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| Publications of Richard S. Surwit :chronological alphabetical combined listing:%% Journal Articles @article{fds305793, Author = {Surwit, RS and Ross, SL and Feinglos, MN}, Title = {Stress, behavior, and glucose control in diabetes mellitus}, Pages = {97-118}, Publisher = {LAWRENCE ERLBAUM ASSOC PUBL}, Editor = {MCCABE, PM and SCHNEIDERMAN, N and FIELD, TM and SKYLER, JS}, Year = {2013}, Month = {May}, ISBN = {9780805804089}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1991BT22L00005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Doi = {10.4324/9780203771723}, Key = {fds305793} } @article{fds305767, Author = {Lane, JD and Kuhn, CM and Surwit, RS and Siegler, IC and Brummett, BH and Williams, RB}, Title = {BLOOD PRESSURE 'NON-DIPPING' STATUS IS ASSOCIATED WITH GREATER OVERNIGHT EPINEPHRINE EXCRETION}, Journal = {Psychosomatic Medicine}, Volume = {75}, Number = {3}, Pages = {A31-A31}, Publisher = {LIPPINCOTT WILLIAMS & WILKINS}, Year = {2013}, Month = {April}, ISSN = {0033-3174}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330467400104&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305767} } @article{fds305766, Author = {Georgiades, A and Brummett, BH and Siegler, IC and Surwit, RS and Kuhn, C and Grichnik, K and Stafford-Smith, M and Williams, RB}, Title = {EFFECT OF CENTRAL NERVOUS SYSTEM SEROTONIN FUNCTION ON INFLAMMATION, ADIPOSITY AND INSULIN SENSITIVITY}, Journal = {Psychosomatic Medicine}, Volume = {75}, Number = {3}, Pages = {A69-A69}, Publisher = {LIPPINCOTT WILLIAMS & WILKINS}, Year = {2013}, Month = {April}, ISSN = {0033-3174}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330467400220&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305766} } @article{fds305778, Author = {Surwit, RS and Williams, RB and Georgiades, A}, Title = {Adrenal Medullary Function, Adiposity and Fasting Glucose}, Journal = {Obesity (Silver Spring, Md.)}, Volume = {19}, Pages = {S92-S92}, Publisher = {NATURE PUBLISHING GROUP}, Year = {2011}, Month = {November}, ISSN = {1930-7381}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000296603100200&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305778} } @article{fds305788, Author = {Georgiades, A and Williams, RB and Lane, JD and Boyle, SH and Brummett, BH and Siegler, IC and Barefoot, JC and Kuhn, CM and Surwit, RS}, Title = {Plasma Epinephrine Levels Determine Fasting and Stress Induced Glucose Levels in Women With High Central Adiposity}, Journal = {Obesity (Silver Spring, Md.)}, Volume = {17}, Pages = {S54-S54}, Publisher = {NATURE PUBLISHING GROUP}, Year = {2009}, Month = {November}, ISSN = {1930-7381}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000271237800023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305788} } @article{fds305795, Author = {Surwit, RS and Kuhn, CM and Helms, MJ and Siegler, IC and Feinglos, MN and Williams, RB}, Title = {MAO-uVNTR is related to CNS serotonergic function, glucose metabolism, BMI, and hostility}, Journal = {Diabetes}, Volume = {55}, Pages = {A431-A431}, Publisher = {AMER DIABETES ASSOC}, Year = {2006}, Month = {June}, ISSN = {0012-1797}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000238055802498&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305795} } @article{fds305792, Author = {Kuhn, CM and Gadde, K and Schanberg, SM and Marchuk, DA and Siegler, IC and Surwit, RS and Williams, RB}, Title = {Serotonin transporter polymorphism influences the prolactin response to tryptophan and stress}, Journal = {Neuropsychopharmacology}, Volume = {30}, Pages = {S141-S141}, Publisher = {NATURE PUBLISHING GROUP}, Year = {2005}, Month = {December}, ISSN = {0893-133X}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000233442100375&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305792} } @article{fds305811, Author = {Collins, S and Surwit, RS and Wang, SY and Daniel, KW and Petro, AE and Snedden, SK}, Title = {Regulation of the uncoupling protein genes (UCP-1,-2,-3) by nutrients and hormones}, Journal = {Progress in Obesity Research: 8}, Pages = {373-379}, Publisher = {JOHN LIBBEY & CO}, Editor = {GuyGrand, B}, Year = {1999}, Month = {January}, ISBN = {0-86196-581-7}, ISSN = {0962-7936}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000084261200044&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305811} } @article{fds6169, Author = {R.S. Surwit and Williams, P.}, Title = {Animal models provide insight into psychosomatic factors in diabetes}, Journal = {Psychosomatic Medicine}, Volume = {58}, Pages = {582-589}, Year = {1996}, Key = {fds6169} } @article{fds305799, Author = {SURWIT, RS and MCCASKILL, CC and ROSS, SL and FEINGLOS, MN}, Title = {BEHAVIORAL AND PHARMACOLOGICAL MANIPULATION OF GLUCOSE-TOLERANCE IN TYPE-II DIABETES}, Journal = {Diabetes 1991}, Volume = {1000}, Pages = {1227-1230}, Publisher = {ELSEVIER SCIENCE PUBL B V}, Editor = {RIFKIN, H and COLWELL, JA and TAYLOR, SI}, Year = {1991}, Month = {January}, ISBN = {0-444-89254-0}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1991BV33Y00233&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305799} } %% Papers Published @article{fds348806, Author = {Surwit, RS and Williams, RB and Siegler, IC and Lane, JD and Helms, M and Applegate, KL and Zucker, N and Feinglos, MN and McCaskill, CM and Barefoot, JC}, Title = {Erratum. Hostility, race, and glucose metabolism in nondiabetic individuals. Diabetes Care 2002;25:835-839.}, Journal = {Diabetes Care}, Volume = {43}, Number = {3}, Pages = {691}, Year = {2020}, Month = {March}, url = {http://dx.doi.org/10.2337/dc20-er03}, Doi = {10.2337/dc20-er03}, Key = {fds348806} } @article{fds332663, Author = {Merwin, RM and Moskovich, AA and Honeycutt, LK and Lane, JD and Feinglos, M and Surwit, RS and Zucker, NL and Dmitrieva, NO and Babyak, MA and Batchelder, H and Mooney, J}, Title = {Time of Day When Type 1 Diabetes Patients With Eating Disorder Symptoms Most Commonly Restrict Insulin.}, Journal = {Psychosom Med}, Volume = {80}, Number = {2}, Pages = {222-229}, Year = {2018}, url = {http://dx.doi.org/10.1097/PSY.0000000000000550}, Abstract = {OBJECTIVE: Restricting insulin to lose weight is a significant problem in the clinical management of type 1 diabetes (T1D). Little is known about this behavior or how to effectively intervene. Identifying when insulin restriction occurs could allow clinicians to target typical high-risk times or formulate hypotheses regarding factors that influence this behavior. The current study investigated the frequency of insulin restriction by time of day. METHODS: Fifty-nine adults with T1D and eating disorder symptoms completed 72 hours of real-time reporting of eating and insulin dosing with continuous glucose monitoring. We used a generalized estimating equation model to test the global hypothesis that frequency of insulin restriction (defined as not taking enough insulin to cover food consumed) varied by time of day, and examined frequency of insulin restriction by hour. We also examined whether patterns of insulin restriction for 72 hours corresponded with patients' interview reports of insulin restriction for the past 28 days. RESULTS: Frequency of insulin restriction varied as a function of time (p = .016). Insulin restriction was the least likely in the morning hours (6:00-8:59 AM), averaging 6% of the meals/snacks consumed. Insulin restriction was more common in the late afternoon (3:00-5:59 PM), peaking at 29%. Insulin was restricted for 32% of the meals/snacks eaten overnight (excluding for hypoglycemia); however, overnight eating was rare. Insulin restriction was associated with higher 120-minute postprandial blood glucose (difference = 44.4 mg/dL, 95% confidence interval = 22.7-68.5, p < .001) and overall poorer metabolic control (r = 0.43-0.62, p's < .01). Patients reported restricting insulin for a greater percentage of meals and snacks for the past 28 days than during the 72 hour real-time assessment; however, the reports were correlated (Spearman's ρ = 0.46, p < .001) and accounted for similar variance in HbA1c (34% versus 35%, respectively). CONCLUSIONS: Findings suggest that insulin restriction may be less likely in the morning, and that late afternoon is a potentially important time for additional therapeutic support. Results also suggest that systematic clinical assessment and treatment of overnight eating might improve T1D management.}, Doi = {10.1097/PSY.0000000000000550}, Key = {fds332663} } @article{fds305765, Author = {Merwin, RM and Dmitrieva, NO and Honeycutt, LK and Moskovich, AA and Lane, JD and Zucker, NL and Surwit, RS and Feinglos, M and Kuo, J}, Title = {Momentary Predictors of Insulin Restriction Among Adults With Type 1 Diabetes and Eating Disorder Symptomatology.}, Journal = {Diabetes Care}, Volume = {38}, Number = {11}, Pages = {2025-2032}, Year = {2015}, Month = {November}, ISSN = {0149-5992}, url = {http://dx.doi.org/10.2337/dc15-0753}, Abstract = {OBJECTIVE: Individuals with type 1 diabetes who restrict insulin to control weight are at high risk for diabetes-related complications and premature death. However, little is known about this behavior or how to effectively intervene. The aim of the current study was to identify predictors of insulin restriction in the natural environment that might inform new treatment directions. RESEARCH DESIGN AND METHODS: Eighty-three adults with type 1 diabetes and a range of eating disorder symptomatology completed 3 days of ecological momentary assessment. Participants reported emotions, eating, and insulin dosing throughout the day using their cellular telephone. Linear mixed models were used to estimate the effects of heightened negative affect (e.g., anxiety) before eating and characteristics of the eating episode (e.g., eating a large amount of food) on the risk of insulin restriction. RESULTS: Individuals who reported greater-than-average negative affect (general negative affect and negative affect specifically about diabetes) during the study period were more likely to restrict insulin. Momentary increases in anxiety/nervousness and guilt/disgust with self before eating (relative to an individual's typical level) further increased the odds of restricting insulin at the upcoming meal. Insulin restriction was more likely when individuals reported that they broke a dietary rule (e.g., "no desserts"). CONCLUSIONS: Results suggest that insulin restriction might be decreased by helping patients with type 1 diabetes respond effectively to heightened negative affect (e.g., anxiety, guilt) and encouraging patients to take a less rigid, punitive approach to diabetes management.}, Doi = {10.2337/dc15-0753}, Key = {fds305765} } @article{fds276311, Author = {Boyle, SH and Georgiades, A and Brummett, BH and Barefoot, JC and Siegler, IC and Matson, WR and Kuhn, CM and Grichnik, K and Stafford-Smith, M and Williams, RB and Kaddurah-Daouk, R and Surwit, RS}, Title = {Associations between central nervous system serotonin, fasting glucose, and hostility in African American females.}, Journal = {Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine}, Volume = {49}, Number = {1}, Pages = {49-57}, Year = {2015}, Month = {February}, ISSN = {0883-6612}, url = {http://dx.doi.org/10.1007/s12160-014-9626-7}, Abstract = {BACKGROUND: Previous research has shown an association between hostility and fasting glucose in African American women. Central nervous system serotonin activity is implicated both in metabolic processes and in hostility related traits. PURPOSE: The purpose of this study is to determine whether central nervous system serotonin influences the association between hostility and fasting glucose in African American women. METHODS: The study consisted of 119 healthy volunteers (36 African American women, 27 White women, 21 White males, and 35 African American males, mean age 34 ± 8.5 years). Serotonin related compounds were measured in cerebrospinal fluid. Hostility was measured by the Cook-Medley Hostility Scale. RESULTS: Hostility was associated with fasting glucose and central nervous system serotonin related compounds in African American women only. Controlling for the serotonin related compounds significantly reduced the association of hostility to glucose. CONCLUSIONS: The positive correlation between hostility and fasting glucose in African American women can partly be explained by central nervous system serotonin function.}, Doi = {10.1007/s12160-014-9626-7}, Key = {fds276311} } @article{fds276310, Author = {Merwin, RM and Moskovich, AA and Dmitrieva, NO and Pieper, CF and Honeycutt, LK and Zucker, NL and Surwit, RS and Buhi, L}, Title = {Disinhibited eating and weight-related insulin mismanagement among individuals with type 1 diabetes.}, Journal = {Appetite}, Volume = {81}, Pages = {123-130}, Year = {2014}, Month = {October}, ISSN = {0195-6663}, url = {http://dx.doi.org/10.1016/j.appet.2014.05.028}, Abstract = {OBJECTIVE: Withholding insulin for weight control is a dangerous practice among individuals with type 1 diabetes; yet little is known about the factors associated with this behavior. Studies of nondiabetic individuals with weight concerns suggest that eating in a disinhibited manner (e.g., binge eating) predicts the use of maladaptive compensatory strategies (e.g., self-induced vomiting). The purpose of this study was to test whether individuals with type 1 diabetes are less restrained in their eating when they think their blood glucose (BG) is low and whether this contributes to insulin omission for weight control purposes and subsequently higher hemoglobin A1c (HbA1c). METHODS: Two-hundred and seventy-six individuals with type 1 diabetes completed an online survey of eating behaviors, insulin dosing and most recent HbA1c. We used structural equation modeling to test the hypothesis that disinhibited eating when blood sugar is thought to be low predicts weight-related insulin mismanagement, and this, in turn, predicts higher HbA1c. RESULTS: The majority of participants endorsed some degree of disinhibition when they think their blood glucose is low (e.g., eating foods they do not typically allow) and corresponding negative affect (e.g., guilt/shame). The frequency of disinhibited eating was positively associated with weight-related insulin mismanagement. Controlling for age, sex, education, and insulin pump use, the model explained 31.3% of the variance in weight-related insulin mismanagement and 16.8% of the variance in HbA1c. CONCLUSION: Addressing antecedents to disinhibited eating that are unique to type 1 diabetes (e.g., perceived BG level) and associated guilt or shame may reduce weight-related insulin omission.}, Doi = {10.1016/j.appet.2014.05.028}, Key = {fds276310} } @article{fds329825, Author = {Feinglos, M and Surwit, R and Mehr, SR}, Title = {The how and why of stress, diabetes, and the brain.}, Journal = {Am J Manag Care}, Volume = {20}, Number = {8 Spec No.}, Pages = {E3}, Year = {2014}, Month = {May}, Key = {fds329825} } @article{fds276312, Author = {Feinglos, MN and Gibb, RD and Ramsey, DL and Surwit, RS and McRorie, JW}, Title = {Psyllium improves glycemic control in patients with type-2 diabetes mellitus}, Journal = {Bioactive Carbohydrates and Dietary Fibre}, Volume = {1}, Number = {2}, Pages = {156-161}, Publisher = {Elsevier BV}, Year = {2013}, Month = {April}, ISSN = {2212-6198}, url = {http://dx.doi.org/10.1016/j.bcdf.2013.02.003}, Abstract = {Objective: This double-blind, placebo-controlled clinical study was designed to evaluate the effects of psyllium on fasting blood glucose (FBG) and HbA1c in patients being treated for type-2 diabetes mellitus (T2DM). Research design and methods: Patients were randomly assigned to 1 of the 3 treatment groups: placebo, psyllium 3.4 g BID or psyllium 6.8 g BID (just prior to breakfast and dinner). Patients had a total of 9 clinic visits during the 20-week study period (8 weeks baseline, 12 weeks treatment). A total of 37 patients [12 females, 34 Caucasians, mean age 62 years] were enrolled (8 in the placebo group, 15 in the psyllium 3.4 g BID group and 14 in the psyllium 6.8 g BID group) and were included in the Intent-to-Treat analysis. Results: Both doses of psyllium significantly (p<0.05) lowered FBG compared to placebo at treatment weeks 4, 8, and 12. Psyllium 6.8 g BID significantly lowered HbA 1c compared to placebo at Week 8 (-0.58±0.18, p=0.003), and both the 3.4 g dose and the 6.8 g dose of psyllium significantly (p<0.05) lowered HbA1c compared to placebo at Week 12 (-0.53±0.20, p=0.013; -0.65±0.20, p=0.003, respectively). Conclusions: The improvement in glycemic control observed with psyllium in T2DM patients was above that already conferred by a restricted diet (all patients) and a stable dose of a sulfonylurea (81.1% of patients). These data support that psyllium is an effective co-therapy for improving glycemic control in patients being treated for T2DM. NCT01582282. © 2013 Elsevier Ltd.}, Doi = {10.1016/j.bcdf.2013.02.003}, Key = {fds276312} } @article{fds305813, Author = {Lane, JD and Lane, AJ and Surwit, RS and Kuhn, CM and Feinglos, MN}, Title = {Pilot Study of Caffeine Abstinence for Control of Chronic Glucose in Type 2 Diabetes.}, Journal = {Journal of Caffeine Research}, Volume = {2}, Number = {1}, Pages = {45-47}, Year = {2012}, Month = {May}, ISSN = {2156-5783}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23209999}, Abstract = {BACKGROUND: A growing body of evidence suggests that caffeinated beverages may impair chronic glucose control in type 2 diabetes. This pilot study tested the chronic effects of caffeine abstinence on glucose control in type 2 diabetic patients who were daily coffee drinkers. METHODS: Twelve coffee drinkers (six males) with established type 2 diabetes participated. Seven (five males) completed 3 months of total caffeine abstinence. Measures of chronic glucose control, long-term (hemoglobin A1c [HbA1c]) and short-term (1,5-anhydroglucitol [1,5-AG]), were collected at baseline and during follow-up. Abstinence was established by diaries confirmed by saliva caffeine assays. RESULTS: Abstinence produced significant decreases in HbA1c and increases in 1,5-AG, both indicating improvements in chronic glucose control. Fasting glucose and insulin did not change, nor were changes in body weight observed. CONCLUSIONS: Although preliminary, these results suggest that caffeine abstinence may be beneficial for patients with type 2 diabetes. This hypothesis should be confirmed in larger controlled clinical trials.}, Doi = {10.1089/jcr.2012.0003}, Key = {fds305813} } @article{fds305812, Author = {Surwit, RS and Williams, RB and Lane, JD and Boyle, SH and Brummett, BH and Siegler, IC and Barefoot, JC and Kuhn, CM and Gerogiades, A}, Title = {EPINEPHRINE, TRUNK FAT AND FASTING GLUCOSE}, Journal = {Annals of Behavioral Medicine}, Volume = {43}, Pages = {S155-S155}, Publisher = {SPRINGER}, Year = {2012}, Month = {April}, ISSN = {0883-6612}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000302092400600&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305812} } @article{fds276341, Author = {Brummett, BH and Babyak, MB and Siegler, IC and Surwit, R and Georgiades, A and Boyle, SH and Williams, RB}, Title = {Systolic blood pressure and adiposity: examination by race and gender in a nationally representative sample of young adults.}, Journal = {Am J Hypertens}, Volume = {25}, Number = {2}, Pages = {140-144}, Year = {2012}, Month = {February}, url = {http://www.ncbi.nlm.nih.gov/pubmed/21976277}, Abstract = {BACKGROUND: Adiposity, or more specifically, underlying body fat distribution, has been associated with systolic blood pressure (SBP), and it has been suggested that these associations vary between whites and blacks, as well as by gender. METHODS: Here, we use data from the National Longitudinal Study of Adolescent Health (Add Health), a US study of over 15,000 participants (median age 29.0 years), to characterize the associations between measures of body fat distribution-waist circumference (WC) and WC adjusted for body mass index (BMI) (WC(-bmi))-with SBP within white and black race and gender subgroups. RESULTS: Our findings suggest that, at lower levels of WC(-bmi), white women have significantly higher SBP as compared to black women, whereas black men have higher SBP than white men. Black women with WC(-bmi) >90 cm have higher SBP compared to white women with similar WC(-bmi), whereas among black and white men the associations are essentially similar across the full range of WC(-bmi). CONCLUSIONS: The present results suggest that associations among anthropometric measures of adiposity and blood pressure are nonlinear, and importantly, vary for whites and blacks by gender. In black women, SBP increased more as WC increased from low- to mid-range levels, whereas it was only at higher WC levels that black men exhibited higher SBP than white men.}, Doi = {10.1038/ajh.2011.177}, Key = {fds276341} } @article{fds276334, Author = {Surwit, RS and Williams, RB and Lane, JD and Feinglos, MN and Kuhn, CM and Georgiades, A}, Title = {Plasma epinephrine predicts fasting glucose in centrally obese African-American women.}, Journal = {Obesity (Silver Spring)}, Volume = {18}, Number = {9}, Pages = {1683-1687}, Year = {2010}, Month = {September}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20300086}, Abstract = {The high prevalence of diabetes in African-American (AA) women has been widely assumed to be related to the greater prevalence of obesity in this group. Catecholamine release acting on central adipose tissue has been proposed to be a contributing factor. The aim of this article was to examine the interaction of plasma catecholamines and central adiposity on fasting and nonfasting glucose levels in two separate samples. In both studies, the women were healthy, nondiabetic of similar age. In addition, both studies assessed plasma epinephrine (EPI) and norepinephrine (NOREPI) levels collected at three time points. In study 1, catecholamines were measured during a standardized laboratory mental stress task and in study 2, they were measured during the initial phase (10 min) of an intravenous glucose tolerance test (IVGTT). Results from both studies revealed significant effects of EPI on fasting glucose in the obese women. In study 1, mean EPI levels were significantly related to fasting glucose in AA women with high trunk fat (beta = 0.60, P < 0.001). Because high BMI was associated with high trunk fat in women, we used BMI >30 as a proxy for high trunk fat (>32%) in study 2. In study 2, EPI response to the glucose bolus was a strong predictor of fasting glucose in AA women with BMI >30 (beta = 0.75, P < 0.003). We conclude that the effect of central adiposity on fasting glucose may be moderated by plasma EPI. This suggests that adrenal medullary activity could play a role in the pathophysiology of type 2 diabetes.}, Doi = {10.1038/oby.2010.43}, Key = {fds276334} } @article{fds276345, Author = {Williams, RB and Surwit, RS and Siegler, IC and Ashley-Koch, AE and Collins, AL and Helms, MJ and Georgiades, A and Boyle, SH and Brummett, BH and Barefoot, JC and Grichnik, K and Stafford-Smith, M and Suarez, EC and Kuhn, CM}, Title = {Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men.}, Journal = {Psychosom Med}, Volume = {72}, Number = {7}, Pages = {601-607}, Year = {2010}, Month = {September}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20595415}, Abstract = {OBJECTIVE: To use measures of cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5HIAA) and genotype of a functional polymorphism of the monoamine oxidase A gene promoter (MAOA-uVNTR) to study the role of central nervous system (CNS) serotonin in clustering of hostility, other psychosocial, metabolic and cardiovascular endophenotypes. METHODS: In 86 healthy male volunteers, we evaluated CSF levels of the primary serotonin metabolite 5HIAA and MAOA-uVNTR genotype for association with a panel of 29 variables assessing hostility, other psychosocial, metabolic, and cardiovascular endophenotypes. RESULTS: The correlations of 5HIAA with these endophenotypes in men with more active MAOA-uVNTR alleles were significantly different from those of men with less active alleles for 15 of the 29 endophenotypes. MAOA-uVNTR genotype and CSF 5HIAA interacted to explain 20% and 22% of the variance, respectively, in scores on one factor wherein high scores reflected a less healthy psychosocial profile and a second factor wherein high score reflected increased insulin resistance, body mass index, blood pressure and hostility. In men with less active alleles, higher 5HIAA was associated with more favorable profiles of hostility, other psychosocial, metabolic and cardiovascular endophenotypes; in men with more active alleles, higher 5HIAA was associated with less favorable profiles. CONCLUSIONS: These findings indicate that, in men, indices of CNS serotonin function influence the expression and clustering of hostility, other psychosocial, metabolic and cardiovascular endophenotypes that have been shown to increase risk of developing cardiovascular disease. The findings are consistent with the hypothesis that increased CNS serotonin is associated with a more favorable psychosocial/metabolic/cardiovascular profile, whereas decreased CNS serotonin function is associated with a less favorable profile.}, Doi = {10.1097/PSY.0b013e3181eb9d67}, Key = {fds276345} } @article{fds276333, Author = {Surwit, RS and Lane, JD and Millington, DS and Zhang, H and Feinglos, MN and Minda, S and Merwin, R and Kuhn, CM and Boston, RC and Georgiades, A}, Title = {Hostility and minimal model of glucose kinetics in African American women.}, Journal = {Psychosom Med}, Volume = {71}, Number = {6}, Pages = {646-651}, Year = {2009}, Month = {July}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19561162}, Abstract = {OBJECTIVE: To explore the underlying physiology of hostility (HOST) and to test the hypothesis that HOST has a greater impact on fasting glucose in African American (AA) women than it does on AA men or white men or women, using an intravenous glucose tolerance test (IVGTT) and the minimal model of glucose kinetics. METHODS: A total of 115 healthy subjects selected for high or low scores on the 27 item Cook Medley HOST Scale underwent an IVGTT. Fasting nonesterified fatty acids (NEFA) levels were measured before the IVGTT. Catecholamine levels were measured 10 minutes into the IVGTT. RESULTS: Moderation by group (AA women versus others) of HOST was found for glucose effectiveness (Sg, p = .02), acute insulin response (AIRg, p = .02), and disposition index (DI, p = .02). AA women showed a negative association between HOST and both Sg (beta = -0.45, p = .04) and DI (beta = -0.49, p = .02), controlling for age and body mass index. HOST was also associated with changes in epinephrine (beta = 0.39, p = .05) and fasting NEFA (beta = 0.44, p = .02) in the AA women. Controlling for fasting NEFA reduced the effect of HOST on both Sg and DI. CONCLUSIONS: This study shows that HOST is related to decreased DI, a measure of pancreatic compensation for increased insulin resistance as well as decreased Sg, a measure of noninsulin-mediated glucose transport compared in AA women. These effects are partly mediated by the relationship of HOST to fasting NEFA.}, Doi = {10.1097/PSY.0b013e3181acee4c}, Key = {fds276333} } @article{fds276338, Author = {Georgiades, A and Lane, JD and Boyle, SH and Brummett, BH and Barefoot, JC and Kuhn, CM and Feinglos, MN and Williams, RB and Merwin, R and Minda, S and Siegler, IC and Suarez, EC and Surwit, RS}, Title = {Hostility and fasting glucose in African American women.}, Journal = {Psychosom Med}, Volume = {71}, Number = {6}, Pages = {642-645}, Year = {2009}, Month = {July}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19553288}, Abstract = {OBJECTIVE: To examine whether the relationship of hostility (HOST) to fasting glucose indices is moderated by sex and race. HOST has been associated with abnormalities in glucose metabolism. Prior studies suggested that this association may be more prevalent in women and in African American (AA) individuals. METHODS: A total of 565 healthy AA and white (W) men and women (mean age = 33 +/- 6 years) were assessed. HOST was measured by the 27-item version of the Cook Medley HOST Scale. The moderating effects of sex and race were evaluated for the associations of HOST to fasting glucose, insulin, and insulin sensitivity (HOMA-IR). RESULTS: Analysis showed a moderating effect of sex and race on the association of HOST to fasting glucose (p = .03), but not for insulin (p = .12). Analysis of HOMA-IR revealed a trend (p = .06) for the interaction. Stratified analyses by race and sex revealed a positive association between HOST and fasting glucose only in AA women, which remained significant after controlling for age and body mass index. CONCLUSION: A relationship between HOST and fasting glucose was evident in AA women only, a group that has twice the risk of developing Type 2 diabetes compared with W women. Further studies are needed to elucidate the mechanisms by which HOST may affect glucose metabolism in AA women.}, Doi = {10.1097/PSY.0b013e3181acee3a}, Key = {fds276338} } @article{fds276340, Author = {Newgard, CB and An, J and Bain, JR and Muehlbauer, MJ and Stevens, RD and Lien, LF and Haqq, AM and Shah, SH and Arlotto, M and Slentz, CA and Rochon, J and Gallup, D and Ilkayeva, O and Wenner, BR and Yancy, WS and Eisenson, H and Musante, G and Surwit, R and Millington, DS and Butler, MD and Svetkey, LP}, Title = {A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance (DOI:10.1016/j.cmet.2009.02.002)}, Journal = {Cell Metabolism}, Volume = {9}, Number = {6}, Pages = {565-566}, Publisher = {Elsevier BV}, Year = {2009}, Month = {May}, ISSN = {1550-4131}, url = {http://dx.doi.org/10.1016/j.cmet.2009.05.001}, Doi = {10.1016/j.cmet.2009.05.001}, Key = {fds276340} } @article{fds276339, Author = {Newgard, CB and An, J and Bain, JR and Muehlbauer, MJ and Stevens, RD and Lien, LF and Haqq, AM and Shah, SH and Arlotto, M and Slentz, CA and Rochon, J and Gallup, D and Ilkayeva, O and Wenner, BR and Yancy, WS and Eisenson, H and Musante, G and Surwit, RS and Millington, DS and Butler, MD and Svetkey, LP}, Title = {A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.}, Journal = {Cell Metab}, Volume = {9}, Number = {4}, Pages = {311-326}, Year = {2009}, Month = {April}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19356713}, Abstract = {Metabolomic profiling of obese versus lean humans reveals a branched-chain amino acid (BCAA)-related metabolite signature that is suggestive of increased catabolism of BCAA and correlated with insulin resistance. To test its impact on metabolic homeostasis, we fed rats on high-fat (HF), HF with supplemented BCAA (HF/BCAA), or standard chow (SC) diets. Despite having reduced food intake and a low rate of weight gain equivalent to the SC group, HF/BCAA rats were as insulin resistant as HF rats. Pair-feeding of HF diet to match the HF/BCAA animals or BCAA addition to SC diet did not cause insulin resistance. Insulin resistance induced by HF/BCAA feeding was accompanied by chronic phosphorylation of mTOR, JNK, and IRS1Ser307 and by accumulation of multiple acylcarnitines in muscle, and it was reversed by the mTOR inhibitor, rapamycin. Our findings show that in the context of a dietary pattern that includes high fat consumption, BCAA contributes to development of obesity-associated insulin resistance.}, Doi = {10.1016/j.cmet.2009.02.002}, Key = {fds276339} } @article{fds276325, Author = {Zhang, H and Stevens, RD and Young, SP and Surwit, R and Georgiades, A and Boston, R and Millington, DS}, Title = {A convenient LC-MS method for assessment of glucose kinetics in vivo with D-[13C6]glucose as a tracer.