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| Publications of Ilene C. Siegler :chronological alphabetical combined listing:
%% Journal Articles
@article{fds374927,
Author = {Andonian, BJ and Ross, LM and Sudnick, AM and Johnson, JL and Pieper,
CF and Belski, KB and Counts, JD and King, AP and Wallis, JT and Bennett,
WC and Gillespie, JC and Moertl, KM and Richard, D and Huebner, JL and Connelly, MA and Siegler, IC and Kraus, WE and Bales, CW and Porter
Starr, KN and Huffman, KM},
Title = {Effect of Remotely Supervised Weight Loss and Exercise
Training Versus Lifestyle Counseling on Cardiovascular Risk
and Clinical Outcomes in Older Adults With Rheumatoid
Arthritis: A Randomized Controlled Trial.},
Journal = {Acr Open Rheumatol},
Year = {2023},
Month = {December},
url = {http://dx.doi.org/10.1002/acr2.11639},
Abstract = {OBJECTIVE: To compare a remotely supervised weight loss and
exercise intervention to lifestyle counseling for effects on
cardiovascular disease risk, disease activity, and
patient-reported outcomes in older patients with rheumatoid
arthritis (RA) and overweight/obesity. METHODS: Twenty older
(60-80 years), previously sedentary participants with
seropositive RA and overweight/obesity were randomized to
16 weeks of either Supervised Weight loss and Exercise
Training (SWET) or Counseling Health As Treatment (CHAT).
The SWET group completed aerobic training (150 minutes/week
moderate-to-vigorous intensity), resistance training (two
days/week), and a hypocaloric diet (7% weight loss goal).
The CHAT control group completed two lifestyle counseling
sessions followed by monthly check-ins. The primary outcome
was a composite metabolic syndrome z-score (MSSc) derived
from fasting glucose, triglycerides, high density
lipoprotein-cholesterol, minimal waist circumference, and
mean arterial pressure. Secondary outcomes included RA
disease activity and patient-reported outcomes. RESULTS:
Both groups improved MSSc (absolute change -1.67 ± 0.64
in SWET; -1.34 ± 1.30 in CHAT; P < 0.01 for both
groups) with no between-group difference. Compared with
CHAT, SWET significantly improved body weight, fat mass,
Disease Activity Score-28 C-reactive protein, and
patient-reported physical health, physical function, mental
health, and fatigue (P < 0.04 for all between-group
comparisons). Based on canonical correlations for fat mass,
cardiorespiratory fitness, and leg strength,
component-specific effects were strongest for (1) weight
loss improving MSSc, physical health, and mental health; (2)
aerobic training improving physical function and fatigue;
and (3) resistance training improving Disease Activity
Score-28 C-reactive protein. CONCLUSION: In older patients
with RA and overweight/obesity, 16 weeks of remotely
supervised weight loss, aerobic training, and resistance
training improve cardiometabolic health, patient-reported
outcomes, and disease activity. Less intensive lifestyle
counseling similarly improves cardiovascular disease risk
profiles, suggesting an important role for integrative
interventions in the routine clinical care of this at-risk
RA population.},
Doi = {10.1002/acr2.11639},
Key = {fds374927}
}
@article{fds370527,
Author = {Andonian, B and Ross, LM and Zidek, AM and Fos, LB and Piner, LW and Johnson, JL and Belski, KB and Counts, JD and Pieper, CF and Siegler,
IC and Bales, CW and Porter Starr and KN and Kraus, WE and Huffman,
KM},
Title = {Remotely Supervised Weight Loss and Exercise Training to
Improve Rheumatoid Arthritis Cardiovascular Risk: Rationale
and Design of the Supervised Weight Loss Plus Exercise
Training-Rheumatoid Arthritis Trial.},
Journal = {Acr Open Rheumatol},
Volume = {5},
Number = {5},
Pages = {252-263},
Year = {2023},
Month = {May},
url = {http://dx.doi.org/10.1002/acr2.11536},
Abstract = {Patients with rheumatoid arthritis (RA) remain at an
increased risk for cardiovascular disease (CVD) and
mortality. RA CVD results from a combination of traditional
risk factors and RA-related systemic inflammation. One
hypothetical means of improving overall RA CVD risk is
through reduction of excess body weight and increased
physical activity. Together, weight loss and physical
activity can improve traditional cardiometabolic health
through fat mass loss, while also improving skeletal muscle
health. Additionally, disease-related CVD risk may improve
as both fat mass loss and exercise reduce systemic
inflammation. To explore this hypothesis, 26 older persons
with RA and overweight/obesity will be randomized to
16 weeks of a usual care control arm or to a remotely
Supervised Weight Loss Plus Exercise Training (SWET)
program. A caloric restriction diet (targeting 7% weight
loss) will occur via a dietitian-led intervention, with
weekly weigh-ins and group support sessions. Exercise
training will consist of both aerobic training (150
minutes/week moderate-to-vigorous exercise) and resistance
training (twice weekly). The SWET remote program will be
delivered via a combination of video conference, the study
YouTube channel, and study mobile applications. The primary
cardiometabolic outcome is the metabolic syndrome Z score,
calculated from blood pressure, waist circumference,
high-density lipoprotein cholesterol, triglycerides, and
glucose. RA-specific CVD risk will be assessed with measures
of systemic inflammation, disease activity, patient-reported
outcomes, and immune cell function. The SWET-RA trial will
be the first to assess whether a remotely supervised,
combined lifestyle intervention improves cardiometabolic
health in an at-risk population of older individuals with RA
and overweight/obesity.},
Doi = {10.1002/acr2.11536},
Key = {fds370527}
}
@article{fds371488,
Author = {Collins, KA and Huffman, KM and Wolever, RQ and Smith, PJ and Ross, LM and Siegler, IC and Jakicic, JM and Costa, PT and Kraus,
WE},
Title = {Demographic, Clinical, and Psychosocial Predictors of
Exercise Adherence: The STRRIDE Trials.},
Journal = {Translational Journal of the American College of Sports
Medicine},
Volume = {8},
Number = {3},
Year = {2023},
url = {http://dx.doi.org/10.1249/tjx.0000000000000229},
Abstract = {PURPOSE: To identify baseline demographic, clinical, and
psychosocial predictors of exercise intervention adherence
in the Studies of a Targeted Risk Reduction Intervention
through Defined Exercise (STRRIDE) trials. METHODS: A total
of 947 adults with dyslipidemia or prediabetes were enrolled
into an inactive control group or one of ten exercise
interventions with doses of 10-23 kcal/kg/week, intensities
of 40-80% of peak oxygen consumption, and training for
6-8-months. Two groups included resistance training. Mean
percent aerobic and resistance adherence were calculated as
the amount completed divided by the prescribed weekly
minutes or total sets of exercise times 100, respectively.
Thirty-eight clinical, demographic, and psychosocial
measures were considered for three separate models: 1)
clinical + demographic factors, 2) psychosocial factors, and
3) all measures. A backward bootstrapped variable selection
algorithm and multiple regressions were performed for each
model. RESULTS: In the clinical and demographic measures
model (n=947), variables explained 16.7% of the variance in
adherence (p<0.001); lesser fasting glucose explained the
greatest amount of variance (partial R2 = 3.2%). In the
psychosocial factors model (n=561), variables explained
19.3% of the variance in adherence (p<0.001); greater
36-Item Short Form Health Survey (SF-36) physical component
score explained the greatest amount of variance (partial R2
= 8.7%). In the model with all clinical, demographic, and
psychosocial measures (n=561), variables explained 22.1% of
the variance (p<0.001); greater SF-36 physical component
score explained the greatest amount of variance (partial R2
= 8.9%). SF-36 physical component score was the only
variable to account for >5% of the variance in adherence in
any of the models. CONCLUSIONS: Baseline demographic,
clinical, and psychosocial variables explain approximately
22% of the variance in exercise adherence. The limited
variance explained suggests future research should
investigate additional measures to better identify
participants who are at risk for poor exercise intervention
adherence.},
Doi = {10.1249/tjx.0000000000000229},
Key = {fds371488}
}
@article{fds372235,
Author = {Collins, KA and Huffman, KM and Wolever, RQ and Smith, PJ and Siegler,
IC and Ross, LM and Jakicic, JM and Costa, PT and Kraus,
WE},
Title = {Race and sex differences in dropout from the STRRIDE
trials.},
Journal = {Frontiers in Sports and Active Living},
Volume = {5},
Pages = {1215704},
Year = {2023},
url = {http://dx.doi.org/10.3389/fspor.2023.1215704},
Abstract = {PURPOSE: To determine if race and sex differences exist in
determinants and timing of dropout among individuals
enrolled in an exercise and/or caloric restriction
intervention. METHODS: A total of 947 adults with
dyslipidemia (STRRIDE I, STRRIDE AT/RT) or prediabetes
(STRRIDE-PD) were randomized to either inactive control or
to 1 of 10 exercise interventions, ranging from doses of
8-23 kcal/kg/week, intensities of 50%-75% V˙O2 peak, and
durations of 6-8 months. Two groups included resistance
training, and one included a dietary intervention (7% weight
loss goal). Dropout was defined as an individual withdrawn
from the study, with the reasons for dropout aggregated into
determinant categories. Timing of dropout was defined as the
last session attended and aggregated into phases (i.e.,
"ramp" period to allow gradual adaptation to exercise
prescription). Utilizing descriptive statistics, percentages
were generated according to categories of determinants and
timing of dropout to describe the proportion of individuals
who fell within each category. RESULTS: Black men and women
were more likely to be lost to follow-up (Black men: 31.3%
and Black women: 19.6%), or dropout due to work
responsibilities (15.6% and 12.5%), "change of mind" (12.5%
and 8.9%), transportation issues (6.3% and 3.6%), or
reported lack of motivation (6.3% and 3.6%). Women in
general noted lack of time more often than men as a reason
for dropout (White women: 22.4% and Black women: 22.1%).
Regardless of race and sex, most participants dropped out
during the ramp period of the exercise intervention; with
Black women (50%) and White men (37.1%) having the highest
dropout rate during this period. CONCLUSION: These findings
emphasize the importance of targeted retention strategies
when aiming to address race and sex differences that exist
in determinants and timing of dropout among individuals
enrolled in an exercise and/or caloric restriction
intervention.},
Doi = {10.3389/fspor.2023.1215704},
Key = {fds372235}
}
@article{fds362115,
Author = {Collins, KA and Ross, LM and Piner, LW and Fos, LB and Slentz, CA and Bateman, LA and Willis, LH and Bales, CW and Siegler, IC and Wolever,
RQ and Huffman, KM and Kraus, WE},
Title = {Amount and intensity effects of exercise training alone
versus a combined diet and exercise lifestyle intervention
on health-related quality of life in the STRRIDE-PD
randomized trial.},
Journal = {Bmj Open Diabetes Research & Care},
Volume = {10},
Number = {1},
Year = {2022},
Month = {January},
url = {http://dx.doi.org/10.1136/bmjdrc-2021-002584},
Abstract = {INTRODUCTION: To determine the relative contributions of
various amounts and intensities of exercise alone to a
combined lifestyle intervention on health-related quality of
life (HrQoL) measures. RESEARCH DESIGN AND METHODS:
Participants (n=162) were sedentary, overweight/obese, with
pre-diabetes, and randomized to one of four 6-month
interventions: (1) high amount/moderate intensity
exercise-energy expenditure of 16 kcal/kg of body
weight/week (KKW) at 50% oxygen consumption (V̇O2) reserve;
(2) high/vigorous-16 KKW at 75% V̇O2 reserve; (3)
low/moderate-10 KKW at 50% V̇O2 reserve; (4) low/moderate
plus diet-10 KKW at 50% V̇O2 reserve plus a calorically
restricted diet. The 36-Item Short-Form Survey (SF-36) and
Satisfaction with Physical Function and Appearance (SPF/SPA)
survey were assessed at baseline and post-intervention.
Analyses of covariance determined differences in change
scores among groups (p<0.05). Paired t-tests determined
significant pre-intervention versus post-intervention scores
within groups (p<0.05). RESULTS: Across the intervention,
all groups (p<0.05) improved the physical component, SPF,
and SPA scores. Only the low/moderate/diet group (p<0.001)
significantly improved the mental component score. The
high/vigorous group achieved 84.5% of the low/moderate/diet
group effect for change in physical component score, and the
low/moderate group achieved 83.7% of the low/moderate/diet
group effect for change in mental component score.
CONCLUSIONS: In general, a low amount of moderate intensity
exercise combined with diet was the most effective
intervention for improving HrQoL. Of the exercise-only
interventions, vigorous intensity exercise provided the
greatest impact on changes in physical function. On the
other hand, low amounts of moderate intensity exercise
provided the greatest impact on mental well-being,
potentially being a more attainable exercise dose for
previously sedentary individuals with pre-diabetes to
achieve.},
Doi = {10.1136/bmjdrc-2021-002584},
Key = {fds362115}
}
@article{fds374443,
Author = {Collins, KA and Huffman, KM and Wolever, RQ and Smith, PJ and Siegler,
IC and Ross, LM and Hauser, ER and Jiang, R and Jakicic, JM and Costa, PT and Kraus, WE},
Title = {Determinants of Dropout from and Variation in Adherence to
an Exercise Intervention: The STRRIDE Randomized
Trials.},
Journal = {Translational Journal of the American College of Sports
Medicine},
Volume = {7},
Number = {1},
Year = {2022},
url = {http://dx.doi.org/10.1249/tjx.0000000000000190},
Abstract = {PURPOSE: This study aimed to characterize the timing and
self-reported determinants of exercise dropout among
sedentary adults with overweight or obesity. We also sought
to explore variations in adherence among individuals who
completed a 6- to 8-month structured exercise intervention.
METHODS: A total of 947 adults with dyslipidemia [STRRIDE I,
STRRIDE AT/RT] or prediabetes [STRRIDE-PD] were enrolled to
either control or to one of 10 exercise interventions,
ranging from doses of 8-23 kcal/kg/week; intensities of
50%-75% V̇O2 peak; and durations of 6-8 months. Two groups
included resistance training and one included dietary
intervention (7% weight loss goal). Dropout was defined as
an individual who withdrew from the study due a variety of
determinants. Timing of intervention dropout was defined as
the last session attended and categorized into phases.
Exercise training adherence was calculated by dividing
weekly minutes or total sets of exercise completed by weekly
minutes or total sets of exercise prescribed. General linear
models were used to characterize the associations between
timing of dropout and determinant category. RESULTS:
Compared to exercise intervention completers (n=652),
participants who dropped out (n=295) were on average
non-white (98% vs. 80%, p<0.01), had higher body mass index
(31.0 kg/m2 vs. 30.2 kg/m2; p<0.01), and were less fit at
baseline (25.0 mg/kg/min vs. 26.7 ml/kg/min, p<0.01). Of
those who dropped out, 67% did so prior to the start of or
while ramping up to the prescribed exercise volume and
intensity. The most commonly reported reason for dropout was
lack of time (40%). Notably, among individuals who completed
the ramp training period, subsequent exercise intervention
adherence did not waiver over the ensuing 6-8 months of
training. CONCLUSION: These findings are some of the first
to delineate associations between the timing of dropout and
dropout determinants, providing guidance to future exercise
interventions to better support individuals at-risk for
dropout.},
Doi = {10.1249/tjx.0000000000000190},
Key = {fds374443}
}
@article{fds357277,
Author = {Reavis, ZW and Mirjankar, N and Sarangi, S and Boyle, SH and Kuhn, CM and Matson, WR and Babyak, MA and Matson, SA and Siegler, IC and Kaddurah-Daouk, R and Suarez, EC and Williams, RB and Grichnik, K and Stafford-Smith, M and Georgiades, A},
Title = {Correction to: Sex and race differences of cerebrospinal
fluid metabolites in healthy individuals.},
Journal = {Metabolomics},
Volume = {17},
Number = {6},
Pages = {56},
Year = {2021},
Month = {June},
url = {http://dx.doi.org/10.1007/s11306-021-01809-z},
Doi = {10.1007/s11306-021-01809-z},
Key = {fds357277}
}
@article{fds354178,
Author = {Brummett, BH and Muller, CL and Collins, AL and Boyle, SH and Kuhn, CM and Siegler, IC and Williams, RB and Suarez, EC and Ashley-Koch,
A},
Title = {Correction to: 5-HTTLPR and Gender Moderate Changes in
Negative Affect Responses to Tryptophan Infusion.},
Journal = {Behav Genet},
Volume = {51},
Number = {2},
Pages = {163},
Year = {2021},
Month = {March},
url = {http://dx.doi.org/10.1007/s10519-020-10030-y},
Abstract = {© 2020, Springer Science+Business Media, LLC, part of
Springer Nature. After the publication of original article,
the Editor was notified by Duke University that they have
determined the authorship to be incomplete. Consequently,
Dr. Edward Suarez has been added as a co-author to this
article to represent his contribution to the conception and
design of the work and acquisition of the
data.},
Doi = {10.1007/s10519-020-10030-y},
Key = {fds354178}
}
@article{fds354287,
Author = {Brummett, BH and Boyle, SH and Siegler, IC and Kuhn, CM and Ashley-Koch,
A and Jonassaint, CR and Züchner, S and Collins, A and Suarez, EC and Williams, RB},
Title = {Correction to: Effects of Environmental Stress and Gender on
Associations among Symptoms of Depression and the Serotonin
Transporter Gene Linked Polymorphic Region
(5-HTTLPR).},
Journal = {Behav Genet},
Volume = {51},
Number = {2},
Pages = {162},
Year = {2021},
Month = {March},
url = {http://dx.doi.org/10.1007/s10519-020-10029-5},
Doi = {10.1007/s10519-020-10029-5},
Key = {fds354287}
}
@article{fds355174,
Author = {Reavis, ZW and Mirjankar, N and Sarangi, S and Boyle, SH and Kuhn, CM and Matson, WR and Babyak, MA and Matson, SA and Siegler, IC and Kaddurah-Daouk, R and Suarez, EC and Williams, RB and Grichnik, K and Stafford-Smith, M and Georgiades, A},
Title = {Sex and race differences of cerebrospinal fluid metabolites
in healthy individuals.},
Journal = {Metabolomics},
Volume = {17},
Number = {2},
Pages = {13},
Year = {2021},
Month = {January},
url = {http://dx.doi.org/10.1007/s11306-020-01757-0},
Abstract = {INTRODUCTION: Analyses of cerebrospinal fluid (CSF)
metabolites in large, healthy samples have been limited and
potential demographic moderators of brain metabolism are
largely unknown. OBJECTIVE: Our objective in this study was
to examine sex and race differences in 33 CSF metabolites
within a sample of 129 healthy individuals (37 African
American women, 29 white women, 38 African American men, and
25 white men). METHODS: CSF metabolites were measured with a
targeted electrochemistry-based metabolomics platform. Sex
and race differences were quantified with both univariate
and multivariate analyses. Type I error was controlled for
by using a Bonferroni adjustment (0.05/33 = .0015).
RESULTS: Multivariate Canonical Variate Analysis (CVA) of
the 33 metabolites showed correct classification of sex at
an average rate of 80.6% and correct classification of race
at an average rate of 88.4%. Univariate analyses revealed
that men had significantly higher concentrations of cysteine
(p < 0.0001), uric acid (p < 0.0001), and
N-acetylserotonin (p = 0.049), while women had
significantly higher concentrations of 5-hydroxyindoleacetic
acid (5-HIAA) (p = 0.001). African American participants
had significantly higher concentrations of
3-hydroxykynurenine (p = 0.018), while white
participants had significantly higher concentrations of
kynurenine (p < 0.0001), indoleacetic acid
(p < 0.0001), xanthine (p = 0.001), alpha-tocopherol
(p = 0.007), cysteine (p = 0.029), melatonin
(p = 0.036), and 7-methylxanthine (p = 0.037).
After the Bonferroni adjustment, the effects for cysteine,
uric acid, and 5-HIAA were still significant from the
analysis of sex differences and kynurenine and indoleacetic
acid were still significant from the analysis of race
differences. CONCLUSION: Several of the metabolites assayed
in this study have been associated with mental health
disorders and neurological diseases. Our data provide some
novel information regarding normal variations by sex and
race in CSF metabolite levels within the tryptophan,
tyrosine and purine pathways, which may help to enhance our
understanding of mechanisms underlying sex and race
differences and potentially prove useful in the future
treatment of disease.},
Doi = {10.1007/s11306-020-01757-0},
Key = {fds355174}
}
@article{fds351217,
Author = {Jonassaint, CR and Siegler, IC and Barefoot, JC and Edwards, CL and Suarez, EC and Williams, RB},
Title = {Correction to: Low Life Course Socioeconomic Status (SES) Is
Associated with Negative NEO PI-R Personality
Patterns.},
Journal = {International Journal of Behavioral Medicine},
Volume = {27},
Number = {6},
Pages = {737},
Year = {2020},
Month = {December},
url = {http://dx.doi.org/10.1007/s12529-020-09923-3},
Abstract = {After the publication of the original article, the Editor
was notified by Duke University that they have determined
the authorship to be incomplete. Consequently, Dr Edward
Suarez has been added as a co-author to represent his
contribution to the conception and design of the work and
acquisition of the data.},
Doi = {10.1007/s12529-020-09923-3},
Key = {fds351217}
}
@article{fds352414,
Author = {Jiang, R and Babyak, MA and Brummett, BH and Siegler, IC and Kuhn, CM and Williams, RB},
Title = {Corrigendum to "Brain-derived neurotrophic factor (BDNF)
Val66Met polymorphism interacts with gender to influence
cortisol responses to mental stress" [Psychoneuroendocrinology
79 (2017) (May) 13-19].},
Journal = {Psychoneuroendocrinology},
Volume = {121},
Pages = {104861},
Year = {2020},
Month = {November},
url = {http://dx.doi.org/10.1016/j.psyneuen.2020.104861},
Doi = {10.1016/j.psyneuen.2020.104861},
Key = {fds352414}
}
@article{fds352832,
Author = {Singh, A and Babyak, MA and Sims, M and Musani, SK and Brummett, BH and Jiang, R and Kraus, WE and Shah, SH and Siegler, IC and Hauser, ER and Williams, RB},
Title = {Evaluating the precision of EBF1 SNP x stress interaction
association: sex, race, and age differences in a big
harmonized data set of 28,026 participants.},
Journal = {Translational Psychiatry},
Volume = {10},
Number = {1},
Pages = {351},
Year = {2020},
Month = {October},
url = {http://dx.doi.org/10.1038/s41398-020-01028-5},
Abstract = {In prior work, we identified a novel gene-by-stress
association of EBF1's common variation (SNP rs4704963) with
obesity (i.e., hip, waist) in Whites, which was further
strengthened through multiple replications using our
synthetic stress measure. We now extend this prior work in a
precision medicine framework to find the risk group using
harmonized data from 28,026 participants by evaluating the
following: (a) EBF1 SNPxSTRESS interaction in Blacks; (b)
3-way interaction of EBF1 SNPxSTRESS with sex, race, and
age; and (c) a race and sex-specific path linking EBF1 and
stress to obesity to fasting glucose to the development of
cardiometabolic disease risk. Our findings provided
additional confirmation that genetic variation in EBF1 may
contribute to stress-induced human obesity, including in
Blacks (P = 0.022) that mainly resulted from
race-specific stress due to "racism/discrimination"
(P = 0.036) and "not meeting basic needs"
(P = 0.053). The EBF1 gene-by-stress interaction
differed significantly (P = 1.01e-03) depending on the
sex of participants in Whites. Race and age also showed
tentative associations (Ps = 0.103, 0.093, respectively)
with this interaction. There was a significant and
substantially larger path linking EBF1 and stress to obesity
to fasting glucose to type 2 diabetes for the EBF1 minor
allele group (coefficient = 0.28, P = 0.009, 95%
CI = 0.07-0.49) compared with the same path for the EBF1
major allele homozygotes in White females and also a similar
pattern of the path in Black females. Underscoring the
race-specific key life-stress indicators (e.g.,
racism/discrimination) and also the utility of our synthetic
stress, we identified the potential risk group of EBF1 and
stress-induced human obesity and cardiometabolic
disease.},
Doi = {10.1038/s41398-020-01028-5},
Key = {fds352832}
}
@article{fds349212,
Author = {Calland, AR and Siegler, IC and Costa, PT and Ross, LM and Zucker, N and French, R and Hauser, E and Huffman, KM},
Title = {Associations of self-reported eating disorder behaviors and
personality in a college-educated sample.},
Journal = {Appetite},
Volume = {151},
Pages = {104669},
Year = {2020},
Month = {August},
url = {http://dx.doi.org/10.1016/j.appet.2020.104669},
Abstract = {OBJECTIVE: In order to better understand factors motivating
eating disorder (ED) behaviors and better identify persons
at-risk for these behaviors, we sought to identify which
personality domains and facets were associated with
behaviors for weight control. METHODS: ED behavior
information was gathered from the University of North
Carolina Alumni Heart Study using the question, "have you
ever used any of the following to lose weight?" Respondents
endorsed any combination of the following: "Vomiting,"
"Fasting," "Laxatives," "Excessive physical exercise."
Personality was measured using the Revised NEO Personality
Inventory (NEO-PI-R). One-way ANOVAs were performed
comparing personality domains and facets to reported ED
behaviors, computed both as separate behaviors and the
number of cumulative behaviors. RESULTS: Of 3496
respondents, 9.41% endorsed ever having used at least one ED
behavior, with the majority endorsing only a single ED
behavior. For both sexes, endorsing greater numbers of ED
behaviors was associated with higher scores on Neuroticism
and Openness. For women, the strongest associations for
behaviors with personality were: excessive exercise with
high Impulsiveness; fasting with high Impulsiveness and low
Gregariousness; laxative use/purging with high scores on
Activity and Feelings. For men, the strongest associations
were: excessive exercise with high Impulsiveness; fasting
with high Ideas; laxative use/purging with low Modesty.
DISCUSSION: Data collected from this sample showed a
sex-modulated pattern of association between personality
domains and facets with ED behaviors. Our findings support
that obtaining personality profiles of individuals
exhibiting subclinical eating behaviors will enhance our
understanding of who is at risk of developing an ED
diagnosis.},
Doi = {10.1016/j.appet.2020.104669},
Key = {fds349212}
}
@article{fds347366,
Author = {Brummett, BH and Boyle, SH and Kuhn, CM and Siegler, IC and Suarez, EC and Williams, RB},
Title = {Corrigendum to "Socioeconomic status moderates associations
between CNS serotonin and expression of beta2-integrins
CD11b and CD11c" [J. Psychiatr Res. (2010)
44:373-377].},
Journal = {J Psychiatr Res},
Volume = {126},
Pages = {142},
Year = {2020},
Month = {July},
url = {http://dx.doi.org/10.1016/j.jpsychires.2019.11.003},
Doi = {10.1016/j.jpsychires.2019.11.003},
Key = {fds347366}
}
@article{fds348812,
Author = {Surwit, RS and Williams, RB and Siegler, IC and Lane, JD and Helms, M and Applegate, KL and Zucker, N and Feinglos, MN and McCaskill, CM and Barefoot, JC},
Title = {Erratum. Hostility, race, and glucose metabolism in
nondiabetic individuals. Diabetes Care 2002;25:835-839.},
Journal = {Diabetes Care},
Volume = {43},
Number = {3},
Pages = {691},
Year = {2020},
Month = {March},
url = {http://dx.doi.org/10.2337/dc20-er03},
Doi = {10.2337/dc20-er03},
Key = {fds348812}
}
@article{fds346731,
Author = {Brummett, BH and Babyak, MA and Jiang, R and Huffman, KM and Kraus, WE and Singh, A and Hauser, ER and Siegler, IC and Williams,
RB},
Title = {Systolic Blood Pressure and Socioeconomic Status in a large
multi-study population.},
Journal = {Ssm Population Health},
Volume = {9},
Pages = {100498},
Year = {2019},
Month = {December},
url = {http://dx.doi.org/10.1016/j.ssmph.2019.100498},
Abstract = {The present study used harmonized data from eight studies
(N = 28,891) to examine the association between
socioeconomic status (SES) and resting systolic blood
pressure (SBP). The study replicates and extends our prior
work on this topic by examining potential moderation of this
association by race and gender. We also examined the extent
to which body mass index (BMI), waist circumference (WC),
and smoking might explain the association between SES and
SBP. Data were available from six race/gender groups: 9200
Black women; 2337 Black men; 7248 White women; 6519 White
men; 2950 Hispanic women; and 637 Hispanic men.
Multivariable regression models showed that greater annual
household income was associated with lower SBP in all groups
except Hispanic men. The magnitude and form of this negative
association differed across groups, with White women showing
the strongest linear negative association. Among Black men
and Hispanic women, the association was curvilinear:
relatively flat among lower income levels, but then negative
among higher income ranges. Education also was
independently, negatively related to SBP, though evidence
was weaker for race and gender differences in the strength
of the association. Higher BMI and WC were associated with
higher SBP, and current smoking with lower SBP. Inclusion of
these risk factors resulted in only a modest change in the
magnitude of the SBP and SES relation, accounting on average
about 0.4 mmHg of the effect of income and 0.2 mmHg of
the effect of education-effects unlikely to be clinically
significant. Further understanding of mechanisms underlying
the association between SBP and SES may improve risk
stratification in clinical settings and potentially inform
interventions aimed at reductions in social disparities in
health.},
Doi = {10.1016/j.ssmph.2019.100498},
Key = {fds346731}
}
@article{fds346905,
Author = {Abdulrahim, JW and Kwee, LC and Grass, E and Siegler, IC and Williams,
R and Karra, R and Kraus, WE and Gregory, SG and Shah,
SH},
Title = {Epigenome-Wide Association Study for All-Cause Mortality in
a Cardiovascular Cohort Identifies Differential Methylation
in Castor Zinc Finger 1 (CASZ1).},
Journal = {Journal of the American Heart Association},
Volume = {8},
Number = {21},
Pages = {e013228},
Year = {2019},
Month = {November},
url = {http://dx.doi.org/10.1161/JAHA.119.013228},
Abstract = {Background DNA methylation is implicated in many chronic
diseases and may contribute to mortality. Therefore, we
conducted an epigenome-wide association study (EWAS) for
all-cause mortality with whole-transcriptome data in a
cardiovascular cohort (CATHGEN [Catheterization Genetics]).
Methods and Results Cases were participants with
mortality≥7 days postcatheterization whereas controls
were alive with≥2 years of follow-up. The Illumina Human
Methylation 450K and EPIC arrays (Illumina, San Diego, CA)
were used for the discovery and validation sets,
respectively. A linear model approach with empirical Bayes
estimators adjusted for confounders was used to assess
difference in methylation (Δβ). In the discovery set (55
cases, 49 controls), 25 629 (6.5%) probes were differently
methylated (P<0.05). In the validation set (108 cases, 108
controls), 3 probes were differentially methylated with a
false discovery rate-adjusted P<0.10: cg08215811 (SLC4A9;
log2 fold change=-0.14); cg17845532 (MATK; fold
change=-0.26); and cg17944110 (castor zinc finger 1 [CASZ1];
FC=0.26; P<0.0001; false discovery rate-adjusted
P=0.046-0.080). Meta-analysis identified 6 probes (false
discovery rate-adjusted P<0.05): the 3 above, cg20428720
(intergenic), cg17647904 (NCOR2), and cg23198793 (CAPN3).
Messenger RNA expression of 2 MATK isoforms was lower in
cases (fold change=-0.24 [P=0.007] and fold change=-0.61
[P=0.009]). The CASZ1, NCOR2, and CAPN3 transcripts did not
show differential expression (P>0.05); the SLC4A9 transcript
did not pass quality control. The cg17944110 probe is
located within a potential regulatory element; expression of
predicted targets (using GeneHancer) of the regulatory
element, UBIAD1 (P=0.01) and CLSTN1 (P=0.03), were lower in
cases. Conclusions We identified 6 novel methylation sites
associated with all-cause mortality. Methylation in CASZ1
may serve as a regulatory element associated with mortality
in cardiovascular patients. Larger studies are necessary to
confirm these observations.},
Doi = {10.1161/JAHA.119.013228},
Key = {fds346905}
}
@article{fds339673,
Author = {Do, EK and Haberstick, BC and Williams, RB and Lessem, JM and Smolen, A and Siegler, IC and Fuemmeler, BF},
Title = {The role of genetic and environmental influences on the
association between childhood ADHD symptoms and
BMI.},
Journal = {Int J Obes (Lond)},
Volume = {43},
Number = {1},
Pages = {33-42},
Year = {2019},
Month = {January},
url = {http://dx.doi.org/10.1038/s41366-018-0236-5},
Abstract = {BACKGROUND/OBJECTIVES: Although childhood attention deficit
hyperactivity disorder (ADHD) has been previously associated
with concurrent and later obesity in adulthood, the etiology
of this association remains unclear. The objective of this
study is to determine the shared genetic effects of ADHD
symptoms and BMI in a large sample of sibling pairs,
consider how these shared effects may vary over time, and
examine potential sex differences. SUBJECT/METHODS: Sibling
pair data were obtained from the National Longitudinal Study
of Adolescent to Adult Health (Add Health); childhood ADHD
symptoms were reported retrospectively during young
adulthood, while three prospective measurements of BMI were
available from young adulthood to later adulthood. Cholesky
decomposition models were fit to this data using Mx and
maximum-likelihood estimation. The twin and sibling sample
for these analyses included: 221 monozygotic (MZ) pairs (92
male-male, 139 female-female), 228 dizygotic (DZ) pairs (123
male-male, 105 female-female), 471 full-sibling (FS) pairs
(289 male-male, 182 female-female), 106 male-female DZ twin
pairs, and 234 male-female FS pairs. RESULTS: The magnitude
of the association between childhood ADHD symptoms and BMI
changed over time and by sex. The etiological relationship
between childhood ADHD symptoms and the three prospective
measurements of BMI differed for males and females, such
that unique or non-shared environmental influences
contributed to the relationship within males and genetic
factors contributed to the relationship within females.
Specifically, among females, genetic influences on childhood
ADHD symptoms were partially shared with those effecting BMI
and increased from adolescence to later adulthood (genetic
correlation = 0.20 (95% CI: 0.07-0.36) in adolescence
and 0.24 (95% CI: 0.10, 0.41) in adulthood). CONCLUSION:
Genetic influences on ADHD symptoms in childhood are
partially shared with those effecting obesity. However,
future research is needed to determine why this association
is limited to females.},
Doi = {10.1038/s41366-018-0236-5},
Key = {fds339673}
}
@article{fds340487,
Author = {Boyle, SH and Brummett, BH and Kuhn, CM and Barefoot, JC and Siegler,
IC and Williams, RB and Georgiades, A},
Title = {The Effects of Tryptophan Enhancement and Depletion on
Plasma Catecholamine Levels in Healthy Individuals.},
Journal = {Psychosom Med},
Volume = {81},
Number = {1},
Pages = {34-40},
Year = {2019},
Month = {January},
url = {http://dx.doi.org/10.1097/PSY.0000000000000637},
Abstract = {OBJECTIVE: Central nervous system (CNS) serotonin (5-HT)
exerts both excitatory and inhibitory effects on the
sympathetic nervous system (SNS) in animals. In this study,
we examine the effects of tryptophan enhancement and
depletion on plasma catecholamine levels in humans. METHODS:
The total sample consisted of 164 healthy men and women who
were tested for 2 days. Seventy-nine participants were
randomized to a tryptophan enhancement condition and 85 to a
tryptophan depletion condition. Both protocols consisted of
a "sham day," followed by an "active day." Blood samples for
assessment of plasma norepinephrine and epinephrine levels
were collected before and after tryptophan
enhancement/depletion. Data were analyzed using general
linear models. Separate analyses were conducted for each
study arm and for each measure. RESULTS: In the depletion
condition, both epinephrine (F(5,330) = 2.69, p = .021) and
norepinephrine (F(5,335) = 2.79, p = .018) showed small
increases on active versus "sham" depletion days. There were
also significant day by time interactions for epinephrine
(F(3,171) = 39.32, p < .0001) and norepinephrine (F(3,195) =
31.09, p < .0001) levels in the enhancement arm. Tryptophan
infusion resulted in a marked increase in epinephrine
(Premean = 23.92 (12.23) versus Postmean = 81.57 (62.36))
and decrease in norepinephrine (Premean = 257.2 (106.11)
versus Postmean = 177.04 (87.15)), whereas levels of both
catecholamines were stable on the "sham day." CONCLUSIONS:
CNS 5-HT exerts both inhibitory and excitatory effects on
SNS activity in humans, potentially due to stimulation of
CNS 5-HT receptors that have shown to have inhibitory
(5-HT1A) and excitatory (5-HT1A and/or 5-HT2) SNS effects in
animal models.},
Doi = {10.1097/PSY.0000000000000637},
Key = {fds340487}
}
@article{fds337114,
Author = {Singh, A and Babyak, MA and Brummett, BH and Kraus, WE and Siegler, IC and Hauser, ER and Williams, RB},
Title = {Developing a synthetic psychosocial stress measure and
harmonizing CVD-risk data: a way forward to GxE meta- and
mega-analyses.},
Journal = {Bmc Research Notes},
Volume = {11},
Number = {1},
Pages = {504},
Year = {2018},
Month = {July},
url = {http://dx.doi.org/10.1186/s13104-018-3595-z},
Abstract = {OBJECTIVES: Among many challenges in cardiovascular disease
(CVD) risk prediction are interactions of genes with stress,
race, and/or sex and developing robust estimates of these
interactions. Improved power with larger sample size
contributed by the accumulation of epidemiological data
could be helpful, but integration of these datasets is
difficult due the absence of standardized phenotypic
measures. In this paper, we describe the details of our
undertaking to harmonize a dozen datasets and provide a
detailed account of a number of decisions made in the
process. RESULTS: We harmonized candidate genetic variants
and CVD-risk variables related to demography, adiposity,
hypertension, lipodystrophy, hypertriglyceridemia,
hyperglycemia, depressive symptom, and chronic psychosocial
stress from a dozen studies. Using our synthetic stress
algorithm, we constructed a synthetic chronic psychosocial
stress measure in nine out of twelve studies where a formal
self-rated stress measure was not available. The
mega-analytic partial correlation between the stress measure
and depressive symptoms while controlling for the effect of
study variable in the combined dataset was significant
(Rho = 0.27, p < 0.0001). This evidence of the
validity and the detailed account of our data harmonization
approaches demonstrated that it is possible to overcome the
inconsistencies in the collection and measurement of human
health risk variables.},
Doi = {10.1186/s13104-018-3595-z},
Key = {fds337114}
}
@article{fds336095,
Author = {Lewis, LS and Huffman, KM and Smith, IJ and Donahue, MP and Slentz, CA and Houmard, JA and Hubal, MJ and Hoffman, EP and Hauser, ER and Siegler,
IC and Kraus, WE},
Title = {Genetic Variation in Acid Ceramidase Predicts Non-completion
of an Exercise Intervention.},
Journal = {Frontiers in Physiology},
Volume = {9},
Pages = {781},
Year = {2018},
url = {http://dx.doi.org/10.3389/fphys.2018.00781},
Abstract = {Genetic variation is associated with a number of lifestyle
behaviours; it may be associated with adherence and
individual responses to exercise training. We tested single
nucleotide polymorphisms (SNPs) in the acid ceramidase gene
(ASAH1) for association with subject adherence and
physiologic benefit with exercise training in two
well-characterised randomised, controlled 8-month exercise
interventions: STRRIDE I (n = 239) and STRRIDE II (n = 246).
Three ASAH1 non-coding SNPs in a linkage disequilibrium
block were associated with non-completion: rs2898458(G/T),
rs7508(A/G), and rs3810(A/G) were associated with
non-completion in both additive (OR = 1.8, 1.8, 2.0; P <
0.05 all) and dominant (OR = 2.5, 2.6, 3.5; P < 0.05 all)
models; with less skeletal muscle ASAH expression (p < 0.01)
in a subset (N = 60); and poorer training response in
cardiorespiratory fitness (peak VO2 change rs3810 r2 = 0.29,
P = 0.04; rs2898458 r2 = 0.29, P = 0.08; rs7508 r2 = 0.28, p
= 0.09); and similar in direction and magnitude in both
independent exploratory and replication studies. Adherence
to exercise may be partly biologically and genetically
moderated through metabolic regulatory pathways
participating in skeletal muscle adaptation to exercise
training.},
Doi = {10.3389/fphys.2018.00781},
Key = {fds336095}
}
@article{fds339606,
Author = {Brummett, BH and Babyak, MA and Singh, A and Hauser, ER and Jiang, R and Huffman, KM and Kraus, WE and Shah, SH and Siegler, IC and Williams,
RB},
Title = {Lack of Association of a Functional Polymorphism in the
Serotonin Receptor Gene With Body Mass Index and Depressive
Symptoms in a Large Meta-Analysis of Population Based
Studies.},
Journal = {Frontiers in Genetics},
Volume = {9},
Pages = {423},
Year = {2018},
url = {http://dx.doi.org/10.3389/fgene.2018.00423},
Abstract = {The serotonin receptor 5-HTR2C is thought to be involved in
the function of multiple brain structures. Consequently, the
HTR2C gene has been studied extensively with respect to its
association with a variety of phenotypes. One coding variant
in the HTR2C gene, Cys23Ser (rs6318), has been associated
with depressive symptoms. and adiposity; however, these
findings have been inconsistent. The reasons for this mixed
picture may be due to low statistical power or due to other
factors such as failure to account for possible interacting
environmental factors, such as psychosocial stress. Further,
the literature around this polymorphism is marked by limited
inclusion of persons of African ancestry. The present study
sought to overcome these limitations and definitively
determine the relationship of this polymorphism with
depressive and obesity phenotypes in a large sample
meta-analysis. Thus, we harmonized individual level data
from 10 studies including the Women's Health Initiative,
CARDIA, ARIC, Framingham Offspring, and the Jackson Heart
Study, resulting in a sample of 27,161 individuals (10,457
Black women, 2,819 Black men, 7,419 White women, and 6,466
White men). We conducted a random effects meta-analysis
using individual level data to examine whether the Cys23Ser
variant-either directly, or conditionally depending on the
level of psychosocial stress-was associated with depressive
symptoms and body mass index (BMI). We found that
psychosocial stress was associated with both depression and
BMI, but that Cys23Ser was not directly associated with, nor
did it modify the associations of psychosocial stress with
depression or BMI. Thus, in the largest study of this
polymorphism, we have determined that rs6318 is not
associated with depression, or BMI.},
Doi = {10.3389/fgene.2018.00423},
Key = {fds339606}
}
@article{fds333701,
Author = {Jiang, R and Babyak, MA and Brummett, BH and Hauser, ER and Singh, A and Siegler, IC and Williams, RB},
Title = {The effect of Brain- Derived Neurotrophic Factor (BDNF)
Val66Met Variants on the Path from Psychosocial Stress to
Depression, Body Mass Index and Pre-Clinical
Atherosclerosis},
Journal = {Genetic Epidemiology},
Volume = {41},
Number = {7},
Pages = {665-666},
Publisher = {WILEY},
Year = {2017},
Month = {November},
Key = {fds333701}
}
@article{fds319710,
Author = {Ogle, CM and Siegler, IC and Beckham, JC and Rubin,
DC},
Title = {Neuroticism Increases PTSD Symptom Severity by Amplifying
the Emotionality, Rehearsal, and Centrality of Trauma
Memories.},
Journal = {Journal of Personality},
Volume = {85},
Number = {5},
Pages = {702-715},
Year = {2017},
Month = {October},
url = {http://dx.doi.org/10.1111/jopy.12278},
Abstract = {OBJECTIVE: Although it is well established that neuroticism
increases the risk of posttraumatic stress disorder (PTSD),
little is known about the mechanisms that promote PTSD in
individuals with elevated levels of neuroticism. Across two
studies, we examined the cognitive-affective processes
through which neuroticism leads to greater PTSD symptom
severity. METHOD: Community-dwelling adults with trauma
histories varying widely in severity (Study 1) and
clinically diagnosed individuals exposed to DSM-IV-TR A1
criterion traumas (Study 2) completed measures of
neuroticism, negative affectivity, trauma memory
characteristics, and PTSD symptom severity. RESULTS:
Longitudinal data in Study 1 showed that individuals with
higher scores on two measures of neuroticism assessed
approximately three decades apart in young adulthood and
midlife reported trauma memories accompanied by more intense
physiological reactions, more frequent involuntary
rehearsal, and greater perceived centrality to identity in
older adulthood. These properties of trauma memories were in
turn associated with more severe PTSD symptoms. Study 2
replicated these findings using cross-sectional data from
individuals with severe trauma histories and three
additional measures of neuroticism. CONCLUSIONS: Results
suggest that neuroticism leads to PTSD symptoms by
magnifying the emotionality, availability, and centrality of
trauma memories as proposed in mnemonic models of
PTSD.},
Doi = {10.1111/jopy.12278},
Key = {fds319710}
}
@article{fds326504,
Author = {Jiang, R and Babyak, MA and Brummett, BH and Hauser, ER and Shah, SH and Becker, RC and Siegler, IC and Singh, A and Haynes, C and Chryst-Ladd,
M and Craig, DM and Williams, RB},
Title = {Brain-derived neurotrophic factor rs6265 (Val66Met)
polymorphism is associated with disease severity and
incidence of cardiovascular events in a patient
cohort.},
Journal = {American Heart Journal},
Volume = {190},
Pages = {40-45},
Year = {2017},
Month = {August},
url = {http://dx.doi.org/10.1016/j.ahj.2017.05.002},
Abstract = {BACKGROUND: The rs6265 (Val66Met) single-nucleotide
polymorphism in the BDNF gene has been related to a number
of endophenotypes that have in turn been shown to confer
risk for atherosclerotic cardiovascular disease (CVD). To
date, however, very few studies have examined the
association of the Val66Met single-nucleotide polymorphism
with CVD clinical outcomes. METHODS: In a cohort of 5,510
Caucasian patients enrolled in the CATHeterization GENetics
(CATHGEN) study at Duke University Hospital between 2001 and
2011, we determined the severity of coronary artery disease
(CAD) and CVD event incidence through up to 11.8years of
follow-up. We examined the association of Val66Met genotype
with time-to-death or myocardial infarction, adjusting for
age, sex, CAD risk variables, and CAD severity measures.
RESULTS: The Val/Val genotype was associated with a higher
risk than Met carriers for clinical CVD events (P=.034,
hazard ratio 1.12, 95% CI 1.01-1.24). In addition, compared
with Met carriers, individuals with the Val/Val genotype had
a greater odds of having more diseased vessels (odds ratio
1.17, 95% CI 1.06-1.30, P=.002), and lower left ventricular
ejection fraction (β=-0.72, 95% CI, -1.42 to -0.02,
P=.044). CONCLUSIONS: The Val/Val genotype was associated
with greater severity of CAD and incidence of CVD-related
clinical events in a patient sample. If these findings are
confirmed in further research, intervention studies in
clinical groups with the Val/Val genotype could be
undertaken to prevent disease and improve
prognosis.},
Doi = {10.1016/j.ahj.2017.05.002},
Key = {fds326504}
}
@article{fds324506,
Author = {Jiang, R and Babyak, MA and Brummett, BH and Siegler, IC and Kuhn, CM and Williams, RB},
Title = {Brain-derived neurotrophic factor (BDNF) Val66Met
polymorphism interacts with gender to influence cortisol
responses to mental stress.},
Journal = {Psychoneuroendocrinology},
Volume = {79},
Pages = {13-19},
Year = {2017},
Month = {May},
url = {http://dx.doi.org/10.1016/j.psyneuen.2017.02.005},
Abstract = {Brain-derived neurotrophic factor (BDNF) Val66Met
polymorphism has been associated with cortisol responses to
stress with gender differences reported, although the
findings are not entirely consistent. To evaluate the role
of Val66Met genotype and gender on cortisol responses to
stress, we conducted a 45-min mental stress protocol
including four tasks and four rest periods. Blood cortisol
was collected for assay immediately before and after each
task and rest period. A significant two-way interaction of
Val66Met genotype×gender (P=0.022) was observed on the
total area under the curve (AUC), a total cortisol response
over time, such that the Val/Val genotype was associated
with a larger cortisol response to stress as compared to the
Met group in women but not in men. Further contrast analyses
between the Val/Val and Met group for each stress task
showed a similar increased cortisol pattern among women
Val/Val genotype but not among men. The present findings
indicate the gender differences in the effect of Val66Met
genotype on the cortisol responses to stress protocol, and
extend the evidence for the importance of gender and the
role of Val66Met in the modulation of stress reactivity and
subsequent depression prevalence. Further studies and the
underlying mechanism need to be investigated, which may
provide an insight for prevention, intervention, and
treatment strategies that target those at high
risk.},
Doi = {10.1016/j.psyneuen.2017.02.005},
Key = {fds324506}
}
@article{fds323547,
Author = {Williams, RB and Bishop, GD and Haberstick, BC and Smolen, A and Brummett, BH and Siegler, IC and Babyak, MA and Zhang, X and Tai, ES and Lee, JJ-M and Tan, M and Teo, YY and Cai, S and Chan, E and Halpern, CT and Whitsel, EA and Bauldry, S and Harris, KM},
Title = {Population differences in associations of serotonin
transporter promoter polymorphism (5HTTLPR) di- and
triallelic genotypes with blood pressure and hypertension
prevalence.},
Journal = {American Heart Journal},
Volume = {185},
Pages = {110-122},
Year = {2017},
Month = {March},
url = {http://dx.doi.org/10.1016/j.ahj.2016.12.013},
Abstract = {UNLABELLED: Based on prior research finding the 5HTTLPR L
allele associated with increased cardiovascular reactivity
to laboratory stressors and increased risk of myocardial
infarction, we hypothesized that the 5HTTLPR L allele will
be associated with increased blood pressure (BP) and
increased hypertension prevalence in 2 large nationally
representative samples in the United States and Singapore.
METHODS: Logistic regression and linear models tested
associations between triallelic (L'S', based on rs25531)
5HTTLPR genotypes and hypertension severity and mean
systolic and diastolic blood pressure (SBP and DBP)
collected during the Wave IV survey of the National
Longitudinal Study of Adolescent to Adult Health (Add
Health, N=11,815) in 2008-09 and during 2004-07 in 4196
Singaporeans. RESULTS: In US Whites, L' allele carriers had
higher SBP (0.9 mm Hg, 95% CI=0.26-1.56) and greater odds
(OR=1.23, 95% CI=1.10-1.38) of more severe hypertension than
those with S'S' genotypes. In African Americans, L' carriers
had lower mean SBP (-1.27mm Hg, 95% CI=-2.53 to -0.01) and
lower odds (OR = 0.78, 95% CI=0.65-0.94) of more severe
hypertension than those with the S'S' genotype. In African
Americans, those with L'L' genotypes had lower DBP (-1.13mm
Hg, 95% CI=-2.09 to -0.16) than S' carriers. In Native
Americans, L' carriers had lower SBP (-6.05mm Hg, 95%
CI=-9.59 to -2.51) and lower odds of hypertension (OR =
0.34, 95% CI=0.13-0.89) than those with the S'S' genotype.
