp044},
Abstract = {OBJECTIVE: To investigate the methylphenidate (MPH) response
rate among childhood survivors of acute lymphoblastic
leukemia (ALL) and brain tumors (BTs) and to identify
predictors of positive MPH response. METHODS: Cancer
survivors (N = 106; BT = 51 and ALL = 55) identified as
having attention deficits and learning problems participated
in a 3-week, double-blind, crossover trial consisting of
placebo, low-dose MPH (0.3 mg/kg), and moderate-dose MPH
(0.6 mg/kg). Weekly teacher and parent reports on the
Conners' Rating Scales were gathered. RESULTS: Following
moderate MPH dose, 45.28% of the sample was classified as
responders. Findings revealed that more problems endorsed
prior to the medication trial on parent and teacher ratings
were predictive of positive medication response (p < .05).
CONCLUSIONS: MPH significantly reduces attention problems in
a subset of childhood cancer survivors. Parent and teacher
ratings may assist in identifying children most likely to
respond to MPH so prescribing may be optimally
targeted.},
Doi = {10.1093/jpepsy/jsp044},
Key = {fds271082}
}
@article{fds271081,
Author = {Bonner, MJ},
Title = {Health related quality of life in sickle cell disease: just
scratching the surface.},
Journal = {Pediatr Blood Cancer},
Volume = {54},
Number = {1},
Pages = {1-2},
Year = {2010},
Month = {January},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19785024},
Doi = {10.1002/pbc.22301},
Key = {fds271081}
}
@article{fds271083,
Author = {Hardy, KK and Willard, VW and Watral, MA and Bonner,
MJ},
Title = {Perceived social competency in children with brain tumors:
comparison between children on and off therapy.},
Journal = {J Pediatr Oncol Nurs},
Volume = {27},
Number = {3},
Pages = {156-163},
Year = {2010},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20147514},
Abstract = {Children with brain tumors are at risk for a number of
cognitive, academic, and social difficulties as a
consequence of their illness and its treatment. Of these,
the least is known about social functioning, particularly
over the course of the illness. Thirty children with brain
tumors were evaluated using neurocognitive and psychological
measures, including a measure of perceived competency.
Results indicated that off-therapy brain tumor patients
reported more concerns about their social competence than
both a normative sample and children on treatment. Findings
highlight the need for more research aimed at helping
survivors cope with long-term stressors associated with
their illness.},
Doi = {10.1177/1043454209357918},
Key = {fds271083}
}
@article{fds271078,
Author = {Willard, VW and Hardy, KK and Bonner, MJ},
Title = {Gender differences in facial expression recognition in
survivors of pediatric brain tumors.},
Journal = {Psychooncology},
Volume = {18},
Number = {8},
Pages = {893-897},
Year = {2009},
Month = {August},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19061181},
Abstract = {OBJECTIVE: To examine the relation between gender, history
of cranial radiation therapy (CRT) and facial expression
recognition (FER) skill in survivors of pediatric brain
tumors. METHODS: Fifty-three survivors (27 females)
completed a measure of FER and an intelligence test.
RESULTS: There was a significant interaction between gender
and CRT on ability to interpret low-intensity facial
expressions, such that females who had not had CRT made
fewer errors than either females who had CRT or males.
CONCLUSION: A history of CRT has a notable effect on FER
skill in females: girls who received CRT performed
significantly more poorly than girls who did
not.},
Doi = {10.1002/pon.1502},
Key = {fds271078}
}
@article{fds271077,
Author = {Hutchinson, KC and Willard, VW and Hardy, KK and Bonner,
MJ},
Title = {Adjustment of caregivers of pediatric patients with brain
tumors: a cross-sectional analysis.},
Journal = {Psychooncology},
Volume = {18},
Number = {5},
Pages = {515-523},
Year = {2009},
Month = {May},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18756585},
Abstract = {OBJECTIVE: The purpose of the study was to compare the
psychological adjustment of caregivers of children with
brain tumors who are on-treatment with caregivers of
children who are off-treatment. METHODS: Data were collected
from 90 participants: 47 (52.2%) caregivers of children
undergoing active treatment (on-treatment) and 43 (47.8%)
caregivers of children off-treatment on measures of global
psychological distress and illness and caregiving related
distress. RESULTS: Results revealed that the two groups
differed significantly in their reported symptoms of general
psychological distress, with the off-treatment caregivers
reporting significantly lower levels of general distress.
However, off-treatment caregivers continued to experience
elevated levels of uncertainty and caregiving burden related
to their child's illness. CONCLUSIONS: There is significant
evidence suggesting that the burden of caring for a child
with a brain tumor is ongoing, continuing well into the
off-treatment period. These results also suggest that the
psychosocial functioning of these caregivers is best
assessed using measures designed specifically to evaluate
illness-related psychosocial functioning (e.g. the Parent
Experience of Child Illness, Impact on Family
Scale).},
Doi = {10.1002/pon.1421},
Key = {fds271077}
}
@article{fds271080,
Author = {Thornburg, CD and Dixon, N and Burgett, S and Mortier, NA and Schultz,
WH and Zimmerman, SA and Bonner, M and Hardy, KK and Calatroni, A and Ware,
RE},
Title = {A pilot study of hydroxyurea to prevent chronic organ damage
in young children with sickle cell anemia.},
Journal = {Pediatr Blood Cancer},
Volume = {52},
Number = {5},
Pages = {609-615},
Year = {2009},
Month = {May},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19061213},
Abstract = {BACKGROUND: Hydroxyurea improves laboratory parameters and
prevents acute clinical complications of sickle cell anemia
(SCA) in children and adults, but its effects on organ
function remain incompletely defined. METHODS: To assess the
safety and efficacy of hydroxyurea in young children with
SCA and to prospectively assess kidney and brain function,
14 young children (mean age 35 months) received hydroxyurea
at a mean maximum tolerated dose (MTD) of 28 mg/kg/day.
RESULTS: After a mean of 25 months, expected laboratory
effects included significant increases in hemoglobin, MCV
and %HbF along with significant decreases in reticulocytes,
absolute neutrophil count, and bilirubin. There was no
significant increase in glomerular filtration rate by DTPA
clearance or Schwartz estimate. Mean transcranial Doppler
(TCD) velocity changes were -25.6 cm/sec (P < 0.01) and
-26.8 cm/sec (P < 0.05) in the right and left MCA vessels,
respectively. At study exit, no child had conditional or
abnormal TCD values, and none developed brain ischemic
lesions or vasculopathy progression by MRI/MRA. Growth and
neurocognitive scores were preserved and Impact-on-Family
scores improved. CONCLUSIONS: These pilot data indicate
hydroxyurea at MTD is well-tolerated by both children and
families, and may prevent chronic organ damage in young
children with SCA.},
Doi = {10.1002/pbc.21738},
Key = {fds271080}
}
@article{fds271076,
Author = {Bonner, MJ and Hardy, KK and Willard, VW and Gururangan,
S},
Title = {Additional evidence of a nonverbal learning disability in
survivors of pediatric brain tumors},
Journal = {Children's Health Care},
Volume = {38},
Number = {1},
Pages = {49-63},
Publisher = {Informa UK Limited},
Year = {2009},
Month = {January},
ISSN = {0273-9615},
url = {http://dx.doi.org/10.1080/02739610802615849},
Abstract = {The purpose of the study was to further examine the utility
of the nonverbal learning disability (NLD) model for
characterizing deficits in pediatric brain tumor survivors.