}, Journal = {Clin Chem}, Volume = {55}, Number = {3}, Pages = {527-532}, Year = {2009}, Month = {March}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19181735}, Abstract = {BACKGROUND: The isotope-labeled intravenous glucose tolerance test (IVGTT) combined with computer modeling is widely used to derive parameters related to glucose metabolism in vivo. Most of these methods involve use of either (2)H(2)-labeled or (13)C(1)-labeled D-glucose as a tracer with GC-MS to measure the isotope enrichment. These methods are challenging, both technologically and economically. We have developed a novel approach that is suitable for labeled-IVGTT studies involving a large cohort of individuals. METHODS: The tracer, D-[(13)C(6)]glucose, is a low-cost alternative with the significant advantage that the sixth isotope of natural glucose has virtually zero natural abundance, which facilitates isotopomer analysis with <1% labeled glucose in the infusate. After deproteinization of plasma samples collected at various times, glucose is converted to a stable derivative, purified by solid-phase extraction (SPE), and analyzed by HPLC-electrospray ionization mass spectrometry to accumulate the isotope-abundance data for the A+2, A+3, and A+6 ions of the glucose derivative. A 2-pool modeling program was used to derive standard kinetic parameters. RESULTS: With labeled-IVGTT data from 10 healthy male individuals, the values for insulin sensitivity, glucose effectiveness, and the plasma clearance rate estimated with the 2-pool minimal model compared well with values obtained via traditional methods. CONCLUSIONS: The relative simplicity and robustness of the new method permit the preparation and analysis of up to 48 samples/day, a throughput equivalent to 2 complete IVGTT experiments, and this method is readily adaptable to existing 96 well-format purification and analytical systems.}, Doi = {10.1373/clinchem.2008.113654}, Key = {fds276325} } @article{fds276344, Author = {Brummett, BH and Boyle, SH and Siegler, IC and Kuhn, CM and Surwit, RS and Garrett, ME and Collins, A and Ashley-Koch, A and Williams, RB}, Title = {HPA axis function in male caregivers: effect of the monoamine oxidase-A gene promoter (MAOA-uVNTR).}, Journal = {Biol Psychol}, Volume = {79}, Number = {2}, Pages = {250-255}, Year = {2008}, Month = {October}, url = {http://www.ncbi.nlm.nih.gov/pubmed/18639608}, Abstract = {Caregiving stress is associated with negative health outcomes. Neuroendocrine functioning may be a mediator of such outcomes. The MAOA gene regulates activity of neurotransmitters involved with neuroendocrine responses to stress. Differences in polymorphisms of this gene have been shown to influence susceptibility to stress. Therefore, we examined allelic variation in MAOA-uVNTR, a functional polymorphism of MAOA, as a moderator of chronic stress effects on urinary cortisol excretion in 74 males enrolled in a case/control study of caregivers for relatives with dementia. Mixed models analysis of variance were used to examine MAOA-uVNTR genotype (3 repeats vs. 3.5/4 repeats) as a moderator of the impact of stress (caregiver vs. non-caregiver) on the urinary excretion pattern (overnight, daytime, evening) of cortisol. Caregivers with MAOA-uVNTR alleles associated with less transcriptional activity (3-repeats) displayed a pattern of cortisol excretion -- a decrease from overnight to daytime -- that was suggestive of HPA axis blunting, as compared to non-caregivers and those caregivers with the more active alleles (3.5/4 repeats) (cortisol p<.043). Individuals with less active MAOA-uVNTR alleles who are under chronic stress may be at increased risk for exhaustion of the HPA response to such stress.}, Doi = {10.1016/j.biopsycho.2008.06.004}, Key = {fds276344} } @article{fds276346, Author = {O'Shea, SI and Arcasoy, MO and Samsa, G and Cummings, SE and Thames, EH and Surwit, RS and Ortel, TL}, Title = {Direct-to-patient expert system and home INR monitoring improves control of oral anticoagulation.}, Journal = {Journal of Thrombosis and Thrombolysis}, Volume = {26}, Number = {1}, Pages = {14-21}, Year = {2008}, Month = {August}, ISSN = {0929-5305}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17616845}, Abstract = {BACKGROUND AND OBJECTIVE: Internet-based disease management programs have the potential to improve patient care. The objective of this study was to determine whether an interactive, internet-based system enabling supervised, patient self-management of oral anticoagulant therapy provided management comparable to an established anticoagulation clinic. PATIENTS/METHODS: Sixty patients receiving chronic oral anticoagulant therapy who had access to the internet and a printer, were enrolled into this prospective, single-group, before-after study from a single clinic and managed between March 2002 and January 2003. Patients learned how to use a home prothrombin time monitor and how to access the system through the internet. Patients used the system for six months, with daily review by the supervising physician. The primary outcome variable was the difference in time in therapeutic range prior to and following introduction of internet-supervised patient self-management. RESULTS: The mean time in therapeutic range increased from 63% in the anticoagulation clinic (control period) to 74.4% during internet-supervised patient self-management (study period). The mean difference score between control and study periods was 11.4% (P = 0.004, 95% confidence interval 5.5-17.3%). There were no hemorrhagic or thromboembolic complications. CONCLUSIONS: This novel approach of internet-supervised patient self-management improved time in therapeutic range compared to an anticoagulation clinic. This is the first demonstration of an internet-based expert system enabling remote and effective management of patients on oral anticoagulants. Expert systems may be applicable for management of other chronic diseases.}, Doi = {10.1007/s11239-007-0068-y}, Key = {fds276346} } @article{fds276332, Author = {Lane, JD and Feinglos, MN and Surwit, RS}, Title = {Caffeine increases ambulatory glucose and postprandial responses in coffee drinkers with type 2 diabetes.}, Journal = {Diabetes Care}, Volume = {31}, Number = {2}, Pages = {221-222}, Year = {2008}, Month = {February}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17977936}, Doi = {10.2337/dc07-1112}, Key = {fds276332} } @article{fds276343, Author = {Williams, RB and Marchuk, DA and Siegler, IC and Barefoot, JC and Helms, MJ and Brummett, BH and Surwit, RS and Lane, JD and Kuhn, CM and Gadde, KM and Ashley-Koch, A and Svenson, IK and Suarez, EC and Schanberg, SM}, Title = {Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stress.}, Journal = {Psychosom Med}, Volume = {70}, Number = {1}, Pages = {32-39}, Year = {2008}, Month = {January}, url = {http://www.ncbi.nlm.nih.gov/pubmed/18158371}, Abstract = {OBJECTIVE: To test the hypothesis that low socioeconomic status (SES) and the 5HTTLPR L allele are associated with increased cardiovascular reactivity (CVR) to stress in a larger sample and that SES and 5HTTLPR genotypes interact to enhance CVR to stress. CVR to mental stress has been proposed as one mechanism linking stress to the pathogenesis of cardiovascular disease. The more transcriptionally efficient long (L) allele of a polymorphism of the serotonin transporter gene promoter (5HTTLPR) has been found associated with increased risk of myocardial infarction. We found the long allele associated with larger CVR to mental stress in a preliminary study of 54 normal volunteers. METHODS: Subjects included 165 normal community volunteers stratified for race, gender, and SES, who underwent mental stress testing. RESULTS: Childhood SES as indexed by Father's Education Level was associated with larger systolic blood pressure (SBP) (p < .05) and diastolic blood pressure (DBP) (p = .01) responses to mental stress. The L allele was associated with larger SBP (p = .04), DBP (p < .0001), and heart rate (p = .04) responses to mental stress compared with the short (S) allele. Subjects with the SS genotype and high Father's Education exhibited smaller SBP (5.2 mm Hg) and DBP (2.9 mm Hg) responses than subjects with LL genotype and low Father's Education (SBP = 13.3 mm Hg, p = .002; DBP = 9.7 mm Hg, p < .0001). CONCLUSIONS: Both the 5HTTLPR long allele and low SES, particularly during childhood, are associated with increased CVR to mental stress, which could account, at least in part, for the increased cardiovascular disease risk associated with these characteristics. If confirmed in further research, these characteristics could be used to identify persons who might benefit from preventive interventions.}, Doi = {10.1097/PSY.0b013e31815f66c3}, Key = {fds276343} } @article{fds305808, Author = {Lane, JD and Prince, C and Feinglos, MN and Surwit, RS}, Title = {CAFFEINE EXAGGERATES POSTPRANDIAL INSULIN RESISTANCE IN ADULTS AT RISK FOR TYPE 2 DIABETES}, Journal = {Annals of Behavioral Medicine}, Volume = {33}, Pages = {S33-S33}, Publisher = {SPRINGER}, Year = {2007}, Month = {December}, ISSN = {0883-6612}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000261185300124&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305808} } @article{fds276337, Author = {Boyle, SH and Surwit, RS and Georgiades, A and Brummett, BH and Helms, MJ and Williams, RB and Barefoot, JC}, Title = {Depressive symptoms, race, and glucose concentrations: the role of cortisol as mediator.}, Journal = {Diabetes Care}, Volume = {30}, Number = {10}, Pages = {2484-2488}, Year = {2007}, Month = {October}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17630268}, Abstract = {OBJECTIVE: This study examined the associations of depressive symptoms with glucose concentrations and morning cortisol levels in 665 African-American and 4,216 Caucasian Vietnam-era veterans. RESEARCH DESIGN AND METHODS: Glucose level was measured as a three-level variable (diabetes, impaired glucose, and normal). Depressive symptoms were measured by the Obvious Depression Scale (OBD) from the Minnesota Multiphasic Personality Inventory. RESULTS: Regression models showed significant race x OBD interactions in relation to glucose concentration (P < 0.0001) and cortisol (P < 0.0001). The OBD was positively associated with glucose concentration and cortisol in both racial groups. However, the magnitude of those associations was larger for African Americans. Further analyses suggested that cortisol partially mediated the race difference in the relation of depressive symptoms to glucose concentrations. CONCLUSIONS: These results suggest that enhanced hypothalamic pituitary adrenal activity plays an important role in the relation of depressive symptoms to dysregulated glucose metabolism and may partially explain the differential effects of depressive symptoms on glucose levels in African-American and Caucasian male subjects.}, Doi = {10.2337/dc07-0258}, Key = {fds276337} } @article{fds276342, Author = {Brummett, BH and Krystal, AD and Siegler, IC and Kuhn, C and Surwit, RS and Züchner, S and Ashley-Koch, A and Barefoot, JC and Williams, RB}, Title = {Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality.}, Journal = {Psychosom Med}, Volume = {69}, Number = {5}, Pages = {396-401}, Year = {2007}, Month = {June}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17585061}, Abstract = {OBJECTIVE: To examine the relationships among the variable number of tandem repeats in the monoamine oxidase-A linked polymorphic region allelic variation (MAOA-uVNTR) and the symptoms of depression and sleep quality. The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. MAOA-uVNTR genotype has been associated with both psychological and physical measures. METHODS: The sample consisted of 74 males enrolled in a case/control study of caregivers for relatives with dementia. Age- and race-adjusted linear regression models were used to examine the association between low versus high MAOA-uVNTR activity alleles, symptoms of depression (Center for Epidemiological Studies of Depression), and sleep quality ratings (Pittsburgh Sleep Quality Index). RESULTS: MAOA-uVNTR alleles associated with less transcriptional activity were related to increased symptoms of depression (p < .04; Cohen's d = 0.52) and poorer sleep quality (p < .04; Cohen's d = 0.31). CONCLUSIONS: Individuals with less active MAOA-uVNTR alleles may be at increased risk for depressive symptoms and poor sleep.}, Doi = {10.1097/PSY.0b013e31806d040b}, Key = {fds276342} } @article{fds276347, Author = {Georgiades, A and Zucker, N and Friedman, KE and Mosunic, CJ and Applegate, K and Lane, JD and Feinglos, MN and Surwit, RS}, Title = {Changes in depressive symptoms and glycemic control in diabetes mellitus.}, Journal = {Psychosom Med}, Volume = {69}, Number = {3}, Pages = {235-241}, Year = {2007}, Month = {April}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17420441}, Abstract = {OBJECTIVE: To investigate if changes in depressive symptoms would be associated with changes in glycemic control over a 12-month period in patients with Type 1 and Type 2 diabetes. METHODS: Ninety (Type 1 diabetes, n = 28; Type 2 diabetes, n = 62) patients having Beck Depression Inventory (BDI) levels of >10 were enrolled in the study. Of those 90 patients, 65 patients completed a 12-week cognitive behavioral therapy intervention. BDI was assessed at baseline and thereafter biweekly during 12 months. Hemoglobin (HbA1c) and fasting blood glucose levels were assessed at baseline and at four quarterly in-hospital follow-up visits. Linear mixed-model analysis was applied to determine the effects of time and diabetes type on depressive symptoms, HbA1c levels, and fasting glucose levels. RESULTS: Mean and standard deviation baseline BDI and HbA1c levels were 17.9 +/- 5.8 and 7.6 +/- 1.6, respectively, with no significant difference between patients with Type 1 and Type 2 diabetes. Mixed-model regression analysis found no difference between the groups with Type 1 and Type 2 diabetes in the within-subject effect of BDI score on HbA1c or fasting glucose levels during the study. Depressive symptoms decreased significantly (p = .0001) and similarly over a 12-month period in both patients with Type 1 and Type 2 diabetes, whereas HbA1c and fasting glucose levels did not change significantly over time in either group. CONCLUSION: Changes in depressive symptoms were not associated with changes in HbA1c or fasting glucose levels over a 1-year period in either patients with Type 1 or Type 2 diabetes.}, Doi = {10.1097/PSY.0b013e318042588d}, Key = {fds276347} } @article{fds276331, Author = {Lane, JD and Hwang, AL and Feinglos, MN and Surwit, RS}, Title = {Exaggeration of postprandial hyperglycemia in patients with type 2 diabetes by administration of caffeine in coffee.}, Journal = {Endocr Pract}, Volume = {13}, Number = {3}, Pages = {239-243}, Year = {2007}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17599854}, Abstract = {OBJECTIVE: To test whether caffeine administered in coffee increases postprandial hyperglycemia in patients with type 2 diabetes who are habitual coffee drinkers. METHODS: The study used a within-subject, double-blind, placebo-controlled experimental design. Twenty adult coffee drinkers (11 women and 9 men) with type 2 diabetes treated with diet, exercise, orally administered antidiabetic agents, or some combination of these factors completed two mixed-meal tolerance tests (MMTT) after an overnight fast. Before the MMTT, each study participant received 250 mg of caffeine in 16 oz (475 mL) of decaffeinated coffee or decaffeinated coffee alone, with the treatment order counterbalanced in the group. Fasting and 1-hour and 2-hour postprandial blood samples were collected for measurement of plasma glucose and insulin concentrations. RESULTS: Glucose and insulin responses to the MMTT were quantified by the incremental areas under the 2-hour concentration-time curves (AUC2h). Administration of caffeine in decaffeinated coffee increased postprandial glucose and insulin responses (both P = 0.02). The mean plasma glucose AUC2h was 28% larger and the mean plasma insulin AUC2h was 19% larger after administration of caffeine than after administration of placebo. CONCLUSION: Other constituents in coffee did not prevent the exaggeration of postprandial hyperglycemia by caffeine in these patients with type 2 diabetes, who were habitual coffee drinkers. Repeated on a daily basis, such effects could impair long-term glucose control in those patients with type 2 diabetes who habitually drink coffee or other caffeinated beverages.}, Doi = {10.4158/EP.13.3.239}, Key = {fds276331} } @article{fds276330, Author = {Surwit, RS and van Tilburg, MAL and Parekh, PI and Lane, JD and Feinglos, MN}, Title = {Treatment regimen determines the relationship between depression and glycemic control.}, Journal = {Diabetes Research and Clinical Practice}, Volume = {69}, Number = {1}, Pages = {78-80}, Year = {2005}, Month = {July}, ISSN = {0168-8227}, url = {http://www.ncbi.nlm.nih.gov/pubmed/15955389}, Abstract = {UNLABELLED: Several recent studies have suggested that depression is related to poorer glycemic control in patients with type 1 diabetes, but not in type 2 diabetes. We hypothesize that complexity of self-care regimen rather than the type of diabetes, is more important in determining this relationship of depression to glycemic control. METHODS: One thousand thirty-four adults with diabetes were recruited for the study. These patients were treated with: diet and exercise, oral medications, oral medications and insulin, 1-2 daily injections of insulin, and > or =3 daily injections. All participants completed the Beck depression inventory (BDI) and had a hemoglobin A(1c) (HbA(1c)) performed as part of routine clinical care. RESULTS: Pearson correlations between BDI scores and HbA(1c) were low and insignificant in all groups (0.015< or =r< or =0.066) except for those administering three or more daily shots of insulin (r=0.284; p=0.034). DISCUSSION: The results of this study clearly show that while depressive symptoms are significantly correlated to glycemic control in patients taking three or more insulin injections per day, there is no relationship in patients who are taking fewer than three injections per day.}, Doi = {10.1016/j.diabres.2004.11.002}, Key = {fds276330} } @article{fds276336, Author = {Brummett, BH and Siegler, IC and Rohe, WM and Barefoot, JC and Vitaliano, PP and Surwit, RS and Feinglos, MN and Williams, RB}, Title = {Neighborhood characteristics moderate effects of caregiving on glucose functioning.}, Journal = {Psychosom Med}, Volume = {67}, Number = {5}, Pages = {752-758}, Year = {2005}, url = {http://www.ncbi.nlm.nih.gov/pubmed/16204434}, Abstract = {OBJECTIVE: Adverse neighborhood environments and caregiving for a relative with dementia are both stressors that have been associated with poor health. The present study examined the extent to which three self-report measures of neighborhood characteristics interact with caregiving status (caregiver versus noncaregiver) to modify an important stress related health outcome: plasma glucose. METHODS: The study sample consisted of 147 community recruited caregivers and 147 participants who did not have caregiving responsibilities. We hypothesized that negative neighborhood characteristics would magnify effects of caregiving on plasma glucose levels. Regression analyses were conducted to examine the interaction of three neighborhood characteristic measures with caregiving status in predicting fasting plasma glucose (FPG) and glycosylated hemoglobin concentration (HbA1c), with control for age, race, gender, relation to care recipient (spouse or relative), body mass index, income, and education. RESULTS: Of the three neighborhood measures, the one reflecting crime concerns significantly moderated the effect of caregiving on FPG (p < .002) and HbA1c (p < .001). For participants with better neighborhood characteristics, caregivers and noncaregivers were similar with respect to indicators of glucose metabolism; however, for participants with worse neighborhood characteristics, caregivers had higher levels of FPG and HbA1c, as compared with noncaregivers. CONCLUSIONS: Poor health outcomes, such as impaired glucose control, may be found among caregivers who fear neighborhood crime.}, Doi = {10.1097/01.psy.0000174171.24930.11}, Key = {fds276336} } @article{fds276329, Author = {Lane, JD and Barkauskas, CE and Surwit, RS and Feinglos, MN}, Title = {Caffeine impairs glucose metabolism in type 2 diabetes.}, Journal = {Diabetes Care}, Volume = {27}, Number = {8}, Pages = {2047-2048}, Year = {2004}, Month = {August}, ISSN = {0149-5992}, url = {http://www.ncbi.nlm.nih.gov/pubmed/15277438}, Doi = {10.2337/diacare.27.8.2047}, Key = {fds276329} } @article{fds276322, Author = {Petro, AE and Cotter, J and Cooper, DA and Peters, JC and Surwit, SJ and Surwit, RS}, Title = {Fat, carbohydrate, and calories in the development of diabetes and obesity in the C57BL/6J mouse.}, Journal = {Metabolism: Clinical and Experimental}, Volume = {53}, Number = {4}, Pages = {454-457}, Year = {2004}, Month = {April}, ISSN = {0026-0495}, url = {http://www.ncbi.nlm.nih.gov/pubmed/15045691}, Abstract = {We have previously shown that the C57BL/6J (B6) mouse will develop obesity and diabetes if raised on a high-fat diet. Because high fat feeding is associated with hyperphagia, the present study was designed to separate the effects of fat from those of excess caloric consumption in this animal model. B6 mice were fed a low-fat diet (LF group) diet, high-fat diet (HF group) diet, or high-fat-restricted diet (HFR group), in which intake animals were pair-fed a high-fat diet to caloric level consumed by LF for 11 weeks. Within 3 weeks, HFR were significantly heavier than LF and, after 11 weeks, weight and glucose levels, but not insulin, were significantly increased in HFR when compared to LF. Body composition analysis showed the weight increase in HFR arose from an increase in percent fat consumed. We conclude that reducing the number of kilocalories consumed from a high-fat diet attenuates but does not prevent the development of type 2 diabetes and obesity in the B6 mouse.}, Doi = {10.1016/j.metabol.2003.11.018}, Key = {fds276322} } @article{fds276323, Author = {Collins, S and Martin, TL and Surwit, RS and Robidoux, J}, Title = {Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics.}, Journal = {Physiology & Behavior}, Volume = {81}, Number = {2}, Pages = {243-248}, Year = {2004}, Month = {April}, ISSN = {0031-9384}, url = {http://www.ncbi.nlm.nih.gov/pubmed/15159170}, Abstract = {The development of the metabolic syndrome in an increasing percentage of the populations of Western societies, particularly in the United States, requires valid models for establishing basic biochemical changes and performing preclinical studies on potential drug targets. The C57BL/6J mouse has become an important model for understanding the interplay between genetic background and environmental challenges such as high-fat/high-calorie diets that predispose to the development of the metabolic syndrome. This review highlights metabolic and signal transduction features that are altered during the course of disease progression, many of which mirror the human situation.}, Doi = {10.1016/j.physbeh.2004.02.006}, Key = {fds276323} } @article{fds276383, Author = {Berger, JP and Petro, AE and Macnaul, KL and Kelly, LJ and Zhang, BB and Richards, K and Elbrecht, A and Johnson, BA and Zhou, G and Doebber, TW and Biswas, C and Parikh, M and Sharma, N and Tanen, MR and Thompson, GM and Ventre, J and Adams, AD and Mosley, R and Surwit, RS and Moller, DE}, Title = {Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator.}, Journal = {Molecular Endocrinology (Baltimore, Md.)}, Volume = {17}, Number = {4}, Pages = {662-676}, Year = {2003}, Month = {April}, ISSN = {0888-8809}, url = {http://www.ncbi.nlm.nih.gov/pubmed/12554792}, Keywords = {Adipocytes • Adipose Tissue • Animals • Cardiomegaly • Cells, Cultured • Gene Expression Regulation • Hyperglycemia • Indoles • Insulin Resistance • Magnetic Resonance Spectroscopy • Male • Mice • Mice, Inbred C57BL • Models, Molecular • Protein Conformation • Receptors, Cytoplasmic and Nuclear • Sulfides • Transcription Factors • Weight Gain • agonists* • chemically induced • chemistry* • drug effects • drug therapy • pharmacology* • physiology}, Abstract = {Antidiabetic thiazolidinediones (TZDs) and non-TZD compounds have been shown to serve as agonists of the peroxisome proliferator-activated receptor gamma (PPARgamma). Here, we report the identification and characterization of a novel non-TZD selective PPARgamma modulator (nTZDpa). nTZDpa bound potently to PPARgamma with high selectivity vs. PPARalpha or PPARdelta. In cell-based assays for transcriptional activation, nTZDpa served as a selective, potent PPARgamma partial agonist and was able to antagonize the activity of PPARgamma full agonists. nTZDpa also displayed partial agonist effects when its ability to promote adipogenesis in 3T3-L1 cells was evaluated. Assessment of protein conformation using protease protection or solution nuclear magnetic resonance spectroscopy methods showed that nTZDpa produced altered PPARgamma conformational stability vs. full agonists, thereby establishing a physical basis for its observed partial agonism. DNA microarray analysis of RNA from 3T3-L1 adipocytes treated with nTZDpa or several structurally diverse PPARgamma full agonists demonstrated qualitative differences in the affected gene expression profile for nTZDpa. Chronic treatment of fat-fed, C57BL/6J mice with nTZDpa or a TZD full agonist ameliorated hyperglycemia and hyperinsulinemia. However, unlike the TZD, nTZDpa caused reductions in weight gain and adipose depot size. Feed efficiency was also substantially diminished. Unlike TZDs, nTZDpa did not cause cardiac hypertrophy in mice. When a panel of PPARgamma target genes was examined in white adipose tissue, nTZDpa produced a different in vivo expression pattern vs. the full agonist. These findings establish that novel selective PPARgamma modulators can produce altered receptor conformational stability leading to distinctive gene expression profiles, reduced adipogenic cellular effects, and potentially improved in vivo biological responses. Such compounds may lead to preferred therapies for diabetes, obesity, or metabolic syndrome.}, Doi = {10.1210/me.2002-0217}, Key = {fds276383} } @article{fds276321, Author = {Brown, NW and Ward, A and Surwit, R and Tiller, J and Lightman, S and Treasure, JL and Campbell, IC}, Title = {Evidence for metabolic and endocrine abnormalities in subjects recovered from anorexia nervosa.}, Journal = {Metabolism: Clinical and Experimental}, Volume = {52}, Number = {3}, Pages = {296-302}, Year = {2003}, Month = {March}, url = {http://dx.doi.org/10.1053/meta.2003.50067}, Abstract = {Subjects with anorexia nervosa (AN) at low weight display metabolic, endocrine, and behavioral abnormalities. Whether these various differences are a consequence of the condition and persist after recovery is unclear. We tested the hypothesis that abnormalities in the insulin and leptin axes and in the desire to eat persisted in subjects who had recovered from AN in terms of body mass index (BMI) and menstrual function. Endocrine, metabolic, and psychological parameters were assessed by sampling under fasting conditions and serially in response to a standard meal. Subjects included 18 females recovered from AN and 18 female controls and measures included plasma insulin, leptin, glucose and beta-hydroxybutyrate (beta-HBA) concentrations together with desire to eat. Fasting glucose concentrations were normal in both groups, but fasting insulin concentrations were significantly lower and the fasting glucose/insulin ratio significantly higher in the recovered subjects. The glucose concentration was significantly higher at the end of the meal period in the recovered group. The peak increase of insulin during the meal was significantly less in the recovered group and in response to the meal, glucose/insulin ratios were significantly higher for the first 45 minutes indicating a delayed insulin response. Fasting beta-HBA concentrations were not significantly different between groups, but postmeal decreases were significant and larger in the recovered AN group. Fasting and meal-related leptin concentrations were not significantly different between the groups and in both groups were correlated with BMI. In controls, but not in recovered subjects, the reported desire to eat was correlated with plasma glucose and leptin concentrations. The insulin, glucose and beta-HBA data indicated the presence of insulin hypersensitivity in the recovered subjects. As the insulin response to the meal was blunted and apparently delayed, there may be a persistent alteration in pancreatic function as a long-term pathological consequence of the anorexia. Alternatively, these data indicate a possible trait marker for AN.}, Doi = {10.1053/meta.2003.50067}, Key = {fds276321} } @article{fds276373, Author = {Surwit, RS and Williams, RB and Siegler, IC and Lane, JD and Helms, M and Applegate, KL and Zucker, N and Feinglos, MN and McCaskill, CM and Barefoot, JC}, Title = {Hostility, race, and glucose metabolism in nondiabetic individuals.}, Journal = {Diabetes Care}, Volume = {25}, Number = {5}, Pages = {835-839}, Year = {2002}, Month = {May}, ISSN = {0149-5992}, url = {http://www.ncbi.nlm.nih.gov/pubmed/11978677}, Keywords = {Adult • African Americans • African Continental Ancestry Group* • Blood Glucose • Body Mass Index • Diabetes Mellitus • European Continental Ancestry Group* • Female • Health Behavior* • Hostility* • Humans • Insulin • Male • Personality • Risk Factors • United States • analysis • blood* • epidemiology • ethnology* • metabolism* • psychology}, Abstract = {OBJECTIVE: The present study was designed to determine whether hostility is differentially related to measures of glucose metabolism in African-Americans and Caucasians. RESEARCH DESIGN AND METHODS: The relationship of hostility, as measured by a subset of the Cook-Medley hostility scale (CMHOST) inventory items, to various parameters of glucose metabolism were examined in a young, healthy sample of male and female African-American and Caucasian volunteers. Fasting blood samples were collected during an inpatient admission, at which time the CMHOST was also administered. RESULTS: In the entire sample, the CMHOST was found to be significantly correlated with fasting glucose and insulin sensitivity, as measured by the homeostatic model assessment (HOMA). However, the relationship of hostility to these parameters of glucose metabolism was different in African-American and Caucasian subjects. Hostility was significantly related to fasting glucose in African-Americans and to insulin sensitivity and fasting insulin in Caucasian subjects. The relationship of hostility to insulin sensitivity and fasting insulin was partially dependent on BMI in Caucasians, but the relationship of hostility to fasting glucose was unrelated to BMI in African-Americans. CONCLUSIONS: Our data suggest that the relationship of hostility to measures of glucose metabolism is mediated differently in these two ethnic groups. Therefore, hostility seems to be part of a constellation of risk-related behaviors related to BMI in Caucasians but independently related to fasting glucose in African-Americans.