In Asian/Pacific Islanders those carrying the L' allele had
lower DBP (-1.77mm Hg, 95% CI=-3.16 to -0.38) and lower odds
of hypertension (OR = 0.68, 95% CI=0.48-0.96) than those
with S'S'. In the Singapore sample S' carriers had higher
SBP (3.02mm Hg, 95% CI=0.54-5.51) and DBP (1.90mm Hg, 95%
CI=0.49-3.31) than those with the L'L' genotype.
CONCLUSIONS: These findings suggest that Whites carrying the
L' allele, African Americans and Native Americans with the
S'S' genotype, and Asians carrying the S' allele will be
found to be at higher risk of developing cardiovascular
disease and may benefit from preventive measures.},
Doi = {10.1016/j.ahj.2016.12.013},
Key = {fds323547}
}
@article{fds323727,
Author = {Ogle, CM and Rubin, DC and Siegler, IC},
Title = {Commentary-Pre- and Posttrauma Predictors of Posttraumatic
Stress Disorder Symptom Severity: Reply to van der Velden
and van der Knaap (2017).},
Journal = {Clinical Psychological Science : a Journal of the
Association for Psychological Science},
Volume = {5},
Number = {1},
Pages = {146-149},
Year = {2017},
Month = {January},
url = {http://dx.doi.org/10.1177/2167702616661057},
Doi = {10.1177/2167702616661057},
Key = {fds323727}
}
@article{fds323728,
Author = {Baek, Y and Martin, P and Siegler, IC and Davey, A and Poon,
LW},
Title = {Personality Traits and Successful Aging: Findings From the
Georgia Centenarian Study.},
Journal = {Int J Aging Hum Dev},
Volume = {83},
Number = {3},
Pages = {207-227},
Year = {2016},
Month = {September},
url = {http://dx.doi.org/10.1177/0091415016652404},
Abstract = {The current study attempted to describe how personality
traits of older adults are associated with components of
successful aging (cognition, volunteering, activities of
daily living, and subjective health). Three-hundred and six
octogenarians and centenarians who participated in the third
phase of the Georgia Centenarian Study provided data for
this study. Factor analysis was conducted to test the
existence of two higher-order factors of the Big Five
personality traits, and a two-factor model (alpha and beta)
fit the data well. Also, blocked multiple regression
analysis was conducted to examine the association between
personality traits and four components of successful aging.
Results indicated that low scores on neuroticism and high
scores on extraversion, openness to experience,
agreeableness, and conscientiousness are significantly
related to the components of successful aging. After
controlling for demographic variables (age, gender,
residential type, and race/ethnicity), alpha (i.e.,
emotional stability, agreeableness, and conscientiousness)
was associated with higher levels of cognition, higher
likelihood of engaging in volunteer work, higher levels of
activities of daily living, and higher levels of subjective
health. Beta (i.e., extraversion and openness to experience)
was also positively associated with cognition and engaging
in volunteer work.},
Doi = {10.1177/0091415016652404},
Key = {fds323728}
}
@article{fds315580,
Author = {Ogle, CM and Rubin, DC and Siegler, IC},
Title = {Maladaptive trauma appraisals mediate the relation between
attachment anxiety and PTSD symptom severity.},
Journal = {Psychol Trauma},
Volume = {8},
Number = {3},
Pages = {301-309},
Year = {2016},
Month = {May},
ISSN = {1942-9681},
url = {http://hdl.handle.net/10161/12029 Duke open
access},
Abstract = {OBJECTIVE: In a large sample of community-dwelling older
adults with histories of exposure to a broad range of
traumatic events, we examined the extent to which appraisals
of traumatic events mediate the relations between insecure
attachment styles and posttraumatic stress disorder (PTSD)
symptom severity. METHOD: Participants completed an
assessment of adult attachment, in addition to measures of
PTSD symptom severity, event centrality, event severity, and
ratings of the A1 PTSD diagnostic criterion for the
potentially traumatic life event that bothered them most at
the time of the study. RESULTS: Consistent with theoretical
proposals and empirical studies indicating that individual
differences in adult attachment systematically influence how
individuals evaluate distressing events, individuals with
higher attachment anxiety perceived their traumatic life
events to be more central to their identity and more severe.
Greater event centrality and event severity were each in
turn related to higher PTSD symptom severity. In contrast,
the relation between attachment avoidance and PTSD symptoms
was not mediated by appraisals of event centrality or event
severity. Furthermore, neither attachment anxiety nor
attachment avoidance was related to participants' ratings of
the A1 PTSD diagnostic criterion. CONCLUSION: Our findings
suggest that attachment anxiety contributes to greater PTSD
symptom severity through heightened perceptions of traumatic
events as central to identity and severe. (PsycINFO Database
Record},
Doi = {10.1037/tra0000112},
Key = {fds315580}
}
@article{fds315581,
Author = {Ogle, CM and Rubin, DC and Siegler, IC},
Title = {Accounting for Posttraumatic Stress Disorder Symptom
Severity With Pre- and Posttrauma Measures: A Longitudinal
Study of Older Adults.},
Journal = {Clinical Psychological Science : a Journal of the
Association for Psychological Science},
Volume = {4},
Number = {2},
Pages = {272-286},
Year = {2016},
Month = {March},
ISSN = {2167-7026},
url = {http://hdl.handle.net/10161/12025 Duke open
access},
Abstract = {Using data from a longitudinal study of community-dwelling
older adults, we analyzed the most extensive set of known
correlates of PTSD symptoms obtained from a single sample to
examine the measures' independent and combined utility in
accounting for PTSD symptom severity. Fifteen measures
identified as PTSD risk factors in published meta-analyses
and 12 theoretically and empirically supported individual
difference and health-related measures were included.
Individual difference measures assessed after the trauma,
including insecure attachment and factors related to the
current trauma memory, such as self-rated severity, event
centrality, frequency of involuntary recall, and physical
reactions to the memory, accounted for symptom severity
better than measures of pre-trauma factors. In an analysis
restricted to prospective measures assessed before the
trauma, the total variance explained decreased from 56% to
16%. Results support a model of PTSD in which
characteristics of the current trauma memory promote the
development and maintenance of PTSD symptoms.},
Doi = {10.1177/2167702615583227},
Key = {fds315581}
}
@article{fds315961,
Author = {Haberstick, BC and Boardman, JD and Wagner, B and Smolen, A and Hewitt,
JK and Killeya-Jones, LA and Tabor, J and Halpern, CT and Brummett, BH and Williams, RB and Siegler, IC and Hopfer, CJ and Mullan Harris,
K},
Title = {Depression, Stressful Life Events, and the Impact of
Variation in the Serotonin Transporter: Findings from the
National Longitudinal Study of Adolescent to Adult Health
(Add Health).},
Journal = {Plos One},
Volume = {11},
Number = {3},
Pages = {e0148373},
Year = {2016},
url = {http://dx.doi.org/10.1371/journal.pone.0148373},
Abstract = {BACKGROUND: The low transcriptionally efficient short-allele
of the 5HTTLPR serotonin transporter polymorphism has been
implicated to moderate the relationship between the
experience of stressful life events (SLEs) and depression.
Despite numerous attempts at replicating this observation,
results remain inconclusive. METHODS: We examined this
relationship in young-adult Non-Hispanic white males and
females between the ages of 22 and 26 (n = 4724)
participating in the National Longitudinal Study of
Adolescent to Adult Health (Add Health) with follow-up
information every six years since 1995. RESULTS: Linear and
logistic regression models, corrected for multiple testing,
indicated that carriers of one or more of the S-alleles were
more sensitive to stress than those with two L-alleles and
at a higher risk for depression. This relationship behaved
in a dose-response manner such that the risk for depression
was greatest among those who reported experiencing higher
numbers of SLEs. In post-hoc analyses we were not able to
replicate an interaction effect for suicide ideation but did
find suggestive evidence that the effects of SLEs and
5HTTLPR on suicide ideation differed for males and females.
There were no effects of childhood maltreatment. DISCUSSION:
Our results provide partial support for the original
hypothesis that 5-HTTLPR genotype interacts with the
experience of stressful life events in the etiology of
depression during young adulthood. However, even with this
large sample, and a carefully constructed a priori analysis
plan, the results were still not definitive. For the
purposes of replication, characterizing the 5HTTLPR in other
large data sets with extensive environmental and depression
measures is needed.},
Doi = {10.1371/journal.pone.0148373},
Key = {fds315961}
}
@article{fds276042,
Author = {Ribeiro, JD and Yen, S and Joiner, T and Siegler,
IC},
Title = {Capability for suicide interacts with states of heightened
arousal to predict death by suicide beyond the effects of
depression and hopelessness.},
Journal = {J Affect Disord},
Volume = {188},
Pages = {53-59},
Year = {2015},
Month = {December},
ISSN = {0165-0327},
url = {http://dx.doi.org/10.1016/j.jad.2015.07.037},
Abstract = {BACKGROUND: States of heightened arousal (e.g., agitation,
sleep disturbance) have been repeatedly linked to suicidal
thoughts and behaviors, including attempts and death.
Studies have further indicated that these states may be
particularly pernicious among individuals who evidence high
suicidal capability. The objective of this study was to
examine the interactive effects of heightened arousal and
the capability for suicide in the prospective prediction of
death by suicide. We examine this relation beyond the
effects of robust predictors of suicide, namely depression
and hopelessness. METHODS: Participants were drawn from a
larger study of undergraduates who completed baseline
assessments during their freshman year and were then
followed to time of death. The sample in this study only
included individuals who had died by suicide (n=96) or other
causes (n=542). Proxy measures to assess predictor variables
were constructed using items from the MMPI, which was
administered at baseline. An independent sample of clinical
outpatients (n=was used to evaluate the construct validity
of the proxy measures). RESULTS: Results were in line with
expectation: heightened arousal interacted with capability
for suicide to prospectively predict death by suicide, such
that, as severity of heightened arousal symptoms increased,
the likelihood of death by suicide increased among
individuals high but not low on capability for suicide.
LIMITATIONS: Limitations include the use of proxy measures,
the extended length of follow-up, and the homogeneity of the
sample (i.e., primarily White males). CONCLUSION: These
findings add to an emerging literature that supports the
moderating influence of capability for suicide on the
relationship between states of heightened arousal on the
likelihood of death by suicide.},
Doi = {10.1016/j.jad.2015.07.037},
Key = {fds276042}
}
@article{fds276044,
Author = {Singh, A and Babyak, MA and Brummett, BH and Jiang, R and Watkins, LL and Barefoot, JC and Kraus, WE and Shah, SH and Siegler, IC and Hauser, ER and Williams, RB},
Title = {Computing a Synthetic Chronic Psychosocial Stress
Measurement in Multiple Datasets and its Application in the
Replication of G × E Interactions of the EBF1
Gene.},
Journal = {Genetic Epidemiology},
Volume = {39},
Number = {6},
Pages = {489-497},
Year = {2015},
Month = {September},
ISSN = {0741-0395},
url = {http://dx.doi.org/10.1002/gepi.21910},
Abstract = {Chronic psychosocial stress adversely affects health and is
associated with the development of disease [Williams, 2008].
Systematic epidemiological and genetic studies are needed to
uncover genetic variants that interact with stress to modify
metabolic responses across the life cycle that are the
proximal contributors to the development of cardiovascular
disease and precipitation of acute clinical events. Among
the central challenges in the field are to perform and
replicate gene-by-environment (G × E) studies. The
challenge of measurement of individual experience of
psychosocial stress is magnified in this context. Although
many research datasets exist that contain genotyping and
disease-related data, measures of psychosocial stress are
often either absent or vary substantially across studies. In
this paper, we provide an algorithm to create a synthetic
measure of chronic psychosocial stress across multiple
datasets, applying a consistent criterion that uses proxy
indicators of stress components. We validated the computed
scores of chronic psychosocial stress by observing
moderately strong and significant correlations with the
self-rated chronic psychosocial stress in the Multi-Ethnic
Study of Atherosclerosis Cohort (Rho = 0.23, P < 0.0001) and
with the measures of depressive symptoms in five datasets
(Rho = 0.15-0.42, Ps = 0.005 to <0.0001) and by comparing
the distributions of the self-rated and computed measures.
Finally, we demonstrate the utility of this computed chronic
psychosocial stress variable by providing three additional
replications of our previous finding of gene-by-stress
interaction with central obesity traits [Singh et al.,
2015].},
Doi = {10.1002/gepi.21910},
Key = {fds276044}
}
@article{fds276048,
Author = {Ogle, CM and Rubin, DC and Siegler, IC},
Title = {The relation between insecure attachment and posttraumatic
stress: Early life versus adulthood traumas.},
Journal = {Psychol Trauma},
Volume = {7},
Number = {4},
Pages = {324-332},
Year = {2015},
Month = {July},
ISSN = {1942-9681},
url = {http://dx.doi.org/10.1037/tra0000015},
Abstract = {The present study examined the relations between insecure
attachment and posttraumatic stress disorder (PTSD) symptoms
among community-dwelling older adults with exposure to a
broad range of traumatic events. Attachment anxiety and
attachment avoidance predicted more severe symptoms of PTSD
and explained unique variance in symptom severity when
compared to other individual difference measures associated
with an elevated risk of PTSD, including NEO neuroticism and
event centrality. A significant interaction between the
developmental timing of the trauma and attachment anxiety
revealed that the relation between PTSD symptoms and
attachment anxiety was stronger for individuals with current
PTSD symptoms associated with early life traumas compared to
individuals with PTSD symptoms linked to adulthood traumas.
Analyses examining factors that account for the relation
between insecure attachment and PTSD symptoms indicated that
individuals with greater attachment anxiety reported
stronger physical reactions to memories of their trauma and
more frequent voluntary and involuntary rehearsal of their
trauma memories. These phenomenological properties of trauma
memories were in turn associated with greater PTSD symptom
severity. Among older adults with early life traumas, only
the frequency of involuntary recall partially accounted for
the relation between attachment anxiety and PTSD symptoms.
Our differential findings concerning early life versus
adulthood trauma suggest that factors underlying the
relation between attachment anxiety and PTSD symptoms vary
according to the developmental timing of the traumatic
exposure. Overall our results are consistent with attachment
theory and with theoretical models of PTSD according to
which PTSD symptoms are promoted by phenomenological
properties of trauma memories.},
Doi = {10.1037/tra0000015},
Key = {fds276048}
}
@article{fds276050,
Author = {Singh, A and Babyak, MA and Nolan, DK and Brummett, BH and Jiang, R and Siegler, IC and Kraus, WE and Shah, SH and Williams, RB and Hauser,
ER},
Title = {Gene by stress genome-wide interaction analysis and path
analysis identify EBF1 as a cardiovascular and metabolic
risk gene.},
Journal = {European Journal of Human Genetics : Ejhg},
Volume = {23},
Number = {6},
Pages = {854-862},
Year = {2015},
Month = {June},
ISSN = {1018-4813},
url = {http://dx.doi.org/10.1038/ejhg.2014.189},
Abstract = {We performed gene-environment interaction genome-wide
association analysis (G × E GWAS) to identify SNPs whose
effects on metabolic traits are modified by chronic
psychosocial stress in the Multi-Ethnic Study of
Atherosclerosis (MESA). In Whites, the G × E GWAS for hip
circumference identified five SNPs within the Early B-cell
Factor 1 (EBF1) gene, all of which were in strong linkage
disequilibrium. The gene-by-stress interaction (SNP ×
STRESS) term P-values were genome-wide significant (Ps =
7.14E-09 to 2.33E-08, uncorrected; Ps = 1.99E-07 to
5.18E-07, corrected for genomic control). The SNP-only
(without interaction) model P-values (Ps = 0.011-0.022) were
not significant at the conventional genome-wide significance
level. Further analysis of related phenotypes identified
gene-by-stress interaction effects for waist circumference,
body mass index (BMI), fasting glucose, type II diabetes
status, and common carotid intimal-medial thickness (CCIMT),
supporting a proposed model of gene-by-stress interaction
that connects cardiovascular disease (CVD) risk factor
endophenotypes such as central obesity and increased blood
glucose or diabetes to CVD itself. Structural equation path
analysis suggested that the path from chronic psychosocial
stress to CCIMT via hip circumference and fasting glucose
was larger (estimate = 0.26, P = 0.033, 95% CI = 0.02-0.49)
in the EBF1 rs4704963 CT/CC genotypes group than the same
path in the TT group (estimate = 0.004, P = 0.34, 95% CI =
-0.004-0.012). We replicated the association of the EBF1
SNPs and hip circumference in the Framingham Offspring
Cohort (gene-by-stress term P-values = 0.007-0.012) as well
as identified similar path relationships. This observed and
replicated interaction between psychosocial stress and
variation in the EBF1 gene may provide a biological
hypothesis for the complex relationship between psychosocial
stress, central obesity, diabetes, and cardiovascular
disease.},
Doi = {10.1038/ejhg.2014.189},
Key = {fds276050}
}
@article{fds276046,
Author = {Haberstick, BC and Smolen, A and Williams, RB and Bishop, GD and Foshee,
VA and Thornberry, TP and Conger, R and Siegler, IC and Zhang, X and Boardman, JD and Frajzyngier, Z and Stallings, MC and Brent
Donnellan, M and Halpern, CT and Harris, KM},
Title = {Population frequencies of the Triallelic 5HTTLPR in six
Ethnicially diverse samples from North America, Southeast
Asia, and Africa.},
Journal = {Behav Genet},
Volume = {45},
Number = {2},
Pages = {255-261},
Year = {2015},
Month = {March},
ISSN = {0001-8244},
url = {http://dx.doi.org/10.1007/s10519-014-9703-5},
Abstract = {Genetic differences between populations are potentially an
important contributor to health disparities around the
globe. As differences in gene frequencies influence study
design, it is important to have a thorough understanding of
the natural variation of the genetic variant(s) of interest.
Along these lines, we characterized the variation of the
5HTTLPR and rs25531 polymorphisms in six samples from North
America, Southeast Asia, and Africa (Cameroon) that differ
in their racial and ethnic composition. Allele and genotype
frequencies were determined for 24,066 participants. Results
indicated higher frequencies of the rs25531 G-allele among
Black and African populations as compared with White,
Hispanic and Asian populations. Further, we observed a
greater number of 'extra-long' ('XL') 5HTTLPR alleles than
have previously been reported. Extra-long alleles occurred
almost entirely among Asian, Black and Non-White Hispanic
populations as compared with White and Native American
populations where they were completely absent. Lastly, when
considered jointly, we observed between sample differences
in the genotype frequencies within racial and ethnic
populations. Taken together, these data underscore the
importance of characterizing the L-G allele to avoid
misclassification of participants by genotype and for
further studies of the impact XL alleles may have on the
transcriptional efficiency of SLC6A4.},
Doi = {10.1007/s10519-014-9703-5},
Key = {fds276046}
}
@article{fds276045,
Author = {Cho, J and Martin, P and Poon, LW and Georgia Centenarian
Study},
Title = {Successful aging and subjective well-being among oldest-old
adults.},
Journal = {The Gerontologist},
Volume = {55},
Number = {1},
Pages = {132-143},
Year = {2015},
Month = {February},
ISSN = {0016-9013},
url = {http://dx.doi.org/10.1093/geront/gnu074},
Abstract = {PURPOSE OF THE STUDY: This research integrates successful
aging and developmental adaptation models to empirically
define the direct and indirect effects of 2 distal (i.e.,
education and past life experiences) and 5 proximal
influences (i.e., physical functioning, cognitive
functioning, physical health impairment, social resources,
and perceived economic status) on subjective well-being. The
proximal influences involved predictors outlined in most
extant models of successful aging (e.g., Rowe & Kahn, 1998
[Rowe, J. W., & Kahn, R. L. (1998). Successful aging. New
York: Pantheon Books.]). Our model extends such models by
including distal impact as well as interactions between
distal and proximal impacts. DESIGN AND METHODS: Data were
obtained from 234 centenarians and 72 octogenarians in the
Georgia Centenarian Study. Structural equation modeling was
conducted with Mplus 6.1. RESULTS: Results showed
significant direct effects of physical health impairment and
social resources on positive aspects of subjective
well-being among oldest-old adults. We also found
significant indirect effects of cognitive functioning and
education on positive affect among oldest-old adults. Social
resources mediated the relationship between cognitive
functioning and positive affect; and cognitive functioning
and social resources mediated the relationship between
education and positive affect. In addition, physical health
impairment mediated the relationship between cognitive
functioning and positive affect; and cognitive functioning
and physical health impairment mediated the relationship
between education and positive affect. IMPLICATIONS:
Integrating 2 different models (i.e., successful aging and
developmental adaptation) provided a comprehensive view of
adaptation from a developmental perspective.},
Doi = {10.1093/geront/gnu074},
Key = {fds276045}
}
@article{fds276053,
Author = {Boyle, SH and Georgiades, A and Brummett, BH and Barefoot, JC and Siegler, IC and Matson, WR and Kuhn, CM and Grichnik, K and Stafford-Smith, M and Williams, RB and Kaddurah-Daouk, R and Surwit,
RS},
Title = {Associations between central nervous system serotonin,
fasting glucose, and hostility in African American
females.},
Journal = {Annals of Behavioral Medicine : a Publication of the Society
of Behavioral Medicine},
Volume = {49},
Number = {1},
Pages = {49-57},
Year = {2015},
Month = {February},
ISSN = {0883-6612},
url = {http://dx.doi.org/10.1007/s12160-014-9626-7},
Abstract = {BACKGROUND: Previous research has shown an association
between hostility and fasting glucose in African American
women. Central nervous system serotonin activity is
implicated both in metabolic processes and in hostility
related traits. PURPOSE: The purpose of this study is to
determine whether central nervous system serotonin
influences the association between hostility and fasting
glucose in African American women. METHODS: The study
consisted of 119 healthy volunteers (36 African American
women, 27 White women, 21 White males, and 35 African
American males, mean age 34 ± 8.5 years). Serotonin
related compounds were measured in cerebrospinal fluid.
Hostility was measured by the Cook-Medley Hostility Scale.
RESULTS: Hostility was associated with fasting glucose and
central nervous system serotonin related compounds in
African American women only. Controlling for the serotonin
related compounds significantly reduced the association of
hostility to glucose. CONCLUSIONS: The positive correlation
between hostility and fasting glucose in African American
women can partly be explained by central nervous system
serotonin function.},
Doi = {10.1007/s12160-014-9626-7},
Key = {fds276053}
}
@article{fds276041,
Author = {Rahman-Filipiak, A and Woodard, JL and Miller, LS and Martin, P and Davey, A and Poon, LW and Georgia Centenarian Study},
Title = {Octogenarian and centenarian performance on the Fuld Object
Memory Evaluation.},
Journal = {Neuropsychol Dev Cogn B Aging Neuropsychol
Cogn},
Volume = {22},
Number = {4},
Pages = {438-451},
Year = {2015},
ISSN = {1382-5585},
url = {http://dx.doi.org/10.1080/13825585.2014.968085},
Abstract = {The Fuld Object Memory Evaluation (FOME) has considerable
utility for cognitive assessment in older adults, but there
are few normative data, particularly for the oldest old. In
this study, 80 octogenarians and 244 centenarians from the
Georgia Centenarian Study completed the FOME. Total and
trial-to-trial performance on the storage, retrieval,
repeated retrieval, and ineffective reminder indices were
assessed. Additional data stratified by age group,
education, and cognitive impairment are provided in the
Supplemental data. Octogenarians performed significantly
better than centenarians on all FOME measures. Neither age
group benefitted from additional learning trials beyond
Trial 3 for storage and Trial 2 for retention and retrieval.
Ineffective reminders showed no change across learning
trials for octogenarians, while centenarians improved only
between Trials 1 and 2. This minimal improvement past Trial
2 indicates that older adults might benefit from a truncated
version of the test that does not include trials three
through five, with the added benefit of reducing testing
burden in this population.},
Doi = {10.1080/13825585.2014.968085},
Key = {fds276041}
}
@article{fds276043,
Author = {Davey, A and Siegler, IC and Martin, P and Costa, PT and Poon, LW and Georgia Centenarian Study},
Title = {Personality Structure Among Centenarians: The Georgia
Centenarian Study.},
Journal = {Experimental Aging Research},
Volume = {41},
Number = {4},
Pages = {361-385},
Year = {2015},
ISSN = {0361-073X},
url = {http://dx.doi.org/10.1080/0361073X.2015.1053752},
Abstract = {UNLABELLED: BACKGROUND/STUDY CONTEXT: We demonstrate that
observer-rated factor structure of personality in
centenarians is congruent with the normative structure.
Prevalence of cognitive impairment, which has previously
been linked to changes in personality in younger samples, is
high in this age group, requiring observer ratings to obtain
valid data in a population-based context. Likewise, the
broad range of cognitive functioning necessitates synthesis
of results across multiple measures of cognitive
performance. METHODS AND RESULTS: Data from 161 participants
in the Georgia Centenarian Study (GCS; MAge = 100.3 years,
84% women, 20% African American, 40% community-dwelling, 30%
low cognitive functioning) support strong overall
correspondence with reference structure (full sample: .94;
higher cognitive functioning: .94; lower cognitive
functioning: .90). Centenarians with lower cognitive
functioning are higher on neuroticism and lower on openness
to experience, agreeableness, and conscientiousness.
Facet-level differences (higher N1-N6: anxiety, hostility,
depression, self-consciousness, impulsiveness, vulnerability
to stress; lower E1: warmth; lower O4-O6: actions, ideas,
values; lower A1, A3, A4: trust, altruism, compliance; C1,
C5: competence, self-discipline) are also observed.
Multivariate factor-level models indicate only neuroticism
of the five broad factors predicts membership in cognitively
impaired group; facet-level models showed that lower-order
scales from three of the five domains were significant.
Centenarians with higher self-consciousness (N4),
impulsiveness (N5), and deliberation (C6) but lower ideas
(O5), compliance (A4), and self-discipline (C5) were more
likely to be in the lower cognitive functioning category.
CONCLUSION: Results present first normative population-based
data for personality structure in centenarians and offer
intriguing possibilities for the role of personality in
cognitive impairment centered on neuroticism.},
Doi = {10.1080/0361073X.2015.1053752},
Key = {fds276043}
}
@article{fds276049,
Author = {Brummett, BH and Babyak, MA and Kuhn, CM and Siegler, IC and Williams,
RB},
Title = {A functional polymorphism in the HTR2C gene associated with
stress responses: a validation study.},
Journal = {Biol Psychol},
Volume = {103},
Pages = {317-321},
Year = {2014},
Month = {December},
ISSN = {0301-0511},
url = {http://dx.doi.org/10.1016/j.biopsycho.2014.10.006},
Abstract = {Previously we have shown that a functional nonsynonymous
single nucleotide polymorphism (SNP), rs6318 on the HTR2C
gene located on the X-chromosome, is associated with
hypothalamic-pituitary-adrenal axis response to a laboratory
stress recall task. The present paper reports a validation
of the cortisol response to stress in a second, independent
sample. The study population consisted of 60 adult
participants (73.3% males). Consistent with our prior
findings, compared to Cys23 G allele carriers, persons
homozygous for the Ser23C allele had a significantly greater
average cortisol response (p=0.007) and area under the curve
(p=0.021) over the course of an emotional stress recall
protocol. Also parallel to our prior report, the change in
cortisol from baseline to the average during the stress
protocol was roughly twice as large among Ser23C homozygotes
than among persons with Cys23 G. These findings validate our
initial observation of association between rs6318 and
cortisol response to an acute stressor, and extend the
results to include females.},
Doi = {10.1016/j.biopsycho.2014.10.006},
Key = {fds276049}
}
@article{fds276052,
Author = {Costa, PT and Weiss, A and Duberstein, PR and Friedman, B and Siegler,
IC},
Title = {Personality facets and all-cause mortality among Medicare
patients aged 66 to 102 years: a follow-on study of Weiss
and Costa (2005).},
Journal = {Psychosom Med},
Volume = {76},
Number = {5},
Pages = {370-378},
Year = {2014},
Month = {June},
ISSN = {0033-3174},
url = {http://dx.doi.org/10.1097/PSY.0000000000000070},
Abstract = {OBJECTIVE: To investigate associations between personality
facets and survival during an 8-year follow-up. METHODS: In
597 Medicare recipients (age, 66-102 years) followed up for
approximately 8 years, personality domains and facets were
assessed using the Revised NEO Personality Inventory
(NEO-PI-R). This study builds on a previous study which used
proportional hazards regression to test whether the NEO-PI-R
factor and selected facet scores were associated with
mortality risk. That study revealed that the neuroticism
facet impulsiveness, agreeableness facet
straightforwardness, and conscientiousness facet
self-discipline were related to lower risk during 4 years of
follow-up. We extended the follow-up period by 4 years,
examined all 30 facets, and used accelerated failure time
modeling as an additional analytic approach. Unlike
proportional hazards regression, accelerated failure time
modeling permits inferences about the median survival length
conferred by predictors. Each facet was tested in a model
that included health-related covariates and NEO-PI-R factor
scores for dimensions that did not include that facet.
RESULTS: Over the 8-year follow-up period, impulsiveness was
not significant, each standard deviation of
straightforwardness was associated with an 11% increase in
median survival time and, when dichotomized, higher
self-discipline was associated with a 34% increase in median
survival time. Each standard deviation of altruism,
compliance, tender-mindedness, and openness to fantasy was
associated with a 9% to 11% increase in median survival
time. CONCLUSIONS: After extending the follow-up period from
4 to 8 years, self-discipline remained a powerful predictor
of survival and facets associated with imagination,
generosity, and higher-quality interpersonal interactions
become increasingly important.},
Doi = {10.1097/PSY.0000000000000070},
Key = {fds276052}
}
@article{fds276070,
Author = {Ogle, CM and Rubin, DC and Siegler, IC},
Title = {Changes in neuroticism following trauma exposure.},
Journal = {Journal of Personality},
Volume = {82},
Number = {2},
Pages = {93-102},
Year = {2014},
Month = {April},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23550961},
Abstract = {Using longitudinal data, the present study examined change
in midlife neuroticism following trauma exposure. Our
primary analyses included 670 participants (M(age) = 60.55;
65.22% male, 99.70% Caucasian) who completed the NEO
Personality Inventory at ages 42 and 50 and reported their
lifetime exposure to traumatic events approximately 10 years
later. No differences in pre- and post-trauma neuroticism
scores were found among individuals who experienced all of
their lifetime traumas in the interval between the
personality assessments. Results were instead consistent
with normative age-related declines in neuroticism
throughout adulthood. Furthermore, longitudinal changes in
neuroticism scores did not differ between individuals with
and without histories of midlife trauma exposure.
Examination of change in neuroticism following
life-threatening traumas yielded a comparable pattern of
results. Analysis of facet-level scores largely replicated
findings from the domain scores. Overall, our findings
suggest that neuroticism does not reliably change following
exposure to traumatic events in middle adulthood.
Supplemental analyses indicated that individuals exposed to
life-threatening traumas in childhood or adolescence
reported higher midlife neuroticism than individuals who
experienced severe traumas in adulthood. Life-threatening
traumatic events encountered early in life may have a more
pronounced impact on adulthood personality than recent
traumatic events.},
Doi = {10.1111/jopy.12037},
Key = {fds276070}
}
@article{fds276065,
Author = {Martin, P and Jazwinski, SM and Davey, A and Green, RC and Macdonald, M and Margrett, JA and Siegler, IC and Arnold, J and Woodard, JL and Johnson,
MA and Kim, S and Dai, J and Li, L and Batzer, MA and Poon, LW and For The
Georgia Centenarian Study},
Title = {APOE ϵ4, rated life experiences, and affect among
centenarians.},
Journal = {Aging Ment Health},
Volume = {18},
Number = {2},
Pages = {240-247},
Year = {2014},
Month = {March},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23998924},
Abstract = {OBJECTIVES: The purpose of this study was to assess the
relationship between apolipoprotein E (APOE), life events
and engagement, and subjective well-being (as measured by
positive and negative affect) among centenarians. Based on
the life stress paradigm, we predicted that higher levels of
stress would allow APOE to influence positive and negative
affect. METHOD: 196 centenarians and near-centenarians (98
years and older) of the Georgia Centenarian Study
participated in this research. The APOE, positive and
negative affect, the number of recent (last 2 years) and
lifelong (more than 20 years prior to testing) events, as
well as a number of life engagement tasks were assessed.
RESULTS: Results suggested that centenarians carrying the
APOE ϵ4 allele rated lower in positive affect, the number
of lifelong events, and in engaged lifestyle, when compared
to centenarians without the APOE ϵ4 allele (t = 3.43, p <
.01; t = 3.19, p < .01; and t = 2.33, p < .05,
respectively). Blockwise multiple regressions indicated that
the APOE ϵ4 predicted positive but not negative affect
after controlling for demographics. Gene-environment
interactions were obtained for the APOE ϵ4 and lifelong
events, suggesting that carriers of the APOE ϵ4 allele had
higher scores of negative affect after having experienced
more events, whereas noncarriers had reduced negative affect
levels after having experienced more events. CONCLUSION:
APOE ϵ4 is directly related to positive affect and is
related to negative affect in interaction with life
events.},
Doi = {10.1080/13607863.2013.827624},
Key = {fds276065}
}
@article{fds276067,
Author = {Haberstick, BC and Lessem, JM and Hewitt, JK and Smolen, A and Hopfer,
CJ and Halpern, CT and Killeya-Jones, LA and Boardman, JD and Tabor, J and Siegler, IC and Williams, RB and Mullan Harris,
K},
Title = {MAOA genotype, childhood maltreatment, and their interaction
in the etiology of adult antisocial behaviors.},
Journal = {Biol Psychiatry},
Volume = {75},
Number = {1},
Pages = {25-30},
Year = {2014},
Month = {January},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23726513},
Abstract = {BACKGROUND: Maltreatment by an adult or caregiver during
childhood is a prevalent and important predictor of
antisocial behaviors in adulthood. A functional promoter
polymorphism in the monoamine oxidase A (MAOA) gene has been
implicated as a moderating factor in the relationship
between childhood maltreatment and antisocial behaviors.
Although there have been numerous attempts at replicating
this observation, results remain inconclusive. METHODS: We
examined this gene-environment interaction hypothesis in a
sample of 3356 white and 960 black men (aged 24-34)
participating in the National Longitudinal Study of
Adolescent Health. RESULTS: Primary analysis indicated that
childhood maltreatment was a significant risk factor for
later behaviors that violate rules and the rights of others
(p < .05), there were no main effects of MAOA genotype, and
MAOA genotype was not a significant moderator of the
relationship between maltreatment and antisocial behaviors
in our white sample. Post hoc analyses identified a similar
pattern of results among our black sample in which
maltreatment was not a significant predictor of antisocial
behavior. Post hoc analyses also revealed a main effect of
MAOA genotype on having a disposition toward violence in
both samples and for violent convictions among our black
sample. None of these post hoc findings, however, survived
correction for multiple testing (p > .05). Power analyses
indicated that these results were not due to insufficient
statistical power. CONCLUSIONS: We could not confirm the
hypothesis that MAOA genotype moderates the relationship
between childhood maltreatment and adult antisocial
behaviors.},
Doi = {10.1016/j.biopsych.2013.03.028},
Key = {fds276067}
}
@article{fds276047,
Author = {Brummett, BH and Babyak, MA and Williams, RB and Harris, KM and Jiang,
R and Kraus, WE and Singh, A and Costa, PT and Georgiades, A and Siegler,
IC},
Title = {A putatively functional polymorphism in the HTR2C gene is
associated with depressive symptoms in white females
reporting significant life stress.},
Journal = {Plos One},
Volume = {9},
Number = {12},
Pages = {e114451},
Year = {2014},
url = {http://dx.doi.org/10.1371/journal.pone.0114451},
Abstract = {Psychosocial stress is well known to be positively
associated with subsequent depressive symptoms. Cortisol
response to stress may be one of a number of biological
mechanisms that links psychological stress to depressive
symptoms, although the precise causal pathway remains
unclear. Activity of the x-linked serotonin 5-HTR2C receptor
has also been shown to be associated with depression and
with clinical response to antidepressant medications. We
recently demonstrated that variation in a single nucleotide
polymorphism on the HTR2C gene, rs6318 (Ser23Cys), is
associated with different cortisol release and short-term
changes in affect in response to a series of stress tasks in
the laboratory. Based on this observation, we decided to
examine whether rs6318 might moderate the association
between psychosocial stress and subsequent depressive
symptoms. In the present study we use cross-sectional data
from a large population-based sample of young adult White
men (N = 2,366) and White women (N = 2,712) in the
United States to test this moderation hypothesis.
Specifically, we hypothesized that the association between
self-reported stressful life events and depressive symptoms
would be stronger among homozygous Ser23 C females and
hemizygous Ser23 C males than among Cys23 G carriers. In
separate within-sex analyses a genotype-by-life stress
interaction was observed for women (p = .022) but not
for men (p = .471). Homozygous Ser23 C women who
reported high levels of life stress had depressive symptom
scores that were about 0.3 standard deviations higher than
female Cys23 G carriers with similarly high stress levels.
In contrast, no appreciable difference in depressive
symptoms was observed between genotypes at lower levels of
stress. Our findings support prior work that suggests a
functional SNP on the HTR2C gene may confer an increased
risk for depressive symptoms in White women with a history
of significant life stress.},
Doi = {10.1371/journal.pone.0114451},
Key = {fds276047}
}
@article{fds276064,
Author = {Ogle, CM and Rubin, DC and Siegler, IC},
Title = {Cumulative exposure to traumatic events in older
adults.},
Journal = {Aging Ment Health},
Volume = {18},
Number = {3},
Pages = {316-325},
Year = {2014},
url = {http://www.ncbi.nlm.nih.gov/pubmed/24011223},
Abstract = {OBJECTIVES: The present study examined the impact of
cumulative trauma exposure on current posttraumatic stress
disorder (PTSD) symptom severity in a nonclinical sample of
adults in their 60s. The predictive utility of cumulative
trauma exposure was compared to other known predictors of
PTSD, including trauma severity, personality traits, social
support, and event centrality. METHOD: Community-dwelling
adults (n = 2515) from the crest of the Baby Boom generation
completed the Traumatic Life Events Questionnaire, the PTSD
Checklist, the NEO Personality Inventory, the Centrality of
Event Scale, and rated their current social support.
RESULTS: Cumulative trauma exposure predicted greater PTSD
symptom severity in hierarchical regression analyses
consistent with a dose-response model. Neuroticism and event
centrality also emerged as robust predictors of PTSD symptom
severity. In contrast, the severity of individuals' single
most distressing life event, as measured by self-report
ratings of the A1 PTSD diagnostic criterion, did not add
explanatory variance to the model. Analyses concerning event
categories revealed that cumulative exposure to childhood
violence and adulthood physical assaults were most strongly
associated with PTSD symptom severity in older adulthood.
Moreover, cumulative self-oriented events accounted for a
larger percentage of variance in symptom severity compared
to events directed at others. CONCLUSION: Our findings
suggest that the cumulative impact of exposure to traumatic
events throughout the life course contributes significantly
to posttraumatic stress in older adulthood above and beyond
other known predictors of PTSD.},
Doi = {10.1080/13607863.2013.832730},
Key = {fds276064}
}
@article{fds276069,
Author = {Ogle, CM and Rubin, DC and Siegler, IC},
Title = {The impact of the developmental timing of trauma exposure on
PTSD symptoms and psychosocial functioning among older
adults.},
Journal = {Dev Psychol},
Volume = {49},
Number = {11},
Pages = {2191-2200},
Year = {2013},
Month = {November},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23458662},
Abstract = {The present study examined the impact of the developmental
timing of trauma exposure on posttraumatic stress disorder
(PTSD) symptoms and psychosocial functioning in a large
sample of community-dwelling older adults (N = 1,995).
Specifically, we investigated whether the negative
consequences of exposure to traumatic events were greater
for traumas experienced during childhood, adolescence, young
adulthood, midlife, or older adulthood. Each of these
developmental periods is characterized by age-related
changes in cognitive and social processes that may influence
psychological adjustment following trauma exposure. Results
revealed that older adults who experienced their currently
most distressing traumatic event during childhood exhibited
more severe symptoms of PTSD and lower subjective happiness
compared with older adults who experienced their most
distressing trauma after the transition to adulthood.
Similar findings emerged for measures of social support and
coping ability. The differential effects of childhood
compared with later life traumas were not fully explained by
differences in cumulative trauma exposure or by differences
in the objective and subjective characteristics of the
events. Our findings demonstrate the enduring nature of
traumatic events encountered early in the life course and
underscore the importance of examining the developmental
context of trauma exposure in investigations of the
long-term consequences of traumatic experiences.},
Doi = {10.1037/a0031985},
Key = {fds276069}
}
@article{fds276059,
Author = {Ogle, CM and Rubin, DC and Berntsen, D and Siegler,
IC},
Title = {The Frequency and Impact of Exposure to Potentially
Traumatic Events Over the Life Course.},
Journal = {Clinical Psychological Science : a Journal of the
Association for Psychological Science},
Volume = {1},
Number = {4},
Pages = {426-434},
Year = {2013},
Month = {October},
ISSN = {2167-7026},
url = {http://hdl.handle.net/10161/9766 Duke open
access},
Abstract = {We examined the frequency and impact of exposure to
potentially traumatic events among a nonclinical sample of
older adults (n = 3,575), a population typically
underrepresented in epidemiological research concerning the
prevalence of traumatic events. Current PTSD symptom
severity and the centrality of events to identity were
assessed for events nominated as currently most distressing.
Approximately 90% of participants experienced one or more
potentially traumatic events. Events that occurred with
greater frequency early in the life course were associated
with more severe PTSD symptoms compared to events that
occurred with greater frequency during later decades. Early
life traumas, however, were not more central to identity.
Results underscore the differential impact of traumatic
events experienced throughout the life course. We conclude
with suggestions for further research concerning mechanisms
that promote the persistence of post-traumatic stress
related to early life traumas and empirical evaluation of
psychotherapeutic treatments for older adults with
PTSD.},
Doi = {10.1177/2167702613485076},
Key = {fds276059}
}
@article{fds276062,
Author = {Harris, KM and Halpern, CT and Hussey, J and Whitsel, EA and Killeya-Jones, L and Tabor, J and Elder, G and Hewitt, J and Shanahan,
M and Williams, R and Siegler, I and Smolen, A},
Title = {Social, behavioral, and genetic linkages from adolescence
into adulthood.},
Journal = {Am J Public Health},
Volume = {103 Suppl 1},
Number = {Suppl 1},
Pages = {S25-S32},
Year = {2013},
Month = {October},
ISSN = {0090-0036},
url = {http://dx.doi.org/10.2105/AJPH.2012.301181},
Abstract = {The influence of genetic factors on health and behavior is
conditioned by social, cultural, institutional, and physical
environments in which individuals live, work, and play. We
encourage studies supporting multilevel integrative
approaches to understanding these contributions to health,
and describe the Add Health study as an exemplar. Add Health
is a large sample of US adolescents in grades 7 to 12 in
1994-1995 followed into adulthood with 4 in-home interviews
and biomarker collections, including DNA. In addition to
sampling multiple environments and measuring diverse social
and health behavior, Add Health features a fully articulated
behavioral genetic sample (3000 pairs) and ongoing
genotyping of 12,000 archived samples. We illustrate
approaches to understanding health through investigation of
the interplay among biological, psychosocial, and physical,
contextual, or cultural experiences.},
Doi = {10.2105/AJPH.2012.301181},
Key = {fds276062}
}
@article{fds276073,
Author = {Siegler, IC and Brummett, BH and Martin, P and Helms,
MJ},
Title = {Consistency and timing of marital transitions and survival
during midlife: the role of personality and health risk
behaviors.},
Journal = {Annals of Behavioral Medicine : a Publication of the Society
of Behavioral Medicine},
Volume = {45},
Number = {3},
Pages = {338-347},
Year = {2013},
Month = {June},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23299546},
Abstract = {BACKGROUND: Marital status is associated with survival.
PURPOSE: The aims of this study are to evaluate marital
history and timing on mortality during midlife, test the
role of pre-marital personality, and quantify the role of
health risk behaviors. METHODS: Cox proportional hazard
models were run with varying classifications of marital
history and sets of covariates. RESULTS: In fully adjusted
models compared to the currently married, lifetime marital
history predicts premature mortality with never married at
2.33 times risk of death and ever married at 1.64 risk of
death. Midlife marital history shows that not having a
partner during midlife (hazard ratio (HR) = 3.10
formerly married; HR = 2.59 remaining single) has the
highest risk of death. Controlling for personality and
health risk behaviors reduces but does not eliminate the
impact of marital status. CONCLUSION: Consistency of marital
status during midlife suggests that lack of a partner is
associated with midlife mortality.},
Doi = {10.1007/s12160-012-9457-3},
Key = {fds276073}
}
@article{fds276068,
Author = {Martin, P and MacDonald, M and Margrett, J and Siegler, I and Poon, LW and Jazwinski, SM and Green, RC and Gearing, M and Markesbery, WR and Woodard, JL and Johnson, MA and Tenover, JS and Rodgers, WL and Hausman,
DB and Rott, C and Davey, A and Arnold, J},
Title = {Correlates of functional capacity among centenarians.},
Journal = {J Appl Gerontol},
Volume = {32},
Number = {3},
Pages = {324-346},
Year = {2013},
Month = {April},
ISSN = {0733-4648},
url = {http://dx.doi.org/10.1177/0733464811420563},
Abstract = {This study investigated correlates of functional capacity
among participants of the Georgia Centenarian Study. Six
domains (demographics and health, positive and negative
affect, personality, social and economic support, life
events and coping, distal influences) were related to
functional capacity for 234 centenarians and near
centenarians (i.e., 98 years and older). Data were provided
by proxy informants. Domain-specific multiple regression
analyses suggested that younger centenarians, those living
in the community and rated to be in better health were more
likely to have higher functional capacity scores. Higher
scores in positive affect, conscientiousness, social
provisions, religious coping, and engaged lifestyle were
also associated with higher levels of functional capacity.
The results suggest that functional capacity levels continue
to be associated with age after 100 years of life and that
positive affect levels and past lifestyle activities as
reported by proxies are salient factors of adaptation in
very late life.},
Doi = {10.1177/0733464811420563},
Key = {fds276068}
}
@article{fds276071,
Author = {Jiang, R and Brummett, BH and Hauser, ER and Babyak, MA and Siegler, IC and Singh, A and Astrup, A and Pedersen, O and Hansen, T and Holst, C and Sørensen, TIA and Williams, RB},
Title = {Chronic family stress moderates the association between a
TOMM40 variant and triglyceride levels in two independent
Caucasian samples.},
Journal = {Biol Psychol},
Volume = {93},
Number = {1},
Pages = {184-189},
Year = {2013},
Month = {April},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23435269},
Abstract = {TOMM40 SNP rs157580 has been associated with triglyceride
levels in genome-wide association studies (GWAS). Chronic
caregiving stress moderates the association between
triglyceride levels and a nearby SNP rs439401 that is
associated with triglyceride levels in GWAS. Here, we report
data from two independent Caucasian samples (242 U.S. women
and men; 466 Danish men) testing the hypothesis that chronic
family stress also moderates the association between
rs157580 and triglyceride levels. The interaction of
rs157580 and family stress in predicting triglyceride levels
was statistically significant in the U.S. sample (p=0.004)
and marginally significant (p=0.075) in the Danish sample.
The G allele of rs157580 was associated with increased
triglyceride levels among family stressed cases in both
samples compared with A/A cases, but not among controls.
Chronic family stress moderates the association of rs157580
variants with triglyceride levels and should be taken into
account for disease risk assessment and potential
intervention.},
Doi = {10.1016/j.biopsycho.2013.02.006},
Key = {fds276071}
}
@article{fds276221,
Author = {Jiang, R and Brummett, BH and Babyak, MA and Siegler, IC and Williams,
RB},
Title = {Brain-derived neurotrophic factor (BDNF) Val66Met and
adulthood chronic stress interact to affect depressive
symptoms.},
Journal = {J Psychiatr Res},
Volume = {47},
Number = {2},
Pages = {233-239},
Year = {2013},
Month = {February},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23140671},
Abstract = {BACKGROUND: BDNF Val66Met by chronic stress interaction has
been studied using childhood stress as a moderator, but has
not been widely studied using chronic stress in adulthood.
METHODS: Two independent samples were used: Duke-CG (238
Caucasians) and MESA (5524 Caucasians, African Americans and
Hispanics). Chronic stress in Duke-CG was operationalized as
having primary caregiving responsibility for a spouse or
relative with diagnosed Alzheimer's disease or other major
dementia; chronic stress in MESA was defined using chronic
burden score constructed from self-reported problems of
health (self and someone close), job, finance and
relationships. CES-D scale was the measure of depression in
both samples. The BDNF Val66Met by adulthood chronic stress
interaction predicting CES-D was examined using linear
regression, adjusted for covariates. RESULTS: The main
effect of BDNF Val66Met genotype on CES-D scores was
non-significant (ps > 0.607) but the adulthood chronic
stress indicator was significant (ps < 0.001) in both
samples. The BDNF Val66Met genotype by adulthood chronic
stress interaction was also significant (ps < 0.039) in both
samples. The impact of chronic stress in adulthood on CES-D
scores was significantly larger in Val/Val genotype
individuals than Met carriers. CONCLUSION: We found in two
independent samples that depression levels increased
significantly more as a function of adulthood chronic stress
Val/Val genotype carriers than Met carriers. Individuals
with the Val/Val genotype and chronic stress exposure could
be targeted for interventions designed to reduce risk of
depression if this finding is confirmed in future
studies.},
Doi = {10.1016/j.jpsychires.2012.10.009},
Key = {fds276221}
}
@article{fds355734,
Author = {Brummett, BH and Austin, SB and Welsh-Bohmer, KA and Williams, RB and Siegler, IC},
Title = {Long-Term Impact of Caregiving and Metabolic Syndrome with
Perceived Decline in Cognitive Function 8 Years Later: A
Pilot Study Suggesting Important Avenues for Future
Research.},
Journal = {Open Journal of Medical Psychology},
Volume = {2},
Number = {1},
Pages = {23-28},
Year = {2013},
Month = {January},
url = {http://dx.doi.org/10.4236/ojmp.2013.21005},
Abstract = {The chronic stress of caregiving has been associated with
increased risk for cognitive decline and dementia. One
theoretical model suggests that a group of risk factors
known as the metabolic syndrome MET_SYN (e.g. hypertension,
poor glucose regulation, central obesity, and high
triglyceride levels) that have demonstrated associations
with both stress and cognitive decline, may mediate the
association between caregiver stress and cognitive decline.