Data from measures of cognitive, academic, and social
functioning were gathered from 101 survivors. Results
revealed a pattern consistent with expectations based on the
NLD model including stronger verbal than nonverbal
intellectual and memory functioning, stronger reading than
math skills, and weaknesses in visual-motor integration and
processing speed. Moreover, findings support evidence of
social problems in this sample. Further testing of the NLD
model is needed to provide a comprehensive roadmap for
assessment and intervention in pediatric cancer survivors.
Copyright © Taylor & Francis Group, LLC.},
Doi = {10.1080/02739610802615849},
Key = {fds271076}
}
@article{fds271079,
Author = {Willard, VW and Bonner, MJ and Guill, AB},
Title = {Healthy lifestyle choices after cancer treatment.},
Journal = {Cancer Treat Res},
Volume = {150},
Pages = {343-352},
Year = {2009},
ISSN = {0927-3042},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19834679},
Doi = {10.1007/b109924_22},
Key = {fds271079}
}
@article{fds271075,
Author = {Hardy, KK and Bonner, MJ and Willard, VW and Watral, MA and Gururangan,
S},
Title = {Hydrocephalus as a possible additional contributor to
cognitive outcome in survivors of pediatric
medulloblastoma.},
Journal = {Psychooncology},
Volume = {17},
Number = {11},
Pages = {1157-1161},
Year = {2008},
Month = {November},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18636431},
Abstract = {OBJECTIVES: The purpose of the study was to assess the
relationship between shunted hydrocephalus and intellectual,
memory and academic functioning in a group of survivors of
pediatric medulloblastoma. METHODS: Data from measures of
cognitive, memory, academic and visual-motor functioning
were gathered retrospectively from 35 survivors. Of these
survivors, 10 (28.6%) required ventriculoperitoneal-shunt
placement for hydrocephalus posttumor resection. RESULTS:
Results revealed that participants with shunted
hydrocephalus demonstrated significantly lower IQs, lower
nonverbal intellectual functioning, lower academic skills in
writing and math, and impairments in visual-motor abilities
when compared with those without shunt. CONCLUSIONS: These
results highlight the need to explore other variables--in
addition to radiation and chemotherapy--as risk factors for
neurocognitive impairments in survivors. Furthermore,
identification of physiological substrates underlying these
deficits is needed.},
Doi = {10.1002/pon.1349},
Key = {fds271075}
}
@article{fds271099,
Author = {Bonner, MJ and Hardy, KK and Willard, VW and Hutchinson, KC and Guill,
AB},
Title = {Further validation of the parent experience of child illness
scale},
Journal = {Children's Health Care},
Volume = {37},
Number = {2},
Pages = {145-157},
Publisher = {Informa UK Limited},
Year = {2008},
Month = {April},
ISSN = {0273-9615},
url = {http://dx.doi.org/10.1080/02739610802006569},
Abstract = {The objective of this research is to provide further
validation of the Parent Experience of Child Illness (PECI)
scale. One hundred twenty-five caregivers of patients (age <
1-17 years) diagnosed with cancer returned questionnaire
data at Time 1, and 75 caregivers at Time 2. Findings
provide support for the psychometric properties of the PECI,
including good test-retest reliability and convergent and
discriminant validity. The PECI appears to be a valid
assessment tool for evaluation of the distress and perceived
resources of caregivers of pediatric cancer patients.
Continued evaluation is needed with other chronic illness
groups. Copyright © Taylor & Francis Group,
LLC.},
Doi = {10.1080/02739610802006569},
Key = {fds271099}
}
@article{fds271109,
Author = {Hardy, KK and Bonner, MJ and Masi, R and Hutchinson, KC and Willard, VW and Rosoff, PM},
Title = {Psychosocial functioning in parents of adult survivors of
childhood cancer.},
Journal = {J Pediatr Hematol Oncol},
Volume = {30},
Number = {2},
Pages = {153-159},
Year = {2008},
Month = {February},
ISSN = {1077-4114},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18376269},
Abstract = {BACKGROUND: Although significant progress has been made in
identifying long-term sequelae for adult survivors of
childhood cancer, comparatively little attention has been
paid to the functioning of their parents. In a previous
study, we observed that a majority of adult survivors are
accompanied to clinic visits by at least 1 parent,
suggesting ongoing concern for their children's health. In
the current study, we explore psychologic stressors that
characterize this population and might account for this
finding. PROCEDURE: Responses to measures of psychosocial
functioning (ie, Brief Symptom Inventory, Impact on Family
Scale, Impact of Events Scale, Parent Experience of Child
Illness Scale) were compared between 27 parents of adult
survivors (mean age=25.6 y) of pediatric cancer and 28
parents of current pediatric cancer patients (mean age=10.2
y) on, or within 1 year of, active treatment. RESULTS:
Compared with parents of pediatric cancer patients on
treatment, parents of adult survivors demonstrated few
significant differences in overall psychologic functioning,
posttraumatic stress symptoms, and adjustment to the disease
experience. Indeed, the 2 groups differed only in their
report of objective and family burden (eg, financial cost,
time off from work, less time with family members), and in
their levels of anger associated with the illness
experience. CONCLUSIONS: Results suggest that parents who
continue to accompany their adult child to clinic may remain
psychologically vulnerable many years after the end of
treatment, and that the impact of having a child with a
life-threatening illness may not diminish even years into
the child's survivorship.},
Doi = {10.1097/MPH.0b013e31815814d9},
Key = {fds271109}
}
@article{fds271100,
Author = {Arroyave, WD and Clipp, EC and Miller, PE and Jones, LW and Ward, DS and Bonner, MJ and Rosoff, PM and Snyder, DC and Demark-Wahnefried,
W},
Title = {Childhood cancer survivors' perceived barriers to improving
exercise and dietary behaviors.},
Journal = {Oncol Nurs Forum},
Volume = {35},
Number = {1},
Pages = {121-130},
Year = {2008},
Month = {January},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18192161},
Abstract = {PURPOSE/OBJECTIVES: To determine childhood cancer survivors'
barriers to increasing exercise and consuming less fat and
more fruits and vegetables, whole grains, and calcium-rich
foods. DESIGN: Mailed survey. SETTING: Cases from a
comprehensive cancer center. SAMPLE: Convenience sample of
144 childhood cancer survivors aged 13-35 years identified
through previous research. Surveys were returned by 118
participants (82% response rate). METHODS: Descriptive
statistics with chi-square tests were performed between
subgroups defined by age (< 18 years and < or = 18 years)
and diagnosis (leukemia, lymphoma, and central nervous
system cancers). MAIN RESEARCH VARIABLES: Barriers to
exercise, consuming less fat, and eating more fruits and
vegetables, whole grains, and calcium-rich foods. FINDINGS:
Proportionately more childhood cancer survivors reported
barriers to exercise and following a low-fat diet than to
consuming more fruits and vegetables, whole grains, and
calcium-rich foods. Primary barriers to exercise included
being too tired (57%), being too busy (53%), and not
belonging to a gym (48%), whereas barriers for restricting
high-fat foods were commercials that make high-fat foods
look so appealing (58%) and having friends who eat a lot of
high-fat foods (50%). Difficulty associated with ordering
healthy foods when dining out also was a leading barrier to
following a low-fat diet (50%), as well as eating more whole
grains (31%), fruits and vegetables (30%), and calcium-rich
foods (15%). CONCLUSIONS: Childhood cancer survivors report
several barriers to exercise and consuming a low-fat diet
with more fruits and vegetables, whole grains, and
calcium-rich foods. IMPLICATIONS FOR NURSING: This study's
findings may be helpful to nurses, health educators, and
allied health professionals in developing effective
interventions that promote healthful lifestyle change among
childhood cancer survivors.},
Doi = {10.1188/08.ONF.121-130},
Key = {fds271100}
}
@article{fds271096,
Author = {Bonner, MJ and Hardy, KK and Willard, VW and Anthony, KK and Hood, M and Gururangan, S},
Title = {Social functioning and facial expression recognition in
survivors of pediatric brain tumors.},
Journal = {J Pediatr Psychol},
Volume = {33},
Number = {10},
Pages = {1142-1152},
Year = {2008},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18390896},
Abstract = {OBJECTIVE: To assess social functioning and facial
expression recognition skill in survivors of pediatric brain
tumors (BT) as compared to children with juvenile rheumatoid
arthritis (JRA). METHODS: The social functioning of 51
survivors of BT and 31 children with JRA was assessed using
a facial expression recognition task, questionnaire ratings
of social functioning, and an IQ screener. RESULTS: After
controlling for estimated IQ, survivors of BT made
significantly more errors interpreting adult facial
expressions as compared to children with JRA. Additionally,
history of therapy and diagnosis age predicted performance
on the child portion of the facial recognition task.