}, Doi = {10.2337/diacare.25.5.835}, Key = {fds276373} } @article{fds276328, Author = {Williams, PG and Colder, CR and Lane, JD and McCaskill, CC and Feinglos, MN and Surwit, RS}, Title = {Examination of the neuroticism-symptom reporting relationship in individuals with type 2 diabetes}, Journal = {Personality & Social Psychology Bulletin}, Volume = {28}, Number = {8}, Pages = {1015-1025}, Publisher = {SAGE Publications}, Year = {2002}, Month = {January}, ISSN = {0146-1672}, url = {http://dx.doi.org/10.1177/01461672022811001}, Abstract = {The current study utilized a within-subject, experience sampling methodology (ESM) to examine the relationship between neuroticism (N) and physical symptom reports. Individuals with type 2 diabetes monitored diabetes-related symptoms, rated negative and positive affect (NA and PA), estimated their blood glucose (BG) levels, and tested their actual BG levels with a glucometer four times per day for 7 days. Multilevel modeling analyses indicated that N, NA, and PA were related to reported symptom frequency. Neuroticism moderated the relation between PA and symptom reports: Lower PA was more strongly related to symptom reports among high-N individuals. In addition, there was evidence that symptoms mediated the relationship between N and state NA. Finally, N was related to overestimation of BG, beyond that accounted for by state NA. Results are discussed with respect to potential effects of N on the processing of negative self-relevant information and on self-regulatory behavior in health contexts. © 2002 by the Society for Personality and Social Psychology, Inc.}, Doi = {10.1177/01461672022811001}, Key = {fds276328} } @article{fds276403, Author = {Surwit, RS and van Tilburg, MAL and Zucker, N and McCaskill, CC and Parekh, P and Feinglos, MN and Edwards, CL and Williams, P and Lane, JD}, Title = {Stress management improves long-term glycemic control in type 2 diabetes.}, Journal = {Diabetes Care}, Volume = {25}, Number = {1}, Pages = {30-34}, Year = {2002}, Month = {January}, ISSN = {0149-5992}, url = {http://www.ncbi.nlm.nih.gov/pubmed/11772897}, Keywords = {Blood Glucose • Continental Population Groups • Diabetes Mellitus, Type 2 • Energy Intake • Female • Hemoglobin A, Glycosylated • Humans • Male • Manifest Anxiety Scale • Middle Aged • Patient Compliance • Patient Education • Personality Inventory • Questionnaires • Stress, Psychological • analysis • blood • metabolism* • methods* • prevention & control* • psychology* • rehabilitation}, Abstract = {OBJECTIVE: There is conflicting evidence regarding the utility of stress management training in the treatment of diabetes. The few studies that have shown a therapeutic effect of stress management have used time-intensive individual therapy. Unfortunately, widespread use of such interventions is not practical. The aim of the present investigation is to determine whether a cost-effective, group-based stress management training program can improve glucose metabolism in patients with type 2 diabetes and to determine whether a particular subset of patients is more likely to get positive results. RESEARCH DESIGN AND METHODS: Patients with type 2 diabetes were randomized to undergo a five-session group diabetes education program with or without stress management training. Participants (n = 108) were followed for 1 year, during which HbA(1c) tests and questionnaires assessing perceived stress, anxiety, and psychological health were administered at regular intervals to evaluate treatment effects. RESULTS: Stress management training was associated with a small (0.5%) but significant reduction in HbA(1c). Compliance with the treatment regimen decreased over time but was similar to that seen in patients receiving stress management for other reasons in the clinic. Trait anxiety (a measure of stable individual differences in anxiety proneness) did not predict response to treatment, showing that highly anxious patients did not derive more benefit from training. CONCLUSIONS: The current results indicate that a cost-effective, group stress management program in a "real-world" setting can result in clinically significant benefits for patients with type 2 diabetes.}, Doi = {10.2337/diacare.25.1.30}, Key = {fds276403} } @article{fds276319, Author = {Collins, S and Cao, W and Daniel, KW and Dixon, TM and Medvedev, AV and Onuma, H and Surwit, R}, Title = {Adrenoceptors, uncoupling proteins, and energy expenditure.}, Journal = {Experimental Biology and Medicine}, Volume = {226}, Number = {11}, Pages = {982-990}, Year = {2001}, Month = {December}, ISSN = {1535-3702}, url = {http://www.ncbi.nlm.nih.gov/pubmed/11743133}, Abstract = {Interest in the biology of adipose tissue has undergone a revival in recent years with the discovery of a host of genes that contribute to the regulation of satiety and metabolic rate. The catecholamines have long been known to be key modulators of adipose tissue lipolysis and the hydrolysis of triglyceride energy stores. However, more recent efforts to understand the role of individual adrenergic receptor subtypes expressed in adipocytes and their signal transduction pathways have revealed a complexity not previously appreciated. Combined with this interest in the modulation of adipocyte metabolism is a renewed focus upon brown adipose tissue and the mechanisms of whole body thermogenesis in general. The discovery of novel homologs of the brown fat uncoupling protein (UCP) such as UCP2 and UCP3 has provoked intensive study of these mitochondrial proteins and the role that they play in fuel metabolism. The story of the novel UCPs has proven to be intriguing and still incompletely understood. Here, we review the status of adipose tissue from inert storage depot to endocrine organ, interesting signal transduction pathways triggered by beta-adrenergic receptors in adipocytes, the potential of these receptors for discriminating and coordinated metabolic regulation, and current views on the role of UCP2 and UCP3 based on physiological studies and gene knockout models.}, Doi = {10.1177/153537020122601104}, Key = {fds276319} } @article{fds305779, Author = {Petro, AE and Cotter, J and Surwit, SJ and Cooper, DA and Peters, JC and Surwit, RS}, Title = {Independent effects of fat vs calories on diabetes and obesity.}, Journal = {Obesity Research}, Volume = {9}, Pages = {111S-111S}, Publisher = {NORTH AMER ASSOC STUDY OBESITY}, Year = {2001}, Month = {September}, ISSN = {1071-7323}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000171076300235&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305779} } @article{fds305768, Author = {Tanen, M and Petro, A and Wu, MS and Doebber, TW and Moller, DE and Surwit, RS and Berger, J}, Title = {Amelioration of diabetes and remodeling of adipose tissue by PPAR gamma agonists: Possible roles for uncoupling proteins}, Journal = {Diabetes}, Volume = {50}, Pages = {A522-A523}, Publisher = {AMER DIABETES ASSOC}, Year = {2001}, Month = {June}, ISSN = {0012-1797}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000168964302154&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305768} } @article{fds305804, Author = {Wang, YF and Chen, JS and Wang, K and Feinglos, MN and Surwit, RS}, Title = {Diabetes increases the risk of hypertension in young, non-obese, urban and rural Chinese}, Journal = {Diabetes}, Volume = {50}, Pages = {A216-A216}, Publisher = {AMER DIABETES ASSOC}, Year = {2001}, Month = {June}, ISSN = {0012-1797}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000168964300886&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305804} } @article{fds305806, Author = {Surwit, RS and Siegler, IC and Feinglos, MN and Helms, MJ and Applegate, K and Williams, RB and Scroll, M and Barefoot, JC}, Title = {Hostility predicts fasting glucose, insulin, and risk for type 2 diabetes}, Journal = {Diabetes}, Volume = {50}, Pages = {A85-A85}, Publisher = {AMER DIABETES ASSOC}, Year = {2001}, Month = {June}, ISSN = {0012-1797}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000168964300342&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305806} } @article{fds276381, Author = {Surwit, RS and Collins, S}, Title = {Revisiting lessons from the C57BL/6J mouse.}, Journal = {American Journal of Physiology. Endocrinology and Metabolism}, Volume = {280}, Number = {5}, Pages = {E825-E826}, Year = {2001}, Month = {May}, ISSN = {0193-1849}, url = {http://www.ncbi.nlm.nih.gov/pubmed/11315708}, Keywords = {Animals • Leptin • Mice • Mice, Inbred C57BL • Mice, Inbred Strains • Obesity • metabolism • metabolism* • physiology*}, Doi = {10.1152/ajpendo.2001.280.5.E825}, Key = {fds276381} } @article{fds276367, Author = {Wing, RR and Goldstein, MG and Acton, KJ and Birch, LL and Jakicic, JM and Sallis, JF and Smith-West, D and Jeffery, RW and Surwit, RS}, Title = {Behavioral science research in diabetes: lifestyle changes related to obesity, eating behavior, and physical activity.}, Journal = {Diabetes Care}, Volume = {24}, Number = {1}, Pages = {117-123}, Year = {2001}, Month = {January}, ISSN = {0149-5992}, url = {http://www.ncbi.nlm.nih.gov/pubmed/11194216}, Keywords = {Behavior Therapy • Behavioral Medicine* • Body Weight • Diabetes Mellitus • Diabetes Mellitus, Type 2 • Diet • Eating • Exercise • Humans • Hyperphagia • Life Style • Obesity • Research* • prevention & control • prevention & control* • therapy • therapy*}, Abstract = {Lifestyle factors related to obesity, eating behavior, and physical activity play a major role in the prevention and treatment of type 2 diabetes. In recent years, there has been progress in the development of behavioral strategies to modify these lifestyle behaviors. Further research, however, is clearly needed, because the rates of obesity in our country are escalating, and changing behavior for the long term has proven to be very difficult. This review article, which grew out of a National Institute of Diabetes and Digestive and Kidney Diseases conference on behavioral science research in diabetes, identifies four key topics related to obesity and physical activity that should be given high priority in future research efforts: 1) environmental factors related to obesity, eating, and physical activity; 2) adoption and maintenance of healthful eating, physical activity, and weight; 3) etiology of eating and physical activity; and 4) multiple behavior changes. This review article discusses the significance of each of these four topics, briefly reviews prior research in each area, identifies barriers to progress, and makes specific research recommendations.}, Doi = {10.2337/diacare.24.1.117}, Key = {fds276367} } @article{fds141567, Title = {Surwit, R.S. and Collins, S. Revisting lessons from the C57BL/6J mouse. American Journal of Physiology-Endocrinology and Metabolism, 2001, 280, E825-E826 (letter).}, Year = {2001}, Key = {fds141567} } @article{fds141618, Title = {Wing, R.R., Goldstein, M.G., Acton, K.J., Birch, L.L., Jakicic, J.M., Sallis, J.F., West, D.S., Jeffrey, R.W., and Surwit, R.S. Behavioral science research in diabetes: Lifestyle changes related to obesity and physical activity. Diabetes Care, 2001, 24, 117-123.}, Year = {2001}, Key = {fds141618} } @article{fds141619, Title = {Van Tilburg, M.A.L., McCaskill, C.C., Lane, J.D., Edwards, C.L., Bethel, A., Feinglos, M.N., and Surwit, R.S. Depressed mood is a factor in glycemic control in type 1, diabetes. Psychosomatic Medicine, 2001, 63, 551-555.}, Year = {2001}, Key = {fds141619} } @article{fds141620, Title = {Collins, S., Cao, W., Daniel, K.W., Dixon, T.M., Medvedev, A.V., Onuma, H. and Surwit, R. Adrenoceptors, Uncoupling Proteins, and Energy Expenditure. Experimental Biology and Medicine 2001 226, 982-990.}, Year = {2001}, Key = {fds141620} } @article{fds276376, Author = {Collins, S and Surwit, RS}, Title = {The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis.}, Journal = {Recent Progress in Hormone Research}, Volume = {56}, Pages = {309-328}, Year = {2001}, ISSN = {0079-9963}, url = {http://www.ncbi.nlm.nih.gov/pubmed/11237219}, Keywords = {Adipose Tissue • Animals • Cell Differentiation • Cyclic AMP • Cyclic AMP-Dependent Protein Kinases • Humans • MAP Kinase Signaling System • Mice • Models, Biological • Obesity • Receptors, Adrenergic, beta • Receptors, Adrenergic, beta-3 • Signal Transduction • Sympathetic Nervous System • Temperature • Time Factors • metabolism • metabolism* • physiology*}, Abstract = {The beta-adrenergic receptors (betaARs) are members of the large family of G protein-coupled receptors. There are three betaAR subtypes (beta1AR, beta2AR beta3AR), each of which is coupled to Galphas and the stimulation of intracellular cAMP levels. While beta1AR and beta2AR are broadly expressed throughout tissues of the body, beta3AR is found predominantly in adipocytes. Stimulation of the betaARs leads to lipolysis in white adipocytes and nonshivering thermogenesis in brown fat. However, in essentially all animal models of obesity, the betaAR system is dysfunctional and the ability to stimulate lipolysis and thermogenesis is impaired. Nevertheless, we and others have shown that selective beta3AR agonists are able to prevent or reverse obesity and the loss of betaAR expression and to stimulate thermogenesis. This chapter will review the current understanding of the role of the sympathetic nervous system and the adipocyte betaARs in models of obesity; the physiologic impact of changes in betaAR expression on body composition and thermogenesis; and the regulation and unique properties of betaAR subtypes in brown and white adipocytes. The latter includes our recent discovery of novel signal transduction mechanisms utilized by beta3AR to activate simultaneously the protein kinase A and MAP kinase pathways. The impact of understanding these pathways and their potential role in modulating adaptive thermogenesis is discussed.}, Doi = {10.1210/rp.56.1.309}, Key = {fds276376} } @article{fds276425, Author = {Van Tilburg and MA and McCaskill, CC and Lane, JD and Edwards, CL and Bethel, A and Feinglos, MN and Surwit, RS}, Title = {Depressed mood is a factor in glycemic control in type 1 diabetes.}, Journal = {Psychosomatic Medicine}, Volume = {63}, Number = {4}, Pages = {551-555}, Year = {2001}, ISSN = {0033-3174}, url = {http://www.ncbi.nlm.nih.gov/pubmed/11485108}, Keywords = {Adult • Aged • Blood Glucose • Depression • Diabetes Mellitus, Type 1 • Diabetes Mellitus, Type 2 • Female • Hemoglobin A, Glycosylated • Humans • Male • Middle Aged • Personality Inventory • Sick Role* • blood • metabolism* • psychology • psychology*}, Abstract = {OBJECTIVE: The diabetes literature contains conflicting evidence on the relationship between depression and glycemic control. This may be due, in part, to the fact that past studies failed to distinguish between patients with type 1 and type 2 diabetes. Because these are actually completely different diseases that are often treated differently and consequently make different demands on patients, the relationship between glycemic control and depressed mood in type 1 and type 2 diabetes was examined separately. METHODS: The relationship between Beck Depression Inventory (BDI) scores and HbA1c, as an index of long-term glycemic control, was measured in samples of 30 patients with type 1 and 34 patients with type 2 diabetes. RESULTS: Groups of patients with type 1 and type 2 diabetes did not differ in mean BDI score or HbA1c level. Correlation analysis revealed a significant positive relationship between BDI scores and HbA1c in the type 1 group (r = .44, p < .02) but not in the type 2 group (r = -0.06, p > .05). This relationship was evident throughout the entire range of BDI scores and was not restricted to scores indicative of clinical depression. Patients with type 1 diabetes who had higher HbA1c and BDI scores reported a lower frequency of home blood glucose monitoring. CONCLUSIONS: Variations in depressive mood, below the level of clinical depression, are associated with meaningful differences in glycemic control in type 1 but not type 2 diabetes. Preliminary data analysis suggests that this effect may be mediated, at least in part, by decreased self-care behaviors in patients with more depressed mood.}, Doi = {10.1097/00006842-200107000-00005}, Key = {fds276425} } @article{fds276324, Author = {Watkins, LL and Surwit, RS and Sherwood, A}, Title = {Glycemic control and impaired autonomic function: Is glucose the sole culprit? [11]}, Journal = {Diabetes Care}, Volume = {23}, Number = {12}, Pages = {1863-1864}, Year = {2000}, Month = {December}, ISSN = {0149-5992}, Key = {fds276324} } @article{fds276317, Author = {Arsenijevic, D and Onuma, H and Pecqueur, C and Raimbault, S and Manning, BS and Miroux, B and Couplan, E and Alves-Guerra, MC and Goubern, M and Surwit, R and Bouillaud, F and Richard, D and Collins, S and Ricquier, D}, Title = {Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production.}, Journal = {Nature Genetics}, Volume = {26}, Number = {4}, Pages = {435-439}, Year = {2000}, Month = {December}, ISSN = {1061-4036}, url = {http://www.ncbi.nlm.nih.gov/pubmed/11101840}, Abstract = {The gene Ucp2 is a member of a family of genes found in animals and plants, encoding a protein homologous to the brown fat uncoupling protein Ucp1 (refs 1-3). As Ucp2 is widely expressed in mammalian tissues, uncouples respiration and resides within a region of genetic linkage to obesity, a role in energy dissipation has been proposed. We demonstrate here, however, that mice lacking Ucp2 following targeted gene disruption are not obese and have a normal response to cold exposure or high-fat diet. Expression of Ucp2 is robust in spleen, lung and isolated macrophages, suggesting a role for Ucp2 in immunity or inflammatory responsiveness. We investigated the response to infection with Toxoplasma gondii in Ucp2-/- mice, and found that they are completely resistant to infection, in contrast with the lethality observed in wild-type littermates. Parasitic cysts and inflammation sites in brain were significantly reduced in Ucp2-/- mice (63% decrease, P<0.04). Macrophages from Ucp2-/- mice generated more reactive oxygen species than wild-type mice (80% increase, P<0.001) in response to T. gondii, and had a fivefold greater toxoplasmacidal activity in vitro compared with wild-type mice (P<0.001 ), which was absent in the presence of a quencher of reactive oxygen species (ROS). Our results indicate a role for Ucp2 in the limitation of ROS and macrophage-mediated immunity.}, Doi = {10.1038/82565}, Key = {fds276317} } @article{fds276369, Author = {Surwit, RS and Dixon, TM and Petro, AE and Daniel, KW and Collins, S}, Title = {Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes.}, Journal = {Endocrinology}, Volume = {141}, Number = {10}, Pages = {3630-3637}, Year = {2000}, Month = {October}, ISSN = {0013-7227}, url = {http://www.ncbi.nlm.nih.gov/pubmed/11014217}, Keywords = {Adipocytes • Adipose Tissue • Animals • Blood Glucose • Body Weight • Diabetes Mellitus • Diazoxide • Diet • Energy Intake • Glucose • Insulin • Leptin • Lipids • Male • Mice • Mice, Inbred Strains • Muscle, Skeletal • Obesity • Organ Size • Receptors, Adrenergic, beta • Syndrome • adverse effects* • analysis • blood • drug effects • etiology • metabolism • metabolism* • pathology • pharmacology* • physiology • physiopathology}, Abstract = {We previously demonstrated that the expression and function of the adipocyte-specific beta3-adrenergic receptor (beta3AR) are significantly depressed in single gene and diet-induced rodent models of obesity. Furthermore, these models are relatively unresponsive to the anti-obesity effects of beta3AR agonists. Because all of these models are hyperinsulinemic, we hypothesized that hyperinsulinemia could be responsible for this abnormality in beta3AR function. The goal of this study was to determine whether lowering insulin with the K-ATP channel agonist, diazoxide (Dz) would reverse the depressed expression and function of the beta3AR found in a model of diet-induced diabetes and obesity in C57BL/6J (B6) mice. B6 male mice were placed on either high fat (HF) or low fat experimental diets. After 4 weeks, HF-fed mice were assigned to a group: HF or HF containing disodium (R,R)-5- [2-( [2-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl-1,3-benzodioxole-2,2-di carboxylate (CL; 0.001%, wt/wt), Dz (0.32%, wt/wt), or their combination (CLDz). Dz animals exhibited significantly reduced plasma insulin levels as well as increased 3pAR expression and agonist-stimulated adenylyl cyclase activity in adipocytes. CLDz was more effective in reducing percent body fat, lowering nonesterified fatty acids, improving glucose tolerance, and reducing feed efficiency than either treatment alone.}, Doi = {10.1210/endo.141.10.7726}, Key = {fds276369} } @article{fds305787, Author = {Surwit, RS}, Title = {Hyperinsulinemia leptin resistance, and obesity}, Journal = {Obesity Research}, Volume = {8}, Pages = {6S-6S}, Publisher = {NORTH AMER ASSOC STUDY OBESITY}, Year = {2000}, Month = {October}, ISSN = {1071-7323}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000089876100022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305787} } @article{fds276378, Author = {Lane, JD and McCaskill, CC and Williams, PG and Parekh, PI and Feinglos, MN and Surwit, RS}, Title = {Personality correlates of glycemic control in type 2 diabetes.}, Journal = {Diabetes Care}, Volume = {23}, Number = {9}, Pages = {1321-1325}, Year = {2000}, Month = {September}, ISSN = {0149-5992}, url = {http://www.ncbi.nlm.nih.gov/pubmed/10977026}, Keywords = {Adult • Affect • Behavior Therapy • Blood Glucose • Blood Glucose Self-Monitoring • Cohort Studies • Diabetes Mellitus, Type 2 • Female • Hemoglobin A, Glycosylated • Humans • Longitudinal Studies • Male • Personality Inventory • Personality* • Questionnaires • Stress, Psychological • analysis • blood* • metabolism* • prevention & control • psychology*}, Abstract = {OBJECTIVE: To determine whether traits of normal personality are associated with variations in glycemic control in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A longitudinal cohort study was conducted using data from 105 type 2 diabetic patients in a clinical trial of a stress management intervention. Before treatment assignment, patients completed the NEO Personality Inventory, Revised, which is a questionnaire inventory measuring 5 major domains of normal personality and 30 important traits that define these domains. Glycemic control was assessed by measures of HbA1c and average blood glucose levels based on 7 days of self-monitoring at baseline and at 6 and 12 months. Relationships between personality traits and measures of glycemic control were examined by correlation and linear regression models that were adjusted for age, sex, race, duration of diabetes, medication status, and experimental treatment. RESULTS: Lower average blood glucose values at baseline were associated with higher scores for the personality domain of neuroticism and several specific traits including anxiety, angry hostility depression, self-consciousness, and vulnerability but were associated with lower scores for the trait of altruism. Results were similar for HbA1c but were not as strong. Follow-up results were similar but were less consistent. CONCLUSIONS: Personality traits may offer new insights into variations in glycemic control in patients with type 2 diabetes undergoing standard management. The relative tendency to experience fewer negative emotions and to focus on the needs of others instead of oneself could prove to be a risk factor for poor glycemic control.}, Doi = {10.2337/diacare.23.9.1321}, Key = {fds276378} } @article{fds276393, Author = {Surwit, RS and Edwards, CL and Murthy, S and Petro, AE}, Title = {Transient effects of long-term leptin supplementation in the prevention of diet-induced obesity in mice.}, Journal = {Diabetes}, Volume = {49}, Number = {7}, Pages = {1203-1208}, Year = {2000}, Month = {July}, ISSN = {0012-1797}, url = {http://www.ncbi.nlm.nih.gov/pubmed/10909979}, Keywords = {Adipose Tissue • Animals • Blood Glucose • Body Temperature • Body Weight • Diet, Fat-Restricted • Dietary Fats* • Eating • Infusions, Parenteral • Insulin • Leptin • Male • Mice • Mice, Inbred A • Mice, Inbred C57BL • Motor Activity • Obesity • Organ Size • Time Factors • administration & dosage • anatomy & histology • blood • drug effects • drug effects* • etiology • metabolism • pathology • pharmacology* • prevention & control*}, Abstract = {Low plasma leptin levels have been shown to be associated with the development of obesity in mice as well as in humans. The present study was undertaken to determine if raising plasma leptin levels of obesity-prone C57BL/6J (B6) mice to those seen in obesity-resistant A/J mice would prevent the development of diet-induced obesity. Four-week-old B6 (n = 40) and A/J (n = 10) male mice were weaned onto a low-fat (11% kcal) diet. When the animals weighed 20 g, their diets were changed to a high-fat (HF) diet (58% kcal), and a continuous infusion of leptin (0.4 mg x kg(-1) x day(-1)) or phosphate-buffered saline (control) was started using Alzet minipumps. The A/J mice were not treated but were included to monitor the efficacy of the minipumps in raising plasma leptin in B6 mice. The mice were followed for 12 weeks. Chronic treatment with leptin for 4 weeks raised plasma levels in B6 mice to that of A/J mice. Plasma leptin in B6 control mice remained significantly lower than A/J mice through week 4. By week 8, leptin levels in the B6 control group had risen and were similar to A/J mice. Although there were significant weight differences between B6 treated and B6 control groups for 2-3 weeks after pump implantation, these differences were transient. Ultimately, there were no weight differences between the B6 treated and B6 control groups. There were no differences in plasma glucose between B6 treated and control groups. Plasma insulin values were also not different between the 2 groups. There was no effect of leptin supplementation on locomotor activity or food intake in B6 mice. In summary, this study demonstrates that leptin supplementation in animals that show low plasma leptin levels in response to fat feeding may slow but does not prevent the subsequent development of diet-induced obesity.}, Doi = {10.2337/diabetes.49.7.1203}, Key = {fds276393} } @article{fds276410, Author = {Watkins, LL and Surwit, RS and Grossman, P and Sherwood, A}, Title = {Is there a glycemic threshold for impaired autonomic control?}, Journal = {Diabetes Care}, Volume = {23}, Number = {6}, Pages = {826-830}, Year = {2000}, Month = {June}, ISSN = {0149-5992}, url = {http://www.ncbi.nlm.nih.gov/pubmed/10841004}, Keywords = {Adult • Analysis of Variance • Autonomic Nervous System • Baroreflex • Blood Glucose • Blood Pressure • Fasting • Female • Heart Rate • Humans • Insulin • Male • Reference Values • analysis • blood* • metabolism* • physiology*}, Abstract = {OBJECTIVE: Although hyperglycemia has been recognized as a predictor of cardiovascular autonomic neuropathy in diabetic patients, the glucose threshold at which autonomic control begins to become impaired has not been evaluated. This study examined whether fasting plasma glucose (FPG) or fasting plasma insulin (FPI) is associated with reductions in baroreflex sensitivity (BRS) in healthy volunteers. RESEARCH DESIGN AND METHODS: FPG and FPI were measured after an overnight fast in 162 healthy volunteers (91 men, 71 women) who were 25-44 years of age. BRS was measured with power spectral analysis. RESULTS: Univariate analyses showed that FPG was negatively correlated with BRS (r = -0.25, P < or = 0.001) with significant reductions observed in volunteers with FPG in the upper 2 quintiles (i.e., 93-124 mg/dl). However, after adjustment for other predictors of BRS (e.g., age, blood pressure, and BMI), the relationship between FPG and BRS was no longer significant. In contrast, FPI was negatively correlated with BRS in univariate analyses (r = -0.32, P < 0.0001) as well as after covariate adjustment, with close to a 50% reduction in BRS observed in the volunteers with insulin values in the highest quintile (i.e., 16-36 microU/ml). CONCLUSIONS: These findings suggest that high normal levels of FPG are associated with reduced autonomic control secondary to the effects of aging, obesity, and elevated blood pressure on FPG levels and that elevations in FPI are associated with substantial reductions in autonomic cardiac control independent of other covariates.}, Doi = {10.2337/diacare.23.6.826}, Key = {fds276410} } @article{fds276335, Author = {Wiener, JS and Scales, MT and Hampton, J and King, LR and Surwit, R and Edwards, CL}, Title = {Long-term efficacy of simple behavioral therapy for daytime wetting in children}, Journal = {The Journal of Urology}, Volume = {164}, Number = {3 I}, Pages = {786-790}, Year = {2000}, Month = {January}, url = {http://dx.doi.org/10.1016/s0022-5347(05)67313-2}, Abstract = {Purpose: Behavioral therapy has proved benefit for children with daytime wetting but most studies have used biofeedback techniques and provide no long-term assessment of results. We previously reported similar results using simple behavioral therapy without biofeedback. We report the long-term efficacy of behavioral therapy for daytime wetting. Materials and Methods: Our program of behavioral therapy included timed voiding, modification of fluid intake, positive reinforcement techniques and pelvic floor (Kegel) exercises to promote pelvic floor strengthening and relaxation. Questionnaires to assess therapeutic efficacy were mailed to patients who had completed therapy more than 1 year previously. Results: A total of 48 patients responded. Mean ages at the time of the initial clinic visit and questionnaire were 8.2 and 12.9 years, respectively. Improvement in symptoms was noted in approximately 74% of the cases during the first year following therapy. At a mean of 4.7 years after treatment 59.4% of the patients had improved daytime urinary control, 51.1% improved daytime urinary frequency and 45.6% improved daytime urinary urgency. The frequency of urinary tract infections decreased in 56.4% of the cases. Measures of psychological well-being were also noted to be improved in a majority of patients. A total of 77.3% of the patients stated that they would recommend the program to others. Conclusions: Simple behavioral therapy without biofeedback techniques is an effective and durable first line therapy for children with daytime wetting.}, Doi = {10.1016/s0022-5347(05)67313-2}, Key = {fds276335} } @article{fds276419, Author = {Williams, PG and Surwit, RS and Babyak, MA and McCaskill, CC}, Title = {Personality predictors of mood related to dieting.}, Journal = {Journal of Consulting and Clinical Psychology}, Volume = {66}, Number = {6}, Pages = {994-1004}, Year = {1998}, Month = {December}, ISSN = {0022-006X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/9874913}, Keywords = {Adult • Affect* • Depression • Diet, Reducing • Extraversion (Psychology)* • Female • Humans • Middle Aged • Neurotic Disorders • Obesity • Personality • Psychological Tests • Regression Analysis • Self Assessment (Psychology) • Weight Loss • methods • physiology • psychology • psychology* • therapy*}, Abstract = {The clinical utility of a model of normal emotional functioning (vs. psychopathology) and the moderating effects of neuroticism (N) and extraversion (E) on mood were examined during a 6-week weight-loss trial. Participants were 40 obese women who completed measures of negative affect (NA) and positive affect (PA) weekly during the diet and measures of anxiety and depression (Beck Depression Inventory [BDI]) at pre-, mid-, and postdiet. Results indicated that (a) average NA and PA were each uniquely related to postdiet BDI scores, (b) N was significantly related to NA during the diet and postdiet BDI scores, and (c) N and E interacted to predict PA during the diet. The results suggest that assessment of personality and normal mood variation may be useful additions to weight-loss intervention and research.}, Doi = {10.1037//0022-006x.66.6.994}, Key = {fds276419} } @article{fds276415, Author = {Black, BL and Croom, J and Eisen, EJ and Petro, AE and Edwards, CL and Surwit, RS}, Title = {Differential effects of fat and sucrose on body composition in A/J and C57BL/6 mice.