It is also possible that caregiving may moderate the
association between MET_SYN and cognitive decline. The
present study examined these two potential models. The study
sample consisted of 53 caregivers for a relative with
dementia and 24 participants who did not have caregiving
responsibilities at baseline. We examined associations among
caregiving history (yes/no), self-reported decline in
cognitive function (the AD8) at follow-up, and a MET_SYN
factor comprised of increased systolic blood pressure (SBP),
glycosylated hemoglobin concentration (HbA1c), waist
circumference, and triglyceride levels at baseline when
caregiving was assessed. MET_SYN was associated with AD8 (p
= 0.010). Caregiving history was not directly associated
with AD8 ratings, however, caregiving did moderate the
association between MET_SYN and AD8 (p = 0.043) assessed 8
years later. In caregivers MET_SYN scores reflecting higher
risk were associated with scores on the AD8 indicting
decline, whereas, in controls MET_SYN was unrelated to AD8
assessment. Thus, it can be concluded that caregiver stress
may increase the association between metabolic risk factors
and decline in cognitive functioning up to 8 years
later.},
Doi = {10.4236/ojmp.2013.21005},
Key = {fds355734}
}
@article{fds276057,
Author = {Brummett, BH and Babyak, MA and Jiang, R and Shah, SH and Becker, RC and Haynes, C and Chryst-Ladd, M and Craig, DM and Hauser, ER and Siegler,
IC and Kuhn, CM and Singh, A and Williams, RB},
Title = {A functional polymorphism in the 5HTR2C gene associated with
stress responses also predicts incident cardiovascular
events.},
Journal = {Plos One},
Volume = {8},
Number = {12},
Pages = {e82781},
Editor = {Ahuja, SK},
Year = {2013},
url = {http://hdl.handle.net/10161/8293 Duke open
access},
Abstract = {Previously we have shown that a functional nonsynonymous
single nucleotide polymorphism (rs6318) of the 5HTR2C gene
located on the X-chromosome is associated with
hypothalamic-pituitary-adrenal axis response to a stress
recall task, and with endophenotypes associated with
cardiovascular disease (CVD). These findings suggest that
individuals carrying the rs6318 Ser23 C allele will be at
higher risk for CVD compared to Cys23 G allele carriers. The
present study examined allelic variation in rs6318 as a
predictor of coronary artery disease (CAD) severity and a
composite endpoint of all-cause mortality or myocardial
infarction (MI) among Caucasian participants consecutively
recruited through the cardiac catheterization laboratory at
Duke University Hospital (Durham, NC) as part of the CATHGEN
biorepository. Study population consisted of 6,126 Caucasian
participants (4,036 [65.9%] males and 2,090 [34.1%]
females). A total of 1,769 events occurred (1,544 deaths and
225 MIs; median follow-up time = 5.3 years, interquartile
range = 3.3-8.2). Unadjusted Cox time-to-event regression
models showed, compared to Cys23 G carriers, males
hemizygous for Ser23 C and females homozygous for Ser23C
were at increased risk for the composite endpoint of
all-cause death or MI: Hazard Ratio (HR) = 1.47, 95%
confidence interval (CI) = 1.17, 1.84, p = .0008. Adjusting
for age, rs6318 genotype was not related to body mass index,
diabetes, hypertension, dyslipidemia, smoking history,
number of diseased coronary arteries, or left ventricular
ejection fraction in either males or females. After
adjustment for these covariates the estimate for the two
Ser23 C groups was modestly attenuated, but remained
statistically significant: HR = 1.38, 95% CI = 1.10, 1.73, p
= .005. These findings suggest that this functional
polymorphism of the 5HTR2C gene is associated with increased
risk for CVD mortality and morbidity, but this association
is apparently not explained by the association of rs6318
with traditional risk factors or conventional markers of
atherosclerotic disease.},
Doi = {10.1371/journal.pone.0082781},
Key = {fds276057}
}
@article{fds276063,
Author = {Brummett, BH and Babyak, MA and Singh, A and Jiang, R and Williams, RB and Harris, KM and Siegler, IC},
Title = {Socioeconomic indices as independent correlates of
C-reactive protein in the National Longitudinal Study of
Adolescent Health.},
Journal = {Psychosom Med},
Volume = {75},
Number = {9},
Pages = {882-893},
Year = {2013},
url = {http://www.ncbi.nlm.nih.gov/pubmed/24163384},
Abstract = {OBJECTIVES: To examine the association between socioeconomic
status (SES) and C-reactive protein (CRP) to understand how
SES may increase the risk of cardiovascular disease and thus
identify targets for prevention measures. METHODS: Path
models were used to examine direct and indirect associations
of four indices of SES (objective early life built
environment ratings, parental and participant education, and
income) with CRP measured during early adulthood using data
from the National Longitudinal Adolescent Health Study (n =
11,371; mean age = 29 years, range = 24-32 years; 53.8%
women, 28.0% black participants). The present study examined
potential mediation of the association of SES with CRP by
way of body mass index (BMI), smoking, and alcohol
consumption within white and black men and women. RESULTS:
BMI was a mediator of the relation between parent education
and CRP for white men (path coefficient [γ] = -0.05, p <
.001) and women (γ = -0.05, p < .001). Smoking mediated the
income-CRP (γ = -0.01, p < .01) and the education-CRP (γ =
-0.07, p < .001) relation for white men. BMI mediated the
relation between all measures of SES and CRP for white women
(γ values between -0.02 and -0.05; p values < .01). None of
the risk factors mediated the SES-CRP relation in black
participants. CONCLUSIONS: These findings indicate that the
association of SES with CRP is influenced by both the timing
and type of SES measure examined. In addition, race and sex
play a role in how potential mediators are involved with the
SES-CRP relationship, such that BMI and smoking were
mediators in white men, whereas BMI was the sole mediator in
white women.},
Doi = {10.1097/PSY.0000000000000005},
Key = {fds276063}
}
@article{fds276232,
Author = {Jonassaint, CR and Ashley-Koch, A and Whitfield, KE and Hoyle, RH and Richman, LS and Siegler, IC and Royal, CD and Williams,
R},
Title = {The serotonin transporter gene polymorphism (5HTTLPR)
moderates the effect of adolescent environmental conditions
on self-esteem in young adulthood: a structural equation
modeling approach.},
Journal = {Biol Psychol},
Volume = {91},
Number = {1},
Pages = {111-119},
Year = {2012},
Month = {September},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22659377},
Abstract = {Here we examine the effects of both self-reported and
independent observer-reported environmental risk indices,
the serotonin transporter gene promoter (5HTTLPR)
polymorphism, and their interaction on self-esteem. This
trait was assessed during early and mid adolescence (mean
age=14 and 16.5, respectively) and young adulthood (mean
age=21.8) in a prospective cohort of 1214 unrelated
participants in the Longitudinal Study of Adolescent Health
(Add Health). Using structural equation modeling we
identified a gene-environment (G×E) interaction using
observer-report but not self-report measures of
environmental stress exposure during adolescence: 5HTTLPR
genotype and observer-reports of home and neighborhood
quality (HNQ) during adolescence interacted to predict
self-esteem levels in young adulthood (p<.004). Carriers of
the s allele who lived in poor HNQ conditions during
adolescence reported lower self-esteem in young adulthood
than those with a good HNQ during adolescence. In contrast,
among individuals with the l/l genotype, adolescent HNQ did
not predict adulthood self-esteem. Genes may moderate the
effect of adolescent environmental conditions on adulthood
self-esteem.},
Doi = {10.1016/j.biopsycho.2012.05.004},
Key = {fds276232}
}
@article{fds276060,
Author = {Siegler, IC and Davey, A},
Title = {Behavioral Stability and Change in Health Across the Adult
Life Cycle},
Pages = {118-131},
Publisher = {WILEY-BLACKWELL},
Year = {2012},
Month = {July},
url = {http://dx.doi.org/10.1002/9781118392966.ch6},
Doi = {10.1002/9781118392966.ch6},
Key = {fds276060}
}
@article{fds276248,
Author = {Fuemmeler, BF and Yang, C and Costanzo, P and Hoyle, RH and Siegler, IC and Williams, RB and Ostbye, T},
Title = {Parenting styles and body mass index trajectories from
adolescence to adulthood.},
Journal = {Health Psychology},
Volume = {31},
Number = {4},
Pages = {441-449},
Year = {2012},
Month = {July},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22545979},
Abstract = {OBJECTIVE: Parenting styles such as authoritarian,
disengaged, or permissive are thought to be associated with
greater adolescent obesity risk than an authoritative style.
This study assessed the relationship between parenting
styles and changes in body mass index (BMI) from adolescence
to young adulthood. METHOD: The study included self-reported
data from adolescents in the National Longitudinal Study of
Adolescent Health. Factor mixture modeling, a data-driven
approach, was used to classify participants into parenting
style groups based on measures of acceptance and control.
Latent growth modeling (LGM) identified patterns of
developmental changes in BMI. After a number of potential
confounders were controlled for, parenting style variables
were entered as predictors of BMI trajectories. Analyses
were also conducted for male and female individuals of 3
racial-ethnic groups (Hispanic, black, white) to assess
whether parenting styles were differentially associated with
BMI trajectories in these 6 groups. RESULTS: Parenting
styles were classified into 4 groups: authoritarian,
disengaged, permissive, and balanced. Compared with the
balanced parenting style, authoritarian and disengaged
parenting styles were associated with a less steep average
BMI increase (linear slope) over time, but also less
leveling off (quadratic) of BMI over time. Differences in
BMI trajectories were observed for various genders and
races, but the differences did not reach statistical
significance. CONCLUSION: Adolescents who reported having
parents with authoritarian or disengaged parenting styles
had greater increases in BMI as they transitioned to young
adulthood despite having a lower BMI trajectory through
adolescence.},
Doi = {10.1037/a0027927},
Key = {fds276248}
}
@article{fds276180,
Author = {Brummett, BH and Siegler, IC and Williams, RB and Dilworth-Anderson,
P},
Title = {Associations of Social Support and 8-Year Follow-Up
Depressive Symptoms: Differences in African American and
White Caregivers.},
Journal = {Clinical Gerontologist},
Volume = {35},
Number = {4},
Pages = {289-302},
Year = {2012},
Month = {June},
ISSN = {0731-7115},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23144529},
Abstract = {The present study used data from the Alzheimer's Study of
Emotions in Caregivers (ASEC) to evaluate perceptions of
social support assessed at baseline, as well as changes in
social support assessed at a follow-up eight-years later, as
predictors of symptoms of change in depression, with a focus
on race as a potential moderator of these relationships.
Specifically, multiple regression analyses adjusted for age,
sex, income, education, race, living arrangement of care
recipient at baseline, death of care recipient, the cultural
justification for caregiving scale (CJCS), and baseline
depressive symptoms were conducted to assess baseline social
support ratings, as well as the change in social support
over time as a predictor of depression at follow-up-with a
focus on moderation by race. Baseline social support
(F(1,77) = 7.60, p=.008) was associated with fewer
depressive symptoms at follow-up for all participants. The
change in social support over time was also related to
depressive symptoms, with effects moderated by race (F(1,77)
= 7.97, p = .007), such that when support decreased over
time depressive symptoms at follow-up were higher for
Whites, as compared with African Americans, whereas, when
social support increased over time depressive symptoms
tended to be similar for both groups. These findings
indicate that research designed to plan interventions in
caregivers must not ignore potential racial differences with
regard to the effects of caregiving on mental
health.},
Doi = {10.1080/07317115.2012.678569},
Key = {fds276180}
}
@article{fds276133,
Author = {Poon, LW and Woodard, JL and Stephen Miller and L and Green, R and Gearing,
M and Davey, A and Arnold, J and Martin, P and Siegler, IC and Nahapetyan,
L and Kim, YS and Markesbery, W},
Title = {Understanding dementia prevalence among centenarians.},
Journal = {J Gerontol a Biol Sci Med Sci},
Volume = {67},
Number = {4},
Pages = {358-365},
Year = {2012},
Month = {April},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22389466},
Abstract = {The goals of this article are to (a) establish the
concurrent and clinical validity of the Global Deterioration
scale in assessing cognitive functions and stages of
dementia among centenarians, (b) identify the prevalence of
all-cause dementia in representative samples of
centenarians, and (c) demonstrate how variations in sample
demographic characteristics could significantly affect
estimates of dementia prevalence. A quarter of the 244
centenarians in a population-based sample had no objective
evidence of memory deficits. Another quarter showed signs of
transient confusion, and about half showed classical
behavioral signs of dementia with about 15% in each of
Global Deterioration scale stages 4-6 and about 5% in the
most severe stage 7. Variations in age, gender, race,
residence status, and education of the study sample as well
as criteria used for dementia rating were found to affect
prevalence.},
Doi = {10.1093/gerona/glr250},
Key = {fds276133}
}
@article{fds276134,
Author = {Davey, A and Lele, U and Elias, MF and Dore, GA and Siegler, IC and Johnson, MA and Hausman, DB and Tenover, JL and Poon, LW and Georgia
Centenarian Study},
Title = {Diabetes mellitus in centenarians.},
Journal = {Journal of the American Geriatrics Society},
Volume = {60},
Number = {3},
Pages = {468-473},
Year = {2012},
Month = {March},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22283370},
Abstract = {OBJECTIVES: To describe the prevalence of diabetes mellitus
(DM) in centenarians. DESIGN: Cross-sectional,
population-based. SETTING: Forty-four counties in northern
Georgia. PARTICIPANTS: Two hundred forty-four centenarians
(aged 98-108, 15.8% male, 20.5% African American, 38.0%
community dwelling) from the Georgia Centenarian Study
(2001-2009). MEASUREMENTS: Nonfasting blood samples assessed
glycosylated hemoglobin (HbA(1c)) and relevant clinical
parameters. Demographic, diagnosis, and DM complication
covariates were assessed. RESULTS: 12.5% of centenarians
were known to have DM. DM was more prevalent in African
Americans (27.7%) than whites (8.6%, P < .001). There were
no differences between men (16.7%) and women (11.7%, P =
.41) or between centenarians living in the community (10.2%)
and in facilities (13.9%, P = .54). DM was more prevalent in
overweight and obese (23.1%) than nonoverweight (7.1%, P =
.002) centenarians. Anemia (78.6% vs 48.3%, P = .004) and
hypertension (79.3% vs 58.6%, P = .04) were more prevalent
in centenarians with DM than in those without, and
centenarians with DM took more nonhypoglycemic medications
(8.6 vs 7.0, P = .02). No centenarians with HbA(1c) of less
than 6.5% had random serum glucose levels greater than 200
mg/dL. DM was not associated with 12-month all-cause
mortality, visual impairment, amputations, cardiovascular
disease, or neuropathy. Thirty-seven percent of centenarians
reported onset before age 80 (survivors), 47% between age 80
and 97 (delayers), and 15% aged 98 and older (escapers).
CONCLUSION: Diabetes mellitus is a risk factor for
cardiovascular disease and mortality but is seen in persons
who live into very old age. Aside from higher rates of
anemia and use of more medications, few clinical correlates
of DM were observed in centenarians.},
Doi = {10.1111/j.1532-5415.2011.03836.x},
Key = {fds276134}
}
@article{fds276220,
Author = {Brummett, BH and Babyak, MB and Siegler, IC and Surwit, R and Georgiades, A and Boyle, SH and Williams, RB},
Title = {Systolic blood pressure and adiposity: examination by race
and gender in a nationally representative sample of young
adults.},
Journal = {Am J Hypertens},
Volume = {25},
Number = {2},
Pages = {140-144},
Year = {2012},
Month = {February},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21976277},
Abstract = {BACKGROUND: Adiposity, or more specifically, underlying body
fat distribution, has been associated with systolic blood
pressure (SBP), and it has been suggested that these
associations vary between whites and blacks, as well as by
gender. METHODS: Here, we use data from the National
Longitudinal Study of Adolescent Health (Add Health), a US
study of over 15,000 participants (median age 29.0 years),
to characterize the associations between measures of body
fat distribution-waist circumference (WC) and WC adjusted
for body mass index (BMI) (WC(-bmi))-with SBP within white
and black race and gender subgroups. RESULTS: Our findings
suggest that, at lower levels of WC(-bmi), white women have
significantly higher SBP as compared to black women, whereas
black men have higher SBP than white men. Black women with
WC(-bmi) >90 cm have higher SBP compared to white women with
similar WC(-bmi), whereas among black and white men the
associations are essentially similar across the full range
of WC(-bmi). CONCLUSIONS: The present results suggest that
associations among anthropometric measures of adiposity and
blood pressure are nonlinear, and importantly, vary for
whites and blacks by gender. In black women, SBP increased
more as WC increased from low- to mid-range levels, whereas
it was only at higher WC levels that black men exhibited
higher SBP than white men.},
Doi = {10.1038/ajh.2011.177},
Key = {fds276220}
}
@article{fds276218,
Author = {Brummett, BH and Kuhn, CM and Boyle, SH and Babyak, MA and Siegler, IC and Williams, RB},
Title = {Cortisol responses to emotional stress in men: association
with a functional polymorphism in the 5HTR2C
gene.},
Journal = {Biol Psychol},
Volume = {89},
Number = {1},
Pages = {94-98},
Year = {2012},
Month = {January},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21967853},
Abstract = {The serotonin 5HTR2C receptor has been shown to mediate HPA
axis activation during stress. We hypothesized that a
functional polymorphism (rs6318) of the 5HTR2C gene would be
associated with HPA axis response to a laboratory stress
protocol. The present sample consisted of 41 men (22 African
Americans, 19 Caucasians). We found that at rest men with
the more active rs6318 Ser23 C allele had similar cortisol
values compared to those with the less active Cys23 G
allele. During laboratory stress, however, men with the
Ser23 C allele exhibited the predicted significantly higher
cortisol levels (p<0.001), as well as larger increases in
anger (p=0.08) and depressive mood (p=0.006) ratings,
compared to the Cys23 G carriers. The increase in cortisol
was significantly related to the increases in ratings of
anger and depression assessed before and after the emotion
induction, and these correlations became nonsignificant when
rs6318 genotype was covaried. We conclude that genetic
variation in 5HTR2C may be associated with HPA axis
activation and stimulated by emotional stress, and also with
both psychological and physiological endophenotypes that
increase the risk of cardiovascular disease and type-2
diabetes.},
Doi = {10.1016/j.biopsycho.2011.09.013},
Key = {fds276218}
}
@article{fds276132,
Author = {Hensley, B and Martin, P and Margrett, JA and MacDonald, M and Siegler,
IC and Poon, LW and Jazwinski, SM and Green, RC and Gearing, M and Woodard,
JL and Johnson, MA and Tenover, JS and Rodgers, WL and Hausman, DB and Rott, C and Davey, A and Arnold, J},
Title = {Life events and personality predicting loneliness among
centenarians: findings from the Georgia Centenarian
Study.},
Journal = {The Journal of Psychology},
Volume = {146},
Number = {1-2},
Pages = {173-188},
Year = {2012},
ISSN = {0022-3980},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22303619},
Abstract = {Regarding the purpose of this study, the researchers
analyzed the roles that both life events (life-time positive
events and life-time negative events) and personality
(Neuroticism, Extraversion, Trust, Competence, and Ideas)
played in participants of the Georgia Centenarian Study. The
researchers analyzed these variables to determine whether
they predicted loneliness. Analyses indicated that life-time
negative events significantly predicted loneliness. In
essence, the higher was the number of life-time negative
life events, the higher was the loneliness score. Moreover,
Neuroticism, Competence, and Ideas were all significant
predictors of loneliness. The higher was the level of
Neuroticism and intellectual curiosity, the higher was the
level of loneliness, whereas the lower was the level of
Competence, the higher was the level of loneliness. In
addition, both life-time positive and life-time negative
life events were significant predictors of Neuroticism. The
higher was the number of life-time positive events, the
lower was the level of Neuroticism, and the higher was the
number of life-time negative events, the greater was the
level of Neuroticism. These results indicated that life-time
negative events indirectly affect loneliness via
Neuroticism. Last, our results indicated that the Competence
facet mediated the relationship between lifetime negative
life events and loneliness. Life-time negative life events
significantly affected centenarians' perceived competence,
and Competence in turn significantly affected the
centenarians' loneliness. These results as a whole not only
add to our understanding of the link between personality and
loneliness, but also provide new insight into how life
events predict loneliness.},
Doi = {10.1080/00223980.2011.613874},
Key = {fds276132}
}
@article{fds276136,
Author = {Berntsen, D and Rubin, DC and Siegler, IC},
Title = {Two versions of life: emotionally negative and positive life
events have different roles in the organization of life
story and identity.},
Journal = {Emotion},
Volume = {11},
Number = {5},
Pages = {1190-1201},
Year = {2011},
Month = {October},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21875191},
Abstract = {Over 2,000 adults in their sixties completed the Centrality
of Event Scale (CES) for the traumatic or negative event
that now troubled them the most and for their most positive
life event, as well as measures of current PTSD symptoms,
depression, well-being, and personality. Consistent with the
notion of a positivity bias in old age, the positive events
were judged to be markedly more central to life story and
identity than were the negative events. The centrality of
positive events was unrelated to measures of PTSD symptoms
and emotional distress, whereas the centrality of the
negative event showed clear positive correlations with these
measures. The centrality of the positive events increased
with increasing time since the events, whereas the
centrality of the negative events decreased. The life
distribution of the positive events showed a marked peak in
young adulthood whereas the life distribution for the
negative events peaked at the participants' present age. The
positive events were mostly events from the cultural life
script-that is, culturally shared representations of the
timing of major transitional events. Overall, our findings
show that positive and negative autobiographical events
relate markedly differently to life story and identity.
Positive events become central to life story and identity
primarily through their correspondence with cultural norms.
Negative events become central through mechanisms associated
with emotional distress.},
Doi = {10.1037/a0024940},
Key = {fds276136}
}
@article{fds276219,
Author = {Brummett, BH and Babyak, MA and Siegler, IC and Shanahan, M and Harris,
KM and Elder, GH and Williams, RB},
Title = {Systolic blood pressure, socioeconomic status, and
biobehavioral risk factors in a nationally representative US
young adult sample.},
Journal = {Hypertension},
Volume = {58},
Number = {2},
Pages = {161-166},
Year = {2011},
Month = {August},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21730296},
Abstract = {In the National Longitudinal Study of Adolescent Health, a
US longitudinal study of >15 000 young adults, we examined
the extent to which socioeconomic status is linked to
systolic blood pressure (SBP) and whether biobehavioral risk
factors mediate the association. More than 62% of the
participants had SBP >120 mm Hg and 12% had SBP >140 mm Hg.
More than 66% were classified as at least overweight (body
mass index >25 kg/m(2)), with >36% meeting criteria for at
least class I obesity (body mass index >30 kg/m(2)).
Multivariate models showed that higher household income and
being married were independently associated with lower SBP.
Higher body mass index, greater waist circumference,
smoking, and higher alcohol intake were each independently
associated with higher SBP. Meditational analyses suggested
that higher education level was associated with lower SBP by
way of lower body mass, smaller waist circumference, and
lower resting heart rate. When these indirect effects were
accounted for, education was not significantly associated
with SBP. In contrast, household income remained associated
with SBP even with control for all of the covariates.
Results reinforce current public health concerns about rates
of obesity and high blood pressure among young adults and
suggest that disparities in education level and household
income may play an important role in the observed decrements
in health. Identifying modifiable mechanisms that link
socioeconomic status to SBP using data from a large
representative sample may improve risk stratification and
guide the development of effective interventions.},
Doi = {10.1161/HYPERTENSIONAHA.111.171272},
Key = {fds276219}
}
@article{fds276179,
Author = {Barefoot, JC and Brummett, BH and Williams, RB and Siegler, IC and Helms, MJ and Boyle, SH and Clapp-Channing, NE and Mark,
DB},
Title = {Recovery expectations and long-term prognosis of patients
with coronary heart disease.},
Journal = {Arch Intern Med},
Volume = {171},
Number = {10},
Pages = {929-935},
Year = {2011},
Month = {May},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21357800},
Abstract = {BACKGROUND: Expectations of patients regarding their
prospects for recovery have been shown to predict subsequent
physical and social functioning. Evidence regarding the
impact of expectations on clinical outcomes is limited.
METHODS: At the inpatient service of a tertiary care
hospital, we evaluated beliefs of patients undergoing
coronary angiography about their prognosis as predictors of
long-term survival and 1-year functional status. Baseline
assessments, including a measure of expectations for
recovery, were obtained during hospitalization with
mortality follow-up for approximately 15 years. Patients
with significant obstructive coronary artery disease were
interviewed while in the hospital and enrolled in follow-up.
Functional status was assessed at baseline and 1 year later
with questionnaires reflecting physical capabilities.
Analyses controlled for age, sex, disease severity,
comorbidities, treatments, demographics, depressive
symptoms, social support, and functional status. There were
1637 total deaths, 885 from cardiovascular causes, in the
2818 patients in these analyses. The outcomes were total
mortality, cardiovascular mortality, and 1-year functional
status. RESULTS: Expectations were positively associated
with survival after controlling for background and clinical
disease indicators. For a difference equivalent to an
interquartile range of expectations, the hazard ratio (HR)
for total mortality was 0.76 (95% confidence interval [CI],
0.71-0.82) and 0.76 (95% CI, 0.69-0.83) for cardiovascular
mortality. The HRs were 0.83 (95% CI, 0.76-0.91) and 0.79
(95% CI, 0.70-0.89) with further adjustments for demographic
and psychosocial covariates. Similar associations (P < .001)
were observed for functional status. CONCLUSION: Recovery
expectations at baseline were positively associated with
long-term survival and functioning in patients with coronary
artery disease.},
Doi = {10.1001/archinternmed.2011.41},
Key = {fds276179}
}
@article{fds276231,
Author = {Brummett, BH and Siegler, IC and Ashley-Koch, A and Williams,
RB},
Title = {Effects of 5HTTLPR on cardiovascular response to an
emotional stressor.},
Journal = {Psychosom Med},
Volume = {73},
Number = {4},
Pages = {318-322},
Year = {2011},
Month = {May},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21364197},
Abstract = {OBJECTIVES: To replicate a prior main effect of the
serotonin transporter gene promoter (5HTTLPR) genotype on
cardiovascular reactivity (CVR) and explore caregiver stress
as a potential moderator of 5HTTLPR effects on CVR. On the
basis of prior findings, we hypothesized that the more
transcriptionally active allele variants would be associated
with increased CVR. METHODS: Expression of the serotonin
transporter is affected by the genotype of the 5HTTLPR
(S-short and L-long forms) as well as the genotype of the
SNP rs25531 within this region. Based on the combined
genotypes for these polymorphisms, we designated each allele
as a Hi or Lo expressing allele according to expression
levels-resulting in HiHi, HiLo, and LoLo groups. We examined
the relationship between 5HTTLPR genotype and CVR in 164
caregivers and 158 noncaregivers. Main effects of 5HTTLPR on
baseline adjusted blood pressure (systolic and diastolic
blood pressures) and heart rate (HR) reactivity were
examined, along with moderation by caregiving. RESULTS: The
5HTTLPR × Caregiver Stress interaction moderated both
systolic blood pressure (p < .02) and HR (p < .02)
reactivity. In controls, the Hi activity allelic variants
were associated with greater systolic blood pressure and HR
reactivity as compared with the Lo activity variants. In
caregivers, 5HTTLPR genotype was not associated with CVR.
CONCLUSIONS: Replication in this study's control group of
our prior finding that 5HTTLPR alleles associated with Hi
activity are associated with increased CVR to an emotion
recall stressor strengthens the case that this association
is real and could be partially responsible for the increased
cardiovascular disease observed in persons carrying the
5HTTLPR L allele.},
Doi = {10.1097/PSY.0b013e3182118c16},
Key = {fds276231}
}
@article{fds276130,
Author = {Margrett, JA and Daugherty, K and Martin, P and MacDonald, M and Davey,
A and Woodard, JL and Miller, LS and Siegler, IC and Poon,
LW},
Title = {Affect and loneliness among centenarians and the oldest old:
the role of individual and social resources.},
Journal = {Aging Ment Health},
Volume = {15},
Number = {3},
Pages = {385-396},
Year = {2011},
Month = {April},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21491224},
Abstract = {OBJECTIVES: Affect and loneliness are important indicators
of mental health and well-being in older adulthood and are
linked to significant outcomes including physical health and
mortality. Given a large focus on young-old adults within
gerontological research, the primary aim of this study was
to examine the ability of individual and social resources in
predicting affect and loneliness within a sample of
oldest-old individuals including centenarians, an
understudied population. METHODS: Participants were assessed
during the most recent cross-sectional data collection of
the Georgia Centenarian Study. The eligible sample included
55 octogenarians (M = 83.70 years, SD = 2.68; range = 81-90)
and 77 centenarians (M = 99.78 years, SD = 1.64; range =
98-109). Subjects scored 17 or greater on the Mini-Mental
Status Exam and completed mental health assessments.
RESULTS: Hierarchical regression analyses were conducted to
examine the relation of affect and loneliness with
demographic characteristics, physical and social
functioning, cognition, and personality. Within this sample
of cognitively intact oldest old, measures of executive
control and cognitive functioning demonstrated limited
association with mental health. Personality, specifically
neuroticism, was strongly related to mental health
indicators for both age groups and social relations were
particularly important associates of centenarians' mental
health. DISCUSSION: Findings indicate the distinctiveness of
mental health indicators and the need to distinguish
differential roles of individual and social resources in
determining these outcomes among octogenarians and
centenarians.},
Doi = {10.1080/13607863.2010.519327},
Key = {fds276130}
}
@article{fds276152,
Author = {Jonassaint, CR and Siegler, IC and Barefoot, JC and Edwards, CL and Williams, RB},
Title = {Low life course socioeconomic status (SES) is associated
with negative NEO PI-R personality patterns.},
Journal = {International Journal of Behavioral Medicine},
Volume = {18},
Number = {1},
Pages = {13-21},
Year = {2011},
Month = {March},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20012811},
Abstract = {BACKGROUND: Low socioeconomic status (SES) is associated
with poor health. One potential pathway accounting for this
relationship may be an association between low SES and
personality characteristics that affect health. METHODS:
Associations among parent's education, current SES
(education and income), and personality were examined among
233 African Americans and Caucasian, male and female
community volunteers. RESULTS: Using multivariate analysis
of variance (MANOVA) to model neuroticism, extraversion,
openness to experience, agreeableness, and conscientiousness
simultaneously, participant's education, household income,
and father's and mother's education each had significant
main effects on personality. When examining the life
course--the combination of both current and childhood
SES--distinctive patterns emerged for each domain, depending
upon whether mother's or father's education was used to
index childhood SES. When using mother's education as a
childhood SES index, a high life course SES (high
participant's SES/high mother's education) was associated
with high extraversion and openness. Using father's
education as a childhood SES index, a low life course SES
(low participant's SES/low father's education) was
associated with disproportionately high neuroticism and low
conscientiousness. These effects did not differ by race or
sex. CONCLUSION: The implications of these findings for the
role of personality in the SES-health relationship are
discussed.},
Doi = {10.1007/s12529-009-9069-x},
Key = {fds276152}
}
@article{fds276178,
Author = {Iqbal Kring and SI and Barefoot, J and Brummett, BH and Boyle, SH and Siegler, IC and Toubro, S and Hansen, T and Astrup, A and Pedersen, O and Williams, RB and Sørensen, TIA},
Title = {Associations between APOE variants and metabolic traits and
the impact of psychological stress.},
Journal = {Plos One},
Volume = {6},
Number = {1},
Pages = {e15745},
Year = {2011},
Month = {January},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21283811},
Abstract = {OBJECTIVE: In a previous study, we observed that
associations between APOE rs439401 and metabolic traits were
moderated by chronic stress. Thus, in a population of
stressed and non-stressed Danish men, we examined whether
associations between APOE rs439401 and a panel of metabolic
quantitative traits, all metabolic traits which may lead to
T2D and CVD were moderated by psychological stress. METHODS:
Obese young men (n = 475, BMI ≥ 31.0 kg/m(2)) and a
randomly selected control group (n = 709) identified from a
population of 141,800 men were re-examined in two surveys
(S-46: mean age 46, S-49: mean age 49 years) where
anthropometric and biochemical measures were available.
Psychological stress factors were assessed by a
self-administered 7-item questionnaire. Each item had the
possible response categories "yes" and "no" and assessed
familial problems and conflicts. Summing positive responses
constituted a stress item score, which was then dichotomized
into stressed and non-stressed. Logistic regression
analysis, applying a recessive genetic model, was used to
assess odds ratios (OR) of the associations between APOE
rs439401 genotypes and adverse levels of metabolic traits.
RESULTS: The APOE rs439401 TT-genotype associated positively
with BMI (OR = 1.09 [1.01; 1.17]), waist circumference (OR =
1.09 [1.02; 1.17]) in stressed men at S-46. Positive
associations were observed for fasting plasma glucose (OR =
1.42 [1.07; 1.87]), serum triglycerides (OR = 1.41 [1.05;
1.91]) and with fasting plasma insulin (OR = 1.48 [1.05;
2.08]) in stressed men at S-49. Rs439401 TT-genotype also
associated positively with surrogate measures of insulin
resistance (HOMA-IR; OR = 1.21 [1.03; 1.41]) and inversely
with insulin sensitivity (Stumvoll index; OR = 0.90 [0.82;
0.99], BIGTT-S(I); OR = 0.60 [0.43; 0.85]) in stressed men.
No significant associations were observed in non-stressed
men, albeit the estimates showed similar but weaker trends
as in stressed men. CONCLUSION: The present results suggest
that the APOE rs439401 TT-genotype is associated with an
adverse metabolic profile in a population of psychologically
stressed Danish men.},
Doi = {10.1371/journal.pone.0015745},
Key = {fds276178}
}
@article{fds276129,
Author = {Davey, A and Elias, MF and Siegler, IC and Lele, U and Martin, P and Johnson, MA and Hausman, DB and Poon, LW},
Title = {Cognitive function, physical performance, health, and
disease: norms from the georgia centenarian
study.},
Journal = {Experimental Aging Research},
Volume = {36},
Number = {4},
Pages = {394-425},
Year = {2010},
Month = {October},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20845120},
Abstract = {This study provides, for the first time, normative data on
cognitive functioning and physical performance, health and
health behaviors, and diseases from a population-based
sample of 244 centenarians and near-centenarians (M age =
100.5 years, range 98-108, 84.8% women, 21.3% African
American) from the Georgia Centenarian Study. Data are
presented by the four key dimensions of gender, race,
residence, and educational attainment. Results illustrate
the profound range of functioning in this age group and
indicate considerable differences as a function of each
dimension. Bivariate models generally suggest that cognitive
functioning and physical performance is higher for men than
women; whites than African Americans; community than
facility residents; and those with more than high school
education than those with less than high school education.
Multivariate models elaborate that differences in
educational attainment generally account for the largest
proportion of variance in cognitive functioning and
residential status generally accounts for the largest
proportion of variance in physical performance measures.
Addition of health variables seldom increases variance
accounted for in each domain beyond these four
dimensions.},
Doi = {10.1080/0361073X.2010.509010},
Key = {fds276129}
}
@article{fds276177,
Author = {Siegler, IC and Brummett, BH and Williams, RB and Haney, TL and Dilworth-Anderson, P},
Title = {Caregiving, residence, race, and depressive
symptoms.},
Journal = {Aging Ment Health},
Volume = {14},
Number = {7},
Pages = {771-778},
Year = {2010},
Month = {September},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20635234},
Abstract = {The objective of this study is to evaluate the psychological
responses to caregiving between black and white dementia
caregivers measured by self-reports of depressive symptoms
evaluating the impact of sub-components of the Center for
Epidemiologic Studies Depression Scale (CES-D) and
residential arrangements of the caregiving dyad. The method
included 87 intergenerational family caregivers enrolled in
the Duke Caregiver Study (50 white and 37 black). Total
CES-D and the four sub-components were modeled as dependent
measures in separate linear regressions. Three models were
examined. The first model tested race, living arrangements,
and their interaction. The second model adjusted for age,
gender, education, income, health status, cultural
justification for caregiving, crime concerns, systolic blood
pressure, diastolic blood pressure, and glycosylated
hemoglobin. A third model added adjustment for caregiver
burden. The results showed that there was a significant race
by residence interaction for CES-D, somatic symptoms and
depressive affect such that when the dyads are living
apart-with the care recipient in their own home or in an
institutional setting-whites reported more depressive
symptoms than blacks. When the dyads lived together, this
was reversed, and blacks reported higher depressive symptoms
than whites. To conclude, all the parameters such as race,
living arrangements, and the components of depression need
to be taken into account to understand the impact of
caregiving on the emotional health of caregivers.},
Doi = {10.1080/13607861003713257},
Key = {fds276177}
}
@article{fds276230,
Author = {Williams, RB and Surwit, RS and Siegler, IC and Ashley-Koch, AE and Collins, AL and Helms, MJ and Georgiades, A and Boyle, SH and Brummett,
BH and Barefoot, JC and Grichnik, K and Stafford-Smith, M and Suarez,
EC and Kuhn, CM},
Title = {Central nervous system serotonin and clustering of
hostility, psychosocial, metabolic, and cardiovascular
endophenotypes in men.},
Journal = {Psychosom Med},
Volume = {72},
Number = {7},
Pages = {601-607},
Year = {2010},
Month = {September},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20595415},
Abstract = {OBJECTIVE: To use measures of cerebrospinal fluid (CSF)
5-hydroxyindoleacetic acid (5HIAA) and genotype of a
functional polymorphism of the monoamine oxidase A gene
promoter (MAOA-uVNTR) to study the role of central nervous
system (CNS) serotonin in clustering of hostility, other
psychosocial, metabolic and cardiovascular endophenotypes.
METHODS: In 86 healthy male volunteers, we evaluated CSF
levels of the primary serotonin metabolite 5HIAA and
MAOA-uVNTR genotype for association with a panel of 29
variables assessing hostility, other psychosocial,
metabolic, and cardiovascular endophenotypes. RESULTS: The
correlations of 5HIAA with these endophenotypes in men with
more active MAOA-uVNTR alleles were significantly different
from those of men with less active alleles for 15 of the 29
endophenotypes. MAOA-uVNTR genotype and CSF 5HIAA interacted
to explain 20% and 22% of the variance, respectively, in
scores on one factor wherein high scores reflected a less
healthy psychosocial profile and a second factor wherein
high score reflected increased insulin resistance, body mass
index, blood pressure and hostility. In men with less active
alleles, higher 5HIAA was associated with more favorable
profiles of hostility, other psychosocial, metabolic and
cardiovascular endophenotypes; in men with more active
alleles, higher 5HIAA was associated with less favorable
profiles. CONCLUSIONS: These findings indicate that, in men,
indices of CNS serotonin function influence the expression
and clustering of hostility, other psychosocial, metabolic
and cardiovascular endophenotypes that have been shown to
increase risk of developing cardiovascular disease. The
findings are consistent with the hypothesis that increased
CNS serotonin is associated with a more favorable
psychosocial/metabolic/cardiovascular profile, whereas
decreased CNS serotonin function is associated with a less
favorable profile.},
Doi = {10.1097/PSY.0b013e3181eb9d67},
Key = {fds276230}
}
@article{fds276229,
Author = {Kring, SII and Brummett, BH and Barefoot, J and Garrett, ME and Ashley-Koch, AE and Boyle, SH and Siegler, IC and Sørensen, TIA and Williams, RB},
Title = {Impact of psychological stress on the associations between
apolipoprotein E variants and metabolic traits: findings in
an American sample of caregivers and controls.},
Journal = {Psychosom Med},
Volume = {72},
Number = {5},
Pages = {427-433},
Year = {2010},
Month = {June},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20467002},
Abstract = {OBJECTIVE: To examine the association between apolipoprotein
E (APOE) gene variants and waist circumference, fasting
plasma glucose, serum insulin, serum high-density
lipoprotein cholesterol, and serum triglycerides, all
metabolic traits known as cardiovascular disease (CVD)
endophenotypes, in a population of stressed individuals and
controls. Abdominal obesity, insulin resistance, elevated
serum lipid concentration, and APOE polymorphisms have been
associated with CVD risk. Current evidence supports the
hypothesis that gene-environment interactions modulate serum
lipid concentrations. METHODS: The association between
rs769450, rs405509, rs439401, and metabolic traits were
analyzed in a U.S. sample of 126 white caregivers of a
relative with Alzheimer';s disease or other major dementia
and 122 white controls. The associations were analyzed,
using multivariate analysis of variance adjusted for age,
sex, and medications. RESULTS: Significant multivariate
interactions were found, using both additive (p = .009) and
dominant (p = .047) models between rs439401 (C/T) and
caregiver stress in relation to a profile of metabolic
variables. Univariate analyses found the TT genotype to be
associated with more adverse levels of waist circumference
(interaction, p = .026), triglycerides (interaction, p =
.001) and high-density lipoprotein cholesterol (interaction,
p = .001) among caregivers but with a more favorable profile
of these endophenotypes among controls. There were no
significant associations or interactions involving the other
two single nucleotide polymorphisms. CONCLUSION: The APOE
rs439401 TT genotype is associated with an adverse metabolic
profile among chronically stressed individuals compared with
individuals not similarly stressed in whom a more favorable
profile is expressed. Confirmation of these results in
further research would indicate that the TT genotype can be
used to identify persons at high risk for CVD when subjected
to chronic stress.},
Doi = {10.1097/PSY.0b013e3181de30ad},
Key = {fds276229}
}
@article{fds276207,
Author = {Brummett, BH and Boyle, SH and Ortel, TL and Becker, RC and Siegler, IC and Williams, RB},
Title = {Associations of depressive symptoms, trait hostility, and
gender with C-reactive protein and interleukin-6 response
after emotion recall.},
Journal = {Psychosom Med},
Volume = {72},
Number = {4},
Pages = {333-339},
Year = {2010},
Month = {May},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20190126},
Abstract = {OBJECTIVE: To examine the effects of depressive symptoms and
hostility on changes in C-reactive protein (CRP) and
interleukin (IL)-6 in response to an acute laboratory
stressor. Depressive symptoms moderate the effect of trait
hostility on circulating levels of CRP and IL-6. METHODS:
The study included 307 men and 218 women, affording the
opportunity to examine moderation by gender. Regression
analyses were performed to examine depressive symptoms,
hostility ratings, gender, and their interactions as
predictors of CRP and IL-6 response to an emotion recall
task. Analyses were adjusted for age, race, body mass index,
and prerecall task levels of either CRP or IL-6. RESULTS:
The product term for Depressive Symptoms x Hostility x
Gender was not significantly related to CRP nor IL-6
response. However, Depressive Symptoms x Hostility did
interact to predict CRP response (p = .002); those with the
combination of high symptoms of depression and hostility had
the largest CRP response. The Depressive Symptoms x Gender
interaction was also a predictor of both CRP (p = .001) and
IL-6 (p = .04) response; for each inflammatory marker,
depressive symptoms were significantly associated with
higher CRP response in women, as compared with men.
Hostility did not moderate depressive symptoms, nor gender
for IL-6. CONCLUSIONS: Our findings extend prior research by
suggesting that, broadly speaking, depression is related to
inflammatory markers; however, this relationship seems
complex. Depression seems to be related to inflammation more
strongly among hostile individuals and more strongly among
women than among men.},
Doi = {10.1097/PSY.0b013e3181d2f104},
Key = {fds276207}
}
@article{fds276176,
Author = {Brummett, BH and Boyle, SH and Kuhn, CM and Siegler, IC and Williams,
RB},
Title = {Socioeconomic status moderates associations between CNS
serotonin and expression of beta2-integrins CD11b and
CD11c.},
Journal = {J Psychiatr Res},
Volume = {44},
Number = {6},
Pages = {373-377},
Year = {2010},
Month = {April},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19800635},
Abstract = {One of the first steps in the development of atherogenesis
is adhesion of circulating monocytes to the vascular
endothelium that is stimulated by beta(2)-integrins. Stress
has been associated with enhanced expression of
beta(2)-integrins on monocyte cell surface (Greeson et al.,
2008). Central nervous system (CNS) serotonin regulates
aspects of the stress response that can influence
inflammatory processes that increase risk for
atherosclerosis. This study examines effects of an
environmental stressor (indexed by socioeconomic status
(SES)) and CNS serotonin (indexed by CSF 5HIAA level), on
the expression of beta(2)-integrins (CD11a, CD11b, and
CD11c) on circulating monocytes in 131 volunteers.
Participants completed a protocol consisting of a lumbar
puncture for assessment of CSF 5HIAA levels (day 1) followed
by an experimental protocol (day 2). Blood samples for the
present analyses were obtained at baseline on day 2. The
interaction of SES x 5HIAA was a significant predictor of
levels of CD11b and CD11c expression (p=.02, and p=.05,
respectively); the mean CD11b difference between Hi and Lo
SES subjects was significant (p=.003) only in those with Lo
levels of 5HIAA, while SES differences in CD11b among those
with Mid and Hi levels of 5HIAA did not vary statistically.
The pattern of findings was similar for CD11c. The present
results suggest that the combination of high environmental
stress and low CNS serotonin function could contribute to
atherogenesis through processes that lead to increased
expression of the beta(2)-integrins CD11b and CD11c on
monocyte cell surfaces.},
Doi = {10.1016/j.jpsychires.2009.09.004},
Key = {fds276176}
}
@article{fds276127,
Author = {Hooker, K and Hoppmann, C and Siegler, IC},
Title = {Personality: Life span compass for health},
Journal = {Annual Review of Gerontology and Geriatrics},
Volume = {30},
Number = {1},
Pages = {201-232},
Publisher = {Springer Publishing Company},
Year = {2010},
Month = {January},
ISSN = {0198-8794},
url = {http://dx.doi.org/10.1891/0198-8794.30.201},
Abstract = {Personality is crucial for understanding health in later
life. Yet classic conceptions of personality with emphasis
on stability may have limited the empirical attention it
deserved in relation to health. This chapter highlights the
six foci of a personality model that integrates structures
and processes within a level-ofanalysis framework that
affords increased opportunities for health interventions and
changes. The first level of the six-foci model includes
traits, the broad and universal descriptions of a person
that are relatively stable across time, and states, the
moment-to-moment changes a person experiences. The second
level of the six-foci model is composed of personal action
constructs that emphasize the goal directedness of behavior
and the self-regulatory processes involved in working toward
goals. The third level of the six-foci model includes the
life story, and processes of self-narration, such as
remembering, reminiscing, and storytelling necessary for
creating life stories. Brief reviews of relevant health
research and suggestions for future research are highlighted
in the overview. A compass metaphor portrays the dynamics
and overall direction that personality provides for
developmental health trajectories and lives. Results from
the UNC Alumni Heart Study, a long-term longitudinal study
of traits and risk factors for disease and health outcomes,
are reviewed. The emerging literature on personality and its
relationship to Alzheimer's disease is also examined. The
last section of the chapter is a review of
micro-longitudinal, state-like "in situ" studies of
personality and health with dense measurements over more
limited temporal spans. The time-sampling studies require
new methodological approaches that are providing intriguing
new evidence of how personality in context creates health
and increases our understanding of development in adulthood.
© 2010 Springer Publishing Company.},
Doi = {10.1891/0198-8794.30.201},
Key = {fds276127}
}
@article{fds276126,
Author = {Margrett, J and Martin, P and Woodard, JL and Miller, LS and MacDonald,
M and Baenziger, J and Siegler, IC and Davey, A and Poon, L and Georgia
Centenarian Study, and Jazwinski, SM and Green, RC and Gearing, M and Markesbery, WR and Johnson, MA and Tenover, JS and Rodgers, WL and Hausman, DB and Rott, C and Arnold, J},
Title = {Depression among centenarians and the oldest old:
contributions of cognition and personality.},
Journal = {Gerontology},
Volume = {56},
Number = {1},
Pages = {93-99},
Year = {2010},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20110723},
Abstract = {BACKGROUND: An estimated 20% of adults over the age of 55
experience clinical mental disorders such as depression and
anxiety. For older adults, mental health concerns are often
undetected, concomitant with physical challenges, and
ultimately go untreated. These realities have significant
implications for older adults' day-to-day functioning,
particularly among the oldest old. OBJECTIVE: The present
study examined the ability of cognition and personality in
explaining depression within a sample of octogenarians and
centenarians. METHODS: Participants were assessed during the
most recent cross-sectional data collection of the Georgia
Centenarian Study. The final eligible sample included 76
octogenarians (mean: 84.25 years, SD: 2.82; range: 81-90)
and 158 centenarians and near centenarians (mean: 99.82
years, SD: 1.72; range: 98-109). RESULTS: Hierarchical
regression analyses were conducted to examine the relation
between key variables and depressive symptoms in the two age
groups. Blocks entered into the analyses included:
demographics (i.e. age group, residential status, sex, and
ethnicity) and functioning, memory and problem-solving
ability, and personality (i.e. extraversion and
neuroticism). Models differed for octogenarians and
centenarians. Decreased problem-solving ability was related
to greater depressive symptoms among octogenarians. For
centenarians, institutional residence and increased neurotic
tendencies were related to greater depressive symptoms.
CONCLUSION: Study findings demonstrate the need to examine a
variety of factors which influence mental health in later
life and to consider the unique contexts and differential
experiences of octogenarians and centenarians.},
Doi = {10.1159/000272018},
Key = {fds276126}
}
@article{fds276128,
Author = {Arnold, J and Dai, J and Nahapetyan, L and Arte, A and Johnson, MA and Hausman, D and Rodgers, WL and Hensley, R and Martin, P and Macdonald,
M and Davey, A and Siegler, IC and Jazwinski, SM and Poon,
LW},
Title = {Predicting successful aging in a population-based sample of
georgia centenarians.},
Journal = {Curr Gerontol Geriatr Res},
Volume = {2010},
Pages = {989315},
Year = {2010},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20885919},
Abstract = {Used a population-based sample (Georgia Centenarian Study,
GCS), to determine proportions of centenarians reaching 100
years as (1) survivors (43%) of chronic diseases first
experienced between 0-80 years of age, (2) delayers (36%)
with chronic diseases first experienced between 80-98 years
of age, or (3) escapers (17%) with chronic diseases only at
98 years of age or older. Diseases fall into two morbidity
profiles of 11 chronic diseases; one including
cardiovascular disease, cancer, anemia, and osteoporosis,
and another including dementia. Centenarians at risk for
cancer in their lifetime tended to be escapers (73%), while
those at risk for cardiovascular disease tended to be
survivors (24%), delayers (39%), or escapers (32%).
