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| Publications of Bernard F. Fuemmeler :chronological alphabetical combined listing:%% Journal Articles @article{fds272693, Author = {McDuffie, J and Corsino, L and Fuemmeler, BF and Kotch, J and Coeytaux, RR and Murphy, G and Reese, D and Yancy, WS}, Title = {Assessing Barriers and Facilitators to Weight Reduction: A Community's Perspective}, Journal = {Obesity (Silver Spring, Md.)}, Volume = {19}, Pages = {S144-S144}, Year = {2011}, Month = {November}, ISSN = {1930-7381}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000296603100447&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds272693} } @article{fds272694, Author = {Bidwell, LC and Garrett, ME and McClernon, FJ and Fuemmeler, BF and Williams, RB and Ashley-Koch, AE and Kollins, SH}, Title = {Genotype and ADHD symptoms interact to predict adolescents' early smoking experiences in an epidemiological sample}, Journal = {Behavior Genetics}, Volume = {41}, Number = {6}, Pages = {893-893}, Year = {2011}, Month = {November}, ISSN = {0001-8244}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000295326600022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds272694} } @article{fds272688, Author = {Fuemmeler, BF and Pendzich, M and Zucker, N and Ostbye, T}, Title = {Racial Disparities in the Effect of Parental Obesity on Toddler Adiposity}, Journal = {Obesity (Silver Spring, Md.)}, Volume = {17}, Pages = {S237-S237}, Year = {2009}, Month = {November}, ISSN = {1930-7381}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000271237800692&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds272688} } @article{fds272692, Author = {McClernon, FJ and Lutz, A and Kozink, R and Froeliger, B and Martin, CK and Fuemmeler, BF and Westman, EC}, Title = {Does Macronutrient Content Matter? Results of a Preliminary fMRI Study of Visual Food Cue Reactivity}, Journal = {Obesity (Silver Spring, Md.)}, Volume = {17}, Pages = {S174-S175}, Year = {2009}, Month = {November}, ISSN = {1930-7381}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000271237800456&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds272692} } @article{fds272690, Author = {Fuemmeler, BF and Pendzich, MK and Moriarty, L and Street, EE and Lovelady, C and Ostbye, T}, Title = {Parental feeding styles and child eating behaviors correlate with dietary intake and BMI of 2-year old children of overweight mothers}, Journal = {International Journal of Obesity (2005)}, Volume = {32}, Pages = {S183-S183}, Year = {2008}, Month = {May}, ISSN = {0307-0565}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000255820100727&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds272690} } %% Papers Published @article{fds338436, Author = {Do, EK and Zucker, NL and Huang, ZY and Schechter, JC and Kollins, SH and Maguire, RL and Murphy, SK and Hoyo, C and Fuemmeler, BF}, Title = {Associations between imprinted gene differentially methylated regions, appetitive traits and body mass index in children.}, Journal = {Pediatric Obesity}, Volume = {14}, Number = {2}, Pages = {e12454}, Year = {2019}, Month = {February}, url = {http://dx.doi.org/10.1111/ijpo.12454}, Abstract = {BACKGROUND:Knowledge regarding genetic influences on eating behaviours is expanding; yet less is known regarding contributions of epigenetic variation to appetitive traits and body mass index (BMI) in children. OBJECTIVE:The purpose of this study was to explore relationships between methylation at differentially methylated regions (DMRs) of imprinted genes (insulin-like growth factor 2/H19 and Delta-like, Drosophila, homolog 1/maternally expressed gene 3) using DNA extracted from umbilical cord blood leucocytes, two genetically influenced appetitive traits (food responsiveness and satiety responsiveness) and BMI. METHODS:Data were obtained from participants (N = 317; mean age = 3.6 years; SD = 1.8 years) from the Newborn Epigenetic STudy. Conditional process models were implemented to investigate the associations between DMRs of imprinted genes and BMI, and test whether this association was mediated by appetitive traits and birthweight and moderated by sex. RESULTS:Appetitive traits and birthweight did not mediate the relationship between methylation at DMRs. Increased insulin-like growth factor 2 DMR methylation was associated with higher satiety responsiveness. Higher satiety responsiveness was associated with lower BMI. Associations between methylation at DMRs, appetitive traits and BMI differed by sex. CONCLUSIONS:This is one of the first studies to demonstrate associations between epigenetic variation established prior to birth with appetitive traits and BMI in children, providing support for the need to uncover genetic and epigenetic mechanisms for appetitive traits predisposing some individuals to obesity.}, Doi = {10.1111/ijpo.12454}, Key = {fds338436} } @article{fds339667, Author = {Do, EK and Haberstick, BC and Williams, RB and Lessem, JM and Smolen, A and Siegler, IC and Fuemmeler, BF}, Title = {The role of genetic and environmental influences on the association between childhood ADHD symptoms and BMI.}, Journal = {International Journal of Obesity (2005)}, Volume = {43}, Number = {1}, Pages = {33-42}, Year = {2019}, Month = {January}, url = {http://dx.doi.org/10.1038/s41366-018-0236-5}, Abstract = {BACKGROUND/OBJECTIVES:Although childhood attention deficit hyperactivity disorder (ADHD) has been previously associated with concurrent and later obesity in adulthood, the etiology of this association remains unclear. The objective of this study is to determine the shared genetic effects of ADHD symptoms and BMI in a large sample of sibling pairs, consider how these shared effects may vary over time, and examine potential sex differences. SUBJECT/METHODS:Sibling pair data were obtained from the National Longitudinal Study of Adolescent to Adult Health (Add Health); childhood ADHD symptoms were reported retrospectively during young adulthood, while three prospective measurements of BMI were available from young adulthood to later adulthood. Cholesky decomposition models were fit to this data using Mx and maximum-likelihood estimation. The twin and sibling sample for these analyses included: 221 monozygotic (MZ) pairs (92 male-male, 139 female-female), 228 dizygotic (DZ) pairs (123 male-male, 105 female-female), 471 full-sibling (FS) pairs (289 male-male, 182 female-female), 106 male-female DZ twin pairs, and 234 male-female FS pairs. RESULTS:The magnitude of the association between childhood ADHD symptoms and BMI changed over time and by sex. The etiological relationship between childhood ADHD symptoms and the three prospective measurements of BMI differed for males and females, such that unique or non-shared environmental influences contributed to the relationship within males and genetic factors contributed to the relationship within females. Specifically, among females, genetic influences on childhood ADHD symptoms were partially shared with those effecting BMI and increased from adolescence to later adulthood (genetic correlation = 0.20 (95% CI: 0.07-0.36) in adolescence and 0.24 (95% CI: 0.10, 0.41) in adulthood). CONCLUSION:Genetic influences on ADHD symptoms in childhood are partially shared with those effecting obesity. However, future research is needed to determine why this association is limited to females.}, Doi = {10.1038/s41366-018-0236-5}, Key = {fds339667} } @article{fds336074, Author = {Do, EK and Prom-Wormley, EC and Fuemmeler, BF and Dick, DM and Kendler, KS and Maes, HH}, Title = {Associations Between Initial Subjective Experiences with Tobacco and Self-Reported Recent Use in Young Adulthood.}, Journal = {Substance Use & Misuse}, Volume = {53}, Number = {14}, Pages = {2291-2298}, Year = {2018}, Month = {December}, url = {http://dx.doi.org/10.1080/10826084.2018.1473435}, Abstract = {Youth tobacco use behaviors are predictive of patterns in adulthood and effect long-term health outcomes. Yet, few studies have examined the effect of initial subjective experiences (ISEs) during first tobacco use, which has been found to be an indicator of individuals. sensitivity to nicotine and vulnerability to dependence.The present study aimed to determine the prevalence of ISEs across a variety of tobacco products, evaluate the factor structure of ISEs by first tobacco product used, and examine the relationship between ISEs and recent (30-day) use of tobacco products across time, using a university sample.Exploratory factor analyses were conducted to identify latent factors present with respect to items measuring ISEs with tobacco, separately by tobacco product (e.g. cigarettes, cigars, hookah, e-cigarettes). Factor scores for positive and negative ISEs were calculated. Multiple logistic regression analyses were conducted to examine associations between ISEs and recent use of each tobacco product, adjusted for age at first use, sex, race/ethnicity, and cohort.ISEs differ by the first tobacco product used. Associations between factor scores for positive and negative ISEs and recent use were found across a variety of tobacco products. Overall, positive ISEs were more strongly associated with recent use, relative to negative ISEs.Further research is needed to identify genetic and biological pathways and social contexts influencing initial subjective experiences with tobacco use, in efforts to delay the initiation for tobacco use and reduce risk for continued use among young adults.}, Doi = {10.1080/10826084.2018.1473435}, Key = {fds336074} } @article{fds339666, Author = {Do, EK and Green, TL and Prom-Wormley, EC and Fuemmeler, BF}, Title = {Social determinants of smoke exposure during pregnancy: Findings from waves 1 & 2 of the Population Assessment of Tobacco and Health (PATH) Study.}, Journal = {Preventive Medicine Reports}, Volume = {12}, Pages = {312-320}, Year = {2018}, Month = {December}, url = {http://dx.doi.org/10.1016/j.pmedr.2018.10.020}, Abstract = {Maternal smoking during pregnancy (MSDP) and secondhand smoke (SHS) exposure are associated with a myriad of negative health effects for both mother and child. However, less is known regarding social determinants for SHS exposure, which may differ from those of maternal smoking during pregnancy (MSDP). To identify social determinants for SHS exposure only, MSDP only, and MSDP and SHS exposure, data were obtained from all pregnant women (18-54 years; N = 726) in waves 1 and 2 of the Population Assessment of Tobacco and Health Study (2014-2015). Multiple logistic regressions were conducted using SAS 9.4. Smoke exposure during pregnancy was common; 23.0% reported SHS exposure only, 6.1% reported MSDP only, and 11.8% reported both SHS exposure and MSDP. Results demonstrate that relationships between smoke exposure during pregnancy and social determinants vary by type of exposure. Women at risk for any smoke exposure during pregnancy include those who are unmarried and allow the use of combustible tobacco products within the home. Those who are at higher risk for SHS exposure include those who are younger in age, and those who are earlier in their pregnancy. Those who are at higher risk for maternal smoking include those with fair/poor mental health status and those who believe that others' view tobacco use more positively. These results suggest the need for implementing more comprehensive policies that promote smoke-free environments. Implementing these strategies have the potential to improve maternal and fetal health outcomes associated with tobacco smoke exposure.}, Doi = {10.1016/j.pmedr.2018.10.020}, Key = {fds339666} } @article{fds339772, Author = {Oliver, JA and Hallyburton, MB and Pacek, LR and Mitchell, JT and Vilardaga, R and Fuemmeler, BF and McClernon, FJ}, Title = {What Do Smokers Want in A Smartphone-Based Cessation Application?}, Journal = {Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco}, Volume = {20}, Number = {12}, Pages = {1507-1514}, Year = {2018}, Month = {November}, url = {http://dx.doi.org/10.1093/ntr/ntx171}, Abstract = {Background:Fueled by rapid technological advances over the past decade, there is growing interest in the use of smartphones to aid in smoking cessation. Hundreds of applications have been developed for this purpose, but little is known about how these applications are accessed and used by smokers or what features smokers believe would be most useful. Purpose:The present study sought to understand the prevalence of smartphone ownership and patterns of use among smokers as well as the perceived utility of various smartphone application features for smoking cessation that are currently in development or already available. Methods:Daily cigarette smokers (n = 224) reported on smartphone ownership, their patterns of smartphone usage, and perceived utility of features. Features were ranked according to perceived utility and differences in both perceived utility and general smartphone use patterns were examined as a function of demographic and smoking-related variables. Results:Most smokers (80.4%) own a smartphone, but experience with smoking cessation applications is extremely rare (6.1%). Ownership and patterns of usage differed as a function of demographic and smoking-related variables. Overall, gain-framed features were rated as most useful, while loss-framed and interpersonal features were rated as least useful. Conclusions:Mobile health interventions have the potential to reach a large number of smokers but are currently underutilized. Additional effort is needed to ensure parity in treatment access. Gain-framed messages may be especially useful for engaging smokers, even if other features ultimately drive treatment effects. Implications:This study describes patterns of smartphone usage among smokers and identifies the smartphone application features smokers believe would be most useful during a quit attempt. Findings indicate which subgroups of smokers are most likely to be reached with mobile health interventions and suggests that inclusion of specific features may be helpful for engaging smokers in the smoking cessation process.}, Doi = {10.1093/ntr/ntx171}, Key = {fds339772} } @article{fds337133, Author = {Gao, L and Liu, X and Millstein, J and Siegmund, KD and Dubeau, L and Maguire, RL and Jim Zhang and J and Fuemmeler, BF and Kollins, SH and Hoyo, C and Murphy, SK and Breton, CV}, Title = {Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes.}, Journal = {Clinical Epigenetics}, Volume = {10}, Number = {1}, Pages = {98}, Year = {2018}, Month = {July}, url = {http://dx.doi.org/10.1186/s13148-018-0532-x}, Abstract = {Epigenetic modifications, including DNA methylation, act as one potential mechanism underlying the detrimental effects associated with prenatal tobacco smoke (PTS) exposure. Methylation in a gene called AXL was previously reported to differ in response to PTS.We investigated the association between PTS and epigenetic changes in AXL and how this was related to childhood asthma phenotypes. We tested the association between PTS and DNA methylation at multiple CpG loci of AXL at birth using Pyrosequencing in two separate study populations, the Children's Health Study (CHS, n = 799) and the Newborn Epigenetic Study (NEST, n = 592). Plasma cotinine concentration was used to validate findings with self-reported smoking status. The inter-relationships among AXL mRNA and miR-199a1 expression, PTS, and AXL methylation were examined. Lastly, we evaluated the joint effects of AXL methylation and PTS on the risk of asthma and related symptoms at age 10 years old.PTS was associated with higher methylation level in the AXL gene body in both CHS and NEST subjects. In the pooled analysis, exposed subjects had a 0.51% higher methylation level in this region compared to unexposed subjects (95% CI 0.29, 0.74; p < 0.0001). PTS was also associated with 21.2% lower expression of miR-199a1 (95% CI - 37.9, - 0.1; p = 0.05), a microRNA known to regulate AXL expression. Furthermore, the combination of higher AXL methylation and PTS exposure at birth increased the risk of recent episodes of bronchitic symptoms in childhood.PTS was associated with methylation level of AXL and the combination altered the risk of childhood bronchitic symptoms.}, Doi = {10.1186/s13148-018-0532-x}, Key = {fds337133} } @article{fds330367, Author = {Sanchez, CE and Barry, C and Sabhlok, A and Russell, K and Majors, A and Kollins, SH and Fuemmeler, BF}, Title = {Maternal pre-pregnancy obesity and child neurodevelopmental outcomes: a meta-analysis.}, Journal = {Obesity Reviews : an Official Journal of the International Association for the Study of Obesity}, Volume = {19}, Number = {4}, Pages = {464-484}, Year = {2018}, Month = {April}, url = {http://dx.doi.org/10.1111/obr.12643}, Abstract = {This review examined evidence of the association between maternal pre-pregnancy overweight/obesity status and child neurodevelopmental outcomes. PubMed and PsycINFO databases were systematically searched for empirical studies published before April 2017 using keywords related to prenatal obesity and children's neurodevelopment. Of 1483 identified papers, 41 were included in the systematic review, and 32 articles representing 36 cohorts were included in the meta-analysis. Findings indicated that compared with children of normal weight mothers, children whose mothers were overweight or obese prior to pregnancy were at increased risk for compromised neurodevelopmental outcomes (overweight: OR = 1.17, 95% CI [1.11, 1.24], I2 = 65.51; obese: OR = 1.51; 95% CI [1.35, 1.69], I2 = 79.63). Pre-pregnancy obesity increased the risk of attention deficit-hyperactivity disorder (OR = 1.62; 95% CI [1.23, 2.14], I2 = 70.15), autism spectrum disorder (OR = 1.36; 95% CI [1.08, 1.70], I2 = 60.52), developmental delay (OR = 1.58; 95% CI [1.39, 1.79], I2 = 75.77) and emotional/behavioural problems (OR = 1.42; 95% CI [1.26, 1.59], I2 = 87.74). Given the current obesity prevalence among young adults and women of childbearing age, this association between maternal obesity during pregnancy and atypical child neurodevelopment represents a potentially high public health burden.}, Doi = {10.1111/obr.12643}, Key = {fds330367} } @article{fds336075, Author = {Dozmorov, MG and Bilbo, SD and Kollins, SH and Zucker, N and Do, EK and Schechter, JC and Zhang, JJ and Murphy, SK and Hoyo, C and Fuemmeler, BF}, Title = {Associations between maternal cytokine levels during gestation and measures of child cognitive abilities and executive functioning.}, Journal = {Brain, Behavior, and Immunity}, Year = {2018}, Month = {March}, url = {http://dx.doi.org/10.1016/j.bbi.2018.03.029}, Abstract = {Preclinical studies demonstrate that environmentally-induced alterations in inflammatory cytokines generated by the maternal and fetal immune system can significantly impact fetal brain development. Yet, the relationship between maternal cytokines during gestation and later cognitive ability and executive function remains understudied. Children (n = 246) were born of mothers enrolled in the Newborn Epigenetic Study - a prospective pre-birth cohort in the Southeastern US. We characterized seven cytokines [IL-1β, IL-4,IL-6, IL-12p70, IL-17A, tumor necrosis factor-α (TNFα), and interferon-γ (IFNγ)] and one chemokine (IL-8) from maternal plasma collected during pregnancy. We assessed children's cognitive abilities and executive functioning at a mean age of 4.5 (SD = 1.1) years. Children's DAS-II and NIH toolbox scores were regressed on cytokines and the chemokine, controlling for maternal age, race, education, body mass index, IQ, parity, smoking status, delivery type, gestational weeks, and child birth weight and sex. Higher IL-12p70 (βIL-12p70 = 4.26, p = 0.023) and IL-17A (βIL-17A = 3.70, p = 0.042) levels were related to higher DAS-II GCA score, whereas higher IL-1β (βIL-1B = -6.07, p = 0.003) was related to lower GCA score. Higher IL-12p70 was related to higher performance on NIH toolbox measures of executive functions related to inhibitory control and attention (βIL-12p70 = 5.20, p = 0.046) and cognitive flexibility (βIL-12p70 = 5.10, p = 0.047). Results suggest that dysregulation in gestational immune activity are associated with child cognitive ability and executive functioning.}, Doi = {10.1016/j.bbi.2018.03.029}, Key = {fds336075} } @article{fds336076, Author = {Lee, C-T and McClernon, FJ and Kollins, SH and Fuemmeler, BF}, Title = {Childhood ADHD Symptoms and Future Illicit Drug Use: The Role of Adolescent Cigarette Use.