Finally, survivors of BT demonstrated significantly impaired
social functioning across multiple measures when compared to
children with JRA. CONCLUSIONS: Survivors of pediatric BT
showed significant deficits in social functioning as
compared to an illness comparison group. Errors in facial
expression recognition represent another method for
evaluating deficits that contribute to social
outcomes.},
Doi = {10.1093/jpepsy/jsn035},
Key = {fds271096}
}
@article{fds271095,
Author = {Edwards, CL and Raynor, RD and Feliu, M and McDougald, C and Johnson, S and Schmechel, D and Wood, M and Bennett, GG and Saurona, P and Bonner, M and Wellington, C and DeCastro, LM and Whitworth, E and Abrams, M and Logue,
P and Edwards, L and Martinez, S and Whitfield, KE},
Title = {Neuropsychological assessment, neuroimaging, and
neuropsychiatric evaluation in pediatric and adult patients
with sickle cell disease (SCD).},
Journal = {Neuropsychiatr Dis Treat},
Volume = {3},
Number = {6},
Pages = {705-709},
Year = {2007},
Month = {December},
ISSN = {1176-6328},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19300604},
Abstract = {Traditionally, neuropsychological deficits due to Sickle
Cell Disease (SCD) have been understudied in adults. We have
begun to suspect, however, that symptomatic and asymptomatic
Cerebrovascular Events (CVE) may account for an alarming
number of deficits in this population. In the current brief
review, we critically evaluated the pediatric and adult
literatures on the neurocognitive effects of SCD. We
highlighted the studies that have been published on this
topic and posit that early detection of CVE via
neurocognitive testing, neuropsychiatric evaluations, and
neuroimaging may significantly reduce adult cognitive and
functional morbidities.},
Doi = {10.2147/ndt.s518},
Key = {fds271095}
}
@article{fds271101,
Author = {Conklin, HM and Khan, RB and Reddick, WE and Helton, S and Brown, R and Howard, SC and Bonner, M and Christensen, R and Wu, S and Xiong, X and Mulhern, RK},
Title = {Acute neurocognitive response to methylphenidate among
survivors of childhood cancer: a randomized, double-blind,
cross-over trial.},
Journal = {J Pediatr Psychol},
Volume = {32},
Number = {9},
Pages = {1127-1139},
Year = {2007},
Month = {October},
ISSN = {0146-8693},
url = {http://dx.doi.org/10.1093/jpepsy/jsm045},
Abstract = {OBJECTIVE: To investigate the acute efficacy and adverse
side effects of methylphenidate (MPH) among survivors of
childhood cancer [acute lymphoblastic leukemia (ALL) or
brain tumor (BT)] with learning impairments. METHODS:
Participants (N = 122) completed a two-day, in-clinic,
double-blind, cross-over trial during which they received
MPH (0.60 mg/kg of body weight) and placebo that were
randomized in administration order across participants.
Performance was evaluated using measures of attention,
memory, and academic achievement. RESULTS: A significant MPH
versus placebo effect was revealed on a measure of
attention, cognitive flexibility, and processing speed
(Stroop Word-Color Association Test). Male gender, older age
at treatment, and higher intelligence were predictive of
better medication response. No significant differences were
found for number or severity of adverse side effects as a
function of active medication. CONCLUSIONS: MPH shows some
neurocognitive benefit and is well tolerated by the majority
of children surviving ALL and BT.},
Doi = {10.1093/jpepsy/jsm045},
Key = {fds271101}
}
@article{fds271107,
Author = {Bonner, MJ and Hardy, KK and Willard, VW and Hutchinson,
KC},
Title = {Brief report: psychosocial functioning of fathers as primary
caregivers of pediatric oncology patients.},
Journal = {J Pediatr Psychol},
Volume = {32},
Number = {7},
Pages = {851-856},
Year = {2007},
Month = {August},
ISSN = {0146-8693},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17426044},
Abstract = {OBJECTIVE: To evaluate the psychosocial functioning of
fathers as primary caregivers of pediatric oncology
patients. METHODS: Fathers who identified themselves as the
primary medical caregivers were given a packet of
questionnaires, including the Brief Symptom Inventory (BSI),
the Impact of Event Scale (IES), the Impact on Family Scale
(IFS), the Caregiver Strain Questionnaire (CGSQ), and the
Parent Experience of Child Illness (PECI) scale, to complete
and return by mail. The 23 fathers who returned the
questionnaire packets were compared with 23 mothers who were
matched on demographic variables. RESULTS: There were no
differences between groups on self-report measures of
distress or illness-related parenting stress. Descriptively,
however, the majority of parents were above normative means
on measures of psychological distress with a significantly
greater proportion of fathers endorsing elevated levels of
depression on the BSI. CONCLUSION: Including fathers in
pediatric psychosocial research is important and represents
a growing trend in psycho-oncology.},
Doi = {10.1093/jpepsy/jsm011},
Key = {fds271107}
}
@article{fds271098,
Author = {Edwards, and CL, and Raynor, and RD, and Feliu, and M, and McDougald, and C, and Johnson, and Schmechel, and D, and Wood, and Bennett, and GG, and Saurona, and P, and Bonner, and al, MJE},
Title = {Neuropsychological assessment, neuroimaging, and early
neurocognitive evaluation in pediatric and adult patients
with sickle cell disease},
Journal = {Neuropsychiatry Disease and Treatment},
Volume = {3},
Pages = {1-5},
Year = {2007},
Key = {fds271098}
}
@article{fds304914,
Author = {Bonner, MJ and Hardy, KK and Guill, AB and McLaughlin, C and Schweitzer,
H and Carter, K},
Title = {Development and validation of the parent experience of child
illness.},
Journal = {J Pediatr Psychol},
Volume = {31},
Number = {3},
Pages = {310-321},
Year = {2006},
Month = {April},
ISSN = {0146-8693},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15917492},
Abstract = {OBJECTIVE: To develop a measure of parent adjustment related
to caring for a child with a chronic illness and to evaluate
the reliability and validity of the measure with a group of
parents of children with brain tumors. METHODS: One-hundred
forty-nine parents of patients (age <1-17 years) diagnosed
with a brain tumor were assessed using the 25-item
self-report Parent Experience of Child Illness (PECI).