Approximately half (43%) of the centenarians did not
experience dementia. Psychiatric disorders were positively
associated with dementia, but prevalence of depression,
anxiety, and psychoses did not differ significantly between
centenarians and an octogenarian control group. However,
centenarians were higher on the Geriatric Depression Scale
(GDS) than octogenarians. Consistent with our model of
developmental adaptation in aging, distal life events
contribute to predicting survivorship outcome in which
health status as survivor, delayer, or escaper appears as
adaptation variables late in life.},
Doi = {10.1155/2010/989315},
Key = {fds276128}
}
@article{fds276153,
Author = {Jonassaint, CR and Boyle, SH and Kuhn, CM and Siegler, IC and Copeland,
WE and Williams, R},
Title = {Personality and inflammation: the protective effect of
openness to experience.},
Journal = {Ethnicity & Disease},
Volume = {20},
Number = {1},
Pages = {11-14},
Year = {2010},
ISSN = {1049-510X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20178176},
Abstract = {BACKGROUND: Prior research found reduced mortality in
coronary heart patients with higher scores on the Openness
to Experience domain and its facets. Decreased C-reactive
protein level (CRP) levels may be one mechanism by which
higher Openness to Experience leads to decreased mortality.
Thus, the current study aimed to test the association
between the Openness to Experience domain and its facets, as
assessed by the NEO Personality Inventory-Revised, and CRP
in a sample of 165 healthy Black and White, male and female
community volunteers. METHODS: Blood samples were taken
before and after a 40-minute mental stress protocol. BMI and
education were significant predictors of CRP and, in
addition to age, were included as covariates in all
analyses. Race and sex were tested as possible moderating
variables. RESULTS: In a mixed effects model the main effect
of time (pre/post-stress), Openness to Experience (O) and
their interaction were not significant predictors of CRP.
However, results showed a significant race x O effect on CRP
(P=.03). In Blacks, higher Openness to Experience domain
(r=-.41, P<.01), aesthetics facet (r=-.30, P=.01), feelings
facet (r= -.41, P<.01), and ideas facet (r=-.38, P<.01)
scores were associated with lower mean CRP levels. In
contrast, among White participants, neither the Openness to
Experience domain nor its related facets were associated
with CRP. DISCUSSION: The Openness to Experience domain and
its facets may be associated with markers of the
inflammatory process among Blacks but not
Whites.},
Key = {fds276153}
}
@article{fds276125,
Author = {Martin, P and Baenziger, J and Macdonald, M and Siegler, IC and Poon,
LW},
Title = {Engaged Lifestyle, Personality, and Mental Status Among
Centenarians.},
Journal = {Journal of Adult Development},
Volume = {16},
Number = {4},
Pages = {199-208},
Year = {2009},
Month = {December},
ISSN = {1068-0667},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21132076},
Abstract = {This study assessed engaged lifestyle activities (e.g.,
volunteering, traveling, and public speaking) for
centenarians of the Georgia Centenarian Study. A total of
285 centenarians and near-centenarians (i.e., 98 years and
older) and their proxy informants participated in this
study. The Mini-Mental Status Examination (MMSE) was
assessed for all centenarians, and proxy informants reported
on lifestyle activities and personality traits of the
centenarians. Results suggested that participants who had
volunteered, traveled, and those who had given public talks
and balanced their checkbooks were more likely to show
relatively high mental status scores (i.e., MMSE > 17).
Personality traits were found to be moderators in the
relationship between engaged lifestyle and mental status:
Participants with high levels of Emotional Stability,
Extraversion, Openness, and Conscientiousness and with high
levels of engaged lifestyle were more likely to show
relatively high mental status scores (i.e., MMSE > 17),
whereas participants with low levels of Emotional Stability,
Extraversion, Openness, Agreeableness, and Conscientiousness
and with low levels of engaged lifestyle were more likely to
show relatively low mental status scores (i.e., MMSE < 18).
The results suggest that engaged lifestyle, particularly in
combination with personality traits, plays an important role
in the level of cognitive functioning among oldest old
adults.},
Doi = {10.1007/s10804-009-9066-y},
Key = {fds276125}
}
@article{fds276174,
Author = {Georgiades, A and Lane, JD and Boyle, SH and Brummett, BH and Barefoot,
JC and Kuhn, CM and Feinglos, MN and Williams, RB and Merwin, R and Minda,
S and Siegler, IC and Suarez, EC and Surwit, RS},
Title = {Hostility and fasting glucose in African American
women.},
Journal = {Psychosom Med},
Volume = {71},
Number = {6},
Pages = {642-645},
Year = {2009},
Month = {July},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19553288},
Abstract = {OBJECTIVE: To examine whether the relationship of hostility
(HOST) to fasting glucose indices is moderated by sex and
race. HOST has been associated with abnormalities in glucose
metabolism. Prior studies suggested that this association
may be more prevalent in women and in African American (AA)
individuals. METHODS: A total of 565 healthy AA and white
(W) men and women (mean age = 33 +/- 6 years) were assessed.
HOST was measured by the 27-item version of the Cook Medley
HOST Scale. The moderating effects of sex and race were
evaluated for the associations of HOST to fasting glucose,
insulin, and insulin sensitivity (HOMA-IR). RESULTS:
Analysis showed a moderating effect of sex and race on the
association of HOST to fasting glucose (p = .03), but not
for insulin (p = .12). Analysis of HOMA-IR revealed a trend
(p = .06) for the interaction. Stratified analyses by race
and sex revealed a positive association between HOST and
fasting glucose only in AA women, which remained significant
after controlling for age and body mass index. CONCLUSION: A
relationship between HOST and fasting glucose was evident in
AA women only, a group that has twice the risk of developing
Type 2 diabetes compared with W women. Further studies are
needed to elucidate the mechanisms by which HOST may affect
glucose metabolism in AA women.},
Doi = {10.1097/PSY.0b013e3181acee3a},
Key = {fds276174}
}
@article{fds276175,
Author = {Brummett, BH and Boyle, SH and Kuhn, CM and Siegler, IC and Williams,
RB},
Title = {Positive affect is associated with cardiovascular
reactivity, norepinephrine level, and morning rise in
salivary cortisol.},
Journal = {Psychophysiology},
Volume = {46},
Number = {4},
Pages = {862-869},
Year = {2009},
Month = {July},
ISSN = {0048-5772},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19470128},
Abstract = {Positive affect was examined as a predictor of (1)
cardiovascular reactivity during a sadness and an anger
recall task and recovery following the protocol, (2)
epinephrine (EPI) and norepinephrine (NOREPI) reactivity and
level during the recall protocol, and (3) the diurnal
pattern of salivary cortisol. Sample was 328 individuals.
Negative affect, age, race, sex, smoking status, income, and
BMI were adjusted. During sadness recall, positive affect
was inversely related to systolic blood pressure (p=.007)
and diastolic blood pressure (p=.049) reactivity, and
unrelated to heart rate (p=.226). Positive affect was
unrelated to reactivity during anger recall (ps>.19), and
was unrelated to recovery at the end of the recall protocol.
Positive affect was inversely related to the mean level of
NOREPI (p=.046), and unrelated to EPI (p=.149). Positive
affect was inversely related to the increase in cortisol 30
min post awakening (p=.042), and unrelated to the evening
decline in cortisol levels (p=.174). Positive emotions may
be relevant to good health.},
Doi = {10.1111/j.1469-8986.2009.00829.x},
Key = {fds276175}
}
@article{fds276227,
Author = {Brummett, BH and Boyle, SH and Siegler, IC and Kuhn, CM and Surwit, RS and Garrett, ME and Collins, A and Ashley-Koch, A and Williams,
RB},
Title = {HPA axis function in male caregivers: effect of the
monoamine oxidase-A gene promoter (MAOA-uVNTR).},
Journal = {Biol Psychol},
Volume = {79},
Number = {2},
Pages = {250-255},
Year = {2008},
Month = {October},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18639608},
Abstract = {Caregiving stress is associated with negative health
outcomes. Neuroendocrine functioning may be a mediator of
such outcomes. The MAOA gene regulates activity of
neurotransmitters involved with neuroendocrine responses to
stress. Differences in polymorphisms of this gene have been
shown to influence susceptibility to stress. Therefore, we
examined allelic variation in MAOA-uVNTR, a functional
polymorphism of MAOA, as a moderator of chronic stress
effects on urinary cortisol excretion in 74 males enrolled
in a case/control study of caregivers for relatives with
dementia. Mixed models analysis of variance were used to
examine MAOA-uVNTR genotype (3 repeats vs. 3.5/4 repeats) as
a moderator of the impact of stress (caregiver vs.
non-caregiver) on the urinary excretion pattern (overnight,
daytime, evening) of cortisol. Caregivers with MAOA-uVNTR
alleles associated with less transcriptional activity
(3-repeats) displayed a pattern of cortisol excretion -- a
decrease from overnight to daytime -- that was suggestive of
HPA axis blunting, as compared to non-caregivers and those
caregivers with the more active alleles (3.5/4 repeats)
(cortisol p<.043). Individuals with less active MAOA-uVNTR
alleles who are under chronic stress may be at increased
risk for exhaustion of the HPA response to such
stress.},
Doi = {10.1016/j.biopsycho.2008.06.004},
Key = {fds276227}
}
@article{fds276228,
Author = {Brummett, BH and Muller, CL and Collins, AL and Boyle, SH and Kuhn, CM and Siegler, IC and Williams, RB and Ashley-Koch, A},
Title = {5-HTTLPR and gender moderate changes in negative affect
responses to tryptophan infusion.},
Journal = {Behav Genet},
Volume = {38},
Number = {5},
Pages = {476-483},
Year = {2008},
Month = {September},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18661222},
Abstract = {Expression of the serotonin transporter is affected by the
genotype of the 5-HTTLPR (short and long forms) as well as
the genotype of the SNP rs25531 within this region. Based on
the combined genotypes for these polymorphisms, we
designated each allele as a high or low expressing allele
according to established expression levels-resulting in
HiHi, HiLo, & LoLo genotype groups for analysis. We
evaluated effects of gender and the promoter genotype on
induction of negative affect by intravenous infusion of L:
-tryptophan (TRP). The protocol consisted of a day-1 sham
saline infusion and a day-2 active TRP infusion. Models
assessed 5-HTTLPR composite genotype and gender as
predictors of change in ratings of negative emotion during
TRP infusion. During sham infusion there were no significant
changes from baseline in mood ratings. During TRP infusion
all negative affect ratings increased significantly from
baseline (P's < .02). The genotype x gender interaction was
a significant predictor of depression-dejection (P = .013),
and trended towards predicting anger-hostility (P = .084).
Males in the HiHi group had greater increases in negative
affect during infusion, compared to all groups except LoLo
females, who also showed increased negative
affect.},
Doi = {10.1007/s10519-008-9219-y},
Key = {fds276228}
}
@article{fds276172,
Author = {Brummett, BH and Boyle, SH and Kuhn, CM and Siegler, IC and Williams,
RB},
Title = {Associations among central nervous system serotonergic
function and neuroticism are moderated by
gender.},
Journal = {Biological Psychology},
Volume = {78},
Number = {2},
Pages = {200-203},
Year = {2008},
Month = {May},
ISSN = {0301-0511},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18417268},
Abstract = {Serotonergic dysregulation is associated with negative
affect. Plasma prolactin responses to a tryptophan
enhancement challenge are used as a measure of central
nervous system serotonergic activity. We examined prolactin
responses to a tryptophan challenge as they relate to the
personality domains of neuroticism, extraversion, openness,
agreeableness, and conscientiousness. Participants were 67
volunteers. Regression models assessed peak prolactin
response to intravenous tryptophan infusion as a predictor
of neuroticism, extraversion, openness, agreeableness, and
conscientiousness. Prolactinxgender product terms were
included to examine moderation by gender. Models were
adjusted for baseline levels of prolactin, age, and race.
Gender moderated the association between N and prolactin
level (p<.03). Higher levels of N were associated with
decreased levels of prolactin responses in females, whereas
the opposite was true for males. Remaining personality
domains were not related to prolactin levels. Findings add
to literature suggesting the serotonin system functions
differently, in important ways, in males and
females.},
Doi = {10.1016/j.biopsycho.2008.03.002},
Key = {fds276172}
}
@article{fds276226,
Author = {Brummett, BH and Boyle, SH and Siegler, IC and Zuchner, S and Ashley-Koch, A and Williams, RB},
Title = {Lipid levels are associated with a regulatory polymorphism
of the monoamine oxidase-A gene promoter
(MAOA-uVNTR).},
Journal = {Medical Science Monitor : International Medical Journal of
Experimental and Clinical Research},
Volume = {14},
Number = {2},
Pages = {CR57-CR61},
Year = {2008},
Month = {February},
ISSN = {1234-1010},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18227761},
Abstract = {BACKGROUND: The monoamine oxidase-A (MAOA) gene plays a
vital role in the metabolism of neurotransmitters, e.g,
serotonin, norepinephrine, and dopamine. A polymorphism in
the promoter region (MAOA-uVNTR) affects transcriptional
efficiency. Allelic variation in MAOA-uVNTR has been
associated with body mass index (BMI). We extended previous
work by examining relations among this polymorphism and
serum lipid levels. MATERIAL/METHODS: The sample consisted
of 74 males enrolled in a study of caregivers for relatives
with dementia. Regression models, adjusted for age, race,
group status (caregiver/control), and cholesterol lowering
medication (yes/no), were used to examine associations
between high verses low MAOA-uVNTR activity alleles and
total cholesterol, HDL, LDL, VLDL, LDL/HDL ratio,
triglycerides, and BMI. RESULTS: Higher total cholesterol
(p<0.03), LDL/HDL ratio (p<0.01), triglycerides (p<0.02),
and VLDL (p<0.02) were associated with low activity
MAOA-uVNTR alleles. HDL and LDL were modestly related to
MAOA-uVNTR activity, however, they did not reach the
conventional significance level (p<0.07 and p<0.10,
respectively). BMI (p<0.74) was unrelated to MAOA-uVNTR
transcription. CONCLUSIONS: The present findings suggest
that MAOA-uVNTR may influence lipid levels and individuals
with less active alleles are at increased health
risk.},
Key = {fds276226}
}
@article{fds276224,
Author = {Williams, RB and Marchuk, DA and Siegler, IC and Barefoot, JC and Helms,
MJ and Brummett, BH and Surwit, RS and Lane, JD and Kuhn, CM and Gadde, KM and Ashley-Koch, A and Svenson, IK and Suarez, EC and Schanberg,
SM},
Title = {Childhood socioeconomic status and serotonin transporter
gene polymorphism enhance cardiovascular reactivity to
mental stress.},
Journal = {Psychosom Med},
Volume = {70},
Number = {1},
Pages = {32-39},
Year = {2008},
Month = {January},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18158371},
Abstract = {OBJECTIVE: To test the hypothesis that low socioeconomic
status (SES) and the 5HTTLPR L allele are associated with
increased cardiovascular reactivity (CVR) to stress in a
larger sample and that SES and 5HTTLPR genotypes interact to
enhance CVR to stress. CVR to mental stress has been
proposed as one mechanism linking stress to the pathogenesis
of cardiovascular disease. The more transcriptionally
efficient long (L) allele of a polymorphism of the serotonin
transporter gene promoter (5HTTLPR) has been found
associated with increased risk of myocardial infarction. We
found the long allele associated with larger CVR to mental
stress in a preliminary study of 54 normal volunteers.
METHODS: Subjects included 165 normal community volunteers
stratified for race, gender, and SES, who underwent mental
stress testing. RESULTS: Childhood SES as indexed by
Father's Education Level was associated with larger systolic
blood pressure (SBP) (p < .05) and diastolic blood pressure
(DBP) (p = .01) responses to mental stress. The L allele was
associated with larger SBP (p = .04), DBP (p < .0001), and
heart rate (p = .04) responses to mental stress compared
with the short (S) allele. Subjects with the SS genotype and
high Father's Education exhibited smaller SBP (5.2 mm Hg)
and DBP (2.9 mm Hg) responses than subjects with LL genotype
and low Father's Education (SBP = 13.3 mm Hg, p = .002; DBP
= 9.7 mm Hg, p < .0001). CONCLUSIONS: Both the 5HTTLPR long
allele and low SES, particularly during childhood, are
associated with increased CVR to mental stress, which could
account, at least in part, for the increased cardiovascular
disease risk associated with these characteristics. If
confirmed in further research, these characteristics could
be used to identify persons who might benefit from
preventive interventions.},
Doi = {10.1097/PSY.0b013e31815f66c3},
Key = {fds276224}
}
@article{fds276225,
Author = {Brummett, BH and Boyle, SH and Siegler, IC and Kuhn, CM and Ashley-Koch,
A and Jonassaint, CR and Züchner, S and Collins, A and Williams,
RB},
Title = {Effects of environmental stress and gender on associations
among symptoms of depression and the serotonin transporter
gene linked polymorphic region (5-HTTLPR).},
Journal = {Behavior Genetics},
Volume = {38},
Number = {1},
Pages = {34-43},
Year = {2008},
Month = {January},
ISSN = {0001-8244},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17955359},
Abstract = {The short (s) variant of the serotonin transporter (5-HTT)
gene linked functional polymorphic region (5-HTTLPR) is
associated with depression. Stressful life events, gender,
and race have been shown to moderate this association. We
examined the relationship between 5-HTTLPR genotype and
symptoms of depression in two samples. Study 1 = 288
participants from a study of caregiver stress; and Study 2 =
142 participants from a study examining psychosocial
stressors, genetics, and health. Main effects of 5-HTTLPR on
symptoms of depression were examined, along with moderation
by stress (caregiving status or low childhood socioeconomic
status (SES), gender, and race. The 5-HTTLPR x stress group
x gender interaction was significant in both samples (P <
0.003, and P < 0.008, respectively). For females, the s
allele, combined with caregiving stress (Study 1) or low
childhood SES (Study 2), was associated with higher
depression scores as compared to participants in the
non-stressor group and those with the long (l) allele;
whereas, in males, the l allele, combined with a stressor,
was associated with higher depression scores as compared to
those in the non-stressor group and those with the s allele.
Findings from two independent samples suggest that the
association of 5-HTTLPR with depression varies according to
gender and stressful life events.},
Doi = {10.1007/s10519-007-9172-1},
Key = {fds276225}
}
@article{fds276171,
Author = {Brummett, BH and Siegler, IC and Day, RS and Costa,
PT},
Title = {Personality as a predictor of dietary quality in spouses
during midlife.},
Journal = {Behavioral Medicine (Washington, D.C.)},
Volume = {34},
Number = {1},
Pages = {5-10},
Year = {2008},
ISSN = {0896-4289},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18400684},
Abstract = {The authors evaluated the NEO Personality Inventory-Revised
(NEO-PI-R) as a predictor of dietary quality in 850 married
couples, focusing on associations among each participant's
personality as a predictor of their own dietary quality and
their spouses' dietary quality. Diet was based on a modified
version of the US Department of Agriculture Healthy Eating
Index. Openness was associated with self-ratings of dietary
quality for wives (r = .28) and husbands (r = .27). Wives'
levels of the characteristic openness were also related to
their spouses' ratings of dietary quality (r = .22). The
primary facets of openness accounting for the domain-level
findings were O2-aesthetics and O4-actions. The remaining
personality domains (neuroticism, extraversion,
agreeableness, and conscientiousness) were not associated
with self or spousal ratings of dietary quality (rs =
.08-.09). Openness was associated with healthy eating
habits--findings that may affect disease prevention during,
midlife.},
Doi = {10.3200/BMED.34.1.5-10},
Key = {fds276171}
}
@article{fds276205,
Author = {Richman, LS and Bennett, GG and Pek, J and Siegler, I and Williams,
RB},
Title = {Discrimination, dispositions, and cardiovascular responses
to stress.},
Journal = {Health Psychology : Official Journal of the Division of
Health Psychology, American Psychological
Association},
Volume = {26},
Number = {6},
Pages = {675-683},
Year = {2007},
Month = {November},
ISSN = {0278-6133},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18020838},
Abstract = {OBJECTIVE: Recent research suggests that past exposure to
discrimination may influence perceptions of, and
physiological responses to, new challenges. The authors
examined how race and trait levels of hostility and optimism
interact with past exposure to discrimination to predict
physiological reactivity and recovery during an anger recall
task. DESIGN: A community sample of 165 normotensive Black
and White adults participated in an anger recall task while
having their cardiovascular function monitored. MAIN OUTCOME
MEASURES: Blood pressure and heart rate indicators of
physiological reactivity and recovery. RESULTS AND
CONCLUSION: Participants had higher reactivity and slower
recovery to the anger recall task when they had high past
discrimination, low cynicism, or high optimism. The pattern
of effects was similar for both racial groups, but Blacks
had more acute reactivity and slower recovery than Whites.
These results are consistent with the perspective of
discrimination as a chronic stressor that is related to
acute stress responses, particularly for
Blacks.},
Doi = {10.1037/0278-6133.26.6.675},
Key = {fds276205}
}
@article{fds276222,
Author = {Brummett, BH and Krystal, AD and Siegler, IC and Kuhn, C and Surwit, RS and Züchner, S and Ashley-Koch, A and Barefoot, JC and Williams,
RB},
Title = {Associations of a regulatory polymorphism of monoamine
oxidase-A gene promoter (MAOA-uVNTR) with symptoms of
depression and sleep quality.},
Journal = {Psychosom Med},
Volume = {69},
Number = {5},
Pages = {396-401},
Year = {2007},
Month = {June},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17585061},
Abstract = {OBJECTIVE: To examine the relationships among the variable
number of tandem repeats in the monoamine oxidase-A linked
polymorphic region allelic variation (MAOA-uVNTR) and the
symptoms of depression and sleep quality. The monoamine
oxidase-A (MAOA) gene, which plays a vital role in
degradation of neurotransmitters such as serotonin,
norepinephrine, and dopamine, contains a polymorphism in its
promoter region (MAOA-uVNTR) that affects transcriptional
efficiency. MAOA-uVNTR genotype has been associated with
both psychological and physical measures. METHODS: The
sample consisted of 74 males enrolled in a case/control
study of caregivers for relatives with dementia. Age- and
race-adjusted linear regression models were used to examine
the association between low versus high MAOA-uVNTR activity
alleles, symptoms of depression (Center for Epidemiological
Studies of Depression), and sleep quality ratings
(Pittsburgh Sleep Quality Index). RESULTS: MAOA-uVNTR
alleles associated with less transcriptional activity were
related to increased symptoms of depression (p < .04;
Cohen's d = 0.52) and poorer sleep quality (p < .04; Cohen's
d = 0.31). CONCLUSIONS: Individuals with less active
MAOA-uVNTR alleles may be at increased risk for depressive
symptoms and poor sleep.},
Doi = {10.1097/PSY.0b013e31806d040b},
Key = {fds276222}
}
@article{fds276141,
Author = {Jonassaint, CR and Boyle, SH and Williams, RB and Mark, DB and Siegler,
IC and Barefoot, JC},
Title = {Facets of openness predict mortality in patients with
cardiac disease.},
Journal = {Psychosom Med},
Volume = {69},
Number = {4},
Pages = {319-322},
Year = {2007},
Month = {May},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17510289},
Abstract = {OBJECTIVE: To examine the NEO Personality Inventory (NEO PI)
Openness to Experience (O) domain and its facets as
predictors of cardiac deaths and all-cause mortality.
METHODS: The NEO PI was administered to a sample of 977
coronary catheterization patients with significant coronary
artery disease. Over an average 15-year follow-up period,
266 cardiac deaths and 463 total deaths occurred. The
relationships of O scores to mortality were examined with
Cox proportional hazard models. Each model included age,
left ventricular ejection fraction, severity of congestive
heart failure, and number of diseased vessels as covariates.
RESULTS: The O domain score was not associated with
all-cause mortality and only approached significance for
decreased cardiac deaths (p = .055). However, a higher score
for Openness to Feelings was associated with a decreased
risk of cardiac death (p < .01) and all-cause mortality (p <
.01). High Openness to Actions was also associated with
decreased cardiac mortality (p < .01) and all-cause
mortality (p = .03) risk. Higher Openness to Aesthetics and
Ideas were only associated with decreased cardiac death risk
(both p values <.04). In contrast, Openness to Fantasy and
Values were not associated with longevity. Previous evidence
suggested that educational achievement may account for the
effects of Openness to Experience on mortality; however,
controlling for educational achievement did not change the
results. CONCLUSION: These findings suggest that greater
emotional awareness and high curiosity, as indicated by the
NEO PI Feelings and Actions facets, are associated with
increased patient longevity independently of other risk
factors and educational achievement.},
Doi = {10.1097/PSY.0b013e318052e27d},
Key = {fds276141}
}
@article{fds276223,
Author = {Brummett, BH and Krystal, AD and Ashley-Koch, A and Kuhn, CM and Züchner, S and Siegler, IC and Barefoot, JC and Ballard, EL and Gwyther, LP and Williams, RB},
Title = {Sleep quality varies as a function of 5-HTTLPR genotype and
stress.},
Journal = {Psychosom Med},
Volume = {69},
Number = {7},
Pages = {621-624},
Year = {2007},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17766685},
Abstract = {OBJECTIVE: To test the hypothesis that allelic variation in
5HTT gene-linked polymorphic region (5-HTTLPR) genotype was
associated with sleep quality (Pittsburgh Sleep Quality
Index, PSQI) as a main effect and as moderated by the
chronic stress of caregiving. Serotonin (5HT) is involved in
sleep regulation and the 5HT transporter (5HTT) regulates
5HT function. A common 44-base pair deletion (s allele)
polymorphism in the 5-HTTLPR is associated with reduced 5HTT
transcription efficiency and 5HT uptake in vitro. METHODS:
Subjects were 142 adult primary caregivers for a spouse or
parent with dementia and 146 noncaregiver controls. Subjects
underwent genotyping and completed the PSQI. RESULTS:
Variation in 5-HTTLPR genotype was not related to sleep
quality as a main effect (p > .36). However, there was a
caregiver X 5-HTTLPR interaction (p < .009), such that the s
allele was associated with poorer sleep quality in
caregivers as compared with controls. CONCLUSIONS: Findings
suggest that the s allele may moderate sleep disturbance in
response to chronic stress.},
Doi = {10.1097/PSY.0b013e31814b8de6},
Key = {fds276223}
}
@article{fds276123,
Author = {Johnson, MA and Davey, A and Hausman, DB and Park, S and Poon, LW and Jazwinski, SM and Green, RC and Gearing, M and Markesbery, WR and Woodard, JL and Tenover, JS and Siegler, IC and Martin, P and MacDonald,
M and Rott, C and Rodgers, WL and Arnold, J},
Title = {Dietary differences between centenarians residing in
communities and in skilled nursing facilities: The Georgia
centenarian study},
Journal = {Age (Dordrecht, Netherlands)},
Volume = {28},
Number = {4},
Pages = {333-341},
Publisher = {Springer Nature},
Year = {2006},
Month = {December},
ISSN = {0161-9152},
url = {http://dx.doi.org/10.1007/s11357-006-9021-9},
Abstract = {The purpose of this study was to examine the dietary habits
among centenarians residing in community settings (n=105)
and in skilled nursing facilities (n=139). The sample was a
population-based multi-ethnic sample of adults aged 98 years
and older (N=244) from northern Georgia in the US. Compared
to centenarians in skilled nursing facilities, those
residing in the community were more than twice as likely to
be able to eat without help and to receive most of their
nourishment from typical foods, but they had a lower
frequency of intake of all of the food groups examined,
including dairy, meat, poultry and fish, eggs, green
vegetables, orange/yellow vegetables, citrus fruit or juice,
non-citrus fruit or juice, and oral liquid supplements. A
food summary score was created (the sum of the meeting
recommendations for five food groups). In multiple
regression analyses, the food summary scores were positively
associated with residing in a nursing facility and
negatively associated with eating without help and receiving
most nourishment from typical foods. These data suggest that
centenarians residing in communities may have limited access
to foods that are known to provide nutrients essential to
health and well-being. Also, centenarians who are able to
eat without help and/or who eat mainly typical foods may
have inadequate intakes of recommended food groups. Given
the essential role of foods and nutrition to health and
well-being throughout life, these findings require further
exploration through the detailed dietary analyses of
centenarians living in various settings. © 2006 American
Aging Association.},
Doi = {10.1007/s11357-006-9021-9},
Key = {fds276123}
}
@article{fds276124,
Author = {Martin, P and da Rosa, G and Siegler, IC and Davey, A and Macdonald, M and Poon, LW and Georgia Centenarian Study},
Title = {Personality and longevity: findings from the Georgia
Centenarian Study.},
Journal = {Age (Dordrecht, Netherlands)},
Volume = {28},
Number = {4},
Pages = {343-352},
Year = {2006},
Month = {December},
ISSN = {0161-9152},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22253500},
Abstract = {Centenarians are thought of as unique and exceptional
survivors. This study evaluated specific personality traits
and configurations of traits among participants of the
Georgia Centenarian Study. Two hundred and eighty five
centenarians and their nominated proxies participated in
this study. Self ratings and proxy informant ratings were
obtained for different traits and facets of the Big-5
personality typology. Results suggested that centenarians
overall had low levels of Neuroticism, but high levels of
Extraversion, Competence, and Trust. When compared to
centenarian self ratings, proxies provided significantly
higher ratings for Neuroticism, Hostility, and
Vulnerability, but lower ratings for Competence and Trust.
Among Centenarians, the personality configuration of low
Neuroticism, high Competence, and high Extraversion traits
is over-represented relative to chance. The results confirm
that centenarians show several unique single traits, but
that a special combination of traits (i.e., low levels of
Neuroticism, high Competence, and high Extraversion) are
also notable in this group of exceptional
survivors.},
Doi = {10.1007/s11357-006-9022-8},
Key = {fds276124}
}
@article{fds276170,
Author = {Brummett, BH and Helms, MJ and Dahlstrom, WG and Siegler,
IC},
Title = {Prediction of all-cause mortality by the Minnesota
Multiphasic Personality Inventory Optimism-Pessimism Scale
scores: study of a college sample during a 40-year follow-up
period.},
Journal = {Mayo Clinic Proceedings},
Volume = {81},
Number = {12},
Pages = {1541-1544},
Year = {2006},
Month = {December},
ISSN = {0025-6196},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17165632},
Abstract = {OBJECTIVE: To examine a measure of explanatory style, the
Optimism-Pessimism (PSM) scale derived from college-entry
Minnesota Multiphasic Personality Inventory scores, as a
predictor of all-cause mortality. SUBJECTS AND METHODS: A
total of 7007 students entering the University of North
Carolina at Chapel Hill completed the Minnesota Multiphasic
Personality Inventory during the mid-1960s. Of those
students, 6958 had scores on the PSM scale and data for
all-cause mortality through 2006. Scores on the PSM scale
were evaluated as predictors of mortality using the Cox
proportional hazards regression model, adjusted for sex.
During the 40-year follow-up period, 476 deaths occurred.
RESULTS: Pessimistic individuals who scored in the upper
tertile of the distribution had decreased rates of longevity
(hazard ratio, 1.42; 95% confidence Interval, 1.13-1.77)
compared with optimistic individuals who scored in the
bottom tertile of the distribution. CONCLUSION: In a model
that adjusted only for sex, a measure of optimistic vs
pessimistic explanatory style was a significant predictor of
survival during a 40-year follow-up period such that
optimists had Increased longevity.},
Doi = {10.4065/81.12.1541},
Key = {fds276170}
}
@article{fds276122,
Author = {Mortensen, LH and Siegler, IC and Barefoot, JC and Grønbaek, M and Sørensen, TIA},
Title = {Prospective associations between sedentary lifestyle and BMI
in midlife.},
Journal = {Obesity (Silver Spring, Md.)},
Volume = {14},
Number = {8},
Pages = {1462-1471},
Year = {2006},
Month = {August},
ISSN = {1930-7381},
url = {http://www.ncbi.nlm.nih.gov/pubmed/16988090},
Abstract = {OBJECTIVE: A strong positive cross-sectional relationship
between BMI and a sedentary lifestyle has been consistently
observed in numerous studies. However, it has been
questioned whether high BMI is a determinant or a
consequence of a sedentary lifestyle. RESEARCH METHODS AND
PROCEDURES: Using data from four follow-ups of the
University of North Carolina Alumni Heart Study, we examined
the prospective associations between BMI and sedentary
lifestyle in a cohort of 4595 middle-aged men and women who
had responded to questionnaires at the ages of 41 (standard
deviation 2.3), 44 (2.3), 46 (2.0), and 54 (2.0). RESULTS:
BMI was consistently related to increased risk of becoming
sedentary in both men and women. The odds ratios of becoming
sedentary as predicted by BMI were 1.04 (95% confidence
limits, 1.00, 1.07) per 1 kg/m(2) from ages 41 to 44, 1.10
(1.07, 1.14) from ages 44 to 46, and 1.12 (1.08, 1.17) from
ages 46 to 54. Controlling for concurrent changes in BMI
marginally attenuated the effects. Sedentary lifestyle did
not predict changes in BMI, except when concurrent changes
in physical activity were taken into account (p < 0.001).
The findings were not confounded by preceding changes in BMI
or physical activity, age, smoking habits, or sex.
DISCUSSION: Our findings suggest that a high BMI is a
determinant of a sedentary lifestyle but did not provide
unambiguous evidence for an effect of sedentary lifestyle on
weight gain.},
Doi = {10.1038/oby.2006.166},
Key = {fds276122}
}
@article{fds276217,
Author = {Brummett, BH and Babyak, MA and Williams, RB and Barefoot, JC and Costa,
PT and Siegler, IC},
Title = {NEO personality domains and gender predict levels and trends
in body mass index over 14 years during midlife},
Journal = {Journal of Research in Personality},
Volume = {40},
Number = {3},
Pages = {222-236},
Publisher = {Elsevier BV},
Year = {2006},
Month = {June},
ISSN = {0092-6566},
url = {http://dx.doi.org/10.1016/j.jrp.2004.12.002},
Abstract = {Mixed models were used to examine NEO-PI scores as
predictors of body mass index (BMI) over a 14 year period
during midlife. Average BMI levels during midlife were
positively related to Neuroticism and negatively related to
Openness, Agreeableness, and Conscientiousness. Relations
for three domains were modified by gender. Neuroticism was
significantly related to BMI in females only. Extraversion
was positively related to BMI in males, whereas, this
relation was non-significant in females. The relation
between Conscientiousness and BMI was significant in males
and females, however, the magnitude of the negative
association was stronger in females. Conscientiousness also
predicted change in BMI during midlife such that
participants who were lower in Conscientiousness tended to
show larger gains in BMI with age. © 2005 Elsevier Inc. All
rights reserved.},
Doi = {10.1016/j.jrp.2004.12.002},
Key = {fds276217}
}
@article{fds276216,
Author = {Brummett, BH and Babyak, MA and Siegler, IC and Vitaliano, PP and Ballard, EL and Gwyther, LP and Williams, RB},
Title = {Associations among perceptions of social support, negative
affect, and quality of sleep in caregivers and
noncaregivers.},
Journal = {Health Psychology : Official Journal of the Division of
Health Psychology, American Psychological
Association},
Volume = {25},
Number = {2},
Pages = {220-225},
Year = {2006},
Month = {March},
ISSN = {0278-6133},
url = {http://www.ncbi.nlm.nih.gov/pubmed/16569114},
Abstract = {The authors used structural equation modeling to examine
associations among perceptions of negative affect, social
support, and quality of sleep in a sample of caregivers (n =
175) and noncaregiver control participants (n = 169). The
authors hypothesized that caregiver status would be related
to sleep quality directly and also indirectly by way of
negative affect and social support. This hypothesis was
partially supported in that caregiving was found to be
indirectly related to sleep quality. However, after
accounting for the indirect effects of negative affect and
social support, the direct effect of caregiving on sleep
quality was no longer statistically significant. The
structural model accounted for approximately 43% of the
variance in sleep quality. The present findings may be
useful in the development of successful sleep interventions
for caregivers.},
Doi = {10.1037/0278-6133.25.2.220},
Key = {fds276216}
}
@article{fds276121,
Author = {Vitaliano, PP and Echeverria, D and Yi, J and Phillips, PEM and Young,
H and Siegler, IC},
Title = {Psychophysiological mediators of caregiver stress and
differential cognitive decline.},
Journal = {Psychology and Aging},
Volume = {20},
Number = {3},
Pages = {402-411},
Year = {2005},
Month = {September},
ISSN = {0882-7974},
url = {http://www.ncbi.nlm.nih.gov/pubmed/16248700},
Abstract = {The authors examined relationships between chronic stress
and cognitive decline and whether such relationships were
mediated by psychophysiological factors. Ninety-six
caregivers of spouses with Alzheimer's disease (AD) were
compared with 95 similar noncaregiver spouses. All were free
of diabetes. Although the groups started similarly, over 2
years caregivers declined by a small but significant amount
(1 raw score point and 4 percentile points, each p<.05) on
Shipley Vocabulary. In contrast, noncaregivers did not
change. Higher hostile attribution (beta=-.09; p<.05) and
metabolic risk (beta=-.10; p<.05) in caregivers mediated the
cognitive decline. This is the first study of cognitive
decline and mediators in caregivers. This work has
implications for caregiver and care-recipient health and for
research on cognition, psychophysiology, diabetes, and
AD.},
Doi = {10.1037/0882-7974.20.3.402},
Key = {fds276121}
}
@article{fds276168,
Author = {Dilworth-Anderson, P and Brummett, BH and Goodwin, P and Williams,
SW and Williams, RB and Siegler, IC},
Title = {Effect of race on cultural justifications for
caregiving.},
Journal = {The Journals of Gerontology. Series B, Psychological
Sciences and Social Sciences},
Volume = {60},
Number = {5},
Pages = {S257-S262},
Year = {2005},
Month = {September},
ISSN = {1079-5014},
url = {http://www.ncbi.nlm.nih.gov/pubmed/16131626},
Abstract = {OBJECTIVE: Our objective in this study was to explore the
effects of caregiver characteristics on cultural reasons
given for providing care to dependent elderly family
members. METHODS: The sample included 48 African American
and 121 White caregivers. Using multivariate analyses, we
used caregiver characteristics (e.g., race, gender,
education) to predict scores on the Cultural Justifications
for Caregiving Scale (CJCS). RESULTS: Confirmatory factor
analysis showed that the CJCS was appropriate for both
African American and White caregivers. African Americans had
stronger cultural reasons for providing care than Whites,
education levels were inversely related to CJCS scores, and
the influences of gender and age on cultural reasons were
moderated by race. Compared to females, African American
males had lower CJCS scores, whereas White males had higher
CJCS scores. Younger as compared to older White caregivers
had higher CJCS scores. DISCUSSION: This study supports the
long-standing cultural tradition of African American
families providing care to dependent elders. Cultural
reasons for caregiving need to be interpreted within the
context of race and gender socialization. Social roles, such
as husband or wife, son or daughter, can also help determine
how individuals within a particular cultural group
experience cultural expectations and obligations.
Information from this study can inform culturally
appropriate caregiving interventions.},
Doi = {10.1093/geronb/60.5.s257},
Key = {fds276168}
}
@article{fds276167,
Author = {Boyle, SH and Williams, RB and Mark, DB and Brummett, BH and Siegler,
IC and Barefoot, JC},
Title = {Hostility, age, and mortality in a sample of cardiac
patients.},
Journal = {The American Journal of Cardiology},
Volume = {96},
Number = {1},
Pages = {64-66},
Year = {2005},
Month = {July},
ISSN = {0002-9149},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15979435},
Abstract = {This study examined hostility as a predictor of survival in
a sample of 1,328 patients who had documented coronary
artery disease. After controlling for disease severity,
there was a significant interaction between age and
hostility. Hostility was significantly associated with
poorer survival but only in younger (<61.2 years)
patients.},
Doi = {10.1016/j.amjcard.2005.02.046},
Key = {fds276167}
}
@article{fds276166,
Author = {Brummett, BH and Boyle, SH and Siegler, IC and Williams, RB and Mark,
DB and Barefoot, JC},
Title = {Ratings of positive and depressive emotion as predictors of
mortality in coronary patients.},
Journal = {International Journal of Cardiology},
Volume = {100},
Number = {2},
Pages = {213-216},
Year = {2005},
Month = {April},
ISSN = {0167-5273},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15823627},
Abstract = {BACKGROUND: An extensive body of research has demonstrated
an association between negative affective states and health
outcomes. Positive emotions may also influence physical
health, however, their examination has received far less
attention. METHODS: Positive and depressive emotion ratings
were examined as independent and joint predictors of
survival in a sample of 866 cardiac catheterization
patients. The mean follow-up was 11.4 years, during which
415 deaths occurred. The mean age of the sample was 60.3
years and 74.3% of the sample were males. RESULTS: Both
positive and depressive ratings were associated with
survival (hazard ratio=0.80, 95% CI=0.66-0.97, p<0.025 and
hazard ratio=1.32, 95% CI=1.13-1.54, p<0.001, respectively),
adjusted for risk factors. Positive emotion ratings were no
longer significantly related to mortality when the two
emotion measures were simultaneously included in a survival
model. CONCLUSION: The current findings are consistent with
a theory that suggests that the relation between positive
emotion and mortality may be partly mediated by depressive
emotion.},
Doi = {10.1016/j.ijcard.2004.06.016},
Key = {fds276166}
}
@article{fds276198,
Author = {Bosworth, HB and Bastian, LA and Grambow, SC and McBride, CM and Skinner, CS and Fish, L and Rimer, BK and Siegler,
IC},
Title = {Initiation and discontinuation of hormone therapy for
menopausal symptoms: results from a community
sample.},
Journal = {Journal of Behavioral Medicine},
Volume = {28},
Number = {1},
Pages = {105-114},
Year = {2005},
Month = {February},
ISSN = {0160-7715},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15887880},
Abstract = {Factors related to initiation and discontinuation of
hormonal therapy (HT) for treatment of menopausal symptoms
were examined in a community sample of 533
peri/postmenopausal women aged 45-54 by telephone three
times. Over 40 variables including: sociodemographic
characteristics, clinical reasons to start HT use, HT
contraindications, HT attitudes/knowledge, and health
behaviors were examined in logistic regression models
comparing women who discontinued HT to women who continued
using HT over 9 months (discontinuers) and women who
initiated HT versus women who never used HT over 9 months
(initiators). Increased understanding of HT, confidence,
mental health symptoms, perception that menopause is
natural, and having gynecological surgery were related to
decreased likelihood of HT discontinuation. Increased
understanding about risks of HT, vasomotor symptoms, mood
symptoms, and having gynecological surgery were related to
increased likelihood of HT Initiation. These findings
highlight the importance of physicians discussing HT with
their patients, particularly because of recent clinical
trial developments.},
Doi = {10.1007/s10865-005-2721-2},
Key = {fds276198}
}
@article{fds276234,
Author = {Applegate, KL and Keefe, FJ and Siegler, IC and Bradley, LA and McKee,
DC and Cooper, KS and Riordan, P},
Title = {Does personality at college entry predict number of reported
pain conditions at mid-life? A longitudinal
study.},
Journal = {The Journal of Pain : Official Journal of the American Pain
Society},
Volume = {6},
Number = {2},
Pages = {92-97},
Year = {2005},
Month = {February},
ISSN = {1526-5900},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15694875},
Abstract = {UNLABELLED: The purpose of this study was to evaluate
whether personality traits, as assessed by the Minnesota
Multiphasic Personality Inventory (MMPI), at time of college
entry can predict the number of reported pain conditions at
an approximate 30-year follow-up for 2332 subjects, 1834 men
and 498 women, who were administered the MMPI on entry to
the University of North Carolina (Chapel Hill) between 1964
and 1966. In 1997, a follow-up was conducted in which
subjects were administered a self-report questionnaire
regarding whether they had experienced 1 or more chronic
pain conditions. Analyses of the relationship between the
MMPI clinical scales at college entrance and the report of
number of chronic pain conditions at follow-up were
conducted. Among male participants, elevations of Scales 1
(Hypochondriasis), 3 (Hysteria), and 5 (Masculinity/Femininity)
predicted increases in number of chronic pain conditions at
follow-up. For female participants, elevations in Scales 1,
3, and 6 (Paranoia) predicted increases in number of chronic
pain conditions at follow-up. The current study suggests
that a statistically significant relationship exists between
MMPI responses at college entry and reports of chronic pain
conditions at mid-life. PERSPECTIVE: This study found a
small, but significant relationship between elevations on
MMPI scales measuring hypochondriasis and hysteria and the
report of chronic pain conditions at follow-up. The study is
important because it is the first to examine how personality
assessed in younger adults relates to the number of chronic
pain conditions reported 30 years later.},
Doi = {10.1016/j.jpain.2004.11.001},
Key = {fds276234}
}
@article{fds276169,
Author = {Brummett, BH and Siegler, IC and Rohe, WM and Barefoot, JC and Vitaliano, PP and Surwit, RS and Feinglos, MN and Williams,
RB},
Title = {Neighborhood characteristics moderate effects of caregiving
on glucose functioning.},
Journal = {Psychosom Med},
Volume = {67},
Number = {5},
Pages = {752-758},
Year = {2005},
url = {http://www.ncbi.nlm.nih.gov/pubmed/16204434},
Abstract = {OBJECTIVE: Adverse neighborhood environments and caregiving
for a relative with dementia are both stressors that have
been associated with poor health. The present study examined
the extent to which three self-report measures of
neighborhood characteristics interact with caregiving status
(caregiver versus noncaregiver) to modify an important
stress related health outcome: plasma glucose. METHODS: The
study sample consisted of 147 community recruited caregivers
and 147 participants who did not have caregiving
responsibilities. We hypothesized that negative neighborhood
characteristics would magnify effects of caregiving on
plasma glucose levels. Regression analyses were conducted to
examine the interaction of three neighborhood characteristic
measures with caregiving status in predicting fasting plasma
glucose (FPG) and glycosylated hemoglobin concentration
(HbA1c), with control for age, race, gender, relation to
care recipient (spouse or relative), body mass index,
income, and education. RESULTS: Of the three neighborhood
measures, the one reflecting crime concerns significantly
moderated the effect of caregiving on FPG (p < .002) and
HbA1c (p < .001). For participants with better neighborhood
characteristics, caregivers and noncaregivers were similar
with respect to indicators of glucose metabolism; however,
for participants with worse neighborhood characteristics,
caregivers had higher levels of FPG and HbA1c, as compared
with noncaregivers. CONCLUSIONS: Poor health outcomes, such
as impaired glucose control, may be found among caregivers
who fear neighborhood crime.},
Doi = {10.1097/01.psy.0000174171.24930.11},
Key = {fds276169}
}
@article{fds276215,
Author = {Brummett, BH and Mark, DB and Siegler, IC and Williams, RB and Babyak,
MA and Clapp-Channing, NE and Barefoot, JC},
Title = {Perceived social support as a predictor of mortality in
coronary patients: effects of smoking, sedentary behavior,
and depressive symptoms.},
Journal = {Psychosom Med},
Volume = {67},
Number = {1},
Pages = {40-45},
Year = {2005},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15673622},
Abstract = {OBJECTIVE: Numerous studies have shown network assessments
of social contact predict mortality in patients with
coronary artery disease (CAD). Fewer studies have
demonstrated an association between perceived social support
and longevity in patient samples. It has been suggested that
1 of the mechanisms linking social support with elevated
risk for mortality is the association between social support
and other risk factors associated with decreased longevity
such as smoking, failure to exercise, and depressive
symptoms. The present study examined an assessment of
perceived support as a predictor of all-cause and CAD
mortality and examined the hypothesis that smoking,
sedentary behavior, and depressive symptoms may mediate
and/or moderate this association. METHODS: Ratings of social
support and the risk factors of smoking, sedentary behavior,
and depressive symptoms were examined as predictors of
survival in 2711 patients with CAD, and associations between
support and these risk factors were assessed. Smoking,
sedentary behavior, and depressive symptoms were examined as
mediators and/or moderators of the association between
social support and mortality. RESULTS: Social support,
smoking, sedentary behavior, and depressive symptoms were
predictors of mortality (p's <.01). Results also indicated
that sedentary behavior, but not smoking status or
depressive symptoms, may substantially mediate the
relationship between support and mortality. No evidence for
moderation was found. CONCLUSIONS: The relation between
social support and longevity may be partially accounted for
by the association between support and sedentary
behavior.},
Doi = {10.1097/01.psy.0000149257.74854.b7},
Key = {fds276215}
}
@article{fds276135,
Author = {Rubin, DC and Siegler, IC},
Title = {Facets of personality and the phenomenology of
autobiographical memory},
Volume = {18},
Number = {7},
Pages = {913-930},
Publisher = {WILEY},
Year = {2004},
Month = {November},
url = {http://hdl.handle.net/10161/10114 Duke open
access},
Abstract = {The relationship between individual differences in
autobiographical memory and personality was examined by
having 118 undergraduates complete the NEO Personality
Inventory after rating 15 word-cued autobiographical
memories on 20 scales. The Openness to Feelings facet (O3)
correlated with measures of belief in the accuracy of
memories, recollection, sensory imagery and emotion. Four
other facets had correlations with belief (A3 - Altruism, E1
- Warmth, E4 - Activity, E6 - Positive Emotions). These
facets also deal with emotional components of personality.
In multiple regressions, measures of belief and measures of
recollection were predicted by different variables, and for
measures of belief, the O3 facet increased the variance
accounted for beyond that of just the cognitive variables.
Our results are consistent with and extend studies of the
effects of depression and emotional suppression on
autobiographical memory. Copyright © 2004 John Wiley &
Sons, Ltd.},
Doi = {10.1002/acp.1038},
Key = {fds276135}
}
@article{fds276214,
Author = {Brummett, BH and Babyak, MA and Mark, DB and Clapp-Channing, NE and Siegler, IC and Barefoot, JC},
Title = {Prospective study of perceived stress in cardiac
patients.},
Journal = {Annals of Behavioral Medicine},
Volume = {27},
Number = {1},
Pages = {22-30},
Year = {2004},
Month = {February},
ISSN = {0883-6612},
url = {http://www.ncbi.nlm.nih.gov/pubmed/14979860},
Abstract = {BACKGROUND: Psychological stress is known to have a negative
effect on the health and well-being of coronary artery
disease (CAD) patients. Although the study of stress CAD
samples has received considerable attention, few studies
have examined the effects of gender and age, had multiple
follow-ups over an extended period, and had extensive
baseline assessment batteries. PURPOSE: In this study,
demographic, clinical, social, and personality variables
were evaluated as predictors of nine repeated assessments of
stress over a 2-year period in 322 CAD patients (33.2%
female). METHODS: At baseline, perceived social support,
coping style, and social conflict were associated with
stress ratings. Mixed models were used to evaluate
predictors of reported stress during the subsequent 2 years.