}, Journal = {Journal of Pediatric Psychology}, Volume = {43}, Number = {2}, Pages = {162-171}, Year = {2018}, Month = {March}, url = {http://dx.doi.org/10.1093/jpepsy/jsx098}, Abstract = {The aim of this study is to understand how early cigarette use might predict subsequent illicit drug use, especially among individuals with attention-deficit hyperactivity disorder (ADHD) symptoms during childhood.Data were drawn from the National Longitudinal Study of Adolescent Health (Waves I-IV). The analysis sample involves participants who had not used illicit drugs at Wave I, with no missing responses for studied predictors (N = 7,332).Smoking status at Wave I (ever regular vs. never regular) and childhood ADHD symptoms predicted subsequent illicit drug use at Waves II to IV. No interaction effect of smoking status at Wave I and childhood ADHD symptoms was found. However, an indirect effect from childhood ADHD symptoms on illicit drug use was identified, through smoking status at Wave I. Similar results were observed for predicting illicit drug dependence.The findings support the notion that smoking status during early adolescence may mediate the association between childhood ADHD symptoms and risk of later adult drug use. Interventions to prevent smoking among adolescents may be particularly effective at decreasing subsequent drug use, especially among children with ADHD symptoms.}, Doi = {10.1093/jpepsy/jsx098}, Key = {fds336076} } @article{fds333723, Author = {Van Voorhees and EE and Dennis, PA and Elbogen, EB and Fuemmeler, B and Neal, LC and Calhoun, PS and Beckham, JC}, Title = {Characterizing anger-related affect in individuals with posttraumatic stress disorder using ecological momentary assessment.}, Journal = {Psychiatry Research}, Volume = {261}, Pages = {274-280}, Year = {2018}, Month = {March}, url = {http://dx.doi.org/10.1016/j.psychres.2017.12.080}, Abstract = {This study employed secondary analyses of existing ecological momentary assessment (EMA) data to characterize hostile and irritable affect in the day-to-day experience of 52 smokers with, and 65 smokers without, posttraumatic stress disorder (PTSD). EMA monitoring occurred over a mean of 8.2 days, and participants responded to an average of 2.8 random prompts/day. Analyses included Wilcoxon rank sum tests of group differences, and path analyses of cross-lagged multilevel models. Participants with PTSD endorsed a significantly higher proportion of total EMA entries indicating hostile affect and irritable affect than did individuals without PTSD. Cross-lagged analyses indicated that over a period of hours, PTSD symptoms significantly predicted subsequent hostile and irritable affect, but hostile and irritable affect did not predict subsequent PTSD symptoms. Findings suggest that day-to-day exposure to PTSD-related trauma cues may contribute to chronically elevated levels of anger-related affect. Such heightened affective arousal may, in turn, underlie an increased risk for verbal or physical aggression, as well as other health and quality-of-life related impairments associated with PTSD. Clinical implications include conceptualizing anger treatment in the broader context of trauma history and symptoms, and specifically targeting physiological arousal and maladaptive hostile cognitions triggered by trauma reminders in patients with PTSD.}, Doi = {10.1016/j.psychres.2017.12.080}, Key = {fds333723} } @article{fds333243, Author = {Cates, JR and Fuemmeler, BF and Diehl, SJ and Stockton, LL and Porter, J and Ihekweazu, C and Gurbani, AS and Coyne-Beasley, T}, Title = {Developing a Serious Videogame for Preteens to Motivate HPV Vaccination Decision Making: Land of Secret Gardens.}, Journal = {Games for Health Journal}, Volume = {7}, Number = {1}, Pages = {51-66}, Year = {2018}, Month = {February}, url = {http://dx.doi.org/10.1089/g4h.2017.0002}, Abstract = {INTRODUCTION:Vaccination against human papillomavirus (HPV) is routinely recommended for ages 11-12, yet in 2016 only 49.5% of women and 37.5% of men had completed the three-dose series in the United States. Offering information and cues to action through a serious videogame for preteens may foster HPV vaccination awareness, information seeking, and communication. MATERIALS AND METHODS:An iterative process was used to develop an interactive videogame, Land of Secret Gardens. Three focus groups were conducted with 16 boys and girls, ages 11-12, for input on game design, acceptability, and functioning. Two parallel focus groups explored parents' (n = 9) perspectives on the game concept. Three researchers identified key themes. RESULTS:Preteens wanted a game that is both entertaining and instructional. Some parents were skeptical that games could be motivational. A back-story about a secret garden was developed as a metaphor for a preteen's body and keeping it healthy. The goal is to plant a lush secret garden and protect the seedlings by treating them with a potion when they sprout to keep them healthy as they mature. Points to buy seeds and create the potion are earned by playing mini-games. Throughout play, players are exposed to messaging about HPV and the benefits of the vaccine. Both boys and girls liked the garden concept and getting facts about HPV. Parents were encouraged to discuss the game with their preteens. CONCLUSION:Within a larger communication strategy, serious games could be useful for engaging preteens in health decision making about HPV vaccination.}, Doi = {10.1089/g4h.2017.0002}, Key = {fds333243} } @article{fds331558, Author = {Schechter, JC and Fuemmeler, BF and Hoyo, C and Murphy, SK and Zhang, JJ and Kollins, SH}, Title = {Impact of Smoking Ban on Passive Smoke Exposure in Pregnant Non-Smokers in the Southeastern United States.}, Journal = {International Journal of Environmental Research and Public Health}, Volume = {15}, Number = {1}, Year = {2018}, Month = {January}, url = {http://dx.doi.org/10.3390/ijerph15010083}, Abstract = {Prenatal passive smoke exposure raises risk for negative birth outcomes. Legislation regulating public smoking has been shown to impact exposure levels, though fewer studies involving pregnant women have been conducted within the U.S. where bans are inconsistent across regions. This study examined the effect of a ban enacted in the southeastern U.S. on pregnant women's cotinine levels. Additional analyses compared self-reported exposure to cotinine and identified characteristics associated with passive exposure. Pregnant women (N = 851) were recruited prospectively between 2005 and 2011 in North Carolina. Sociodemographic and health data were collected via surveys; maternal blood samples were assayed for cotinine. Among non-active smokers who provided self-report data regarding passive exposure (N = 503), 20% were inconsistent with corresponding cotinine. Among all non-smokers (N = 668), being unmarried, African American, and less educated were each associated with greater passive exposure. Controlling for covariates, mean cotinine was higher prior to the ban compared to after, F(1, 640) = 24.65, p < 0.001. Results suggest that banning smoking in public spaces may reduce passive smoke exposure for non-smoking pregnant women. These data are some of the first to examine the impact of legislation on passive smoke exposure in pregnant women within the U.S. using a biomarker and can inform policy in regions lacking comprehensive smoke-free legislation.}, Doi = {10.3390/ijerph15010083}, Key = {fds331558} } @article{fds338573, Author = {House, JS and Mendez, M and Maguire, RL and Gonzalez-Nahm, S and Huang, Z and Daniels, J and Murphy, SK and Fuemmeler, BF and Wright, FA and Hoyo, C}, Title = {Periconceptional Maternal Mediterranean Diet Is Associated With Favorable Offspring Behaviors and Altered CpG Methylation of Imprinted Genes.}, Journal = {Frontiers in Cell and Developmental Biology}, Volume = {6}, Pages = {107}, Year = {2018}, Month = {January}, url = {http://dx.doi.org/10.3389/fcell.2018.00107}, Abstract = {Background: Maternal diet during pregnancy has been shown to influence the child neuro-developmental outcomes. Studies examining effects of dietary patterns on offspring behavior are sparse. Objective: Determine if maternal adherence to a Mediterranean diet is associated with child behavioral outcomes assessed early in life, and to evaluate the role of differentially methylated regions (DMRs) regulating genomically imprinted genes in these associations. Methods: Among 325 mother/infant pairs, we used regression models to evaluate the association between tertiles of maternal periconceptional Mediterranean diet adherence (MDA) scores derived from a Food Frequency Questionnaire, and social and emotional scores derived from the Infant Toddler Social and Emotional Assessment (ITSEA) questionnaire in the second year of life. Methylation of nine genomically imprinted genes was measured to determine if MDA was associated with CpG methylation. Results: Child depression was inversely associated with maternal MDA (Bonferroni-corrected p = 0.041). While controlling for false-discovery, compared to offspring of women with the lowest MDA tertile, those with MDA scores in middle and high MDA tertiles had decreased odds for atypical behaviors [OR (95% CI) = 0.40 (0.20, 0.78) for middle and 0.40 (0.17, 0.92) for highest tertile], for maladaptive behaviors [0.37 (0.18, 0.72) for middle tertile and 0.42 (0.18, 0.95) for highest tertile] and for an index of autism spectrum disorder behaviors [0.46 (0.23, 0.90) for middle and 0.35 (0.15, 0.80) for highest tertile]. Offspring of women with the highest MDA tertile were less likely to exhibit depressive [OR = 0.28 (0.12, 0.64)] and anxiety [0.42 (0.18, 0.97)] behaviors and increased odds of social relatedness [2.31 (1.04, 5.19)] behaviors when compared to low MDA mothers. Some associations varied by sex. Perinatal MDA score was associated with methylation differences for imprinted control regions of PEG10/SGCE [females: Beta (95% CI) = 1.66 (0.52, 2.80) - Bonferroni-corrected p = 0.048; males: -0.56 (-1.13, -0.00)], as well as both MEG3 and IGF2 in males [0.97 (0.00, 1.94)] and -0.92 (-1.65, -0.19) respectively. Conclusion: In this ethnically diverse cohort, maternal adherence to a Mediterranean diet in early pregnancy was associated with favorable neurobehavioral outcomes in early childhood and with sex-dependent methylation differences of MEG3, IGF2, and SGCE/PEG10 DMRs.}, Doi = {10.3389/fcell.2018.00107}, Key = {fds338573} } @article{fds331494, Author = {Chawla, D and Fuemmeler, B and Benjamin-Neelon, SE and Hoyo, C and Murphy, S and Daniels, JL}, Title = {Early prenatal vitamin D concentrations and social-emotional development in infants.}, Journal = {The Journal of Maternal Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians}, Pages = {1-8}, Year = {2017}, Month = {December}, url = {http://dx.doi.org/10.1080/14767058.2017.1408065}, Abstract = {Many pregnant women in the United States have suboptimal vitamin D, but the impact on infant development is unclear. Moreover, no pregnancy-specific vitamin D recommendations have been widely accepted.Given the ubiquitous expression of vitamin D receptors in the brain, we investigated the association between early prenatal plasma 25-hydroxyvitamin D (25(OH)D) concentrations and children's social and emotional development in the Newborn Epigenetic Study, a prospective study of pregnancies from 2009 to 2011 in Durham, North Carolina.We measured 25(OH)D concentrations in first or second trimester plasma samples and categorized 25(OH)D concentrations into quartiles. Covariates were derived from maternal questionnaires. Mothers completed the Infant Toddler Social-Emotional Development Assessment when children were 12-24 months of age. We used multivariable linear regression to evaluate associations between 25(OH)D and specific behavior scores, adjusted for season of blood draw, maternal age, education, parity, smoking, marital status, prepregnancy BMI, and infant gender. We investigated effect-measure modification by race/ethnicity.Of the 218 mother-infant pairs with complete data, Black mothers had much lower 25(OH)D concentrations as compared to White and Hispanic mothers. After adjustment, lower prenatal 25(OH)D was associated with slightly higher (less favorable) Internalizing scores among White children, but lower (more favorable) Internalizing scores among Black and Hispanic children. Lower prenatal 25(OH)D also appears to be associated with higher (less favorable) dysregulation scores, though only among White and Hispanic children.Though imprecise, preliminary results warrant further investigation regarding a role for prenatal vitamin D on children's early social and emotional development.}, Doi = {10.1080/14767058.2017.1408065}, Key = {fds331494} } @article{fds329030, Author = {McCullough, LE and Miller, EE and Calderwood, LE and Shivappa, N and Steck, SE and Forman, MR and A Mendez and M and Maguire, R and Fuemmeler, BF and Kollins, SH and D Bilbo and S and Huang, Z and Murtha, AP and Murphy, SK and Hébert, JR and Hoyo, C}, Title = {Maternal inflammatory diet and adverse pregnancy outcomes: Circulating cytokines and genomic imprinting as potential regulators?}, Journal = {Epigenetics}, Volume = {12}, Number = {8}, Pages = {688-697}, Year = {2017}, Month = {August}, url = {http://dx.doi.org/10.1080/15592294.2017.1347241}, Abstract = {Excessive inflammation during pregnancy alters homeostatic mechanisms of the developing fetus and has been linked to adverse pregnancy outcomes. An anti-inflammatory diet could be a promising avenue to combat the pro-inflammatory state of pregnancy, particularly in obese women, but we lack mechanistic data linking this dietary pattern during pregnancy to inflammation and birth outcomes. In an ethnically diverse cohort of 1057 mother-child pairs, we estimated the relationships between dietary inflammatory potential [measured via the energy-adjusted dietary inflammatory index (E-DII™)] and birth outcomes overall, as well as by offspring sex and maternal pre-pregnancy body mass index (BMI). In a subset of women, we also explored associations between E-DII, circulating cytokines (n = 105), and offspring methylation (n = 338) as potential modulators of these relationships using linear regression. Adjusted regression models revealed that women with pro-inflammatory diets had elevated rates of preterm birth among female offspring [β = -0.22, standard error (SE) = 0.07, P<0.01], but not male offspring (β=0.09, SE = 0.06, P<0.12) (Pinteraction = 0.003). Similarly, we observed pro-inflammatory diets were associated with higher rates of caesarean delivery among obese women (β = 0.17, SE = 0.08, P = 0.03), but not among women with BMI <25 kg/m2 (Pinteraction = 0.02). We observed consistent inverse associations between maternal inflammatory cytokine concentrations (IL-12, IL-17, IL-4, IL-6, and TNFα) and lower methylation at the MEG3 regulatory sequence (P<0.05); however, results did not support the link between maternal E-DII and circulating cytokines. We replicate work by others on the association between maternal inflammatory diet and adverse pregnancy outcomes and provide the first empirical evidence supporting the inverse association between circulating cytokine concentrations and offspring methylation.}, Doi = {10.1080/15592294.2017.1347241}, Key = {fds329030} } @article{fds326256, Author = {Fuemmeler, BF and Behrman, P and Taylor, M and Sokol, R and Rothman, E and Jacobson, LT and Wischenka, D and Tercyak, KP}, Title = {Child and family health in the era of prevention: new opportunities and challenges.}, Journal = {Journal of Behavioral Medicine}, Volume = {40}, Number = {1}, Pages = {159-174}, Year = {2017}, Month = {February}, url = {http://dx.doi.org/10.1007/s10865-016-9791-1}, Abstract = {To maintain positive health outcomes over the life course, prevention efforts should begin early in childhood. Two research domains that significantly impact the trajectory of health over the life course are childhood obesity and early trauma and violence. Prevention strategies addressing multiple levels of influence are being adopted in these fields. Childhood obesity prevention efforts no longer focus solely on individuals, but embrace multiple ecological levels, such as family, school, and community. Similarly, research on early trauma and violence has broadened to consider risk and protective factors across domains of influence. Although we have improved our understanding and prevention of these two issues, gaps remain in research, practice, and policy. The purpose of this review is to relay relevant findings that could enhance prevention strategies. We describe early life and multilevel risk factors relevant to these areas of research. We also provide recommendations for future efforts to better ensure good health for generations to come.}, Doi = {10.1007/s10865-016-9791-1}, Key = {fds326256} } @article{fds325524, Author = {Fuemmeler, BF and Wang, L and Iversen, ES and Maguire, R and Murphy, SK and Hoyo, C}, Title = {Association between Prepregnancy Body Mass Index and Gestational Weight Gain with Size, Tempo, and Velocity of Infant Growth: Analysis of the Newborn Epigenetic Study Cohort.}, Journal = {Childhood Obesity}, Volume = {12}, Number = {3}, Pages = {210-218}, Year = {2016}, Month = {June}, url = {http://dx.doi.org/10.1089/chi.2015.0253}, Abstract = {The first 1000 days of life is a critical period of infant growth that has been linked to future adult health. Understanding prenatal factors that contribute to variation in growth during this period could inform successful prevention strategies.Prenatal and maternal characteristics, including prepregnancy obesity and gestational weight gain were evaluated in relation to weight growth trajectories during the first 24 months of life using the SuperImposition by Translation and Rotation (SITAR) method, which provides estimates of infant size, timing to peak velocity, and growth velocity. The study sample included 704 mother-infant dyads from a multiethnic prebirth cohort from the Southeastern United States. The total number of weight measures was 8670 (median number per child = 14).Several prenatal and maternal characteristics were linked with infant growth parameters. The primary findings show that compared to women with a prepregnancy BMI between 18 and 24.9, women with a prepregnancy BMI ≥40 had infants that were 8% larger during the first 24 months, a delayed tempo of around 9 days, and a slower velocity. Mothers who had greater than adequate gestational weight gain had infants that were 5% larger even after controlling for prepregnancy BMI and several other covariates.The findings contribute new data on the associations between gestational weight gain and aspects of early growth using the SITAR method, and support a growing consensus in the literature that both prepregnancy BMI and gestational weight gain relate independently to risk for greater postnatal weight growth.}, Doi = {10.1089/chi.2015.0253}, Key = {fds325524} } @article{fds315008, Author = {Joubert, BR and Felix, JF and Yousefi, P and Bakulski, KM and Just, AC and Breton, C and Reese, SE and Markunas, CA and Richmond, RC and Xu, C-J and Küpers, LK and Oh, SS and Hoyo, C and Gruzieva, O and Söderhäll, C and Salas, LA and Baïz, N and Zhang, H and Lepeule, J and Ruiz, C and Ligthart, S and Wang, T and Taylor, JA and Duijts, L and Sharp, GC and Jankipersadsing, SA and Nilsen, RM and Vaez, A and Fallin, MD and Hu, D and Litonjua, AA and Fuemmeler, BF and Huen, K and Kere, J and Kull, I and Munthe-Kaas, MC and Gehring, U and Bustamante, M and Saurel-Coubizolles, MJ and Quraishi, BM and Ren, J and Tost, J and Gonzalez, JR and Peters, MJ and Håberg, SE and Xu, Z and van Meurs, JB and Gaunt, TR and Kerkhof, M and Corpeleijn, E and Feinberg, AP and Eng, C and Baccarelli, AA and Benjamin Neelon and SE and Bradman, A and Merid, SK and Bergström, A and Herceg, Z and Hernandez-Vargas, H and Brunekreef, B and Pinart, M and Heude, B and Ewart, S and Yao, J and Lemonnier, N and Franco, OH and Wu, MC and Hofman, A and McArdle, W and Van der Vlies and P and Falahi, F and Gillman, MW and Barcellos, LF and Kumar, A and Wickman, M and Guerra, S and Charles, M-A and Holloway, J and Auffray, C and Tiemeier, HW and Smith, GD and Postma, D and Hivert, M-F and Eskenazi, B and Vrijheid, M and Arshad, H and Antó, JM and Dehghan, A and Karmaus, W and Annesi-Maesano, I and Sunyer, J and Ghantous, A and Pershagen, G and Holland, N and Murphy, SK and DeMeo, DL and Burchard, EG and Ladd-Acosta, C and Snieder, H and Nystad, W and Koppelman, GH and Relton, CL and Jaddoe, VWV and Wilcox, A and Melén, E and London, SJ}, Title = {DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis.}, Journal = {American Journal of Human Genetics}, Volume = {98}, Number = {4}, Pages = {680-696}, Year = {2016}, Month = {April}, ISSN = {0002-9297}, url = {http://dx.doi.org/10.1016/j.ajhg.2016.02.019}, Abstract = {Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an important public health problem that impacts child health in a myriad of ways and has potential lifelong consequences. The mechanisms are largely unknown, but epigenetics most likely plays a role. We formed the Pregnancy And Childhood Epigenetics (PACE) consortium and meta-analyzed, across 13 cohorts (n = 6,685), the association between maternal smoking in pregnancy and newborn blood DNA methylation at over 450,000 CpG sites (CpGs) by using the Illumina 450K BeadChip. Over 6,000 CpGs were differentially methylated in relation to maternal smoking at genome-wide statistical significance (false discovery rate, 5%), including 2,965 CpGs corresponding to 2,017 genes not previously related to smoking and methylation in either newborns or adults. Several genes are relevant to diseases that can be caused by maternal smoking (e.g., orofacial clefts and asthma) or adult smoking (e.g., certain cancers). A number of differentially methylated CpGs were associated with gene expression. We observed enrichment in pathways and processes critical to development. In older children (5 cohorts, n = 3,187), 100% of CpGs gave at least nominal levels of significance, far more than expected by chance (p value < 2.2 × 10(-16)). Results were robust to different normalization methods used across studies and cell type adjustment. In this large scale meta-analysis of methylation data, we identified numerous loci involved in response to maternal smoking in pregnancy with persistence into later childhood and provide insights into mechanisms underlying effects of this important exposure.}, Doi = {10.1016/j.ajhg.2016.02.019}, Key = {fds315008} } @article{fds325525, Author = {Fuemmeler, BF and Lee, C-T and Soubry, A and Iversen, ES and Huang, Z and Murtha, AP and Schildkraut, JM and Jirtle, RL and Murphy, SK and Hoyo, C}, Title = {DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament.}, Journal = {Genetics & Epigenetics}, Volume = {8}, Pages = {59-67}, Year = {2016}, Month = {January}, url = {http://dx.doi.org/10.4137/GEG.S40538}, Abstract = {DNA methylation of the differentially methylated regions (DMRs) of imprinted genes is relevant to neurodevelopment.DNA methylation status of the DMRs of nine imprinted genes in umbilical cord blood leukocytes was analyzed in relation to infant behaviors and temperament (n = 158).MEG3 DMR levels were positively associated with internalizing (β = 0.15, P = 0.044) and surgency (β = 0.19, P = 0.018) behaviors, after adjusting for birth weight, gender, gestational age at birth, maternal age at delivery, race/ethnicity, education level, smoking status, parity, and a history of anxiety or depression. Higher methylation levels at the intergenic MEG3-IG methylation regions were associated with surgency (β = 0.28, P = 0.0003) and PEG3 was positively related to externalizing (β = 0.20, P = 0.01) and negative affectivity (β = 0.18, P = 0.02).While the small sample size limits inference, these pilot data support gene-specific associations between epigenetic differences in regulatory regions of imprinted domains at birth and later infant temperament.}, Doi = {10.4137/GEG.S40538}, Key = {fds325525} } @article{fds300029, Author = {Daniel, CL and Emmons, KM and Fasciano, K and Fuemmeler, BF and Demark-Wahnefried, W}, Title = {Needs and Lifestyle Challenges of Adolescents and Young Adults With Cancer: Summary of an Institute of Medicine and Livestrong Foundation Workshop.}, Journal = {Clinical Journal of Oncology Nursing}, Volume = {19}, Number = {6}, Pages = {675-681}, Year = {2015}, Month = {December}, ISSN = {1092-1095}, url = {http://dx.doi.org/10.1188/15.CJON.19-06AP}, Abstract = {Among adolescents and young adults (AYAs) in the United States, cancer is the leading cause of disease-related death. AYA survivors face numerous short- and long-term health and psychosocial issues, as well as increased risk for behavioral and lifestyle challenges, including poor diet, low physical activity (PA), and substance abuse. Many of these behaviors are modifiable, but gaps in care serve as barriers for AYA survivors.The purpose of this article is to (a) raise awareness of AYAs' increased risk for poor diet, low PA, and substance abuse; (b) examine previous interventions addressing these issues; and (c) provide recommendations for future directions.This article summarizes a workshop coordinated by the Institute of Medicine and the Livestrong Foundation to address AYA survivors' needs and ways to enhance their quality of care.Oncology nurses can promote the inclusion of lifestyle behaviors in survivorship care plans of AYA patients and serve as a valuable resource in improving AYA care on a larger scale. In addition, oncology nurse researchers may offer greater understanding of AYA patients' and survivors' needs and best practices by conducting much-needed research with this understudied population.}, Doi = {10.1188/15.CJON.19-06AP}, Key = {fds300029} } @article{fds272663, Author = {Fuemmeler, BF and Stroo, M and Lee, C-T and Bazemore, S and Blocker, B and Østbye, T}, Title = {Racial Differences in Obesity-Related Risk Factors Between 2-Year-Old Children Born of Overweight Mothers.}, Journal = {Journal of Pediatric Psychology}, Volume = {40}, Number = {7}, Pages = {649-656}, Year = {2015}, Month = {August}, ISSN = {0146-8693}, url = {http://dx.doi.org/10.1093/jpepsy/jsv023}, Abstract = {Investigate racial differences in a range of obesity-related socio-behavioral risk factors in children born of obese mothers.142 Black and 151 White 2-year-old children and their parents were surveyed on their physical activity environment, food environment, parental role modeling, eating behaviors, feeding practices, child physical activity, dietary intake, and eating behaviors; body mass index (BMI) for parents and children (BMI z-score) were calculated.In bivariate analyses, Black families reported significantly more risk factors for early-childhood obesity than White families, including greater availability of soda, more television viewing, and poorer dietary intake. In multivariate analyses adjusting for maternal and socioeconomic factors, the differences between Black and White families on factors including television watching and dietary intake remained significant.These data show a greater number of risk factors for obesity among Black children and their families compared with White children even after adjustment for maternal BMI and socioeconomic status.}, Doi = {10.1093/jpepsy/jsv023}, Key = {fds272663} } @article{fds272670, Author = {Clark, TT and Yang, C and McClernon, FJ and Fuemmeler, BF}, Title = {Racial differences in parenting style typologies and heavy episodic drinking trajectories.}, Journal = {Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association}, Volume = {34}, Number = {7}, Pages = {697-708}, Year = {2015}, Month = {July}, ISSN = {0278-6133}, url = {http://dx.doi.org/10.1037/hea0000150}, Abstract = {This study examines racial differences between Whites and Blacks in the association of parenting style typologies with changes in heavy episodic drinking from adolescence to young adulthood.The analytic sample consists of 9,942 adolescents drawn from the National Longitudinal Study of Adolescent Health, which followed respondents from ages 12 to 31 years. Confirmatory factor analysis and factor mixture modeling are used to classify parenting style typologies based on measures of parental acceptance and control. Heavy Episodic Drinking (HED) trajectories are evaluated using a zero-inflated Poisson multigroup latent growth curve modeling approach.The mixture model identified 4 heterogeneous groups that differed based on the 2 latent variables (parental acceptance and control): balanced (65.8% of the sample), authoritarian (12.2%), permissive (19.4%), and uninvolved or neglectful (2.7%). Regardless of race, we found that at age 12 years, children of authoritarian parents have a higher probability of not engaging in HED than children of parents with balanced, permissive, or neglectful parenting styles. However, among Black youth who reported HED at age 12, authoritarian parenting was associated with greater level of HED at age 12 but a less steep increase in level of HED as age increased yearly as compared with balanced parenting. For White adolescents, uninvolved, permissive, and authoritarian parenting were not associated with a greater level of HED as age increased yearly as compared with adolescents exposed to balanced parenting.The influence of parenting styles on HED during adolescence persists into young adulthood and differs by race for youth engaging in HED.}, Doi = {10.1037/hea0000150}, Key = {fds272670} } @article{fds272674, Author = {Soubry, A and Murphy, SK and Wang, F and Huang, Z and Vidal, AC and Fuemmeler, BF and Kurtzberg, J and Murtha, A and Jirtle, RL and Schildkraut, JM and Hoyo, C}, Title = {Newborns of obese parents have altered DNA methylation patterns at imprinted genes.}, Journal = {International Journal of Obesity (2005)}, Volume = {39}, Number = {4}, Pages = {650-657}, Year = {2015}, Month = {April}, url = {http://www.ncbi.nlm.nih.gov/pubmed/24158121}, Abstract = {Several epidemiologic studies have demonstrated associations between periconceptional environmental exposures and health status of the offspring in later life. Although these environmentally related effects have been attributed to epigenetic changes, such as DNA methylation shifts at imprinted genes, little is known about the potential effects of maternal and paternal preconceptional overnutrition or obesity.We examined parental preconceptional obesity in relation to DNA methylation profiles at multiple human imprinted genes important in normal growth and development, such as: maternally expressed gene 3 (MEG3), mesoderm-specific transcript (MEST), paternally expressed gene 3 (PEG3), pleiomorphic adenoma gene-like 1 (PLAGL1), epsilon sarcoglycan and paternally expressed gene 10 (SGCE/PEG10) and neuronatin (NNAT).We measured methylation percentages at the differentially methylated regions (DMRs) by bisulfite pyrosequencing in DNA extracted from umbilical cord blood leukocytes of 92 newborns. Preconceptional obesity, defined as BMI ⩾30 kg m(-2), was ascertained through standardized questionnaires.After adjusting for potential confounders and cluster effects, paternal obesity was significantly associated with lower methylation levels at the MEST (β=-2.57; s.e.=0.95; P=0.008), PEG3 (β=-1.71; s.e.=0.61; P=0.005) and NNAT (β=-3.59; s.e.=1.76; P=0.04) DMRs. Changes related to maternal obesity detected at other loci were as follows: β-coefficient was +2.58 (s.e.=1.00; P=0.01) at the PLAGL1 DMR and -3.42 (s.e.=1.69; P=0.04) at the MEG3 DMR.We found altered methylation outcomes at multiple imprint regulatory regions in children born to obese parents, compared with children born to non-obese parents. In spite of the small sample size, our data suggest a preconceptional influence of parental life-style or overnutrition on the (re)programming of imprint marks during gametogenesis and early development. More specifically, the significant and independent association between paternal obesity and the offspring's methylation status suggests the susceptibility of the developing sperm for environmental insults. The acquired imprint instability may be carried onto the next generation and increase the risk for chronic diseases in adulthood.}, Doi = {10.1038/ijo.2013.193}, Key = {fds272674} } @article{fds312815, Author = {Fuemmeler, BF and Davis, AM and Cushing, C and Spruijt-Metz, D and Wearing, JR and Dean, K}, Title = {DEVELOPING DIGITALLY-MEDIATED INTERVENTIONS FOR PREVENTING/TREATING OBESITY IN PEDIATRIC POPULATIONS}, Journal = {Annals of Behavioral Medicine}, Volume = {49}, Pages = {S49-S49}, Year = {2015}, Month = {April}, ISSN = {0883-6612}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000367825001194&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds312815} } @article{fds312816, Author = {Fuemmeler, BF and Hoyo, C and Murphy, S and Vidal, AC and Kollins, SH}, Title = {PRE-PREGNANCY OBESITY AND OFFSPRING NEUROBEHAVIORAL DEVELOPMENT}, Journal = {Annals of Behavioral Medicine}, Volume = {49}, Pages = {S252-S252}, Year = {2015}, Month = {April}, ISSN = {0883-6612}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000367825002480&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds312816} } @article{fds312814, Author = {Fuemmeler, BF}, Title = {MILA CELESTIAL BLOOM: HEALTH PROMOTION AMONG ADOLESCENT CANCER SURVIVORS VIA A SMARTPHONE APP}, Journal = {Annals of Behavioral Medicine}, Volume = {49}, Pages = {S50-S50}, Year = {2015}, Month = {April}, ISSN = {0883-6612}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000367825001195&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds312814} } @article{fds272666, Author = {Lee, C-T and Clark, TT and Kollins, SH and McClernon, FJ and Fuemmeler, BF}, Title = {Attention Deficit Hyperactivity Disorder symptoms and smoking trajectories: race and gender differences.}, Journal = {Drug and Alcohol Dependence}, Volume = {148}, Pages = {180-187}, Year = {2015}, Month = {March}, ISSN = {0376-8716}, url = {http://dx.doi.org/10.1016/j.drugalcdep.2015.01.002}, Abstract = {This study examined the influence of Attention Deficit Hyperactivity Disorder (ADHD) symptoms severity and directionality (hyperactive-impulsive symptoms relative to inattentive symptoms) on trajectories of the probability of current (past month) smoking and the number of cigarettes smoked from age 13 to 32. Racial and gender differences in the relationship of ADHD symptoms and smoking trajectories were also assessed.A subsample of 9719 youth (54.5% female) was drawn from the National Longitudinal Study of Adolescent to Adult Health (Add Health). Cohort sequential design and zero-inflated Poisson (ZIP) latent growth modeling were used to estimate the relationship between ADHD directionality and severity on smoking development.ADHD severity's effect on the likelihood of ever smoking cigarettes at the intercept (age 13) had a greater impact on White males than other groups. ADHD severity also had a stronger influence on the initial number of cigarettes smoked at age 13 among Hispanic participants. The relationships between ADHD directionality (hyperactive-impulsive symptoms relative to inattentive symptoms) and a higher number of cigarettes smoked at the intercept were stronger among Hispanic males than others. Gender differences manifested only among Whites.ADHD severity and directionality had unique effects on smoking trajectories. Our results also highlight that the risk of ADHD symptoms may differ by race and gender.}, Doi = {10.1016/j.drugalcdep.2015.01.002}, Key = {fds272666} } @article{fds272665, Author = {Østbye, T and Stroo, M and Brouwer, RJN and Peterson, BL and Eisenstein, EL and Fuemmeler, BF and Joyner, J and Gulley, L and Dement, JM}, Title = {Steps to Health employee weight management randomized control trial: short-term follow-up results.}, Journal = {Journal of Occupational and Environmental Medicine}, Volume = {57}, Number = {2}, Pages = {188-195}, Year = {2015}, Month = {February}, ISSN = {1076-2752}, url = {http://hdl.handle.net/10161/11443 Duke open access}, Abstract = {To present the short-term follow-up findings of the Steps to Health study, a randomized trial to evaluate the effectiveness of two employee weight management programs offered within Duke University and the Health System.A total of 550 obese (body mass index, ≥30 kg/m2) employees were randomized 1:1 between January 2011 and June 2012 to the education-based Weight Management (WM) or the WM+ arm, which focused on behavior modification. Employees were contacted to complete a follow-up visit approximately 14 months after baseline.There were no clinically, or statistically, meaningful differences between arms, but there were modest reductions in body mass index, and positive, meaningful changes in diet and physical activity for both arms.The modest positive effects observed in this study may suggest that to achieve weight loss through the workplace more intensive interventions may be required.}, Doi = {10.1097/jom.0000000000000335}, Key = {fds272665} } @article{fds272662, Author = {Soubry, A and Murphy, SK and Wang, F and Huang, Z and Vidal, AC and Fuemmeler, BF and Kurtzberg, J and Murtha, A and Jirtle, RL and Schildkraut, JM and Hoyo, C}, Title = {Newborns of obese parents have altered DNA methylation patterns at imprinted genes}, Journal = {International Journal of Obesity (2005)}, Volume = {39}, Number = {4}, Pages = {650-657}, Year = {2015}, Month = {January}, ISSN = {0307-0565}, url = {http://dx.doi.org/10.1038/ijo.2013.193}, Abstract = {Background:Several epidemiologic studies have demonstrated associations between periconceptional environmental exposures and health status of the offspring in later life. Although these environmentally related effects have been attributed to epigenetic changes, such as DNA methylation shifts at imprinted genes, little is known about the potential effects of maternal and paternal preconceptional overnutrition or obesity.Objective:We examined parental preconceptional obesity in relation to DNA methylation profiles at multiple human imprinted genes important in normal growth and development, such as: maternally expressed gene 3 (MEG3), mesoderm-specific transcript (MEST), paternally expressed gene 3 (PEG3), pleiomorphic adenoma gene-like 1 (PLAGL1), epsilon sarcoglycan and paternally expressed gene 10 (SGCE/PEG10) and neuronatin (NNAT).Methods:We measured methylation percentages at the differentially methylated regions (DMRs) by bisulfite pyrosequencing in DNA extracted from umbilical cord blood leukocytes of 92 newborns. Preconceptional obesity, defined as BMI ≥30 kg m -2, was ascertained through standardized questionnaires.Results:After adjusting for potential confounders and cluster effects, paternal obesity was significantly associated with lower methylation levels at the MEST (β=-2.57; s.e.=0.95; P=0.008), PEG3 (β=-1.71; s.e.=0.61; P=0.005) and NNAT (β=-3.59; s.e.=1.76; P=0.04) DMRs. Changes related to maternal obesity detected at other loci were as follows: β-coefficient was +2.58 (s.e.=1.00; P=0.01) at the PLAGL1 DMR and -3.42 (s.e.=1.69; P=0.04) at the MEG3 DMR.Conclusion:We found altered methylation outcomes at multiple imprint regulatory regions in children born to obese parents, compared with children born to non-obese parents. In spite of the small sample size, our data suggest a preconceptional influence of parental life-style or overnutrition on the (re)programming of imprint marks during gametogenesis and early development. More specifically, the significant and independent association between paternal obesity and the offspring's methylation status suggests the susceptibility of the developing sperm for environmental insults. The acquired imprint instability may be carried onto the next generation and increase the risk for chronic diseases in adulthood.}, Doi = {10.1038/ijo.2013.193}, Key = {fds272662} } @article{fds272664, Author = {Lee, CT and Clark, TT and Kollins, SH and McClernon, JF and Fuemmeler, BF}, Title = {Attention Deficit Hyperactivity Disorder symptoms and smoking trajectories: Race and gender differences}, Journal = {Drug and Alcohol Dependence}, Volume = {148}, Pages = {180-187}, Year = {2015}, Month = {January}, ISSN = {0376-8716}, url = {http://dx.doi.org/10.1016/j.drugalcdep.2015.01.002}, Abstract = {© 2015 Elsevier Ireland Ltd. Purpose: This study examined the influence of Attention Deficit Hyperactivity Disorder (ADHD) symptoms severity and directionality (hyperactive-impulsive symptoms relative to inattentive symptoms) on trajectories of the probability of current (past month) smoking and the number of cigarettes smoked from age 13 to 32. Racial and gender differences in the relationship of ADHD symptoms and smoking trajectories were also assessed. Methods: A subsample of 9719 youth (54.5% female) was drawn from the National Longitudinal Study of Adolescent to Adult Health (Add Health). Cohort sequential design and zero-inflated Poisson (ZIP) latent growth modeling were used to estimate the relationship between ADHD directionality and severity on smoking development. Results: ADHD severity's effect on the likelihood of ever smoking cigarettes at the intercept (age 13) had a greater impact on White males than other groups. ADHD severity also had a stronger influence on the initial number of cigarettes smoked at age 13 among Hispanic participants. The relationships between ADHD directionality (hyperactive-impulsive symptoms relative to inattentive symptoms) and a higher number of cigarettes smoked at the intercept were stronger among Hispanic males than others. Gender differences manifested only among Whites. Conclusion: ADHD severity and directionality had unique effects on smoking trajectories. Our results also highlight that the risk of ADHD symptoms may differ by race and gender.}, Doi = {10.1016/j.drugalcdep.2015.01.002}, Key = {fds272664} } @article{fds272668, Author = {Lee, C-T and Stroo, M and Fuemmeler, B and Malhotra, R and Østbye, T}, Title = {Trajectories of depressive symptoms over 2 years postpartum among overweight or obese women.