Internal consistency, construct validity, and factor
structure were assessed. RESULTS: Exploratory factor
analysis yielded four theoretically coherent factors
including: Guilt and Worry, Emotional Resources, Unresolved
Sorrow and Anger, and Long-term Uncertainty. Internal
reliability for the PECI scales ranged from .72 to .89,
suggesting acceptable reliability. As evidence of construct
validity, the PECI scales show significant, positive
correlations with scales from established measures of parent
adjustment. CONCLUSION: The PECI augments the current
literature by providing a brief measure of parents'
subjective distress and perceived Emotional Resources,
domains that are critical but understudied in children with
chronic illness and their caregivers.},
Doi = {10.1093/jpepsy/jsj034},
Key = {fds304914}
}
@article{fds304915,
Author = {Helton, SC and Corwyn, RF and Bonner, MJ and Brown, RT and Mulhern,
RK},
Title = {Factor analysis and validity of the Conners Parent and
Teacher Rating Scales in childhood cancer
survivors.},
Journal = {J Pediatr Psychol},
Volume = {31},
Number = {2},
Pages = {200-208},
Year = {2006},
Month = {March},
ISSN = {0146-8693},
url = {http://dx.doi.org/10.1093/jpepsy/jsj010},
Abstract = {OBJECTIVE: To examine the factor structure of the Conners
Parent Rating Scale-Revised: Short Form (CPRS-R:S) and the
Conners Teacher Rating Scale-Revised: Short Form (CTRS-R:S)
in children who are long-term survivors of acute lymphocytic
leukemia (ALL) or brain tumors (BT)and who have received
central nervous system directed treatment. METHOD: Parents
and teachers of 150 long-term survivors completed the
CPRS-R:S or CTRS-R:S as part of a screening battery. The
data were submitted to a maximum likelihood confirmatory
factor analysis to test the construct validity of the scales
and the forms were compared. The CPRS-R:S was also compared
to selected subscales of the Achenbach Child Behavior
Checklist (CBCL) for further validation. RESULTS: The
analyses demonstrated an adequate fit of the original
three-factor structure of the CTRS-R:S [oppositional,
cognitive problems/inattention, hyperactivity]. The analyses
of the CPRS-R:S suggested a less adequate fit of the
original three-factor structure but principal components
factor analysis yielded a three-factor solution with factors
similar to those of Conners' original factor structure.
Significant correlations were found between the CPRS-R:S and
the selected subscales of the CBCL. CONCLUSIONS: These
findings support the similar construct validity of the
original CTRS-R:S and CPRS-R:S. Although significantly
correlated, the CPRS-R:S and CTRS-R:S are not
interchangeable in the assessment of survivors of childhood
cancer.},
Doi = {10.1093/jpepsy/jsj010},
Key = {fds304915}
}
@article{fds271104,
Author = {Reddick, WE and Shan, ZY and Glass, JO and Helton, S and Xiong, X and Wu,
S and Bonner, MJ and Howard, SC and Christensen, R and Khan, RB and Pui,
C-H and Mulhern, RK},
Title = {Smaller white-matter volumes are associated with larger
deficits in attention and learning among long-term survivors
of acute lymphoblastic leukemia.},
Journal = {Cancer},
Volume = {106},
Number = {4},
Pages = {941-949},
Year = {2006},
Month = {February},
url = {http://dx.doi.org/10.1002/cncr.21679},
Abstract = {BACKGROUND: The primary objective of this study was to test
the hypothesis that survivors of childhood acute
lymphoblastic leukemia (ALL) have deficits in neurocognitive
performance, and smaller white-matter volumes are associated
with these deficits. METHODS: The patients studied included
112 ALL survivors (84 patients who had received chemotherapy
only, 28 patients who had received chemotherapy and
irradiation; 63 males, 49 females; mean age +/- standard
deviation, 4.1 yrs +/- 2.6 yrs at diagnosis; mean +/-
standard deviation yrs since diagnosis, 6.0 +/- 3.5 yrs),
and 33 healthy siblings who participated as a control group.
Neurocognitive tests of attention, intelligence, and
academic achievement were performed; and magnetic resonance
images were obtained and subsequently were segmented to
yield tissue volume measurements. Comparisons of
neurocognitive measures and tissue volumes between groups
were performed, and the correlations between volumes and
neurocognitive performance measures were assessed. RESULTS:
Most performance measures demonstrated statistically
significant differences from the normative test scores, but
only attention measures exceeded 1.0 standard deviation from
normal. Patients who had received chemotherapy alone had
significantly larger volumes of white matter than patients
who had received treatment that also included cranial
irradiation, but their volumes remained significantly
smaller than the volumes in the control group. Smaller
white-matter volumes were associated significantly with
larger deficits in attention, intelligence, and academic
achievement. CONCLUSIONS: Survivors of childhood ALL had
significant deficits in attention and smaller white-matter
volumes that were associated directly with impaired
neurocognitive performance. Cranial irradiation exacerbated
these deficits.},
Doi = {10.1002/cncr.21679},
Key = {fds271104}
}
@article{fds271060,
Author = {Bonner, MJ and Hardy, KK and Willard, VW and Guill,
AB},
Title = {Association between the Parent Experience of Childhood
Illness (PECI) scale and clinician ratings of functioning
among parents of children with cancer},
Journal = {PSYCHO-ONCOLOGY},
Volume = {15},
Number = {1},
Pages = {S41-S42},
Publisher = {JOHN WILEY & SONS LTD},
Year = {2006},
Month = {February},
ISSN = {1057-9249},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000235659000075&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds271060}
}
@article{fds271102,
Author = {Bonner, MJ and Hardy, KK and Guill, AB and McLaughlin, C and Schweitzer,
H and Carter, K},
Title = {Development and validation of the ParentExperience of
Illness (PECI) Questionnaire},
Journal = {Journal of Pediatric Psychology},
Volume = {31},
Number = {3},
Pages = {310-321},
Year = {2006},
ISSN = {0146-8693},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15917492},
Abstract = {OBJECTIVE: To develop a measure of parent adjustment related
to caring for a child with a chronic illness and to evaluate
the reliability and validity of the measure with a group of
parents of children with brain tumors. METHODS: One-hundred
forty-nine parents of patients (age <1-17 years) diagnosed
with a brain tumor were assessed using the 25-item
self-report Parent Experience of Child Illness (PECI).