RESULTS: The results showed that higher stress was present
in patients who were female and young. Follow-up stress was
also found in patients with moderate income, congestive
heart failure, high social conflict, low social support, and
negative coping style. CONCLUSIONS: These findings may help
clinicians identify patients who are likely to experience
higher levels of stress over a prolonged period following a
diagnosis of CAD and may also suggest which patients may
benefit most from stress reduction interventions.},
Doi = {10.1207/s15324796abm2701_4},
Key = {fds276214}
}
@article{fds276164,
Author = {Boyle, SH and Williams, RB and Mark, DB and Brummett, BH and Siegler,
IC and Helms, MJ and Barefoot, JC},
Title = {Hostility as a predictor of survival in patients with
coronary artery disease.},
Journal = {Psychosom Med},
Volume = {66},
Number = {5},
Pages = {629-632},
Year = {2004},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15385683},
Abstract = {OBJECTIVE: This article presents a reanalysis of an earlier
study that reported a nonsignificant relation between the
50-item Cook-Medley Hostility Scale (CMHS) and survival in a
sample of coronary patients. Since publication of those
results, there have been significant developments in the
measurement of hostility that suggest that an abbreviated
scale may be a better predictor of health outcomes. This
study examined the ability of the total CMHS and an
abbreviated form of the CMHS (ACM) to predict survival in a
sample of patients with documented coronary artery disease
(CAD) with increased statistical power. METHODS: Nine
hundred thirty-six patients (83% were male; mean age =
51.48) with CAD who were followed for an average of 14.9
years. The ACM consisted of the combination of the cynicism,
hostile attribution, hostile affect, and aggressive
responding subscales that were identified in an earlier
study (Barefoot et al. [1989]) by a rational analysis of the
item content. The relation between hostility and survival
was examined with Cox proportional hazard models (hazard
ratios [HRs] based on a two standard deviation difference).
RESULTS: Controlling for disease severity, the ACM was a
significant predictor for both CHD mortality (HR = 1.33, p
<.009) and total mortality (HR = 1.28, p <.02). The total
CMHS was only a marginally significant predictor of either
outcome (p values < 0.06). CONCLUSION: The results of this
study suggest that hostility is associated with poorer
survival in CAD patients, and it may be possible to refine
measures of hostility in order to improve prediction of
health outcomes.},
Doi = {10.1097/01.psy.0000138122.93942.4a},
Key = {fds276164}
}
@article{fds276120,
Author = {Burroughs, AR and Visscher, WA and Haney, TL and Efland, JR and Barefoot, JC and Williams, RB and Siegler, IC},
Title = {Community recruitment process by race, gender, and SES
gradient: lessons learned from the Community Health and
Stress Evaluation (CHASE) Study experience.},
Journal = {Journal of Community Health},
Volume = {28},
Number = {6},
Pages = {421-437},
Year = {2003},
Month = {December},
ISSN = {0094-5145},
url = {http://www.ncbi.nlm.nih.gov/pubmed/14620965},
Abstract = {Recruitment of community participants for clinical research
studies is a challenging task. When possible,
community-based recruitment efforts should involve members
of the targeted community in the planning, community
preparation, and actual recruitment process. It becomes even
more difficult to recruit study participants from the
community when the research involves an invasive procedure,
or when diverse target groups require that a variety of
recruitment methods be used. The Community Health and Stress
Evaluation (CHASE) Study was designed to determine the role
of psychosocial and biobehavioral factors in the etiology of
coronary heart disease. It involved both an invasive medical
procedure (a spinal tap) and the collection of survey and
medical information from Black and White persons in
different socioeconomic status (SES) groups. Interestingly,
we experienced the greatest difficulty in recruiting lower
SES white persons, while groups that typically are
"difficult to find" (such as Blacks) were actually easiest
to recruit for the study. This paper describes the
background of the CHASE study, the community recruitment
methods used, and the results of the recruitment efforts by
race, gender and SES gradient. We present an evaluation of
the community recruitment component, why we think
differences occurred, and the lessons learned from the
experiences that may be applied to similar
studies.},
Doi = {10.1023/a:1026029723762},
Key = {fds276120}
}
@article{fds276213,
Author = {Brummett, BH and Babyak, MA and Siegler, IC and Mark, DB and Williams,
RB and Barefoot, JC},
Title = {Effect of smoking and sedentary behavior on the association
between depressive symptoms and mortality from coronary
heart disease.},
Journal = {The American Journal of Cardiology},
Volume = {92},
Number = {5},
Pages = {529-532},
Year = {2003},
Month = {September},
ISSN = {0002-9149},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12943871},
Abstract = {It has been suggested that one of the mechanisms linking
depression with elevated mortality risk is the association
between depressive symptoms and other established coronary
artery disease (CAD) risk factors, such as smoking and
failure to exercise. The present study examined this
hypothesis using repeated assessments of smoking and
exercise from patients with CAD in whom depressive symptoms
had been shown to predict decreased survival. Initially,
associations between depressive symptoms and the risk
factors of smoking and sedentary behavior were assessed.
Next, patterns of smoking and sedentary behavior were
examined as mediators and/or moderators of the association
between depressive symptoms and mortality. Depressive
symptoms were positively related to smoking (p <0.01) and
sedentary behavior (p <0.01). Depressive symptoms, smoking,
and sedentary behavior were independent predictors of
mortality. Results indicated that smoking and/or sedentary
behavior may partially mediate the relation between
depressive symptoms and mortality. No evidence for
moderation was found.},
Doi = {10.1016/s0002-9149(03)00719-7},
Key = {fds276213}
}
@article{fds276117,
Author = {Yen, S and Siegler, IC},
Title = {Self-blame, social introversion, and male suicides:
Prospective data from a longitudinal study},
Journal = {Archives of Suicide Research : Official Journal of the
International Academy for Suicide Research},
Volume = {7},
Number = {1},
Pages = {17-27},
Publisher = {Informa UK Limited},
Year = {2003},
Month = {April},
url = {http://dx.doi.org/10.1080/13811110301569},
Abstract = {This study examines the use of 7 Minnesota Multiphasic
Personality Inventory (MMPI; Hathaway & Briggs, 1940)
subscales in their ability to differentiate between male
suicide completers and 1) clinically depressed men, and 2) a
deceased control group consisting of men who have died of
medical causes. Data were collected from a nonclinical
student population that was followed longitudinally. The 7
scales, chosen to reflect aspects of coping and emotional
resources include two of the original scales, Defensiveness
(K), Social Introversion (Si), and supplementary scales: Ego
Strength (Es; Barron, 1953), Blaming Self (Bs; Finney,
1965), Impulsivity (Imp; Gough, 1957), Suppression and
Outburst of Hostility (Soh; Finney, 1965), and Motivation to
Change (Mtc; Volsky, Magom, Norman & Hoyt, 1965). Results
indicated that suicide completers had significantly higher
scores on Bs and Si when compared with deceased controls.
These scales were near significant in differentiating
between suicide completers and depressed controls. The
results of this study suggest that those who eventually
commit suicide may endorse greater tendencies toward
self-blame and social introversion during early
adulthood.},
Doi = {10.1080/13811110301569},
Key = {fds276117}
}
@article{fds276119,
Author = {Meissner, HI and Rimer, BK and Davis, WW and Eisner, EJ and Siegler,
IC},
Title = {Another round in the mammography controversy.},
Journal = {Journal of Women'S Health (2002)},
Volume = {12},
Number = {3},
Pages = {261-276},
Year = {2003},
Month = {April},
ISSN = {1540-9996},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12804357},
Abstract = {PURPOSE: The October 2001 publication of a meta-analysis
questioning the scientific basis for recommending screening
mammography sparked yet a new flame of controversy about
this issue. We conducted a national survey in March 2002 to
provide information about women's perspectives on the
issues, including the evidence regarding the efficacy of
mammography and, ultimately, their intentions to continue
screening. METHODS: We added 12 questions to a national
telephone omnibus survey in March 2002 to assess women's
reactions to the ongoing debate. Responses were collected
over three waves of the twice-weekly survey to obtain data
from 733 women between the ages of 40 and 69. The sample was
weighted to the U.S. population for census region, age,
race, ethnicity, and educational attainment. RESULTS:
Consistent with prior studies, most women were getting
regular mammograms (78%) (95% confidence interval [CI]
75%-81%), >90% believed that mammography is effective in
detecting breast cancer (95%) (95% CI 93%-97%) and in
reducing breast cancer mortality (93%) (95% CI 91%-96%), and
only about 22% (95% CI 19%-25%) said they were confused.
Logistic regression analyses revealed sociodemographic
differences among women who had heard about the controversy
and who reported some confusion about mammograms. Women with
lower levels of education, younger women, and those residing
in nonmetropolitan areas were significantly less likely to
be aware of the controversy. Although a majority of women
said they were not confused about mammography, minority
women and women with lower education levels were more likely
to report being confused. There were no significant
demographic differences in intentions to get future
mammograms. Women who were concerned about getting breast
cancer were much more likely to be planning to have future
mammograms than women who were not at all concerned (odds
ratio [OR] 3.63; 95% CI 2.37, 5.56). Likewise, respondents
who said that they had enough information to make decisions
whether to get future mammograms were much more likely to
plan on getting screened than women who said they did not
have enough information (OR 2.47; 95% CI 1.14, 5.40).
CONCLUSIONS: These results do not suggest that controversy
leads to lower rates of adherence. They do indicate that
some women lack the information needed to make informed
decisions about mammography.},
Doi = {10.1089/154099903321667609},
Key = {fds276119}
}
@article{fds276149,
Author = {Williams, RB and Marchuk, DA and Gadde, KM and Barefoot, JC and Grichnik, K and Helms, MJ and Kuhn, CM and Lewis, JG and Schanberg, SM and Stafford-Smith, M and Suarez, EC and Clary, GL and Svenson, IK and Siegler, IC},
Title = {Serotonin-related gene polymorphisms and central nervous
system serotonin function.},
Journal = {Neuropsychopharmacology},
Volume = {28},
Number = {3},
Pages = {533-541},
Year = {2003},
Month = {March},
ISSN = {0893-133X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12629534},
Abstract = {Central nervous system (CNS) serotonergic function affects a
wide range of biological and behavioral functions affecting
health and disease. Our objective in this study was to
determine whether functional polymorphisms of the genes that
encode for the serotonin transporter promoter (5HTTLPR) and
monoamine oxidase A (MAOA-uVNTR) are associated with CNS
serotonin turnover-indexed by cerebrospinal fluid levels of
5-hydroxyindoleacetic acid (5-HIAA)-in a community sample of
healthy adults. Subjects were 165 community volunteers
without current medical or psychiatric illness, stratified
with respect to ethnicity, gender, and socioeconomic status
who underwent inpatient evaluation in the General Clinical
Research Center of a university medical center. A
significant ethnicity x genotype interaction (P=0.008)
indicated that, compared to the long/long and long/short
genotypes, the 5HTTLPR short/short genotype was associated
with higher CSF 5-HIAA levels in African Americans, but with
lower levels in Caucasians. A gender x genotype interaction
(P=0.04) indicated that 5HTTLPR short/short genotype was
associated with higher 5-HIAA levels in women but with lower
levels in men. MAOA-uVNTR 3.5 and 4 repeat alleles were
associated with higher 5-HIAA (P=0.03) levels in men, but
were unrelated to 5-HIAA levels in women. These findings
suggest that effects of serotonin-related gene polymorphisms
on CNS serotonergic function vary as a function of both
ethnicity and gender. Further research will be required to
determine the mechanism(s) underlying these differential
effects. In the meanwhile, both ethnicity and gender should
be taken into account in research evaluating effects of
these and related polymorphisms on CNS serotonergic
function, as well as the broad range of biological and
behavioral functions that are regulated by CNS serotonergic
function.},
Doi = {10.1038/sj.npp.1300054},
Key = {fds276149}
}
@article{fds276162,
Author = {Brummett, BH and Siegler, IC and McQuoid, DR and Svenson, IK and Marchuk, DA and Steffens, DC},
Title = {Associations among the NEO Personality Inventory, Revised
and the serotonin transporter gene-linked polymorphic region
in elders: effects of depression and gender.},
Journal = {Psychiatric Genetics},
Volume = {13},
Number = {1},
Pages = {13-18},
Publisher = {Ovid Technologies (Wolters Kluwer Health)},
Year = {2003},
Month = {March},
url = {http://dx.doi.org/10.1097/00041444-200303000-00002},
Abstract = {OBJECTIVE: The short variant of the serotonin transporter
gene-linked functional polymorphic region (5-HTTLPR) has
been associated with personality traits related to anxiety,
hostility, and depression. We attempted to replicate
findings suggesting a positive relation between the short
allele variant of 5-HTTLPR and Neuroticism, and a negative
association between the short allele variant and
Agreeableness. METHODS: Participants in the present study
were 103 geriatric depressed patients and 99 non-depressed
age matched controls. Depression status and gender were
examined as potential modifiers of the association between
5-HTTLPR and personality. RESULTS: Neuroticism was
associated with allele frequency such that individuals with
the short variant of the allele (ss or sl, group S) were
significantly lower on Neuroticism ( P<0.04) compared with
individuals with the long allele variant (group L), a
pattern opposite to that of previous reports. The
association did not vary by clinical group (depressed or
controls) but was conditional on gender ( P<0.01): the mean
Neuroticism for males in group S was 48.2, whereas the mean
Neuroticism for males in group L was 55.9; and the mean
Neuroticism for females did not differ by allele group. In
the total sample, Agreeableness was not associated with
allele frequency; however, there was a significant allele
groupxclinical groupxgender interaction ( P<0.01).
CONCLUSIONS: The present findings failed to replicate prior
work suggesting that the short variant of the 5-HTTLPR
allele is associated with higher Neuroticism and lower
Agreeableness.},
Doi = {10.1097/00041444-200303000-00002},
Key = {fds276162}
}
@article{fds276118,
Author = {Costa, PT and Siegler, IC},
Title = {Overview},
Journal = {Advances in Cell Aging and Gerontology},
Volume = {15},
Pages = {vii-xix},
Publisher = {Elsevier},
Year = {2003},
Month = {January},
ISSN = {1566-3124},
url = {http://dx.doi.org/10.1016/S1566-3124(03)15001-8},
Doi = {10.1016/S1566-3124(03)15001-8},
Key = {fds276118}
}
@article{fds276163,
Author = {Brummett, BH and Barefoot, JC and Vitaliano, PP and Siegler,
IC},
Title = {Associations among social support, income, and symptoms of
depression in an educated sample: the UNC Alumni Heart
Study.},
Journal = {International Journal of Behavioral Medicine},
Volume = {10},
Number = {3},
Pages = {239-250},
Year = {2003},
ISSN = {1070-5503},
url = {http://www.ncbi.nlm.nih.gov/pubmed/14525719},
Abstract = {It has been suggested that the inverse association between
social support and depression may be stronger in persons
with lower income. This study tested the support x income
hypothesis in a sample of 2,472 individuals enrolled in the
UNC Alumni Heart Study. The income was examined as a
moderator of the relation between support and self-reported
ratings of symptoms of depression. The appraisal subscale of
the Interpersonal Support Evaluation Scale, household income
level, and their interaction were modeled as predictors of
depression ratings. The support x income interaction term
was significantly associated with symptoms of depression, F
(2, 2471)=4.71, p=.007. Social support was more strongly
associated inversely with depression ratings in persons with
lower income as compared to those with higher income. The
present results extend previous work regarding the
moderating effect of income to a sample of relatively high
education and income level.},
Doi = {10.1207/s15327558ijbm1003_04},
Key = {fds276163}
}
@article{fds276165,
Author = {Siegler, IC and Costa, PT and Brummett, BH and Helms, MJ and Barefoot,
JC and Williams, RB and Dahlstrom, WG and Kaplan, BH and Vitaliano, PP and Nichaman, MZ and Day, RS and Rimer, BK},
Title = {Patterns of change in hostility from college to midlife in
the UNC Alumni Heart Study predict high-risk
status.},
Journal = {Psychosom Med},
Volume = {65},
Number = {5},
Pages = {738-745},
Year = {2003},
url = {http://www.ncbi.nlm.nih.gov/pubmed/14508014},
Abstract = {OBJECTIVE: To examine hostility measured in college and
patterns of change in hostility from college to midlife as
predictors of high health-related risk later in midlife.
METHODS: Logistic regression models were used to test
hostility/risk associations. RESULTS: College hostility
predicted being a current smoker, consuming more than two
drinks of alcohol, low social support, achieving less than
expected in career and in relationships, risk for
depression, and appraisal of life changing for the worse in
terms of family events at midlife. Change in hostility did
not predict smoking and drinking; however, it did
significantly predict social isolation, lower income (only
for women), obesity, avoidance of exercise, high-fat diet,
and negative changes in economic life, work life, and
physical health events-all risk indicators measured during
the next decade. Appraisals of social support, lowered
expectations, risk for depression, and reports of family
life changing for the worse were predicted at both time
periods. When change in hostility was modeled with college
hostility, all risk indicators were significantly predicted
by college hostility. CONCLUSIONS: High hostility in college
and change in hostility from college to midlife predicts a
full range of health risk indicators. When compared with the
average population decline in hostility, gains in hostility
at midlife are related to increased risk while declines in
hostility are related to reduced risk. Higher midlife
hostility is associated with increased odds of being in the
higher risk group. Future research should focus on
developing interventions to reduce hostility.},
Doi = {10.1097/01.psy.0000088583.25140.9c},
Key = {fds276165}
}
@article{fds276197,
Author = {Bosworth, HB and Bastian, LA and Rimer, BK and Siegler,
IC},
Title = {Coping styles and personality domains related to menopausal
stress.},
Journal = {Women'S Health Issues : Official Publication of the Jacobs
Institute of Women'S Health},
Volume = {13},
Number = {1},
Pages = {32-38},
Year = {2003},
ISSN = {1049-3867},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12598057},
Abstract = {PURPOSE: Examine the role of coping styles and personality
domains in relationship to stress associated with menopause.
DATA/INFORMATION: Data are from 170 women ages 45 to 54 who
completed a mailed questionnaire and a telephone interview
that assessed women's stress associated with menopause,
coping style, personality, menopausal symptoms, depressive
symptoms, and use of hormone replacement therapy. RESULTS:
Rating menopause as stressful was associated with higher
levels of neuroticism, seeking social support, and
avoidance, and lower levels of agreeableness in unadjusted
analyses. In a multivariate model, menopausal symptoms,
seeking social support, and neuroticism accounted for 21% of
the variance in rating menopause as stressful. CONCLUSIONS:
Health care providers treating women going through menopause
should be aware that the stress response to the menopause
transition is multifactorial and is associated with women's
individual personalities and coping styles.},
Doi = {10.1016/s1049-3867(02)00192-5},
Key = {fds276197}
}
@article{fds276150,
Author = {Bastian, LA and McBride, CM and Fish, L and Lyna, P and Farrell, D and Lipkus, IM and Rimer, BK and Siegler, IC},
Title = {Evaluating participants' use of a hormone replacement
therapy decision-making intervention.},
Journal = {Patient Education and Counseling},
Volume = {48},
Number = {3},
Pages = {283-291},
Year = {2002},
Month = {December},
ISSN = {0738-3991},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12477613},
Abstract = {BACKGROUND: Associations between optimal use of a tailored
decision-aid and levels of accuracy of perceived breast
cancer risk, confidence in decision-making, and satisfaction
with decisions about HRT were evaluated in a randomized
intervention trial with a community sample of women aged
45-54. METHODS: Data are from 289 women randomized to
receive a computer-tailored three-step decision-aid.
RESULTS: Forty-seven percent of participants reported
optimal use of the intervention materials. African American
women and those with low confidence in decision-making were
less likely to use the intervention optimally than white
women and those with higher confidence (P<0.05). Optimal use
of the decision-aid was associated with increased accuracy
of perceived risk and confidence to make a decision.
DISCUSSION: When used optimally, self-directed decision-aids
can improve women's ability to make decisions about HRT.
Additional refinement of these aids is needed. For some
subgroups of women, adjuncts such as telephone counseling
also might be considered.},
Doi = {10.1016/s0738-3991(02)00048-4},
Key = {fds276150}
}
@article{fds276115,
Author = {Barefoot, JC and Grønbaek, M and Feaganes, JR and McPherson, RS and Williams, RB and Siegler, IC},
Title = {Alcoholic beverage preference, diet, and health habits in
the UNC Alumni Heart Study.},
Journal = {American Journal of Clinical Nutrition},
Volume = {76},
Number = {2},
Pages = {466-472},
Year = {2002},
Month = {August},
ISSN = {0002-9165},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12145024},
Abstract = {BACKGROUND: Moderate alcohol intake is related to better
health, and additional benefits may be associated with wine.
However, beverage preference may be confounded by lifestyle
factors related to health. OBJECTIVE: The goal was to
describe the associations between alcoholic-beverage
preferences and indicators of a healthy diet and other
health habits. DESIGN: This cross-sectional study included
data from 2864 men and 1571 women enrolled in the UNC Alumni
Heart Study. Self-reports of drinking habits were used as
predictors of health behaviors and of intakes of nutrients
and food groups. RESULTS: Subjects who preferred wine had
healthier diets than did those who preferred beer or spirits
or had no preference. Wine drinkers reported eating more
servings of fruit and vegetables and fewer servings of red
or fried meats. The diets of wine drinkers contained less
cholesterol, saturated fat, and alcohol and more fiber. Wine
drinkers were less likely to smoke. Compared with all
drinkers, those who drank no alcohol consumed fewer
vegetables but more fiber. Nondrinkers were less likely to
exercise regularly and had a higher mean body mass index.
Controlling for income and education had little effect on
these associations. CONCLUSIONS: The apparent health
benefits of wine compared with other alcoholic beverages, as
described by others, may be a result of confounding by
dietary habits and other lifestyle factors. Confounding by
lifestyle variables could also be a factor in the previously
observed health differences between drinkers and
nondrinkers, although the evidence for this association is
not as strong.},
Doi = {10.1093/ajcn/76.2.466},
Key = {fds276115}
}
@article{fds276196,
Author = {McBride, CM and Bastian, LA and Halabi, S and Fish, L and Lipkus, IM and Bosworth, HB and Rimer, BK and Siegler, IC},
Title = {A tailored intervention to aid decision-making about hormone
replacement therapy.},
Journal = {American Journal of Public Health},
Volume = {92},
Number = {7},
Pages = {1112-1114},
Year = {2002},
Month = {July},
ISSN = {0090-0036},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12084693},
Doi = {10.2105/ajph.92.7.1112},
Key = {fds276196}
}
@article{fds276195,
Author = {Siegler, IC and Bastian, LA and Steffens, DC and Bosworth, HB and Costa,
PT},
Title = {Behavioral medicine and aging.},
Journal = {Journal of Consulting and Clinical Psychology},
Volume = {70},
Number = {3},
Pages = {843-851},
Year = {2002},
Month = {June},
ISSN = {0022-006X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12090387},
Abstract = {A brief history of behavioral medicine and aging is followed
by a series of perspectives that help to understand how age
is used as a variable in this research, the relative
importance of age to declines in cognitive functioning, and
the impact of behavioral risk indicators on healthy
survival. The authors discuss Alzheimer's disease and the
role of age in clinical practice. Also discussed are
potential problems in age-related research, ways to improve
the knowledge base in behavioral medicine and aging, and
thoughts about future challenges to enhance work in
behavioral medicine and aging.},
Doi = {10.1037//0022-006x.70.3.843},
Key = {fds276195}
}
@article{fds276233,
Author = {Surwit, RS and Williams, RB and Siegler, IC and Lane, JD and Helms, M and Applegate, KL and Zucker, N and Feinglos, MN and McCaskill, CM and Barefoot, JC},
Title = {Hostility, race, and glucose metabolism in nondiabetic
individuals.},
Journal = {Diabetes Care},
Volume = {25},
Number = {5},
Pages = {835-839},
Year = {2002},
Month = {May},
ISSN = {0149-5992},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11978677},
Abstract = {OBJECTIVE: The present study was designed to determine
whether hostility is differentially related to measures of
glucose metabolism in African-Americans and Caucasians.
RESEARCH DESIGN AND METHODS: The relationship of hostility,
as measured by a subset of the Cook-Medley hostility scale
(CMHOST) inventory items, to various parameters of glucose
metabolism were examined in a young, healthy sample of male
and female African-American and Caucasian volunteers.
Fasting blood samples were collected during an inpatient
admission, at which time the CMHOST was also administered.
RESULTS: In the entire sample, the CMHOST was found to be
significantly correlated with fasting glucose and insulin
sensitivity, as measured by the homeostatic model assessment
(HOMA). However, the relationship of hostility to these
parameters of glucose metabolism was different in
African-American and Caucasian subjects. Hostility was
significantly related to fasting glucose in
African-Americans and to insulin sensitivity and fasting
insulin in Caucasian subjects. The relationship of hostility
to insulin sensitivity and fasting insulin was partially
dependent on BMI in Caucasians, but the relationship of
hostility to fasting glucose was unrelated to BMI in
African-Americans. CONCLUSIONS: Our data suggest that the
relationship of hostility to measures of glucose metabolism
is mediated differently in these two ethnic groups.
Therefore, hostility seems to be part of a constellation of
risk-related behaviors related to BMI in Caucasians but
independently related to fasting glucose in
African-Americans.},
Doi = {10.2337/diacare.25.5.835},
Key = {fds276233}
}
@article{fds276116,
Author = {Vitaliano, PP and Scanlan, JM and Zhang, J and Savage, MV and Hirsch,
IB and Siegler, IC},
Title = {A path model of chronic stress, the metabolic syndrome, and
coronary heart disease.},
Journal = {Psychosomatic Medicine},
Volume = {64},
Number = {3},
Pages = {418-435},
Year = {2002},
ISSN = {0033-3174},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12021416},
Abstract = {OBJECTIVE: We tested a theoretical stress model
cross-sectionally and prospectively that examined whether
relationships of chronic stress, psychophysiology, and
coronary heart disease (CHD) varied in older adult men (N =
47), older adult women not using hormone replacement therapy
(HRT) (N = 64), and older adult women using HRT (N = 41).
METHOD: Structural equations examined relationships of CHD
with 1) chronic stress (caring for a spouse with Alzheimer's
disease and patient functioning), 2) vulnerability (anger
and hostility), 3) social resources (supports), 4)
psychological distress (burden, sleep problems, and low
uplifts), 5) poor health habits (high-caloric, high-fat diet
and limited exercise), and 6) the metabolic syndrome (MS)
(blood pressure, obesity, insulin, glucose, and lipids).
RESULTS: Caregiver men had a greater prevalence of CHD
(13/24) than did noncaregiver men (6/23) (p <.05) 27 to 30
months after study entry. This was influenced by pathways
from caregiving to distress, distress to the MS, and the MS
to CHD. In men, poor health habits predicted the MS 15 to 18
months later, and the MS predicted new CHD cases over 27 to
30 months. In women, no "caregiving-CHD" relationship
occurred; however, 15 to 18 months after study entry women
not using HRT showed "distress-MS" and "MS-CHD"
relationships. In women using HRT, associations did not
occur among distress, the MS, and CHD, but poor health
habits and the MS were related. CONCLUSIONS: In older men,
pathways occurred from chronic stress to distress to the
metabolic syndrome, which in turn predicted CHD. Older women
not using HRT showed fewer pathways than men; however, over
time, distress, the MS, and CHD were related. No
psychophysiological pathways occurred in older women using
HRT.},
Doi = {10.1097/00006842-200205000-00006},
Key = {fds276116}
}
@article{fds276142,
Author = {Steffens, DC and Svenson, I and Marchuk, DA and Levy, RM and Hays, JC and Flint, EP and Krishnan, KRR and Siegler, IC},
Title = {Allelic differences in the serotonin transporter-linked
polymorphic region in geriatric depression.},
Journal = {American Journal of Geriatric Psychiatry},
Volume = {10},
Number = {2},
Pages = {185-191},
Year = {2002},
ISSN = {1064-7481},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11925279},
Abstract = {Previous studies have examined the role of genetic
variations in the serotonin transporter-linked polymorphic
region (5HTTLPR) in affective disorders. The authors studied
182 older depressed subjects and 107 elderly control
subjects and obtained DNA for genotyping at the 5HTTLPR.
There were no significant differences in allele frequencies
generally or for number of short alleles for the group as a
whole, but interesting gender effects emerged. Among men,
23% of depressed men had two short alleles, compared with
only 5% of control subjects. Among women, 67% of depressed
women with more than one episode had at least one short
allele, compared with 41% of single-episode female patients.
Also, 74% of women with a positive family history of
psychiatric illness in any female relative had at least one
short allele, whereas 53% had at least one short allele who
did not have such a family history. Our results add to the
literature linking this gene to affective illness. The
negative association of allele frequency and depression may
be related to the relatively small sample size. The findings
raise the possibility that this genetic locus may exert
differential effects based on gender, increasing risk in
men, and increasing risk of recurrence in
women.},
Doi = {10.1176/appi.ajgp.10.2.185},
Key = {fds276142}
}
@article{fds276194,
Author = {Bosworth, HB and Siegler, IC},
Title = {Terminal change in cognitive function: an updated review of
longitudinal studies.},
Journal = {Experimental Aging Research},
Volume = {28},
Number = {3},
Pages = {299-315},
Year = {2002},
ISSN = {0361-073X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12079580},
Abstract = {We provide an update to Siegler's (1975) review of the
terminal change literature. Articles identified through
MEDLINE, CANCERLIT, PUBMED, and PSYCINFO from 1975 to 2000
were examined. Lower levels of cognitive function are
related to increased risk of mortality; however, the
relationship between rate of cognitive change and mortality
is less clear. Although there has been an increase in the
number of studies since our last review, prior studies have
been limited by a lack of medical data, consideration of
dementia, small sample sizes, and poor cognitive measures.
The emphasis on Alzheimer's disease and the growth of
epidemiology of aging in the past 25 years have provided
well-characterized population studies with serial cognitive
measures that provide an opportunity to test the theory of
terminal change.},
Doi = {10.1080/03610730290080344},
Key = {fds276194}
}
@article{fds276212,
Author = {Brummett, BH and Babyak, MA and Mark, DC and Williams, RB and Siegler,
IC and Clapp-Channing, N and Barefoot, JC},
Title = {Predictors of smoking cessation in patients with a diagnosis
of coronary artery disease.},
Journal = {Journal of Cardiopulmonary Rehabilitation},
Volume = {22},
Number = {3},
Pages = {143-147},
Year = {2002},
ISSN = {0883-9212},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12042680},
Abstract = {PURPOSE: This study aimed to examine demographic,
psychosocial, and clinical variables as predictors of
smoking cessation in patients with coronary artery disease.
METHODS: Smoking status and psychosocial variables were
obtained at baseline. Participants were followed up at 3
months then annually up to 6 years for smoking status.
Participants were recruited from the population of patients
undergoing coronary angiography from 1986 through 1990.
Patients were included in the study if they reported smoking
at baseline and had valid data for demographic and clinical
measures of interest. Depending on the psychosocial measure
analyzed, sample size ranged from 525 to 303. Age, gender,
education, marital status, disease severity, cardiac
procedure, hostility, and four ratings of distress were
evaluated as predictors of smoking cessation. RESULTS: Of
the full sample, 40% (n = 210) quit smoking without relapse.
Education (odds ratio [OR] 0.61; 95% confidence interval
[CI] 0.44-0.84; P <.003), disease severity (OR 0.58; 95% CI
0.40-0.84; P <.004), and coronary artery bypass surgery (OR
0.60; 95% CI 0.43-0.85; P <.004) were associated with a
lower likelihood of relapse. Higher levels of hostility (OR
2.36; 95% CI 1.46-3.84; P <.001), concern about health (OR
1.90; 95% CI 1.33-2.74; P <.001), tension (OR 1.60; 95% CI
1.12-2.30; P <.012), and depressive feelings (OR 1.60; 95%
CI 1.12-2.27; P <.010) were associated with a higher risk of
continuing to smoke. CONCLUSIONS: These findings describe
demographic, clinical, and psychological mechanisms that
might underlie successful smoking cessation and also may
guide the identification of patients in need of special
intervention.},
Doi = {10.1097/00008483-200205000-00003},
Key = {fds276212}
}
@article{fds276192,
Author = {Calhoun, PS and Bosworth, HB and Siegler, IC and Bastian,
LA},
Title = {The relationship between hostility and behavioral risk
factors for poor health in women veterans.},
Journal = {Preventive Medicine},
Volume = {33},
Number = {6},
Pages = {552-557},
Year = {2001},
Month = {December},
ISSN = {0091-7435},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11716650},
Abstract = {BACKGROUND: While previous research has generally supported
a relationship between hostility and health risk behaviors,
the majority of this research has been conducted in
predominately male, highly educated, Caucasian samples. The
current study was designed to further examine the
relationship between hostility and health risk behaviors in
a sample of women. METHODS: Measures of health risk behavior
and scores from the Cook-Medley hostility scale were
obtained from 409 women veterans. Linear and logistic
regression analyses were used to examine the relationship
between hostility and health behaviors including tobacco
smoking, alcohol use, body-mass index, caffeine use, and
level of physical activity, after sociodemographic factors
were accounted for. RESULTS: In a cohort of women veterans
using VA health care, ages 35-81, hostility was
significantly associated with tobacco smoking (OR = 2.10;
95% CI = 1.34 to 3.30), caffeine use (OR = 2.12; 95% CI =
1.16 to 3.85), and the number of alcoholic beverages
consumed by women who drink alcohol. Hostility was not
associated with body mass index (OR = 1.15; 95% CI = 0.77 to
1.72) or a lack of physical exercise (OR = 0.89; 95% CI =
0.55 to 1.43). CONCLUSIONS: Results are generally consistent
with previous research and support the relationship between
hostility and health risk behaviors. Awareness that
hostility contributes to risk behaviors and disease may help
in the design of interventions aimed at risk
reduction.},
Doi = {10.1006/pmed.2001.0921},
Key = {fds276192}
}
@article{fds276193,
Author = {Weng, HH and McBride, CM and Bosworth, HB and Grambow, SC and Siegler,
IC and Bastian, LA},
Title = {Racial differences in physician recommendation of hormone
replacement therapy.},
Journal = {Preventive Medicine},
Volume = {33},
Number = {6},
Pages = {668-673},
Year = {2001},
Month = {December},
ISSN = {0091-7435},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11716665},
Abstract = {PURPOSE: Previous studies have suggested that black women
may be less likely than white women to be offered and to
take hormone replacement therapy (HRT). Thus, race and other
factors associated with physician recommendation of HRT that
may influence women's decisions about HRT were examined.
METHODS: Data were from a baseline assessment of
participants in a randomized controlled trial designed to
evaluate the efficacy of a tailored decision-aid on HRT
decision-making. We telephone interviewed 581 Durham women
ages 45-54. The association of race and other factors with
reported physician recommendation of HRT was tested using
chi(2) and logistic regression analysis. RESULTS: Overall,
45% of women surveyed reported that their physician
recommended HRT; black women were significantly less likely
than white women to report being advised about HRT (35% vs.
48%, respectively, P < 0.005). Additional factors associated
with being recommended HRT included older age, being
postmenopausal, having had a hysterectomy, having thought
about the benefits of HRT, and being satisfied with
information about HRT. CONCLUSIONS: Black women are less
likely than white women to receive physician recommendation
of HRT. Racial differences in patient-provider communication
about HRT exist and thus require greater diligence on the
part of health care providers to minimize such a
gap.},
Doi = {10.1006/pmed.2001.0943},
Key = {fds276193}
}
@article{fds276211,
Author = {ENRICHD Investigators},
Title = {Enhancing recovery in coronary heart disease (ENRICHD):
baseline characteristics.},
Journal = {The American Journal of Cardiology},
Volume = {88},
Number = {3},
Pages = {316-322},
Year = {2001},
Month = {August},
ISSN = {0002-9149},
url = {http://dx.doi.org/10.1016/s0002-9149(01)01652-6},
Doi = {10.1016/s0002-9149(01)01652-6},
Key = {fds276211}
}
@article{fds276159,
Author = {Vitaliano, PP and Scanlan, JM and Zhang, J and Savage, MV and Brummett,
B and Barefoot, J and Siegler, IC},
Title = {Are the salutogenic effects of social supports modified by
income? A test of an "added value hypothesis".},
Journal = {Health Psychology : Official Journal of the Division of
Health Psychology, American Psychological
Association},
Volume = {20},
Number = {3},
Pages = {155-165},
Year = {2001},
Month = {May},
ISSN = {0278-6133},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11403213},
Abstract = {Older adults (54 men, 113 women; M age = 69.5 years) were
examined to test the hypothesis that social supports would
be more salutogenic (health promoting) for persons with
lower incomes than for persons with higher incomes.
Interactions of income and social supports (mean of 3
emotional scales of the Interpersonal Support Evaluation
List) at study entry predicted changes 15-18 months later in
a cardiovascular composite (linear combination of
high-density lipoproteins-mean arterial pressure; p < .05),
and natural killer cell activity (p < .05). For both
outcomes, emotional supports were salutogenic for persons
with lower incomes (< or =$29,000/year), but not for persons
with higher incomes (>$29,000/year). In contrast,
interactions of the Tangible Support Scale with income did
not occur. Persons with lower incomes may derive benefits
from social supports that go beyond tangible
assistance.},
Doi = {10.1037//0278-6133.20.3.155},
Key = {fds276159}
}
@article{fds276191,
Author = {Bosworth, HB and Feaganes, JR and Vitaliano, PP and Mark, DB and Siegler, IC},
Title = {Personality and coping with a common stressor: cardiac
catheterization.},
Journal = {Journal of Behavioral Medicine},
Volume = {24},
Number = {1},
Pages = {17-31},
Year = {2001},
Month = {February},
ISSN = {0160-7715},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11296468},
Abstract = {The association between coping and personality was examined
in a sample of 204 cardiac catheterization patients who were
asked to evaluate the use of specific coping strategies used
to deal with their cardiac catheterization. Personality, as
measured by the NEO Five-Factor Inventory (FFI), was
moderately correlated with coping measures. In multivariate
analyses, after considering confounding factors, Neuroticism
was positively and Extraversion was negatively related to
avoidance coping and Neuroticism was negatively associated
with counting one's blessings as a coping strategy.
Personality was not related to either problem solving or
seeking social support coping strategies for individuals
experiencing a cardiac catheterization. However, important
covariates were associated with coping strategies. Not being
married was negatively correlated with use of seeking social
support and not having a confidant was negatively related
with seeking social support and positively with avoidance.
These results suggest that there are specific relationships
between personality and coping, but these relationships are,
for the most part, moderate in persons coping with a cardiac
catheterization, and that coping processes are associated
with individual differences in available social
resources.},
Doi = {10.1023/a:1005682303815},
Key = {fds276191}
}
@article{fds276161,
Author = {Siegler, IC and Brummett, BH},
Title = {Erratum: Association among NEO personality assessment and
well-being at midlife: Facet-level analyses (Psychology and
Aging (2000) 15:4 (710-714))},
Journal = {Psychology and Aging},
Volume = {16},
Number = {1},
Pages = {144},
Year = {2001},
Month = {January},
ISSN = {0882-7974},
url = {http://dx.doi.org/10.1037/h0087880},
Doi = {10.1037/h0087880},
Key = {fds276161}
}
@article{fds276114,
Author = {Bastian, LA and Owens, SS and Kim, H and Barnett, LR and Siegler,
IC},
Title = {Cigarette smoking in veteran women: the impact of job
strain.},
Journal = {Women'S Health Issues : Official Publication of the Jacobs
Institute of Women'S Health},
Volume = {11},
Number = {2},
Pages = {103-109},
Year = {2001},
ISSN = {1049-3867},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11275513},
Abstract = {To evaluate the health effects of role overload, the
relationship between multiple role (i.e., worker, spouse,
caretaker) strain and current cigarette smoking was
examined. A cross-sectional survey of women veterans, aged
36-85 years, was performed measuring home and job strain and
health behaviors. Of the 275 women who rated both their work
and home strains, 25% (n = 69) currently smoke cigarettes.
Higher work strain, but not higher home strain, was
associated with smoking adjusting for age, education,
income, weight, and marital status. A stressful work
environment may trigger persistent smoking and should be
addressed during smoking cessation counseling.},
Doi = {10.1016/s1049-3867(00)00077-3},
Key = {fds276114}
}
@article{fds276148,
Author = {Williams, RB and Marchuk, DA and Gadde, KM and Barefoot, JC and Grichnik, K and Helms, MJ and Kuhn, CM and Lewis, JG and Schanberg, SM and Stafford-Smith, M and Suarez, EC and Clary, GL and Svenson, IK and Siegler, IC},
Title = {Central nervous system serotonin function and cardiovascular
responses to stress.},
Journal = {Psychosomatic Medicine},
Volume = {63},
Number = {2},
Pages = {300-305},
Year = {2001},
ISSN = {0033-3174},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11292279},
Abstract = {OBJECTIVE: The objective of this study was to evaluate the
impact of indices of central nervous system (CNS) serotonin
function on cardiovascular reactivity to mental stress.
METHODS: Lumbar puncture was performed on 54 healthy
volunteers to obtain cerebrospinal fluid (CSF) for
determination of 5-hydroxyindoleacetic acid (5HIAA) levels.
Genotypes were determined with respect to a functional
polymorphism of the serotonin transporter gene promoter
region (5HTTLPR). Subjects then underwent mental stress
testing. RESULTS: Persons with one or two long (l) 5HTTLPR
alleles had CSF levels of the major serotonin metabolite,
5HIAA, that were 50% higher than those of persons with the
s/s 5HTTLPR genotype. Persons with one or two l alleles or
higher CSF 5HIAA levels also exhibited greater blood
pressure and heart rate responses to a mental stress
protocol. CONCLUSIONS: These findings suggest the 5HTTLPR
polymorphism affects CNS serotonin function, and they are
consistent with the general hypothesis that CNS serotonin
function is involved in the regulation of potentially
health-damaging biobehavioral characteristics. In
particular, the l allele could contribute, through its
association with increased cardiovascular reactivity to
stress, to increased risk of cardiovascular
disease.},
Doi = {10.1097/00006842-200103000-00016},
Key = {fds276148}
}
@article{fds276189,
Author = {Bosworth, HB and Bastian, LA and Kuchibhatla, MN and Steffens, DC and McBride, CM and Skinner, CS and Rimer, BK and Siegler,
IC},
Title = {Depressive symptoms, menopausal status, and climacteric
symptoms in women at midlife.},
Journal = {Psychosomatic Medicine},
Volume = {63},
Number = {4},
Pages = {603-608},
Year = {2001},
ISSN = {0033-3174},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11485114},
Abstract = {OBJECTIVE: Previous studies have found increased rates of
depression in women aged 45 to 54 years, but the factors
that influence these rates are not understood. It was
assessed whether higher rates of depressive symptoms were
associated with menopausal status, climacteric symptoms, and
use of hormone replacement therapy. DESIGN: Cross-sectional
survey. SETTING: Community sample. METHODS: Data are from
581 women ages 45 to 54 years who were interviewed by
telephone between October 1998 and February 1999. MEASURES:
Depression was measured with the abbreviated CES-D, a
depressive symptoms screening measure. Women's reported
perception of menopausal stage, frequency of periods in the
preceding 12 months, and history of oophorectomy were used
to classify their menopausal status into four categories:
(1) no indication of menopause; (2) close to menopause; (3)
had begun menopause; and (4) had completed menopause.
RESULTS: There were 168 women (28.9%) who reported a high
level (> or = 10) of depressive symptoms when the
abbreviated CES-D was used. In a logistic-regression
analysis, significant factors associated with increased
depressive symptoms included physical inactivity, inadequate
income, use of estrogen/progesterone combination, and
presence of climacteric symptoms (trouble sleeping, mood
swings, or memory problems). Menopausal status was not
associated with depressive symptoms. CONCLUSIONS: In this
sample of women age 45 to 54 years, climacteric symptoms but
not menopausal status were associated with higher rates of
depressive symptoms.},
Doi = {10.1097/00006842-200107000-00013},
Key = {fds276189}
}
@article{fds276190,
Author = {Brummett, BH and Barefoot, JC and Siegler, IC and Clapp-Channing, NE and Lytle, BL and Bosworth, HB and Williams, RB and Mark,
DB},
Title = {Characteristics of socially isolated patients with coronary
artery disease who are at elevated risk for
mortality.},
Journal = {Psychosomatic Medicine},
Volume = {63},
Number = {2},
Pages = {267-272},
Year = {2001},
ISSN = {0033-3174},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11292274},
Abstract = {OBJECTIVES: Social isolation has been linked to poor
survival in patients with coronary artery disease (CAD). Few
studies have closely examined the psychosocial
characteristics of CAD patients who lack social contact.
METHODS: Social isolation was examined as a predictor of
mortality in 430 patients with significant CAD. More
isolated patients were compared with their less isolated
counterparts on factors that might help explain the
association between isolation and survival. RESULTS: The
mortality rate was higher among isolated individuals. Those
with three or fewer people in their social support network
had a relative risk of 2.43 (p = .001) for cardiac mortality
and 2.11 (p = .001) for all-cause mortality, controlling for
age and disease severity. Adjustments for income, hostility,
and smoking status did not alter the risk due to social
isolation. With the exception of lower income, higher
hostility ratings, and higher smoking rates, isolated
patients did not differ from nonisolated patients on
demographic indicators, disease severity, physical
functioning, or psychological distress. Isolated patients
reported less social support and were less pleased with the
way they got along with network members, but they did not
report less satisfaction with the amount of social contact
received. CONCLUSIONS: Patients with small social networks
had an elevated risk of mortality, but this greater risk was
not attributable to confounding with disease severity,
demographics, or psychological distress. These findings have
implications for mechanisms linking social isolation to
mortality and for the application of psychosocial
interventions.},
Doi = {10.1097/00006842-200103000-00010},
Key = {fds276190}
}
@article{fds276210,
Author = {ENRICHD Investigators},
Title = {Enhancing Recovery in Coronary Heart Disease (ENRICHD) study
intervention: rationale and design.},
Journal = {Psychosomatic Medicine},
Volume = {63},
Number = {5},
Pages = {747-755},
Year = {2001},
ISSN = {0033-3174},
Abstract = {OBJECTIVE: Depression and low social support are risk
factors for medical morbidity and mortality after acute MI.
The ENRICHD study is a multicenter, randomized, controlled
clinical trial of a cognitive-behavioral treatment for
depression and low social support in post-MI patients. A
total of 2481 patients were recruited (26% with low social
support, 39% with depression, and 34% with low social
support and depression). Our objective is to describe the
rationale, design, and delivery of the ENRICHD intervention.
METHODS: Key features of the intervention include the
integration of cognitive-behavioral and social learning
approaches to the treatment of depression and a diverse set
of problems that can contribute to low social support; rapid
initiation of treatment after MI; a combination of
individual and group modalities; adjunctive pharmacotherapy
for severe or intractable depression; training,
certification, and supervision of therapists; and quality
assurance procedures. RESULTS: The trial's psychosocial and
medical outcomes will be presented in future reports.
CONCLUSIONS: The ENRICHD protocol targets two complex
psychosocial risk factors with a multifaceted intervention,
which is delivered in an individualized manner to
accommodate a demographically, medically, and
psychiatrically diverse patient population. Additional
research will be needed to identify optimal matches between
patient characteristics and specific components of the
intervention.},
Key = {fds276210}
}
@article{fds276112,
Author = {Herbst, JH and McCrae, RR and Costa, PT and Feaganes, JR and Siegler,
IC},
Title = {Self-perceptions of stability and change in personality at
midlife: the UNC Alumni Heart Study.},
Journal = {Assessment},
Volume = {7},
Number = {4},
Pages = {379-388},
Year = {2000},
Month = {December},
ISSN = {1073-1911},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11151963},
Abstract = {The finding of personality stability in adulthood may be
counterintuitive to people who perceive a great deal of
change in their own personality. The purpose of this study
is to determine whether self-reported perceived changes in
personality are associated with actual changes based on a 6-
to 9-year follow-up of 2,242 middle-aged male and female
participants of the UNC Alumni Heart Study (UNCAHS).
Respondents completed the Revised NEO Personality Inventory
on two occasions and were asked to reflect back over a
6-year period and assess changes in their personality. The
majority of respondents (n = 1,177; 52.5%) reported they had
"stayed the same," while 863 (38.5%) reported they had
"changed a little" and 202 (9%) reported they had "changed a
good deal." Coefficients of personality profile agreement
computed to evaluate global personality change for the three
perceived change groups were essentially equivalent.
Further, directional analyses of domain-specific changes in
personality showed that perceived changes were weak
predictors of residual gain scores. In an absolute sense,
perceptions of stability or change were discordant in 8 of
15 (53%) comparisons. Self-perceptions of change are not an
adequate substitute for objective assessments.},
Doi = {10.1177/107319110000700406},
Key = {fds276112}
}
@article{fds276113,
Author = {Costa, PT and Herbst, JH and McCrae, RR and Siegler,
IC},
Title = {Personality at midlife: stability, intrinsic maturation, and
response to life events.},
Journal = {Assessment},
Volume = {7},
Number = {4},
Pages = {365-378},
Year = {2000},
Month = {December},
ISSN = {1073-1911},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11151962},
Abstract = {Although developmental theories and popular accounts suggest
that midlife is a time of turmoil and change, longitudinal
studies of personality traits have generally found stability
of rank order and little or no change in mean levels. Using
data from 2,274 men and women in their 40s retested after 6
to 9 years, the present study examined two hypotheses: (a)
that retest correlations should be no higher than about .60
and (b) that there should be small decreases in Neuroticism,
Extraversion, and Openness, and small increases in
Agreeableness and Conscientiousness. The study also explored
the effects of recalled life events on subsequent
personality scores. Results did not support the first
hypothesis; uncorrected retest correlations uniformly
exceeded .60. This was true for all personality traits,
including facets of Agreeableness and Conscientiousness not
previously included in longitudinal studies. The
hypothesized decreases in Neuroticism, Extraversion, and
Openness were found, but Conscientiousness showed a small
decrease instead of the predicted increase. Life events in
general showed very little influence on the levels of
personality traits, although some effects were seen for
changes in job and marital status that warrant further
research.},
Doi = {10.1177/107319110000700405},
Key = {fds276113}
}
@article{fds276155,
Author = {Siegler, IC and Brummett, BH},
Title = {Associations among NEO personality assessments and
well-being at midlife: facet-level analyses.},
Journal = {Psychology and Aging},
Volume = {15},
Number = {4},
Pages = {710-714},
Year = {2000},
Month = {December},
ISSN = {0882-7974},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11144330},
Abstract = {The association between well-being and personality was
examined in 2,379 middle-aged adults. Measures that parallel
C. D. Ryffs (1989) psychological model were selected to
assess well-being. The 30 facet scales of the NEO-PI-R were
used to measure personality. More than 83% of the
facet-well-being correlations within the domains of
Neuroticism, Extraversion, and Conscientiousness reached
statistical significance, whereas, less than half of the
correlations within the domains of Agreeableness and
Openness were significant. The facets within each domain
demonstrated different patterns of associations with the
well-being measures, indicating that facet-level assessments
yield additional information.},
Doi = {10.1037//0882-7974.15.4.710},
Key = {fds276155}
}
@article{fds276160,
Author = {Brummett, BH and Barefoot, JC and Siegler, IC and Steffens,
DC},
Title = {Relation of subjective and received social support to
clinical and self-report assessments of depressive symptoms
in an elderly population.},
Journal = {Journal of Affective Disorders},
Volume = {61},
Number = {1-2},
Pages = {41-50},
Year = {2000},
Month = {December},
ISSN = {0165-0327},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11099739},
Abstract = {BACKGROUND: The authors sought to evaluate the associations
between depressive symptoms and social support in a sample
drawn from a relatively understudied population - depressed
elderly patients. The present study also used a
multi-measure approach to assess both depressive
symptomatology and social support. METHODS: In this
prospective study of 115 patients we examined: (1) the
baseline relations among a self-report measure of depressive
symptoms, two clinical assessments of depressive symptoms,
and subjective and received social support, and (2) the
ability of social support to predict changes in clinical
assessments of depressive symptoms at 6 months and 1 year.