}, Journal = {Women'S Health Issues : Official Publication of the Jacobs Institute of Women'S Health}, Volume = {24}, Number = {5}, Pages = {559-566}, Year = {2014}, Month = {September}, ISSN = {1049-3867}, url = {http://dx.doi.org/10.1016/j.whi.2014.05.008}, Abstract = {Although depressive symptoms are common postpartum, few studies have followed women beyond 12 months postpartum to investigate changes in the number and severity of these symptoms over time, especially in overweight and obese women. Using two complementary analytical methods, this study aims to identify trajectories of depressive symptoms over 2 years postpartum among overweight or obese mothers, and assess the demographic, socioeconomic, and health covariates for these trajectories.Using longitudinal data from two behavioral intervention studies (Kids and Adults Now!-Defeat Obesity [KAN-DO] and Active Mothers Postpartum (AMP); n = 844), we used latent growth modeling to identify the overall trajectory of depressive symptoms and how it was related to key covariates. Next, we used latent class growth analysis to assess the heterogeneity in the depressive symptom trajectories over time, and thereby, identify subgroups of women with distinct trajectories.The overall trajectory of depressive symptoms over 2 years postpartum was relatively stable in our sample. However, the presence of three distinct latent class trajectories (stable-low [82.5%], decreasing symptoms [7.3%], and increasing symptoms [10.2%]), identified based on trajectory shape and mean depressive symptom score, supported heterogeneity in depressive symptom trajectories over time. Lower maternal education was related to a higher symptom score, and poorer subjective health status at baseline predicted inclusion in the increasing symptoms trajectory.In some overweight or obese mothers, postpartum depressive symptoms do not resolve quickly. Practitioners should be aware of this phenomenon and continue to screen for depression for longer periods of time postpartum.}, Doi = {10.1016/j.whi.2014.05.008}, Key = {fds272668} } @article{fds272669, Author = {Hoyo, C and Daltveit, AK and Iversen, E and Benjamin-Neelon, SE and Fuemmeler, B and Schildkraut, J and Murtha, AP and Overcash, F and Vidal, AC and Wang, F and Huang, Z and Kurtzberg, J and Seewaldt, V and Forman, M and Jirtle, RL and Murphy, SK}, Title = {Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort.}, Journal = {Epigenetics}, Volume = {9}, Number = {8}, Pages = {1120-1130}, Year = {2014}, Month = {August}, ISSN = {1559-2294}, url = {http://dx.doi.org/10.4161/epi.29332}, Abstract = {Epigenetic mechanisms are proposed to link maternal concentrations of methyl group donor nutrients with the risk of low birth weight. However, empirical data are lacking. We have examined the association between maternal folate and birth weight and assessed the mediating role of DNA methylation at nine differentially methylated regions (DMRs) of genomically imprinted genes in these associations. Compared with newborns of women with folate levels in the lowest quartile, birth weight was higher in newborns of mothers in the second (β = 143.2, se = 63.2, P = 0.02), third (β = 117.3, se = 64.0, P = 0.07), and fourth (β = 133.9, se = 65.2, P = 0.04) quartiles, consistent with a threshold effect. This pattern of association did not vary by race/ethnicity but was more apparent in newborns of non-obese women. DNA methylation at the PLAGL1, SGCE, DLK1/MEG3 and IGF2/H19 DMRs was associated with maternal folate levels and also birth weight, suggestive of threshold effects. MEG3 DMR methylation mediated the association between maternal folate levels and birth weight (P =0.06). While the small sample size and partial scope of examined DMRs limit our conclusions, our data suggest that, with respect to birth weight, no additional benefits may be derived from increased maternal folate concentrations, especially in non-obese women. These data also support epigenetic plasticity as a key mechanistic response to folate availability during early fetal development.}, Doi = {10.4161/epi.29332}, Key = {fds272669} } @article{fds272678, Author = {Hathcock, A and Krause, K and Viera, AJ and Fuemmeler, BF and Lovelady, C and Østbye, T}, Title = {Satiety responsiveness and the relationship between breastfeeding and weight status of toddlers of overweight and obese women.}, Journal = {Maternal and Child Health Journal}, Volume = {18}, Number = {4}, Pages = {1023-1030}, Year = {2014}, Month = {May}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23925718}, Abstract = {Numerous studies indicate an association between breastfeeding and decreased toddler adiposity. The mechanism behind this association is still unknown. One possibility is that children who are breastfed may have increased responsiveness to internal satiety cues. This study assessed the effect of satiety responsiveness on the association between breastfeeding and weight status among toddlers. We conducted a secondary analysis of data from 428 toddlers aged 2 years. Mothers' body mass index (BMI) and children's BMI z score were calculated from measured height and weight. Mothers completed a detailed breastfeeding survey and the satiety responsiveness subscale of the Child Eating Behaviour Questionnaire. Multiple linear regression and logistic regression were used to determine if satiety responsiveness mediated the effect of breastfeeding on BMI z score or overweight/obesity (BMI ≥ 85th percentile). Establishment of breastfeeding was associated with decreased BMI z score (0.40 vs. 0.60; p = 0.04), and increased breastfeeding intensity was associated with lower odds of overweight/obesity (OR 0.97, p = 0.04). Satiety responsiveness was not associated with either breastfeeding measures, suggesting it does not play a meditational role in the relationship between breastfeeding and toddler weight status. Furthermore, a relationship between satiety responsiveness and obesity does not exist after controlling for well-known confounders. This study did not find a mediation effect of satiety responsiveness on the association between breastfeeding and weight status in toddlers. More research is needed to characterize satiety responsiveness and its influence on the relationship between breastfeeding and childhood obesity.}, Doi = {10.1007/s10995-013-1331-9}, Key = {fds272678} } @article{fds272672, Author = {Thomas, DM and Weedermann, M and Fuemmeler, BF and Martin, CK and Dhurandhar, NV and Bredlau, C and Heymsfield, SB and Ravussin, E and Bouchard, C}, Title = {Dynamic model predicting overweight, obesity, and extreme obesity prevalence trends}, Journal = {Obesity (Silver Spring, Md.)}, Volume = {22}, Number = {2}, Pages = {590-597}, Year = {2014}, Month = {February}, ISSN = {1930-7381}, url = {http://dx.doi.org/10.1002/oby.20520}, Abstract = {Objective Obesity prevalence in the United States appears to be leveling, but the reasons behind the plateau remain unknown. Mechanistic insights can be provided from a mathematical model. The objective of this study is to model known multiple population parameters associated with changes in body mass index (BMI) classes and to establish conditions under which obesity prevalence will plateau. Design and Methods A differential equation system was developed that predicts population-wide obesity prevalence trends. The model considers both social and nonsocial influences on weight gain, incorporates other known parameters affecting obesity trends, and allows for country specific population growth. Results The dynamic model predicts that: obesity prevalence is a function of birthrate and the probability of being born in an obesogenic environment; obesity prevalence will plateau independent of current prevention strategies; and the US prevalence of overweight, obesity, and extreme obesity will plateau by about 2030 at 28%, 32%, and 9% respectively. Conclusions The US prevalence of obesity is stabilizing and will plateau, independent of current preventative strategies. This trend has important implications in accurately evaluating the impact of various anti-obesity strategies aimed at reducing obesity prevalence. © 2013 The Obesity Society.}, Doi = {10.1002/oby.20520}, Key = {fds272672} } @article{fds272683, Author = {Thomas, DM and Weedermann, M and Fuemmeler, BF and Martin, CK and Dhurandhar, NV and Bredlau, C and Heymsfield, SB and Ravussin, E and Bouchard, C}, Title = {Dynamic model predicting overweight, obesity, and extreme obesity prevalence trends.}, Journal = {Obesity (Silver Spring)}, Volume = {22}, Number = {2}, Pages = {590-597}, Year = {2014}, Month = {February}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23804487}, Abstract = {OBJECTIVE: Obesity prevalence in the United States appears to be leveling, but the reasons behind the plateau remain unknown. Mechanistic insights can be provided from a mathematical model. The objective of this study is to model known multiple population parameters associated with changes in body mass index (BMI) classes and to establish conditions under which obesity prevalence will plateau. DESIGN AND METHODS: A differential equation system was developed that predicts population-wide obesity prevalence trends. The model considers both social and nonsocial influences on weight gain, incorporates other known parameters affecting obesity trends, and allows for country specific population growth. RESULTS: The dynamic model predicts that: obesity prevalence is a function of birthrate and the probability of being born in an obesogenic environment; obesity prevalence will plateau independent of current prevention strategies; and the US prevalence of overweight, obesity, and extreme obesity will plateau by about 2030 at 28%, 32%, and 9% respectively. CONCLUSIONS: The US prevalence of obesity is stabilizing and will plateau, independent of current preventative strategies. This trend has important implications in accurately evaluating the impact of various anti-obesity strategies aimed at reducing obesity prevalence.}, Doi = {10.1002/oby.20520}, Key = {fds272683} } @article{fds272667, Author = {Vidal, AC and Benjamin Neelon and SE and Liu, Y and Tuli, AM and Fuemmeler, BF and Hoyo, C and Murtha, AP and Huang, Z and Schildkraut, J and Overcash, F and Kurtzberg, J and Jirtle, RL and Iversen, ES and Murphy, SK}, Title = {Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans.}, Journal = {Genetics & Epigenetics}, Volume = {6}, Pages = {37-44}, Year = {2014}, Month = {January}, url = {http://dx.doi.org/10.4137/GEG.S18067}, Abstract = {In infants exposed to maternal stress in utero, phenotypic plasticity through epigenetic events may mechanistically explain increased risk of preterm birth (PTB), which confers increased risk for neurodevelopmental disorders, cardiovascular disease, and cancers in adulthood. We examined associations between prenatal maternal stress and PTB, evaluating the role of DNA methylation at imprint regulatory regions. We enrolled women from prenatal clinics in Durham, NC. Stress was measured in 537 women at 12 weeks of gestation using the Perceived Stress Scale. DNA methylation at differentially methylated regions (DMRs) associated with H19, IGF2, MEG3, MEST, SGCE/PEG10, PEG3, NNAT, and PLAGL1 was measured from peripheral and cord blood using bisulfite pyrosequencing in a sub-sample of 79 mother-infant pairs. We examined associations between PTB and stress and evaluated differences in DNA methylation at each DMR by stress. Maternal stress was not associated with PTB (OR = 0.98; 95% CI, 0.40-2.40; P = 0.96), after adjustment for maternal body mass index (BMI), income, and raised blood pressure. However, elevated stress was associated with higher infant DNA methylation at the MEST DMR (2.8% difference, P < 0.01) after adjusting for PTB. Maternal stress may be associated with epigenetic changes at MEST, a gene relevant to maternal care and obesity. Reduced prenatal stress may support the epigenomic profile of a healthy infant.}, Doi = {10.4137/GEG.S18067}, Key = {fds272667} } @article{fds272671, Author = {Hathcock, A and Krause, K and Viera, AJ and Fuemmeler, BF and Lovelady, C and Østbye, T}, Title = {Satiety responsiveness and the relationship between breastfeeding and weight status of toddlers of overweight and obese women}, Journal = {Maternal and Child Health Journal}, Volume = {18}, Number = {4}, Pages = {1023-1030}, Year = {2014}, Month = {January}, ISSN = {1092-7875}, url = {http://dx.doi.org/10.1007/s10995-013-1331-9}, Abstract = {Numerous studies indicate an association between breastfeeding and decreased toddler adiposity. The mechanism behind this association is still unknown. One possibility is that children who are breastfed may have increased responsiveness to internal satiety cues. This study assessed the effect of satiety responsiveness on the association between breastfeeding and weight status among toddlers. We conducted a secondary analysis of data from 428 toddlers aged 2 years. Mothers' body mass index (BMI) and children's BMI z score were calculated from measured height and weight. Mothers completed a detailed breastfeeding survey and the satiety responsiveness subscale of the Child Eating Behaviour Questionnaire. Multiple linear regression and logistic regression were used to determine if satiety responsiveness mediated the effect of breastfeeding on BMI z score or overweight/obesity (BMI ≥ 85th percentile). Establishment of breastfeeding was associated with decreased BMI z score (0.40 vs. 0.60; p = 0.04), and increased breastfeeding intensity was associated with lower odds of overweight/obesity (OR 0.97, p = 0.04). Satiety responsiveness was not associated with either breastfeeding measures, suggesting it does not play a meditational role in the relationship between breastfeeding and toddler weight status. Furthermore, a relationship between satiety responsiveness and obesity does not exist after controlling for well-known confounders. This study did not find a mediation effect of satiety responsiveness on the association between breastfeeding and weight status in toddlers. More research is needed to characterize satiety responsiveness and its influence on the relationship between breastfeeding and childhood obesity. © 2013 Springer Science+Business Media New York.}, Doi = {10.1007/s10995-013-1331-9}, Key = {fds272671} } @article{fds272679, Author = {Lee, C-T and Fuemmeler, BF and McClernon, FJ and Ashley-Koch, A and Kollins, SH}, Title = {Nicotinic receptor gene variants interact with attention deficient hyperactive disorder symptoms to predict smoking trajectories from early adolescence to adulthood.}, Journal = {Addictive Behaviors}, Volume = {38}, Number = {11}, Pages = {2683-2689}, Year = {2013}, Month = {November}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23899432}, Abstract = {OBJECTIVE: To examine the association of single nucleotide polymorphisms (SNPs) of the CHRNB3 (rs13280604) and CHRNA6 (rs892413) nicotinic acetylcholine receptor (nAChR) genes and symptoms of attention deficit hyperactivity disorder (ADHD) in predicting smoking patterns from early adolescence to adulthood. METHOD: A longitudinal cohort of 1137 unrelated youths from the National Longitudinal Study of Adolescent Health provided responses to four surveys from Waves I to IV, and a genetic sample in Wave III. Growth mixture modeling was used to identify smoking patterns and to assess the effects of the two SNPs and ADHD symptoms on cigarette use over time. RESULTS: There were significant main effects of ADHD symptoms and CHRNA6 variants in predicting the number of cigarettes smoked and the pattern of use over time, respectively. There were no main effects of the CHRNB3 variants. However, a significant CHRNB3 variant×ADHD symptom interaction was observed, such that individuals with elevated ADHD symptoms and a particular CHRNB3 variant were at increased risk of cigarette use over time. CONCLUSIONS: These findings demonstrate that a SNP in a nicotinic receptor gene may interact with ADHD symptoms to link with increased cigarette use across adolescence and young adulthood. Unique associations between specific variants and patterns of ADHD symptoms were identified which may be useful for targeting prevention efforts to individuals at greatest risk for cigarette smoking.}, Doi = {10.1016/j.addbeh.2013.06.013}, Key = {fds272679} } @article{fds272680, Author = {Lee, C-T and McClernon, FJ and Kollins, SH and Prybol, K and Fuemmeler, BF}, Title = {Childhood economic strains in predicting substance use in emerging adulthood: mediation effects of youth self-control and parenting practices.}, Journal = {Journal of Pediatric Psychology}, Volume = {38}, Number = {10}, Pages = {1130-1143}, Year = {2013}, Month = {November}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23899658}, Abstract = {To examine the influence of childhood economic strains on substance use in young adulthood and to assess the mediating roles of self-control as well as positive parenting during adolescence in a nationally representative longitudinal cohort.The study included data from participants (n = 1,285) in the Panel Study of Income Dynamics, Child Development Supplement, and Transition to Adult. Structural equation modeling was used to evaluate the associations among risk factors during childhood and adolescence that predicted substance use in early adulthood.Conditions of economic strains, especially poverty, during childhood were associated with an increased likelihood of regular smoking in adulthood, which was partially mediated by poorer self-control during adolescence.Self-control is negatively affected by economic strains and serves as a mediator between poverty and risk of regular smoking. Additional research is needed to better understand how economic strains effect the development of self-control.}, Doi = {10.1093/jpepsy/jst056}, Key = {fds272680} } @article{fds272681, Author = {Østbye, T and Malhotra, R and Stroo, M and Lovelady, C and Brouwer, R and Zucker, N and Fuemmeler, B}, Title = {The effect of the home environment on physical activity and dietary intake in preschool children.}, Journal = {International Journal of Obesity (2005)}, Volume = {37}, Number = {10}, Pages = {1314-1321}, Year = {2013}, Month = {October}, ISSN = {0307-0565}, url = {http://hdl.handle.net/10161/11440 Duke open access}, Abstract = {The effects of the home environment on child health behaviors related to obesity are unclear.To examine the role of the home physical activity (PA) and food environment on corresponding outcomes in young children, and assess maternal education/work status as a moderator.Overweight or obese mothers reported on the home PA and food environment (accessibility, role modeling and parental policies). Outcomes included child moderate-vigorous PA (MVPA) and sedentary time derived from accelerometer data and two dietary factors ('junk' and healthy food intake scores) based on factor analysis of mother-reported food intake. Linear regression models assessed the net effect (controlling for child demographics, study arm, supplemental time point, maternal education/work status, child body mass index and accelerometer wear time (for PA outcomes)) of the home environment on the outcomes and moderation by maternal education/work status. Data were collected in North Carolina from 2007 to 2011.Parental policies supporting PA increased MVPA time, and limiting access to unhealthy foods increased the healthy food intake score. Role modeling of healthy eating behaviors increased the healthy food intake score among children of mothers with no college education. Among children of mothers with no college education and not working, limiting access to unhealthy foods and role modeling reduced 'junk' food intake scores whereas parental policies supporting family meals increased 'junk' food intake scores.To promote MVPA, parental policies supporting child PA are warranted. Limited access to unhealthy foods and role modeling of healthy eating may improve the quality of the child's food intake.}, Doi = {10.1038/ijo.2013.76}, Key = {fds272681} } @article{fds272682, Author = {Fuemmeler, B and Lee, C-T and Ranby, KW and Clark, T and McClernon, FJ and Yang, C and Kollins, SH}, Title = {Individual- and community-level correlates of cigarette-smoking trajectories from age 13 to 32 in a U.S. population-based sample.}, Journal = {Drug Alcohol Depend}, Volume = {132}, Number = {1-2}, Pages = {301-308}, Year = {2013}, Month = {September}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23499056}, Abstract = {BACKGROUND: Characterizing smoking behavior is important for informing etiologic models and targeting prevention efforts. This study explored the effects of both individual- and community-level variables in predicting cigarette use vs. non-use and level of use among adolescents as they transition into adulthood. METHODS: Data on 14,779 youths (53% female) were drawn from the National Longitudinal Study of Adolescent Health (Add Health); a nationally representative longitudinal cohort. A cohort sequential design allowed for examining trajectories of smoking typologies from age 13 to 32 years. Smoking trajectories were evaluated by using a zero-inflated Poisson (ZIP) latent growth analysis and latent class growth analysis modeling approach. RESULTS: Significant relationships emerged between both individual- and community-level variables and smoking outcomes. Maternal and peer smoking predicted increases in smoking over development and were associated with a greater likelihood of belonging to any of the four identified smoking groups versus Non-Users. Conduct problems and depressive symptoms during adolescence were related to cigarette use versus non-use. State-level prevalence of adolescent smoking was related to greater cigarette use during adolescence. CONCLUSIONS: Individual- and community-level variables that distinguish smoking patterns within the population aid in understanding cigarette use versus non-use and the quantity of cigarette use into adulthood. Our findings suggest that efforts to prevent cigarette use would benefit from attention to both parental and peer smoking and individual well-being. Future work is needed to better understand the role of variables in the context of multiple levels (individual and community-level) on smoking trajectories.