Internal consistency, construct validity, and factor
structure were assessed. RESULTS: Exploratory factor
analysis yielded four theoretically coherent factors
including: Guilt and Worry, Emotional Resources, Unresolved
Sorrow and Anger, and Long-term Uncertainty. Internal
reliability for the PECI scales ranged from .72 to .89,
suggesting acceptable reliability. As evidence of construct
validity, the PECI scales show significant, positive
correlations with scales from established measures of parent
adjustment. CONCLUSION: The PECI augments the current
literature by providing a brief measure of parents'
subjective distress and perceived Emotional Resources,
domains that are critical but understudied in children with
chronic illness and their caregivers.},
Doi = {10.1093/jpepsy/jsj034},
Key = {fds271102}
}
@article{fds271103,
Author = {Helton, S and Corwyn, RF and Bonner, MJ and Brown, RT and Mulhern,
RK},
Title = {Factor analysis and teacher rating scales in childhood
cancer survivors},
Journal = {Journal of Pediatric Psychology},
Volume = {31},
Number = {2},
Pages = {200-208},
Year = {2006},
ISSN = {0146-8693},
url = {http://dx.doi.org/10.1093/jpepsy/jsj010},
Abstract = {Objective: To examine the factor structure of the Conners
Parent Rating Scale - Revised: Short Form (CPRS-R:S) and the
Conners Teacher Rating Scale - Revised: Short Form
(CTRS-R:S) in children who are long-term survivors of acute
lymphocytic leukemia (ALL) or brain tumors (BT)and who have
received central nervous system directed treatment. Method:
Parents and teachers of 150 long-term survivors completed
the CPRS-R:S or CTRS-R:S as part of a screening battery. The
data were submitted to a maximum likelihood confirmatory
factor analysis to test the construct validity of the scales
and the forms were compared. The CPRS-R:S was also compared
to selected subscales of the Achenbach Child Behavior
Checklist (CBCL) for further validation. Results: The
analyses demonstrated an adequate fit of the original
three-factor structure of the CTRS-R:S [oppositional,
cognitive problems/inattention, hyperactivity]. The analyses
of the CPRS-R:S suggested a less adequate fit of the
original three-factor structure but principal components
factor analysis yielded a three-factor solution with factors
similar to those of Conners' original factor structure.
Significant correlations were found between the CPRS-R:S and
the selected subscales of the CBCL. Conclusions: These
findings support the similar construct validity of the
original CTRS-R:S and CPRS-R:S. Although significantly
correlated, the CPRS-R:S and CTRS-R:S are not
interchangeable in the assessment of survivors of childhood
cancer. © The Author 2005. Published by Oxford University
Press on behalf of the Society of Pediatric Psychology. All
rights reserved.},
Doi = {10.1093/jpepsy/jsj010},
Key = {fds271103}
}
@article{fds271071,
Author = {Demark-Wahnefried, W and Werner, C and Clipp, EC and Guill, AB and Bonner, M and Jones, LW and Rosoff, PM},
Title = {Survivors of childhood cancer and their guardians.},
Journal = {Cancer},
Volume = {103},
Number = {10},
Pages = {2171-2180},
Year = {2005},
Month = {May},
ISSN = {0008-543X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15812823},
Abstract = {BACKGROUND: Survivors of childhood cancer are at increased
risk for osteoporosis, cardiovascular disease, and second
malignancies-conditions for which modifiable risk factors
are recognized and lifestyle interventions have shown
benefit. Although some data regarding health behaviors of
this population exist, receptivity to health promotion is
largely unknown. METHODS: A survey was mailed to 380
survivors (age range, 11-33 years) of childhood leukemia,
lymphoma, or central nervous system carcinomas (and
guardians of survivors < 18 years old) to elicit data on
exercise, dietary intake of calcium, fat, and fruits and
vegetables, smoking status, readiness to pursue lifestyle
change, quality of life, and interest in various health
interventions. RESULTS: Responses from 209 survivors (a 55%
response rate) suggested that most did not meet guidelines
for fruit and vegetable consumption (79%), calcium intake
(68%), or exercise (52%), 42% were overweight/obese, and 84%
consumed > 30% of calories from fat. Older (> 18 years)
compared with younger (< 18 years) survivors were more
likely to smoke (17% vs. 1%), to be obese (21.6% vs. 14.6%),
and to have suboptimal calcium intakes (75.6% vs. 57.6%). No
differences in lifestyle behaviors were observed between
cancer groups. Compared with interventions aimed at weight
control, improving self-esteem, or smoking cessation, the
highest levels of interest were found consistently for
interventions aimed at getting in shape and eating healthy.
Survivors preferred mailed interventions to those delivered
in-person, by telephone counselors, or via computers.
CONCLUSIONS: Survivors of childhood cancer practiced several
suboptimal health behaviors. Health promotion interventions
aimed at areas of interest and delivered through acceptable
channels have the potential to improve long-term health and
function of this vulnerable population.},
Doi = {10.1002/cncr.21009},
Key = {fds271071}
}
@article{fds271072,
Author = {Rosoff, PM and Werner, C and Clipp, EC and Guill, AB and Bonner, M and Demark-Wahnefried, W},
Title = {Response rates to a mailed survey targeting childhood cancer
survivors: a comparison of conditional versus unconditional
incentives.},
Journal = {Cancer Epidemiol Biomarkers Prev},
Volume = {14},
Number = {5},
Pages = {1330-1332},
Year = {2005},
Month = {May},
ISSN = {1055-9965},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15894697},
Abstract = {OBJECTIVE: Mailed surveys are widely used to collect
epidemiologic and health service data. Given that
nonresponse can threaten the validity of surveys, modest
incentives are often used to increase response rates. A
study was undertaken among childhood cancer survivors and
their parents to determine if response rate to a mailed
survey differed with provision of immediate versus delayed
incentives. DESIGN: A self-administered survey designed to
ascertain health behaviors was mailed to 397 childhood
cancer survivors (and their parents if the survivor was <18
years of age). Subjects were randomized into two groups
based on gender, age, race, and cancer type. One group
received a 10 US dollars incentive with their blank survey
(unconditional incentive), whereas the other group received
the incentive upon receipt of their completed survey
(conditional incentive). If children were minors, both the
parent and the child received incentives. RESULTS: No
significant differences in response rates were observed with
respect to gender, age, race, or cancer type. However,
significant differences in response rates were observed
between incentive groups, with unconditional incentives
yielding significantly higher response rates than
conditional incentives for child survivors who were > or =18
years (64.4% versus 49.0%), as well as younger child
survivors (62.5% versus 43.6%) and their parents (64.8%
versus 41.5%; all P < 0.05). CONCLUSIONS: The provision of
an immediate incentive generated significantly higher
response rates to this mailed health survey among childhood
cancer survivors and their parents. Given that survey
studies are commonly conducted across various pediatric
populations, these findings may help inform the design of
future pediatric survey research.},
Doi = {10.1158/1055-9965.EPI-04-0716},
Key = {fds271072}
}
@article{fds271105,
Author = {Demark Wahnefried and W and Werner, C and Clipp, E and Guill, AB and Bonner, MJ and Rosoff, PM},
Title = {Childhood cander survivors and their guardians: Current