Education level, financial concerns, activities of daily
living ratings, and gender were controlled for. RESULTS:
Baseline subjective support was negatively related to
self-reports of depressive symptoms, but unrelated to
clinical assessments at baseline or follow-up. Conversely,
received support was unrelated to self-reported depressive
symptoms, but positively related to both clinical
assessments at baseline. However, higher ratings of received
support at baseline predicted decreases in clinical ratings
of depressive symptoms at 6 months and 1 year. LIMITATIONS:
These data were gathered in a primarily Caucasian sample,
thus the findings may not generalize to more diverse ethnic
populations. Potential confounding due to treatment mode and
setting was not controlled in the present analyses.
CONCLUSIONS: These results have important implications for
interpreting clinical data in elderly depressed patients.
Specifically, when depressive symptoms are assessed using
clinician ratings, the most informative aspect of social
support with respect to future clinical status appears to be
received, rather than perceived, support
measures.},
Doi = {10.1016/s0165-0327(99)00191-3},
Key = {fds276160}
}
@article{fds276242,
Author = {Poon, LW and Johnson, MA and Davey, A and Dawson, DV and Siegler, IC and Martin, P},
Title = {Psycho-social predictors of survival among
centenarians},
Journal = {Facts, Research and Intervention in Geriatrics},
Volume = {2000},
Pages = {77-89},
Year = {2000},
Month = {December},
Abstract = {In this paper, we identified predictors of extreme survival
among a group of 137 centenarians (75.9% women)
participating in the Georgia Centenarian Study, of whom 21
were still living as of March 15, 1999. At the time of
initial testing, centenarians had a mean age of 100.8 years
with a range from 99 to 110 years. Cox regression models
were used to identify significant predictors of mortality.
Results suggest that men, Whites, and those with greater
PADL impairments had higher risks of mortality. Two
surprising findings also emerged. Those with greater triceps
skinfold measures, and those with lower verbal IQs had lower
risks of mortality. Among centenarians, the latter two
findings may actually reflect better nutritional status and
lower blood pressure, respectively. Thus, even in extreme
old age, individual characteristics continue to exert
systematic influences on survival.},
Key = {fds276242}
}
@article{fds276156,
Author = {Brummett, BH and Maynard, KE and Haney, TL and Siegler, IC and Barefoot,
JC},
Title = {Reliability of interview-assessed hostility ratings across
mode of assessment and time.},
Journal = {Journal of Personality Assessment},
Volume = {75},
Number = {2},
Pages = {225-236},
Year = {2000},
Month = {October},
ISSN = {0022-3891},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11020141},
Abstract = {These studies addressed 2 questions concerning
interview-based hostility assessments: whether they are
affected if the interview is conducted face-to-face versus
telephone and whether they are stable across an extended
time period. In Study 1A, 54 students were interviewed
face-to-face and by telephone in a laboratory setting. Half
the sample was reinterviewed in the laboratory 6 weeks
later. The other half was reinterviewed by telephone at
home. With 1 exception, all intraclass correlation
coefficients (ICCs) comparing interview modes were above
.62. In Study 1B, 48 adults were interviewed face-to-face in
a laboratory and by telephone in their homes with a 2-week
intervening interval. The ICC comparing interview modes was
.78. In Study 2, 100 adults were interviewed face-to-face in
a laboratory and approximately 4 years later by telephone in
their homes. The ICC across interviews was .69. Thus,
support was found for the stability of interview-based
hostility assessments across interview methods and extended
periods of time.},
Doi = {10.1207/S15327752JPA7502_4},
Key = {fds276156}
}
@article{fds276185,
Author = {Lipkus, IM and Kuchibhatla, M and McBride, CM and Bosworth, HB and Pollak, KI and Siegler, IC and Rimer, BK},
Title = {Relationships among breast cancer perceived absolute risk,
comparative risk, and worries.},
Journal = {Cancer Epidemiology, Biomarkers & Prevention : a Publication
of the American Association for Cancer Research, Cosponsored
by the American Society of Preventive Oncology},
Volume = {9},
Number = {9},
Pages = {973-975},
Year = {2000},
Month = {September},
ISSN = {1055-9965},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11008917},
Abstract = {When trying to predict breast cancer screening, it may be
important to understand the relationships between perceived
breast cancer risks and worries about getting breast cancer.
This study examines the extent to which women's worries
about breast cancer correlate with perceptions of both
absolute (assessment of own) and comparative (self versus
other) 10-year and lifetime risks. As part of a larger
randomized intervention trial concerning hormone replacement
therapy, 581 women participated in a telephone baseline
survey to assess their perceptions of breast cancer risks
and worries. Worries about getting breast cancer in the next
10 years and in one's lifetime were related positively to
both absolute and comparative 10-year and lifetime risks.
The magnitude of these relationships did not differ by time
frame. Worry about breast cancer is a function of both how a
woman views her own risk and how she compares her risk with
that of other women. Some practitioners may encourage women
to get screened for breast cancer by using emotional
appeals, such as heightening women's worries about breast
cancer by using risk information. Our data suggest that they
should give careful consideration how best to combine, if at
all, information about absolute and comparative risks. For
example, if the motivation to screen is based on a
sequential assessment of risk beginning with comparative and
then absolute risk, creating communications that heighten
perceived risk on both of these risk dimensions may be
needed to evoke sufficient worry to initiate breast cancer
screening.},
Key = {fds276185}
}
@article{fds276157,
Author = {Barefoot, JC and Brummett, BH and Clapp-Channing, NE and Siegler, IC and Vitaliano, PP and Williams, RB and Mark, DB},
Title = {Moderators of the effect of social support on depressive
symptoms in cardiac patients.},
Journal = {The American Journal of Cardiology},
Volume = {86},
Number = {4},
Pages = {438-442},
Year = {2000},
Month = {August},
ISSN = {0002-9149},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10946039},
Abstract = {Social support and depression have been shown to affect the
prognosis of coronary patients, and social support has been
found to influence depression in community and patient
samples. We investigated the characteristics of coronary
patients whose depressive symptomatology was most likely to
improve with social support. We predicted that social
support would be most beneficial for the most severely
depressed, the old, the poor, the most severely ill, and
those with poor functional status. Patients (n = 590) with
documented coronary artery disease were assessed for
depressive symptoms, social support, and functional status
while in hospital. They were reassessed for depression 1
month later during a home visit. Depression scores were
lower at follow-up (p = 0.001), and improvement was more
marked among those reporting more support (p <0.001). The
social support effect was strongest among those with high
levels of depression at baseline (p <0.001) and those with
lower income (p = 0.01). Unexpectedly, social support was
more strongly associated with improvement in younger
patients (p = 0.01). Social support did not interact with
gender, disease severity, or functional status. These
findings are partially consistent with the notion that
social support is most effective for those who are most
vulnerable and/or have few coping resources. These findings
also have implications for the design and interpretation of
psychosocial interventions.},
Doi = {10.1016/s0002-9149(00)00961-9},
Key = {fds276157}
}
@article{fds276111,
Author = {McPherson, RS and Feaganes, JR and Siegler, IC},
Title = {Measurement of dietary intake in the UNC Alumni Heart Study.
University of North Carolina.},
Journal = {Preventive Medicine},
Volume = {31},
Number = {1},
Pages = {56-67},
Year = {2000},
Month = {July},
ISSN = {0091-7435},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10896844},
Abstract = {BACKGROUND: Research needs to identify diet and disease
associations to provide direction about effecting change in
individuals with dietary behaviors that increase risk of
chronic disease. Inclusion of dietary assessment in the
University of North Carolina Alumni Heart Study (UNCAHS)
provides the opportunity to prospectively investigate
dietary intake and chronic disease associations with
measures of personality and behavioral risk factors.
METHODS: Development of the UNCAHS food frequency
questionnaire and nutrient intake of 4,443 middle-aged men
and women is provided stratified by total fat and vitamin A
intake within demographic and health behavior categories.
RESULTS: Alumni consume diets close to that recommended by
current dietary guidelines. Both men and women have low
calcium intake. Thirty-nine percent of the alumni consume
diets with 30% of kilocalories from fat or less and 88% meet
the RDA for vitamin A. Never smokers had lower fat diets and
greater intakes of vitamin A than former or current smokers.
Over 54% of alumni currently took vitamin/mineral
supplements. CONCLUSIONS: UNCAHS participants will be
tracked as they approach older ages with apparently less
risk for diet-related chronic diseases than many Americans.
The psychosocial correlates of these eating behaviors will
be evaluated as disease endpoints occur.},
Doi = {10.1006/pmed.2000.0679},
Key = {fds276111}
}
@article{fds276109,
Author = {Fredrickson, BL and Maynard, KE and Helms, MJ and Haney, TL and Siegler,
IC and Barefoot, JC},
Title = {Hostility predicts magnitude and duration of blood pressure
response to anger.},
Journal = {Journal of Behavioral Medicine},
Volume = {23},
Number = {3},
Pages = {229-243},
Year = {2000},
Month = {June},
ISSN = {0160-7715},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10863676},
Abstract = {The hypothesis that hostile and nonhostile individuals would
differ in both magnitude and duration of cardiovascular
reactivity to relived anger was tested. Participants were 66
older adults (mean age, 62; 38 women and 28 men; 70%
Caucasian American, 30% African American). Each took part in
a structured interview scored using the Interpersonal
Hostility Assessment Technique. Later each relived a
self-chosen anger memory while heart rate and systolic and
diastolic blood pressures were measured continuously using
an Ohmeda Finapres monitor. Hostile participants had larger
and longer-lasting blood pressure responses to anger.
African Americans also showed longer-lasting blood pressure
reactivity to anger. Health and measurement implications are
discussed.},
Doi = {10.1023/a:1005596208324},
Key = {fds276109}
}
@article{fds276110,
Author = {Williams, JE and Paton, CC and Siegler, IC and Eigenbrodt, ML and Nieto,
FJ and Tyroler, HA},
Title = {Anger proneness predicts coronary heart disease risk:
prospective analysis from the atherosclerosis risk in
communities (ARIC) study.},
Journal = {Circulation},
Volume = {101},
Number = {17},
Pages = {2034-2039},
Year = {2000},
Month = {May},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10790343},
Abstract = {BACKGROUND: Increased research attention is being paid to
the negative impact of anger on coronary heart disease
(CHD). METHODS AND RESULTS: This study examined
prospectively the association between trait anger and the
risk of combined CHD (acute myocardial infarction [MI]/fatal
CHD, silent MI, or cardiac revascularization procedures) and
of "hard" events (acute MI/fatal CHD). Participants were 12
986 black and white men and women enrolled in the
Atherosclerosis Risk In Communities study. In the entire
cohort, individuals with high trait anger, compared with
their low anger counterparts, were at increased risk of CHD
in both event categories. The multivariate-adjusted hazard
ratio (HR) (95% CI) was 1.54 (95% CI 1.10 to 2.16) for
combined CHD and 1.75 (95% CI 1.17 to 2.64) for "hard"
events. Heterogeneity of effect was observed by hypertensive
status. Among normotensive individuals, the risk of combined
CHD and of "hard" events increased monotonically with
increasing levels of trait anger. The multivariate-adjusted
HR of CHD for high versus low anger was 2.20 (95% CI 1.36 to
3.55) and for moderate versus low anger was 1.32 (95% CI
0.94 to 1.84). For "hard" events, the multivariate-adjusted
HRs were 2.69 (95% CI 1.48 to 4.90) and 1.35 (95% CI 0.87 to
2.10), respectively. No statistically significant
association between trait anger and incident CHD risk was
observed among hypertensive individuals. CONCLUSIONS:
Proneness to anger places normotensive middle-aged men and
women at significant risk for CHD morbidity and death
independent of the established biological risk
factors.},
Doi = {10.1161/01.cir.101.17.2034},
Key = {fds276110}
}
@article{fds276188,
Author = {Brummett, BH and Barefoot, JC and Feaganes, JR and Yen, S and Bosworth,
HB and Williams, RB and Siegler, IC},
Title = {Hostility in marital dyads: associations with depressive
symptoms.},
Journal = {Journal of Behavioral Medicine},
Volume = {23},
Number = {1},
Pages = {95-105},
Year = {2000},
Month = {February},
ISSN = {0160-7715},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10749013},
Abstract = {We examined the relations of hostility (of self and spouse)
with self-ratings of depressive symptoms in 898 spouse
pairs. Self-ratings of hostility were initially examined as
predictors of depression. Next, spouse self-ratings of
hostility were added to the model. Finally, the interaction
of self x spouse hostility was investigated. These relations
were explored for three components of hostility (Cynicism,
Aggressive Responding, and Hostile Affect). Age and
education were controlled in all models and effects were
examined separately for women and men. Self-ratings of
Hostile Affect were positively related to depressive
symptoms for both women and men. Self-ratings of Cynicism
were also significantly related to depression, but only for
men. All three components of spouse's hostility were
positively related to one's own symptoms of depression for
women. For men, however, spouse's hostility was not related
to symptoms of depression. These findings highlight the need
to study psychosocial risk factors in social units and have
potential implications for intervention.},
Doi = {10.1023/a:1005424405056},
Key = {fds276188}
}
@article{fds276186,
Author = {Clark, LM and Bosworth, HB and Welsh-Bohmer, KA and Dawson, DV and Siegler, IC},
Title = {Relation between informant-rated personality and
clinician-rated depression in patients with memory
disorders.},
Journal = {Neuropsychiatry, Neuropsychology, and Behavioral
Neurology},
Volume = {13},
Number = {1},
Pages = {39-47},
Year = {2000},
Month = {January},
ISSN = {0894-878X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10645735},
Abstract = {OBJECTIVE: The goal of this study was to examine the
convergent validity of informant-rated changes in depressive
and related personality traits with clinician-assessed
depression in memory-disordered patients. BACKGROUND:
Depressive symptoms are frequent complications in persons
with dementias such as Alzheimer disease, and caregiver
informants consistently report changes in depression and
related neurotic traits on the NEO Personality Inventory
(NEO-PI) in dementia patients. METHODS: In 78 patients
undergoing evaluation of memory complaints at an Alzheimer
disease clinic, depression was characterized by clinical
diagnosis, a clinician-rated scale, and informant ratings of
premorbid versus current depression, anxiety, vulnerability,
and neuroticism on the NEO-PI. RESULTS: The diagnostic
groups differed in meaningful patterns on the NEO-PI
measures. Those with a diagnosis of major depression
differed from never-depressed patients in all personality
areas, although those with depressed mood differed only on
NEO-PI depression. The clinician-rated depression scale
correlated modestly with current personality and change from
baseline personality. CONCLUSIONS: The NEO-PI provides a
useful measure of informants' perspectives on depressive
personality changes in patients with memory disorders but
does not correspond fully with a clinical syndrome of
depression.},
Key = {fds276186}
}
@article{fds276108,
Author = {Dawson, DV and Welsh-Bohmer, KA and Siegler, IC},
Title = {Premorbid personality predicts level of rated personality
change in patients with Alzheimer disease.},
Journal = {Alzheimer Disease and Associated Disorders},
Volume = {14},
Number = {1},
Pages = {11-19},
Year = {2000},
ISSN = {0893-0341},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10718200},
Abstract = {Multiple studies of individuals with Alzheimer disease have
substantiated significant levels of informant-rated change
in several domains and facets of the Neuroticism-Extraversion-Openness
Personality Inventory, including increases in Neuroticism
and decreases in Extraversion and Conscientiousness relative
to premorbid personality traits. Decline in Openness was
cited in some reports, and replicable changes were
identified in several facets. Current and premorbid
personality of 50 patients with Alzheimer disease were rated
by informants using the Neuroticism-Extraversion-Openness
Personality Inventory. Multiple regression analysis was used
to assess possible relationships of levels of reported
change with covariates, including premorbid rating,
education, duration of dementia, age, gender, and
Mini-Mental State Examination score. Premorbid rating was
the only significant predictor of reported change for
Neuroticism, Extraversion, Conscientiousness, and the facets
Anxiety (N1), Assertiveness (E3), and Activity (E4). Rated
change in Depression was also found to be related to
duration of dementia, change in Vulnerability was influenced
by gender, and reported change in both Openness and Ideas
showed a relationship to level of education.},
Doi = {10.1097/00002093-200001000-00002},
Key = {fds276108}
}
@article{fds276140,
Author = {Von Dras and DD and Siegler, IC and Barefoot, JC and Williams, RB and Mark,
DB},
Title = {Coronary catherization patient and wife's perceptions of
social support: effects due to characteristics of recipient,
provider, and their interaction.},
Journal = {International Journal of Aging & Human Development},
Volume = {50},
Number = {2},
Pages = {97-125},
Year = {2000},
ISSN = {0091-4150},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10791611},
Abstract = {This investigation explored relationships between coronary
catherization patient and wife's characteristics and their
perceptions of social support. Participants were 124 male
patients undergoing diagnostic catherization to detect
coronary artery disease (CAD) and their wives. Patients and
wives' mean ages were fifty-nine and fifty-six years,
respectively. While visiting the hospital both patient and
wife independently completed a brief questionnaire that
assessed psychological and physical health characteristics
and perceptions of social support. Congruent with the
interdependent and overlapping contexts, and reciprocal
relationships assumptions of Revenson's (1994)
ecological/contextual framework, results suggested
characteristics of patients and wives (e.g., age, mental
health, social functioning, hostility, depression, general
perceived health) to interactively moderate their
perceptions of social support. Overall, perceptions of
social support were found to be influenced by
characteristics of the perceiver, the support provider, and
their interaction. Concerns for supportive and helpful
caregiving are discussed.},
Doi = {10.2190/CU9W-0XKW-R4AN-G1TD},
Key = {fds276140}
}
@article{fds276158,
Author = {Barefoot, JC and Brummett, BH and Helms, MJ and Mark, DB and Siegler,
IC and Williams, RB},
Title = {Depressive symptoms and survival of patients with coronary
artery disease.},
Journal = {Psychosomatic Medicine},
Volume = {62},
Number = {6},
Pages = {790-795},
Year = {2000},
ISSN = {0033-3174},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11138998},
Abstract = {OBJECTIVE: Multiple studies have shown that high levels of
depressive symptoms increase the mortality risk of patients
with established coronary disease. This investigation
divided depressive symptoms into groups to assess their
relative effectiveness in predicting survival. METHODS:
Questionnaires about the presence of depressive symptoms
were administered to 1250 patients with significant coronary
disease while they were hospitalized for diagnostic coronary
angiography. Follow-up for mortality due to cardiac disease
was conducted annually for up to 19.4 years. Factor analysis
was used to divide items on the Zung Self-Rating Depression
Scale into four groups: Well-Being, Negative Affect,
Somatic, and Appetite. In addition, responses to a single
item regarding feelings of hopelessness were available for
920 patients. RESULTS: Well-Being and Somatic symptoms
significantly predicted survival (p < or = .01). Negative
Affect items were also related to survival (p = .0001) and
interacted with age. A 2-SD difference in the Negative
Affect term was associated with a relative risk of 1.29 for
patients >50 years old and 1.70 for younger ones. Only
Negative Affect remained significant in a model with the
other symptom groups. Hopelessness also predicted survival
with a relative risk of 1.5. Both the Hopelessness and
Negative Affect items remained as independent predictors in
the same model. All models controlled for severity of
disease and treatment. With one exception (income and
Hopelessness), results were essentially unchanged by
additional controls for age, gender, and income.
CONCLUSIONS: Depressive symptoms differentially predicted
survival, with depressive affect and hopelessness being
particularly important. These effects were independent of
disease severity and somatic symptoms and may be especially
important in younger patients.},
Doi = {10.1097/00006842-200011000-00008},
Key = {fds276158}
}
@article{fds276187,
Author = {Bosworth, HB and Siegler, IC and Olsen, MK and Brummett, BH and Barefoot, JC and Williams, RB and Clapp-Channing, NE and Mark,
DB},
Title = {Social support and quality of life in patients with coronary
artery disease.},
Journal = {Quality of Life Research},
Volume = {9},
Number = {7},
Pages = {829-839},
Year = {2000},
ISSN = {0962-9343},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11297025},
Abstract = {The relationship between perceived social support and
domain-specific health-related quality of life (HRQOL) was
examined in a sample of cardiac catheterization patients
after considering age, gender, race, education, and coronary
artery disease (CAD) severity. Data was collected on 4,278
cardiac catheterization patients (63% males) and included
1,215 patients with non-significant CAD and 3,063 patients
who had significant CAD ( > or = 75% stenosis of at least
one major coronary artery). Among the patients with
significant CAD, 2,721 were classified as low disease
severity and 342 were considered high disease severity.
Regression models indicated that a lack of social support
was associated with significantly lower levels of HRQOL
across all eight SF-36 HRQOL domains after considering
disease severity and other demographic factors. The models
also indicated that social support and other relevant
variables interacted across various HRQOL domains. Physical
function and physical role function were lower with age,
whereas mental health, emotional role function, and vitality
were higher with age. Females reported lower HRQOL than
males across all domains. Minority patients reported lower
levels of HRQOL than white patients across four domains.
Increased disease severity was related to lower levels among
four of the eight HRQOL domains. The observed interactions
of social support with minority status, disease severity,
and education suggest that a subset of individuals may
suffer lower levels of HRQOL. These individuals may
subsequently require the greatest degree of care and
potentially benefit most from intervention.},
Doi = {10.1023/a:1008960308011},
Key = {fds276187}
}
@article{fds276184,
Author = {Bosworth, HB and Siegler, IC and Brummett, BH and Barefoot, JC and Williams, RB and Clapp-Channing, NE and Mark, DB},
Title = {The association between self-rated health and mortality in a
well-characterized sample of coronary artery disease
patients.},
Journal = {Medical Care},
Volume = {37},
Number = {12},
Pages = {1226-1236},
Year = {1999},
Month = {December},
ISSN = {0025-7079},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10599604},
Abstract = {BACKGROUND: The relationship between self-rated health and
mortality after adjustment for sociodemographic variables,
physician-rated comorbidities, disease severity,
health-related quality of life (HRQOL), and psychosocial
measures (depression, social support, and functional
ability) was examined in the Mediators of Social Support
(MOSS) study. SUBJECTS: The sample consisted of 2,885
individuals (mean age, 62.5 years) who had significant heart
disease based upon heart catheterization. RESULTS. Using Cox
proportional survival analysis, individuals who rated their
health as "fair" or "poor" had a significantly greater
likelihood of all-cause mortality (OR = 2.13; CI =
1.40-3.23; OR = 4.92; CI = 3.24-7.46, respectively) across
follow-up (mean, 3.5 years) than those who rated their
health as "very good" after considering sociodemographic
factors. After adjustment for comorbidities, disease
severity, HRQOL, psychosocial factors, and demographic
variables, only those who rated their health as poor had a
significant greater risk of mortality (OR = 2.96, CI =
1.80-4.85). A similar pattern was observed for coronary
artery disease (CAD)-related mortality; increased adjustment
of variables weakened the relationship between self-rated
health and mortality. Individuals who rated their health as
poor had a significantly greater risk of CAD-related
mortality than did those who rated their health as very good
(poor vs. very good OR = 3.58, CI = 2.13-6.02) after
adjustment for all available mortality risk factors.
CONCLUSIONS: This study indicates that it is important to
include self-rated health when studying risk factors for
mortality. Not adjusting for relevant factors may provide an
overestimation of the effects of self-rated health on
mortality in a sample of CAD patients.},
Doi = {10.1097/00005650-199912000-00006},
Key = {fds276184}
}
@article{fds276241,
Author = {Vitaliano, PP and Scanlan, JM and Moe, K and Siegler, IC and Prinz, PN and Ochs, HD},
Title = {Stress, sleep problems, and immune function in persons with
cancer histories},
Journal = {Cancer Research Therapy and Control},
Volume = {10},
Number = {3},
Pages = {167-182},
Year = {1999},
Month = {December},
Abstract = {Problem. Data suggest that chronic stress, cancer history,
sleep problems and clinical depression are associated with
reduced natural killer cell activity (NKA), but few studies
have examined whether in combination these variables have
synergistic relationships with NKA. Because spouse
caregivers of persons with Alzheimer's disease are
chronically stressed, we assessed whether interactions of
caregiving, cancer history, sleep problems and clinical
depression/depressed mood would be associated with reduced
NKA in 80 spouse caregivers and 85 age- and sex- matched
non-caregiver controls. Methods. In the overall study the
mean age was 69.5 years, the percent women was 67% and the
percent Caucasian was 99%. Participants were assessed at
study entry (Time 1) and 15 - 18 months later (Time 2).
Using medical records/ICD-9 codes, we determined that
persons with a cancer history (n = 43) had not been treated
with immune altering medications for at least one year
before NKA assessments. NKA was assessed by a
chromium-release assay and all concentrations were averaged.
Results. At Times 1 and 2, direct (univariate) relationships
were weak or absent for caregiver status, cancer history,
sleep problems, and clinical depression/depressed mood. In
contrast, at both times synergistic (multivariate)
relationships occurred for NKA with the three-way
interaction of caregiver status, cancer history and sleep
problems (p < .05). Hence, caregivers with cancer histories
and sleep problems had lower NKA values (Time l, M ± SD =
22.9 ±2.8; Time 2, M= 27.7 ±4.1) than did individuals
without all three factors (Time 1, M of 7 other strata
combined = 33.1 ±1.2; Time 2, M = 33.7 ±1.1), p < .05.
Over time, sleep problems at Time 1 were predictive of
reduced NKA at Time 2 (r = -.65, p < .01), but this only
occurred in caregivers with cancer histories. Conclusions.
Synergistic effects may occur for NKA with sleep problems,
chronic stress and cancer history, independent of depressed
mood/clinical depression. © 1999 OPA (Overseas Publishers
Association) N.V. Published by license under the Harwood
Academic Publishers imprint, part of the Gordon and Breach
Publishing Group.},
Key = {fds276241}
}
@article{fds276182,
Author = {Bosworth, HB and Schaie, KW and Willis, SL and Siegler,
IC},
Title = {Age and distance to death in the Seattle Longitudinal
Study},
Journal = {Research on Aging},
Volume = {21},
Number = {6},
Pages = {723-738},
Publisher = {SAGE Publications},
Year = {1999},
Month = {November},
ISSN = {0164-0275},
url = {http://dx.doi.org/10.1177/0164027599216001},
Abstract = {A series of hierarchical regression models was used to
determine if time to death was a significant independent
variable for level and seven-year change in intellectual
performance for 1,214 community-dwelling adults. Distance to
death explained a significant amount of the variance of
intellectual performance at individuals' last measurement
but not of the decline in performance after controlling for
age, education, gender, and survivorship. The inclusion of
time to death improved the proportion of unique variance
explained by about 1% to 3% and between 4% and 10.4% of the
total variance explained. Decedents had lower levels of
verbal meaning, spatial ability, reasoning ability, and
psychomotor speed at last measurements and greater amounts
of seven-year decline on verbal meaning and psychomotor
speed. The inclusion of distance to death may help improve
the explanation of variability in performance associated
with increased age.},
Doi = {10.1177/0164027599216001},
Key = {fds276182}
}
@article{fds276183,
Author = {Bosworth, HB and Siegler, IC and Brummett, BH and Barefoot, JC and Williams, RB and Vitaliano, PP and Clapp-Channing, N and Lytle, BL and Mark, DB},
Title = {The relationship between self-rated health and health status
among coronary artery patients.},
Journal = {Journal of Aging and Health},
Volume = {11},
Number = {4},
Pages = {565-584},
Year = {1999},
Month = {November},
ISSN = {0898-2643},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10848078},
Abstract = {OBJECTIVES: This study examined the descriptive relationship
of self-rated health (SRH) with various psychosocial
measures, sociodemographic variables, coronary artery
disease (CAD) diagnostic/clinical measures, and medically
abstracted comorbidities. METHODS: The sample was 2,855
individuals from the Mediators of Social Support (MOSS)
study who had at least 75% narrowing in more than one
vessel, as indicated by a cardiac catheterization. RESULTS:
After adjusting for sociodemographic factors, individuals
who rated their health as poor/fair had significantly worse
performance on all psychosocial measures and were more
likely to be female, non-White, and of a lower socioeconomic
status than those who rated their health as being good or
better. There were few differences on SRH across various
diagnostic/clinical measures of health. DISCUSSION: A single
item measure of SRH may be useful; the generalizability of
the item must be considered. In this sample of CAD patients,
SRH was related more to psychosocial factors than to
clinical and disease indicators.},
Doi = {10.1177/089826439901100405},
Key = {fds276183}
}
@article{fds276240,
Author = {Osborn, BH and Couchman, GM and Siegler, IC and Bastian,
LA},
Title = {Osteoporosis risk factors: Association with use of hormone
replacement therapy and with worry about
osteoporosis},
Journal = {Women'S Health Issues : Official Publication of the Jacobs
Institute of Women'S Health},
Volume = {9},
Number = {6},
Pages = {278-285},
Publisher = {Elsevier BV},
Year = {1999},
Month = {November},
ISSN = {1049-3867},
url = {http://dx.doi.org/10.1016/S1049-3867(99)00017-1},
Abstract = {Objectives: To determine whether postmenopausal women with
risk factors for osteoporosis are more likely to use hormone
replacement therapy (HRT) or to worry about osteoporosis
than women without risk factors. Method: Cross-sectional
survey of postmenopausal women at the Women Veteran
Comprehensive Health Center. Statistical analysis was
performed using the chi-square test and logistic regression
analysis. Results: Of the 230 postmenopausal women who
answered the questionnaire (mean age 55.7 years), 167 (72%)
reported ever having used HRT and 113 (49%) worried about
osteoporosis. Factors that were significantly associated (P
< .05) with ever having used HRT were race, marital status,
hysterectomy, worry about osteoporosis, and being aware that
HRT reduces the risk of osteoporosis; however, no other risk
factors for osteoporosis were associated with HRT use, nor
was having the diagnosis of osteoporosis. Women who worried
about osteoporosis were significantly more likely to be
under age 60; to have a family history of osteoporosis, poor
self-rated current health, and osteoporosis as a medical
condition; to be aware that HRT reduces the risk of
osteoporosis; and to have used HRT (P < .05). Conclusions:
Among risk factors for osteoporosis, only family history was
associated with worry about osteoporosis, while white race
was the only risk factor associated with HRT use in our
cohort of postmenopausal woman veterans. This may represent
a lack of awareness and knowledge about osteoporosis and its
sequelae and about the benefits of HRT. An understanding of
patient awareness of risk factors for osteoporosis and their
motivations to take HRT can be valuable when counseling
women on their decision to use HRT or other medications to
prevent osteoporosis. Copyright (C) 1999 Elsevier Science
Inc.},
Doi = {10.1016/S1049-3867(99)00017-1},
Key = {fds276240}
}
@article{fds276206,
Author = {Barefoot, JC and Maynard, KE and Beckham, JC and Brummett, BH and Hooker, K and Siegler, IC},
Title = {Trust, health, and longevity.},
Journal = {Journal of Behavioral Medicine},
Volume = {21},
Number = {6},
Pages = {517-526},
Year = {1998},
Month = {December},
ISSN = {0160-7715},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9891252},
Abstract = {Scores on the Rotter Interpersonal Trust Scale were
evaluated as predictors of psychological well-being,
functional health, and longevity in a sample of 100 men and
women who were between 55 and 80 years old at baseline (mean
age 66.8). Cross-sectionally, high levels of trust were
associated with better self-rated health and more life
satisfaction. Follow-up over approximately 8 years found
baseline levels of trust to be positively related to
subsequent functional health, but not to subsequent life
satisfaction. Mortality follow-up after 14 years
demonstrated that those with high levels of trust had longer
survival (p = .03), a finding that was somewhat weakened by
controlling for baseline health ratings. These findings
illustrate the health protective effects of high levels of
trust and suggest the potential usefulness of the trust
concept for understanding successful aging.},
Doi = {10.1023/a:1018792528008},
Key = {fds276206}
}
@article{fds276100,
Author = {Vitaliano, PP and Scanlan, JM and Siegler, IC and McCormick, WC and Knopp, RH},
Title = {Coronary heart disease moderates the relationship of chronic
stress with the metabolic syndrome.},
Journal = {Health Psychology : Official Journal of the Division of
Health Psychology, American Psychological
Association},
Volume = {17},
Number = {6},
Pages = {520-529},
Year = {1998},
Month = {November},
ISSN = {0278-6133},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9848802},
Abstract = {Metabolic syndrome levels (MSLs) were compared in caregivers
(CGs) of spouses with Alzheimer's disease who had diagnoses
of coronary heart disease (CHD; n = 27) with non CGs with
CHD diagnoses (n = 18), and CGs (n = 44) to non CGs (n = 52)
free of CHD. MSLs were greater for CGs than non CGs, but
only in persons with CHD (CHD, B for CG status = -.41; non
CHD, B = .12; p < .05) at study entry (Time 1 = T1) and CHD,
B = -.32; non CHD, B = .14; p < .05) 15-18 months later
(Time 2 = T2). In the CHD group, MSLs were associated with
poorer health habits at T1 (r = .39, p < .01), uplifts (r =
-.37, p < .01) at T2, and CG status (p < .05) at T1 and T2.
Relationships of CG status and MSLs declined in the presence
of poor health habits at T1 and uplifts at T2. Poorer health
habits and fewer uplifts may be associated with elevated
MSLs in CGs with CHD.},
Doi = {10.1037//0278-6133.17.6.520},
Key = {fds276100}
}
@article{fds276101,
Author = {Siegler, IC and Vitaliano, PP},
Title = {Introduction to the special section: in search of a double
paradigm.},
Journal = {Health Psychology : Official Journal of the Division of
Health Psychology, American Psychological
Association},
Volume = {17},
Number = {6},
Pages = {483-485},
Year = {1998},
Month = {November},
ISSN = {0278-6133},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9848797},
Doi = {10.1037/h0092708},
Key = {fds276101}
}
@article{fds276107,
Author = {Clark, LM and McDonald, WM and Welsh-Bohmer, KA and Siegler, IC and Dawson, DV and Tupler, LA and Krishnan, KR},
Title = {Magnetic resonance imaging correlates of depression in
early- and late-onset Alzheimer's disease.},
Journal = {Biological Psychiatry},
Volume = {44},
Number = {7},
Pages = {592-599},
Year = {1998},
Month = {October},
ISSN = {0006-3223},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9787883},
Abstract = {BACKGROUND: Depressive symptoms are frequent complications
of Alzheimer's disease (AD). We hypothesized that AD
patients with depression would be more likely than
nondepressed AD patients to show deep white-matter,
subcortical gray-matter, and periventricular
hyperintensities on magnetic resonance imaging (MRI).
METHODS: In a retrospective study of 31 AD patients,
depression was characterized by clinical diagnosis
(DSM-III-R major depression, depressive symptoms, or no
depression), a clinician-rated depression scale, and
informant ratings of premorbid (before memory disorder) as
well as current depression using the NEO Personality
Inventory (NEO-PI), and related to qualitative and
quantitative ratings of MRI hyperintensities. RESULTS: In
contrast to reports in nondemented elderly patients, there
was no relationship between clinical diagnosis of major
depressive episode and hyperintensities; however,
clinician-rated depressive symptoms were higher in subjects
with large anterior hyperintensities. In the early-onset AD
group only, MRI abnormalities were related to greater
premorbid depression, and less increase in depression after
the onset of dementia, as rated by informants on the NEO-PI.
CONCLUSIONS: Results highlight the need to consider early-
and late-onset AD separately when assessing relationships
between personality and MRI abnormalities, and to consider
premorbid personality style when drawing conclusions about
the etiology of depressive features seen in
AD.},
Doi = {10.1016/s0006-3223(98)00106-1},
Key = {fds276107}
}
@article{fds276106,
Author = {Exline, JL and Siegler, IC and Bastian, LA},
Title = {Differences in providers' beliefs about benefits and risks
of hormone replacement therapy in managed
care.},
Journal = {Journal of Women'S Health},
Volume = {7},
Number = {7},
Pages = {879-884},
Year = {1998},
Month = {September},
ISSN = {1059-7115},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9785314},
Abstract = {Our objective was to determine if physician beliefs about
the benefits and risks of hormone replacement therapy (HRT)
differ by physician gender or specialty in a managed care
setting. In a cross-sectional survey of providers in a
health maintenance organization in North Carolina, 105
gynecologists, internists, and family physicians and
physician assistants were surveyed, and 74 providers
completed and returned the survey (70.5% response rate).
Providers' beliefs about the benefits and risks of HRT
differed by specialty and gender of physician. Gynecologists
are significantly less concerned about the potential risks
of HRT on breast cancer (p = 0.004) and thromboembolic
events (p = 0.005) compared with family physicians and
internists. Female providers across the three specialty
categories were significantly different from their male
colleagues in their beliefs about the benefits of HRT with
regard to the reduction in risk of heart disease (79% versus
64%, p = 0.001), osteoporosis (83% versus 75%, p = 0.045),
and Alzheimer's disease (45% versus 26%, p = 0.026). There
was a trend toward female physicians being more convinced
about the risks of breast cancer than their male colleagues
(p = 0.08). Our results suggest that providers in a managed
care setting vary in their beliefs about the benefits and
risks of HRT, and this may affect provider-patient
discussions about HRT.},
Doi = {10.1089/jwh.1998.7.879},
Key = {fds276106}
}
@article{fds276103,
Author = {Barefoot, JC and Heitmann, BL and Helms, MJ and Williams, RB and Surwit,
RS and Siegler, IC},
Title = {Symptoms of depression and changes in body weight from
adolescence to mid-life.},
Journal = {Int J Obes Relat Metab Disord},
Volume = {22},
Number = {7},
Pages = {688-694},
Year = {1998},
Month = {July},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9705031},
Abstract = {OBJECTIVE: To investigate the relationship of symptoms of
depression to weight changes in healthy individuals of
normal weight across a follow-up of over 20 y. PARTICIPANTS
AND DESIGN: College students (3885 men and 841 women) were
administered a self-report depression measure in the
mid-1960s. Their baseline body mass index (BMI) was
calculated from their college medical records. Participants
were contacted by mail in the late 1980s and asked to report
their current height and weight as well as their smoking and
exercise habits. Another measure of depressive symptoms was
obtained from 3560 individuals at follow-up. Multiple
regression models were used to relate changes in weight to
depression scores while controlling for background (gender,
baseline BMI and the gender by BMI interaction) and
behavioral (exercise and smoking) predictors. RESULTS: The
relationship between depressive symptoms and body weight
change took the form of an interaction with baseline BMI (P
< 0.001). Those with high baseline depression scores gained
less weight than their nondepressed counterparts if they
were initially lean, but more if they were initially heavy.
This trend was especially strong in those with high
depression scores at both baseline and follow-up.
CONCLUSIONS: The findings support the hypothesis that
depression exaggerates pre-existing weight change
tendencies. This pattern would not have been detected by an
examination of main effects alone, illustrating the need to
move toward more complicated interactive models in the study
of psychological factors and weight.},
Doi = {10.1038/sj.ijo.0800647},
Key = {fds276103}
}
@article{fds276102,
Author = {Bastian, L and Couchman, G and Rimer, BK and McBride, CM and Sutton, L and Siegler, IC},
Title = {Promoting informed decision making: hormone replacement
therapy.},
Journal = {Cancer Treatment and Research},
Volume = {97},
Pages = {129-147},
Year = {1998},
ISSN = {0927-3042},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9711414},
Doi = {10.1007/978-0-585-30498-4_10},
Key = {fds276102}
}
@article{fds276104,
Author = {Vitaliano, PP and Scanlan, JM and Ochs, HD and Syrjala, K and Siegler,
IC and Snyder, EA},
Title = {Psychosocial stress moderates the relationship of cancer
history with natural killer cell activity.},
Journal = {Annals of Behavioral Medicine},
Volume = {20},
Number = {3},
Pages = {199-208},
Year = {1998},
ISSN = {0883-6612},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9989327},
Abstract = {Data suggest that both cancer history and psychosocial
stress may be associated with reductions in natural killer
cell activity (NKA). Therefore, we tested whether individual
differences in cancer history, chronic/perceived stress, and
their interactions would be associated with decreased levels
of NKA. We tested these hypotheses in 80 spouse caregivers
of victims of Alzheimer's Disease (AD) (persons known to
report high levels of psychosocial stress) and in 85 age-
and sex-matched spouses of non-demented controls.
Participants were assessed at study entry (Time 1) and 15-18
months later (Time 2). Individuals with cancer histories (N
= 43) had not been treated with immune altering medications
within the last year. At both Times 1 and 2, cross-sectional
main effects were weak or absent for cancer history,
perceived stress (e.g. high hassles, low uplifts), and
caregiver status; however, interactions occurred between
cancer history and perceived stress, such that persons with
cancer histories and high hassles/low uplifts had the lowest
NKA values (p < .05). These results occurred even after
controlling for age, gender, beta-blocker use, hormone
replacement therapy, alcohol, and exercise. At Time 1, an
interaction also occurred between caregiver status and
cancer history--caregivers with cancer histories had lower
NKA than did controls with cancer histories and
caregivers/controls without cancer histories (p < .05). At
Time 2, this interaction only showed a trend (p < .08),
primarily because caregivers with cancer histories
experienced increases in NKA (p < .05) from Time 1 to Time
2, whereas in the other three groups NKA did not change.
Importantly, in caregivers with cancer histories, high
perceived stress at Time 1 predicted low NKA at Time 2 (p <
.05). This research suggests that the combinations of
biological vulnerabilities and chronic/perceived stress may
have interactive effects resulting in reduced
NKA.},
Doi = {10.1007/BF02884961},
Key = {fds276104}
}
@article{fds276181,
Author = {Bosworth, HB and Bastian, LA and Siegler, IC},
Title = {Benefits and drawbacks to hormone replacement therapy among
nursing home patients.},
Journal = {Women'S Health Issues : Official Publication of the Jacobs
Institute of Women'S Health},
Volume = {8},
Number = {1},
Pages = {53-59},
Year = {1998},
ISSN = {1049-3867},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9504039},
Doi = {10.1016/s1049-3867(97)00094-7},
Key = {fds276181}
}
@article{fds276208,
Author = {Brummett, BH and Maynard, KE and Babyak, MA and Haney, TL and Siegler,
IC and Helms, MJ and Barefoot, JC},
Title = {Measures of hostility as predictors of facial affect during
social interaction: evidence for construct
validity.},
Journal = {Annals of Behavioral Medicine},
Volume = {20},
Number = {3},
Pages = {168-173},
Year = {1998},
ISSN = {0883-6612},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9989323},
Abstract = {We assessed the construct validity of several self-report
measures and an interview-based measure of hostility
(Interpersonal Hostility Assessment Technique [IHAT]) by
evaluating their associations with a behavioral indicator of
hostile emotions (facial expressions during social
interaction). Participants in the study were 123 volunteers
(44% males and 56% females) who were recruited from local
community organizations. Self-report measures (Cook-Medley
Hostility Scale, Rotter Interpersonal Trust Scale,
Buss-Durkee Hostility Inventory, and Spielberger Anger
Expression Scale) were represented by factor scores
reflecting Overt Hostility, Covert Hostility, and Hostile
Beliefs. A canonical correlation analysis identified
significant associations between a set of facial affect
scores reflecting animosity and various measures of
hostility. Specifically, increases in anger and disgust
expressions and decreases in happy facial expressions were
associated with high IHAT scores and high scores on
self-report measures of Hostile Beliefs and Covert
Hostility. Women were more expressive than men, especially
concerning positive affect, and women had lower scores on
self-report measures of Hostile Beliefs and Overt Hostility.
IHAT scores were uncorrelated with any of the self-report
factors which suggests the two assessment techniques are
tapping different aspects of the hostility
construct.},
Doi = {10.1007/BF02884957},
Key = {fds276208}
}
@article{fds276209,
Author = {Brummett, BH and Babyak, MA and Barefoot, JC and Bosworth, HB and Clapp-Channing, NE and Siegler, IC and Williams, RB and Mark,
DB},
Title = {Social support and hostility as predictors of depressive
symptoms in cardiac patients one month after
hospitalization: a prospective study.},
Journal = {Psychosomatic Medicine},
Volume = {60},
Number = {6},
Pages = {707-713},
Year = {1998},
ISSN = {0033-3174},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9847029},
Abstract = {OBJECTIVE: Hospitalization for cardiac disease is associated
with an increased risk for depression, which itself confers
a poorer prognosis. Few prospective studies have examined
the determinants of depression after hospitalization in
cardiac patients, and even fewer have examined depression
within the weeks after hospital discharge. The present study
assessed the prospective relations among perceptions of
social support and trait hostility in predicting symptoms of
depressive symptoms at 1 month after hospitalization for a
diagnostic angiography in 506 coronary artery disease (CAD)
patients. METHOD: A series of structural equation models 1)
estimated the predictive relations of social support,
hostility, and depressive symptoms while in the hospital to
symptoms of depression 1 month after hospitalization, and 2)
compared these relations across gender, predicted risk
classification, and age. RESULTS: Social support assessed
during hospitalization was independently negatively
associated with depressive symptoms 1 month after
hospitalization, after controlling for baseline symptoms of
depression, gender, disease severity, and age. Hostility was
an indirect predictor of postdischarge depressive
symptomology by way of its negative relation with social
support. This pattern of relations did not differ across
gender, predicted risk classification, and age. CONCLUSIONS:
Our findings suggest that a patient's perceived social
support during hospitalization is a determinant of
depressive symptoms 1 month later. The relation of social
support and hostility to subsequent depressive symptoms was
similar across a variety of populations.},
Doi = {10.1097/00006842-199811000-00008},
Key = {fds276209}
}
@article{fds276099,
Author = {Bastian, LA and Couchman, GM and Rimer, BK and McBride, CM and Feaganes,
JR and Siegler, IC},
Title = {Perceptions of menopausal stage and patterns of hormone
replacement therapy use.},
Journal = {Journal of Women'S Health},
Volume = {6},
Number = {4},
Pages = {467-475},
Year = {1997},
Month = {August},
ISSN = {1059-7115},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9279835},
Abstract = {In 1994, as part of their participation in the University of
North Carolina Alumni Heart Study, 1101 women aged 45-51
years answered questions about their menopausal status and
current use of hormone replacement therapy (HRT). Little is
known about the use of HRT in younger women. We were
interested in determining both patterns of HRT use and
patient characteristics associated with HRT use in this
cohort of women approaching the average age of menopause.
After excluding women with breast, endometrial, and ovarian
cancer, we studied 1080 women. These women identified
themselves as: "There is no indication that I am near
menopause" (stage 1, n = 326), "I think I may be close to or
in the beginning stages of menopause but am not sure" (stage
2, n = 410), "I have begun menopause" (stage 3, n = 202),
and "I have been through menopause" (stage 4, n = 142). The
overall rate of HRT use was 22% (0% in stage 1, 8% in stage
2, 52% in stage 3, and 76% in stage 4). Both patterns of HRT
use and patient characteristics associated with HRT use
differed based on the woman's perception of her menopausal
stage. In logistic regression models, where HRT use was the
outcome variable, independent predictors of HRT use included
stage of menopause, having had a hysterectomy, having had a
bilateral oophorectomy, no family history of breast cancer,
having had a pelvic examination in the last year, being
married, and not participating regularly in physical
exercise. A woman's perception of her stage in the process
of reproductive aging correlates with her use of HRT.
Informed decision making about HRT use should be tailored to
the individual's perception of her menopausal
stage.},
Doi = {10.1089/jwh.1997.6.467},
Key = {fds276099}
}
@article{fds276203,
Author = {Williams, RB and Barefoot, JC and Blumenthal, JA and Helms, MJ and Luecken, L and Pieper, CF and Siegler, IC and Suarez,
EC},
Title = {Psychosocial correlates of job strain in a sample of working
women.},
Journal = {Archives of General Psychiatry},
Volume = {54},
Number = {6},
Pages = {543-548},
Year = {1997},
Month = {June},
ISSN = {0003-990X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9193195},
Abstract = {BACKGROUND: This study identifies potential mediators of job
strain effects on health by determining whether psychosocial
factors known to predict an increased risk of cardiovascular
disease and all-cause mortality are higher among women who
report high levels of job strain. METHODS: Measures of job
strain and other psychosocial risk factors were obtained in
a sample of 152 female employees of a local corporation.
Canonical correlation and analyses of covariance were used
to assess relationships between job demands and decision
latitude and other psychosocial risk factors. RESULTS: A
significant (P = .002) solution to the canonical correlation
analysis showed that high job demands and low decision
latitude were correlated with a pattern of psychosocial
factors consisting of (1) increased levels of negative
emotions like anxiety, anger, depression, and hostility; (2)
reduced levels of social support; and (3) a preponderance of
negative compared with positive feelings in dealings with
coworkers and supervisors. This pattern was confirmed by
analyses of covariance that adjusted for demographic and
specific job characteristics. CONCLUSIONS: The canonical
correlation analysis results provide empirical support for
the job strain construct. The most important finding is that
health-damaging psychosocial factors like job strain,
depression, hostility, anxiety, and social isolation tend to
cluster in certain individuals.},
Doi = {10.1001/archpsyc.1997.01830180061007},
Key = {fds276203}
}
@article{fds276139,
Author = {Von Dras and DD and Siegler, IC and Williams, RB and Clapp-Channing, N and Haney, TL and Mark, DB},
Title = {Surrogate assessment of coronary artery disease patients'
functional capacity.},
Journal = {Social Science & Medicine},
Volume = {44},
Number = {10},
Pages = {1491-1502},
Year = {1997},
Month = {May},
ISSN = {0277-9536},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9160439},
Abstract = {An investigation of the surrogate assessment of coronary
artery disease (CAD) patients' functional capacity was
conducted using 193 patient and surrogate rater dyads. Mean
age of patients and surrogate raters were 60.4 and 54.4
years, respectively. Patients and surrogates independently
completed a brief questionnaire that assessed health and
psychosocial factors. The Duke Activity Status Index (DASI)
was contained in the patients' questionnaire, while a
similar form modified to assess patients' functional
capacity was imbedded in the surrogates' questionnaire.