}, Doi = {10.1016/j.drugalcdep.2013.02.021}, Key = {fds272682} } @article{fds272706, Author = {Fuemmeler, BF and Pendzich, MK and Clark, K and Lovelady, C and Rosoff, P and Blatt, J and Demark-Wahnefried, W}, Title = {Diet, physical activity, and body composition changes during the first year of treatment for childhood acute leukemia and lymphoma.}, Journal = {Journal of Pediatric Hematology/Oncology}, Volume = {35}, Number = {6}, Pages = {437-443}, Year = {2013}, Month = {August}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23211695}, Abstract = {Children who undergo treatment for childhood acute lymphoblastic leukemia (ALL) and lymphoma are at risk for several long-term health problems. Obesity, for which survivors of ALL and lymphoma are also at risk, may further exacerbate these problems. This pilot study evaluates changes in physical activity and body composition among children being treated for ALL and lymphoma and their parents.Recently diagnosed adolescent ALL and lymphoma patients were recruited from 2 pediatric hematology and oncology clinics, and matched on age, race, and sex to healthy individuals in the community. Changes in diet, physical activity, and body composition were collected at baseline, 6, and 12 months.All children (n=15) were, on average, 10.3 years of age at enrollment, and were fairly evenly distributed with regard to sex. Analyses revealed a significant difference between cases and controls with respect to the change in body mass index from baseline to 12 months (P=0.01). In addition, controls demonstrated a significantly greater increase in moderate-vigorous physical activity than the cases [229.8 metabolic equivalent of tasks (METs) vs. 23.5 METs]; indicating cases remained fairly inactive over the course of treatment.Our data corroborate previous findings that following treatment for ALL and lymphoma, childhood cancer survivors tend to be less active and at greater risk for obesity than their healthy peers. The present study, which assessed cases prospectively over a 12-month period during the early phases of treatment, extends prior reports by demonstrating that these outcomes are evident at an early stage in treatment.}, Doi = {10.1097/MPH.0b013e318279cd3e}, Key = {fds272706} } @article{fds272684, Author = {Vidal, AC and Murphy, SK and Murtha, AP and Schildkraut, JM and Soubry, A and Huang, Z and Neelon, SEB and Fuemmeler, B and Iversen, E and Wang, F and Kurtzberg, J and Jirtle, RL and Hoyo, C}, Title = {Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring.}, Journal = {International Journal of Obesity (2005)}, Volume = {37}, Number = {7}, Pages = {907-913}, Year = {2013}, Month = {July}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23609933}, Abstract = {Low birth weight (LBW) has been associated with common adult-onset chronic diseases, including obesity, cardiovascular disease, type II diabetes and some cancers. The etiology of LBW is multi-factorial. However, recent evidence suggests exposure to antibiotics may also increase the risk of LBW. The mechanisms underlying this association are unknown, although epigenetic mechanisms are hypothesized. In this study, we evaluated the association between maternal antibiotic use and LBW and examined the potential role of altered DNA methylation that controls growth regulatory imprinted genes in these associations.Between 2009-2011, 397 pregnant women were enrolled and followed until delivery. Prenatal antibiotic use was ascertained through maternal self-report. Imprinted genes methylation levels were measured at differentially methylated regions (DMRs) using bisulfite pyrosequencing. Generalized linear models were used to examine associations among antibiotic use, birth weight and DMR methylation fractions.After adjusting for infant gender, race/ethnicity, maternal body mass index, delivery route, gestational weight gain, gestational age at delivery, folic acid intake, physical activity, maternal smoking and parity, antibiotic use during pregnancy was associated with 138 g lower birth weight compared with non-antibiotic use (β-coefficient=-132.99, s.e.=50.70, P=0.008). These associations were strongest in newborns of women who reported antibiotic use other than penicillins (β-coefficient=-135.57, s.e.=57.38, P=0.02). Methylation at five DMRs, IGF2 (P=0.05), H19 (P=0.15), PLAGL1 (P=0.01), MEG3 (P=0.006) and PEG3 (P=0.08), was associated with maternal antibiotic use; among these, only methylation at the PLAGL1 DMR was also associated with birth weight.We report an inverse association between in utero exposure to antibiotics and lower infant birth weight and provide the first empirical evidence supporting imprinted gene plasticity in these associations.}, Doi = {10.1038/ijo.2013.47}, Key = {fds272684} } @article{fds272686, Author = {Østbye, T and Stroo, M and Brouwer, RJN and Peterson, BL and Eisenstein, EL and Fuemmeler, BF and Joyner, J and Gulley, L and Dement, JM}, Title = {The steps to health employee weight management randomized control trial: rationale, design and baseline characteristics.}, Journal = {Contemporary Clinical Trials}, Volume = {35}, Number = {2}, Pages = {68-76}, Year = {2013}, Month = {July}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23648394}, Abstract = {BACKGROUND: The workplace can be an important setting for addressing obesity. An increasing number of employers offer weight management programs. PURPOSE: Present the design, rationale and baseline characteristics of the Steps to Health study (STH), a randomized trial to evaluate the effectiveness of two preexisting employee weight management programs offered at Duke University and Medical Center. METHODS: 550 obese (BMI ≥30) employee volunteers were randomized 1:1 to two programs. Baseline data, collected between January 2011 and July 2012, included height/weight, accelerometry, workplace injuries, health care utilization, and questionnaires querying socio-cognitive factors, perceptions of health climate, physical activity, and dietary intake. In secondary analyses participants in the two programs will also be compared to a non-randomized observational control group of obese employees. RESULTS: At baseline, the mean age was 45 years, 83% were female, 41% white, and 53% black. Mean BMI was 37.2. Participants consumed a mean of 2.37 servings of fruits and vegetables per day (in the past week), participated in 11.5 min of moderate-to-vigorous physical activity, and spent 620 min being sedentary. CONCLUSION: STH addresses the need for evaluation of worksite interventions to promote healthy weight. In addition to having direct positive effects on workers' health, worksite programs have the potential to increase productivity and reduce health care costs.}, Doi = {10.1016/j.cct.2013.04.007}, Key = {fds272686} } @article{fds272685, Author = {Fuemmeler, BF and Lovelady, CA and Zucker, NL and Østbye, T}, Title = {Parental obesity moderates the relationship between childhood appetitive traits and weight.}, Journal = {Obesity (Silver Spring, Md.)}, Volume = {21}, Number = {4}, Pages = {815-823}, Year = {2013}, Month = {April}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23712985}, Abstract = {In this study, the independent and combined associations between childhood appetitive traits and parental obesity on weight gain from 0 to 24 months and body mass index (BMI) z-score at 24 months in a diverse community-based sample of dual parent families (n = 213) were examined.Participants were mothers who had recently completed a randomized trial of weight loss for overweight/obese postpartum women. As measures of childhood appetitive traits, mothers completed subscales of the Children's Eating Behavior Questionnaire, including Desire to Drink (DD), Enjoyment of Food (EF), and Satiety Responsiveness (SR), and a 24-h dietary recall for their child. Heights and weights were measured for all children and mothers and self-reported for mothers' partners. The relationship between children's appetitive traits and parental obesity on toddler weight gain and BMI z-score were evaluated using multivariate linear regression models, controlling for a number of potential confounders.Having two obese parents was related to greater weight gain from birth to 24 months independent of childhood appetitive traits, and although significant associations were found between appetitive traits (DD and SR) and child BMI z-score at 24 months, these associations were observed only among children who had two obese parents. When both parents were obese, increasing DD and decreasing SR were associated with a higher BMI z-score.The results highlight the importance of considering familial risk factors when examining the relationship between childhood appetitive traits on childhood obesity.}, Doi = {10.1002/oby.20144}, Key = {fds272685} } @article{fds272687, Author = {Corsino, L and McDuffie, JR and Kotch, J and Coeytaux, R and Fuemmeler, BF and Murphy, G and Miranda, ML and Poirier, B and Morton, J and Reese, D and Baker, S and Carter, H and Freeman, R and Blue, C and Yancy, WS}, Title = {Achieving health for a lifetime: a community engagement assessment focusing on school-age children to decrease obesity in Durham, North Carolina.}, Journal = {North Carolina Medical Journal}, Volume = {74}, Number = {1}, Pages = {18-26}, Year = {2013}, Month = {January}, ISSN = {0029-2559}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23530374}, Abstract = {BACKGROUND: Obesity is a prominent problem in the United States and in North Carolina. One way of combating it is with community-engaged interventions that foster collaboration between health-oriented organizations and community residents. PURPOSE: Our purpose was to assemble a multifaceted group in Durham, North Carolina, to identify factors affecting obesity-related lifestyle behaviors; assess policies, resources, and the population's perception of the problem of obesity; and develop plans to improve health outcomes related to obesity. METHODS: A team consisting of more than 2 dozen partners was assembled to form Achieving Health for a Lifetime (AHL) in order to study and address obesity in the community, initially focusing on elementary school-age children. The team developed a resource guide by collecting information by telephone interviews of provider organizations; geospatial resource maps were created using high-resolution geographic information systems, Duke's Data Support Repository, and county and city records; and focus groups were conducted using the nominal group technique. RESULTS: The AHL team, in collaboration with 2 other teams focused on diabetes and cardiovascular disease, identified 32 resources for diabetes, 20 for obesity, and 13 for cardiovascular disease. Using Geographic Information Systems (GIS), the team identified an area of Durham that had only 1 supermarket, but 34 fast-food restaurants and 84 convenience stores. LIMITATIONS: The focus on particular neighborhoods means that the information obtained might not pertain to all neighborhoods. CONCLUSION: The AHL team was able to assemble a large community partnership in Durham that will allow the members of the community to continue to work toward making residents healthier. Communities facing similar challenges can learn from this experience.}, Key = {fds272687} } @article{fds211229, Title = {Corsino, L., McDuffie, J.R., Kotch, J., Coeytaux, R., Fuemmeler, B.F., Murphy, G., Miranda, M.L., Poirier, B., Morton, J., Reese, D., Baker, S., Carter, H., Freeman, R., Blue, C., Yancy, W.S. (in press). Achieving health for a lifetime: a community engaged assessment to decrease obesity in Durham, North Carolina focusing on school-age children. North Carolina Medical Journal. }, Year = {2013}, Key = {fds211229} } @article{fds215515, Title = {Fuemmeler, B.F., Lovelady, C.A., Zucker, N.L., Ostbye, T. (in press). Parental obesity moderates relationship between childhood eating behaviors and weight. Obesity }, Year = {2013}, Key = {fds215515} } @article{fds272673, Author = {Østbye, T and Malhotra, R and Stroo, M and Lovelady, C and Brouwer, R and Zucker, N and Fuemmeler, B}, Title = {The effect of the home environment on physical activity and dietary intake in preschool children}, Journal = {International Journal of Obesity (2005)}, Volume = {37}, Number = {10}, Pages = {1314-1321}, Year = {2013}, ISSN = {0307-0565}, url = {http://dx.doi.org/10.1038/ijo.2013.76}, Abstract = {Background:The effects of the home environment on child health behaviors related to obesity are unclear.Purpose:To examine the role of the home physical activity (PA) and food environment on corresponding outcomes in young children, and assess maternal education/work status as a moderator.Methods:Overweight or obese mothers rePORted on the home PA and food environment (accessibility, role modeling and parental policies). Outcomes included child moderate-vigorous PA (MVPA) and sedentary time derived from accelerometer data and two dietary factors ('junk' and healthy food intake scores) based on factor analysis of mother-rePORted food intake. Linear regression models assessed the net effect (controlling for child demographics, study arm, supplemental time point, maternal education/work status, child body mass index and accelerometer wear time (for PA outcomes)) of the home environment on the outcomes and moderation by maternal education/work status. Data were collected in North Carolina from 2007 to 2011.Results:Parental policies supPORting PA increased MVPA time, and limiting access to unhealthy foods increased the healthy food intake score. Role modeling of healthy eating behaviors increased the healthy food intake score among children of mothers with no college education. Among children of mothers with no college education and not working, limiting access to unhealthy foods and role modeling reduced 'junk' food intake scores whereas parental policies supPORting family meals increased 'junk' food intake scores.Conclusions:To promote MVPA, parental policies supPORting child PA are warranted. Limited access to unhealthy foods and role modeling of healthy eating may improve the quality of the child's food intake. © 2013 Macmillan Publishers Limited.}, Doi = {10.1038/ijo.2013.76}, Key = {fds272673} } @article{fds272675, Author = {Fuemmeler, B and Lee, C-T and Ranby, KW and Clark, T and McClernon, FJ and Yang, C and Kollins, SH}, Title = {Individual- and community-level correlates of cigarette-smoking trajectories from age 13 to 32 in a U.S. population-based sample}, Journal = {Drug and Alcohol Dependence}, Volume = {132}, Number = {1-2}, Pages = {301-308}, Year = {2013}, ISSN = {0376-8716}, url = {http://dx.doi.org/10.1016/j.drugalcdep.2013.02.021}, Abstract = {Background: Characterizing smoking behavior is important for informing etiologic models and targeting prevention efforts. This study explored the effects of both individual- and community-level variables in predicting cigarette use vs. non-use and level of use among adolescents as they transition into adulthood. Methods: Data on 14,779 youths (53% female) were drawn from the National Longitudinal Study of Adolescent Health (Add Health); a nationally representative longitudinal cohort. A cohort sequential design allowed for examining trajectories of smoking typologies from age 13 to 32 years. Smoking trajectories were evaluated by using a zero-inflated Poisson (ZIP) latent growth analysis and latent class growth analysis modeling approach. Results: Significant relationships emerged between both individual- and community-level variables and smoking outcomes. Maternal and peer smoking predicted increases in smoking over development and were associated with a greater likelihood of belonging to any of the four identified smoking groups versus Non-Users. Conduct problems and depressive symptoms during adolescence were related to cigarette use versus non-use. State-level prevalence of adolescent smoking was related to greater cigarette use during adolescence. Conclusions: Individual- and community-level variables that distinguish smoking patterns within the population aid in understanding cigarette use versus non-use and the quantity of cigarette use into adulthood. Our findings suggest that efforts to prevent cigarette use would benefit from attention to both parental and peer smoking and individual well-being. Future work is needed to better understand the role of variables in the context of multiple levels (individual and community-level) on smoking trajectories. © 2013 Elsevier Ireland Ltd.}, Doi = {10.1016/j.drugalcdep.2013.02.021}, Key = {fds272675} } @article{fds272676, Author = {Fuemmeler, BF and Pendzich, MK and Clark, K and Lovelady, C and Rosoff, P and Blatt, J and Demark-Wahnefried, W}, Title = {Diet, physical activity, and body composition changes during the first year of treatment for childhood acute leukemia and lymphoma}, Journal = {Journal of Pediatric Hematology/Oncology}, Volume = {35}, Number = {6}, Pages = {437-443}, Year = {2013}, ISSN = {1077-4114}, url = {http://dx.doi.org/10.1097/MPH.0b013e318279cd3e}, Abstract = {Background: Children who undergo treatment for childhood acute lymphoblastic leukemia (ALL) and lymphoma are at risk for several long-term health problems. Obesity, for which survivors of ALL and lymphoma are also at risk, may further exacerbate these problems. This pilot study evaluates changes in physical activity and body composition among children being treated for ALL and lymphoma and their parents. Procedures: Recently diagnosed adolescent ALL and lymphoma patients were recruited from 2 pediatric hematology and oncology clinics, and matched on age, race, and sex to healthy individuals in the community. Changes in diet, physical activity, and body composition were collected at baseline, 6, and 12 months. Results: All children (n=15) were, on average, 10.3 years of age at enrollment, and were fairly evenly distributed with regard to sex. Analyses revealed a significant difference between cases and controls with respect to the change in body mass index from baseline to 12 months (P=0.01). In addition, controls demonstrated a significantly greater increase in moderate-vigorous physical activity than the cases [229.8 metabolic equivalent of tasks (METs) vs. 23.5 METs]; indicating cases remained fairly inactive over the course of treatment. Conclusions: Our data corroborate previous findings that following treatment for ALL and lymphoma, childhood cancer survivors tend to be less active and at greater risk for obesity than their healthy peers. The present study, which assessed cases prospectively over a 12-month period during the early phases of treatment, extends prior reports by demonstrating that these outcomes are evident at an early stage in treatment. © 2013 Lippincott Williams & Wilkins.}, Language = {ENG}, Doi = {10.1097/MPH.0b013e318279cd3e}, Key = {fds272676} } @article{fds272677, Author = {Vidal, AC and Murphy, SK and Murtha, AP and Schildkraut, JM and Soubry, A and Huang, Z and Neelon, SEB and Fuemmeler, B and Iversen, E and Wang, F and Kurtzberg, J and Jirtle, RL and Hoyo, C}, Title = {Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring}, Journal = {International Journal of Obesity (2005)}, Volume = {37}, Number = {7}, Pages = {907-913}, Year = {2013}, ISSN = {0307-0565}, url = {http://dx.doi.org/10.1038/ijo.2013.47}, Abstract = {Objectives: Low birth weight (LBW) has been associated with common adult-onset chronic diseases, including obesity, cardiovascular disease, type II diabetes and some cancers. The etiology of LBW is multi-factorial. However, recent evidence suggests exposure to antibiotics may also increase the risk of LBW. The mechanisms underlying this association are unknown, although epigenetic mechanisms are hypothesized. In this study, we evaluated the association between maternal antibiotic use and LBW and examined the potential role of altered DNA methylation that controls growth regulatory imprinted genes in these associations. Methods: Between 2009-2011, 397 pregnant women were enrolled and followed until delivery. Prenatal antibiotic use was ascertained through maternal self-report. Imprinted genes methylation levels were measured at differentially methylated regions (DMRs) using bisulfite pyrosequencing. Generalized linear models were used to examine associations among antibiotic use, birth weight and DMR methylation fractions. Results: After adjusting for infant gender, race/ethnicity, maternal body mass index, delivery route, gestational weight gain, gestational age at delivery, folic acid intake, physical activity, maternal smoking and parity, antibiotic use during pregnancy was associated with 138 g lower birth weight compared with non-antibiotic use (β-coefficient=-132.99, s.e.