health behaviors and receptivity to health promotion
programs},
Journal = {Cancer},
Volume = {103},
Year = {2005},
Key = {fds271105}
}
@article{fds271106,
Author = {Rosoff, PM and Werner, C and Clipp, E and Guill, AB and Bonner, MJ and Demark Wahnefried and W},
Title = {Response rates to a mailed survey targeting childhood cancer
survivors},
Journal = {Cancer Epidemiology, Biomarkers and Prevention},
Volume = {14},
Pages = {1330-1332},
Year = {2005},
Key = {fds271106}
}
@article{fds271108,
Author = {Mulhern, RK and Khan, RB and Kaplan, S and Helton, S and Christensen, R and Bonner, M and Brown, R and Xiong, X and Wu, S and Gururangan, S and Reddick, WE},
Title = {Short-term efficacy of methylphenidate: a randomized,
double-blind, placebo-controlled trial among survivors of
childhood cancer.},
Journal = {Journal of clinical oncology : official journal of the
American Society of Clinical Oncology},
Volume = {22},
Number = {23},
Pages = {4795-4803},
Year = {2004},
Month = {December},
ISSN = {0732-183X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15570081},
Abstract = {PURPOSE: Children surviving acute lymphoblastic leukemia
(ALL) and malignant brain tumors (BTs) have a higher
incidence of attention and learning problems in school than
do their healthy peers. The present study tests the
hypothesis that the psychostimulant methylphenidate (MPH)
improves cognitive and social functioning among these
patients. PATIENTS AND METHODS: We report on 83 long-term
survivors of ALL and BT identified as having attentional
deficits on behavioral testing and parent or teacher report,
and problems with academic achievement. The 47 male and 36
female patients ranged from 0.6 to 14.3 years (median, 5.4
years) of age at diagnosis and 6.7 to 17.9 years (median,
11.9 years) of age at participation. The patients (40 ALL,
43 BT) participated in a randomized, double-blind, 3-week
home cross-over trial of placebo (bid), low-dose MPH (0.3
mg/kg; maximum dose, 10 mg bid), and moderate-dose MPH (0.6
mg/kg; maximum dose, 20 mg bid). The primary end points were
weekly teacher and parent reports on the Conners' Rating
Scales and Social Skills Rating System. RESULTS: Compared to
placebo, significant improvement with MPH was reported by
teachers and parents on the Conners' Rating Scales and by
teachers on the Social Skills Rating System. However, no
consistent advantage of moderate dose over low dose was
observed. Of those participating, 66 (79.5%) of the 83
patients continued on best clinical management. CONCLUSION:
Treatment with MPH can at least temporarily reduce some
attentional and social deficits among survivors of childhood
ALL and BT. Long-term follow-up will reveal those subsets of
patients who are more likely to benefit from
MPH.},
Doi = {10.1200/JCO.2004.04.128},
Key = {fds271108}
}
@article{fds271114,
Author = {Thompson, RJ and Gustafson, KE and Bonner, MJ and Ware,
RE},
Title = {Neurocognitive development of young children with sickle
cell disease through three years of age.},
Journal = {J Pediatr Psychol},
Volume = {27},
Number = {3},
Pages = {235-244},
Year = {2002},
ISSN = {0146-8693},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11909931},
Keywords = {Anemia, Sickle Cell • Child, Preschool • Cognition
Disorders • Female • Follow-Up Studies •
Helplessness, Learned • Hemoglobin SC Disease •
Hemoglobin, Sickle • Humans • Infant •
Infant, Newborn • Intelligence • Internal-External
Control • Male • Neuropsychological Tests* •
Parenting • Phenotype • Psychomotor Disorders
• Risk Factors • diagnosis • genetics •
psychology • psychology*},
Abstract = {OBJECTIVE: To determine (1) the neurocognitive development
of children with sickle cell disease (SCD) from 6 months
through 36 months of age, (2) the independent and combined
contributions of biomedical risk and parenting risk to child
neurocognitive functioning, and (3) the independent and
combined contributions of biomedical risk, parent cognitive
processes, and family functioning to parent adjustment.
METHOD: The study sample included 89 African American
children and their parents served through the Duke
University-University of North Carolina Comprehensive Sickle
Cell Center. Measures of cognitive and psychomotor
development were obtained at 6, 12, 24, and 36 months of
age, and parents completed self-report measures of the
cognitive processes of daily stress and attributional style,
psychological adjustment, and family functioning. RESULTS:
There was no significant decrease in psychomotor functioning
(PDI) over time but cognitive functioning (MDI) declined,
with a significant decrease occurring between the 12- and
24-month assessment points. At 24 months, poorer cognitive
functioning was associated with parenting risk, in terms of
a learned-helplessness attributional style, and biomedical
risk, in terms of HbSS phenotype. Levels of psychological
distress within the clinical range were reported by 24% of
the parents, and poorer parent adjustment was associated
with high levels of daily stress, less knowledge about child
development, lower expectations of efficacy, and HbSC
phenotype. CONCLUSIONS: The findings indicate that young
children with SCD are at risk for neurocognitive impairment
and provide support for the initiation of early intervention
studies to promote neurocognitive development.},
Doi = {10.1093/jpepsy/27.3.235},
Key = {fds271114}
}
@article{fds271113,
Author = {Bonner, MJ and Schumacher, E and Gustafson, KE and Thompson,
RJ},
Title = {The impact of sickle cell disease on cognitive functioning
and learning},
Journal = {School Psychology Review},
Volume = {28},
Number = {2},
Pages = {182-193},
Year = {1999},
Month = {December},
Abstract = {Sickle Cell Disease (SCD) refers to a complex group of
hereditary hematologic disorders that are most common in
people of African descent (Sickle Cell Disease Guideline
Panel, 1993). Although most children with SCD demonstrate
adequate academic functioning, some children experience
neurological insults such as strokes that can negatively
affect school performance. Even in the absence of overt
neurological disease, SCD puts some children at risk for
neuropsychological sequelae including lowered intellectual
functioning, academic skills deficits, impaired fine-motor
functioning, and attentional deficits. Studies that document
these deficits have evolved from descriptive summaries to
more methodologically sound investigations of
neuropsychological deficits with corresponding
neuroradiographic findings. These studies will be reviewed
to highlight the sometimes subtle and complex
neuropsychological impairments found in some children with
SCD. This review also will demonstrate the importance of
careful monitoring and assessment of all children with SCD
to facilitate early identification of that subset of
children with neuropsychological sequelae. Additionally,
possible indirect effects of SCD that can negatively impact
school performance will be highlighted including
absenteeism, psychological functioning, and pain coping.
Finally, recommendations for school programming are offered
to facilitate an optimal learning environment for school
children with SCD.},
Key = {fds271113}
}
@article{fds271112,
Author = {Putnam, DE and Finney, JW and Barkley, PL and Bonner,
MJ},
Title = {Enhancing commitment improves adherence to a medical
regimen.},
Journal = {J Consult Clin Psychol},
Volume = {62},
Number = {1},
Pages = {191-194},
Year = {1994},
Month = {February},
ISSN = {0022-006X},
url = {http://dx.doi.org/10.1037//0022-006x.62.1.191},
Abstract = {A commitment-based intervention was evaluated for
improvement of adherence to a 10-day antibiotic regimen.