Results indicated similar psychometric characteristics and
clinical validity for patients' self-report and surrogates'
ratings, suggesting that the Surrogate Rating Form of the
Duke Activity Status Index (DASI-SRF) is a reliable and
valid proxy method of assessing patient's functional
capacity when this information may not be obtained directly
from the patient. Further, while there were no effects of
surrogates' health and psychological characteristics on
their ratings of patients' functional capacity, in
comparison with other surrogates, spouses were more likely
to rate patients higher in functional capacity. Exploration
of the patient/care provider relationship via concurrent use
of the DASI and DASI-SRF is discussed.},
Doi = {10.1016/s0277-9536(96)00269-9},
Key = {fds276139}
}
@article{fds276098,
Author = {Von Dras and DD and Siegler, IC},
Title = {Stability in extraversion and aspects of social support at
midlife.},
Journal = {Journal of Personality and Social Psychology},
Volume = {72},
Number = {1},
Pages = {233-241},
Year = {1997},
Month = {January},
ISSN = {0022-3514},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9008383},
Abstract = {This investigation used participants from the University of
North Carolina Alumni Heart Study in an exploration of
extraversion and aspects of social support at midlife.
Results indicated that extraversion measured at college
entry and at midlife was positively correlated with social
activity and perceived social support measured later in
middle adulthood. Multiple regression correlational analyses
suggested that both the stable and changing components of
extraversion influence structural and functional aspects of
social support. Further, the changing component of
extraversion was found to be significantly associated with
greater social activity, perceived social support, and an
increased likelihood of seeking support when faced with a
stressful problem in middle adulthood. Overall, the
development of sociability and outgoingness in interpersonal
relationships during adolescence and young adulthood is
suggested to be an important antecedent of the structural
characteristics and functional dynamics of social support at
midlife.},
Doi = {10.1037//0022-3514.72.1.233},
Key = {fds276098}
}
@article{fds276202,
Author = {Szczepanski, R and Napolitano, M and Feaganes, JR and Barefoot, JC and Luecken, L and Swoap, RS and Kuhn, C and Suarez, E and Siegler, IC and Williams, RB and Blumenthal, JA},
Title = {Relation of mood ratings and neurohormonal responses during
daily life in employed women.},
Journal = {International Journal of Behavioral Medicine},
Volume = {4},
Number = {1},
Pages = {1-16},
Year = {1997},
ISSN = {1070-5503},
url = {http://www.ncbi.nlm.nih.gov/pubmed/16250739},
Abstract = {Diurnal variations in urinary norepinephrine, epinephrine,
cortisol, and self-reported mood states were examined in 101
employed women. Urine was collected on 2 consecutive
workdays at 3 time periods: (1) overnight, (2) daytime, and
(3) evening. Self-reports of 14 mood states were combined to
correspond with the urinary collection periods. Factor
analyses revealed 3 mood factors: Pressured (rushed, busy,
stressed, hassled, and tense), Distressed (afraid,
depressed, bored, and nervous), and Contented (satisfied,
thoughtful, excited, and calm). The Distressed factor was
significantly associated with norepinephrine excretion (p
<.001). The Pressured factor was significantly associated
with cortisol, epinephrine, and norepinephrine excretion (p
<.001) independent of age, ethnicity, marital status,
parental status, department within the company and activity
level. Secretion of urinary hormones and the Pressured
factor followed the same diurnal pattern. Specifically, as
women's self-ratings of feeling pressured initially
increased and then decreased over the course of the workday,
urinary hormones also peaked and then dropped. Once time of
day was statistically controlled, however, the mood factors
were no longer significantly related to the urinary
hormones.},
Doi = {10.1207/s15327558ijbm0401_1},
Key = {fds276202}
}
@article{fds276204,
Author = {Luecken, LJ and Suarez, EC and Kuhn, CM and Barefoot, JC and Blumenthal,
JA and Siegler, IC and Williams, RB},
Title = {Stress in employed women: impact of marital status and
children at home on neurohormone output and home
strain.},
Journal = {Psychosomatic Medicine},
Volume = {59},
Number = {4},
Pages = {352-359},
Year = {1997},
ISSN = {0033-3174},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9251153},
Abstract = {OBJECTIVE: To evaluate the biological and psychological
effects of role overload, we examined the effects of marital
(or partnership) status and parental status (defined as
having children at home) on daily excretion of urinary
catecholamines and cortisol in a sample of 109 employed
women. Other measures included work and home strain, and
social support. METHODS: Urine collection was conducted on
two consecutive workdays in three separate aliquots, a)
overnight, b) daytime, and c) evening. Repeated-measures
analysis of covariance with age and caffeine consumption as
covariates was conducted on levels of epinephrine,
norepinephrine, and cortisol in the three aliquots averaged
across the 2 days. RESULTS: We found a significant main
effect of parental status on 24-hour cortisol excretion, (p
< .01) such that women with at least one child living at
home excreted significantly more cortisol, independent of
marital status or social support. Women with children at
home also reported higher home strain (p < .001) but not
work strain. A significant period of day effect for
catecholamine levels was found (norepinephrine, p < .001;
epinephrine, p < .0001) with all subjects showing an
increase during the workday and little or no decline in
levels during the evening. Catecholamine levels were
unrelated to marital status, parental status, or social
support. CONCLUSIONS: These findings indicate that working
women with children at home, independent of marital status
or social support, excrete greater amounts of cortisol and
experience higher levels of home strain than those without
children at home.},
Doi = {10.1097/00006842-199707000-00003},
Key = {fds276204}
}
@article{fds276201,
Author = {Barefoot, JC and Helms, MJ and Mark, DB and Blumenthal, JA and Califf,
RM and Haney, TL and O'Connor, CM and Siegler, IC and Williams,
RB},
Title = {Depression and long-term mortality risk in patients with
coronary artery disease.},
Journal = {The American Journal of Cardiology},
Volume = {78},
Number = {6},
Pages = {613-617},
Year = {1996},
Month = {September},
ISSN = {0002-9149},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8831391},
Abstract = {Previous research has established that patients with
coronary artery disease (CAD) have an increased risk of
death if they are depressed at the time of hospitalization.
Follow-up periods have been short in these studies;
therefore, the present investigation examined this
phenomenon over an extended period of time. Patients with
established CAD (n = 1,250) were assessed for depression
with the Zung Self-Rating Depression Scale (SDS) and
followed for subsequent mortality. Follow-up ranged up to
19.4 years. SDS scores were associated with increased risk
of subsequent cardiac death (p = 0.002) and total mortality
(p < 0.001) after controlling for initial disease severity
and treatment. Patients with moderate to severe depression
had a 69% greater odds of cardiac death and a 78% greater
odds of mortality from all causes than nondepressed
patients. Increased risk was not confined to the initial
months after hospitalization. Patients with high SDS scores
at baseline still had a higher risk of cardiac death > 5
years later (p < 0.005). Compared with the nondepressed,
patients with moderate to severe depression had an 84%
greater risk 5 to 10 years later and a 72% greater risk
after > 10 years. Patients with mild depression had
intermediate levels of risk in all models. The heightened
long-term risk of depressed patients suggests that
depression may be persistent or frequently recurrent in CAD
patients and is associated with CAD progression, triggering
of acute events, or both.},
Doi = {10.1016/s0002-9149(96)00380-3},
Key = {fds276201}
}
@article{fds276151,
Author = {Hughes, DC and Fillenbaum, GG and Woodbury, MA and Siegler,
IC},
Title = {Psychometric characteristics of the Mini-Mental State
Examination in a community population - A grade of
membership analysis: Part I},
Journal = {International Journal of Geriatric Psychiatry},
Volume = {11},
Number = {5},
Pages = {439-455},
Publisher = {WILEY},
Year = {1996},
Month = {May},
ISSN = {0885-6230},
url = {http://dx.doi.org/10.1002/(SICI)1099-1166(199605)11:5<439::AID-GPS334>3.0.CO;2},
Abstract = {The Mini-Mental State Examination (MMSE), a brief, widely
used measure of cognitive status, was designed to assess
functioning in five areas (orientation, registration,
attention and calculation, recall and language). Using a
grade of membership analysis, which does not rely on a
multivariate normal distribution or assume an underlying
continuum for dichotomously scored variables, we examined
data from a sample of 1317 community residents 18 years of
age and older who made two or more errors on the MMSE. Our
findings suggest that for these primarily cognitively intact
persons, the items of the MMSE varied in level of
difficulty; multiple distinct areas of cognitive functioning
were not identified. The results of confirmatory testing
using clinic populations with cognitive deficit are given in
the accompanying article.},
Doi = {10.1002/(SICI)1099-1166(199605)11:5<439::AID-GPS334>3.0.CO;2},
Key = {fds276151}
}
@article{fds276096,
Author = {Siegler, IC and Feaganes, JR and Rimer, BK},
Title = {Awareness of and responses to changes in the National Cancer
Institute's guidelines for mammography in women aged
35-49},
Journal = {Journal of Women'S Health},
Volume = {5},
Number = {1},
Pages = {33-41},
Publisher = {MARY ANN LIEBERT, INC},
Year = {1996},
Month = {January},
url = {http://dx.doi.org/10.1089/jwh.1996.5.33},
Abstract = {In 1994, as part of their participation in the University of
North Carolina UNC Alumni Heart Study (UNCAHS), 1134 women
aged 35-49 years answered five questions designed to assess
the impact of the National Cancer Institute's (NCI) changing
recommendations about screening mammography for women aged
40-49. The popular press and media frequently covered this
topic in November and December 1993. The majority of the
women had heard of the NCI's changed recommendations (84%).
The main sources of information were newspapers (72%) and
radio/TV (70%). Of the 84% of the women who had heard of the
recommended changes, 27% reported an intention to reduce
their frequency of mammography and 73% reported no changes
in their planned behavior. Knowledge of the recommended
changes was associated with personality factors, self-rated
health, and income, whereas intention to change behavior was
associated with the individual's risk of breast cancer and
level of achievement striving. The results indicate that
women's responses to important health information can be
predicted by their personality. Increased hostility,
neuroticism, depression, impulsiveness, and vulnerability
lead to a reduced likelihood of awareness of changes in the
recommendations, and increased extraversion-activity,
openness to ideas, competence, and self-discipline lead to
an increased likelihood of being aware of the changes in
guidelines. The effects of neuroticism, vulnerability, and
depression on awareness of changes in NCI guidelines are
independent of the effect of sufficiency of income and
self-rated health. However, the effects of hostility,
impulsiveness, extraversion-activity, openness to ideas,
competence, and self-discipline are mediated by the effects
of sufficiency of income and self-rated health. Among women
who noted the changes in the recommendations, decisions
among this well-educated group of women were predicted by
their personal risk of breast cancer. In addition, those
higher in achievement striving were less likely to change
their intention to have regular mammograms.},
Doi = {10.1089/jwh.1996.5.33},
Key = {fds276096}
}
@article{fds276146,
Author = {Lipkus, IM and Dalbert, C and Siegler, IC},
Title = {The importance of distinguishing the belief in a just world
for self versus for others: Implications for psychological
well-being},
Journal = {Personality & Social Psychology Bulletin},
Volume = {22},
Number = {7},
Pages = {666-677},
Publisher = {SAGE Publications},
Year = {1996},
Month = {January},
url = {http://dx.doi.org/10.1177/0146167296227002},
Abstract = {Studies have shown that the belief in a just world (BJW) is
related to psychological well-being. The authors suggest
that studies exploring this relationship might benefit by
making the distinction between the BJW for self versus for
others or in general. In two studies, the authors assessed
subjects' perceptions of depression, stress, and life
satisfaction for self and for others. Subjects also
completed measures of the five-factor model of personality.
As predicted, the BJW for self most strongly and
consistently predicted decreases in depression and stress,
and increases in life satisfaction. When the five
personality dimensions were included in the analyses, the
BJW for self and for others continued to predict life
satisfaction but not depression and stress. The implications
of these results concerning the relationship between the BJW
and psychological well-being, and how the just world is
conceptualized, are discussed.},
Doi = {10.1177/0146167296227002},
Key = {fds276146}
}
@article{fds276095,
Author = {Von Dras and DD and Williams, RB and Kaplan, BH and Siegler,
IC},
Title = {Correlates of perceived social support and equality of
interpersonal relationships at mid-life.},
Journal = {International Journal of Aging & Human Development},
Volume = {43},
Number = {3},
Pages = {199-217},
Year = {1996},
ISSN = {0091-4150},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9031005},
Abstract = {An investigation into the correlates of perceived social
support and the equality of interpersonal relationships at
mid-life was conducted using a sample of 3954 adults from
the University of North Carolina Alumni Heart Study
(UNCAHS). Participants ranged in age from forty to fifty
years. Results suggested that while the number of family
roles and social activities are the same for men and women,
women perceive a greater availability of social support and
report they give more than they take in relationships with
family. There was no association found between the perceived
availability of social support and global indices of
equality of interpersonal relationships; suggesting an
independence between these two psychological aspects of
social support. Further, multiple regression correlational
analyses indicated gender, level of social activity, and
self-esteem as significant predictors of perceived social
support; with self-esteem being the best single predictor.
Relatedly, gender and number of children were found to be
significant predictors of the perceived equality of
relationships with family. These findings suggest
differences in mid-life men and women's psychological
perception of the availability of social support, and the
give and take of relationships with family.},
Doi = {10.2190/M0GP-7R75-AQJ6-Q17H},
Key = {fds276095}
}
@article{fds276097,
Author = {Morton, E and Tambor, E and Rimer, BK and Tessaro, I and Farrell, D and Siegler, IC},
Title = {Impact of National Cancer Institute revised mammography
screening guidelines on women 40-49.},
Journal = {Women'S Health Issues : Official Publication of the Jacobs
Institute of Women'S Health},
Volume = {6},
Number = {5},
Pages = {246-254},
Year = {1996},
ISSN = {1049-3867},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8870503},
Doi = {10.1016/1049-3867(96)00036-9},
Key = {fds276097}
}
@article{fds324824,
Author = {Dawson, DV and Siegler, IC},
Title = {Approaches to the nonparametric analysis of limited
longitudinal data sets.},
Journal = {Experimental Aging Research},
Volume = {22},
Number = {1},
Pages = {33-57},
Year = {1996},
url = {http://dx.doi.org/10.1080/03610739608253996},
Abstract = {The traditional goals of longitudinal studies are many:
consideration of stability and change; description of
patterns of development and behavior; and understanding of
the processes involved in disease, including disease onset,
recovery, response to treatment, natural history of the
aging process, and identification of factors that predict
age-related outcomes. Researchers in aging seek to unravel
the impact and interaction of physical and psychological
processes on human development, health, and disease. From
the point of view of statistical analysis, the critical
aspect of data obtained from longitudinal studies is the
inherent correlational structure of multiple measurements
made on a single subject or other experimental unit, which
must be appropriately treated in the analysis of the data.
We discuss a series of nonparametric approaches that are
both analytically accessible and particularly well suited to
the analysis of sparse or otherwise limited longitudinal
data.},
Doi = {10.1080/03610739608253996},
Key = {fds324824}
}
@article{fds276145,
Author = {Lipkus, IM and Siegler, IC},
Title = {Do comparative self-appraisals during young adulthood
predict adult personality?},
Journal = {Psychology and Aging},
Volume = {10},
Number = {2},
Pages = {229-237},
Year = {1995},
Month = {June},
ISSN = {0882-7974},
url = {http://www.ncbi.nlm.nih.gov/pubmed/7662182},
Abstract = {Archival data from the University of North Carolina Alumni
Heart Study were used to assess whether positive, neutral,
and negative social comparisons assessed during college
predicted the expression of personality during adulthood.
College students in 1966 rated themselves relative to peers
on several personal attributes. For men and women, these
attributes produced 3 similar yet distinct variables
reflecting gregariousness, achievement striving, and
expressiveness. These students were contacted 20 years later
and completed the NEO Personality Inventory and M.
Rosenberg's (1965) self-esteem measure. In general, persons
with comparatively positive self-evaluations during college
viewed themselves as possessing more positive and less
negative personality traits during adulthood and were also
less likely to report poorer self-esteem during middle
adulthood. The implications of social comparison processes
for personality development are discussed.},
Doi = {10.1037//0882-7974.10.2.229},
Key = {fds276145}
}
@article{fds276250,
Author = {Siegler, IC and Feaganes, JR and Rimer, BK},
Title = {Predictors of adoption of mammography in women under age
50.},
Journal = {Health Psychology : Official Journal of the Division of
Health Psychology, American Psychological
Association},
Volume = {14},
Number = {3},
Pages = {274-278},
Year = {1995},
Month = {May},
ISSN = {0278-6133},
url = {http://www.ncbi.nlm.nih.gov/pubmed/7641669},
Abstract = {Women in the University of North Carolina Alumni Heart Study
reported their knowledge of and attitudes toward mammography
as well as their adoption of mammography by 1991.
Personality measured in 1988-1989 at the age of 42 was
associated with the pattern of adoption of mammography
reported 2 years later. Adoption of regular mammograms was
predicted by conscientiousness, extraversion, and lower
depression but not by anxiety. After adjusting for 8
traditional predictors of mammography shown to be
significant in this population, the previous personality
factors did not maintain their significance. When the women
were divided into those who reported breast problems and
those who did not, the same set of adjustment factors
reduced, but did not eliminate, the association of
conscientiousness with adoption of mammography for women
without breast problems.},
Doi = {10.1037//0278-6133.14.3.274},
Key = {fds276250}
}
@article{fds276094,
Author = {Siegler, IC and Costa, PT},
Title = {Personality and breast cancer screening behaviors},
Journal = {Annals of Behavioral Medicine},
Volume = {16},
Number = {4},
Pages = {347-351},
Year = {1994},
Month = {December},
Abstract = {This review examines findings on the relationship between
personality and breast cancer screening behaviors. Because
the literature is limited, data from the University of North
Carolina Alumni Heart Study (UNCAHS) are presented showing
the associations between personality measured by the NEO
Personality Inventory (NEO-PI) and mammography and breast
self-examination.},
Key = {fds276094}
}
@article{fds276251,
Author = {Siegler, IC and Dawson, DV and Welsh, KA},
Title = {Caregiver ratings of personality change in Alzheimer's
disease patients: a replication.},
Journal = {Psychology and Aging},
Volume = {9},
Number = {3},
Pages = {464-466},
Year = {1994},
Month = {September},
ISSN = {0882-7974},
url = {http://www.ncbi.nlm.nih.gov/pubmed/7999331},
Abstract = {Caregivers of 26 patients with Alzheimer's disease (AD)
rated current and premorbid personality patterns with the
NEO Personality Inventory. Results replicated previous
findings on the degree of change reported in a previous
group of patients with mixed memory disorder diagnoses.
After a diagnosis of AD, the patients were rated as
significantly more neurotic, less extraverted, less open,
and less conscientious. There were no rated differences of
changes in the personality domain of Agreeableness. These
results strengthen the usefulness of caregiver ratings of
personality change of patients with memory problems who
cannot be useful informants on their own
behalf.},
Doi = {10.1037//0882-7974.9.3.464},
Key = {fds276251}
}
@article{fds276144,
Author = {Lipkus, IM and Barefoot, JC and Feaganes, J and Williams, RB and Siegler, IC},
Title = {A short MMPI scale to identify people likely to begin
smoking.},
Journal = {Journal of Personality Assessment},
Volume = {62},
Number = {2},
Pages = {213-222},
Year = {1994},
Month = {April},
ISSN = {0022-3891},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8189332},
Abstract = {An item analysis of the Minnesota Multiphasic Personality
Inventory (MMPI) was conducted to develop questionnaires
that best discriminated (a) individuals who ever smoked
versus those who never smoked and (b) ex-smokers from
current smokers. The analyses were based on a sample of
subjects who took the MMPI during 1964-1967 and reported
their smoking status during 1987. Although no items
distinguished individuals who quit versus continued to
smoke, several items discriminated people who ever smoked
from nonsmokers. These items formed two factors:
Extraversion and Unconventionalism. These results provide
support for the importance of extraversion, impulsivity, and
antisocial tendencies as personality predictors of smoking
initiation. The utility of this MMPI scale is
discussed.},
Doi = {10.1207/s15327752jpa6202_4},
Key = {fds276144}
}
@article{fds276143,
Author = {Lipkus, IM and Barefoot, JC and Williams, RB and Siegler,
IC},
Title = {Personality measures as predictors of smoking initiation and
cessation in the UNC Alumni Heart Study.},
Journal = {Health Psychology : Official Journal of the Division of
Health Psychology, American Psychological
Association},
Volume = {13},
Number = {2},
Pages = {149-155},
Year = {1994},
Month = {March},
ISSN = {0278-6133},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8020458},
Abstract = {MMPI data collected from a sample of college men and women
during 1964-1967 were used to predict smoking initiation and
cessation over a 20-year follow-up period. People who
subsequently began smoking were more rebellious, impulsive,
sensation seeking, and hostile; were less likely to present
a positive self-image; and were socially extraverted while
in college. People who continued to smoke 20 years later
were more hostile and sensation seeking. The personality
variables that predicted smoking initiation and cessation
were the same for men and women. Discussion centers on the
potential role of hostility as a predictor of smoking
cessation.},
Doi = {10.1037//0278-6133.13.2.149},
Key = {fds276143}
}
@article{fds276147,
Author = {Lane, JD and Pieper, CF and Barefoot, JC and Williams, RB and Siegler,
IC},
Title = {Caffeine and cholesterol: interactions with
hostility.},
Journal = {Psychosomatic Medicine},
Volume = {56},
Number = {3},
Pages = {260-266},
Year = {1994},
ISSN = {0033-3174},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8084973},
Abstract = {The consumption of caffeinated beverages has been linked to
elevated serum cholesterol and an increased risk of coronary
disease, although the relationships are inconsistent across
studies and remain controversial. The effect of caffeine on
cholesterol and coronary disease risk may be modulated by
other factors. Using cohort data from a subsample of the
University of North Carolina Alumni Heart Study, we
investigated whether the relationships between caffeinated
beverage consumption and serum lipid and lipoprotein levels
in middle-aged men and women were modulated by levels of
trait hostility. After adjustment for other risk factors,
higher caffeinated beverage intake was associated with
higher low-density lipoprotein cholesterol levels and a
higher ratio of total to high-density lipoprotein
cholesterol, both indicative of greater coronary disease
risk. The interactive effects of hostility and caffeine
intake were ambiguous, although there were trends for
caffeine intake to have stronger effects on low-density
lipoprotein and on total cholesterol in people with less
hostility. Additional studies of personality characteristics
and other factors that can modulate the cholesterol-raising
effects of coffee drinking may be warranted because they
might clarify the health consequences associated with coffee
drinking and lead to the identification of individuals who
would benefit most from changes in their coffee
drinking.},
Doi = {10.1097/00006842-199405000-00013},
Key = {fds276147}
}
@article{fds276244,
Author = {Lipkus, IM and Siegler, IC},
Title = {The belief in a just world and perceptions of
discrimination.},
Journal = {The Journal of Psychology},
Volume = {127},
Number = {4},
Pages = {465-474},
Year = {1993},
Month = {July},
ISSN = {0022-3980},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8254564},
Abstract = {We examined the relationship between the belief in a just
world and frequency of self-reported acts of personal
discrimination. American adults with a strong belief in a
just world reported fewer acts of personal discrimination
against themselves than those with a weak belief in a just
world. Among the various domains of discrimination, the
belief in a just world correlated most strongly with
religious discrimination. People with a strong belief in a
just world felt that they would be less likely to provide
special programs and funding based solely on a person's age;
they did not feel that age discrimination was prevalent in
American society.},
Doi = {10.1080/00223980.1993.9915583},
Key = {fds276244}
}
@article{fds276249,
Author = {Barefoot, JC and Beckham, JC and Haney, TL and Siegler, IC and Lipkus,
IM},
Title = {Age differences in hostility among middle-aged and older
adults.},
Journal = {Psychology and Aging},
Volume = {8},
Number = {1},
Pages = {3-9},
Year = {1993},
Month = {March},
ISSN = {0882-7974},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8461112},
Abstract = {Multiple measures of hostility were administered to
middle-aged and older volunteers. There was a positive
association between age and self-report measures reflecting
hostile beliefs about others, including cynicism and
suspiciousness. There was a weak inverse relationship
between age and self-report measures of the overt expression
of anger and aggression, but no association between age and
measures of covert hostility was found. There was a positive
relationship between age and an assessment of hostile
behavior that was based on the respondent's interaction
style during an interview. The magnitude of these age trends
did not differ between men (n = 50) and women (n = 75).
These findings illustrate the multidimensional nature of
hostility. They also have practical implications for older
people because hostility is associated with psychological
well-being and has been shown to have consequences for
health and longevity.},
Doi = {10.1037//0882-7974.8.1.3},
Key = {fds276249}
}
@article{fds276239,
Author = {Frazier, LD and Hooker, K and Siegler, IC},
Title = {Longitudinal studies of aging in social and psychological
gerontology},
Journal = {Reviews in Clinical Gerontology},
Volume = {3},
Number = {4},
Pages = {415-426},
Publisher = {Cambridge University Press (CUP)},
Year = {1993},
Month = {January},
url = {http://dx.doi.org/10.1017/S0959259800003658},
Doi = {10.1017/S0959259800003658},
Key = {fds276239}
}
@article{fds276093,
Author = {Zonderman, AB and Siegler, IC and Barefoot, JC and Williams, RB and Costa, PT},
Title = {Age and gender differences in the content scales of the
Minnesota Multiphasic Personality Inventory.},
Journal = {Experimental Aging Research},
Volume = {19},
Number = {3},
Pages = {241-257},
Year = {1993},
ISSN = {0361-073X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8223825},
Abstract = {We examined time of measurement, gender, and age differences
on the nine content scales of the Minnesota Multiphasic
Personality Inventory using data collected by three separate
studies during the 1950s, 1960s and 1980s. No evidence was
found for differences in the content scales due to time of
measurement that also could not have been explained by
demographic differences. Differences due to gender were
found on only one of the nine scales, Masculinity-Femininity,
and age differences were found on the Neuroticism,
Extraversion, and Agreeableness scales. Younger men and
women had significantly higher scores on the Neuroticism and
Extraversion scales, and these differences were consistent
in both magnitude and direction across sample and gender.
Our results suggest that it is likely that openness reaches
its lifetime stable level by the time typical adolescents
enter college, because we found no significant age
differences in intellectual interests. Neuroticism,
extraversion, and agreeableness on the other hand, are
likely to show instability throughout, and probably after,
adolescence and early adulthood, because we found
significant age differences in the content dimensions
associated with these factors in separate analyses of three
samples.},
Doi = {10.1080/03610739308253936},
Key = {fds276093}
}
@article{fds276238,
Author = {Hooker, K and Siegler, IC},
Title = {Life goals, satisfaction, and self-rated health: preliminary
findings.},
Journal = {Experimental Aging Research},
Volume = {19},
Number = {1},
Pages = {97-110},
Year = {1993},
ISSN = {0361-073X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8444269},
Abstract = {Several recent studies have suggested that a better
understanding of health and psychological well-being in
later life requires insights into the life goals and
motivations of research participants. However, goal
importance has not been examined separately from goal
achievement. This distinction is important for a more
fine-grained analysis of how goals may relate to adaptive
outcomes among older adults. Data from surviving respondents
of the Duke Second Longitudinal Study were analyzed in order
to replicate and extend results from previous studies.
Interestingly, a differential pattern of predictors was
found for health and satisfaction. The rated importance of
goals accounted for a significant portion of the variance in
health, but was not predictive of satisfaction, whereas
rated achievement of goals was predictive of health and
satisfaction. Results are discussed in relation to theories
of motivation in later life.},
Doi = {10.1080/03610739308253925},
Key = {fds276238}
}
@article{fds276252,
Author = {Siegler, IC and Peterson, BL and Barefoot, JC and Harvin, SH and Dahlstrom, WG and Kaplan, BH and Costa, PT and Williams,
RB},
Title = {Using college alumni populations in epidemiologic research:
the UNC Alumni Heart Study.},
Journal = {Journal of Clinical Epidemiology},
Volume = {45},
Number = {11},
Pages = {1243-1250},
Year = {1992},
Month = {November},
ISSN = {0895-4356},
url = {http://www.ncbi.nlm.nih.gov/pubmed/1432005},
Abstract = {The UNC Alumni Heart Study (UNCAHS) is a prospective study
of the role of psychosocial factors, in particular
hostility, in the development of coronary heart disease. The
target population is composed of persons who completed the
Minnesota Multiphasic Personality Inventory while attending
the University of North Carolina in the mid-1960s. Logistic
regression analyses were used to determine whether
hostility, demographic and other variables were significant
determinants of the subjects' locatability and
participation. It was found that MMPI hostility scores at
initial testing were unrelated to either potential or actual
locatability or participation. Thus there is no evidence
that hostility is the source of selection bias in the
UNCAHS. Selection into the study was predicted by age, sex,
degree status and variables concerned with the conditions
under which the MMPI was administered. It is concluded that
follow-up studies of college cohorts may have study-specific
sources of selection bias.},
Doi = {10.1016/0895-4356(92)90165-j},
Key = {fds276252}
}
@article{fds304117,
Author = {Siegler, IC and Peterson, BL and Barefoot, JC and Williams,
RB},
Title = {Hostility during late adolescence predicts coronary risk
factors at mid-life.},
Journal = {American Journal of Epidemiology},
Volume = {136},
Number = {2},
Pages = {146-154},
Year = {1992},
Month = {July},
ISSN = {0002-9262},
url = {http://www.ncbi.nlm.nih.gov/pubmed/1415138},
Abstract = {Hostility, as measured by the Cook-Medley Hostility Scale of
the Minnesota Multiphasic Personality Inventory, has been
found to predict higher rates of both coronary heart disease
and all-cause mortality. To evaluate one mechanism whereby
hostility might contribute to health problems, the authors
used regression models to determine whether hostility
measured in college (1964-1966) predicted coronary risk
factors assessed 21-23 years later (1987-1990) in 4,710 men
and women. Of this group, 828 had lipids measured
(1988-1991). Persons with higher hostility scores in college
were significantly more likely at follow-up to consume more
caffeine (r = 0.043), to have a larger body mass index (r =
0.055), to have higher lipid ratios (r = 0.092), and to be
current smokers (r = 0.069) than those with lower hostility
scores during college. Cross-sectional analyses found
significant associations of contemporaneous hostility scores
with the same four risk factors, as well as with alcohol
consumption and hypertension (rs ranging from 0.043 to
0.117). These associations are large enough to have possible
public health significance. We conclude that hostility may
contribute to health problems through its influences on
several coronary risk factors across the adult life
span.},
Doi = {10.1093/oxfordjournals.aje.a116481},
Key = {fds304117}
}
@article{fds276154,
Author = {Williams, RB and Barefoot, JC and Califf, RM and Haney, TL and Saunders,
WB and Pryor, DB and Hlatky, MA and Siegler, IC and Mark,
DB},
Title = {Prognostic importance of social and economic resources among
medically treated patients with angiographically documented
coronary artery disease.},
Journal = {Jama},
Volume = {267},
Number = {4},
Pages = {520-524},
Year = {1992},
Month = {January},
ISSN = {0098-7484},
url = {http://www.ncbi.nlm.nih.gov/pubmed/1729574},
Abstract = {OBJECTIVE: To evaluate the hypothesis that diminished social
and economic resources impact adversely on cardiovascular
mortality in patients with coronary artery disease. DESIGN:
Inception cohort study of patients undergoing cardiac
catheterization from 1974 through 1980 and followed up
through 1989. SETTING: Tertiary care university medical
center. PATIENTS: Consecutive sample of 1965 medically
treated patients with stenosis 75% or greater of at least
one major coronary artery. Five hundred patients were not
enrolled due to logistic problems; 33 refused; 64 had
missing data on key medical variables. The final study
population included 1368 patients, 82% male, with a median
age of 52 years. MAIN OUTCOME MEASURE: Survival time until
cardiovascular death. RESULTS: Independent of all known
baseline invasive and noninvasive medical prognostic
factors, patients with annual household incomes of $40,000
or more had an unadjusted 5-year survival of 0.91, compared
with 0.76 in patients with incomes of $10,000 or less (Cox
model adjusted hazard ratio, 1.9; 95% confidence interval,
1.57 to 2.32; P = .002). Similarly, unmarried patients
without a confidant had an unadjusted 5-year survival rate
of 0.50, compared with 0.82 in patients who were married,
had a confidant, or both (adjusted hazard ratio, 3.34; 95%
confidence interval, 1.84 to 6.20; P less than .0001).
CONCLUSIONS: Low levels of social and economic resources
identify an important high-risk group among medically
treated patients with coronary artery disease, independent
of important medical prognostic factors. Additional study
will be required to see if interventions to increase these
resources improve prognosis.},
Doi = {10.1001/jama.1992.03480040068032},
Key = {fds276154}
}
@article{fds276237,
Author = {Siegler, IC and Longino, CF and Johnson, C},
Title = {The Georgia Centenarian Study: comments from
friends.},
Journal = {International Journal of Aging & Human Development},
Volume = {34},
Number = {1},
Pages = {77-82},
Year = {1992},
ISSN = {0091-4150},
url = {http://www.ncbi.nlm.nih.gov/pubmed/1737662},
Doi = {10.2190/5FP0-3GL2-3RYU-Q8F9},
Key = {fds276237}
}
@article{fds276254,
Author = {Siegler, IC and Peterson, BL and Barefoot, JC and Williams,
RB},
Title = {Hostility during late adolescence predicts coronary risk
factors at midlife},
Journal = {American Journal of Epidemiology},
Volume = {138},
Number = {2},
Pages = {146-154},
Year = {1992},
ISSN = {0002-9262},
url = {http://www.ncbi.nlm.nih.gov/pubmed/1415138},
Abstract = {Hostility, as measured by the Cook-Medley Hostility Scale of
the Minnesota Multiphasic Personality Inventory, has been
found to predict higher rates of both coronary heart disease
and all-cause mortality. To evaluate one mechanism whereby
hostility might contribute to health problems, the authors
used regression models to determine whether hostility
measured in college (1964-1966) predicted coronary risk
factors assessed 21-23 years later (1987-1990) in 4,710 men
and women. Of this group, 828 had lipids measured
(1988-1991). Persons with higher hostility scores in college
were significantly more likely at follow-up to consume more
caffeine (r = 0.043), to have a larger body mass index (r =
0.055), to have higher lipid ratios (r = 0.092), and to be
current smokers (r = 0.069) than those with lower hostility
scores during college. Cross-sectional analyses found
significant associations of contemporaneous hostility scores
with the same four risk factors, as well as with alcohol
consumption and hypertension (rs ranging from 0.043 to
0.117). These associations are large enough to have possible
public health significance. We conclude that hostility may
contribute to health problems through its influences on
several coronary risk factors across the adult life
span.},
Key = {fds276254}
}
@article{fds276138,
Author = {Barefoot, JC and Peterson, BL and Dahlstrom, WG and Siegler, IC and Anderson, NB and Williams, RB},
Title = {Hostility patterns and health implications: correlates of
Cook-Medley Hostility Scale scores in a national
survey.},
Journal = {Health Psychology : Official Journal of the Division of
Health Psychology, American Psychological
Association},
Volume = {10},
Number = {1},
Pages = {18-24},
Year = {1991},
ISSN = {0278-6133},
url = {http://www.ncbi.nlm.nih.gov/pubmed/2026126},
Abstract = {Correlated Cook-Medley Hostility Scale (Ho) scores with
sociodemographic variables in a national survey of 2,536
adults. Multiple regression models revealed that Ho scores
were associated with race (p less than .0001), years of
education (p less than .001), sex (p less than .001),
occupation (p = .0002), and income (p = .0025). Higher
scores were found in non-Whites, men, and those of lower
socioeconomic status. There was a Race x Income interaction
(p less than .005), such that the greatest Ho score
differences between the races occurred among those with the
lowest incomes. Age was related to Ho scores in a
curvilinear fashion: higher scores in the youngest and
oldest age groups than in the middle-aged groups (p = .025).
Marital status was unrelated to Ho scores. These patterns of
hostility are similar to the patterns of health indicators
in the population. Because hostility has been found to be
associated with adverse health outcomes, hostility may
account for some of the demographic variations in health
status. However, it is argued that research must first
establish the generality of the hostility-health
relationship across subgroups of the population.},
Doi = {10.1037//0278-6133.10.1.18},
Key = {fds276138}
}
@article{fds276247,
Author = {Siegler, IC and Welsh, KA and Dawson, DV and Fillenbaum, GG and Earl,
NL and Kaplan, EB and Clark, CM},
Title = {Ratings of personality change in patients being evaluated
for memory disorders.},
Journal = {Alzheimer Disease and Associated Disorders},
Volume = {5},
Number = {4},
Pages = {240-250},
Year = {1991},
ISSN = {0893-0341},
url = {http://www.ncbi.nlm.nih.gov/pubmed/1781966},
Abstract = {Caregivers of 35 mildly to moderately memory-impaired
patients rated current and premorbid personalities with the
NEO Personality Inventory. We then examined changes in the
five domains of personality tapped by the NEO. There were
significant changes in four of the five domains of normal
personality functioning toward less conscientiousness, lower
extraversion, higher neuroticism, and lower openness. The
difference toward lower agreeableness was not significant
when controlling for multiple comparisons. Spearman rank
correlation coefficients indicated that changes in
conscientiousness and vulnerability were not related to
rated premorbid personality patterns and thus appear to
describe shifts for all patients evaluated for memory
disorders. These data suggest that personality inventories
may be helpful in characterizing caregivers' observations of
memory-impaired patients and thus represent a critical
source of information for the clinician in charge of
care.},
Doi = {10.1097/00002093-199100540-00003},
Key = {fds276247}
}
@article{fds276236,
Author = {Siegler, IC},
Title = {Paradigms in developmental health psychology--from theory to
application: introduction to a special issue.},
Journal = {Journal of Gerontology},
Volume = {45},
Number = {4},
Pages = {P113-P115},
Year = {1990},
Month = {July},
ISSN = {0022-1422},
url = {http://www.ncbi.nlm.nih.gov/pubmed/2365967},
Abstract = {This brief introduction sets the background for, describes,
and reviews the eight manuscripts that comprise this special
issue of the Journal of Gerontology: Psychological Sciences.
Given the topic of health, behavior, and aging it is
noteworthy that these papers speak to concerns shared by all
members of The Gerontological Society of America--from the
very definition of aging itself to how older persons live
their lives.},
Doi = {10.1093/geronj/45.4.p113},
Key = {fds276236}
}
@article{fds276246,
Author = {Koenig, HG and Siegler, IC and Meador, KG and George,
LK},
Title = {Religious coping and personality in later
life},
Journal = {International Journal of Geriatric Psychiatry},
Volume = {5},
Number = {2},
Pages = {123-131},
Publisher = {WILEY},
Year = {1990},
Month = {January},
ISSN = {0885-6230},
url = {http://dx.doi.org/10.1002/gps.930050210},
Abstract = {A stratified random subsample of 100 older adults from
long‐term participants of the Second Duke Longitudinal
Study was interviewed concerning how they coped with three
stressful event periods. Responses to open‐ended coping
questions were categorized as religious or non‐religious
in nature. Mean scores on 16 personality traits were
compared between religious copers. Few differences were
observed in personality scores between these groups.
Compared with non‐religious copers, religious copers
scored lower on factor E (less aggressive or hostile, more
humble, submissive); there was also a tendency towards being
higher on factor G (more responsible, conscientious, and
moralistic). Over a six‐year period between wave 1 and
wave 4, stability or change in personality was not related
to coping style. No evidence was found for negative
personality traits among older religious copers that have
commonly been reported in younger religious individuals.
Copyright © 1990 John Wiley & Sons, Ltd.},
Doi = {10.1002/gps.930050210},
Key = {fds276246}
}
@article{fds276253,
Author = {Siegler, IC and Zonderman, AB and Barefoot, JC and Williams, RB and Costa, PT and McCrae, RR},
Title = {Predicting personality in adulthood from college MMPI
scores: implications for follow-up studies in psychosomatic
medicine.},
Journal = {Psychosomatic Medicine},
Volume = {52},
Number = {6},
Pages = {644-652},
Year = {1990},
ISSN = {0033-3174},
url = {http://www.ncbi.nlm.nih.gov/pubmed/2287703},
Abstract = {To assess the long-term predictive utility of Minnesota
Multiphasic Personality Inventory (MMPI) content scales,
1,960 individuals who had completed the MMPI in college in
1964 or 1965 were administered two measures of adult
personality, the NEO Personality Inventory (NEO-PI) and the
Cook and Medley MMPI Hostility scale, in 1988. A comparison
group of 274 men and women in the Baltimore Longitudinal
Study of Aging were given both MMPI and NEO-PI between 1981
and 1987. Predictive correlations between MMPI scales and
NEO-PI factors were qualitatively similar to concurrent
correlations, but approximately half as large in magnitude.
Theoretically, these correlations were interpreted to mean
that about half the variance in basic dimensions of
personality is stable from college age into middle
adulthood. Practically, the relatively modest correlations
suggest that predictive studies of medical outcomes probably
require large samples, and that baseline data from adults
(e.g., over age 30) may be more useful for future studies.
The combination of stability and change suggests that the
decade of the 20s may be a particularly fruitful time to
conduct research on interventions to alter personality and
their effects on health outcomes.},
Doi = {10.1097/00006842-199011000-00006},
Key = {fds276253}
}
@article{fds276200,
Author = {Barefoot, JC and Peterson, BL and Harrell, FE and Hlatky, MA and Pryor,
DB and Haney, TL and Blumenthal, JA and Siegler, IC and Williams,
RB},
Title = {Type A behavior and survival: a follow-up study of 1,467
patients with coronary artery disease.},
Journal = {The American Journal of Cardiology},
Volume = {64},
Number = {8},
Pages = {427-432},
Year = {1989},
Month = {September},
ISSN = {0002-9149},
url = {http://www.ncbi.nlm.nih.gov/pubmed/2773785},
Abstract = {Patients with documented coronary artery disease, admitted
to Duke Medical Center between 1974 and 1980, were assessed
for type A behavior pattern and were followed until 1984.
The relation of type A behavior to survival was tested using
data from coronary angiography to control for disease
severity. Cox model regression analyses demonstrated an
interaction (p less than 0.01) between type A behavior and
an index of disease severity in the prediction of
cardiovascular death. Among those with relatively poor left
ventricular function, type A patients had better survival
than type B. This difference was not present among patients
with better prognoses. Type A behavior did not predict the
subsequent incidence of nonfatal myocardial infarctions.
Differential risk modification and differential selection
into postinfarction status are possible explanations for the
findings. These results need not conflict with the
proposition that type A behavior plays a role in the
pathogenesis of coronary artery disease.},
Doi = {10.1016/0002-9149(89)90416-5},
Key = {fds276200}
}
@article{fds276235,
Author = {McCrae, RR and Costa, PT and Dahlstrom, WG and Barefoot, JC and Siegler,
IC and Williams, RB},
Title = {A caution on the use of the MMPI K-correction in research on
psychosomatic medicine.},
Journal = {Psychosomatic Medicine},
Volume = {51},
Number = {1},
Pages = {58-65},
Year = {1989},
ISSN = {0033-3174},
url = {http://www.ncbi.nlm.nih.gov/pubmed/2928461},
Abstract = {The MMPI K scale is widely used to screen for invalid
responses and to adjust substantive scale scores for
defensiveness. In a normal volunteer sample, correlations of
MMPI clinical scales and the Cook-Medley Hostility (HO)
scale with self-reports and peer ratings on the NEO
Personality Inventory (NEO-PI) were decreased rather than
increased by K-correction. Similarly, in a medical sample,
structured interview-based ratings of Potential for
Hostility were better predicted by uncorrected HO scores
than by K-corrected HO scores. Finally, in a prospective
study of mortality among lawyers, uncorrected HO scores were
a significant predictor of all-cause mortality; K-corrected
scores were not. The data suggest that, under some
circumstances, the K scale may measure substantive traits
rather than defensiveness, and should be used and
interpreted with caution. Its use is probably
contraindicated for most research on psychiatrically normal
subjects.},
Doi = {10.1097/00006842-198901000-00006},
Key = {fds276235}
}
@article{fds315579,
Author = {Koenig, HG and Siegler, IC and George, LK},
Title = {Religious and Non-Religious Coping: Impact on Adaptation in
Later Life},
Journal = {Journal of Religion and Aging},
Volume = {5},
Number = {4},
Pages = {73-94},
Publisher = {The Haworth Press},
Year = {1989},
ISSN = {0738-6184},
url = {http://dx.doi.org/10.1300/J491v05n04_07},
Abstract = {Religious behaviors are commonly used by older persons to
cope with stressful life-events and situations. In the
present study, adaptation and coping were examined in a
stratified random sample of 100 persons age 55 to 80
participating in the Second Duke Longitudinal Study of
Aging. Twelve established social psychological measures of
adaptation and coping were utilized for this purpose. Mean
scores were compared between persons using religious
behaviors and those using other coping behaviors. Social
class, amount of life-stress experienced, and type of
stressors were also compared between religious and
non-religious copers. No significant difference was observed
between religious and non-religious copers on any of the 12
measures of coping and adaptation. Stratifying the sample by
sex did not alter these results. A small proportion of the
sample (7%) were distinguished by the degree to which
religion had permeated their coping behaviors and outlook on
life. Despite being. © Taylor © Francis Group,
LLC.},
Doi = {10.1300/J491v05n04_07},
Key = {fds315579}
}
@article{fds276245,
Author = {Koenig, HG and George, LK and Siegler, IC},
Title = {The use of religion and other emotion-regulating coping
strategies among older adults.},
Journal = {Gerontologist},
Volume = {28},
Number = {3},
Pages = {303-310},
Year = {1988},
Month = {June},
ISSN = {0016-9013},
url = {http://www.ncbi.nlm.nih.gov/pubmed/3396911},
Doi = {10.1093/geront/28.3.303},
Key = {fds276245}
}
@article{fds276137,
Author = {Barefoot, JC and Siegler, IC and Nowlin, JB and Peterson, BL and Haney,
TL and Williams, RB},
Title = {Suspiciousness, health, and mortality: a follow-up study of
500 older adults.},
Journal = {Psychosomatic Medicine},
Volume = {49},
Number = {5},
Pages = {450-457},
Year = {1987},
ISSN = {0033-3174},
url = {http://www.ncbi.nlm.nih.gov/pubmed/3671634},
Abstract = {Scores on Factor L of the 16 PF, a measure of suspiciousness
that is closely related to the Cook and Medley hostility
scale, predicted survival in a sample of 500 older men and
women during a follow-up of approximately 15 years. Those
individuals with scores indicating higher levels of
suspiciousness had greater mortality risk. This association
remained significant after controlling for age, sex,
physician's ratings of functional health, smoking,
cholesterol, and alcohol intake. In addition, Factor L was
associated with physician's ratings of health at the
initiation of follow-up. These findings add to the weight of
evidence that implicates a set of negative interpersonal
attitudes in the domain of hostility, anger, cynicism, and
mistrust as a prospective marker of individuals at risk for
adverse health outcomes.},
Doi = {10.1097/00006842-198709000-00002},
Key = {fds276137}
}
@article{fds276199,
Author = {Hooker, K and Blumenthal, JA and Siegler, I},
Title = {Relationships between motivation and hostility among type A
and type B middle-aged men},
Journal = {Journal of Research in Personality},
Volume = {21},
Number = {2},
Pages = {103-113},
Year = {1987},
ISSN = {0092-6566},
url = {http://dx.doi.org/10.1016/0092-6566(87)90001-8},
Abstract = {Relationships between aspects of personality and the Type A
behavior pattern (TABP) were examined in a sample of 60
middle-aged men. TABP classification was determined by the
Structured Interview (SI) and the Jenkins Activity Survey
(JAS), while aspects of personality functioning were
measured by the Thematic Apperception Test (TAT) and the
Jackson Personality Research Form (PRF). It was hypothesized
that Type A men would score higher than Type B men on the
motivational drives of need for achievement and need for
power, and that there would be proportionately more Type As
than Bs displaying the Inhibited Power Motive Syndrome
(IPMS). The Aggression and Defendence scales of the PRF were
combined to form a measure of hostility (PRF-hostility) and
relationships between need for power, hostility, and TABP
were examined. Results showed that these motivational
variables were not directly related to TABP. However, there
was a strong interaction such that Type As high in need for
power tended to score highly on PRF-hostility and Type Bs
high in need for power tended to rate themselves as low on
PRF-hostility. This suggests that need for power may play a
role in the expression of hostility, and that this differs
for Type A and Type B middle-aged men. ©
1987.},
Doi = {10.1016/0092-6566(87)90001-8},
Key = {fds276199}
}
@article{fds276091,
Author = {Manton, KG and Siegler, IC and Woodbury, MA},
Title = {Patterns of intellectual development in later
life.},
Journal = {Journal of Gerontology},
Volume = {41},
Number = {4},
Pages = {486-499},
Year = {1986},
Month = {July},
ISSN = {0022-1422},
url = {http://www.ncbi.nlm.nih.gov/pubmed/3722733},
Abstract = {Temporal changes in 16 measures of cognitive and
intellectual functioning (11 Wechsler Adult Intelligence
Scale subtests, 3 Wechsler Memory Test subscales, 2 measures
of reaction time) were studied in the full data set from the
First Duke Longitudinal Study of Aging. Patterns of change
in these 16 measures were identified through a
'grade-of-membership' analysis -- a general model for
identifying patterns in temporal variation that does not
require parametric assumptions about the trajectory of
change or assumptions about the homogeneity of the sampled
population. The analyses showed that the temporal variation
of the 16 measures could be described by five latent
patterns that reflected the complex patterning of
intellectual functioning in extreme late life. The relation
of these five patterns of intellectual ability to age was
examined, as were the relationships to measures of mental
and physical health. These results underline the needs for
comprehensive models of health and functioning in later life
that describe changes in a multidimensional
form.},
Doi = {10.1093/geronj/41.4.486},
Key = {fds276091}
}
@article{fds276088,
Author = {Clive, J and Woodbury, MA and Siegler, IC},
Title = {FUZZY AND CRISP SET-THEORETIC BASED CLASSIFICATION OF HEALTH
AND DISEASE: A QUALITATIVE AND QUANTITATIVE
COMPARISON.},
Journal = {Proceedings of the Hawaii International Conference on System
Science},
Pages = {450-462},
Year = {1983},
Month = {December},
Abstract = {Conventional cluster analyses of patient populations are
intended to assist in the identification and
characterization of groups which may represent etiological
or pathological subtypes within a particular disease class.