=50.70, P=0.008). These associations were strongest in newborns of women who reported antibiotic use other than penicillins (β-coefficient=-135.57, s.e.=57.38, P=0.02). Methylation at five DMRs, IGF2 (P=0.05), H19 (P=0.15), PLAGL1 (P=0.01), MEG3 (P=0.006) and PEG3 (P=0.08), was associated with maternal antibiotic use; among these, only methylation at the PLAGL1 DMR was also associated with birth weight. Conclusion: We report an inverse association between in utero exposure to antibiotics and lower infant birth weight and provide the first empirical evidence supporting imprinted gene plasticity in these associations. © 2013 Macmillan Publishers Limited.}, Doi = {10.1038/ijo.2013.47}, Key = {fds272677} } @article{fds272710, Author = {Liu, Y and Murphy, SK and Murtha, AP and Fuemmeler, BF and Schildkraut, J and Huang, Z and Overcash, F and Kurtzberg, J and Jirtle, R and Iversen, ES and Forman, MR and Hoyo, C}, Title = {Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements.}, Journal = {Epigenetics}, Volume = {7}, Number = {7}, Pages = {735-746}, Year = {2012}, Month = {July}, ISSN = {1559-2308}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22677950}, Keywords = {Adolescent • Adult • Birth Weight* • Cell Cycle Proteins • DNA Methylation* • Depression • Female • Genetic Loci • Genomic Imprinting* • High-Throughput Nucleotide Sequencing • Humans • Infant, Newborn • Insulin-Like Growth Factor II • Male • Pregnancy • Pregnancy Complications • RNA, Long Untranslated • RNA, Untranslated • Sequence Analysis, DNA • Transcription Factors • Tumor Suppressor Proteins • genetics • genetics*}, Abstract = {Depressed mood in pregnancy has been linked to low birth weight (LBW, < 2,500 g), a risk factor for adult-onset chronic diseases in offspring. We examined maternal depressed mood in relation to birth weight and evaluated the role of DNA methylation at regulatory sequences of imprinted genes in this association. We measured depressed mood among 922 pregnant women using the CES-D scale and obtained birth weight data from hospital records. Using bisulfite pyrosequencing of cord blood DNA from 508 infants, we measured methylation at differentially methylated regions (DMRs) regulating imprinted genes IGF2/H19, DLK1/MEG3, MEST, PEG3, PEG10/SGCE, NNAT and PLAGL1. Multiple regression models were used to examine the relationship between depressed mood, birth weight and DMR methylation levels. Depressed mood was associated with a more that 3-fold higher risk of LBW, after adjusting for delivery mode, parity, education, cigarette smoking, folic acid use and preterm birth. The association may be more pronounced in offspring of black women and female infants. Compared with infants of women without depressed mood, infants born to women with severe depressed mood had a 2.4% higher methylation at the MEG3 DMR. Whereas LBW infants had 1.6% lower methylation at the IGF2 DMR, high birth weight (> 4,500 g) infants had 5.9% higher methylation at the PLAGL1 DMR compared with normal birth weight infants. Our findings confirm that severe maternal depressed mood in pregnancy is associated with LBW, and that MEG3 and IGF2 plasticity may play important roles.}, Language = {eng}, Doi = {10.4161/epi.20734}, Key = {fds272710} } @article{fds272711, Author = {Fuemmeler, BF and Yang, C and Costanzo, P and Hoyle, RH and Siegler, IC and Williams, RB and Ostbye, T}, Title = {Parenting styles and body mass index trajectories from adolescence to adulthood.}, Journal = {Health Psychology}, Volume = {31}, Number = {4}, Pages = {441-449}, Year = {2012}, Month = {July}, ISSN = {1930-7810}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22545979}, Keywords = {Adolescent • Adolescent Development* • African Americans • Authoritarianism • Automobile Driving • Body Mass Index* • Female • Hispanic Americans • Humans • Longitudinal Studies • Male • Obesity • Parenting • Parents • Permissiveness • Young Adult • epidemiology* • ethnology • psychology • psychology*}, Abstract = {OBJECTIVE: Parenting styles such as authoritarian, disengaged, or permissive are thought to be associated with greater adolescent obesity risk than an authoritative style. This study assessed the relationship between parenting styles and changes in body mass index (BMI) from adolescence to young adulthood. METHOD: The study included self-reported data from adolescents in the National Longitudinal Study of Adolescent Health. Factor mixture modeling, a data-driven approach, was used to classify participants into parenting style groups based on measures of acceptance and control. Latent growth modeling (LGM) identified patterns of developmental changes in BMI. After a number of potential confounders were controlled for, parenting style variables were entered as predictors of BMI trajectories. Analyses were also conducted for male and female individuals of 3 racial-ethnic groups (Hispanic, black, white) to assess whether parenting styles were differentially associated with BMI trajectories in these 6 groups. RESULTS: Parenting styles were classified into 4 groups: authoritarian, disengaged, permissive, and balanced. Compared with the balanced parenting style, authoritarian and disengaged parenting styles were associated with a less steep average BMI increase (linear slope) over time, but also less leveling off (quadratic) of BMI over time. Differences in BMI trajectories were observed for various genders and races, but the differences did not reach statistical significance. CONCLUSION: Adolescents who reported having parents with authoritarian or disengaged parenting styles had greater increases in BMI as they transitioned to young adulthood despite having a lower BMI trajectory through adolescence.}, Language = {eng}, Doi = {10.1037/a0027927}, Key = {fds272711} } @article{fds272707, Author = {Van Voorhees and E and McClernon, FJ and Fuemmeler, B and English, J and Holdaway, A and Hallyburton, M and Dew, R and Kollins, S}, Title = {An examination of differences in variables maintaining smoking behavior in adult smokers with and without attention-deficit/hyperactivity disorder}, Journal = {Addiction Research & Theory}, Volume = {20}, Number = {1}, Pages = {72-81}, Publisher = {Informa UK Limited}, Year = {2012}, Month = {February}, ISSN = {1606-6359}, url = {http://dx.doi.org/10.3109/16066359.2011.564692}, Abstract = {Individuals with attention-deficit/hyperactivity disorder (ADHD) smoke cigarettes at higher rates and have greater difficulty quitting than their non-diagnosed peers. This study examined differences between smokers with and without ADHD on a range of smoking-related variables. Twenty-two subjects with ADHD and 22 controls completed self-report measures of withdrawal symptoms, smoking motivation, sensory experience of smoking, and positive and negative affect. Compared to control smokers, smokers with ADHD reported greater craving and negative affect; perceived smoking as providing greater enhancement of concentration and alertness, as more calming, and as providing a greater decrease in irritability; found cigarette puffs to be more enjoyable and satisfying; and rated smoking as providing greater positive and negative reinforcement and greater cognitive enhancement. Women with ADHD reported the greatest effects of smoking on improving concentration and reducing irritability. Findings support the hypothesis that smokers with ADHD may experience smoking differently than smokers without the disorder, and that they may identify different motivations for smoking.}, Doi = {10.3109/16066359.2011.564692}, Key = {fds272707} } @article{fds272712, Author = {Bidwell, LC and Garrett, ME and McClernon, FJ and Fuemmeler, BF and Williams, RB and Ashley-Koch, AE and Kollins, SH}, Title = {A preliminary analysis of interactions between genotype, retrospective ADHD symptoms, and initial reactions to smoking in a sample of young adults.}, Journal = {Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco}, Volume = {14}, Number = {2}, Pages = {229-233}, Year = {2012}, Month = {February}, ISSN = {1469-994X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/21778150}, Keywords = {Aryl Hydrocarbon Hydroxylases • Attention Deficit Disorder with Hyperactivity • Exploratory Behavior • Female • Genetic Predisposition to Disease • Genotype* • Humans • Linear Models • Longitudinal Studies • Male • Monoamine Oxidase • Polymorphism, Genetic • Receptors, Dopamine D2 • Receptors, Dopamine D4 • Retrospective Studies • Risk Factors • Self Report • Serotonin Plasma Membrane Transport Proteins • Smoking • Synaptic Transmission • Young Adult • epidemiology • genetics • genetics* • pathology*}, Abstract = {Initial reactions to cigarettes predict later regular smoking. Symptoms of attention deficit hyperactivity disorder (ADHD) have also been shown to increase smoking risk and may moderate the relationship between genotype and smoking. We conducted an exploratory study to assess whether ADHD symptoms interact with genetic variation to predict self-reported initial reactions to smoking.Participants were a subsample of 1,900 unrelated individuals with genotype data drawn from the National Longitudinal Study of Adolescent Health (Add Health), a nationally representative sample of adolescents followed from 1995 to 2002. Linear regression was used to examine relationships among self-reported ADHD symptoms, genotype, and self-reported initial reactions to cigarettes (index scores reflecting pleasant and unpleasant reactions).Polymorphisms in the DRD2 gene, SLC6A4 gene, and among males, the MAOA gene interacted with retrospective reports of ADHD symptoms in predicting pleasant initial reaction to cigarettes. Polymorphisms in the CYP2A6 gene and, among females, the MAOA gene interacted with retrospective reports of ADHD symptoms in predicting unpleasant initial reaction to cigarettes. No main effect for any of these polymorphisms was observed nor were any interactions with DRD4 and DAT genes.These findings suggest that genotypes associated with monoamine neurotransmission interact with ADHD symptoms to influence initial reactions to cigarette smoking. Given that an initial pleasant reaction to cigarettes increases risk for lifetime smoking, these results add to a growing body of literature that suggests that ADHD symptoms increase risk for smoking and should be accounted for in genetic studies of smoking.}, Language = {eng}, Doi = {10.1093/ntr/ntr125}, Key = {fds272712} } @article{fds272708, Author = {Ranby, KW and Boynton, MH and Kollins, SH and McClernon, FJ and Yang, C and Fuemmeler, BF}, Title = {Understanding the phenotypic structure of adult retrospective ADHD symptoms during childhood in the United States.}, Journal = {Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53}, Volume = {41}, Number = {3}, Pages = {261-274}, Year = {2012}, Month = {January}, ISSN = {1537-4424}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22394329}, Keywords = {Adolescent • Adult • Attention Deficit Disorder with Hyperactivity • Child • Child, Preschool • Female • Humans • Interviews as Topic • Longitudinal Studies • Male • Phenotype • Retrospective Studies • Severity of Illness Index • United States • diagnosis* • psychology}, Abstract = {Attention-deficit/hyperactivity disorder (ADHD) is a highly heterogeneous disorder, and the phenotypic structure comprising inattentive and hyperactive-impulsive type symptoms has been the focus of a growing body of recent research. Methodological studies are needed to better characterize phenotypes to advance research as well as clinical practice. A large U.S. population-based sample of young adults (N = 14,307, aged 17-28 years, 52.8% female) retrospectively reported their experiences of childhood ADHD symptoms. Factor analysis, latent class analysis, and factor mixture modeling of ADHD symptoms were compared to determine which underlying structure best fit the data. Fit statistics as well as substantive criteria compared models within and across model subtypes. Analyses supported a two-factor two-class structure for both male and female subjects. The two latent factors represented inattentive and hyperactive-impulsive symptom dimensions. The two latent classes divided people into a smaller affected class and a larger unaffected class. Individuals who reported having been diagnosed with ADHD were more likely to be in the affected class (OR male subjects = 4.03, 95% CI [2.65, 6.13]; OR female subjects = 5.65, 95% CI [3.15, 10.10]). This work aids in the understanding of ADHD symptomatology within the population; a majority of people experience very low symptom severity, whereas a minority of people experience high symptom severity. Within this high symptom group, however, variability in symptom experiences exists. Empirical models can be helpful in clarifying ADHD phenotypic structure that has the potential to advance research on the etiology and consequences of ADHD symptoms.}, Language = {eng}, Doi = {10.1080/15374416.2012.654465}, Key = {fds272708} } @article{fds188032, Title = {Van Voorhees, E.E., McClernon, F.J., Fuemmeler, B.F., English, J., Holdaway, A., Hallyburton, M. Dew, R., Kollins, S. H. (2012). An examination of differences in variable maintaining smoking behavior in adult smokers with and without Attention-Deficit/Hyperactivity Disorder (ADHD). Addiction Research and Theory, Vol 20 (1). 72-81. }, Year = {2012}, Key = {fds188032} } @article{fds272705, Author = {Breton, ER and Fuemmeler, BF and Abroms, LC}, Title = {Weight loss-there is an app for that! But does it adhere to evidence-informed practices?}, Journal = {Translational Behavioral Medicine}, Volume = {1}, Number = {4}, Pages = {523-529}, Year = {2011}, Month = {December}, ISSN = {1869-6716}, url = {http://dx.doi.org/10.1007/s13142-011-0076-5}, Abstract = {Little is known about how much smartphone apps for weight control adhere to evidence-informed practices. The aim of this study was to review and summarize the content of available weight control apps. Information on content, user rating, and price was extracted from iTunes on September 25, 2009. Apps (n = 204) were coded for adherence to 13 evidence-informed practices for weight control. Latent class analysis was used to identify subgroups of apps based on endorsement practices. Only a small percentage of apps had five or more of the 13 practices (15%). Latent class analysis revealed three main types of apps: diet, physical activity, and weight journals (19%); dietary advice and journals (34%); and weight trackers (46%). User ratings were not associated with apps from these three classes. Many apps have insufficient evidence-informed content. Research is needed that seeks to develop, improve, and evaluate these apps.}, Doi = {10.1007/s13142-011-0076-5}, Key = {fds272705} } @article{fds272704, Author = {Chang, S and Mâsse, LC and Moser, RP and Dodd, KW and Arganaraz, F and Fuemmeler, BF and Jemal, A}, Title = {Erratum: State ranks of incident cancer burden due to overweight and obesity in the United States, 2003 (Obesity 16 (1636-1650) DOI: 10.1038/oby.2008.228)}, Journal = {Obesity (Silver Spring, Md.)}, Volume = {19}, Number = {11}, Pages = {2288-2290}, Publisher = {WILEY}, Year = {2011}, Month = {November}, ISSN = {1930-7381}, url = {http://dx.doi.org/10.1038/oby.2011.112}, Doi = {10.1038/oby.2011.112}, Key = {fds272704} } @article{fds272713, Author = {Agurs-Collins, T and Fuemmeler, BF}, Title = {Dopamine polymorphisms and depressive symptoms predict foods intake. Results from a nationally representative sample.}, Journal = {Appetite}, Volume = {57}, Number = {2}, Pages = {339-348}, Year = {2011}, Month = {October}, ISSN = {1095-8304}, url = {http://www.ncbi.nlm.nih.gov/pubmed/21672565}, Keywords = {Adolescent • Adult • Alleles • Depression • Dopamine Plasma Membrane Transport Proteins • Energy Intake • Female • Food Preferences* • Genetic Predisposition to Disease • Genotype • Humans • Linear Models • Longitudinal Studies • Male • Monoamine Oxidase • Multivariate Analysis • Polymorphism, Genetic* • Receptors, Dopamine D2 • Receptors, Dopamine D4 • Young Adult • genetics • genetics* • metabolism}, Abstract = {Depression and variation in dopamine related genes have both independently been associated with food consumption. Depressive symptoms could synergistically interact with genetic variation to influence food intake. We examined the interaction between high depressive symptoms and functional polymorphisms of dopamine transporter (SLC6A3), monoamine oxidase A (MAOA), dopamine receptor D2 (DRD2) and dopamine receptor D4 (DRD4) on intake of high-calorie sweet, high-calorie non-sweet, and low-calorie foods in the National Longitudinal Study of Adolescent Health (Add Health). Multivariate linear regression analyses were used to examine main effects of gene and depression symptoms and their interaction (genotype-by-high depression symptoms) on food categories. Applying a false discovery rate criterion for multiple comparisons indicated a statistically significant interaction for females with high depressive symptoms and the SLC6A3 gene, such that those with the SLC6A3 10/10 allele reported greater intake of high-calorie sweet foods than their counterparts high in depressive symptoms with the SLC6A3 any 9 allele (LS mean 10/10 allele=2.5, SE=.13; LS mean any 9 allele=1.8, SE=.13, p<.05). These findings highlight that the relationship between depression and food intake may vary as a function of genetic polymorphism. Further research is needed to confirm these findings.}, Language = {eng}, Doi = {10.1016/j.appet.2011.05.325}, Key = {fds272713} } @article{fds272716, Author = {Fuemmeler, BF and Østbye, T and Yang, C and McClernon, FJ and Kollins, SH}, Title = {Association between attention-deficit/hyperactivity disorder symptoms and obesity and hypertension in early adulthood: a population-based study.}, Journal = {International Journal of Obesity (2005)}, Volume = {35}, Number = {6}, Pages = {852-862}, Year = {2011}, Month = {June}, ISSN = {1476-5497}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20975727}, Keywords = {Adolescent • Adult • Age Factors • Attention Deficit Disorder with Hyperactivity • Body Mass Index • Female • Humans • Hypertension • Longitudinal Studies • Male • Obesity • Odds Ratio • Prevalence • Risk Factors • United States • Young Adult • complications* • epidemiology • etiology*}, Abstract = {To examine the associations between attention-deficit/hyperactivity disorder (ADHD) symptoms, obesity and hypertension in young adults in a large population-based cohort.The study population consisted of 15,197 respondents from the National Longitudinal Study of Adolescent Health, a nationally representative sample of adolescents followed from 1995 to 2009 in the United States. Multinomial logistic and logistic models examined the odds of overweight, obesity and hypertension in adulthood in relation to retrospectively reported ADHD symptoms. Latent curve modeling was used to assess the association between symptoms and naturally occurring changes in body mass index (BMI) from adolescence to adulthood.Linear association was identified between the number of inattentive (IN) and hyperactive/impulsive (HI) symptoms and waist circumference, BMI, diastolic blood pressure and systolic blood pressure (all P-values for trend <0.05). Controlling for demographic variables, physical activity, alcohol use, smoking and depressive symptoms, those with three or more HI or IN symptoms had the highest odds of obesity (HI 3+, odds ratio (OR)=1.50, 95% confidence interval (CI) = 1.22-2.83; IN 3+, OR = 1.21, 95% CI = 1.02-1.44) compared with those with no HI or IN symptoms. HI symptoms at the 3+ level were significantly associated with a higher OR of hypertension (HI 3+, OR = 1.24, 95% CI = 1.01-1.51; HI continuous, OR = 1.04, 95% CI = 1.00-1.09), but associations were nonsignificant when models were adjusted for BMI. Latent growth modeling results indicated that compared with those reporting no HI or IN symptoms, those reporting 3 or more symptoms had higher initial levels of BMI during adolescence. Only HI symptoms were associated with change in BMI.Self-reported ADHD symptoms were associated with adult BMI and change in BMI from adolescence to adulthood, providing further evidence of a link between ADHD symptoms and obesity.