Experimental Ss made verbal and written commitments for
adherence and completed tasks designed to increase their
investment in a medication regimen. Control Ss performed
similarly structured tasks unrelated to the medical regimen.
Adherence, measured by unannounced pill counts, was
significantly higher for experimental subjects than for
control Ss. Self-reported adherence was significantly
correlated with posttest self-efficacy but not with pretest
self-efficacy. Adherence to a medical regimen may be
improved by strategies conceptually based on the investment
model of commitment, which provides a useful framework for
further study of adherence.},
Doi = {10.1037//0022-006x.62.1.191},
Key = {fds271112}
}
@article{fds271069,
Author = {Finney, JW and Bonner, MJ},
Title = {The Influence of Behavioural Family Intervention on the
Health of Chronically Ill Children},
Journal = {Behaviour Change},
Volume = {9},
Number = {3},
Pages = {157-170},
Publisher = {Cambridge University Press (CUP)},
Year = {1992},
Month = {January},
url = {http://dx.doi.org/10.1017/S0813483900006306},
Abstract = {Chronic illnesses in children and adolescents present
difficulties for the individual and family. A family systems
perspective can provide directions for assessment and
intervention with these children and their families. A
review is made of research on family interventions for
children with juvenile rheumatoid arthritis, cancer, and
insulin-dependent diabetes mellitus (IDDM), and the
influence of intervention on health outcomes is discussed.
Few family interventions, particularly behavioural family
interventions, have been rigorously evaluated, but
multisystemic models show promise for improving children's
health outcomes and family adaptation to chronic illnesses.
© 1992, Cambridge University Press. All rights
reserved.},
Doi = {10.1017/S0813483900006306},
Key = {fds271069}
}
@article{fds271111,
Author = {Finney, JW and Bonner, MJ},
Title = {The influence of behavioral family intervention on
children's health and health care use},
Journal = {Behavior Change},
Volume = {9},
Pages = {157-170},
Year = {1992},
Key = {fds271111}
}
@article{fds271110,
Author = {Edwards, MC and Finney, JW and Bonner, M},
Title = {Matching treatment with recurrent abdominal pain symptoms:
An evaluation of dietary fiber and relaxation
treatments},
Journal = {Behavior Therapy},
Volume = {22},
Number = {2},
Pages = {257-267},
Year = {1991},
Month = {January},
ISSN = {0005-7894},
url = {http://dx.doi.org/10.1016/S0005-7894(05)80181-9},
Abstract = {We evaluated whether symptoms of recurrent abdominal pain in
children provide a basis for treatment selection. Subjects
were assigned to dietary fiber or relaxation treatments
based upon whether they presented with symptoms of
constipation. Elven subjects were treated in a combined
multiple baseline and A-B or A-B-C design. As a control,
some subjects recived the alternative treatment first. All
four subjects with symptoms of constipation showed
reductions in the number of stomachaches during the dietary
fiber treatment. Of the seven subjects without symptoms of
constipation, one showed reductions in stomachaches during
the relaxation treatment, three showed some minimal
reduction that was difficult to attribute to the relaxation
treatment, two responded to the dietary fiber treatment, and
one spontaneously improved during baseline. Results support
the effectiveness of a dietary fiber treatment for children
with symptoms of constipation. Minimal support was obtained
for the effectiveness of a relaxation treatment for children
without symptoms of constipation. Implications, limitations,
and directions for future research are discussed. © 1991
Association for Advancement of Behavior Therapy. All right
reserved.},
Doi = {10.1016/S0005-7894(05)80181-9},
Key = {fds271110}
}
%% Chapters in Books
@misc{fds312977,
Author = {Ware, RE and Davis, BR and Schultz, WH and Brown, C and Aygun, B and Sarnaik, SA and Odame, I and Fuh, B and George, A and Owen, W and Luchtman-Jones, L and Rogers, ZR and Hilliard, L and Gauger, C and Piccone, CM and Lee, MT and Kwiatkowski, J and Jackson, S and Miller,
ST and Roberts, CW and Heeney, MM and Kalfa, TA and Nelson, SC and Imran,
H and Nottage, KA and Alvarez, OA and Rhodes, M and Thompson, AA and Rothman, J and Helton, KJ and Roberts, D and Coleman, J and Bonner, MJ and Kutlar, A and Patel, N and Wood, JC and Piller, L and Wei, P and Luden, J and Mortier, NA and Stuber, S and Luban, NLC and Cohen, AR and Pressel, SL and Adams, RJ},
Title = {TCD with Transfusions Changing to Hydroxyurea (TWiTCH):
Hydroxyurea Therapy As an Alternative to Transfusions for
Primary Stroke Prevention in Children with Sickle Cell
Anemia},
Journal = {BLOOD},
Volume = {126},
Number = {23},
Pages = {3 pages},
Publisher = {AMER SOC HEMATOLOGY},
Year = {2015},
Month = {December},
ISSN = {0006-4971},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000368019000067&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds312977}
}
@misc{fds271058,
Author = {Willard, VW and Hardy, KK and Allen, TM and Hwang, EI and Gururangan, S and Hostetter, SA and Bonner, MJ},
Title = {Sluggish cognitive tempo in survivors of pediatric brain
tumors.},
Journal = {J Neurooncol},
Volume = {114},
Number = {1},
Pages = {71-78},
Year = {2013},
Month = {August},
ISSN = {1522-8517},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000270494800354&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Abstract = {The presence of neurocognitive late effects in survivors of
pediatric brain tumors is well established. However, there
remains some debate about how best to conceptualize these
deficits. Sluggish cognitive tempo (SCT) is a proposed
conceptual framework that has been used to describe a subset
of children with ADHD who exhibit a particular profile
characterized by lethargy, day dreaming and staring, and
poor organization. Previous work has suggested that
survivors of leukemia exhibit a similar profile, but it has
not yet been examined in survivors of pediatric brain
tumors. A sample of 65 survivors of pediatric brain tumors,
25 survivors of leukemia and 50 community controls completed
the Child Behavior Checklist, with four items used to
measure SCT. Survivors completed additional measures of
neurocognitive functioning. Survivors of brain tumors
demonstrated significantly greater symptoms of SCT than
survivors of leukemia or controls. SCT was associated with
attention problems and working memory deficits and the
presence of a VP-shunt. Results provided conditional support
for the presence of SCT in survivors of brain tumors, with
further research needed to determine the clinical utility of
the framework.},
Doi = {10.1007/s11060-013-1149-8},
Key = {fds271058}
}
@misc{fds271064,
Author = {Palmer, SL and Lesh, S and Wallace, D and Bonner, MJ and Swain, M and Chapieski, L and Mabbott, DJ and Knight, S and Boyle, R and Armstrong,
C and Gajjar, A},
Title = {HOW DO PARENTS COPE WITH THEIR CHILD'S DIAGNOSIS AND
TREATMENT OF AN EMBRYONAL TUMOR? RESULTS OF A PROSPECTIVE
AND LONGITUDINAL STUDY},
Journal = {NEURO-ONCOLOGY},
Volume = {12},
Number = {6},
Pages = {II16-II16},
Publisher = {OXFORD UNIV PRESS INC},
Year = {2010},
Month = {June},
ISSN = {1522-8517},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000278817700077&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds271064}