}, Journal = {Metabolism: Clinical and Experimental}, Volume = {47}, Number = {11}, Pages = {1354-1359}, Year = {1998}, Month = {November}, ISSN = {0026-0495}, url = {http://www.ncbi.nlm.nih.gov/pubmed/9826212}, Keywords = {Animals • Body Composition* • Dietary Fats • Dietary Sucrose • Intestines • Male • Mice • Mice, Inbred C57BL • Species Specificity • Sucrase • Weight Gain • administration & dosage* • alpha-Glucosidases • enzymology • metabolism}, Abstract = {The C57BL/6 (B6) mouse is more sensitive to the effects of a high-fat diet than the A/J strain. The B6 mouse develops severe obesity, hyperglycemia, and hyperinsulinemia when fed this dietary regimen. This study was conducted to determine the effects of dietary fat and sucrose concentrations on body composition and intestinal sucrase (EC 3.2.1.48) and maltase (EC 3.2.1.20) activity in these two mouse strains. High-fat diets, regardless of sucrose content, resulted in significant weight gain, higher body fat, and lower body protein and water content in both strains of mice. The shift toward higher body fat and lower protein and water content was far greater in the B6 strain. Low-fat, high-sucrose diets resulted in lower body weight in both strains, as well as significantly greater body protein content in B6 mice. Analysis of intestinal sucrase showed that the enzyme was less active in B6 mice when the diet was high in sucrose. Both sucrase and maltase had lower activity in the presence of high dietary fat in both mouse strains. The percent reduction of intestinal enzyme activity due to dietary fat was similar in both strains. The B6 mouse exhibits disproportionate weight gain and altered body composition on a high-fat diet. This coupled with the reduced body weight and increased body protein on a low-fat, high-sucrose diet suggests that factors-relative to fat metabolism rather than sucrose metabolism are responsible for obesity.}, Doi = {10.1016/s0026-0495(98)90304-3}, Key = {fds276415} } @article{fds141633, Author = {PI Parekh and AE Petro and JM Tiller and MN Feinglos and RS Surwit}, Title = {Reversal of diet-induced obesity and diabetes in C57BL/6J mice.}, Journal = {Metabolism: clinical and experimental, UNITED STATES}, Volume = {47}, Number = {9}, Pages = {1089-96}, Year = {1998}, Month = {September}, ISSN = {0026-0495}, Keywords = {Adipose Tissue • Animals • Blood Glucose • Body Weight • Diabetes Mellitus, Experimental • Dietary Fats • Insulin • Male • Mice • Mice, Inbred C57BL • Obesity • Species Specificity • administration & dosage* • analysis • anatomy & histology • blood • diet therapy*}, Abstract = {We have previously shown that C57BL/6J (B6) mice develop severe obesity and diabetes if weaned onto high-fat diets, whereas A/J mice tend to be obesity and diabetes-resistant. The purpose of this study was to determine if obesity and diabetes in the B6 mouse could be completely reversed by reducing dietary fat content. After 4 months, both strains consumed more calories on a high-fat diet than on a low-fat diet, and both strains showed a higher feed efficiency (FE=weight gained/calories consumed) on the high-fat diet versus the low-fat diet. However, relative to A/J mice, B6 mice demonstrated a significantly higher FE on the high-fat diet. Hyperglycemia, hyperinsulinemia, and increased adiposity were apparent in B6 mice after 4 months on the high-fat diet regardless of whether the diet was begun at weaning or 4 months later. Correlational analyses showed that adiposity was strongly related to both insulin and glucose levels in B6 mice, but only moderately related to insulin levels in A/J mice. In obese B6 mice that were switched to a low-fat diet, obesity and diabetes were completely reversed. Adiposity, fasting glucose, and fasting insulin values in these mice were equivalent to those in B6 mice of the same age that had spent 8 months on the low-fat diet. In summary, our data show that in the B6 mouse the severity of diabetes is a direct function of obesity and diabetes is completely reversible by reducing dietary fat.}, Key = {fds141633} } @article{fds276435, Author = {R.S. Surwit and Parekh, PI and Petro, AE and Tiller, JM and Feinglos, MN and Surwit, RS}, Title = {Reversal of diet-induced obesity and diabetes in C57BL/6J mice.}, Journal = {Metabolism: Clinical and Experimental}, Volume = {47}, Number = {9}, Pages = {1089-1096}, Year = {1998}, Month = {September}, ISSN = {0026-0495}, url = {http://www.ncbi.nlm.nih.gov/pubmed/9751238}, Abstract = {We have previously shown that C57BL/6J (B6) mice develop severe obesity and diabetes if weaned onto high-fat diets, whereas A/J mice tend to be obesity and diabetes-resistant. The purpose of this study was to determine if obesity and diabetes in the B6 mouse could be completely reversed by reducing dietary fat content. After 4 months, both strains consumed more calories on a high-fat diet than on a low-fat diet, and both strains showed a higher feed efficiency (FE=weight gained/calories consumed) on the high-fat diet versus the low-fat diet. However, relative to A/J mice, B6 mice demonstrated a significantly higher FE on the high-fat diet. Hyperglycemia, hyperinsulinemia, and increased adiposity were apparent in B6 mice after 4 months on the high-fat diet regardless of whether the diet was begun at weaning or 4 months later. Correlational analyses showed that adiposity was strongly related to both insulin and glucose levels in B6 mice, but only moderately related to insulin levels in A/J mice. In obese B6 mice that were switched to a low-fat diet, obesity and diabetes were completely reversed. Adiposity, fasting glucose, and fasting insulin values in these mice were equivalent to those in B6 mice of the same age that had spent 8 months on the low-fat diet. In summary, our data show that in the B6 mouse the severity of diabetes is a direct function of obesity and diabetes is completely reversible by reducing dietary fat.}, Doi = {10.1016/s0026-0495(98)90283-9}, Key = {fds276435} } @article{fds141670, Author = {JC Barefoot and BL Heitmann and MJ Helms and RB Williams and RS Surwit and IC Siegler}, Title = {Symptoms of depression and changes in body weight from adolescence to mid-life.}, Journal = {International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, ENGLAND}, Volume = {22}, Number = {7}, Pages = {688-94}, Year = {1998}, Month = {July}, ISSN = {0307-0565}, Keywords = {Adolescent • Adult • Aging • Body Mass Index • Depression • Exercise • Female • Humans • Longitudinal Studies • Male • Sex Characteristics • Smoking • Weight Gain* • complications* • physiology • psychology*}, Abstract = {OBJECTIVE: To investigate the relationship of symptoms of depression to weight changes in healthy individuals of normal weight across a follow-up of over 20 y. PARTICIPANTS AND DESIGN: College students (3885 men and 841 women) were administered a self-report depression measure in the mid-1960s. Their baseline body mass index (BMI) was calculated from their college medical records. Participants were contacted by mail in the late 1980s and asked to report their current height and weight as well as their smoking and exercise habits. Another measure of depressive symptoms was obtained from 3560 individuals at follow-up. Multiple regression models were used to relate changes in weight to depression scores while controlling for background (gender, baseline BMI and the gender by BMI interaction) and behavioral (exercise and smoking) predictors. RESULTS: The relationship between depressive symptoms and body weight change took the form of an interaction with baseline BMI (P < 0.001). Those with high baseline depression scores gained less weight than their nondepressed counterparts if they were initially lean, but more if they were initially heavy. This trend was especially strong in those with high depression scores at both baseline and follow-up. CONCLUSIONS: The findings support the hypothesis that depression exaggerates pre-existing weight change tendencies. This pattern would not have been detected by an examination of main effects alone, illustrating the need to move toward more complicated interactive models in the study of psychological factors and weight.}, Key = {fds141670} } @article{fds276436, Author = {R.S. Surwit and Barefoot, JC and Heitmann, BL and Helms, MJ and Williams, RB and Surwit, RS and Siegler, IC}, Title = {Symptoms of depression and changes in body weight from adolescence to mid-life.}, Journal = {Int J Obes Relat Metab Disord}, Volume = {22}, Number = {7}, Pages = {688-694}, Year = {1998}, Month = {July}, url = {http://www.ncbi.nlm.nih.gov/pubmed/9705031}, Abstract = {OBJECTIVE: To investigate the relationship of symptoms of depression to weight changes in healthy individuals of normal weight across a follow-up of over 20 y. PARTICIPANTS AND DESIGN: College students (3885 men and 841 women) were administered a self-report depression measure in the mid-1960s. Their baseline body mass index (BMI) was calculated from their college medical records. Participants were contacted by mail in the late 1980s and asked to report their current height and weight as well as their smoking and exercise habits. Another measure of depressive symptoms was obtained from 3560 individuals at follow-up. Multiple regression models were used to relate changes in weight to depression scores while controlling for background (gender, baseline BMI and the gender by BMI interaction) and behavioral (exercise and smoking) predictors. RESULTS: The relationship between depressive symptoms and body weight change took the form of an interaction with baseline BMI (P < 0.001). Those with high baseline depression scores gained less weight than their nondepressed counterparts if they were initially lean, but more if they were initially heavy. This trend was especially strong in those with high depression scores at both baseline and follow-up. CONCLUSIONS: The findings support the hypothesis that depression exaggerates pre-existing weight change tendencies. This pattern would not have been detected by an examination of main effects alone, illustrating the need to move toward more complicated interactive models in the study of psychological factors and weight.}, Doi = {10.1038/sj.ijo.0800647}, Key = {fds276436} } @article{fds276437, Author = {R.S. Surwit and Surwit, RS and Wang, S and Petro, AE and Sanchis, D and Raimbault, S and Ricquier, D and Collins, S}, Title = {Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice.}, Journal = {Proceedings of the National Academy of Sciences of the United States of America}, Volume = {95}, Number = {7}, Pages = {4061-4065}, Year = {1998}, Month = {March}, ISSN = {0027-8424}, url = {http://www.ncbi.nlm.nih.gov/pubmed/9520493}, Abstract = {Uncoupling protein 2 (UCP2) maps to a region on distal mouse chromosome 7 that has been linked to the phenotypes of obesity and type II diabetes. We recently reported that UCP2 expression is increased by high fat feeding in adipose tissue of the A/J strain of mice, which is resistant to the development of dietary obesity. More recently, a third UCP (UCP3) was identified, which is expressed largely in skeletal muscle and brown adipose tissue. The UCP2 and UCP3 genes are located adjacent to one another on mouse chromosome 7. Thus, the roles of these UCPs in both metabolic efficiency and the linkage to obesity and diabetes syndromes is unclear. For this reason, we examined the expression of UCP2 and UCP3 in white adipose tissue and interscapular brown adipose tissue and in gastrocnemius/soleus muscle preparations from the obesity-resistant A/J and C57BL/KsJ (KsJ) strains and the obesity-prone C57BL/6J (B6) mouse strain. In both KsJ and A/J mice, UCP2 expression in white fat was increased approximately 2-fold in response to 2 weeks of a high fat diet, but there was no effect of diet on UCP2 levels in B6 mice. In skeletal muscle and in brown fat, neither UCP2 nor UCP3 expression was affected by diet in A/J, B6, or KsJ mice. However, in brown fat, we observed a 2-3-fold increase in the expression of UCP1 in response to dietary fat challenge, which may be related to diet-induced elevations in plasma leptin levels. Together, these results indicate that the consumption of a high fat diet selectively regulates UCP2 expression in white fat and UCP1 expression in brown fat and that resistance to obesity is correlated with this early, selective induction of UCP1 and UCP2 and is not associated with changes in expression of UCP3.}, Doi = {10.1073/pnas.95.7.4061}, Key = {fds276437} } @article{fds305786, Author = {Surwit, RS}, Title = {Sucrose in weight-loss regimens - Reply}, Journal = {American Journal of Clinical Nutrition}, Volume = {67}, Number = {1}, Pages = {151-151}, Publisher = {AMER SOC CLINICAL NUTRITION}, Year = {1998}, Month = {January}, ISSN = {0002-9165}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000071362100030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305786} } @article{fds319714, Author = {SURWIT, RS}, Title = {Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice}, Journal = {Proc. Natl. Acad. Sci. Usa}, Volume = {95}, Number = {7}, Pages = {4061-4065}, Year = {1998}, ISSN = {0027-8424}, Keywords = {Adipose Tissue • Animals • Carrier Proteins • Chromosome Mapping • Diet* • Gene Expression Regulation • Ion Channels • Male • Membrane Transport Proteins* • Mice • Mitochondrial Proteins* • Molecular Sequence Data • Obesity • Protein Biosynthesis* • Proteins • biosynthesis* • genetics • metabolism*}, Abstract = {Uncoupling protein 2 (UCP2) maps to a region on distal mouse chromosome 7 that has been linked to the phenotypes of obesity and type II diabetes. We recently reported that UCP2 expression is increased by high fat feeding in adipose tissue of the A/J strain of mice, which is resistant to the development of dietary obesity. More recently, a third UCP (UCP3) was identified, which is expressed largely in skeletal muscle and brown adipose tissue. The UCP2 and UCP3 genes are located adjacent to one another on mouse chromosome 7. Thus, the roles of these UCPs in both metabolic efficiency and the linkage to obesity and diabetes syndromes is unclear. For this reason, we examined the expression of UCP2 and UCP3 in white adipose tissue and interscapular brown adipose tissue and in gastrocnemius/soleus muscle preparations from the obesity-resistant A/J and C57BL/KsJ (KsJ) strains and the obesity-prone C57BL/6J (B6) mouse strain. In both KsJ and A/J mice, UCP2 expression in white fat was increased approximately 2-fold in response to 2 weeks of a high fat diet, but there was no effect of diet on UCP2 levels in B6 mice. In skeletal muscle and in brown fat, neither UCP2 nor UCP3 expression was affected by diet in A/J, B6, or KsJ mice. However, in brown fat, we observed a 2-3-fold increase in the expression of UCP1 in response to dietary fat challenge, which may be related to diet-induced elevations in plasma leptin levels. Together, these results indicate that the consumption of a high fat diet selectively regulates UCP2 expression in white fat and UCP1 expression in brown fat and that resistance to obesity is correlated with this early, selective induction of UCP1 and UCP2 and is not associated with changes in expression of UCP3.}, Key = {fds319714} } @article{fds141657, Author = {RS Surwit and AE Petro and P Parekh and S Collins}, Title = {Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice.}, Journal = {Diabetes, UNITED STATES}, Volume = {46}, Number = {9}, Pages = {1516-20}, Year = {1997}, Month = {September}, ISSN = {0012-1797}, Keywords = {Animals • Body Temperature • Body Weight • Diabetes Mellitus, Experimental • Dietary Fats • Ion Channels • Leptin • Membrane Transport Proteins* • Mice • Mice, Inbred A • Mice, Inbred C57BL • Mice, Inbred Strains • Mitochondrial Proteins* • Obesity • Proteins • Time Factors • genetics • metabolism* • physiopathology*}, Abstract = {Despite the fact that mutations resulting in the absence of leptin or its receptor have been associated with severe obesity and diabetes, such mutations do not appear to be responsible for most human obesity. Indeed, diet-induced obesity in animals and humans has been characterized by hyperleptinemia. This has been interpreted as evidence for leptin resistance. However, no careful longitudinal studies evaluating the role of leptin in the development of obesity exist. We report a series of studies in A/J and C57BL/6J (B/6) mice that demonstrate a direct relationship between the ability to increase plasma leptin levels in response to a high-fat diet and resistance to the subsequent development of obesity and diabetes. While leptin levels are similar in lean, low-fat-fed A/J and B/6 mice, the effects of a high-fat diet on plasma leptin differ dramatically between the two strains. After 4 weeks of high-fat feeding, leptin levels in A/J mice increased 10-fold, and this elevated level was maintained independent of weight gain throughout a 14-week feeding period. However, in B/6 mice, leptin levels remained at least twofold lower and only rose very gradually along with a significant increase in adiposity, hyperglycemia, and hyperinsulinemia. These differences in the response of leptin to diet are independent of food intake and plasma insulin levels during the 1st month of feeding. Further, we demonstrated that leptin administration did not influence the expression of the novel uncoupling protein UCP2, which also responds to dietary fat. From these results, we suggest that the response of leptin to fat feeding may be an important predictor of the development of subsequent obesity.}, Key = {fds141657} } @article{fds276438, Author = {R.S. Surwit and Surwit, RS and Petro, AE and Parekh, P and Collins, S}, Title = {Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice.}, Journal = {Diabetes}, Volume = {46}, Number = {9}, Pages = {1516-1520}, Year = {1997}, Month = {September}, ISSN = {0012-1797}, url = {http://www.ncbi.nlm.nih.gov/pubmed/9287057}, Abstract = {Despite the fact that mutations resulting in the absence of leptin or its receptor have been associated with severe obesity and diabetes, such mutations do not appear to be responsible for most human obesity. Indeed, diet-induced obesity in animals and humans has been characterized by hyperleptinemia. This has been interpreted as evidence for leptin resistance. However, no careful longitudinal studies evaluating the role of leptin in the development of obesity exist. We report a series of studies in A/J and C57BL/6J (B/6) mice that demonstrate a direct relationship between the ability to increase plasma leptin levels in response to a high-fat diet and resistance to the subsequent development of obesity and diabetes. While leptin levels are similar in lean, low-fat-fed A/J and B/6 mice, the effects of a high-fat diet on plasma leptin differ dramatically between the two strains. After 4 weeks of high-fat feeding, leptin levels in A/J mice increased 10-fold, and this elevated level was maintained independent of weight gain throughout a 14-week feeding period. However, in B/6 mice, leptin levels remained at least twofold lower and only rose very gradually along with a significant increase in adiposity, hyperglycemia, and hyperinsulinemia. These differences in the response of leptin to diet are independent of food intake and plasma insulin levels during the 1st month of feeding. Further, we demonstrated that leptin administration did not influence the expression of the novel uncoupling protein UCP2, which also responds to dietary fat. From these results, we suggest that the response of leptin to fat feeding may be an important predictor of the development of subsequent obesity.}, Doi = {10.2337/diab.46.9.1516}, Key = {fds276438} } @article{fds141639, Author = {RS Surwit and MN Feinglos and CC McCaskill and SL Clay and MA Babyak and BS Brownlow, CS Plaisted and PH Lin}, Title = {Metabolic and behavioral effects of a high-sucrose diet during weight loss.}, Journal = {The American journal of clinical nutrition, UNITED STATES}, Volume = {65}, Number = {4}, Pages = {908-15}, Year = {1997}, Month = {April}, ISSN = {0002-9165}, Keywords = {Adult • Analysis of Variance • Behavior • Blood Glucose • Blood Pressure • Body Composition • Body Mass Index • Body Weight • Cholesterol • Diet, Fat-Restricted • Dietary Sucrose • Energy Metabolism • Epinephrine • Female • Humans • Lipids • Middle Aged • Thyrotropin • Thyroxine • Triiodothyronine • Weight Loss • analysis • blood • drug effects • pharmacology* • physiology • physiology*}, Abstract = {In response to evidence linking obesity and high amounts of dietary fat, the food industry has developed numerous reduced-fat and nonfat food items. These items frequently derive a relatively large percentage of their energy from sugars and the effect of these sugars on weight regulation is not well known. We studied the comparative effects of high- and low-sucrose, low-fat, hypoenergetic diets on a variety of metabolic and behavioral indexes in a 6-wk weight-loss program. Both diets contained approximately 4606 kJ energy/d with 11% of energy as fat, 19% as protein, and 71% as carbohydrate. The high-sucrose diet contained 43% of the total daily energy intake as sucrose; the low-sucrose diet contained 4% of the total daily energy intake as sucrose. Twenty women aged 40.6 +/- 8.2 y (mean +/- SD) with a body mass index (in kg/m2) of 35.93 +/- 4.8 consumed the high-sucrose diet; 22 women aged 40.3 +/- 7.3 y with a body mass index of 34.93 +/- 4.4 consumed the low-sucrose diet. Mixed-design analysis of variance showed a main effect of time (P < 0.01), with both diet groups showing decreases in weight, blood pressure, resting energy expenditure, percentage body fat, free triiodothyronine (FT3), urinary norepinephrine, and plasma lipids. Small but significant interactions were found between group and time in total cholesterol (P = 0.009) and low-density lipoprotein (LDL) (P = 0.01). Both groups showed decreases in depression, hunger, and negative mood, and increases in vigilance and positive mood with time (P < 0.01). Results showed that a high sucrose content in a hypoenergetic, low-fat diet did not adversely affect weight loss, metabolism, plasma lipids, or emotional affect.}, Key = {fds141639} } @article{fds276440, Author = {R.S. Surwit and Surwit, RS and Feinglos, MN and McCaskill, CC and Clay, SL and Babyak, MA and Brownlow, BS and Plaisted, CS and Lin, PH}, Title = {Metabolic and behavioral effects of a high-sucrose diet during weight loss.}, Journal = {American Journal of Clinical Nutrition}, Volume = {65}, Number = {4}, Pages = {908-915}, Year = {1997}, Month = {April}, ISSN = {0002-9165}, url = {http://www.ncbi.nlm.nih.gov/pubmed/9094871}, Abstract = {In response to evidence linking obesity and high amounts of dietary fat, the food industry has developed numerous reduced-fat and nonfat food items. These items frequently derive a relatively large percentage of their energy from sugars and the effect of these sugars on weight regulation is not well known. We studied the comparative effects of high- and low-sucrose, low-fat, hypoenergetic diets on a variety of metabolic and behavioral indexes in a 6-wk weight-loss program. Both diets contained approximately 4606 kJ energy/d with 11% of energy as fat, 19% as protein, and 71% as carbohydrate. The high-sucrose diet contained 43% of the total daily energy intake as sucrose; the low-sucrose diet contained 4% of the total daily energy intake as sucrose. Twenty women aged 40.6 +/- 8.2 y (mean +/- SD) with a body mass index (in kg/m2) of 35.93 +/- 4.8 consumed the high-sucrose diet; 22 women aged 40.3 +/- 7.3 y with a body mass index of 34.93 +/- 4.4 consumed the low-sucrose diet. Mixed-design analysis of variance showed a main effect of time (P < 0.01), with both diet groups showing decreases in weight, blood pressure, resting energy expenditure, percentage body fat, free triiodothyronine (FT3), urinary norepinephrine, and plasma lipids. Small but significant interactions were found between group and time in total cholesterol (P = 0.009) and low-density lipoprotein (LDL) (P = 0.01). Both groups showed decreases in depression, hunger, and negative mood, and increases in vigilance and positive mood with time (P < 0.01). Results showed that a high sucrose content in a hypoenergetic, low-fat diet did not adversely affect weight loss, metabolism, plasma lipids, or emotional affect.}, Doi = {10.1093/ajcn/65.4.908}, Key = {fds276440} } @article{fds276357, Author = {Fleury, C and Neverova, M and Collins, S and Raimbault, S and Champigny, O and Levi-Meyrueis, C and Bouillaud, F and Seldin, MF and Surwit, RS and Ricquier, D and Warden, CH}, Title = {Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia.}, Journal = {Nature Genetics}, Volume = {15}, Number = {3}, Pages = {269-272}, Year = {1997}, Month = {March}, ISSN = {1061-4036}, url = {http://www.ncbi.nlm.nih.gov/pubmed/9054939}, Keywords = {Adipose Tissue • Adipose Tissue, Brown • Adult • Animals • Base Sequence • Carrier Proteins • Chromosome Mapping* • Chromosomes, Human, Pair 11* • DNA Primers • Diabetes Mellitus • Humans • Hyperinsulinism • Ion Channels • Membrane Proteins • Membrane Transport Proteins* • Mice • Mitochondrial Proteins* • Models, Biological • Molecular Sequence Data • Obesity • Organ Specificity • Polymerase Chain Reaction • Proteins* • Up-Regulation • biosynthesis • genetics • genetics* • metabolism • metabolism*}, Abstract = {A mitochondrial protein called uncoupling protein (UCP1) plays an important role in generating heat and burning calories by creating a pathway that allows dissipation of the proton electrochemical gradient across the inner mitochondrial membrane in brown adipose tissue, without coupling to any other energy-consuming process. This pathway has been implicated in the regulation of body temperature, body composition and glucose metabolism. However, UCP1-containing brown adipose tissue is unlikely to be involved in weight regulation in adult large-size animals and humans living in a thermoneutral environment (one where an animal does not have to increase oxygen consumption or energy expenditure to lose or gain heat to maintain body temperature), as there is little brown adipose tissue present. We now report the discovery of a gene that codes for a novel uncoupling protein, designated UCP2, which has 59% amino-acid identity to UCP1, and describe properties consistent with a role in diabetes and obesity. In comparison with UCP1, UCP2 has a greater effect on mitochondrial membrane potential when expressed in yeast. Compared to UCP1, the gene is widely expressed in adult human tissues, including tissues rich in macrophages, and it is upregulated in white fat in response to fat feeding. Finally, UCP2 maps to regions of human chromosome 11 and mouse chromosome 7 that have been linked to hyperinsulinaemia and obesity. Our findings suggest that UCP2 has a unique role in energy balance, body weight regulation and thermoregulation and their responses to inflammatory stimuli.}, Doi = {10.1038/ng0397-269}, Key = {fds276357} } @article{fds276316, Author = {Surwit, R and Petro, AE and Parekh, P and Collins, S}, Title = {Erratum: Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice (Diabetes (1997) 46 (1516-1520))}, Journal = {Diabetes}, Volume = {46}, Number = {11}, Pages = {1920}, Year = {1997}, Month = {January}, Key = {fds276316} } @article{fds276407, Author = {Collins, S and Daniel, KW and Petro, AE and Surwit, RS}, Title = {Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice.}, Journal = {Endocrinology}, Volume = {138}, Number = {1}, Pages = {405-413}, Year = {1997}, Month = {January}, ISSN = {0013-7227}, url = {http://www.ncbi.nlm.nih.gov/pubmed/8977430}, Keywords = {Adipocytes • Adrenergic beta-Agonists • Animals • Blood Glucose • Carrier Proteins • Dietary Fats • Insulin • Ion Channels • Male • Membrane Proteins • Mice • Mitochondrial Proteins • Obesity • RNA, Messenger • Receptors, Adrenergic, beta • Receptors, Adrenergic, beta-3 • Species Specificity • adverse effects* • analysis • blood • genetics • pharmacology* • physiology* • physiopathology*}, Abstract = {Fat intake has long been associated with the development of obesity. The studies described herein show that fat adversely affects adipocyte adrenergic receptor (AR) expression and function. As beta 3AR agonists have been shown to acutely reduce adipose tissue mass and improve thermogenesis in genetically obese rodents, we examined whether chronic supplementation of a high fat diet with a highly selective beta 3AR agonist, CL316,243 could prevent diet-induced obesity, and whether the effect could be sustained over prolonged treatment. C57BL/6J and A/J mice were weaned onto one of three diets: low fat (10.5% calories from fat), high fat (58% calories from fat), or high fat supplemented with 0.001% CL316,243. B/6J mice gained more weight on the high fat diet than A/J mice (at 16 weeks: B/6J, 36.6 +/- 1.4 g; A/J, 32.9 +/- 0.8 g; P < 0.002; n = 10), whereas weights on the low fat diets were similar (B/6J, 29.5 +/- 0.5 g; A/J, 28.8 +/- 0.6 g; P > 0.05; n = 10). CL316,243 prevented the development of diet-induced obesity in A/J animals, but not in B/6J animals. A/J mice weighed 26.0 +/- 0.5 g at 16 weeks, whereas B/6J animals on the same diet weighed 34.1 +/- 0.8 g (P < 0.00001; n = 10), but food intake was not different between the strains throughout the study. beta-Adrenergic stimulation of adenylyl cyclase in obese B/6J mice was decreased by more than 75% in white adipose tissue and by more than 90% in brown adipose tissue (BAT). In contrast, in fat-fed A/J mice, beta-agonist-stimulated adenylyl cyclase was decreased in white adipose tissue by about 10%, whereas the activity in interscapular BAT was decreased by 50%, indicating significant retention of beta AR-stimulated activity in A/J mice compared to B/6J mice. High fat feeding was associated with decreased expression of beta 3AR and beta 1AR in white adipose tissue of both strains. However, chronic CL316,243 treatment prevented both the obesity and the decline in beta 3AR and beta 1AR messenger RNA levels in all adipose depots from A/J mice, but not B/6J mice. As CL316,243-treated A/J mice, but not B/6J mice, also showed marked uncoupling protein expression in white adipose depots, the ability of chronic CL316,243 treatment to prevent diet-induced obesity is dependent upon the elaboration of functional BAT in these regions.}, Doi = {10.1210/endo.138.1.4829}, Key = {fds276407} } @article{fds141566, Title = {Surwit RS, Petro AE, Parekh P, Collins S: Low plasma leptin in response to dietary fat in diabetes and obesity prone mice. Diabetes 46: 1516-1520, 1997.}, Year = {1997}, Key = {fds141566} } @article{fds141606, Title = {Fleury C, Neverova M, Collins S, Raimbault S, Champign O, Levi Meyrueis C, Bouillaud F, Seldin MF, Surwit RS, ricquier D, Warden CH: Uncoupling protein-2: A novel candidate thermogenic protein linked to obesity and insulin resistance. Nature Genetics 15: 269-272, 1997.}, Year = {1997}, Key = {fds141606} } @article{fds141615, Title = {Collins S, Daniel KW, Petro AE, Surwit RS: Strain-specific response to B3 AR agonist treatment of diet-induced obesity in mice. Endocrinology 138: 405-413, 1997.}, Year = {1997}, Key = {fds141615} } @article{fds141616, Title = {Surwit RS, Feinglos MN, McCaskill CC, Clay SL, Babyak MA, Brownlow BS, Plaisted CG, Lin PH: Metabolic and behavioral effects of a high sucrose diet in weight loss. American Journal Clinical Nutrition 65: 908-915, 1997.}, Year = {1997}, Key = {fds141616} } @article{fds141617, Title = {Fleury C, Neverova M, Collins S, Raimbault S, Champign O, Levi-Meyrueis C, Bouillaud F, Seldin MF, Surwit RS, Ricquier D, Warden CH: Uncompling protein-2: A novel candidate thermogenic protein linked to obesity and insulin resistance. Nature Genetics 15: 269-272, 1997.}, Year = {1997}, Key = {fds141617} } @article{fds276439, Author = {R.S. Surwit and Fleury, C and Neverova, M and Collins, S and Raimbault, S and Champign, O and Levi Meyrueis and C and Bouillaud, F and Seldin, MF and Ricquier, D and Warden, CH}, Title = {Uncoupling protein-2: A novel candidate thermogenic protein linked to obesity and insulin resistance}, Journal = {Nature Genetics}, Volume = {15}, Pages = {269-272}, Year = {1997}, Key = {fds276439} } @article{fds141579, Author = {BS Brownlow and A Petro and MN Feinglos and RS Surwit}, Title = {The role of motor activity in diet-induced obesity in C57BL/6J mice.