}, Language = {eng}, Doi = {10.1038/ijo.2010.214}, Key = {fds272716} } @article{fds272714, Author = {Fuemmeler, BF and Anderson, CB and Mâsse, LC}, Title = {Parent-child relationship of directly measured physical activity.}, Journal = {The International Journal of Behavioral Nutrition and Physical Activity}, Volume = {8}, Pages = {17}, Year = {2011}, Month = {March}, ISSN = {1479-5868}, url = {http://www.ncbi.nlm.nih.gov/pubmed/21385455}, Keywords = {Actigraphy • Adult • Child • Child Behavior* • Exercise* • Female • Health Behavior* • Humans • Male • Middle Aged • Monitoring, Ambulatory • Parents* • Physical Exertion • Regression Analysis • Sedentary Lifestyle* • methods}, Abstract = {Studies on parent-child correlations of physical activity have been mixed. Few studies have examined concurrent temporal patterns of physical activity and sedentary behaviors in parents and children using direct measures. The purpose of this study was to examine parent-child activity correlations by gender, day of week, and time of day, using accelerometers - a method for direct assessment of physical activity.Accelerometers were used to assess physical activity and sedentary time in 45 fathers, 45 mothers and their children (23 boys, 22 girls, mean age 9.9 years) over the course of 4 days (Thursday - Sunday). Participants were instructed to wear accelerometers for 24 hours per day. Data from accelerometers were aggregated into waking hours on weekdays and weekends (6:00 am to midnight) and weekday after-school hours (3:00 - 7:00 pm).Across the 4 days, the mean minutes per day of moderate-to-vigorous physical activity (MVPA) for fathers was 30.0 (s.d. = 17.3), for mothers was 30.1 (s.d. = 20.1) and for children was 145.47 (s.d. = 51.64). Mothers' and fathers' minutes of MVPA and minutes of sedentary time were positively correlated with child physical activity and sedentary time (all ps < .05, with the exception of mothers' and children's sedentary time on weekdays from 6 am to 12 am). Multivariate linear regression analyses resulted in significant effects between parents and children for MVPA across all time segments. For sedentary activity, significant associations were observed only between father and child on the weekend. Sedentary activity of parents and children were not related for other time segments. Models examining the associations of one or two parents with high levels of MVPA or sedentary time indicated a dose response increase in child activity relative to parent.Greater parental MVPA was associated with increased child MVPA. In addition, having two parents with higher levels of MVPA was associated with greater levels of activity in children. Sedentary time in children was not as strongly correlated with that of their parents. Findings lend support to the notion that to increase childhood activity levels it may be fruitful to improve physical activity among parents.}, Language = {eng}, Doi = {10.1186/1479-5868-8-17}, Key = {fds272714} } @article{fds188033, Title = {Fuemmeler, B.F., Anderson, C.B., Masse, L. (in press). Parent-child relationship of directly measured physical activity. International Journal of Behavioral Nutrition and Physical Activity.}, Year = {2011}, Key = {fds188033} } @article{fds191939, Title = {Bidwell, L.C., Garret, M.E., McClernon, F.J., Fuemmeler, B.F., Williams, R.B., Ashley-Koch, A.E., Kollins, S.H. (in press). A preliminary analysis of interactions between genotype, retrospective ADHD symptoms, and initial reactions to smoking in a sample of young adults. Nicotine & Tobacco Research }, Year = {2011}, Key = {fds191939} } @article{fds191940, Title = {Agurs-Collins, T., Fuemmeler, B.F. (in press). Dopamine polymorphismis and depressive symptoms predict food intake: results from a nationally representative sample. Appetite. }, Year = {2011}, Key = {fds191940} } @article{fds202521, Title = {35. Brenton E.R, Fuemmeler, B.F., Abroms, L. (2011). Weight loss – there’s an app for that! But does it adhere to evidence-informed practices? Translational Behavior Medicine, 1(4): 523-529.}, Year = {2011}, Key = {fds202521} } @article{fds211228, Title = {Breton E.R, Fuemmeler, B.F., Abroms, L. (2011). Weight loss – there’s an app for that! But does it adhere to evidence-informed practices? Translational Behavior Medicine, 1(4): 523-529.}, Year = {2011}, Key = {fds211228} } @article{fds272715, Author = {Dedert, EA and Becker, ME and Fuemmeler, BF and Braxton, LE and Calhoun, PS and Beckham, JC}, Title = {Childhood traumatic stress and obesity in women: the intervening effects of PTSD and MDD.}, Journal = {Journal of Traumatic Stress}, Volume = {23}, Number = {6}, Pages = {785-763}, Year = {2010}, Month = {December}, ISSN = {1573-6598}, url = {http://www.ncbi.nlm.nih.gov/pubmed/21171140}, Keywords = {Adult • Depressive Disorder, Major • Female • Humans • Middle Aged • Obesity • Questionnaires • Stress Disorders, Post-Traumatic • United States • Wounds and Injuries • complications* • diagnosis • epidemiology • etiology • psychology*}, Abstract = {In this study, symptoms of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) were modeled as intervening variables in the relationship between childhood traumatic stress and weight outcomes in civilian women in the United States. Of the 148 participants, 72 had current PTSD, 64 had current MDD, and 32 had neither disorder. In separate single indirect effect models, there were significant indirect effects of both PTSD and depressive symptoms on body mass index and waist-hip ratio. When models included both PTSD and depressive symptoms, an indirect effect of PTSD symptoms was evident in the relationship between childhood traumatic stress and waist-hip ratio. Posttraumatic stress disorder may play a particularly important role in the development of central adiposity.}, Language = {eng}, Doi = {10.1002/jts.20584}, Key = {fds272715} } @article{fds272691, Author = {Boynton, MH and Fuemmeler, BF}, Title = {HUMAN HEALTH AND THE NESTED NATURE OF THE VARIABLES WE USE TO UNDERSTAND IT: THE UTILITY OF THE SIMULTANEOUS IMPLEMENTATION OF MULTIPLE LEVELS OF ANALYSIS IN THE MODELING OF HEALTH BEHAVIOR}, Journal = {Annals of Behavioral Medicine}, Volume = {39}, Pages = {112-112}, Year = {2010}, Month = {April}, ISSN = {0883-6612}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000275841700434&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds272691} } @article{fds180615, Title = {Fuemmeler, B.F., Ostbye, T.O, Yang, C., McClernon, F.J., and Kollins, S.H. (in press). Association between Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms and obesity and hypertension in early adulthood: A population-based study. International Journal of Obesity.}, Year = {2010}, Key = {fds180615} } @article{fds180616, Title = {Dedert, E.A., Becker, M.E., Fuemmeler, B.F., Braxton, L.E., Calhoun, P.S., and Beckham, J.C. (in press). The roles of posttraumatic stress disorder and major depressive disorder in childhood traumatic stress and weight problems among women. Journal of Traumatic Stress}, Year = {2010}, Key = {fds180616} } @article{fds272718, Author = {Fuemmeler, BF and Dedert, E and McClernon, FJ and Beckham, JC}, Title = {Adverse childhood events are associated with obesity and disordered eating: results from a U.S. population-based survey of young adults.}, Journal = {Journal of Traumatic Stress}, Volume = {22}, Number = {4}, Pages = {329-333}, Year = {2009}, Month = {August}, ISSN = {1573-6598}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19588510}, Keywords = {Adolescent • Child • Child Abuse • Cross-Sectional Studies • Eating Disorders • Female • Health Surveys • Humans • Male • Obesity • Odds Ratio • Risk Factors • United States • Young Adult • epidemiology • epidemiology* • psychology • psychology*}, Abstract = {The authors investigated the relationship between childhood abuse and obesity in young adulthood (M age = 22) in a large, U.S. representative sample (N = 15,197). Controlling for demographics and depression, men with a history of childhood sexual abuse were at increased risk of overweight and obesity. No association between childhood abuse and obesity or overweight was observed for women in this sample. Higher percentages of skipping meals to lose weight and problematic eating were observed among women with a history of physical abuse. This is the first study to note an association between childhood abuse with obesity and problematic weight management behaviors in a sample of young adults.}, Language = {eng}, Doi = {10.1002/jts.20421}, Key = {fds272718} } @article{fds272719, Author = {Anderson, CB and Hughes, SO and Fuemmeler, BF}, Title = {Parent-child attitude congruence on type and intensity of physical activity: testing multiple mediators of sedentary behavior in older children.}, Journal = {Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association}, Volume = {28}, Number = {4}, Pages = {428-438}, Year = {2009}, Month = {July}, ISSN = {0278-6133}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19594267}, Keywords = {Adult • Attitude* • Computers • Culture • Exercise • Female • Humans • Life Style* • Male • Middle Aged • Motor Activity* • Parent-Child Relations* • Parenting • Socialization • Sports • Statistics as Topic • Television • psychology • psychology*}, Abstract = {This study examined parent-child attitudes on value of specific types and intensities of physical activity, which may explain gender differences in child activity, and evaluated physical activity as a mechanism to reduce time spent in sedentary behaviors.A community sample of 681 parents and 433 children (mean age 9.9 years) reported attitudes on importance of vigorous and moderate intensity team and individually performed sports/activities, as well as household chores. Separate structural models (LISREL 8.7) for girls and boys tested whether parental attitudes were related to child TV and computer via child attitudes, sport team participation, and physical activity, controlling for demographic factors.Child 7-day physical activity, sport teams, weekly TV, computer.Parent-child attitude congruence was more prevalent among boys, and attitudes varied by ethnicity, parent education, and number of children. Positive parent-child attitudes for vigorous team sports were related to increased team participation and physical activity, as well as reduced TV and computer in boys and girls. Value of moderate intensity household chores, such as cleaning house and doing laundry, was related to decreased team participation and increased TV in boys. Only organized team sports, not general physical activity, was related to reduced TV and computer.Results support parents' role in socializing children's achievement task values, affecting child activity by transferring specific attitudes. Value of vigorous intensity sports provided the most benefits to activity and reduction of sedentary behavior, while valuing household chores had unexpected negative effects.}, Language = {eng}, Doi = {10.1037/a0014522}, Key = {fds272719} } @article{fds272720, Author = {Fuemmeler, BF and Agurs-Collins, T and McClernon, FJ and Kollins, SH and Garrett, ME and Ashley-Koch, AE}, Title = {Interactions between genotype and depressive symptoms on obesity.}, Journal = {Behavior Genetics}, Volume = {39}, Number = {3}, Pages = {296-305}, Year = {2009}, Month = {May}, ISSN = {1573-3297}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19337825}, Keywords = {Adolescent • Alleles • Body Mass Index* • Confidence Intervals • Depression • Depressive Disorder • Female • Genetic Predisposition to Disease • Genotype* • Humans • Longitudinal Studies • Male • Monoamine Oxidase • Obesity • Odds Ratio • Overweight • Personality Inventory • Phenotype • Polymorphism, Genetic • Psychometrics • Risk Factors • Serotonin Plasma Membrane Transport Proteins • Sex Factors • Young Adult • genetics • genetics* • psychology • statistics & numerical data}, Abstract = {Depression and Genetic variation in serotonin and monoamine transmission have both been associated with body mass index (BMI), but their interaction effects are not well understood. We examined the interaction between depressive symptoms and functional polymorphisms of serotonin transporter (SLC6A4) and monoamine oxidase A (MAOA) on categories of BMI. Participants were from the National Longitudinal Study of Adolescent Health. Multiple logistic regression was used to investigate interactions between candidate genes and depression on risk of obesity (BMI > or = 30) or overweight + obese combined (BMI > or = 25). Males with an MAOA active allele with high depressive symptoms were at decreased risk of obesity (OR 0.22; 95% CI 0.06-0.78) and overweight + obesity (OR 0.48; 95% CI 0.26-0.89). No similar effect was observed among females. These findings highlight that the obesity-depression relationship may vary as a function of gender and genetic polymorphism, and suggest the need for further study.}, Language = {eng}, Doi = {10.1007/s10519-009-9266-z}, Key = {fds272720} } @article{fds272717, Author = {Fuemmeler, BF and Pendzich, MK and Tercyak, KP}, Title = {Weight, dietary behavior, and physical activity in childhood and adolescence: implications for adult cancer risk.}, Journal = {Obesity Facts}, Volume = {2}, Number = {3}, Pages = {179-186}, Year = {2009}, Month = {January}, ISSN = {1662-4025}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20054223}, Keywords = {Adolescent • Adult • Body Weight • Child • Food Habits* • Humans • Motor Activity* • Neoplasms • Obesity • Risk Factors • epidemiology*}, Abstract = {Lifestyle factors related to energy balance, including weight, dietary behavior and physical activity, are associated with cancer risk. The period of childhood and growth into adolescence and early adulthood may re-present a 'cumulative risk' for later adult-onset cancers. We review a number of epidemiologic studies that have examined associations among childhood and adolescent body size, diet, and physical activity with adult cancer risk. These studies suggest that unhealthy behaviors that develop early in life and persist over time may increase the risk of some cancer types, such as premenopausal breast, ovarian, endometrial, colon and renal cancer, adversely affect cancer-related morbidities, and increase mortality. Continued research is needed to further determine and refine how timing and degree of such exposures in early childhood and adolescence relate to adult cancer risk. Presently, sufficient evidence suggests a continued need for stronger primary prevention in cancer and obesity research via modified lifestyle behaviors earlier in the developmental spectrum, i.e. during childhood and adolescence.}, Language = {eng}, Doi = {10.1159/000220605}, Key = {fds272717} } @article{fds304101, Author = {Quinlan, NP and Kolotkin, RL and Fuemmeler, BF and Costanzo, PR}, Title = {Psychosocial outcomes in a weight loss camp for overweight youth.}, Journal = {International Journal of Pediatric Obesity (Informa)}, Volume = {4}, Number = {3}, Pages = {134-142}, Year = {2009}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19107660}, Abstract = {OBJECTIVE: There is good evidence that youth attending weight loss camps in the UK and US are successful at achieving weight loss. Limited research suggests improvement in body image and self-esteem as well. This study evaluated changes in eight psychosocial variables following participation in a weight loss camp and examined the role of gender, age, length of stay, and body mass index (BMI) in these changes. METHODS: This was an observational and self-report study of 130 participants (mean age = 12.8; mean BMI = 33.5; 70% female; 77% Caucasian). The program consisted of an 1800 kcal/day diet, daily supervised physical activities, cooking/nutrition classes, and weekly psycho-educational/support groups led by psychology staff. Participants completed measures of anti-fat attitudes, values (e.g., value placed on appearance, athletic ability, popularity), body- and self-esteem, weight- and health-related quality of life, self-efficacy, and depressive symptoms. RESULTS: Participants experienced significant BMI reduction (average decrease of 7.5 kg [standard deviation, SD = 4.2] and 2.9 BMI points [SD = 1.4]). Participants also exhibited significant improvements in body esteem, self-esteem, self-efficacy, generic and weight-related quality of life, anti-fat attitudes, and the importance placed on appearance. Changes in self-efficacy, physical functioning and social functioning remained significant even after adjusting for initial zBMI, BMI change, and length of stay. Gender differences were found on changes in self-efficacy, depressive symptoms, and social functioning. CONCLUSION: Participation in weight loss programs in a group setting, such as a camp, may have added benefit beyond BMI reduction. Greater attention to changes in psychosocial variables may be warranted when designing such programs for youth.}, Doi = {10.1080/17477160802613372}, Key = {fds304101} } @article{fds272722, Author = {Quinlan, NP and Kolotkin, RL and Fuemmeler, BF and Costanzo, PR}, Title = {Psychosocial outcomes in a weight loss camp for overweight youth.}, Journal = {International Journal of Pediatric Obesity (Informa)}, Volume = {4}, Number = {3}, Pages = {1-9}, Year = {2008}, Month = {December}, ISSN = {1747-7174}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19107660}, Keywords = {Adolescent • Attitude • Body Mass Index • Camping • Female • Humans • Male • Overweight • Quality of Life • Self Concept • Sex Characteristics • Weight Loss* • psychology*}, Abstract = {Objective. There is good evidence that youth attending weight loss camps in the UK and US are successful at achieving weight loss. Limited research suggests improvement in body image and self-esteem as well. This study evaluated changes in eight psychosocial variables following participation in a weight loss camp and examined the role of gender, age, length of stay, and body mass index (BMI) in these changes. Methods. This was an observational and self-report study of 130 participants (mean age=12.8; mean BMI=33.5; 70% female; 77% Caucasian). The program consisted of an 1 800 kcal/day diet, daily supervised physical activities, cooking/nutrition classes, and weekly psycho-educational/support groups led by psychology staff. Participants completed measures of anti-fat attitudes, values (e.g., value placed on appearance, athletic ability, popularity), body- and self-esteem, weight- and health-related quality of life, self-efficacy, and depressive symptoms. Results. Participants experienced significant BMI reduction (average decrease of 7.5 kg [standard deviation, SD=4.2] and 2.9 BMI points [SD=1.4]). Participants also exhibited significant improvements in body esteem, self-esteem, self-efficacy, generic and weight-related quality of life, anti-fat attitudes, and the importance placed on appearance. Changes in self-efficacy, physical functioning and social functioning remained significant even after adjusting for initial zBMI, BMI change, and length of stay. Gender differences were found on changes in self-efficacy, depressive symptoms, and social functioning. Conclusion. Participation in weight loss programs in a group setting, such as a camp, may have added benefit beyond BMI reduction. Greater attention to changes in psychosocial variables may be warranted when designing such programs for youth.}, Language = {eng}, Doi = {10.1080/17477160802613372}, Key = {fds272722} } @article{fds272725, Author = {Mosher, CE and Fuemmeler, BF and Sloane, R and Kraus, WE and Lobach, DF and Snyder, DC and Demark-Wahnefried, W}, Title = {Change in self-efficacy partially mediates the effects of the FRESH START intervention on cancer survivors' dietary outcomes.}, Journal = {Psycho Oncology}, Volume = {17}, Number = {10}, Pages = {1014-1023}, Year = {2008}, Month = {October}, ISSN = {1099-1611}, url = {http://www.ncbi.nlm.nih.gov/pubmed/18300337}, Keywords = {Breast Neoplasms • Energy Intake • Exercise • Female • Follow-Up Studies • Food Habits* • Health Behavior* • Humans • Male • Middle Aged • Neoplasms • Prostatic Neoplasms • Questionnaires • Self Efficacy* • Survivors • psychology*}, Abstract = {This study examined change in self-efficacy as a mediator of the effects of a mailed print intervention on the dietary and exercise practices of newly diagnosed breast and prostate cancer survivors.A total of 543 breast and prostate cancer patients were recruited from 39 states and two provinces within North America. Participants were randomly assigned to receive a 10-month program of tailored mailed print materials that aimed to increase fruit and vegetable consumption, reduce fat intake, and/or increase exercise or a 10-month program of publically available materials on diet and exercise. Telephone surveys conducted at baseline and 1 year assessed dietary practices, physical activity, and self-efficacy for engaging in these health behaviors.Results indicated that changes in self-efficacy for fat restriction and eating more fruits and vegetables were significant mediators of the intervention's effects on dietary outcomes at 1-year follow-up. The intervention did not significantly affect self-efficacy for exercise; however, a significant, positive relationship was found between self-efficacy for exercise and exercise duration at follow-up.Findings are largely consistent with Social Cognitive Theory and support the use of strategies to increase self-efficacy in health promotion interventions for cancer survivors.