}
@misc{fds271066,
Author = {Thornburg, CD and Dixon, N and Burgett, S and Mortier, NA and Zimmerman,
SA and Bonner, MJ and Calatroni, A and Ware, RE},
Title = {Efficacy of Hydroxyurea To Prevent Organ Damage in Young
Children with Sickle Cell Anemia.},
Journal = {Blood},
Volume = {110},
Number = {11},
Pages = {3386-3386},
Publisher = {American Society of Hematology},
Year = {2007},
Month = {November},
ISSN = {0006-4971},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000251100804423&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Abstract = {<jats:title>Abstract</jats:title> <jats:p>Hydroxyurea (HU)
prevents many acute complications of sickle cell anemia
(SCA) in adults and children, but its potential to delay or
prevent chronic organ damage has not been defined. The
objectives of this prospective IRB-approved study were to
assess the safety and efficacy of HU in young children with
SCA (age 18 mon–5 years) and to determine whether 2 years
of therapy preserves renal function, reduces transcranial
doppler ultrasound (TCD) values, and prevents development of
brain ischemia as evidenced by magnetic resonance
imaging/angiography (MRI/MRA). Fourteen children with SCA
(11 male, 3 female; mean age 35±11 mon) enrolled and
underwent evaluation including blood counts, %HbF
measurement, determination of the glomerular filtration rate
(GFR) by radionuclide DTPA clearance and Schwartz estimate,
TCD mean cerebral artery (MCA) velocities, and brain
MRI/MRA. HU was started at 20 mg/kg/day and escalated by
5mg/kg/day every 8 weeks to a maximum tolerated dose (MTD)
or 30 mg/kg/day (mean dose 28±4 mg/kg). Children were
evaluated initially every 4 weeks. All baseline tests were
repeated at study exit (mean time 25±3 months). HU was
tolerated well by all children. Hematological changes
occurred as expected, with significant increases observed in
hemoglobin concentration, MCV, and %HbF and significant
decreases in reticulocytes, WBC, and neutrophils. The
average GFR value did not rise as expected in this age
range; the DTPA GFR decreased by 5.1 mL/min/1.73 m2 (p=0.26)
with only 3 of 11 exit studies exceeding 150 mL/min/1.73 m2
and the Schwartz estimate increased by 16.5 mL/min/1.73 m2
(p=0.17). During HU therapy, the average TCD values
significantly decreased with a mean decrease of 26±28
cm/sec in the right MCA (p<.01) and mean decrease of
27±33 in the left MCA (p<.05). At study entry, 3
children had conditional TCD velocities, but all were normal
at study exit. One child had mild small vessel ischemic
changes on MRI at study entry that were unchanged at study
exit. Two children had mild MRA changes that were stable or
improved at the end of the study. All children had normal or
improved rates of growth and development during therapy. Two
children required PRBC transfusion for acute events (acute
chest syndrome and hypoplastic anemia during a viral
illness). There was one episode of Moraxella catarrhalis
bacteremia that was unrelated to myelosuppression and
responded to antibiotic therapy. One child was removed from
study at week 82 due to the development of thrombocytopenia
and hypersplenism, another had acute splenic sequestration
but continued HU without recurrence, and a third child with
previous acute splenic sequestration did not have recurrence
during the study. In conclusion, HU therapy appears to be
well tolerated in young children with SCA. In addition to
providing beneficial changes in hematological parameters, HU
has salutary effects on both the kidney and brain. HU
therapy was associated with a stable GFR value during a time
interval when hyperfiltration develops, and led to
significant decreases in TCD velocities. However,
preservation of splenic tissue could lead to an increased
risk of splenic complications. Follow-up studies are
warranted to determine if long-term HU therapy can preserve
or restore organ function in this patient
population.</jats:p>},
Doi = {10.1182/blood.v110.11.3386.3386},
Key = {fds271066}
}
@misc{fds271059,
Author = {Hardy, KK and Bonner, MJ and Willard, VW and Hutchinson,
KC},
Title = {Parent and family psychosocial adjustment as a function of
pediatric tumor type},
Journal = {NEURO-ONCOLOGY},
Volume = {8},
Number = {4},
Pages = {479-479},
Publisher = {DUKE UNIV PRESS},
Year = {2006},
Month = {October},
ISSN = {1522-8517},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000240877301339&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds271059}
}
@misc{fds271062,
Author = {Hardy, KK and Bonner, MJ and Willard, VW},
Title = {Hydrocephalus as an additional risk factor for academic and
intellectual outcome in survivors of pediatric
medulloblastoma treated with radiation},
Journal = {NEURO-ONCOLOGY},
Volume = {8},
Number = {4},
Pages = {479-480},
Publisher = {DUKE UNIV PRESS},
Year = {2006},
Month = {October},
ISSN = {1522-8517},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000240877301340&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds271062}
}
@misc{fds271065,
Author = {Bonner, MJ and Hardy, KK and Willard, VW},
Title = {Fatigue in adolescent survivors of pediatric
cancer},
Journal = {NEURO-ONCOLOGY},
Volume = {8},
Number = {4},
Pages = {476-476},
Publisher = {DUKE UNIV PRESS},
Year = {2006},
Month = {October},
ISSN = {1522-8517},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000240877301327&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds271065}
}
@misc{fds271068,
Author = {Hood, MA and Anthony, KK and Bonner, MJ and Hardy, KK and Willard, VW and Schanberg, LE},
Title = {Social and nonverbal functioning in children with juvenile
rheumatoid arthritis (JRA).},
Journal = {ARTHRITIS AND RHEUMATISM},
Volume = {54},
Number = {9},
Pages = {S506-S506},
Publisher = {WILEY-LISS},
Year = {2006},
Month = {September},
ISSN = {0004-3591},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000240877202350&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds271068}
}
@misc{fds271063,
Author = {Bonner, MJ and Hardy, KK and Guill, AB and Willard, VW and Carter, KE and Gururangan, S},
Title = {Quality of life in pediatric brain tumor
survivors},
Journal = {NEURO-ONCOLOGY},
Volume = {7},
Number = {3},
Pages = {336-336},
Publisher = {DUKE UNIV PRESS},
Year = {2005},
Month = {July},
ISSN = {1522-8517},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000230463900219&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds271063}
}
@misc{fds271061,
Author = {Hardy, KK and Bonner, MJ and Bromell, L and Gururangan,
S},
Title = {Preliminary evidence of nonverbal learning disability in
survivors of pediatric brain tumors},
Journal = {NEURO-ONCOLOGY},
Volume = {6},
Number = {4},
Pages = {446-446},
Publisher = {DUKE UNIV PRESS},
Year = {2004},
Month = {October},
ISSN = {1522-8517},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000224332400511&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds271061}
}
@misc{fds359832,
Author = {Bonner, MJ and Hardy, KK and Ezell, E and Ware, R},
Title = {Hematological disorders: Sickle cell disease and
hemophilia},
Pages = {241-261},
Booktitle = {Handbook of Pediatric Psychology in School
Settings},
Year = {2003},
Month = {September},
ISBN = {9780805839173},
Key = {fds359832}
}
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