}, Journal = {Physiology & behavior, UNITED STATES}, Volume = {60}, Number = {1}, Pages = {37-41}, Year = {1996}, Month = {July}, ISSN = {0031-9384}, Keywords = {Animals • Blood Glucose • Dietary Fats • Energy Intake • Insulin • Male • Mice • Mice, Inbred A • Mice, Inbred C57BL • Mice, Obese • Motor Activity • Obesity • Species Specificity • Weight Gain • administration & dosage* • blood • genetics • genetics* • metabolism • physiology}, Abstract = {Previous research in our laboratory has demonstrated that the C57BL/6J (B/6J) mouse has a predisposition to develop severe obesity if placed on a high-fat diet. In the present study we assessed the role of physical activity in this phenomenon. Obesity-prone B/6J and obesity-resistant A/J mice were placed on one of four diets; high fat/high sucrose, high fat/low sucrose, low fat/high sucrose, and low fat/low sucrose. After 4 months, all animals on the high-fat diets had gained more weight than animals on the low-fat diets, and this phenomenon was greatly exaggerated in B/6J mice. Despite the fact that B/6J mice gained more weight than A/J mice on high-fat diets without consuming more calories, spontaneous motor activity was elevated in B/6J mice compared to A/J mice. There was no effect of the diets on activity either within or across strains. These data suggest that predisposition to diet-induced obesity is not explainable by reduced levels of physical activity.}, Key = {fds141579} } @article{fds276442, Author = {R.S. Surwit and Brownlow, BS and Petro, A and Feinglos, MN and Surwit, RS}, Title = {The role of motor activity in diet-induced obesity in C57BL/6J mice.}, Journal = {Physiology & Behavior}, Volume = {60}, Number = {1}, Pages = {37-41}, Year = {1996}, Month = {July}, ISSN = {0031-9384}, url = {http://www.ncbi.nlm.nih.gov/pubmed/8804640}, Abstract = {Previous research in our laboratory has demonstrated that the C57BL/6J (B/6J) mouse has a predisposition to develop severe obesity if placed on a high-fat diet. In the present study we assessed the role of physical activity in this phenomenon. Obesity-prone B/6J and obesity-resistant A/J mice were placed on one of four diets; high fat/high sucrose, high fat/low sucrose, low fat/high sucrose, and low fat/low sucrose. After 4 months, all animals on the high-fat diets had gained more weight than animals on the low-fat diets, and this phenomenon was greatly exaggerated in B/6J mice. Despite the fact that B/6J mice gained more weight than A/J mice on high-fat diets without consuming more calories, spontaneous motor activity was elevated in B/6J mice compared to A/J mice. There was no effect of the diets on activity either within or across strains. These data suggest that predisposition to diet-induced obesity is not explainable by reduced levels of physical activity.}, Doi = {10.1016/0031-9384(95)02210-4}, Key = {fds276442} } @article{fds276372, Author = {Collins, S and Kuhn, CM and Petro, AE and Swick, AG and Chrunyk, BA and Surwit, RS}, Title = {Role of leptin in fat regulation.}, Journal = {Nature}, Volume = {380}, Number = {6576}, Pages = {677}, Year = {1996}, Month = {April}, ISSN = {0028-0836}, url = {http://www.ncbi.nlm.nih.gov/pubmed/8614460}, Keywords = {Adipose Tissue • Adipose Tissue, Brown • Animals • Body Temperature Regulation • Body Weight • Catecholamines • Eating • Enzyme Inhibitors • Female • Leptin • Methyltyrosines • Mice • Mice, Inbred C57BL • Norepinephrine • Obesity • Proteins • Sympathetic Nervous System • Tyrosine 3-Monooxygenase • alpha-Methyltyrosine • antagonists & inhibitors • etiology • metabolism • pharmacology • physiology • physiology*}, Doi = {10.1038/380677a0}, Key = {fds276372} } @article{fds276423, Author = {Collins, S and Surwit, RS}, Title = {Pharmacologic manipulation of ob expression in a dietary model of obesity.}, Journal = {The Journal of Biological Chemistry}, Volume = {271}, Number = {16}, Pages = {9437-9440}, Year = {1996}, Month = {April}, ISSN = {0021-9258}, url = {http://www.ncbi.nlm.nih.gov/pubmed/8621612}, Keywords = {Adipose Tissue • Adipose Tissue, Brown • Adrenergic beta-Agonists • Animals • Base Sequence • Blotting, Northern • DNA Primers • Dietary Fats • Dioxoles • Energy Intake • Gene Expression* • Leptin • Male • Mice • Mice, Inbred A • Mice, Inbred C57BL • Mice, Obese • Molecular Sequence Data • Obesity • Organ Specificity • Polymerase Chain Reaction • Protein Biosynthesis* • Proteins • RNA, Messenger • Species Specificity • biosynthesis • drug effects • genetics • genetics* • pharmacology • physiopathology*}, Abstract = {Mutation of the obese (ob) gene results in severe hereditary obesity and diabetes in the C57BL/6J and related strains of mice. In this study we examined the expression of the ob gene in a dietary model in which moderate obesity develops in response to fat (58% of calories from fat) without mutation of the ob gene, and in four genetic models of obesity in mice: ob/ob, db/db, tubby, and fat. Several white and brown adipose depots were examined (epididymal, subcutaneous, perirenal, and interscapular). Northern blot analysis shows that levels of ob mRNA are increased in all adipose depots examined in every model of obesity. The average fold increases were 12.0 +/ 2.1 (ob/ob), 4.8 +/- 1.5 (db/db), 2.8 +/- 0.1 (tubby), 2.4 +/- 0.3 (fat), and 2.1 +/- 0.2 (high fat diet-induced A/J). Moreover, we found that the expression of the ob gene could be manipulated by pharmacologically blocking the development of diet-induced obesity. Supplementation of a high fat diet with a beta 3-adrenergic receptor agonist (CL316,243) prevented obesity, but not hyperphagia associated with high fat feeding (body weights of high fat-fed A/J mice = 34.0 +/- 1.0 g; high fat plus CL316,243-fed mice = 26.8 +/- 0.5 g; n = 10). CL316,243-treated, high fat-fed animals contained levels of ob mRNA in all adipose depots that were equal to or less than levels in low fat-fed mice (average levels in high fat plus CL316,243-fed mice relative to low fat-fed mice: 0.93 +/- 0.09). Inasmuch as fat cell size, but not number, was increased in a previous study in diet-induced obese A/J mice, these results indicate that expression of the ob gene serves as a sensor of fat cell hypertrophy, independent of any effects on food intake.}, Doi = {10.1074/jbc.271.16.9437}, Key = {fds276423} } @article{fds276361, Author = {Opara, EC and Petro, A and Tevrizian, A and Feinglos, MN and Surwit, RS}, Title = {L-glutamine supplementation of a high fat diet reduces body weight and attenuates hyperglycemia and hyperinsulinemia in C57BL/6J mice.}, Journal = {The Journal of Nutrition}, Volume = {126}, Number = {1}, Pages = {273-279}, Year = {1996}, Month = {January}, ISSN = {0022-3166}, url = {http://www.ncbi.nlm.nih.gov/pubmed/8558312}, Keywords = {Animals • Blood Glucose • Body Weight • Dietary Carbohydrates • Dietary Fats • Eating • Fatty Acids • Food, Fortified • Glutamine • Hyperglycemia • Hyperinsulinism • Insulin • Insulin Resistance • Lipids • Male • Mice • Mice, Inbred C57BL • Obesity • Oxidation-Reduction • administration & dosage • administration & dosage* • analysis • blood • diet therapy* • drug effects • metabolism • pharmacology • pharmacology* • physiology • physiopathology • standards}, Abstract = {C57BL/6J (B/6J) mice are genetically predisposed to become overweight and develop hyperglycemia if raised on a high fat diet. The purpose of the present study was to explore the effect of dietary supplementation of L-glutamine (Gln), an inhibitor of fatty acid oxidation, on the development of hyperglycemia and excessive weight gain. Groups of 10 age- and weight-matched male B/6J mice were raised on one of four diets: 1) a low fat, low sucrose (LL), studied separately, 2) a high fat, low sucrose (HL) diet alone, 3) high fat, low sucrose supplemented with L-glutamine (HL+Gln) and 4) high fat, low sucrose supplemented with L-alanine (HL+Ala). Energy intake, body weight, plasma glucose and insulin concentrations were monitored over time. We found no difference in energy intake per unit body weight between any groups after the first 2 wk of feeding. However, the mean +/- SEM for body weight (27.1 +/- 0.6 g) of the LL group measured at 16 wk was lower (P < 0.05) than that of the HL group at 37.9 +/- 1.9 g. Also, after 5.5 mo, the mean +/- SEM for plasma glucose and insulin concentrations in the LL group of mice were 6.9 +/- 0.4 mmol/l and 146 +/- 30 pmol/l, which were lower (P < 0.05) than those in the HL group at 10.1 +/- 0.9 mmol/l and 438 +/- 84 pmol/l, respectively. Although both amino acids caused a 10% reduction (P < 0.05) in body weight compared with HL feeding at wk 16, only Gln supplementation resulted in persistent reductions in both plasma glucose and insulin concentrations over 5.5 mo. In another experiment, when Gln was added to the high fat (HL) diet of heavy hyperglycemic animals for 2 mo, body weight gain, hyperglycemia and hyperinsulinemia were attenuated. In conclusion, supplementing glutamine to a high fat diet reduces body weight and attenuated hyperglycemia and hyperinsulinemia in B/6J mice.}, Doi = {10.1093/jn/126.1.273}, Key = {fds276361} } @article{fds141559, Title = {Collins S, Kuhn CM, Petro AE, Swick AG, Chruny BA, Surwit RS: Role of leptin in fat regulation. Nature 360: 677, 1996.}, Year = {1996}, Key = {fds141559} } @article{fds141564, Title = {Collins S, Kuhn CM, Petro AE, Swick AG, Chruny BA, Surwit RS: Role of leptin in fat regulation Nature 380: 677, 1996.}, Year = {1996}, Key = {fds141564} } @article{fds141565, Title = {Surwit RS, Williams P: Animal models provide insight into psychosomatic factors in diabetes. Psychosomatic Medicine 58: 582-589, 1996.}, Year = {1996}, Key = {fds141565} } @article{fds141604, Title = {Collins S, Surwit RS: Pharmacologic manipulation of ob expression in a dietary model of obesity. Journal of Biological Chemistry 271: 9437-9440, 1996.}, Year = {1996}, Key = {fds141604} } @article{fds141605, Title = {Brownlow BS, Petro A, Feinglos MN, Surwit RS: The role of motor activity in diet-induced obesity in C57BL/6J mice. Physiology and Behavior 60: 37-41, 1996.}, Year = {1996}, Key = {fds141605} } @article{fds141614, Title = {Opara EC, Petro AE, Tevrizian A, Feinglos MN, Surwit RS: Metabolic efficacy of L-glutamine supplementation during high fat feeding in the C57BL/6J mouse. the Journal of Nutrition 126: 273-279, 1996.}, Year = {1996}, Key = {fds141614} } @article{fds276382, Author = {Surwit, RS and Williams, PG}, Title = {Animal models provide insight into psychosomatic factors in diabetes.}, Journal = {Psychosomatic Medicine}, Volume = {58}, Number = {6}, Pages = {582-589}, Year = {1996}, ISSN = {0033-3174}, url = {http://www.ncbi.nlm.nih.gov/pubmed/8948006}, Keywords = {Animals • Diabetes Mellitus • Disease Models, Animal* • Disease Susceptibility • Humans • Hyperphagia • Mice • Mice, Inbred Strains • Obesity • Psychophysiologic Disorders* • Stress • physiopathology • psychology • psychology*}, Abstract = {OBJECTIVE: To review the literature regarding the use of animal models in research addressing psychosomatic aspects of diabetes. METHOD: We examine the key findings in animal model vs. human research in the area of stress and diabetes. Previous research has suggested that stress is a potential contributor to chronic hyperglycemia in diabetes. Stress affects metabolic activity via the stimulation of a variety of hormones that can result in elevated blood glucose levels. In patients with diabetes, due to a relative or absolute lack of insulin, stress-induced increases in glucose cannot be properly metabolized. Additionally, regulation of these stress hormones may be abnormal in diabetes. RESULTS: Human studies on the role of stress in the onset and course of type II diabetes are few and are limited by the constraints and logistics of examining life stress in humans. However, animal research allows for tight experimental control and the manipulation of factors that may contribute to the development and/or course of diabetes, such as stress, eating behavior, the nutrient content of food, and physical activity. Disease processes can be examined at a mechanistic level in animals which is typically limited in human research. CONCLUSIONS: There is a large body of animal work to support the notion that stress reliably produces hyperglycemia in type II diabetes. Furthermore, there is evidence that the autonomic nervous system plays a role in the pathophysiology of this condition in both animals and humans. Examination of eating behavior and nutrient content of food in animal models of diabetes has shed light on the role of these factors in the development of diabetes, as well as obesity. Finally, genetic research using animal models of diabetes will provide new directions for research in humans to delineate the genetic contribution to the development of diabetes.}, Doi = {10.1097/00006842-199611000-00006}, Key = {fds276382} } @article{fds276417, Author = {Lee, SK and Opara, EC and Surwit, RS and Feinglos, MN and Akwari, OE}, Title = {Defective glucose-stimulated insulin release from perifused islets of C57BL/6J mice.}, Journal = {Pancreas}, Volume = {11}, Number = {2}, Pages = {206-211}, Year = {1995}, Month = {August}, ISSN = {0885-3177}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7479681}, Keywords = {Animals • Blood Glucose • Diabetes Mellitus, Experimental • Diabetes Mellitus, Type 2 • Dietary Carbohydrates • Dietary Fats • Glucose • Insulin • Islets of Langerhans • Lauric Acids • Male • Mice • Mice, Inbred C57BL • Perfusion • administration & dosage • drug effects • etiology • metabolism • pathology • pharmacology • pharmacology* • secretion*}, Abstract = {Previous work has shown that the C57BL/6J (BL/6) mouse strain develops type 2 diabetes after being fed a high-fat, high-simple carbohydrate (HFHSC) diet. In contrast, the AJ mouse strain does not. The aim of the present study was to determine if differences in the insulin secretory characteristics of isolated perifused islets of these animals could help explain why the BL/6 mouse develops diet-induced diabetes. Insulin secretion was assessed as mean integrated area under the curve during 20 min of stimulation with 27.7 mM glucose or 5 mM lauric acid. We found that both glucose- and laurate-stimulated insulin secretions were significantly less in euglycemic BL/6 mice than in the euglycemic AJ mice. The defect in insulin response to glucose, but not laurate, in islets from the BL/6 mouse was exacerbated when the animals were fed the HFHSC diet. These data suggest that the BL/6 mouse has a defective insulin response to glucose, which is exacerbated by a diabetogenic diet.}, Doi = {10.1097/00006676-199508000-00016}, Key = {fds276417} } @article{fds276351, Author = {Wencel, HE and Smothers, C and Opara, EC and Kuhn, CM and Feinglos, MN and Surwit, RS}, Title = {Impaired second phase insulin response of diabetes-prone C57BL/6J mouse islets.}, Journal = {Physiology & Behavior}, Volume = {57}, Number = {6}, Pages = {1215-1220}, Year = {1995}, Month = {June}, ISSN = {0031-9384}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7652047}, Keywords = {Animals • Diabetes Mellitus, Type 2 • Diet • Dietary Carbohydrates • Dietary Fats • Glucose • Insulin • Islets of Langerhans • Male • Mice • Mice, Inbred C57BL • Mice, Inbred Strains • Stimulation, Chemical • genetics • pharmacology • physiopathology* • secretion*}, Abstract = {The C57BL/6J mouse develops obesity and diabetes in response to a high-fat, high-simple carbohydrate diet. To determine the dynamics of glucose-induced insulin release in this animal model of NIDDM, we studied the acute insulin response to glucose of perifused islets in C57BL/6J (diabetes-prone) and A/J (diabetes-resistant) mice fed a normal control diet and of others fed a diabetogenic diet. The insulin response of normal C57BL/6J islets was almost monophasic, with a deficiency in the second phase during high glucose stimulation when compared to that of A/J control islets. The defect in C57BL/6J mice was exaggerated in animals fed a diabetogenic diet. It is suggested that a latent deficiency of second phase insulin release may contribute to the development of the diet-induced syndrome in this model.}, Doi = {10.1016/0031-9384(95)00022-b}, Key = {fds276351} } @article{fds276374, Author = {Gettys, TW and Ramkumar, V and Surwit, RS and Taylor, IL}, Title = {Tissue-specific alterations in G protein expression in genetic versus diet-induced models of non-insulin-dependent diabetes mellitus in the mouse.}, Journal = {Metabolism: Clinical and Experimental}, Volume = {44}, Number = {6}, Pages = {771-778}, Year = {1995}, Month = {June}, ISSN = {0026-0495}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7783662}, Keywords = {Adipose Tissue • Animals • Diabetes Mellitus, Type 2 • Diet* • GTP-Binding Proteins • Male • Mice • Mice, Inbred C57BL • Obesity • Reference Values • etiology • etiology* • genetics • genetics* • metabolism • metabolism*}, Abstract = {Various tissues were obtained from the well-characterized genetic model (C57BL/6J-ob/ob) of non-insulin-dependent diabetes mellitus (NIDDM) and from a diet-induced model of NIDDM produced in the same genetic background (C57BL/6J). The objectives were to determine whether the previously observed changes in guanine nucleotide-binding regulatory protein (G protein) expression in adipose tissue from ob/ob mice were mirrored by concomitant changes in other tissues, and whether NIDDM of a different etiology would share similar alterations in G protein expression. Plasma membranes from adipocytes, brain, heart, liver, and testes were probed with alpha-subunit-specific antisera, and the level of G protein expression in each model was compared with that in its lean littermate control. Adipose, heart, and liver cell membranes from ob/ob mice contained significantly less alpha-subunit of stimulatory G protein (Gs alpha) than those from their lean littermates. As compared with the lean littermates, heart alpha-subunit-2 of inhibitory G protein (Gi alpha-2), liver Gi alpha-3, and adipocyte G1 alpha-1 and Gi alpha-3 were also reduced in ob/ob mice. In contrast, Gi alpha-2 and Go alpha were increased over lean-control levels in brain tissue from ob/ob mice, whereas Gs alpha was unchanged. G protein expression in the testes did not differ between lean and ob/ob mice. In the diet-induced model of NIDDM, Gs alpha expression in the liver was twofold greater in obese/diabetic mice as compared with lean controls. However, G protein expression in all other tissues examined did not differ between obese/diabetic animals and lean littermates.(ABSTRACT TRUNCATED AT 250 WORDS)}, Doi = {10.1016/0026-0495(95)90191-4}, Key = {fds276374} } @article{fds276380, Author = {Edens, JL and Surwit, RS}, Title = {In support of behavioral treatment for day wetting in children.}, Journal = {Urology}, Volume = {45}, Number = {6}, Pages = {905-908}, Year = {1995}, Month = {June}, ISSN = {0090-4295}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7771021}, Keywords = {Behavior Therapy* • Child • Enuresis • Exercise Therapy • Humans • methods • therapy*}, Doi = {10.1016/s0090-4295(99)80106-x}, Key = {fds276380} } @article{fds276354, Author = {Surwit, RS and Feinglos, MN and Rodin, J and Sutherland, A and Petro, AE and Opara, EC and Kuhn, CM and Rebuffé-Scrive, M}, Title = {Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice.}, Journal = {Metabolism: Clinical and Experimental}, Volume = {44}, Number = {5}, Pages = {645-651}, Year = {1995}, Month = {May}, ISSN = {0026-0495}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7752914}, Keywords = {Adipose Tissue • Analysis of Variance • Animals • Blood Glucose • Body Weight • Diabetes Mellitus • Dietary Carbohydrates • Dietary Fats • Energy Intake • Hyperplasia • Insulin • Male • Mice • Mice, Inbred A • Mice, Inbred C57BL • Obesity* • Organ Size • Sucrose • Weight Gain • anatomy & histology • blood • metabolism • pathology • pharmacology* • physiopathology*}, Abstract = {We have previously demonstrated that the C57BL/6J (B/6J) mouse will develop severe obesity, hyperglycemia, and hyperinsulinemia if weaned onto a high-fat, high-sucrose (HH) diet. In the present study, we compared the effects of fat and sucrose separately and in combination on diabetes- and obesity-prone B/6J and diabetes- and obesity-resistant A/J mice. After 4 months, the feed efficiency ([FE] weight gained divided by calories consumed) did not differ across diets in A/J mice, but B/6J mice showed a significantly increased FE for fat. That is, B/6J mice gained more weight on high-fat diets without consuming more calories than A/J mice. The increase in FE was related to adipocyte hyperplasia in B/6J mice on high-fat diets. Fat-induced obesity in B/6J mice was unrelated to adrenal cortical activity. In the absence of fat, sucrose produced a decreased in FE in both strains. Animals fed a low-fat, high-sucrose (LH) diet were actually leaner than animals fed a high-complex-carbohydrate diet. Fat was also found to be the critical stimulus for hyperglycemia and hyperinsulinemia in B/6J mice. In the absence of fat, sucrose had no effect on plasma glucose or insulin. These data clearly show that across these two strains of mice, genetic differences in the metabolic response to fat are more important in the development of obesity and diabetes than the increased caloric content of a high-fat diet.}, Doi = {10.1016/0026-0495(95)90123-x}, Key = {fds276354} } @article{fds305796, Author = {OPARA, RC and PETRO, A and BROWN, S and FEINGLOS, MN and SURWIT, RS}, Title = {EFFECT OF VITAMIN-E SUPPLEMENTATION ON DIET-INDUCED DIABETES}, Journal = {Diabetes}, Volume = {44}, Pages = {A70-A70}, Publisher = {AMER DIABETES ASSOC}, Year = {1995}, Month = {May}, ISSN = {0012-1797}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995RA79600262&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305796} } @article{fds305801, Author = {OPARA, EC and PETRO, A and FEINGLOS, MN and SURWIT, RS}, Title = {PREVENTIVE AND THERAPEUTIC EFFECTS OF L-GLUTAMINE ON DIET-INDUCED DIABETES}, Journal = {Diabetes}, Volume = {44}, Pages = {A8-A8}, Publisher = {AMER DIABETES ASSOC}, Year = {1995}, Month = {May}, ISSN = {0012-1797}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995RA79600023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305801} } @article{fds305803, Author = {OPARA, EC and PETRO, A and TEVRIZIAN, A and FEINGLOS, MN and SURWIT, RS}, Title = {EFFECTS OF DIETARY-FAT REDUCTION AND L-GLUTAMINE SUPPLEMENTATION ON WEIGHT-GAIN}, Journal = {Gastroenterology}, Volume = {108}, Number = {4}, Pages = {A743-A743}, Publisher = {W B SAUNDERS CO}, Year = {1995}, Month = {April}, ISSN = {0016-5085}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995QT86302963&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305803} } @article{fds141562, Title = {Wencel HC, Smothers C, Opara E, Kuhn C, Feinglos M, Surwit RS: Impaired second phase insulin response of diabetes-prone C57BL/6J mouse islets. Physiology and Behavior 57: 1215-1220, 1995.}, Year = {1995}, Key = {fds141562} } @article{fds141563, Title = {Edens JL, Surwit RS: In support of behavioral treatment for day wetting in children. Urology 45: 904-907, 1995.}, Year = {1995}, Key = {fds141563} } @article{fds141603, Title = {Surwit RS, Feinglos MN, Rodin J, Sutherland A, Petro AE, Opara EC, Kuhn M: Rebuffe-Scrive. Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Metabolism 44: 645-651, 1995.}, Year = {1995}, Key = {fds141603} } @article{fds141611, Title = {Surwit RS, Feinglos MN, Rodin J, Sutherland A, Petro AE, Opara EC, Kuhn C, Rebuffe-Scrive M: Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Metabolism 44: 645-651, 1995.}, Year = {1995}, Key = {fds141611} } @article{fds141612, Title = {Gettys WT, Ramkumar V, Cochrane C, Surwit R, Taylor IL: Tissue specific alterations in G-protein expression in genetic vs diet-induced models of NIDDM in the mouse. Metabolism 44: 771-778, 1995.}, Year = {1995}, Key = {fds141612} } @article{fds141613, Title = {Lee SK, Opara EC, Surwit RS, Feinglos MN, Akwari OE: Defective glucose-stimulated insulin release from perifused islets of C57BL/6J mice. Pancreas 11: 206-211, 1995.}, Year = {1995}, Key = {fds141613} } @article{fds276384, Author = {Kuhn, CM and Surwit, RS and Feinglos, MN}, Title = {Glipizide stimulates sympathetic outflow in diabetes-prone mice.}, Journal = {Life Sciences}, Volume = {56}, Number = {9}, Pages = {661-666}, Year = {1995}, ISSN = {0024-3205}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7869847}, Keywords = {Animals • Diabetes Mellitus • Disease Susceptibility • Glipizide • Liver • Methyltyrosines • Mice • Mice, Inbred A • Mice, Inbred C57BL • Myocardium • Norepinephrine • Pancreas • drug effects • etiology* • metabolism • metabolism* • pharmacology • pharmacology*}, Abstract = {The purpose of the present study was to determine if the oral hypoglycemic agent glipizide influenced sympathetic outflow in diabetes-prone mice. C57BL/6 (diabetes-prone) and diabetes-resistant (A/J) were treated with saline or glipizide, and sympathetic outflow determined by the fall in organ norepinephrine content after synthesis inhibition with alpha-methyl-para-tyrosine. Sympathetic outflow to the liver and pancreas were slower in Bl/6 mice than in control A/J. Glipizide increased sympathetic outflow to the pancreas in both strains of mice, but did not influence outflow to other organs significantly. The results of this study suggest that glipizide can influence central glucoregulatory mechanisms after peripheral administration.}, Doi = {10.1016/0024-3205(94)00499-i}, Key = {fds276384} } @article{fds276363, Author = {Esposito-Del Puente and A and Lillioja, S and Bogardus, C and McCubbin, JA and Feinglos, MN and Kuhn, CM and Surwit, RS}, Title = {Glycemic response to stress is altered in euglycemic Pima Indians.}, Journal = {Int J Obes Relat Metab Disord}, Volume = {18}, Number = {11}, Pages = {766-770}, Year = {1994}, Month = {November}, ISSN = {0307-0565}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7866478}, Keywords = {Adolescent • Adult • Blood Glucose • Catecholamines • Diabetes Mellitus, Type 2 • European Continental Ancestry Group • Female • Glucagon • Glucose Tolerance Test • Humans • Hydrocortisone • Indians, North American • Insulin • Insulin Resistance • Male • Mathematics • Obesity • Prevalence • Radioimmunoassay • Risk Factors • Software • Stress, Psychological • analysis* • blood • blood* • complications • epidemiology • etiology • metabolism • physiopathology • psychology*}, Abstract = {The aim of this work was to study the effects of a computer-driven mental arithmetic task on blood glucose in a group of four male and four female euglycemic Caucasians and a group of seven male and six female euglycemic Pima Indians. Approximately 60% of euglycemic Pima Indian Native Americans eventually develop type 2 diabetes, while only 5% of Caucasians develop the disease. All subjects had normal glucose tolerance. Subjects were given a standard breakfast; 2 h later, they were given a computerized mental arithmetic stress test for 10 min. Before, during and after the test, several variables were analyzed, including serum concentrations of glucose, insulin, glucagon and plasma cortisol and catecholamines. Heart rate, systolic and diastolic blood pressure and all the stress hormones increased during stress and decreased during recovery in all subjects. Blood glucose consistently declined one hour after the meal in all subjects. However, while it continued to decline following stress in seven out of eight Caucasian subjects, it consistently increased during and following stress in 10 out of 13 Pima Indians. Fasting serum glucose in Pima Indians and Caucasians was respectively 5.07 + 0.08 mM and 5.04 + 0.09 mM. Two-hour post-prandial values were 5.63 + 0.22 mM and 5.48 + 0.19 mM respectively, whereas post-stress values were 6.15 + 0.19 mM for Pima Indians and 5.22 + 0.20 mM for Caucasians. Both serum glucose means following stress (t = 3.1, P < 0.005) and the direction of change in serum glucose in response to mental arithmetic (chi 2 = 8.2, P < 0.01) clearly differentiated Pimas from Caucasians.(ABSTRACT TRUNCATED AT 250 WORDS)}, Key = {fds276363} } @article{fds276315, Author = {Robson, WL and Leung, AK and Mathers, MS}, Title = {Kegel exercises and squatting behavior.}, Journal = {The Journal of Pediatrics}, Volume = {125}, Number = {1}, Pages = {169-170}, Year = {1994}, Month = {July}, url = {http://dx.doi.org/10.1016/s0022-3476(94)70154-7}, Doi = {10.1016/s0022-3476(94)70154-7}, Key = {fds276315} } @article{fds276391, Author = {Seldin, MF and Mott, D and Bhat, D and Petro, A and Kuhn, CM and Kingsmore, SF and Bogardus, C and Opara, E and Feinglos, MN and Surwit, RS}, Title = {Glycogen synthase: a putative locus for diet-induced hyperglycemia.}, Journal = {The Journal of Clinical Investigation}, Volume = {94}, Number = {1}, Pages = {269-276}, Year = {1994}, Month = {July}, ISSN = {0021-9738}, url = {http://www.ncbi.nlm.nih.gov/pubmed/8040269}, Keywords = {Animals • Base Sequence • Blood Glucose • Chromosome Mapping* • Diabetes Mellitus, Type 2 • Glycogen Synthase • Insulin • Male • Mice • Mice, Inbred C3H • Mice, Inbred C57BL • Molecular Sequence Data • analysis • blood • genetics*}, Abstract = {Inbred mouse strains fed a diabetogenic diet have different propensities to develop features analogous to type 2 diabetes mellitus. To define chromosomal locations that control these characteristics, recombinant inbred strains from diabetes-prone C57BL/6J (B/6J) and diabetes-resistant A/J strains were studied. Insulin levels and hyperglycemia correlated with two different regions of mouse chromosome 7 (two point LOD scores > 3.0). For insulin levels, 15 of 16 recombinant inbred strains were concordant with a region that contains the tubby mutation that results in hyperinsulinemia. For hyperglycemia, 19 of 23 strains were concordant with the D7Mit25 marker and 20 of 23 strains with the Gpi-1 locus on proximal mouse chromosome 7. Using more stringent criteria for hyperglycemia, 10 of 11 strains characterized as A/J or B/6J like were concordant with D7Mit25. This putative susceptibility locus is consistent with that of the glycogen synthase gene (Gys) recently suggested as a candidate locus by analyses of type 2 diabetes patients. Fractional glycogen synthase activity in isolated muscle was significantly lower in normal B/6J diabetic-prone mice compared with normal diabetic-resistant A/J mice, a finding similar to that reported in relatives of human patients with type 2 diabetes. These data, taken together, raise the possibility that defects in the Gys gene may in part be responsible for the propensity to develop type 2 diabetes.}, Doi = {10.1172/JCI117317}, Key = {fds276391} } @article{fds305777, Author = {SCHNEIDER, MS and KING, LR and SURWIT, RS}, Title = {KEGEL EXERCISES AND SQUATTING BEHAVIOR - REPLY}, Journal = {The Journal of Pediatrics}, Volume = {125}, Number = {1}, Pages = {170-170}, Publisher = {Mosby/Elsevier}, Year = {1994}, Month = {July}, ISSN = {0022-3476}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994NW31700037&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305777} } @article{fds276405, Author = {Livingston, EG and Feinglos, MN and Kuhn, CM and Secor, C and Surwit, RS}, Title = {Hyperinsulinemia in the pregnant C57BL/6J mouse.}, Journal = {Hormone and Metabolic Research}, Volume = {26}, Number = {6}, Pages = {307-308}, Year = {1994}, Month = {June}, ISSN = {0018-5043}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7927197}, Keywords = {Animals • Disease Models, Animal* • Female • Insulin • Mice • Mice, Inbred C57BL • Pregnancy • Pregnancy in Diabetics • blood*}, Doi = {10.1055/s-2007-1001690}, Key = {fds276405} } @article{fds276418, Author = {Schneider, MS and King, LR and Surwit, RS}, Title = {Kegel exercises and childhood incontinence: a new role for an old treatment.