These methods have been criticized as being insensitive to
subtle patient differences, which may be masked as a result
of the all or nothing concept of cluster membership
intrinsic to crisp set-theoretic based grouping algorithms.
This paper compares and contrasts the applications of crisp
and fuzzy set-theoretic based clustering procedures to a set
of data describing the cognitive and intellectual
functioning of a group of subjects participating in a
longitudinal study of aging. Emphasis is placed on
qualitative and quantitative aspects, corresponding,
respectively, to the clinical interpretation of cluster
definitions, and the robustness or sensitivity of the
classification procedures to changes in patient profiles
over time.},
Key = {fds276088}
}
@article{fds276089,
Author = {Siegler, IC and George, LK},
Title = {The normal psychology of the aging male: Sex differences in
coping and perceptions of life events},
Journal = {Journal of Geriatric Psychiatry},
Volume = {16},
Number = {2},
Pages = {197-209},
Year = {1983},
Month = {December},
Abstract = {The data illustrate some important methodological
considerations about the study of life events and the study
of developmental data. As the data on the distribution of
life events indicate, when individuals retell their life
stories, events are rarely discrete. Psychologically, an
event expands to include those predictors that later became
apparent and the time taken to put the event into
perspective. This calls into question the interpretation
given to many life event questionnaires that seek to
consider an event within narrow time framework. Positive and
negative events appear to have differential
consequences.},
Key = {fds276089}
}
@article{fds276092,
Author = {Clive, J and Woodbury, MA and Siegler, IC},
Title = {Fuzzy and crisp set-theoretic-based classification of health
and disease. A qualitative and quantitative
comparison.},
Journal = {Journal of Medical Systems},
Volume = {7},
Number = {4},
Pages = {317-332},
Year = {1983},
Month = {August},
ISSN = {0148-5598},
url = {http://www.ncbi.nlm.nih.gov/pubmed/6644199},
Abstract = {Conventional cluster analyses of patient populations are
intended to assist in the identification and
characterization of groups that may represent etiological or
pathological subtypes within a particular disease class.
These methods have been criticized as being insensitive to
subtle patient differences, which may be masked as a result
of the all-or-nothing concept of cluster membership
intrinsic to crisp set-theoretic-based grouping algorithms.
As an alternative to conventional clustering procedures,
several investigators have studied the use of fuzzy
classification methods. In general, these measure a
patient's clinical status in terms of a real number defined
on the closed unit interval, reflecting the extent or degree
to which a particular grouping entity characterizes the
patient. This paper compares and contrasts the applications
of crisp and fuzzy set-theoretic-based clustering procedures
to a set of data describing the cognitive and intellectual
functioning of a group of subjects participating in a
longitudinal study of aging. Emphasis is placed on both
qualitative and quantitative aspects corresponding,
respectively, to the clinical interpretation of cluster
definitions, and the robustness or sensitivity of the
classification procedures to changes in patient profiles
over time. The fuzzy set-theoretic-based model was found to
be more sensitive to changes in subject level of functioning
over time, to provide superior quantitative protrayals of
patterns of aging, and to reflect properties of the aging
process derived from other research.},
Doi = {10.1007/BF01080688},
Key = {fds276092}
}
@article{fds276090,
Author = {Siegler, IC and George, LK},
Title = {Sex differences in coping and perceptions of life
events.},
Journal = {Journal of Geriatric Psychiatry},
Volume = {16},
Number = {2},
Pages = {197-122},
Year = {1983},
ISSN = {0022-1414},
url = {http://www.ncbi.nlm.nih.gov/pubmed/6677679},
Abstract = {These data illustrate some important methodological
considerations about the study of life events and the study
of developmental data. As the data on the distribution of
life events indicate, when individuals retell their life
stories, events are rarely discrete. Psychologically, an
event expands to include those predictors that later became
apparent and the time taken to put the event into
perspective. This calls into question the interpretation
given to many life event questionnaires that seek to
consider an event within a narrow time framework. Positive
and negative events appear to have differential
consequences. Our exploration of coping with positive events
was an interesting one. Most of our respondents did not
perceive that they had a coping task to accomplish when the
event was perceived as a positive one. Many of the events
reported by our respondents were events in the lives of
others. Although this was more often the case for women than
for men, interpersonal events and events in which the major
impact fell on a family member were quite common in later
life. In attempting to understand the impact of
sociohistorical events as a context for development, it has
often been assumed that overall negative events such as wars
and economic depressions will have predominantly negative
impacts. Our data suggest that sociohistorical events form
the context for events in the family life cycle that happen
independently of what is happening in the larger society.
Events related to family formation happened against
different backgrounds of sociohistorical events. These data
also suggest that we look for cohort effects in nonlinear
ways that would reflect generational communality of an
event. This study also has limits. Our sample was small, and
as the respondents had maximum freedom to pick the events to
be discussed, we only know that we had a sample of three
positive and three negative event contexts. We did not ask
individuals 500 many positive and negative events they had
during their lives and how the events mentioned fit into
that ranking. The interviews were rich in the individuals'
perceptions of the important aspects of their lives and
indicated a realistic group of persons who had managed to
cope reasonably well with the events in their lives. The
cohorts in the study are of the age that traditional gender
differences are founded on. Looking at the content of the
issues to be coped with and the requirements of the
situation suggest that life experience is what is predictive
of coping skills.(ABSTRACT TRUNCATED AT 400
WORDS)},
Key = {fds276090}
}
@article{fds276086,
Author = {Siegler, IC and McCarty, SM and Logue, PE},
Title = {Wechsler Memory Scale Scores, selective attrition, and
distance from death.},
Journal = {Journal of Gerontology},
Volume = {37},
Number = {2},
Pages = {176-181},
Year = {1982},
Month = {March},
ISSN = {0022-1422},
url = {http://www.ncbi.nlm.nih.gov/pubmed/7057002},
Doi = {10.1093/geronj/37.2.176},
Key = {fds276086}
}
@article{fds276087,
Author = {McCarty, SM and Siegler, IC and Logue, PE},
Title = {Cross-sectional and longitudinal patterns of three Wechsler
Memory Scale Subtests.},
Journal = {Journal of Gerontology},
Volume = {37},
Number = {2},
Pages = {169-175},
Year = {1982},
Month = {March},
ISSN = {0022-1422},
url = {http://www.ncbi.nlm.nih.gov/pubmed/6976984},
Abstract = {This study evaluated cross-sectional and longitudinal age
relationships, after age 60, for three subtests of the
Wechsler Memory Scale: logical memory, associate learning,
and visual reproduction. Cross-sectional regression analyses
indicated that age, sex, race, and education accounted for
approximately 20 to 35% of the variance in test scores, with
education the strongest predictor. Longitudinally,
consistent linear declines were found only for hard
associates and visual reproduction. Visual reproduction was
related more consistently and strongly to age than the two
verbal subtests. The effects of selective attrition from the
study were discussed.},
Doi = {10.1093/geronj/37.2.169},
Key = {fds276087}
}
@article{fds276085,
Author = {Siegler, IC and Cunningham, WR},
Title = {Methodological comments: From a symposium methodological
considerations for aging research: Introduction to a
symposium and methodological commentary},
Journal = {Experimental Aging Research},
Volume = {8},
Number = {1},
Pages = {59-60},
Publisher = {Informa UK Limited},
Year = {1982},
Month = {January},
url = {http://dx.doi.org/10.1080/03610738208258396},
Abstract = {This article introduces a set of papers which illustrate the
application of multivariate techniques to problems in aging
research. Multivariate research strategies raise new issues
in the choice of sample size that are discussed. The papers
reviewed in this introduction are concerned with factorial
invariance, the measurement of change, and various
regression techniques useful in modeling developmental data.
© 1982 Taylor & Francis Group, LLC.},
Doi = {10.1080/03610738208258396},
Key = {fds276085}
}
@article{fds315577,
Author = {Hyer, L and Matteson, MA and Siegler, IC},
Title = {Locus of Control and Long-term Care},
Journal = {Journal of Applied Gerontology},
Volume = {1},
Number = {1},
Pages = {147-160},
Publisher = {SAGE Publications},
Year = {1982},
Month = {January},
ISSN = {0733-4648},
url = {http://dx.doi.org/10.1177/073346488200100118},
Abstract = {Locus of control is a variable of high interest in the
assessment and behavior of the elderly in long-term care
(LTC) facilities. This study uses a situation-specific locus
of control (LOC) index and controls for the influential
variables in an LTC setting: age, education, sex,
depression, and cognitive decline. Having an in ternal LOC
proved to influence various adjustment measures, including
behavior rating, perception of environment, and psychiatric
factors. The value and use of such a specialized LOC measure
in LTC settings are stressed and discussed. © 1982, Sage
Publications. All rights reserved.},
Doi = {10.1177/073346488200100118},
Key = {fds315577}
}
@article{fds304116,
Author = {Woodbury, MA and Manton, KG and Siegler, IC},
Title = {Markov Network Analysis: suggestions for innovations in
covariance structure analysis.},
Journal = {Experimental Aging Research},
Volume = {8},
Number = {3-4},
Pages = {135-140},
Year = {1982},
ISSN = {0361-073X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/6984834},
Abstract = {Studies of aging offer special methodological challenges to
the researcher in that he must often examine the change of
multiple correlated variables over time. We present a set of
procedures that are specifically designed to model change in
such multivariate situations. These procedures, which we
will call Markov Network Analysis, are directly applicable
to modeling change from longitudinal or serial data. In such
cases, the parameters of the model have dynamic
interpretations, e.g., as coefficients in positive or
negative feedback loops. In cross-sectional data, one cannot
directly estimate the dynamic coefficients but the model
does show how certain dynamic interpretations can be made.
Statistically, maximum likelihood estimation procedures are
developed and presented. In the development of the
statistical model, it is shown how the bias of sequential
hypothesis testing, a frequent occurrence in the estimation
of complex covariance structure models, may be
reduced.},
Doi = {10.1080/03610738208260270},
Key = {fds304116}
}
@article{fds276084,
Author = {George, LK and Siegler, IC and Okun, MA},
Title = {Separating age, cohort, and time of measurement: analysis of
variance or multiple regression.},
Journal = {Experimental Aging Research},
Volume = {7},
Number = {3},
Pages = {297-314},
Year = {1981},
ISSN = {0361-073X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/7318857},
Abstract = {This paper empirically compares the relative advantages of
analysis of variance (ANOVA) and multiple regression (MR)
approaches to the separation of age, cohort, and time of
measurement effects in sequential research designs. The
comparison utilizes four synthetic data sets, designed to
have specific characteristics. The results support Adam's
recent claim that standard ANOVA procedures, as described by
Schaie, do not permit the development of accurate decision
rules for age-period-cohort analysis. A modified dummy
variable regression procedure developed by Mason, et al. is
demonstrated to permit accurate attribution of variance
among age, cohort, and time of measurement effects in the
developmental model.},
Doi = {10.1080/03610738108259812},
Key = {fds276084}
}
@article{fds276083,
Author = {Botwinick, J and Siegler, IC},
Title = {Intellectual ability among the elderly: Simultaneous
cross-sectional and longitudinal comparisons},
Journal = {Developmental Psychology},
Volume = {16},
Number = {1},
Pages = {49-53},
Publisher = {American Psychological Association (APA)},
Year = {1980},
Month = {January},
ISSN = {0012-1649},
url = {http://dx.doi.org/10.1037/0012-1649.16.1.49},
Abstract = {Made simultaneous cross-sectional and longitudinal
comparisons of WAIS performances of 70 Ss. The comparisons
were such that approximately 4 yrs separated the age groups
both cross-sectionally and longitudinally. The groups were
aged 60-63, 64-67, 68-71, and 72-75 yrs. The results
indicate no significant age differences with the
cross-sectional comparison but significant age differnces
with the longitudinal comparisons. The latter differences,
however, were small. It is concluded that when the age spans
of cross-sectional and longitudinal comparisons are
equivalent and when equivalent S selection factors are
applied to these 2 designs, the results are similar. (12
ref) (PsycINFO Database Record (c) 2006 APA, all rights
reserved). © 1980 American Psychological
Association.},
Doi = {10.1037/0012-1649.16.1.49},
Key = {fds276083}
}
@article{fds276072,
Author = {Palmore, E and Cleveland, WP and Nowlin, NB and Ramm, D and Siegler,
IC},
Title = {Stress and adaptation in later life.},
Journal = {Journal of Gerontology},
Volume = {34},
Number = {6},
Pages = {841-851},
Year = {1979},
Month = {November},
ISSN = {0022-1422},
url = {http://www.ncbi.nlm.nih.gov/pubmed/512304},
Abstract = {The effects of five major life events, and of three types of
resources, on the physical and social-psychological
adaptation of 375 participants in a longitudinal study were
examined. As expected, medical events had the most impact on
physical adaptation, but they had surprisingly little impact
on social-psychological adaptation. Retirement had the most
negative social-psychological effects, but had little effect
on physical adaptation. The other three events had even less
effects, although multiple events tended to cumulate in
impact. Better physical resources helped only physical
adaptation, and better psychological and social resources
mainly helped satisfaction. It appears that most of these
potential stressors have less serious long-term outcomes
than the crisis orientation would suggest.},
Doi = {10.1093/geronj/34.6.841},
Key = {fds276072}
}
@article{fds276081,
Author = {Siegler, IC and Botwinick, J},
Title = {A long-term longitudinal study of intellectual ability of
older adults: the matter of selective subject
attrition.},
Journal = {Journal of Gerontology},
Volume = {34},
Number = {2},
Pages = {242-245},
Year = {1979},
Month = {March},
ISSN = {0022-1422},
url = {http://www.ncbi.nlm.nih.gov/pubmed/438478},
Abstract = {Two hundred and forty-six subjects aged 60 to 94 were tested
with the WAIS at test session 1, the start of a longitudinal
study which lasted approximately 20 years. The subject
attrition from the first session to the last (session No.
11) was progressive and selective, leaving mainly the
intellectually superior ones in the study. Two facts
appeared particularly important: One, little intellectual
decline was seen in these superior subjects until very late
in life. Two, analyses based on such superior subjects
without reference to the larger body of subject populations
can lead to spurious generalizations about aging in general.
Age decline in intellectual ability seen in more
representative populations may not be apparent when
analyzing data of select samples.},
Doi = {10.1093/geronj/34.2.242},
Key = {fds276081}
}
@article{fds276082,
Author = {Gatz, M and Siegler, IC and Dibner, SS},
Title = {Individual and community: normative conflicts in the
development of a new therapeutic community for older
persons.},
Journal = {International Journal of Aging & Human Development},
Volume = {10},
Number = {3},
Pages = {249-263},
Year = {1979},
ISSN = {0091-4150},
url = {http://www.ncbi.nlm.nih.gov/pubmed/521183},
Abstract = {This paper examines the role of ideology in the
establishment of a new therapeutic community for geriatric
patients in a state mental hospital. Contradictory role
expectations, reflected both in staff-staff and in
staff-patient relationship, interfered with the program's
achieving its stated goals. In order to apply a humanistic
approach to programs for elderly patients, realistic
goals-encompassing the range of patient competence-must be
set within a reasonable time framework, and the program must
provide for an appropriate range of structure.},
Doi = {10.2190/j1yf-ryxv-bcd8-p9pr},
Key = {fds276082}
}
@article{fds276080,
Author = {Okun, MA and Siegler, IC and George, LK},
Title = {Cautiousness and verbal learning in adulthood.},
Journal = {Journal of Gerontology},
Volume = {33},
Number = {1},
Pages = {94-97},
Year = {1978},
Month = {January},
ISSN = {0022-1422},
url = {http://www.ncbi.nlm.nih.gov/pubmed/618972},
Abstract = {Twenty-two young (age 17-21)and 22 old (age 60-74) men and
women participated in an investigation designed to determine
the extent to which age differences in omission errors and
performance in a serial learning task are accounted for by
cautiousness. Age differences were found on the measures of
cautiousness, and verbal learning, with young adults making
more correct responses and proportionately fewer omission
errors on the learning task and taking greater risks on the
risk-taking tasks. The results indicated that cautiousness
measures accounted for age differences in omission errors
but not in performance.},
Doi = {10.1093/geronj/33.1.94},
Key = {fds276080}
}
@article{fds276078,
Author = {Okun, MA},
Title = {Sex differences in serial learning for aged persons with
high verbal ability.},
Journal = {Experimental Aging Research},
Volume = {3},
Number = {2},
Pages = {165-169},
Year = {1977},
Month = {March},
url = {http://dx.doi.org/10.1080/03610737708257096},
Abstract = {Serial rote learning was examined in men and women with high
verbal ability aged 60-74 years. No sex differences were
found in total errors, commission errors, or omissions
errors. The results are in accord with the findings reported
in a study by Wilkie and Eisdorfer (1977) and suggest that
high verval ability may, in part, mediate sex differences in
serial learning.},
Doi = {10.1080/03610737708257096},
Key = {fds276078}
}
@article{fds276079,
Author = {Okun, MA and Siegler, IC},
Title = {The perception of outcome-effort covariation in younger and
older men},
Journal = {Educational Gerontology},
Volume = {2},
Number = {1},
Pages = {27-32},
Publisher = {Informa UK Limited},
Year = {1977},
Month = {January},
url = {http://dx.doi.org/10.1080/0360127770020104},
Abstract = {The subjects, 21 younger (average CA = 18.95, SD = 1.13) and
21 older (average CA = 68.62, SD = 4.75) men, participated
in a bogus convergent-thinking task in which they rated
their effort expenditure after experiencing varying degrees
of success. It was proposed that younger, but not older men
would exhibit outcome-effort covariation. As predicted,
results indicated that younger, but not older men perceived
that they tried harder when they succeeded relative to when
they failed. The findings imply that the older men’s lack
of outcome-effort covariation has inimical consequences for
their learning in contexts where initial failure experiences
are likely. “Attribution retraining” was suggested as a
potential intervention strategy. Research with older adults
is advocated to examine whether causal ascription of failure
to lack of effort is related to persistence at the task. ©
1977 Taylor & Francis Group, LLC.},
Doi = {10.1080/0360127770020104},
Key = {fds276079}
}
@article{fds276077,
Author = {Okun, MA and Siegler, IC},
Title = {Relation between preference for intermediate risk and adult
age in men: A cross-cultural validation},
Journal = {Developmental Psychology},
Volume = {12},
Number = {6},
Pages = {565-566},
Publisher = {American Psychological Association (APA)},
Year = {1976},
Month = {November},
ISSN = {0012-1649},
url = {http://dx.doi.org/10.1037/0012-1649.12.6.565},
Abstract = {Investigated the generalizability of the N. P. Chaubey (see
record 1974-27278-001) finding of an inverse relation
between adult age and magnitude of preference for
intermediate risk in Asian Indian males. 11 17-21 yr old
undergraduates and 11 60-74 yr old volunteers from the
community individually completed a task which was oriented
about the Verbal Ability Test. Ss chose their preferred
difficulty level and were afforded points based on their
performance. An index of the preference for intermediate
risk was derived by obtaining the absolute value of the
difference between the probability of success at which the S
chose to work and .50. Analysis of variance applied to data
based on the risk index revealed that older Ss exhibited
significantly less preference for intermediate risk than did
younger Ss. Results of this study considered in conjunction
with those of the Chaubey study indicate that the preference
for intermediate risk in males has a strong, reliable,
replicable relation to adult age. It is suggested that
future research study intermediate risk in females.
(PsycINFO Database Record (c) 2006 APA, all rights
reserved). © 1976 American Psychological
Association.},
Doi = {10.1037/0012-1649.12.6.565},
Key = {fds276077}
}
@article{fds276076,
Author = {Smyer, MA and Siegler, IC},
Title = {Learning to live in a therapeutic community: a study of
elderly inpatients.},
Journal = {International Journal of Aging & Human Development},
Volume = {7},
Number = {3},
Pages = {231-235},
Year = {1976},
ISSN = {0091-4150},
url = {http://www.ncbi.nlm.nih.gov/pubmed/1002328},
Abstract = {Fifty-two elderly mental patients in a state hospital were
transferred to a new milieu ward. In order to evaluate
patient success in the unit, three outcome categories were
defined nine months after the unit opened: discharge to the
community, adjustment to the setting, and return to the
previous ward. Despite the unit's emphasis on performance
criteria for success, staff evaluations of the patients'
personality rather than the patients' achievement of the
behavioural criteria, accounted for success in the
setting.},
Doi = {10.2190/HFYD-YE6P-YBLM-UH4H},
Key = {fds276076}
}
@article{fds276074,
Author = {Siegler, IC},
Title = {The terminal drop hypothesis: fact or artifact?},
Journal = {Experimental Aging Research},
Volume = {1},
Number = {1},
Pages = {169-185},
Year = {1975},
Month = {September},
ISSN = {0361-073X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/802856},
Abstract = {Findings from eight longitudinal investigations were
reviewed in order to evaluate the terminal drop hypothesis.
The concept of terminal drop was seen to be more useful when
partitioned into its component parts: the relationship
between the level of cognitive performance with survival and
with distance from death, and the relationship between
changes in cognitive performance and death. Health status
and age at death emerged as important intervening variables
in understanding the terminal drop concept.},
Doi = {10.1080/03610737508257957},
Key = {fds276074}
}
@article{fds276075,
Author = {Eisner, HC and Siegler, IC and Eisele, FR},
Title = {Contemporary views on behavioral development: A review of
the 1973 meetings of the international society for the study
of behavioral development},
Journal = {Human Development},
Volume = {17},
Number = {3},
Pages = {231-234},
Publisher = {S. Karger AG},
Year = {1974},
Month = {January},
ISSN = {0018-716X},
url = {http://dx.doi.org/10.1159/000271346},
Doi = {10.1159/000271346},
Key = {fds276075}
}
%% Papers Published
@article{fds138405,
Title = {Ilene C. Siegler, Ph.D., MPH},
Year = {2001},
Key = {fds138405}
}
@article{fds138406,
Title = {Dawson, D.V., Welsh-Bohmer, K., & Siegler, I.C. (2001).
Informant rated personality change in Alzheimer disease
patients: Replication, influence of premorbid profile, and
covariate relationships. Research and Practice in
Alzheimer's Disease, 5, 27-32},
Year = {2001},
Key = {fds138406}
}
@article{fds138407,
Title = {Siegler, I.C., Bastian, L.A., & Bosworth, H.B. (2001).
Health, behavior, and aging. In A. Baum, T.R. Revenson, &
J.E. Singer (Eds.), Handbook of health psychology. (pp.
469-476). Mahwah, NJ: Erlbaum.},
Year = {2001},
Key = {fds138407}
}
@article{fds138408,
Title = {In Press: Siegler, I.C., Bastian, L.A., Steffens, D.C.,
Bosworth, H.B., & Costa, P.T. (in press). Behavioral
medicine and aging: Middle age, aging and the oldest-old.
Journal of Consulting and Clinical Psychology.},
Year = {2001},
Key = {fds138408}
}
@article{fds138409,
Title = {Vitaliano, P.O., Scanlan, J.M., Zhang, J., Savage, M.V.,
Hirsch, I.B., & Siegler, I.C. (in press). A path model of
chronic stress, the Metabolic Syndrome, and coronary heart
disease. Psychosomatic Medicine.},
Year = {2001},
Key = {fds138409}
}
@article{fds138410,
Title = {Bosworth, H.B., & Siegler, I.C. (in press). Terminal change
in cognitive function: An updated review of longitudinal
studies. Experimental Aging Research.},
Year = {2001},
Key = {fds138410}
}
@article{fds138455,
Title = {Bosworth, H.B., Feaganes, J.R., Vitaliano, P.P., Mark, D.B.,
& Siegler, I.C. (2001). Personality and coping with a common
stressor: Cardiac catheterization. Journal of Behavioral
Medicine 24, 17-31.},
Year = {2001},
Key = {fds138455}
}
@article{fds138456,
Title = {Williams, R.B., Marchuk, D.A., Gadde, K.M., Barefoot, J.C.,
Grichnik, K., Helms, M.J., Kuhn, C.M., Lewis, J.G.,
Schanberg, S.M., Stafford-Smith, M., Suarez, E.C., Clary,
G.L., Svenson, I.K., & Siegler, I.C. (2001). Central nervous
system serotonin function and cardiovascular responses to
stress. Psychosomatic Medicine, 63, 300-305.},
Year = {2001},
Key = {fds138456}
}
@article{fds138457,
Title = {Brummett, B.H., Barefoot, J.C., Siegler, I.C.,
Clapp-Channing, N.E., Lytle, B., Bosworth, H.B., Williams,
R.B., & Mark, D.B. (2001). Characteristics of socially
isolated cardiac patients at elevated risk for mortality.
Psychosomatic Medicine, 63, 267-272.},
Year = {2001},
Key = {fds138457}
}
@article{fds138458,
Title = {Vitaliano, P.P., Scanlan, J.M., Zhang, J., Savage, M.V.,
Brummett, B., Barefoot, J., & Siegler I.C. (2001). Are the
salutogenic effects of social support modified by income? A
test of an "added value hypothesis". Health Psychology,
20(3), 155-165.},
Year = {2001},
Key = {fds138458}
}
@article{fds138459,
Title = {Bosworth, H.B., Bastian, L.A., Kuchitbhatta, M., Steffens,
D.C., McBride, C.M., Skinner, C.S., Rimer, B.K., & Siegler,
I.C. (2001). Depressive symptoms, menopausal status, and
climacteric symptoms in women at mid-life. Psychosomatic
Medicine, 63, 603-608.},
Year = {2001},
Key = {fds138459}
}
@article{fds138460,
Title = {Siegler, I.C., Bosworth, H.B., & Poon, L.W. (in press).
Disease, health and aging. In R.M. Lerner, MA Easterbrooks,
& J Mistri (Eds.), Comprehensive handbook of psychology,
vol. 6. Developmental Psychology. New York: Wiley and
Son.},
Year = {2001},
Key = {fds138460}
}
@article{fds138461,
Title = {Siegler IC, Bosworth, H. B., & Elias, M. F. (in press).
Adult development and aging in health psychology. In A.M.
Nezu, C.M. Nezu, & P.A. Geller (Eds.) Comprehensive handbook
of psychology, v. 9 Health psychology. New York: Wiley and
Son.},
Year = {2001},
Key = {fds138461}
}
@article{fds138462,
Title = {Yen, S., & Siegler, I.C. (in press). Relationship between
self-blame, social introversion and suicide: Prospective
data from a longitudinal study. Archives of Suicide
Research.},
Year = {2001},
Key = {fds138462}
}
@article{fds138463,
Title = {Bastian, L.A., Owens, S.S., Kim, H., Barnett, L.R., &
Siegler, I.C. (in press). Cigarette smoking in veteran
women: The impact of multiple role strain. Women's Health
Issues.},
Year = {2001},
Key = {fds138463}
}
@article{fds138464,
Title = {Steffens, D.C., Svenson, I., Marchuk, D.A., Levy, R.M.,
Hays, J.C., Flint, E.P., Krishnan, K.R.R., & Siegler, I.C.
(in press). Allelic differences in the serotonin
transporter-linked polymorphic region in geriatric
depression. American Journal of Geriatric
Psychiatry.},
Year = {2001},
Key = {fds138464}
}
@article{fds138465,
Title = {Calhoun, P., Bosworth, H.B., Siegler, I.C., & Bastian, L.A.
(in press). The relationship between hostility and
behavioral risk factors for poor health in women veterans.
Preventive Medicine.},
Year = {2001},
Key = {fds138465}
}
@article{fds138466,
Title = {Weng, H.H., McBride, C.M., Bosworth, H.B., Grambow, S.C.,
Siegler, I.C., & Bastian, L.A. (in press). Racial
differences in physician recommendation of hormone
replacement therapy. Preventive Medicine.},
Year = {2001},
Key = {fds138466}
}
@article{fds138467,
Title = {McBride, C.M., Bastian, L.A., Halabi, S., Fish, L., Lipkus,
I.M., Bosworth, H.B., Rimer, B.K., & Siegler, I.C. (in
press). Efficacy of a tailored intervention to aid
decision-making about hormone replacement therapy. American
Journal of Public Health.},
Year = {2001},
Key = {fds138467}
}
@article{fds138468,
Title = {Barefoot, J.C., Gronbaek, M., Feaganes, J.R., McPherson,
R.S., Williams, R.B., & Siegler, I.C. (in press). Alcoholic
beverage preference, diet, and health habits in the UNC
Alumni Heart Study. American Journal of Clinical
Nutrition.},
Year = {2001},
Key = {fds138468}
}
@article{fds138397,
Title = {2. Barefoot, J,C., Heitmann, B.L., Helms, M.J., Williams,
R.B., Surwit, R.S., & Siegler, I.C. (1998). Symptoms of
depression and changes in body weight from adolescence to
mid-life. International Journal of Obesity, 22,
688-694.},
Year = {1998},
Key = {fds138397}
}
@article{fds138398,
Title = {4. Bastian, L.A., Couchman, G.M., Nanda, K., & Siegler, I.C.
(1998). Hormone replacement therapy: Benefits, risks and
management.. Clinic Atlas on Office Gynecology, 1,
79-87.},
Year = {1998},
Key = {fds138398}
}
@article{fds138399,
Title = {6. Vitaliano, P.P., Scanlan, J.M., Siegler, I.C., McCormick,
W.C., & Knopp, R.H. (1998). Coronary heart disease moderates
the relationship of chronic stress with the metabolic
syndrome. Health Psychology, 17, 520-529.},
Year = {1998},
Key = {fds138399}
}
@article{fds138400,
Title = {9. Barefoot, J.C., Maynard, K.E., Beckham, J.C., Brummett,
B.H., Hooker, K., & Siegler, I.C. (1998). Trust, Health, and
Longevity. Journal of Behavioral Medicine, 21,
517-526.},
Year = {1998},
Key = {fds138400}
}
@article{fds138401,
Title = {Chapters:},
Year = {1998},
Key = {fds138401}
}
@article{fds138402,
Title = {1. Siegler, I.C. (1998). Alzheimer's disease: Impact in
women. In E. Blechman & K. Brownell (Eds.), Behavioral
medicine for women: A comprehensive handbook (pp. 551-553).
New York: Guilford Press.},
Year = {1998},
Key = {fds138402}
}
@article{fds138403,
Title = {5. Siegler, I.C., Bastian, L.A., & Bosworth, H.B. (in
press). Health, behavior, and aging. In A. Baum, T.R.
Revenson, & J.E. Singer (Eds.), Handbook of health
psychology. Hillsdale, NJ: Erlbaum.},
Year = {1998},
Key = {fds138403}
}
@article{fds138404,
Title = {1/13/99},
Year = {1998},
Key = {fds138404}
}
@article{fds138442,
Title = {1. Bosworth, H.B, Bastian, L.A., & Siegler, I.C. (1998).
Benefits and drawbacks to hormone replacement therapy use
among nursing home patients. Women's Health Issues, 8,
53-59.},
Year = {1998},
Key = {fds138442}
}
@article{fds138443,
Title = {3. Exline, J.L., Siegler, I.C., & Bastian, L.A. (1998).
Differences in providers' beliefs about the benefits and
risks of hormone replacement therapy in managed care.
Journal of Women's Health, 7, 879-884.},
Year = {1998},
Key = {fds138443}
}
@article{fds138444,
Title = {5. Clark, L.M., McDonald, W.M., Welsh-Bohmer, K.A., Siegler,
I.C., Dawson, D.V., Tupler, L.A., & Krishnan, R.R. (1998).
Magnetic resonance imaging correlates of depression in
early- and late-onset Alzheimer's disease. Biological
Psychiatry, 44, 592-599.},
Year = {1998},
Key = {fds138444}
}
@article{fds138445,
Title = {7. Siegler, I.C., & Vitaliano, P.P. (1998). In search of a
double paradigm: Introduction to Special Section on Aging
and Health. Health Psychology, 17, 483-485.},
Year = {1998},
Key = {fds138445}
}
@article{fds138446,
Title = {8. Vitaliano, P.P., Scanlan, J.M., Ochs, H.D., Syrjala, K.,
Siegler, I.C., & Snyder, E.A. (1998). Psychosocial stress
moderates the relationship of cancer history with natural
killer cell activity. Annals of Behavioral Medicine 20,
1-11.},
Year = {1998},
Key = {fds138446}
}
@article{fds138447,
Title = {10. Brummett, B.H., Babyak, M.A., Barefoot, J.C., Bosworth,
H.B., Clapp-Channing, N.E., Siegler, I.C., Williams, Jr.,
R.B., & Mark, D.B. (1998). Social support, hostility and
depressive symptoms in cardiac patients one month following
hospitalization: A Prospective study. Psychosomatic
Medicine, 60, 707-713.},
Year = {1998},
Key = {fds138447}
}
@article{fds138448,
Title = {11. Brummett, B.H., Maynard, K.E., Babyak, M.A., Haney,
T.L., Siegler, I.C., Helms, M.J., & Barefoot, J.C. (in
press). Measures of hostility as predictors of facial affect
during social interaction: Evidence for construct validity.
Annals of Behavioral Medicine.},
Year = {1998},
Key = {fds138448}
}
@article{fds138449,
Title = {12. Von Dras, D. D., Siegler, I. C., Barefoot, J. C.,
Williams, R. B. & Mark D. B. (in press) Coronary
catherization patient and wife's perception of social
support: Effects due to characteristics of recipient,
provider and their interaction. International Journal of
Aging and Human Development.},
Year = {1998},
Key = {fds138449}
}
@article{fds138450,
Title = {2. Bastian, L.A., Couchman, G., Rimer, B.K., McBride, C.M.,
Sutton, L., & Siegler, I.C. (1998). Promoting informed
decision making: Hormone replacement therapy. In C. Bennett
(Ed.), Cancer policy: Cancer treatment and research (pp.
129-147). Norwell, MA: Kluwer Academic Publishers.},
Year = {1998},
Key = {fds138450}
}
@article{fds138451,
Title = {3. Siegler, I.C., Kaplan, B.H., Von Dras, D.D., & Mark D.B.
(1999). Cardiovascular health: A challenge for midlife. In
S. Willis & J. Reid (Eds.), Life in the middle (pp.
147-157). San Diego, CA: Academic Press.},
Year = {1998},
Key = {fds138451}
}
@article{fds138452,
Title = {4. Costa, P.T., McCrae, R.R., & Siegler, I.C. (1999).
Continuity and change over the adult life cycle: Personality
and personality disorders. In C.R. Cloninger (Ed.),
Personality and psychopathology (pp. 129-153). Washington,
DC: American Psychiatric Press.},
Year = {1998},
Key = {fds138452}
}
@article{fds138453,
Title = {6. Siegler, I.C. & K.A. Matthews. (in press). Introduction
to aging and health. In S.H. Qualls & R. Abeles (Eds.),
Dialogues on psychology and aging. Washington, DC: American
Psychiatric Press.},
Year = {1998},
Key = {fds138453}
}
@article{fds138454,
Title = {7. Siegler, I.C. (in press). Aging and health from the aging
point of view. S.H. Qualls & N. Abeles (Eds.), Diaglogues on
psychology and aging. Washington, DC: American Psychological
Association.},
Year = {1998},
Key = {fds138454}
}
@article{fds138392,
Title = {Von Dras, D.D., Siegler, I.C., Williams, Jr., R.B.,
Clapp-Channing, N., Haney, T., & Mark, D.B. (1997).
Surrogate assessment of coronary artery disease patients'
functional capacity. Social Science & Medicine, 44,
1491-1502.},
Year = {1997},
Key = {fds138392}
}
@article{fds138393,
Title = {Bosworth, H.B, Bastian, L.A., & Siegler, I.C. (in press).
Benefits and drawbacks to hormone replacement therapy use
among nursing home patients. Women's Health
Issues.},
Year = {1997},
Key = {fds138393}
}
@article{fds138394,
Title = {Chapters:},
Year = {1997},
Key = {fds138394}
}
@article{fds138395,
Title = {Siegler, I.C. (1997). Promoting health and minimizing
stress. In M.E. Lachman & J. James (Eds.), Multiple paths of
midlife development, (pp. 243-255). Chicago, IL: University
of Chicago Press.},
Year = {1997},
Key = {fds138395}
}
@article{fds138396,
Title = {Siegler, I.C., Kaplan, B.H., Von Dras, D.D., & Mark D.B. (in
press). Cardiovascular health: A challenge for midlife. In
S. Willis & J. Reid (Eds.), Middle aging: Development in the
third quarter of life. Orlando, FL: Academic
Press.},
Year = {1997},
Key = {fds138396}
}
@article{fds138430,
Title = {Siegler, I.C., Blumenthal, J.A., Barefoot, J.C., Peterson,
B.L., Saunders, W.B., Dahlstrom, W.G., Costa Jr., P.T.,
Suarez, E.C., Helms, M.J., Maynard, K.E., & Williams, R.B.
(1997). Personality factors differentially predict exercise
behavior in men and women. Women's Health: Research on
Gender, Behavior and Policy, 3, 61-70.},
Year = {1997},
Key = {fds138430}
}
@article{fds138431,
Title = {Von Dras, D.D. & Siegler, I.C. (1997). Stability in
extraversion and aspects of social support at mid-life.
Journal of Personality and Social Psychology, 72,
233-241.},
Year = {1997},
Key = {fds138431}
}
@article{fds138432,
Title = {Williams, R.B., Barefoot, J.C., Blumenthal, J.A., Helms,
M.J., Luecken, L., Pieper, C.F., Siegler, I.C., & Suarez,
E.C. (1997). Psychosocial correlates of job strain in a
sample of working women. Archives of General Psychiatry, 11,
36-42.},
Year = {1997},
Key = {fds138432}
}
@article{fds138433,
Title = {Szczepanski, R., Napolitano, M., Feaganes, J.R., Kuhn, C.,
Swoap, R., Suarez, E.C., Barefoot, J.C., Siegler, I.C.,
Williams, R.B., & Blumenthal, J.A. (1997). Relation of mood
ratings and neurohormonal responses during daily life in
employed females. International Journal of Behavioral
Medicine, 4, 1-16.},
Year = {1997},
Key = {fds138433}
}
@article{fds138434,
Title = {Luecken, L.J., Suarez, E.C., Kuhn, C.M., Barefoot, J.C.,
Blumenthal, J. A., Siegler, I.C., & Williams, R.B. (1997).
Stress and employed women. I. Impact of marital status and
children at home on neurohormone output and home strain.
Psychosomatic Medicine, 59, 352-359.},
Year = {1997},
Key = {fds138434}
}
@article{fds138435,
Title = {Bastian, L.A., Couchman, G.M., Rimer, B.K., McBride, C.M.,
Feaganes, J.R., & Siegler, I.C. (1997). Perceptions of
menopausal stage and patterns of hormone replacement therapy
use. Journal of Women's Health, 6, 467-475},
Year = {1997},
Key = {fds138435}
}
@article{fds138436,
Title = {Bastian, L.A., Couchman, G.M., Nanda, K., & Siegler, I.C.
(in press). Hormone replacement therapy: Benefits, risks and
management. In Appleby & Montella (Eds.) Clinic Atlas on
Office Gynecology. Philadelphia: WB Saunders
Company},
Year = {1997},
Key = {fds138436}
}
@article{fds138437,
Title = {Vitaliano, P.P., Scanlan, J.M., Ochs, H.D., Syrjala, K.,
Siegler, I.C., & Snyder, E.A. (in press). Psychosocial
stress moderates the relationship of cancer history with
natural killer cell activity. Annals of Behavioral
Medicine.},
Year = {1997},
Key = {fds138437}
}
@article{fds138438,
Title = {Siegler, I.C. (1997). The role of physical health in
understand societal mechanisms for maintaining competence in
old age. In S. Willis, K.W. Schaie, & M. Hayward (Ed.),
Societal mechanisms for maintaining competence in old age,
(pp. 131-135). New York: Springer Publishing
Company.},
Year = {1997},
Key = {fds138438}
}
@article{fds138439,
Title = {Siegler, I.C. (1997). Alzheimer's disease: Impact in women.
In E. Blechman & K. Brownell (Eds.), Behavioral medicine for
women: A comprehensive handbook, PP 551-553. New York:
Guilford Press.},
Year = {1997},
Key = {fds138439}
}
@article{fds138440,
Title = {Costa, P.T., McCrae, R.R., & Siegler, I.C. (in press).
Continuity and change over the adult life cycle: Personality
and personality disorders. In C.R. Cloninger (Ed.),
Personality and psychopathology. Washington, DC: American
Psychiatric Press.},
Year = {1997},
Key = {fds138440}
}
@article{fds138441,
Title = {Bastian, L.A., Couchman, G., Rimer, B.K., McBride, C.M.,
Sutton, L., & Siegler, I.C. (in press). Hormonal replacement
therapy and informed-decision making about cancer risks. In
C. Bennett (Ed.), Cancer policy: Cancer treatment and
research. Norwell, MA.: Kluwer Academic Publishers.},
Year = {1997},
Key = {fds138441}
}
@article{fds138388,
Title = {Dawson, D.V. & Siegler, I.C. (1996). Approaches to the
nonparametric analysis of limited longitudinal data sets.
Experimental Aging Research, 22, 33-57.},
Year = {1996},
Key = {fds138388}
}
@article{fds138389,
Title = {Morton, E., Tambor, E., Rimer, B.K., Tessaro, I., Farrell,
D., & Siegler, I.C. (1996). Impact of National Cancer
Institute revised mammography screening guidelines on women
40-49. Women's Health Issues, 6, 246-254.},
Year = {1996},
Key = {fds138389}
}
@article{fds138390,
Title = {Chapters:},
Year = {1996},
Key = {fds138390}
}
@article{fds138391,
Title = {Keefe, F.J., Beaupre, P., Weiner, D., & Siegler, I.C.
(1996). Pain in older adults: A cognitive-behavioral
perspective. In B.R. Ferrell & B. Ferrell (Eds.), Pain in
the elderly, (pp. 11-19). Seattle, WA: IASP
Press.},
Year = {1996},
Key = {fds138391}
}
@article{fds138424,
Title = {Siegler, I.C., Feaganes, J.R., & Rimer, B.K. (1996).
Awareness of and responses to changes in the National Cancer
Institute's guidelines for mammography in women aged 35-49.
Journal of Women's Health, 5, 33-41.},
Year = {1996},
Key = {fds138424}
}
@article{fds138425,
Title = {Lipkus, I.M., Dalbert, C., & Siegler, I.C. (1996). The
importance of distinguishing the belief in a just world for
self versus others: Implications for psychological
well-being. Personality and Social Psychology Bulletin, 22,
666-677.},
Year = {1996},
Key = {fds138425}
}
@article{fds138426,
Title = {Hughes, D.C., Fillenbaum, G.G., Woodbury, M.A., & Siegler,
I.C. (1996). Psychometric characteristics of the mini-mental
state examination in a community populationùA grade of
membership analysisùPart I. International Journal of
Geriatric Psychiatry, II, 439-455.},
Year = {1996},
Key = {fds138426}
}
@article{fds138427,
Title = {Von Dras, D.D., Williams, R.B., Kaplan, B.H., & Siegler,
I.C. (1996). Correlates of perceived social support and
equality of interpersonal relationships at midlife.
International Journal of Aging and Human Development, 43,
199-217.},
Year = {1996},
Key = {fds138427}
}
@article{fds138428,
Title = {Barefoot, J.C., Helms, M.J., Mark, D.B., Blumenthal, J.A.,
Califf, R.M., Haney, T.L ., O'Connor, C.M., Siegler, I.C., &
Williams, R.B. (1996). Depression and long-term mortality
risk in patients with coronary artery disease. American
Journal Cardiology, 78, 613-617.},
Year = {1996},
Key = {fds138428}
}
@article{fds138429,
Title = {Siegler, I.C., Poon, L.W., Madden, D.J., & Welsh, K.A.
(1996). Psychological aspects of normal aging. In E.W. Busse
& D.G. Blazer (Eds.), Textbook of Geriatric psychiatry (pp.
105-127) (2nd ed.). Washington, DC: American Psychiatric
Press.},
Year = {1996},
Key = {fds138429}
}
@article{fds138381,
Title = {Siegler IC, Feaganes JR, Rimer BK: Predictors of adoption of
mammography in women under age 50. Health Psychology 14:
274-278, 1995.},
Year = {1995},
Key = {fds138381}
}
@article{fds138422,
Title = {Lipkus, I.M. & Siegler, I.C. (1995). Do comparative
self-appraisals during young adulthood predict adult
personality? Psychology and Aging, 10, 229-237.},
Year = {1995},
Key = {fds138422}
}
@article{fds138423,
Title = {Siegler, I.C., Feaganes, J.R., & Rimer, B.K. (1995).
Predictors of adoption of mammography in women under age 50.
Health Psychology, 14, 274-278.},
Year = {1995},
Key = {fds138423}
}
@article{fds138384,
Title = {Costa PT, McCrae RR, Siegler IC: Continuity and change over
the adult life course: Personality and personality
disorders. In: Cloninger RC (ed), Personality and
Psychopathology. Washington DC: American Psychiatric Press,
in press.},
Year = {1994},
Key = {fds138384}
}
@article{fds138385,
Title = {Siegler IC: Psychosocial risk factor measurement
methodology. In: Daugherty S (ed), Council on Epidemiology
and Prevention Committee on Criteria and Methods
Bibliography. Dallas: American Heart Association, in
press.},
Year = {1994},
Key = {fds138385}
}
@article{fds138386,
Title = {Siegler IC, Dawson DV, Welsh KA: Caregiver ratings of
personality change in Alzheimer's disease patients: A
replication. Psychology and Aging 9: 464-466,
1994.},
Year = {1994},
Key = {fds138386}
}
@article{fds138387,
Title = {Siegler, I.C., & Costa, P.T. (1994). Personality and breast
cancer screening behaviors. Annals of Behavioral Medicine,
16, 347-351.},
Year = {1994},
Key = {fds138387}
}
@article{fds138413,
Title = {Siegler IC, Dawson DV, Welsh KA: Caregivers ratings of
personality change in Alzheimer's Disease patients: A
replication. Psychology and Aging 9: 464-466,
1994.},
Year = {1994},
Key = {fds138413}
}
@article{fds138417,
Title = {Siegler IC: Hostility and Risk: Demographic and lifestyle
variables. In: Siegman AW, Smith AW (eds), Anger Hostility
and the Heart. Hillsdale, NJ: Lawrence A Earlbaum. pp
199-214, 1994.},
Year = {1994},
Key = {fds138417}
}
@article{fds138418,
Title = {Lipkus IM, Barefoot JC, Williams RB, Siegler IC:
Biopsychosocial factors and impaired quality of life: Risks
for cardiovascular disease in spouse caregivers of persons
with Alzheimer's Disease. In: Abeles RP, Gift HC, Ory MG
(eds), Aging and the Quality of Life. New York: Springer, in
press.},
Year = {1994},
Key = {fds138418}
}
@article{fds138419,
Title = {Lane JD, Pieper CF, Barefoot JC, Williams RB, Siegler IC:
Caffeine and cholestrol: Interactions with hostility.
Psychosomatic Medicine, in press.},
Year = {1994},
Key = {fds138419}
}
@article{fds138420,
Title = {Siegler IC, Costa PT: Personality and breast cancer
screening behaviors. Lipkus IM, Siegler IC: Do comparative
self-appraisals during young adulthood predict adult
personality? Psychology and Aging, in press.},
Year = {1994},
Key = {fds138420}
}
@article{fds138421,
Title = {Lipkus, I.M., Barefoot, J.C., Williams, R.B., & Siegler,
I.C. (1994). Personality measures as predictors of smoking
initiation and cessation. Health Psychology, 13(4),
149-155.},
Year = {1994},
Key = {fds138421}
}
@article{fds138382,
Title = {Barefoot, J.C., Beckham, J.C., Haney, T.L., Siegler, I.C., &
Lipkus, I.M. (1993). Age differences in hostility among
middle aged and older adults. Psychology and Aging, 8(1),
3-9.},
Year = {1993},
Key = {fds138382}
}
@article{fds138383,
Title = {Lipkus, I.M. & Siegler, I.C. (1993). The belief in a just
world and perceptions of discrimination. Journal of
Psychology: Interdisciplinary & Applied, 127(4),
465-474.},
Year = {1993},
Key = {fds138383}
}
@article{fds138414,
Title = {Hooker, K. & Siegler I.C. (1993). Life goals, satisfaction
and self-rated health. Experimental Aging Research, 19,
97-110.},
Year = {1993},
Key = {fds138414}
}
@article{fds138415,
Title = {Zonderman, A.B., Siegler, I.C., Barefoot, J.C., Williams,
R.B., Jr, & Costa, P.T., Jr. (1993). Age and gender
differences in MMPI content scales. Experimental Aging
Research, 19(3), 241-257.},
Year = {1993},
Key = {fds138415}
}
@article{fds138416,
Title = {Frazier, L.D., Hooker, K., & Siegler, I.C. (1993).
Longitudinal studies of aging in social and psychological
gerontology. Reviews in Clinical Gerontology, 3,
415-426.},
Year = {1993},
Key = {fds138416}
}
@article{fds138380,
Title = {Siegler IC, Peterson BL, Barefoot JC, Williams RB: Hostility
during late adolescence predicts coronary risk factors at
midlife. American Journal of Epidemiology 138 (2): 146-154,
1992.},
Year = {1992},
Key = {fds138380}
}
@article{fds138412,
Title = {Siegler IC, Peterson BL, Barefoot JC, Harvin SH, Dahlstrom
WG, Kaplan BH, Costa PT, Williams RB: Using college alumni
populations in epidemiologic research: The UNC Alumni Heart
Study. Journal of Clinical Epidemiology 45 (11): 1243-1250,
1992.},
Year = {1992},
Key = {fds138412}
}
@article{fds138411,
Title = {Siegler IC, Zonderman AB, Barefoot JC, Williams RB, Costa
PT, McCrae RR: Predicting personality from college MMPI
scores: Implications for follow-uyp studies in psychosomatic
medicine. Psychosomatic Medicine 52: 644-652,
1990.},
Year = {1990},
Key = {fds138411}
}
%% Chapters in Books
@misc{fds354605,
Author = {Siegler, IC and Ogle, CM},
Title = {Lifecourse perspective and health},
Pages = {9-11},
Booktitle = {Cambridge Handbook of Psychology, Health and Medicine: Third
Edition},
Year = {2019},
Month = {June},
ISBN = {9780511543579},
Key = {fds354605}
}
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