}, Journal = {The Journal of Pediatrics}, Volume = {124}, Number = {1}, Pages = {91-92}, Year = {1994}, Month = {January}, ISSN = {0022-3476}, url = {http://www.ncbi.nlm.nih.gov/pubmed/8283381}, Keywords = {Adolescent • Child • Child, Preschool • Exercise Therapy* • Female • Humans • Male • Muscle, Smooth • Treatment Outcome • Urinary Incontinence • physiopathology • therapy*}, Abstract = {Kegel exercises were used to treat urinary incontinence in 79 children. An average of less than 2 hours of professional time was required. Incontinence was eliminated in 60% of the patients; children who had both day and night wetting tended to show simultaneous improvements in both problems. Research is needed to test the hypothesis that Kegel exercises eliminate involuntary contractions of the detrusor muscle.}, Doi = {10.1016/s0022-3476(94)70259-4}, Key = {fds276418} } @article{fds330733, Author = {Schneider, MS and King, LR and Surwit, RS}, Title = {Reply to: Kegel exercises and squatting behavior}, Journal = {The Journal of Pediatrics}, Volume = {125}, Number = {1}, Pages = {169-170}, Publisher = {Elsevier BV}, Year = {1994}, Month = {January}, url = {http://dx.doi.org/10.1016/S0022-3476(94)70155-5}, Doi = {10.1016/S0022-3476(94)70155-5}, Key = {fds330733} } @article{fds141610, Title = {Schneider MS, King LR, Surwit RS: Kegel exercises and childhood incontinence: A new role for an old treatment. Journal of Pediatrics 124: 91-92, 1994.}, Year = {1994}, Key = {fds141610} } @article{fds276314, Author = {Surwit, RS}, Title = {Of mice and men: Behavioral medicine in the study of type II diabetes}, Journal = {Annals of Behavioral Medicine}, Volume = {15}, Number = {4}, Pages = {227-235}, Year = {1993}, Month = {December}, Abstract = {The development of a research program in behavioral medicine is reviewed from an historical perspective. Initial studies dealing with the effects of stress management on diabetes control are summarized. Questions raised by these studies led to a switch from human to animal studies. Results from these animal studies suggested that glucose responses to stress are characteristic of individuals predisposed to developing Type II diabetes. This hypothesis was then tested in humans. These studies led to the hypothesis that, while stress responsivity may be a marker for the development of diabetes, dietary effects on the sympathetic nervous system may be responsible for eventual appearance of the disease. Additionally, the development of a new animal model of Type II diabetes allowed new insights into the relationship of obesity and insulin resistance with the development of the disease itself. The evolution of this research program from one focused on behavioral variables to one with a more basic biological orientation is emphasized.}, Key = {fds276314} } @article{fds276327, Author = {Rebuffé-Scrive, M and Surwit, R and Feinglos, M and Kuhn, C and Rodin, J}, Title = {Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitus.}, Journal = {Metabolism: Clinical and Experimental}, Volume = {42}, Number = {11}, Pages = {1405-1409}, Year = {1993}, Month = {November}, ISSN = {0026-0495}, url = {http://dx.doi.org/10.1016/0026-0495(93)90190-y}, Abstract = {It has been suggested that a genetic predisposition and an increased total fat mass, particularly a specific increase in visceral fat, contribute to the metabolic aberrations associated with human non-insulin-dependent diabetes mellitus (NIDDM). In this study, we investigated the interactions between genetic and dietary components on fat distribution and metabolism in two mouse strains, one genetically predisposed to NIDDM (BL/6) and one not (A/J), fed either a chow diet or a high-fat, high-simple carbohydrate (HFHSC) diet for 5 months. As expected, both strains of mice fed a HFHSC diet were heavier, had more fat in both the subcutaneous (inguinal [ING] and visceral (mesenteric [MES]) regions, and had larger fat cells and higher lipoprotein lipase (LPL) activities. The results of interactions between strain and diet showed important differences in fat distribution and metabolism between strains. In comparison with A/J mice, BL/6 mice fed a HFHSC diet developed hyperglycemia, hyperinsulinemia, and hypercholesterolemia, were heavier, had more overall fat, and particularly increased their MES adipose tissue. This increase in visceral fat mass was due to an increase in fat cell number. In contrast, BL/6 mice fed a chow diet had less overall fat, a smaller MES fat pad with smaller adipocytes, and lower LPL activity than A/J controls. Significant differences between BL/6 and A/J mice fed either a HFHSC or a chow diet were not observed in ING adipose tissue. These data suggest that in BL/6 mice, changes in the metabolic characteristics of visceral fat seem to be a specific characteristic associated with the genetic predisposition for NIDDM.(ABSTRACT TRUNCATED AT 250 WORDS)}, Doi = {10.1016/0026-0495(93)90190-y}, Key = {fds276327} } @article{fds276420, Author = {Lane, JD and McCaskill, CC and Ross, SL and Feinglos, MN and Surwit, RS}, Title = {Relaxation training for NIDDM. Predicting who may benefit.}, Journal = {Diabetes Care}, Volume = {16}, Number = {8}, Pages = {1087-1094}, Year = {1993}, Month = {August}, ISSN = {0149-5992}, url = {http://www.ncbi.nlm.nih.gov/pubmed/8375238}, Keywords = {Analysis of Variance • Anxiety • Biofeedback (Psychology) • Blood Glucose • Blood Pressure • Diabetes Mellitus, Type 2 • Epinephrine • Female • Follow-Up Studies • Glucose Tolerance Test • Hemoglobin A, Glycosylated • Humans • Internal-External Control • Male • Relaxation Techniques* • analysis • blood • metabolism* • physiopathology • psychology* • therapy}, Abstract = {OBJECTIVE: To examine the benefits of relaxation training for patients with NIDDM and to investigate individual differences that could predict a positive response to relaxation training. RESEARCH DESIGN AND METHODS: Thirty-eight subjects with NIDDM were treated with intensive conventional diabetes therapy after an initial metabolic evaluation and psychological and pharmacological testing. Half were assigned to also receive biofeedback-assisted relaxation training. Treatment effects on GHb levels and glucose tolerance were evaluated after 8 wk. RESULTS: Subjects demonstrated significant improvements in GHb level, but not in glucose tolerance, after 8 wk of intensive conventional treatment. These improvements persisted throughout the follow-up period. However, the group provided with relaxation training did not experience greater improvements on either measure than the group given conventional diabetes treatment only. Within the group that received relaxation training, correlations occurred between the improvements in glucose tolerance after treatment and individual differences in trait anxiety and in the effect of alprazolam on glucose tolerance. Differences in the effects of EPI on glucose tolerance and personality measures of neuroticism and perceived locus of control also appeared to be related to improvements in glucose tolerance after training. CONCLUSIONS: Relaxation training did not confer added benefit over and above that provided by conventional diabetes treatment for patients with NIDDM. Additional research is needed to determine whether the administration of relaxation training to selected patients, especially those who are most responsive to stress, would provide benefits for glucose control that are not achieved by conventional treatment.}, Doi = {10.2337/diacare.16.8.1087}, Key = {fds276420} } @article{fds305784, Author = {SCHNEIDER, MS and SURWIT, RS and MCCASKILL, C}, Title = {CEPHALIC PHASE INSULIN RESPONSES ARE MEDIATED BY CHANGES IN GLUCOSE}, Journal = {Diabetes}, Volume = {42}, Pages = {A253-A253}, Publisher = {AMER DIABETES ASSOC}, Year = {1993}, Month = {May}, ISSN = {0012-1797}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993KZ62600803&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305784} } @article{fds276326, Author = {Mills, E and Kuhn, CM and Feinglos, MN and Surwit, R}, Title = {Hypertension in CB57BL/6J mouse model of non-insulin-dependent diabetes mellitus.}, Journal = {The American Journal of Physiology}, Volume = {264}, Number = {1 Pt 2}, Pages = {R73-R78}, Year = {1993}, Month = {January}, url = {http://dx.doi.org/10.1152/ajpregu.1993.264.1.R73}, Abstract = {The C57BL/6J (BL/6) mouse develops non-insulin-dependent diabetes mellitus (NIDDM) when fed a high fat-high simple carbohydrate (HFHSC) diet, whereas A/J mice do not. The purpose of the study was to determine whether hypertension occurred with NIDDM and whether it was sustained by sympathetic nervous system (SNS) hyperactivity. After 3 mo on an HFHSC diet with a low Na content (0.06%), awake, tail-cuff systolic blood pressure (BP) increased 20% above the control diet in BL/6 (138 +/- 3 vs. 115 +/- 4) but not in A/J (115 +/- 6 vs. 113 +/- 2 mmHg) mice. On a normal Na (0.4%)-HFHSC diet, BL/6 mice had a higher BP than on 0.06% Na (149 +/- 3 at 3 mo, 162 +/- 6 at 4.5 mo). After 1 mo on the 0.06% Na-HFHSC diet, direct BP of anesthetized BL/6 mice was 18% higher than control. The hypotensive response to interruption of SNS activity by ganglionic blockade (chlorisondamine) increased in the BL/6 mice (50%), whereas the heart rate response increased in both strains (20-30%). Analysis of variance (ANOVA) on glucose detected significant effects of strain and diet and a strain x diet interaction (P = 0.0007). At 1 or 3 mo, HFHSC-fed BL/6 mice were hyperglycemic (> 11 mM) compared with diet or strain controls. The ANOVA on insulin detected strain and diet effects but not a strain x diet interaction (P = 0.3). HFHSC increased insulin above the control of 140-160 pM in A/J and BL/6 strain (20-70% at 1 mo, 400% at 3 mo).(ABSTRACT TRUNCATED AT 250 WORDS)}, Doi = {10.1152/ajpregu.1993.264.1.R73}, Key = {fds276326} } @article{fds141560, Title = {Mills E, Kuhn CM, Feinglos MN, Surwit RS: Hypertension in the C57BL/6J mouse model of non-insulin dependent diabetes mellitus. American Journal of Physiology 264 (33): R73-R78, 1993.}, Year = {1993}, Key = {fds141560} } @article{fds141561, Title = {Rebuffe-Scrive M, Surwit R, Feinglos M, Kuhn C, Rodin J: Regional fat distribution and metabolism in new animal model (C57BL/6J) of NIDDM. Metabolism 42: 1405-1409, 1993.}, Year = {1993}, Key = {fds141561} } @article{fds141607, Title = {Lane JD, McCaskill CC, Ross SL, Feinglos MN, Surwit RS: Relaxation training for non-insulin dependent diabetes: Predicting who will benefit. Diabetes Care 16: 1087-1094, 1993.}, Year = {1993}, Key = {fds141607} } @article{fds141608, Title = {Surwit RS, Schneider MS: The role of stress in the etiology and treatment of diabetes mellitus. Psychosomatic Medicine 55: 380-393, 1993.}, Year = {1993}, Key = {fds141608} } @article{fds141609, Title = {Surwit RS: Of mice and men: Behavioral medicine in the study of type II diabetes. Annals of Behavioral Medicine 15: 227-235, 1993.}, Year = {1993}, Key = {fds141609} } @article{fds276429, Author = {Surwit, RS and Schneider, MS}, Title = {Role of stress in the etiology and treatment of diabetes mellitus.}, Journal = {Psychosomatic Medicine}, Volume = {55}, Number = {4}, Pages = {380-393}, Year = {1993}, ISSN = {0033-3174}, url = {http://www.ncbi.nlm.nih.gov/pubmed/8105502}, Keywords = {Animals • Anti-Anxiety Agents • Blood Glucose • Catecholamines • Cats • Combined Modality Therapy • Diabetes Mellitus, Type 1 • Diabetes Mellitus, Type 2 • Female • Humans • Hyperglycemia • Hypoglycemia • Male • Mice • Norepinephrine • Rats • Relaxation Techniques • Stress, Psychological • Sympathetic Nervous System • complications* • etiology* • metabolism • therapeutic use • therapy}, Abstract = {Stress has long been suspected as having major effects on metabolic activity. The effects of stress on glucose metabolism are mediated by a variety of "counter-regulatory" hormones that are released in response to stress and that result in elevated blood glucose levels and decreased insulin action. This energy mobilizing effect is of adaptive importance in a healthy organism. However, in diabetes, because of a relative or absolute lack of insulin, stress-induced increases in blood glucose cannot be adequately metabolized. Thus, stress is a potential contributor to chronic hyperglycemia in diabetes, although its exact role is unclear. Although there is some suggestion from retrospective human studies that stress can precipitate type I diabetes, animal studies are contradictory with different stressors either having facilitatory or inhibitory effects upon the development of the disease. Human investigations in patients with established diabetes are equally confusing with some showing that stress can stimulate hyperglycemia, hypoglycemia or have no effect at all on glycemic status. There is more consistent evidence supporting the role of stress in animal models of type II diabetes. However, human studies on the role of stress on the course of established type II diabetes are few. Intervention studies suggest that behavioral or pharmacologic intervention to manage stress may contribute significantly to diabetes treatment, but more long-term research is needed. It is concluded that further research is needed to establish the importance of behavioral factors in the etiology and management of diabetes, and several areas of methodologic improvement are suggested.}, Doi = {10.1097/00006842-199307000-00005}, Key = {fds276429} } @article{fds276432, Author = {Surwit, RS and Schneider, MS and Feinglos, MN}, Title = {Stress and diabetes mellitus.}, Journal = {Diabetes Care}, Volume = {15}, Number = {10}, Pages = {1413-1422}, Year = {1992}, Month = {October}, ISSN = {0149-5992}, url = {http://www.ncbi.nlm.nih.gov/pubmed/1425110}, Keywords = {Animals • Blood Glucose • Diabetes Mellitus • Diabetes Mellitus, Type 1 • Diabetes Mellitus, Type 2 • Humans • Mice • Mice, Obese • Stress • Stress, Psychological • metabolism • physiopathology • physiopathology* • psychology • psychology*}, Abstract = {Stress is a potential contributor to chronic hyperglycemia in diabetes. Stress has long been shown to have major effects on metabolic activity. Energy mobilization is a primary result of the fight or flight response. Stress stimulates the release of various hormones, which can result in elevated blood glucose levels. Although this is of adaptive importance in a healthy organism, in diabetes, as a result of the relative or absolute lack of insulin, stress-induced increases in glucose cannot be metabolized properly. Furthermore, regulation of these stress hormones may be abnormal in diabetes. However, evidence characterizing the effects of stress in type I diabetes is contradictory. Although some retrospective human studies have suggested that stress can precipitate type I diabetes, animal studies have shown that stressors of various kinds can precipitate--or prevent--various experimental models of the disease. Human studies have shown that stress can stimulate hyperglycemia, hypoglycemia, or have no affect at all on glycemic status in established diabetes. Much of this confusion may be attributable to the presence of autonomic neuropathy, common in type I diabetes. In contrast, more consistent evidence supports the role of stress in type II diabetes. Although human studies on the role of stress in the onset and course of type II diabetes are few, a large body of animal study supports the notion that stress reliably produces hyperglycemia in this form of the disease. Furthermore, there is mounting evidence of autonomic contributions to the pathophysiology of this condition in both animals and humans.}, Doi = {10.2337/diacare.15.10.1413}, Key = {fds276432} } @article{fds276430, Author = {Feinglos, MN and Surwit, RS and McCaskill, CC and Ross, SL}, Title = {Plasma levels of beta-endorphin and adrenocorticotropic hormone in IDDM and NIDDM.}, Journal = {Diabetes Care}, Volume = {15}, Number = {4}, Pages = {590-591}, Year = {1992}, Month = {April}, ISSN = {0149-5992}, url = {http://www.ncbi.nlm.nih.gov/pubmed/1323455}, Keywords = {Adrenocorticotropic Hormone • Adult • Analysis of Variance • Blood Glucose • Diabetes Mellitus, Type 1 • Diabetes Mellitus, Type 2 • Female • Humans • Hydrocortisone • Male • analysis • beta-Endorphin • blood • blood*}, Doi = {10.2337/diacare.15.4.590}, Key = {fds276430} } @article{fds276399, Author = {Surwit, RS and Lane, JD}, Title = {Physical activity and non-insulin dependent diabetes mellitus.}, Journal = {The New England Journal of Medicine}, Volume = {325}, Number = {26}, Pages = {1887}, Year = {1991}, Month = {December}, ISSN = {0028-4793}, url = {http://www.ncbi.nlm.nih.gov/pubmed/1797001}, Keywords = {Diabetes Mellitus, Type 2 • Exercise* • Humans • prevention & control*}, Doi = {10.1056/NEJM199112263252616}, Key = {fds276399} } @article{fds305790, Author = {MILLS, E and KUHN, CM and FEINGLOSS, MN and SURWIT, RS}, Title = {HYPERTENSION IN RELATION TO DIET INDUCED DIABETES (NIDDM) IN C57BL/6J MICE}, Journal = {Faseb Journal}, Volume = {5}, Number = {6}, Pages = {A1482-A1482}, Publisher = {FEDERATION AMER SOC EXP BIOL}, Year = {1991}, Month = {March}, ISSN = {0892-6638}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1991FE55700142&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305790} } @article{fds276365, Author = {Surwit, RS and Seldin, MF and Kuhn, CM and Cochrane, C and Feinglos, MN}, Title = {Control of expression of insulin resistance and hyperglycemia by different genetic factors in diabetic C57BL/6J mice.}, Journal = {Diabetes}, Volume = {40}, Number = {1}, Pages = {82-87}, Year = {1991}, Month = {January}, ISSN = {0012-1797}, url = {http://www.ncbi.nlm.nih.gov/pubmed/2015977}, Keywords = {Animals • Blood Glucose • Crosses, Genetic • Diabetes Mellitus, Experimental • Female • Hyperglycemia • Insulin • Insulin Resistance • Male • Mice • Mice, Inbred C57BL • Mice, Inbred Strains • Recombination, Genetic • analysis • blood • genetics* • physiopathology}, Abstract = {The inheritance of the tendency to develop diet-induced non-insulin-dependent (type II) diabetes was analyzed in crosses between diabetes-prone C57BL/6J (BL/6) mice and diabetes-resistant A/J mice. The effects of a diabetogenic diet on blood glucose and insulin levels, insulin sensitivity, and weight were evaluated in F1 and both (BL/6 X A/J) F1 X BL/6 and (BL/6 X A/J) F1 X A/J backcross mice. These results suggest that diet-induced hyperglycemia is largely determined by a recessive gene and diet-induced insulin resistance by a dominant gene. Analyses of both backcrosses indicated that insulin sensitivity and blood glucose levels were unrelated, suggesting that they are controlled by different genetic factors. This conclusion was supported by data from nine recombinant inbred BXA strains in which no correlation was observed between these variables. Furthermore, insulin sensitivity and body weight correlated differently in the two backcross groups, suggesting that insulin resistance is not simply a function of obesity. The number of genes that predominantly influence diabetic traits was estimated by comparing the variance observed in (BL/6 X A/J) F1 X BL/6 backcross mice with that observed in parental mice. The data suggest that relatively few genes predominantly affect the diabetic phenotype in this murine model.}, Doi = {10.2337/diab.40.1.82}, Key = {fds276365} } @article{fds276356, Author = {McCubbin, JA and Surwit, RS and Williams, RB and Nemeroff, CB and McNeilly, M}, Title = {Altered pituitary hormone response to naloxone in hypertension development.}, Journal = {Hypertension}, Volume = {14}, Number = {6}, Pages = {636-644}, Year = {1989}, Month = {December}, ISSN = {0194-911X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/2555303}, Keywords = {Adolescent • Adrenocorticotropic Hormone • Adult • Blood Pressure • Epinephrine • Humans • Hydrocortisone • Hypertension • Male • Naloxone • Stress, Psychological • beta-Endorphin • blood • blood* • drug effects* • pharmacology*}, Abstract = {Endogenous opioid regulation of blood pressure is altered during stress in young adults at risk for hypertension. We studied the effects of the opioid antagonist naloxone on the secretion of corticotropin and beta-endorphin during psychological stress in young adults with mildly elevated casual arterial pressures. Naloxone-induced secretion of both corticotropin and beta-endorphin was significantly diminished in persons at enhanced risk for hypertension compared with the low blood pressure control group. Results suggest that opioidergic inhibition of anterior pituitary function is altered in hypertension development.}, Doi = {10.1161/01.hyp.14.6.636}, Key = {fds276356} } @article{fds276434, Author = {Fukudo, S and Virnelli, S and Kuhn, CM and Cochrane, C and Feinglos, MN and Surwit, RS}, Title = {Muscarinic stimulation and antagonism and glucoregulation in nondiabetic and obese hyperglycemic mice.}, Journal = {Diabetes}, Volume = {38}, Number = {11}, Pages = {1433-1438}, Year = {1989}, Month = {November}, ISSN = {0012-1797}, url = {http://www.ncbi.nlm.nih.gov/pubmed/2576006}, Keywords = {Animals • Atropine • Bethanechol • Bethanechol Compounds • Blood Glucose • Dose-Response Relationship, Drug • Glucagon • Glucose • Homeostasis • Insulin • Liver • Mice • Mice, Obese • Propranolol • blood • blood* • metabolism • metabolism* • pharmacology • pharmacology* • physiology*}, Abstract = {Plasma glucose and insulin responses to a muscarinic agonist (bethanechol chloride) and a muscarinic antagonist (atropine) were evaluated in obese C57BL/6J ob/ob mice and in lean C57BL/6J + /? mice. In lean +/? mice, plasma glucose decreased in response to 1 and 2 micrograms/g bethanechol chloride, whereas insulin increased significantly. In ob/ob mice, insulin increased remarkably in response to bethanechol administration (saline, 632 +/- 80 microU/ml; 2 micrograms/g bethanechol chloride, 1794 +/- 97 microU/ml; n = 10), but surprisingly, plasma glucose also rose significantly (saline, 230 +/- 14 mg/dl; 2 micrograms/g bethanechol chloride, 363 +/- 18 mg/dl, n = 10). This exaggerated hyperglycemia in ob/ob mice was not associated with significant changes in plasma glucagon. Furthermore, administration of propranolol hydrochloride did not diminish bethanechol chloride-induced hyperglycemia in ob/ob mice. Administration of atropine (2.5, 5, and 10 mg/kg body wt) induced a significant decrease in plasma insulin without changes in plasma glucose in ob/ob mice, whereas neither plasma insulin nor plasma glucose changed in lean mice. Finally, conversion of [14C]alanine to glucose was increased in ob/ob mice after bethanechol chloride administration, indicating that muscarinic stimulation increases gluconeogenesis in an animal model of type II (non-insulin-dependent) diabetes.}, Doi = {10.2337/diab.38.11.1433}, Key = {fds276434} } @article{fds276428, Author = {Surwit, RS and McCubbin, JA and Kuhn, CM and Cochrane, C and Feinglos, MN}, Title = {Differential glycemic effects of morphine in diabetic and normal mice.}, Journal = {Metabolism: Clinical and Experimental}, Volume = {38}, Number = {3}, Pages = {282-285}, Year = {1989}, Month = {March}, ISSN = {0026-0495}, url = {http://www.ncbi.nlm.nih.gov/pubmed/2645504}, Keywords = {Animals • Blood Glucose • Diabetes Mellitus • Insulin • Mice • Mice, Inbred C57BL • Mice, Inbred Strains • Mice, Obese • Morphine • Obesity* • Stress • analysis* • blood • blood* • pharmacology*}, Abstract = {C57BL/6J ob/ob mice, C57BL/6J+/? lean mice and A/J mice were given injections of 10 mg/kg of morphine or an equal volume of saline, and then blood was sampled by retroorbital sinus puncture. In addition, animals from each strain were exposed to a brief experimental stress ten minutes after the administration of morphine or saline. While morphine produced significant increases in serum glucose in albino mice, morphine lowered blood insulin in both C57BL/6J ob/ob and C57BL/6J+/? mice. Morphine significantly lowered blood insulin in A/J mice, but effects in C57BL/6J mice were not significant. In contrast, morphine attenuated blood glucose and insulin during stress in C57BL/6J ob/ob but did not significantly affect either glucose or insulin during stress in lean C57BL/6J or A/J mice. These results are interpreted in the light of other data suggesting that endogenous opiates modulate the effects of sympathetic nervous system activity in type II diabetes.}, Doi = {10.1016/0026-0495(89)90089-9}, Key = {fds276428} } @article{fds276377, Author = {McCubbin, JA and Surwit, RS and Kuhn, CM and Cochrane, C and Feinglos, MN}, Title = {Naltrexone potentiates glycemic responses during stress and epinephrine challenge in genetically obese mice.}, Journal = {Psychosomatic Medicine}, Volume = {51}, Number = {4}, Pages = {441-448}, Year = {1989}, ISSN = {0033-3174}, url = {http://www.ncbi.nlm.nih.gov/pubmed/2549557}, Keywords = {Animals • Arousal • Blood Glucose • Diabetes Mellitus • Diabetes Mellitus, Experimental • Epinephrine • Mice • Mice, Inbred C57BL • Mice, Obese • Naltrexone • Obesity* • Receptors, Opioid • Stress, Psychological • blood* • complications* • drug effects* • genetics • metabolism* • pharmacology*}, Abstract = {The genetically obese mouse (C57BL/6J ob/ob) is a commonly used animal model of non-insulin-dependent diabetes mellitus. These mice show exaggerated glycemic responses during behavioral stress and adrenergic stimulation, but the precise glucoregulatory mechanisms are not well characterized. The ob/ob mice have multiple endocrine abnormalities, including elevated pituitary and circulating beta-endorphin levels; and a relationship between hyperglycemia and altered opioid function has been suspected. We now report that opiate antagonism with naltrexone potentiates hyperglycemic responses during stress and epinephrine challenge in obese mice. This effect of opioid blockade suggests that endogenous opioids inhibit stress- and epinephrine-induced hyperglycemia in the genetically obese mouse.}, Doi = {10.1097/00006842-198907000-00007}, Key = {fds276377} } @article{fds276431, Author = {Surwit, RS and Kuhn, CM and Cochrane, C and McCubbin, JA and Feinglos, MN}, Title = {Diet-induced type II diabetes in C57BL/6J mice.}, Journal = {Diabetes}, Volume = {37}, Number = {9}, Pages = {1163-1167}, Publisher = {American Diabetes Association}, Year = {1988}, Month = {September}, ISSN = {0012-1797}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3044882}, Keywords = {Animals • Blood Glucose • Corticosterone • Diabetes Mellitus, Experimental • Diabetes Mellitus, Type 2 • Diet* • Epinephrine • Insulin • Insulin Resistance • Male • Mice • Mice, Inbred A • Mice, Inbred C57BL • Obesity • Species Specificity • Stress • blood • etiology • metabolism • pharmacology • physiopathology • physiopathology*}, Abstract = {We investigated the effects of diet-induced obesity on glucose metabolism in two strains of mice, C57BL/6J and A/J. Twenty animals from each strain received ad libitum exposure to a high-fat high-simple-carbohydrate diet or standard Purina Rodent Chow for 6 mo. Exposure to the high-fat, high-simple-carbohydrate, low-fiber diet produced obesity in both A/J and C57BL/6J mice. Whereas obesity was associated with only moderate glucose intolerance and insulin resistance in A/J mice, obese C57BL/6J mice showed clear-cut diabetes with fasting blood glucose levels of greater than 240 mg/dl and blood insulin levels of greater than 150 microU/ml. C57BL/6J mice showed larger glycemic responses to stress and epinephrine in the lean state than AJ mice, and these responses were exaggerated by obesity. These data suggest that the C57BL/6J mouse carries a genetic predisposition to develop non-insulin-dependent (type II) diabetes. Furthermore, altered glycemic response to adrenergic stimulation may be a biologic marker for this genetic predisposition to develop type II diabetes.}, Doi = {10.2337/diab.37.9.1163}, Key = {fds276431} } @article{fds305769, Author = {MCCUBBIN, JA and SURWIT, RS and WILLIAMS, RB and STELZENMULLER, ME}, Title = {RELIABILITY AND VALIDITY OF CASUAL BLOOD PRESSURES - RELATIONSHIP BETWEEN FIELD AND LABORATORY VALUES}, Journal = {Psychophysiology}, Volume = {25}, Number = {4}, Pages = {468-468}, Publisher = {SOC PSYCHOPHYSIOL RES}, Year = {1988}, Month = {July}, ISSN = {0048-5772}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1988P919200191&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305769} } @article{fds276370, Author = {Stabler, B and Lane, JD and Ross, SL and Morris, MA and Litton, J and Surwit, RS}, Title = {Type A behavior pattern and chronic glycemic control in individuals with IDDM.}, Journal = {Diabetes Care}, Volume = {11}, Number = {4}, Pages = {361-362}, Year = {1988}, Month = {April}, ISSN = {0149-5992}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3402294}, Keywords = {Adolescent • Blood Glucose • Child • Diabetes Mellitus, Type 1 • Female • Humans • Male • Type A Personality* • blood • metabolism* • psychology*}, Doi = {10.2337/diacare.11.4.361}, Key = {fds276370} } @article{fds305789, Author = {STABLER, B and LANE, JD and ROSS, SL and MORRIS, MA and SURWIT, RS}, Title = {PSYCHOLOGICAL CORRELATES OF CHRONIC BLOOD-GLUCOSE CONTROL IN DIABETIC CHILDREN AND ADOLESCENTS}, Journal = {Psychosomatic Medicine}, Volume = {50}, Number = {2}, Pages = {194-194}, Publisher = {WILLIAMS & WILKINS}, Year = {1988}, Month = {March}, ISSN = {0033-3174}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1988M721400014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305789} } @article{fds276387, Author = {Surwit, RS and Feinglos, MN}, Title = {Stress and autonomic nervous system in type II diabetes. A hypothesis.}, Journal = {Diabetes Care}, Volume = {11}, Number = {1}, Pages = {83-85}, Year = {1988}, Month = {January}, ISSN = {0149-5992}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3276481}, Keywords = {Animals • Blood Glucose • Diabetes Mellitus, Type 2 • Humans • Hyperglycemia • Insulin • Mice • Stress • Sympathetic Nervous System • metabolism • physiopathology • physiopathology* • secretion}, Doi = {10.2337/diacare.11.1.83}, Key = {fds276387} } @article{fds276362, Author = {Morrell, EM and Surwit, RS and Kuhn, CM and Feinglos, MN and Cochrane, C}, Title = {Classically conditioned enhancement of hyperinsulinemia in the ob/ob mouse.}, Journal = {Psychosomatic Medicine}, Volume = {50}, Number = {6}, Pages = {586-590}, Year = {1988}, ISSN = {0033-3174}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3070619}, Keywords = {Animals • Arousal • Blood Glucose • Body Weight* • Conditioning, Classical • Insulin • Male • Mice • Mice, Inbred C57BL • Mice, Obese • Smell • blood* • metabolism* • physiology • physiology*}, Abstract = {The obese (C57BL/6J ob/ob) mouse is a commonly used animal model of non-insulin-dependent diabetes mellitus. Recent experiments have shown that stress hyperglycemia can be classically conditioned in the obese but not in the lean mouse. In the present study, classical conditioning of insulin secretion was attempted in C57BL/6J obese and lean animals. For 21 days, obese and lean mice were exposed to a conditioned olfactory stimulus prior to and during eating. On the 22nd day, blood was sampled for all animals following presentation of the conditioned stimulus; testing was repeated 2 weeks later following an additional 4 days of conditioning. Results indicated an effect of conditioning, with significantly greater plasma insulin for trained than for untrained obese mice. That insulin secretion can be more easily conditioned in the obese mouse suggests that a cholinergic mechanism may be involved in the hyperinsulinemia characteristic of this animal.}, Doi = {10.1097/00006842-198811000-00004}, Key = {fds276362} } @article{fds276385, Author = {McCubbin, JA and Surwit, RS and Williams, RB}, Title = {Opioid dysfunction and risk for hypertension: naloxone and blood pressure responses during different types of stress.}, Journal = {Psychosomatic Medicine}, Volume = {50}, Number = {1}, Pages = {8-14}, Year = {1988}, ISSN = {0033-3174}, url = {http://www.ncbi.nlm.nih.gov/pubmed/2830632}, Keywords = {Adolescent • Adult • Arousal • Autonomic Nervous System • Blood Pressure • Humans • Hypertension • Male • Naloxone • Neural Inhibition • Posture • Problem Solving • Receptors, Opioid • drug effects • drug effects* • pharmacology* • physiology • physiology* • physiopathology • physiopathology*}, Abstract = {Opioidergic inhibition of sympathetic nervous system responses may be deficient in persons at risk for essential hypertension (McCubbin et al: Hypertension 7:808, 1985). The opiate antagonist naloxone increases blood pressure responses during psychological stress in young adults with low causal blood pressure, but has no pressor effect in subjects with high casual blood pressure. The purpose of the present study was to determine the role of altered baroreflex function in the abnormal pressor effect of naloxone in persons at risk for hypertension development. We tested this by comparison of the effects of naloxone on responses to psychological stress with responses to orthostatic stress in persons with high and low casual blood pressure. The results suggest that abnormal opioidergic control of systolic blood pressure responses to psychological stress is not likely a result of altered baroreflex function. Persons at risk for hypertension show evidence of an opioid peptide lesion that can probably be localized either at the adrenal medullae or at levels of central autonomic control that are parallel with or rostral to baroreflex circuits.}, Doi = {10.1097/00006842-198801000-00002}, Key = {fds276385} } @article{fds276398, Author = {Lane, JD and Stabler, B and Ross, SL and Morris, MA and Litton, JC and Surwit, RS}, Title = {Psychological predictors of glucose control in patients with IDDM.}, Journal = {Diabetes Care}, Volume = {11}, Number = {10}, Pages = {798-800}, Year = {1988}, ISSN = {0149-5992}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3246201}, Keywords = {Adolescent • Blood Glucose • Blood Glucose Self-Monitoring • Diabetes Mellitus, Type 1 • Female • Hemoglobin A, Glycosylated • Humans • Male • Patient Compliance • Personality Tests • Personality* • Prognosis • analysis • analysis* • blood • psychology*}, Doi = {10.2337/diacare.11.10.798}, Key = {fds276398} } @article{fds305802, Author = {Surwit, RS and Feinglos, MN}, Title = {Relaxation Therapy: A Reply}, Journal = {Diabetes Care}, Volume = {10}, Number = {6}, Pages = {794-795}, Publisher = {American Diabetes Association}, Year = {1987}, Month = {November}, ISSN = {0149-5992}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1987L246800034&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Doi = {10.2337/diacare.10.6.794b}, Key = {fds305802} } @article{fds305776, Author = {MCCUBBIN, JA and SURWIT, RS and WILLIAMS, RB and NEMEROFF, CB}, Title = {ABNORMAL OPIOIDERGIC INHIBITION OF THE HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL AXIS IN HUMANS AT RISK FOR HYPERTENSION}, Journal = {Psychophysiology}, Volume = {24}, Number = {5}, Pages = {600-600}, Publisher = {SOC PSYCHOPHYSIOL RES}, Year = {1987}, Month = {September}, ISSN = {0048-5772}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1987J727200127&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305776} } @article{fds276379, Author = {Hand, MS and Surwit, RS and Rodin, J and Van Order and P and Feinglos, MN}, Title = {Failure of genetically selected miniature swine to model NIDDM.}, Journal = {Diabetes}, Volume = {36}, Number = {3}, Pages = {284-287}, Year = {1987}, Month = {March}, ISSN = {0012-1797}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3542650}, Keywords = {Animals • Blood Glucose • Diabetes Mellitus, Type 2* • Diet • Disease Models, Animal* • Female • Glucose Tolerance Test • Insulin • Male • Swine • Swine, Miniature • analysis • blood • genetics* • metabolism}, Abstract = {Ten young adult miniature swine from a line reported to be genetically selected for glucose intolerance and eight normal controls were obtained from Colorado State University. They were consecutively exposed to 4 mo of a high-fiber, low-fat standard swine diet; 4 mo of a high-sucrose, high-fat, low-fiber diabetogenic diet; and 4 mo of excess diabetogenic diet for obesification. Results of oral glucose tolerance and intravenous insulin tolerance tests conducted at the end of each regimen were compared. Hyperglycemia was not observed in any animals after any manipulation. Insulin sensitivity was also not influenced by diet. We conclude that F7 low-K miniature swine from this colony fail to model human non-insulin-dependent diabetes.}, Doi = {10.2337/diab.36.3.284}, Key = {fds276379} } @article{fds276390, Author = {Kuhn, CM and Cochrane, C and Feinglos, MN and Surwit, RS}, Title = {Exaggerated peripheral responses to catecholamines contributes to stress-induced hyperglycemia in the ob/ob mouse.}, Journal = {Pharmacology, Biochemistry, and Behavior}, Volume = {26}, Number = {3}, Pages = {491-495}, Year = {1987}, Month = {March}, ISSN = {0091-3057}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3554269}, Keywords = {Adrenergic Fibers • Animals • Blood Glucose • Diabetes Mellitus • Dose-Response Relationship, Drug • Epinephrine • Fasting • Hyperglycemia • Insulin • Mice • Mice, Inbred C57BL • Mice, Obese • Obesity* • Phentolamine • Stress • blood • blood* • drug effects • metabolism • pharmacology* • physiology • physiopathology*}, Abstract = {The present study investigated the contribution of altered sympathetic reactivity to the stress-induced hyperglycemia observed in the c57BL/6J (ob/ob) mouse, an animal model of type II diabetes. Blood glucose and insulin responses to sympathetic agonist and antagonist administration were evaluated in ob/ob mice and their nondiabetic, lean (ob/?) littermates. In addition, the ability of nutritional status to modify these responses was determined. These studies demonstrated that epinephrine administration to ob/ob mice caused an exaggerated increase in blood glucose and decrease in plasma insulin in ob/ob mice relative to lean littermates. The dose response curve for epinephrine-induced increases in blood glucose were shifted to the left, and the duration of the blood glucose and plasma insulin responses was longer. Differences between ob/ob mice and their nondiabetic littermates were greater when animals were tested in the fasted state. In addition, administration of the alpha adrenergic antagonist phentolamine caused a larger increase in plasma insulin in ob/ob mice than was observed in lean littermates. These results suggest that altered peripheral responses to sympathetic stimuli contribute to stress-induced hyperglycemia in ob/ob mice, and raise the possibility that altered sympathetic function is an etiologic factor in development of diabetes in these animals.}, Doi = {10.1016/0091-3057(87)90154-7}, Key = {fds276390} } @article{fds276313, Author = {McCubbin, JA and Surwit, RS and Mansbach, CM}, Title = {Sensory discrimination training in the treatment of a case of chronic constipation}, Journal = {Behavior Therapy}, Volume = {18}, Number = {3}, Pages = {273-278}, Publisher = {Elsevier BV}, Year = {1987}, Month = {January}, ISSN = {0005-7894}, url = {http://dx.doi.org/10.1016/S0005-7894(87)80021-7}, Abstract = {A 31-year-old woman with a history of life-long constipation and laxative dependence was treated with discrimination training for rectal sensation. She had complained of absence of the urge to defecate, bloating with abdominal discomfort, and need for laxatives to relieve symptoms. Manometric examination with an anorectal balloon assembly revealed a normal threshold for sphincteric reflexes, but an abnormally elevated threshold for detection of rectal distention. Behavioral treatment consisted of a manometrically based sensory discrimination procedure designed to reduce the sensory threshold for rectal distention. Multiple training sessions with this procedure allowed recognition of progressively smaller rectal distention volumes. Accompanying these changes in rectal sensory threshold were concomitant increases in the frequency of bowel movements, decreases in the weekly use of laxatives, and decreases in subjective discomfort. Therapeutic effects were maintained at follow-up examination one year later. The results of this case study suggest that behavioral training to increase rectal sensation may be useful in treating constipation in patients who have abnormal rectal sensory thresholds. © 1987 Association for Advancement of Behavior Therapy. All rights reserved.}, Doi = {10.1016/S0005-7894(87)80021-7}, Key = {fds276313} } @article{fds305805, Author = {Surwit, RS and Feinglos, MN}, Title = {Cognitive Functioning and Diabetes: A Reply}, Journal = {Diabetes Care}, Volume = {10}, Number = {1}, Pages = {136-137}, Publisher = {American Diabetes Association}, Year = {1987}, Month = {January}, ISSN = {0149-5992}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1987F969100027&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Doi = {10.2337/diacare.10.1.136}, Key = {fds305805} } @article{fds276386, Author = {Stabler, B and Surwit, RS and Lane, JD and Morris, MA and Litton, J and Feinglos, MN}, Title = {Type A behavior pattern and blood glucose control in diabetic children.}, Journal = {Psychosomatic Medicine}, Volume = {49}, Number = {3}, Pages = {313-316}, Year = {1987}, ISSN = {0033-3174}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3602301}, Keywords = {Adolescent • Arousal • Blood Glucose • Child • Diabetes Mellitus, Type 1 • Female • Humans • Male • Type A Personality* • blood • metabolism* • physiology • psychology*}, Abstract = {We studied the relationship between presence of Type A behavior pattern and glycemic response to stress in children with insulin dependent diabetes mellitus (IDDM). Twelve male (six Type A and six Type B) and nine female (four Type A and five Type B) insulin-dependent diabetic patients between the ages of 8 and 16 years received a standard meal and blood glucose values were assessed two hours later. All subjects then played a competitive videogame for 10 minutes following which blood glucose was assessed again. Preprandial and postprandial blood glucose values did not differ between the groups. However, only Type A subjects showed a hyperglycemic response to the videogame stress. Type A subjects also demonstrated significantly higher glycohemoglobin values. In order to assure that this effect was due to a differential response to stress and not simply a difference in metabolic response to a meal, a second study was conducted in which blood glucose values were assessed at one, two and three hours following a standard meal. No significant differences in postprandial blood glucose values were observed between Type A and Type B subjects. These data support previous research which has suggested that some but not all patients with IDDM show a hyperglycemic response to stress.}, Doi = {10.1097/00006842-198705000-00010}, Key = {fds276386} } @article{fds276427, Author = {Feinglos, MN and Hastedt, P and Surwit, RS}, Title = {Effects of relaxation therapy on patients with type I diabetes mellitus.}, Journal = {Diabetes Care}, Volume = {10}, Number = {1}, Pages = {72-75}, Year = {1987}, ISSN = {0149-5992}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3552516}, Keywords = {Adult • Biofeedback (Psychology)* • Blood Glucose • Diabetes Mellitus, Type 1 • Diabetes Mellitus, Type 2 • Electromyography • Epinephrine • Female • Humans • Hydrocortisone • Insulin • Male • Muscle Contraction* • Muscle Relaxation* • Norepinephrine • administration & dosage • blood • drug therapy • metabolism • therapeutic use • therapy • therapy*}, Abstract = {We investigated the effect of treatment with biofeedback-associated progressive muscle relaxation on 10 patients with poorly controlled type I diabetes mellitus compared with 10 equivalent untreated patients. In contrast to previous studies of patients with type II diabetes, no improvement occurred in glucose tolerance after 1 wk of intensive in-hospital relaxation training or in glycohemoglobin and total daily insulin dose after 6 wk of practicing relaxation techniques at home. This and other studies suggest that this type and amount relaxation therapy may not be as useful for enhancing blood glucose control in patients with type I diabetes as in those with type II diabetes. However, subpopulations of type I diabetic patients who have demonstrated stress-induced hyperglycemia should be further investigated.}, Doi = {10.2337/diacare.10.1.72}, Key = {fds276427} } @article{fds305772, Author = {MCCUBBIN, JA and SURWIT, RS and WILLIAMS, RB and NEMEROFF, CB}, Title = {NALOXONE AND BLOOD-PRESSURE RESPONSES TO DIFFERENT TYPES OF STRESS}, Journal = {Psychophysiology}, Volume = {23}, Number = {4}, Pages = {451-451}, Publisher = {SOC PSYCHOPHYSIOL RES}, Year = {1986}, Month = {July}, ISSN = {0048-5772}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1986D953600140&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305772} } @article{fds305809, Author = {STABLER, B and SURWIT, RS and LANE, JD and MORRIS, MA and FEINGLOS, MN}, Title = {GLYCEMIC RESPONSE TO STRESS IN CHILDREN WITH INSULIN-DEPENDENT DIABETES}, Journal = {Psychophysiology}, Volume = {23}, Number = {4}, Pages = {463-464}, Publisher = {SOC PSYCHOPHYSIOL RES}, Year = {1986}, Month = {July}, ISSN = {0048-5772}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1986D953600186&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305809} } @article{fds305798, Author = {SURWIT, RS and FEINGLOS, MN and COCHRANE, C and KUHN, CM}, Title = {ALTERED ALPHA-ADRENERGIC RESPONSIVITY IN C576J MICE}, Journal = {Diabetes}, Volume = {35}, Pages = {A19-A19}, Publisher = {AMER DIABETES ASSOC}, Year = {1986}, Month = {May}, ISSN = {0012-1797}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1986C237100074&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305798} } @article{fds305810, Author = {STABLER, BS and MORRIS, MA and LITTON, J and FEINGLOS, MN and SURWIT, RS}, Title = {TYPE-A BEHAVIOR PATTERN AND GLYCEMIC CONTROL IN IDDM}, Journal = {Diabetes}, Volume = {35}, Pages = {A110-A110}, Publisher = {AMER DIABETES ASSOC}, Year = {1986}, Month = {May}, ISSN = {0012-1797}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1986C237100435&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305810} } @article{fds276352, Author = {Surwit, RS and McCubbin, JA and Kuhn, CM and McGee, D and Gerstenfeld, D and Feinglos, MN}, Title = {Alprazolam reduces stress hyperglycemia in ob/ob mice.}, Journal = {Psychosomatic Medicine}, Volume = {48}, Number = {3-4}, Pages = {278-282}, Year = {1986}, ISSN = {0033-3174}, url = {http://www.ncbi.nlm.nih.gov/pubmed/2871583}, Keywords = {Alprazolam • Animals • Anti-Anxiety Agents • Benzodiazepines • Blood Glucose • Diabetes Mellitus, Experimental • Hyperglycemia • Insulin • Mice • Mice, Inbred C57BL • Mice, Obese • Stress, Psychological • blood • complications* • drug therapy* • metabolism • therapeutic use*}, Abstract = {We have shown that the C57BL/6J ob/ob (obese) mouse, a commonly used model of type II diabetes mellitus, is not in fact consistently hyperglycemic except when exposed to environmental stress. In an attempt to modify stress hyperglycemia in this animal, we administered either a 5 mg/kg dose of the benzodiazepine alprazolam or vehicle (propylene glycol) intraperitoneally to both obese mice and their lean littermates prior to a rest and a stress period. Alprazolam modified the hyperglycemic effect of stress only in the obese mice. Alprazolam significantly reduced plasma corticosterone in obese animals at rest and following stress. In addition, alprazolam significantly increased plasma insulin in all animals at rest and following stress. These data suggest a possible role for benzodiazepines in the modification of stress hyperglycemia in type II diabetes mellitus.}, Doi = {10.1097/00006842-198603000-00013}, Key = {fds276352} } @article{fds276360, Author = {Stabler, B and Morris, MA and Litton, J and Feinglos, MN and Surwit, RS}, Title = {Differential glycemic response to stress in type A and type B individuals with IDDM.}, Journal = {Diabetes Care}, Volume = {9}, Number = {5}, Pages = {550-552}, Year = {1986}, ISSN = {0149-5992}, url = {http://www.ncbi.nlm.nih.gov/pubmed/3769723}, Keywords = {Adolescent • Blood Glucose • Child • Diabetes Mellitus, Type 1 • Eating • Female • Humans • Male • Personality* • Stress, Psychological • Type A Personality* • blood • metabolism* • physiopathology* • psychology*}, Doi = {10.2337/diacare.9.5.550b}, Key = {fds276360} } @article{fds276397, Author = {Surwit, RS and McCubbin, JA and Livingston, EG and Feinglos, MN}, Title = {Classically conditioned hyperglycemia in the obese mouse.}, Journal = {Psychosomatic Medicine}, Volume = {47}, Number = {6}, Pages = {565-568}, Year = {1985}, ISSN = {0033-3174}, url = {http://www.ncbi.nlm.nih.gov/pubmed/4070525}, Keywords = {Animals • Blood Glucose • Conditioning, Classical* • Diabetes Mellitus, Type 2 • Hyperglycemia • Mice • Mice, Obese • Stress, Psychological • analysis • blood • blood* • etiology*}, Abstract = {The obese (C57BL/6J ob/ob) mouse is a commonly used animal model of non-insulin-dependent diabetes mellitus. It has recently been demonstrated that this mouse is not consistently hyperglycemic, however, unless it is subjected to environmental stress. In the present study, hyperglycemia in obese mice was induced by classical conditioning. Obese diabetic mice and lean control animals were exposed to shaking stress. All animals developed hyperglycemia in response to shaking. To demonstrate classical conditioning, some obese and lean animals were exposed to a metronome prior to and during the shaking. Other animals were exposed to the metronome and shaking in a noncontingent fashion and one group of animals was exposed to the metronome without any exposure to shaking. All animals received seven exposures to one of the three above conditions over a 3-day period. On the 4th day all animals were exposed to the metronome alone, following which blood samples were drawn. Classical conditioning of stress hyperglycemia was demonstrated in obese, but not in lean, mice.}, Doi = {10.1097/00006842-198511000-00006}, Key = {fds276397} } @article{fds276413, Author = {McCubbin, JA and Surwit, RS and Williams, RB}, Title = {Endogenous opiate peptides, stress reactivity, and risk for hypertension.}, Journal = {Hypertension}, Volume = {7}, Number = {5}, Pages = {808-811}, Year = {1985}, ISSN = {0194-911X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/4030048}, Keywords = {Adolescent • Adult • Blood Pressure • Endorphins • Humans • Hypertension • Male • Naloxone • Risk • Stress, Psychological • complications* • etiology* • pharmacology • physiology*}, Abstract = {Endogenous opiate peptides can regulate neuroendocrine and circulatory responses to behavioral stress and may be important in the pathogenic effects of sympathoadrenal reactivity. We tested this hypothesis by examining the effect of the opiate antagonist naloxone on blood pressure responses to behavioral stress in young adults with high, medium, or low casual blood pressures. Naloxone increased mean arterial pressure responses to stress in subjects with low casual pressure, but had no significant effect on responses in subjects with high casual pressure. These results suggest opioidergic inhibition of sympathetic nervous system responses may be deficient in persons at risk for essential hypertension.}, Doi = {10.1161/01.hyp.7.5.808}, Key = {fds276413} } @article{fds276358, Author = {Surwit, RS and Rotberg, M}, Title = {Biofeedback therapy of essential blepharospasm.}, Journal = {American Journal of Ophthalmology}, Volume = {98}, Number = {1}, Pages = {28-31}, Year = {1984}, Month = {July}, ISSN = {0002-9394}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6742078}, Keywords = {Aged • Biofeedback (Psychology)* • Blepharospasm • Blinking • Electromyography • Eyelid Diseases • Female • Humans • Male • Middle Aged • physiopathology • therapy*}, Abstract = {Eight patients with essential blepharospasm were given five consecutive sessions of electromyogram biofeedback from cutaneous electrodes placed over the frontalis muscle. Four of the eight patients demonstrated a 60% or greater reduction in blepharospasm frequency. Posttreatment electromyogram significantly predicted improvement of blepharospasm. These data suggest that electromyogram biofeedback may provide a therapeutic alternative to the treatment of this disabling condition.}, Doi = {10.1016/0002-9394(84)90184-3}, Key = {fds276358} } @article{fds276426, Author = {Surwit, RS and Feinglos, MN and Livingston, EG and Kuhn, CM and McCubbin, JA}, Title = {Behavioral manipulation of the diabetic phenotype in ob/ob mice.}, Journal = {Diabetes}, Volume = {33}, Number = {7}, Pages = {616-618}, Year = {1984}, Month = {July}, ISSN = {0012-1797}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6376217}, Keywords = {Animals • Blood Glucose • Corticosterone • Diabetes Mellitus • Epinephrine • Handling (Psychology) • Insulin • Mice • Mice, Inbred C57BL • Mice, Obese • Phenotype • Restraint, Physical • Rodent Diseases • Stress • blood • blood* • metabolism* • pharmacology* • veterinary*}, Abstract = {The genetically obese mouse (C57BL/6J ob/ob) is a commonly used model of non-insulin-dependent diabetes mellitus. However, our studies demonstrate that, while the animal is significantly hyperinsulinemic, it in fact does not show consistent hyperglycemia in the resting state. During stress, both obese animals and their lean littermates become hyperglycemic, but the magnitude of the hyperglycemia is exaggerated in the obese mice. Obese animals also show an exaggerated plasma glucose increase in response to epinephrine injection. This increase in plasma glucose is accompanied by a decrease in plasma insulin in response to both stress and epinephrine. Our findings suggest that environmental stimuli influence the expression of diabetes in the C57BL/6J obese mouse and therefore must be considered in studies of this animal model of diabetes.}, Doi = {10.2337/diab.33.7.616}, Key = {fds276426} } @article{fds276364, Author = {Surwit, RS and Gilgor, RS and Allen, LM and Duvic, M}, Title = {A double-blind study of prazosin in the treatment of Raynaud's phenomenon in scleroderma.}, Journal = {Archives of Dermatology}, Volume = {120}, Number = {3}, Pages = {329-331}, Year = {1984}, Month = {March}, ISSN = {0003-987X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6367665}, Keywords = {Adult • Clinical Trials • Double-Blind Method • Female • Humans • Male • Middle Aged • Prazosin • Quinazolines • Raynaud Disease • Scleroderma, Systemic • complications • drug therapy* • therapeutic use*}, Abstract = {Nineteen patients with Raynaud's phenomenon in conjunction with progressive systemic sclerosis were given either prazosin hydrochloride (1 mg orally three times a day) or a placebo for eight weeks, after which the treatment procedure was reversed for four weeks. Prazosin was shown to be effective in reducing both the frequency and the severity of vasospasm reported by the patients.}, Doi = {10.1001/archderm.1984.01650390051010}, Key = {fds276364} } @article{fds305773, Author = {MCCUBBIN, JA and SURWIT, RS and WILLIAMS, RB}, Title = {STRESS REACTIVITY, ENDOGENOUS OPIATE PEPTIDES AND RISK FOR HYPERTENSION}, Journal = {Psychophysiology}, Volume = {21}, Number = {5}, Pages = {587-587}, Publisher = {SOC PSYCHOPHYSIOL RES}, Year = {1984}, Month = {January}, ISSN = {0048-5772}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1984TF32000101&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305773} } @article{fds305794, Author = {SURWIT, RS and MCCUBBIN, JA and GERSTENFELD, DA and MCGEE, DJ and FEINGLOS, MN}, Title = {ALPRAZOLAM ATTENUATES STRESS-INDUCED HYPERGLYCEMIA}, Journal = {Psychosomatic Medicine}, Volume = {46}, Number = {3}, Pages = {287-287}, Publisher = {WILLIAMS & WILKINS}, Year = {1984}, Month = {January}, ISSN = {0033-3174}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1984SU35200016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305794} } @article{fds276359, Author = {Surwit, RS and Feinglos, MN}, Title = {Relaxation-induced improvement in glucose tolerance is associated with decreased plasma cortisol.}, Journal = {Diabetes Care}, Volume = {7}, Number = {2}, Pages = {203-204}, Year = {1984}, ISSN = {0149-5992}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6734387}, Keywords = {Glucose Tolerance Test* • Humans • Hydrocortisone • Relaxation* • blood*}, Doi = {10.2337/diacare.7.2.203}, Key = {fds276359} } @article{fds276396, Author = {Surwit, RS and Gilgor, RS and Duvic, M and Allen, LM and Neal, JA}, Title = {Intra-arterial reserpine for Raynaud's syndrome. Systemic reactions without therapeutic benefit.}, Journal = {Archives of Dermatology}, Volume = {119}, Number = {9}, Pages = {733-735}, Publisher = {American Medical Association (AMA)}, Year = {1983}, Month = {September}, ISSN = {0003-987X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6614959}, Keywords = {Adult • Brachial Artery • Cardiac Output • Double-Blind Method • Female • Heart Rate • Humans • Injections, Intra-Arterial • Male • Middle Aged • Raynaud Disease • Reserpine • Skin Temperature • Stroke Volume • administration & dosage* • adverse effects • drug effects • drug effects* • drug therapy* • therapeutic use}, Abstract = {Twenty-four patients classified as having Raynaud's disease or Raynaud's phenomenon were given bilateral brachial artery injections of reserpine or saline in a double-blind fashion. In the six weeks following injection, there was no indication that reserpine produced clinical improvement or changed vasomotor reactivity in the treated patients. However, intra-arterial reserpine did produce systemic cardiovascular effects lasting up to six weeks. It is concluded that intra-arterial reserpine as used in this study is an ineffective treatment for Raynaud's disease or Raynaud's phenomenon and may have significant adverse effects.}, Doi = {10.1001/archderm.1983.01650330025008}, Key = {fds276396} } @article{fds276409, Author = {Surwit, RS and Keefe, FJ}, Title = {The blind leading the blind: problems with the "double-blind" design in clinical biofeedback research.}, Journal = {Biofeedback and Self Regulation}, Volume = {8}, Number = {1}, Pages = {1-8}, Year = {1983}, Month = {March}, ISSN = {0363-3586}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6882807}, Keywords = {Biofeedback (Psychology)* • Double-Blind Method • Humans • Raynaud Disease • Research • Skin Temperature • therapy*}, Doi = {10.1007/BF01000531}, Key = {fds276409} } @article{fds276389, Author = {Surwit, RS and Allen, LM and Gilgor, RS and Schanberg, S and Kuhn, C and Duvic, M}, Title = {Neuroendocrine response to cold in Raynaud's syndrome.}, Journal = {Life Sciences}, Volume = {32}, Number = {9}, Pages = {995-1000}, Year = {1983}, Month = {February}, ISSN = {0024-3205}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6600810}, Keywords = {Antibodies, Antinuclear • Cold* • Female • Humans • Hydrocortisone • Norepinephrine • Raynaud Disease • Time Factors • analysis • blood • blood* • physiopathology*}, Abstract = {Eleven patients with Raynaud's syndrome accompanied by monospecific IgG ANA, nine patients with Raynaud's syndrome in the absence of ANA, and nine normal volunteers were exposed to an ambient cold challenge during which time venous blood was continuously sampled. ANA negative patients were shown to have significantly higher levels of cortisol during a cold challenge than either ANA positive patients or normal controls, and exhibited significantly lower levels of plasma norepinephrine compared with normal controls. ANA positive patients did not differ significantly from normals in their neuroendocrine response to cold. It is suggested that the high plasma cortisol found in Raynaud's syndrome in the absence of ANA may be responsible for the vasospasticity in this group of patients.}, Doi = {10.1016/0024-3205(83)90930-x}, Key = {fds276389} } @article{fds305797, Author = {SURWIT, RS and FEINGLOS, MN}, Title = {THE EFFECTS OF RELAXATION ON GLUCOSE-TOLERANCE}, Journal = {Psychosomatic Medicine}, Volume = {45}, Number = {1}, Pages = {83-83}, Publisher = {WILLIAMS & WILKINS}, Year = {1983}, Month = {January}, ISSN = {0033-3174}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1983QG57900032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305797} } @article{fds305800, Author = {SURWIT, RS and FEINGLOS, MN and HASTEDT, P}, Title = {THE EFFECTS OF RELAXATION ON GLUCOSE-TOLERANCE IN INSULIN DEPENDENT DIABETES}, Journal = {Diabetes}, Volume = {32}, Pages = {A171-A171}, Publisher = {AMER DIABETES ASSOC}, Year = {1983}, Month = {January}, ISSN = {0012-1797}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1983QV86300645&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305800} } @article{fds276401, Author = {Surwit, RS and Feinglos, MN}, Title = {The effects of relaxations on glucose tolerance in non-insulin-dependent diabetes.}, Journal = {Diabetes Care}, Volume = {6}, Number = {2}, Pages = {176-179}, Year = {1983}, ISSN = {0149-5992}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6343022}, Keywords = {Adult • Aged • Blood Glucose • Body Weight • Diabetes Mellitus • Female • Glucose Tolerance Test • Humans • Insulin • Male • Middle Aged • Relaxation Techniques* • administration & dosage • analysis* • secretion • therapy*}, Abstract = {Twelve patients with non-insulin-dependent diabetes mellitus were hospitalized on a clinical research ward under identical conditions. A 3-h glucose tolerance test and an intravenous insulin tolerance test were performed on each patient. Half of the patients were then given 5 days of progressive relaxation training after which all patients were retested while treated patients practiced relaxation. Relaxation was found to significantly improve glucose tolerance without affecting insulin sensitivity or glucose-stimulated insulin secretory activity.}, Doi = {10.2337/diacare.6.2.176}, Key = {fds276401} } @article{fds276414, Author = {Surwit, RS and Feinglos, MN and Scovern, AW}, Title = {Diabetes and behavior: A paradigm for health psychology.}, Journal = {American Psychologist}, Volume = {38}, Number = {3}, Pages = {255-262}, Publisher = {American Psychological Association (APA)}, Year = {1983}, ISSN = {0003-066X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6870041}, Keywords = {Adaptation, Psychological • Blood Glucose • Diabetes Mellitus • Humans • Psychophysiologic Disorders • Sick Role* • metabolism • psychology*}, Doi = {10.1037/0003-066x.38.3.255}, Key = {fds276414} } @article{fds305807, Author = {Surwit, RS and Feinglos, MN and Livingston, EG and Kuhn, CM and McCubbin, JA}, Title = {Stress and the expression of the diabetic phenotype in OB/OB mice}, Journal = {Psychophysiology}, Volume = {20}, Number = {4}, Pages = {474-474}, Publisher = {SOC PSYCHOPHYSIOL RES}, Year = {1983}, ISSN = {0048-5772}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1983RF28200200&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305807} } @article{fds276371, Author = {Surwit, RS and Allen, LM and Gilgor, RS and Duvic, M}, Title = {The combined effect of prazosin and autogenic training on cold reactivity in Raynaud's phenomenon.}, Journal = {Biofeedback and Self Regulation}, Volume = {7}, Number = {4}, Pages = {537-544}, Year = {1982}, Month = {December}, ISSN = {0363-3586}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7165784}, Keywords = {Adult • Autogenic Training* • Blood Pressure • Cold* • Female • Fingers • Humans • Male • Middle Aged • Prazosin • Quinazolines • Raynaud Disease • Scleroderma, Systemic • Skin • Skin Temperature • blood supply • complications • drug effects • therapeutic use* • therapy*}, Doi = {10.1007/BF00998892}, Key = {fds276371} } @article{fds276433, Author = {Surwit, RS}, Title = {Behavioral treatment of Raynaud's syndrome in peripheral vascular disease.}, Journal = {Journal of Consulting and Clinical Psychology}, Volume = {50}, Number = {6}, Pages = {922-932}, Year = {1982}, Month = {December}, ISSN = {0022-006X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7174981}, Keywords = {Behavior Therapy • Biofeedback (Psychology) • Humans • Muscle Relaxation • Prognosis • Raynaud Disease • methods* • psychology • therapy*}, Doi = {10.1037//0022-006x.50.6.922}, Key = {fds276433} } @article{fds276349, Author = {Steptoe, A and Surwit, R}, Title = {Behavioral medicine}, Journal = {Journal of Psychosomatic Research}, Volume = {26}, Number = {5}, Pages = {467-468}, Publisher = {Elsevier BV}, Year = {1982}, Month = {January}, ISSN = {0022-3999}, url = {http://dx.doi.org/10.1016/0022-3999(82)90085-X}, Doi = {10.1016/0022-3999(82)90085-X}, Key = {fds276349} } @article{fds276422, Author = {Surwit, RS and Scovern, AW and Feinglos, MN}, Title = {The role of behavior in diabetes care.}, Journal = {Diabetes Care}, Volume = {5}, Number = {3}, Pages = {337-342}, Year = {1982}, ISSN = {0149-5992}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6756844}, Keywords = {Autonomic Nervous System • Behavior* • Diabetes Mellitus • Humans • Life Style • Patient Compliance • Psychosomatic Medicine • Sympathetic Nervous System • physiopathology • psychology* • therapy}, Abstract = {The treatment of people with diabetes mellitus almost always involves an effort on the part of the health-care team to impose new patterns of behavior on their patients. Too often this behavior modification is undertaken without any specific attention to factors in the treatment regimen that may enhance or detract from patient compliance. If, however, the treatment of disease is viewed in terms of changes in both physiology and behavior, the importance of intervention aimed at either direct behavioral manipulation of physiology, or alterations of secondary behavior related to the disease and its therapy, becomes apparent. We have reviewed in this paper the current "state of the art" of both direct behavioral treatment of diabetes and techniques to enhance compliance with treatment program.}, Doi = {10.2337/diacare.5.3.337}, Key = {fds276422} } @article{fds276366, Author = {Keefe, FJ and Block, AR and Williams, RB and Surwit, RS}, Title = {Behavioral treatment of chronic low back pain: clinical outcome and individual differences in pain relief.}, Journal = {Pain}, Volume = {11}, Number = {2}, Pages = {221-231}, Year = {1981}, Month = {October}, ISSN = {0304-3959}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6459557}, Keywords = {Adult • Back Pain • Behavior Therapy • Biofeedback (Psychology) • Chronic Disease • Electromyography • Female • Humans • Individuality • MMPI • Male • Outcome and Process Assessment (Health Care) • Relaxation Techniques • methods* • psychology • therapy • therapy*}, Abstract = {The response of 111 chronic low back pain patients to a comprehensive behavioral treatment program emphasizing relaxation procedures is examined. Over the course of treatment, significant reductions were obtained on measures of subjective tension, EMG activity, and pain. Many patients also decreased their intake of analgesic/narcotic agents and reported an increase in activity level. In order to examine individual differences in pain relief, the 28 patients who had the greatest decreases in pain were compared to those who had the least decreases in pain. Patients who had the best outcome in terms of pain relief were significantly more likely to show improvements in other outcome measures. In addition, these patients rated their pain initially as more severe, had continuous pain for fewer years, and were less likely to be on disability or to have had multiple surgical procedures. These results are discussed in the light of recent data from other behavioral treatment studies with chronic low back pain patients and implications for behavioral assessment and treatment are discussed.}, Doi = {10.1016/0304-3959(81)90007-5}, Key = {fds276366} } @article{fds276408, Author = {Rotberg, MH and Surwit, RS}, Title = {Biofeedback techniques in the treatment of visual and ophthalmologic disorders: a review of the literature.}, Journal = {Biofeedback and Self Regulation}, Volume = {6}, Number = {3}, Pages = {375-388}, Year = {1981}, Month = {September}, ISSN = {0363-3586}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7034790}, Keywords = {Biofeedback (Psychology)* • Blepharospasm • Eye Diseases • Eye Movements • Female • Humans • Intraocular Pressure • Middle Aged • Myopia • Nystagmus, Pathologic • Oculomotor Muscles • Strabismus • Vision Disorders • Visual Acuity • physiology • therapy • therapy*}, Abstract = {The literature on the use of biofeedback techniques in the treatment of visual and ophthalmologic disorders is reviewed. Although this consists mainly of case studies, there is mounting evidence that biofeedback may be applicable to the treatment of strabismus, nystagmus, blepharospasm, elevated intraocular pressure, and myopia. because of the success in applying biofeedback techniques in the treatment of other neuromuscular disorders, it is concluded that the use of these techniques in the treatment of blepharospasm and strabismus shows the most promise.}, Doi = {10.1007/BF01000662}, Key = {fds276408} } @article{fds276375, Author = {Keefe, FJ and Surwit, RS and Pilon, RN}, Title = {Collagen vascular disease: can behavior therapy help?}, Journal = {Journal of Behavior Therapy and Experimental Psychiatry}, Volume = {12}, Number = {2}, Pages = {171-175}, Year = {1981}, Month = {June}, ISSN = {0005-7916}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7276192}, Keywords = {Autogenic Training • Behavior Therapy • Biofeedback (Psychology) • Body Temperature Regulation • Female • Humans • Middle Aged • Mixed Connective Tissue Disease • Raynaud Disease • methods* • psychology • therapy*}, Abstract = {This study examined the efficacy of a simple autogenic and biofeedback treatment package in the management of Raynaud's Phenomenon secondary to diagnosed collagen vascular disease. The patient, diagnosed as suffering from mixed connective tissue disease, had an average of 6.3 vasospastic attacks per day during a 2 week baseline period. The frequency of daily attacks dropped to 4.2 after 10 weeks and 2.5 attacks after 1 yr of training. In addition, the patient displayed a gradual improvement in the ability to maintain digital skin temperature in the presence of ambient cold stress.}, Doi = {10.1016/0005-7916(81)90013-6}, Key = {fds276375} } @article{fds305791, Author = {SURWIT, RS and ALLEN, LM and KUHN, CM and GILGOR, RS and DUVIC, M and SCHANBERG, SM and WILLIAMS, RB}, Title = {NEUROENDOCRINE CORRELATES OF RAYNAUDS DISEASE AND RAYNAUD PHENOMENON}, Journal = {Psychophysiology}, Volume = {18}, Number = {2}, Pages = {204-204}, Publisher = {SOC PSYCHOPHYSIOL RES}, Year = {1981}, Month = {January}, ISSN = {0048-5772}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1981LH49500214&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305791} } @article{fds305774, Author = {SURWIT, RS}, Title = {INDIVIDUAL-DIFFERENCES IN RESPONSE TO THE BEHAVIORAL TREATMENT OF RAYNAUD DISEASE}, Journal = {Psychophysiology}, Volume = {18}, Number = {2}, Pages = {200-201}, Publisher = {SOC PSYCHOPHYSIOL RES}, Year = {1981}, Month = {January}, ISSN = {0048-5772}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1981LH49500203&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305774} } @article{fds276404, Author = {Surwit, RS}, Title = {Behavioral approaches to Raynaud's disease.}, Journal = {Psychotherapy and Psychosomatics}, Volume = {36}, Number = {3-4}, Pages = {224-245}, Year = {1981}, ISSN = {0033-3190}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7345469}, Keywords = {Adult • Arousal • Autogenic Training • Behavior Therapy • Biofeedback (Psychology) • Female • Humans • Outcome and Process Assessment (Health Care) • Raynaud Disease • Skin • Skin Temperature • Vasoconstriction • Vasodilation • blood supply • methods* • psychology • therapy*}, Doi = {10.1159/000287546}, Key = {fds276404} } @article{fds305782, Author = {Surwit, RS}, Title = {Evaluation of Clinical Biofeedback}, Journal = {Psychosomatic Medicine}, Volume = {42}, Number = {3}, Pages = {379-380}, Publisher = {Ovid Technologies (Wolters Kluwer Health)}, Year = {1980}, Month = {May}, ISSN = {0033-3174}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1980KP45700009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Doi = {10.1097/00006842-198005000-00012}, Key = {fds305782} } @article{fds276416, Author = {Surwit, RS and Fenton, CH}, Title = {Feedback and instructions in the control of digital skin temperature.}, Journal = {Psychophysiology}, Volume = {17}, Number = {2}, Pages = {129-132}, Year = {1980}, Month = {March}, ISSN = {0048-5772}, url = {http://www.ncbi.nlm.nih.gov/pubmed/7375614}, Keywords = {Adult • Biofeedback (Psychology)* • Female • Fingers • Humans • Middle Aged • Raynaud Disease • Skin Temperature* • therapy*}, Doi = {10.1111/j.1469-8986.1980.tb00123.x}, Key = {fds276416} } @article{fds276348, Author = {Surwit, RS}, Title = {Biofeedback training in clinical cardiovascular disease}, Journal = {Primary Cardiology}, Volume = {6}, Number = {9}, Pages = {34-48}, Year = {1980}, Month = {January}, Abstract = {Biofeedback mechanisms have been shown to be effective in treating mild hypertension. Various forms include binary feedback training to lower blood pressure and heart rate, analogue feedback to control forearm and frontalis electromyographic activity, and meditation-relaxation procedures. The simple technique of having the patient take his own blood pressure and consciously attempt to lower it by whatever mechanism he can is quite effective. Thermal feedback training to control migraine headaches and Raynaud's disease has been successful. Autogenic training to control skin temperature is also an effective instrument.}, Key = {fds276348} } @article{fds305783, Author = {SURWIT, RS and GILGOR, RS and DUVIC, M and WILLIAMS, R and SCHANBERG, S and NEAL, J}, Title = {RAYNAUDS DISEASE - ROLE OF THE AUTONOMIC NERVOUS-SYSTEM IN PATHOGENESIS}, Journal = {Journal of Investigative Dermatology}, Volume = {75}, Number = {5}, Pages = {459-459}, Publisher = {BLACKWELL SCIENCE INC}, Year = {1980}, Month = {January}, ISSN = {0022-202X}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1980KQ62500019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305783} } @article{fds276353, Author = {Keefe, FJ and Surwit, RS and Pilon, RN}, Title = {Biofeedback, autogenic training, and progressive relaxation in the treatment of Raynaud's disease: a comparative study.}, Journal = {Journal of Applied Behavior Analysis}, Volume = {13}, Number = {1}, Pages = {3-11}, Year = {1980}, ISSN = {0021-8855}, url = {http://www.ncbi.nlm.nih.gov/pubmed/6988380}, Keywords = {Autogenic Training* • Biofeedback (Psychology)* • Cold • Female • Heart Rate • Humans • Raynaud Disease • Relaxation Techniques* • Skin Temperature • therapy*}, Abstract = {Twenty-one female patients suffering from diagnosed idiopathic Raynaud's Disease were trained to raise digital skin temperature using either autogenic training, progressive muscle relaxation, or a combination of autogenic training and skin temperature feedback. Patients were instructed in the treatment procedures in three one-hour group sessions spaced one week apart. All patients were instructed to practice what they had learned twice a day at home. Patients kept records of the frequency of vasospastic attacks occurring over a four-week baseline period, and during the first four weeks and the ninth week of training. In addition, patients underwent four laboratory cold stress tests during which they were instructed to maintain digital temperature as the ambient temperature was slowly dropped from 26 degrees to 17 degrees C. Cold stress tests were given during week 1 of baseline and during weeks 1, 3, and 5 of training. No significant differences between the three behavioral treatment procedures were obtained. In addition, the ability of patients to maintain digital temperature during the cold stress challenge showed significant improvement from the first to the last tests. Symptomatic improvement was maintained by all patients nine weeks after the start of training. The implications of these findings for the behavioral treatment of Raynaud's Disease are discussed.}, Doi = {10.1901/jaba.1980.13-3}, Key = {fds276353} } @article{fds276400, Author = {Keefe, FJ and Surwit, RS and Pilon, RN}, Title = {A 1-year follow-up of Raynaud's patients treated with behavioral therapy techniques.}, Journal = {Journal of Behavioral Medicine}, Volume = {2}, Number = {4}, Pages = {385-391}, Year = {1979}, Month = {December}, ISSN = {0160-7715}, url = {http://www.ncbi.nlm.nih.gov/pubmed/548581}, Keywords = {Adult • Autogenic Training* • Biofeedback (Psychology)* • Female • Fingers • Heart Rate • Humans • Middle Aged • Raynaud Disease • Skin Temperature • diagnosis • therapy*}, Abstract = {The purpose of this study was to assess to what degree learned control of digital temperature and vasospastic attacks can be retained by Raynaud's patients over a full year period. Subjects were 19 patients suffering from diagnosed idiopathic Raynaud's disease who had undergone behavioral training. These patients had been trained to increase digital temperature using either autogenic training, biofeedback, or a combination of autogenic training and temperature biofeedback. Results indicated that the mean number of vasospastic attacks per day occurring 1 year after training was approximately equal to the number occurring at the end of the initial training (1.2-1.3 per day). Patient satisfaction with the treatment program was above average (3.5 on a 5-point scale). The patients' ability to maintain digital temperature during the cold stress challenge was imparied, however. At 1-year follow-up, digital temperature readings taken in the laboratory were identical to baseline levels.}, Doi = {10.1007/BF00844742}, Key = {fds276400} } @article{fds276355, Author = {Surwit, RS and Bradner, MN and Fenton, CH and Pilon, RN}, Title = {Individual differences in response to the behavioral treatment of Raynaud's disease.}, Journal = {Journal of Consulting and Clinical Psychology}, Volume = {47}, Number = {2}, Pages = {363-367}, Year = {1979}, Month = {April}, ISSN = {0022-006X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/469084}, Keywords = {Adult • Autogenic Training • Behavior Therapy • Female • Humans • Individuality* • Middle Aged • Raynaud Disease • Skin Temperature • methods* • psychology • therapy*}, Doi = {10.1037//0022-006x.47.2.363}, Key = {fds276355} } @article{fds305781, Author = {SURWIT, RS and FENTON, CH}, Title = {ROLE OF VISUAL TEMPERATURE IN VOLUNTARY DIGITAL TEMPERATURE AUTO-REGULATION}, Journal = {Psychophysiology}, Volume = {16}, Number = {2}, Pages = {187-188}, Publisher = {CAMBRIDGE UNIV PRESS}, Year = {1979}, Month = {January}, ISSN = {0048-5772}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1979GN13600066&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305781} } @article{fds305780, Author = {SURWIT, RS}, Title = {BIOFEEDBACK - PRINCIPLES AND PRACTICE FOR CLINICIANS - BASMAJIAN,JV}, Journal = {Contemporary Psychology: a Journal of Reviews}, Volume = {24}, Number = {10}, Pages = {810-811}, Publisher = {AMER PSYCHOLOGICAL ASSOC}, Year = {1979}, Month = {January}, ISSN = {0010-7549}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1979HT09600058&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305780} } @article{fds276392, Author = {Surwit, RS and Pilon, RN and Fenton, CH}, Title = {Behavioral treatment of Raynaud's disease.}, Journal = {Journal of Behavioral Medicine}, Volume = {1}, Number = {3}, Pages = {323-335}, Year = {1978}, Month = {September}, ISSN = {0160-7715}, url = {http://www.ncbi.nlm.nih.gov/pubmed/755865}, Keywords = {Adult • Autogenic Training • Behavior Therapy • Biofeedback (Psychology) • Cold • Female • Generalization, Response • Humans • Middle Aged • Raynaud Disease • Skin Temperature • methods* • psychology • therapy*}, Abstract = {In order to assess the efficacy of a behavioral intervention in the treatment of idiopathic Raynaud's disease, 30 female patients were trained to control their digital skin temperature using autogenic training or a combination of autogenic training and skin temperature feedback either in the laboratory or at home. All trained subjects demonstrated a significant ability to maintain digital skin temperature in the presence of a cold stress challenge and reported significant reductions in both frequency and intensity of vasospastic attacks. The addition of skin temperature feedback to autogenic training did not provide additional clinical benefit.}, Doi = {10.1007/BF00846683}, Key = {fds276392} } @article{fds276394, Author = {Hager, JL and Surwit, RS}, Title = {Hypertension self-control with a portable feedback unit or meditation-relaxation.}, Journal = {Biofeedback and Self Regulation}, Volume = {3}, Number = {3}, Pages = {269-276}, Year = {1978}, Month = {September}, ISSN = {0363-3586}, url = {http://www.ncbi.nlm.nih.gov/pubmed/365249}, Keywords = {Adult • Biofeedback (Psychology)* • Blood Pressure • Blood Pressure Determination • Female • Humans • Hypertension • Male • Relaxation Techniques* • instrumentation* • therapy*}, Abstract = {Thirty borderline essential hypertensives were randomly assigned to a portable constant-cuff blood pressure feedback technique or meditation-relaxation. Each technique was taught in the laboratory, then practiced twice daily at home for four weeks. Subjects mailed daily records of their progress. Seven feedback and ten meditation-relaxation subjects completed the program. Both techniques produced significant systolic and diastolic reductions within practice sessions and diastolic reductions over weeks of training. Neither technique improved reductions nor reduced initial systolic pressure levels over the four weeks. Differences between biofeedback and meditation-relaxation in within-session pressure reductions were not significant.}, Doi = {10.1007/BF00999295}, Key = {fds276394} } @article{fds276368, Author = {Surwit, RS and Bradner, MN and Fenton, CH and Pilon, RN}, Title = {Laterality of body focus and digital skin temperature in patients with Raynaud's disease.}, Journal = {Psychophysiology}, Volume = {15}, Number = {4}, Pages = {320-323}, Year = {1978}, Month = {July}, ISSN = {0048-5772}, url = {http://www.ncbi.nlm.nih.gov/pubmed/693739}, Keywords = {Adult • Body Image* • Female • Functional Laterality • Hand • Humans • Middle Aged • Raynaud Disease • Skin Temperature* • Vasomotor System • blood supply • physiology* • physiopathology • psychology*}, Doi = {10.1111/j.1469-8986.1978.tb01386.x}, Key = {fds276368} } @article{fds276388, Author = {Surwit, RS and Shapiro, D and Good, MI}, Title = {Comparison of cardiovascular biofeedback, neuromuscular biofeedback, and meditation in the treatment of borderline essential hypertension.}, Journal = {Journal of Consulting and Clinical Psychology}, Volume = {46}, Number = {2}, Pages = {252-263}, Year = {1978}, Month = {April}, ISSN = {0022-006X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/348731}, Keywords = {Adult • Biofeedback (Psychology)* • Blood Pressure • Electromyography • Female • Heart Rate • Humans • Hypertension • Male • Methods • Middle Aged • Relaxation Techniques* • therapy*}, Doi = {10.1037//0022-006x.46.2.252}, Key = {fds276388} } @article{fds276406, Author = {Keefe, FJ and Surwit, RS}, Title = {Electromyographic biofeedback: behavioral treatment of neuromuscular disorders.}, Journal = {Journal of Behavioral Medicine}, Volume = {1}, Number = {1}, Pages = {13-24}, Year = {1978}, Month = {March}, ISSN = {0160-7715}, url = {http://www.ncbi.nlm.nih.gov/pubmed/556109}, Keywords = {Behavior Therapy • Biofeedback (Psychology)* • Bruxism • Cerebral Infarction • Electromyography • Humans • Neuromuscular Diseases • Outcome and Process Assessment (Health Care) • Poliomyelitis • Temporomandibular Joint Dysfunction Syndrome • Torticollis • Trauma, Nervous System • methods* • therapy • therapy*}, Abstract = {Electromyographic biofeedback is becoming widely used to help patients regain voluntary control of specific muscles affected by neuromuscular disorders. Electromyographic feedback training has been employed in the rehabilitation of patients affected by poliomyelitis, cerebrovascular accident, torticollis, nerve injury, temporomandibular joint syndrome, bruxism, and other disorders. While EMG biofeedback appears to be a promising treatment technique, the research literature on its effectiveness consists mainly of uncontrolled case reports and clinical trials. It is concluded that new studies with more sophisticated design and more careful control are needed to demonstrate that EMG biofeedback makes a unique contribution to the treatment of neuromuscular disorders. Research is needed to identify relevant patients characteristics predictive of success, specify appropriate muscle groups for the treatment of particular disorders, determine how feedback can be most efficiently combined with more conventional techniques in achieving a therapeutic effect, and establish meaningful criteria of success in the treatment of neuromuscular disorders.}, Doi = {10.1007/BF00846583}, Key = {fds276406} } @article{fds276350, Author = {Surwit, RS and Keefe, FJ}, Title = {Frontalis EMG feedback training: An electronic panacea?}, Journal = {Behavior Therapy}, Volume = {9}, Number = {5}, Pages = {779-792}, Publisher = {Elsevier BV}, Year = {1978}, Month = {January}, ISSN = {0005-7894}, url = {http://dx.doi.org/10.1016/S0005-7894(78)80008-2}, Abstract = {Studies dealing with the application of frontalis EMG feedback to the treatment of a variety of disorders are reveiwed. Successful applications of frontalis EMG feedback training have been reported in the treatment of muscle contraction headaches, asthma, essential hypertension, insomnia, chronic anxiety, phobias, and cerebral palsy. While available evidence does suggest that frontalis EMG feedback training may be helpful in the treatment of these disorders, these effects are equivalent but not superior to those that can be obtained using more conventional and less costly treatment techniques such as relaxation training. In addition, there appears to be a lack of clear rationale for the use of frontalis as a training site in treatment of these disorders. It is concluded that claims made about the clinical advantages of frontalis EMG biofeedback as compared to other methods of relaxation are not scientifically justified. © 1978 Association for Advancement of Behavior Therapy.}, Doi = {10.1016/S0005-7894(78)80008-2}, Key = {fds276350} } @article{fds305770, Author = {SURWIT, RS and PILON, RN and FENTON, CH}, Title = {BEHAVIORAL TREATMENT OF RAYNAUD DISEASE}, Journal = {Psychophysiology}, Volume = {15}, Number = {3}, Pages = {286-286}, Publisher = {CAMBRIDGE UNIV PRESS}, Year = {1978}, Month = {January}, ISSN = {0048-5772}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1978FB62300100&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305770} } @article{fds305775, Author = {SURWIT, RS}, Title = {WARMING THOUGHTS FOR A COLD WINTER}, Journal = {Psychology Today}, Volume = {12}, Number = {7}, Pages = {112-&}, Publisher = {PSYCHOLOGY TODAY}, Year = {1978}, Month = {January}, ISSN = {0033-3107}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1978FY51300042&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305775} } @article{fds276412, Author = {Surwit, RS}, Title = {Simple versus complex feedback displays in the training of digital temperature.}, Journal = {Journal of Consulting and Clinical Psychology}, Volume = {45}, Number = {1}, Pages = {146-147}, Year = {1977}, Month = {February}, ISSN = {0022-006X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/845299}, Keywords = {Acoustic Stimulation • Adolescent • Adult • Biofeedback (Psychology)* • Fingers • Humans • Male • Photic Stimulation • Reward • Skin Temperature* • physiology*}, Doi = {10.1037//0022-006x.45.1.146}, Key = {fds276412} } @article{fds305785, Author = {HAGER, JL and SURWIT, RS}, Title = {HYPERTENSION SELF-CONTROL WITH A PORTABLE FEEDBACK UNIT OR RELAXATION}, Journal = {Psychophysiology}, Volume = {14}, Number = {1}, Pages = {97-98}, Publisher = {CAMBRIDGE UNIV PRESS}, Year = {1977}, Month = {January}, ISSN = {0048-5772}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1977CU63200079&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305785} } @article{fds305771, Author = {SURWIT, RS and HAGER, JL and FELDMAN, T}, Title = {ROLE OF FEEDBACK IN VOLUNTARY CONTROL OF BLOOD-PRESSURE IN INSTRUCTED SUBJECTS}, Journal = {Psychophysiology}, Volume = {14}, Number = {1}, Pages = {97-97}, Publisher = {CAMBRIDGE UNIV PRESS}, Year = {1977}, Month = {January}, ISSN = {0048-5772}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1977CU63200078&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds305771} } @article{fds276395, Author = {Surwit, RS and Hager, JL and Feldman, T}, Title = {The role of feedback in voluntary control of blood pressure in instructed subjects.}, Journal = {Journal of Applied Behavior Analysis}, Volume = {10}, Number = {4}, Pages = {625-631}, Year = {1977}, ISSN = {0021-8855}, url = {http://www.ncbi.nlm.nih.gov/pubmed/599107}, Keywords = {Adolescent • Adult • Autogenic Training* • Biofeedback (Psychology)* • Blood Pressure* • Humans • Male • Methods • Reinforcement (Psychology) • Teaching}, Abstract = {Forty normal male volunteers were randomly assigned to one of four experimental conditions and instructed to raise and lower their systolic blood pressure. Subjects received either beat-to-beat feedback contingent on pressure changes, noncontingent beat-to-beat feedback, noncontingent feedback presented randomly with respect to the occurrence of each heart beat, or instructions alone. The order of increase and decrease trial blocks was counterbalanced across groups. Subjects receiving contingent feedback were monetarily rewarded for appropriate pressure changes. Subjects receiving noncontingent feedback received rewards and feedback equal to the mean received by the contingent group. Subjects in the instructions-only condition were also paid this bonus but were informed of their earnings only at the conclusion of the experiment. Results indicated that in the presence of instructions, feedback, whether contingent or noncontingent, added little to subjects' ability to control pressure during a single session. Theoretical and clinical implications are discussed.}, Doi = {10.1901/jaba.1977.10-625}, Key = {fds276395} } @article{fds276411, Author = {SURWIT, RS and SHAPIRO, D}, Title = {DIGITAL TEMPERATURE AUTOREGULATION AND ASSOCIATED CARDIOVASCULAR CHANGES}, Journal = {Psychophysiology}, Volume = {13}, Number = {2}, Pages = {165-165}, Publisher = {CAMBRIDGE UNIV PRESS}, Year = {1976}, Month = {January}, ISSN = {0048-5772}, url = {http://www.ncbi.nlm.nih.gov/pubmed/1273229}, Keywords = {Adolescent • Adult • Conditioning, Operant • Feedback • Female • Functional Laterality • Heart Rate* • Humans • Male • Pulse • Respiration • Reward • Sex Factors • Skin Temperature* • Temperature • physiology*}, Doi = {10.1111/j.1469-8986.1976.tb00106.x}, Key = {fds276411} } @article{fds276402, Author = {Surwit, RS and Poser, EG}, Title = {Latent inhibition in the conditioned electrodermal response.}, Journal = {Journal of Comparative and Physiological Psychology}, Volume = {86}, Number = {3}, Pages = {543-548}, Year = {1974}, Month = {March}, ISSN = {0021-9940}, url = {http://www.ncbi.nlm.nih.gov/pubmed/4814770}, Keywords = {Acoustic Stimulation • Adolescent • Adult • Animals • Attention • Conditioning, Classical* • Electroshock • Female • Galvanic Skin Response* • Humans • Inhibition (Psychology)* • Orientation • Photic Stimulation • Psychological Theory • Reaction Time • Research Design • Time Factors}, Doi = {10.1037/h0036133}, Key = {fds276402} } @article{fds276421, Author = {Shapiro, D and Surwit, RS}, Title = {Operant conditioning: a new theoretical approach in psychosomatic medicine.}, Journal = {International Journal of Psychiatry in Medicine}, Volume = {5}, Number = {4}, Pages = {377-387}, Year = {1974}, ISSN = {0091-2174}, url = {http://www.ncbi.nlm.nih.gov/pubmed/4618839}, Keywords = {Autogenic Training • Autonomic Nervous System • Behavior Therapy* • Conditioning, Operant* • Feedback • Generalization (Psychology) • Headache • Heart Rate • Humans • Hypertension • Motivation • Muscle Contraction • Paralysis • Psychophysiologic Disorders • Psychophysiology • Relaxation • Transfer (Psychology) • Yoga • physiology • rehabilitation • therapy • therapy*}, Doi = {10.2190/7EYM-L28K-FT5C-AG07}, Key = {fds276421} } @article{fds276424, Author = {Surwit, RS}, Title = {Biofeedback: a possible treatment for Raynaud's disease.}, Journal = {Seminars in Psychiatry}, Volume = {5}, Number = {4}, Pages = {483-490}, Year = {1973}, Month = {November}, ISSN = {0037-1971}, url = {http://www.ncbi.nlm.nih.gov/pubmed/4770576}, Keywords = {Adolescent • Adult • Autonomic Nervous System • Conditioning, Operant* • Feedback* • Female • Humans • Male • Middle Aged • Psychophysiologic Disorders • Raynaud Disease • Remission, Spontaneous • Skin Temperature • physiology • surgery • therapy • therapy*}, Key = {fds276424} } @article{fds305764, Author = {Finch, DM and Surwit, RS and Johnson, RR}, Title = {The effects of amygdalectomy on shock-induced fighting behavior in rats}, Journal = {Psychonomic Science}, Volume = {10}, Number = {11}, Pages = {369-370}, Publisher = {Springer Nature}, Year = {1968}, Month = {January}, ISSN = {0033-3131}, url = {http://dx.doi.org/10.3758/BF03331565}, Abstract = {Amygdaloid lesioned rats were compared to cortically lesioned and normal rats in their level of shock-induced fighting behavior. The resultant fighting scores, as rated on a four point scale, showed no significant difference in aggressive behavior on the part of the amygdalectomized group as compared to the cortical and normal control groups. Theoretical explanations of the results are proposed. © 1968, Psychonomic Journals. All rights reserved.}, Doi = {10.3758/BF03331565}, Key = {fds305764} } %% Chapters in Books @misc{fds366620, Author = {Surwit, RS}, Title = {Glycemic responsivity to adrenergic stimulation and genetic predisposition to type II diabetes}, Pages = {235-248}, Booktitle = {Stress and Disease Processes: Perspectives in Behavioral Medicine}, Year = {2018}, Month = {January}, ISBN = {0805811613}, url = {http://dx.doi.org/10.4324/9781315827490-13}, Abstract = {Since the 1980s, great strides have been made in the understanding of pathophysiology at the molecular level. Reverse genetic methods have been used to identify the mechanisms by which genetic defects cause a cascade of biochemical events leading to the development of disease. The promise of the molecular genetics has overshadowed much of the importance of conventional physiology and has shifted the focus of many scientists from the whole organism to microparticles. However, it is important to realize that ultimate potential of the molecular approach depends on a thorough understanding of how the organism functions in its environment. The reverse genetic methodology of molecular biology utilizes conventional genetics to map, localize, and clone genes related to disease. This approach is limited by our ability to identify individuals who show the phenotype of a particular disease. Diseases with "variable penetrance" are difficult to study genetically because the phenotype may not always be present in individuals who carry the genotype. One important lesson to come from behavioral medicine research is that many disease phenotypes result from the interaction of environmental stress and genetic predisposition. Acting through neuroendocrine pathways, stress disturbs the function of vulnerable end organ systems in predisposed individuals. This disturbance, if chronic, can lead to a permanent breakdown in function.}, Doi = {10.4324/9781315827490-13}, Key = {fds366620} } | |
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