}, Language = {eng}, Doi = {10.1002/pon.1327}, Key = {fds272725} } @article{fds272724, Author = {Chang, S and Mâsse, LC and Moser, RP and Dodd, KW and Arganaraz, F and Fuemmler, BF and Jemal, A}, Title = {State ranks of incident cancer burden due to overweight and obesity in the United States, 2003.}, Journal = {Obesity (Silver Spring, Md.)}, Volume = {16}, Number = {7}, Pages = {1636-1650}, Year = {2008}, Month = {July}, ISSN = {1930-7381}, url = {http://www.ncbi.nlm.nih.gov/pubmed/18421271}, Keywords = {Adult • Behavioral Risk Factor Surveillance System • Censuses • Cross-Sectional Studies • Female • Humans • Incidence • Male • Neoplasms • Obesity • Overweight • Prevalence • Residence Characteristics • Risk Factors • SEER Program • United States • complications* • epidemiology • epidemiology* • etiology*}, Abstract = {OBJECTIVE: Given links between obesity and cancer, we estimated incident cancer burden due to overweight and obesity at the state level in the United States. METHODS AND PROCEDURES: Using state rankings by per capita burden of incident cancer cases diagnosed in 2003 that were related to overweight and obesity, we examined the frequency with which states ranked in the highest and lowest quintiles of weight-related burden for cancers of the postmenopausal breast, endometrium, kidney, colon, and prostate. In this study, data from the Behavioral Risk Factor Surveillance System (BRFSS), US Census, US Mortality Public Use Data Tapes, and National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) Program were used. RESULTS: Western states had the lowest weight-related cancer burden for both sexes. Iowa, South Dakota, and West Virginia had the highest burden for all three types of male cancers. West Virginia is the only state that ranked in the quintile of highest weight-related burden for all four cancers considered in women. DISCUSSION: For certain cancers, including endometrial, postmenopausal breast, and colon cancers, states with high burdens clustered in geographic regions, warranting further inquiry. Although state ranks for the total cancer burden and the prevalence of overweight and obesity correlated with state ranks for weight-related incident cancer burden, they often served poorly as its proxy. Such a finding cautions against simply targeting states with high overweight and obesity or high total burdens of cancers for which overweight and obesity are risk factors, as this approach may not reach areas of unrecognized burden.}, Language = {eng}, Doi = {10.1038/oby.2008.228}, Key = {fds272724} } @article{fds272726, Author = {Roberts, ME and Fuemmeler, BF and McClernon, FJ and Beckham, JC}, Title = {Association between trauma exposure and smoking in a population-based sample of young adults.}, Journal = {Journal of Adolescent Health}, Volume = {42}, Number = {3}, Pages = {266-274}, Year = {2008}, Month = {March}, ISSN = {1879-1972}, url = {http://www.ncbi.nlm.nih.gov/pubmed/18295135}, Keywords = {Adolescent • Adolescent Behavior* • Adult • Age Distribution • Causality • Cohort Studies • Comorbidity • Crime Victims • Female • Humans • Logistic Models • Longitudinal Studies • Male • Multivariate Analysis • Odds Ratio • Prevalence • Sex Offenses • Smoking • Socioeconomic Factors • United States • Violence • epidemiology • epidemiology* • statistics & numerical data*}, Abstract = {To evaluate the relation between smoking and trauma exposure in a population-based, longitudinal sample. Contrary to current smoking trends in the general population, recent findings indicate continued high smoking rates in trauma-exposed samples.A nationally representative sample of 15,197 adolescents was followed from 1995 (mean age, 15.6 years) to 2002 (mean age, 22 years) as part of three waves of The National Longitudinal Study of Adolescent Health (Add Health). We examined the relation between self-reported trauma exposure and smoking behaviors (lifetime regular, current regular), nicotine dependence based on the Fagerström Test of Nicotine Dependence (FTND), number of cigarettes smoked per day, and age of onset of regular smoking.Controlling for demographics and depressive symptoms, exposure to traumatic events yielded a significant increase in the odds of lifetime regular smoking. Nicotine dependence and cigarettes smoked per day was also significantly related to exposure to childhood physical and sexual abuse. Decreased age of regular smoking onset was seen for those reporting childhood physical abuse and childhood sexual abuse.Exposure to traumatic life events during childhood and young adulthood increases the risk of smoking, highlighting the need to prevent and treat tobacco use in this vulnerable population.}, Language = {eng}, Doi = {10.1016/j.jadohealth.2007.08.029}, Key = {fds272726} } @article{fds272728, Author = {Fuemmeler, BF and Agurs-Collins, TD and McClernon, FJ and Kollins, SH and Kail, ME and Bergen, AW and Ashley-Koch, AE}, Title = {Genes implicated in serotonergic and dopaminergic functioning predict BMI categories.}, Journal = {Obesity (Silver Spring, Md.)}, Volume = {16}, Number = {2}, Pages = {348-355}, Year = {2008}, Month = {February}, ISSN = {1930-7381}, url = {http://www.ncbi.nlm.nih.gov/pubmed/18239643}, Keywords = {Adolescent • Adult • Aging • Body Mass Index* • Cohort Studies • Dopamine • Dopamine Plasma Membrane Transport Proteins • Energy Metabolism • European Continental Ancestry Group • Female • Hispanic Americans • Humans • Logistic Models • Longitudinal Studies • Male • Monoamine Oxidase • Obesity • Predictive Value of Tests • Receptors, Dopamine D4 • Serotonin • Serotonin Plasma Membrane Transport Proteins • Sex Characteristics • ethnology • genetics • genetics* • metabolism • metabolism* • physiology • physiopathology}, Abstract = {OBJECTIVE: This study addressed the hypothesis that variation in genes associated with dopamine function (SLC6A3, DRD2, DRD4), serotonin function (SLC6A4, and regulation of monoamine levels (MAOA) may be predictive of BMI categories (obese and overweight + obese) in young adulthood and of changes in BMI as adolescents transition into young adulthood. Interactions with gender and race/ethnicity were also examined. METHODS AND PROCEDURES: Participants were a subsample of individuals from the National Longitudinal Study of Adolescent Health (Add Health), a nationally representative sample of adolescents followed from 1995 to 2002. The sample analyzed included a subset of 1,584 unrelated individuals with genotype data. Multiple logistic regressions were conducted to evaluate the associations between genotypes and obesity (BMI > 29.9) or overweight + obese combined (BMI > or = 25) with normal weight (BMI = 18.5-24.9) as a referent. Linear regression models were used to examine change in BMI from adolescence to young adulthood. RESULTS: Significant associations were found between SLC6A4 5HTTLPR and categories of BMI, and between MAOA promoter variable number tandem repeat (VNTR) among men and categories of BMI. Stratified analyses revealed that the association between these two genes and excess BMI was significant for men overall and for white and Hispanic men specifically. Linear regression models indicated a significant effect of SLC6A4 5HTTLPR on change in BMI from adolescence to young adulthood. DISCUSSION: Our findings lend further support to the involvement of genes implicated in dopamine and serotonin regulation on energy balance.}, Language = {eng}, Doi = {10.1038/oby.2007.65}, Key = {fds272728} } @article{fds272727, Author = {McClernon, FJ and Fuemmeler, BF and Kollins, SH and Kail, ME and Ashley-Koch, AE}, Title = {Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults.}, Journal = {Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco}, Volume = {10}, Number = {1}, Pages = {117-127}, Year = {2008}, Month = {January}, ISSN = {1462-2203}, url = {http://www.ncbi.nlm.nih.gov/pubmed/18188752}, Keywords = {Adolescent • Adult • Aryl Hydrocarbon Hydroxylases • Attention Deficit Disorder with Hyperactivity • Comorbidity • Dopamine Plasma Membrane Transport Proteins • Female • Genetic Predisposition to Disease • Humans • Impulse Control Disorders • Longitudinal Studies • Male • Mixed Function Oxygenases • Polymorphism, Genetic* • Receptors, Dopamine D2 • Receptors, Dopamine D3 • Receptors, Dopamine D4 • Retrospective Studies • Risk Factors • Serotonin Plasma Membrane Transport Proteins • Smoking • epidemiology* • genetics • genetics*}, Abstract = {Attention-deficit/hyperactivity disorder (ADHD) symptoms are associated with an increased risk of smoking, and genetic studies have identified similar candidate genes associated with both ADHD and smoking phenotypes. This paper addresses the question of whether ADHD symptoms interact with candidate gene variation to predict smoking risk. Participants were a subsample of individuals from the National Longitudinal Study of Adolescent Health (Add Health), a nationally representative sample of adolescents followed from 1995 to 2002. The sample analyzed included a subset from Add Health of 1,900 unrelated individuals with genotype data. Multiple logistic regression was used to examine relationships between self-reported ADHD symptoms, genotype, and lifetime history of regular smoking. Polymorphisms in the DRD2 gene and, among females, the MAOA gene interacted with retrospective reports of ADHD symptoms in contributing to risk for smoking. Trends were observed for interactions between the DRD4 gene and, among males, the MAOA gene and ADHD symptoms to predict smoking risk. No main effect for any of these polymorphisms was observed. We observed neither main effects nor interactions with CYP2A6, DAT, and SLC6A4 genes. These findings suggest that genotypes associated with catecholamine neurotransmission interact with ADHD symptoms to contribute to smoking risk.}, Language = {eng}, Doi = {10.1080/14622200701704913}, Key = {fds272727} } @article{fds272689, Author = {Anderson, CB and Hughes, SO and Fuemmeler, BF}, Title = {CHILD PHYSICAL ACTIVITY AND PARENT-CHILD ATTITUDE CONGRUENCE ON ATHLETIC COMPETENCE AND ACTIVITY TYPE}, Journal = {Annals of Behavioral Medicine}, Volume = {33}, Pages = {S201-S201}, Year = {2007}, Month = {December}, ISSN = {0883-6612}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000261185300787&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds272689} } @article{fds272736, Author = {Fuemmeler, BF and Kollins, SH and McClernon, FJ}, Title = {Attention deficit hyperactivity disorder symptoms predict nicotine dependence and progression to regular smoking from adolescence to young adulthood.}, Journal = {Journal of Pediatric Psychology}, Volume = {32}, Number = {10}, Pages = {1203-1213}, Year = {2007}, Month = {November}, ISSN = {0146-8693}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17602186}, Keywords = {Adolescent • Adult • Attention Deficit Disorder with Hyperactivity • Disease Progression • Disease Susceptibility • Female • Humans • Male • Regression Analysis • Retrospective Studies • Risk Factors • Smoking • Tobacco Use Disorder • United States • epidemiology • epidemiology* • prevention & control • psychology}, Abstract = {OBJECTIVE: To examine the association between retrospectively reported attention deficit hyperactivity disorder (ADHD) symptoms and progression to smoking and the association with nicotine dependence. METHODS: Study sample consisted of a nationally representative cohort of U.S. adolescents (n = 13,494). Logistic regression was used to examine ADHD symptoms from both the inattentive (IN) and hyperactive-impulsive (HI) domains and smoking trajectories. Linear regression was used to examine nicotine dependence. RESULTS: HI symptoms were associated with progression from nonsmoking to regular smoking (OR = 1.14, 95% CI = 1.07-1.21), and with progression from experimentation to regular smoking (OR = 1.16, 95% CI = 1.08-1.26). IN and HI symptoms were associated with nicotine dependence among current smokers (IN: beta = 0.17, SE = 0.03, p < 0.0001; HI: beta = 0.10, SE = 0.04., p < .001). CONCLUSIONS: These results have important implications for the development of prevention and treatment modalities.}, Language = {eng}, Doi = {10.1093/jpepsy/jsm051}, Key = {fds272736} } @article{fds272723, Author = {Brown, RT and Fuemmeler, B and Anderson, D and Jamieson, S and Simonian, S and Hall, RK and Brescia, F}, Title = {Adjustment of children and their mothers with breast cancer.}, Journal = {Journal of Pediatric Psychology}, Volume = {32}, Number = {3}, Pages = {297-308}, Year = {2007}, Month = {April}, ISSN = {0146-8693}, url = {http://www.ncbi.nlm.nih.gov/pubmed/16837738}, Keywords = {Adaptation, Psychological* • Adult • Breast Neoplasms • Child • Child Behavior • Female • Humans • Male • Mother-Child Relations • Mothers • Social Adjustment* • Social Support • psychology*}, Abstract = {OBJECTIVE: To examine the adjustment of children of mothers with both active and nonactive breast cancers in comparison with a healthy community control sample. METHODS: Participants included 80 mothers and their children. Half of the mothers had breast cancer or a history of breast cancer. Children in both groups ranged in age from 8 to 19 years. Assessments included measures of maternal stressors and resources, maternal and child adjustment and posttraumatic stress, and maternal coping and illness uncertainty reported by both mothers and their children. RESULTS: Few differences were found between the groups, although there was a trend for girls of mothers with breast cancer to have a higher frequency of depressive symptoms. Children of mothers who perceived support from friends and family had fewer depressive symptoms, after we controlled for child gender. CONCLUSIONS: The social support perceived by mothers with breast cancer may serve as a protective factor for their children's psychological adjustment.}, Language = {eng}, Doi = {10.1093/jpepsy/jsl015}, Key = {fds272723} } @article{fds272737, Author = {Fuemmeler, BF and Baffi, C and Mâsse, LC and Atienza, AA and Evans, WD}, Title = {Employer and healthcare policy interventions aimed at adult obesity.}, Journal = {American Journal of Preventive Medicine}, Volume = {32}, Number = {1}, Pages = {44-51}, Year = {2007}, Month = {January}, ISSN = {0749-3797}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17218190}, Keywords = {Adolescent • Adult • Aged • Attitude to Health • Data Collection • Female • Health Policy* • Humans • Male • Middle Aged • Obesity • United States • Workplace* • economics • etiology • prevention & control*}, Abstract = {BACKGROUND: Increasing rates of obesity in the population have made prevention a high public health priority. Policy strategies for curtailing obesity have been recommended, yet there has been little research on the degree of public support for policy-level interventions. METHODS: Participants for this study included 1139 respondents who were surveyed as part of the Research Triangle Institute Obesity Telephone Survey conducted in September 2004. Participants were asked to indicate to what degree they favor specific healthcare and work policy strategies for treating and preventing adult obesity. Participants were also asked about their beliefs regarding the causes of obesity. RESULTS: A majority (85%) favored a policy change strategy that offered employers tax breaks if they provided adequate exercise facilities in the workplace. Seventy-three percent favored a move by healthcare companies to require obesity treatment and prevention. The same proportion (72%) favored beneficiary discounts by employers or healthcare companies to motivate individuals to maintain or move toward a healthy weight. Majorities endorsed a lack of willpower and the cost of healthy food as causes. Nearly two thirds did not believe genes or lack of knowledge was related to obesity in society, and the sample was split with regard to the belief that obesity is caused by society. CONCLUSIONS: The findings suggest that there is strong support for healthcare and employment policies in obesity prevention and treatment. These findings may be important to policymakers in developing population-based strategies to prevent obesity.}, Language = {eng}, Doi = {10.1016/j.amepre.2006.09.003}, Key = {fds272737} } @article{fds72463, Title = {Fuemmeler BF. Disease. In W.A. Darity (Ed.). International Encyclopedia of the Social Sciences, Second Edition. Farmington Hills, Mich.: Macmillan Reference USA, November 2007}, Year = {2007}, Key = {fds72463} } @article{fds72464, Title = {Brown, RT, Fuemmeler, BF, Anderson, D, Jamieson, S, Simonian, S, Brescia, F. Adjustment of children and their mothers with breast cancer. Journal of Pediatric Psychology. 2007, 32, 297 – 308.}, Year = {2007}, Key = {fds72464} } @article{fds72467, Title = {Fuemmeler BF. Panel Study. In W.A. Darity (Ed.). International Encyclopedia of the Social Sciences, Second Edition. Farmington Hills, Mich.: Macmillan Reference USA, November 2007}, Year = {2007}, Key = {fds72467} } @article{fds272703, Author = {Metz, AE and Fuemmeler, BF and Brown, RT}, Title = {Implementation and assessment of an empirically validated intervention program to prevent Tobacco use among African-American middle-school youth}, Journal = {Journal of Clinical Psychology in Medical Settings}, Volume = {13}, Number = {3}, Pages = {229-238}, Publisher = {Springer Nature}, Year = {2006}, Month = {September}, ISSN = {1068-9583}, url = {http://dx.doi.org/10.1007/s10880-006-9031-x}, Abstract = {Evaluated Project Towards No Tobacco Use (TNT), a tobacco-use prevention program delivered in schools with primarily African-American students. Students randomly by classroom to either the intervention (n=58) or to a no-treatment control group (n=40). Students in the intervention grup recieved a curriculum-based program over the course of 10 sessions. Pre-and-assestment of tobacco knowledge, attitudes, communication, peer refusal, and smoking tendency were gathered. Students in the intervention group differed from their peers in the control group by evidencing greater knowledge and communication skills. We found this tobacco-use prevention program useful for African-american students. © Springer Science+Business Media, Inc. 2006.}, Doi = {10.1007/s10880-006-9031-x}, Key = {fds272703} } @article{fds272721, Author = {Elkin, TD and Wollan, MO and Anderson, SL and Gaston, R and Meyer, W and Fuemmeler, BF and Holloway, FA and Martin, RE}, Title = {Dietary essential fatty acids and gender-specific behavioral responses in cranially irradiated rats.}, Journal = {Neuropsychiatric Disease and Treatment}, Volume = {2}, Number = {3}, Pages = {365-374}, Year = {2006}, Month = {September}, ISSN = {1176-6328}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19412484}, Abstract = {Specific memory deficits, reduced intellectual processing speed, and a variety of social and behavioral problems have been implicated as long-term effects of cranial radiation therapy (CRT). These deficits are thought to be related to changes in brain cytology and structure associated with microvascular aberrations. N-3 fatty acids may serve as protectants in pediatric patients who receive CRT for brain tumors. Timed-pregnant rat dams were fed one of four diets that were identical in all respects, except for their essential fatty acid content. The dams were placed on these diets at the beginning of the third trimester of gestation and their pups remained on them throughout the study. The rats' behavioral response as judged by acoustic startle response (ASR) and neurocognitive response (performance in a radial maze, RM) were evaluated in relation to diet, gender, and CRT. The following hypotheses were tested: (1) female rats will show greater CRT-induced neurocognitive and behavioral deficits; (2) dietary n-3 fatty acids will diminish CRT-induced neurocognitive and behavioral deficits; (3) gender-specific differences would be dampened by n-3 fatty acids in the diet. All three hypotheses were partially supported. These findings are discussed in light of the potential neuroprotective effects of n-3 fatty acids.}, Language = {eng}, Key = {fds272721} } @article{fds272732, Author = {Fuemmeler, BF and Mâsse, LC and Yaroch, AL and Resnicow, K and Campbell, MK and Carr, C and Wang, T and Williams, A}, Title = {Psychosocial mediation of fruit and vegetable consumption in the body and soul effectiveness trial.}, Journal = {Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association}, Volume = {25}, Number = {4}, Pages = {474-483}, Year = {2006}, Month = {July}, ISSN = {0278-6133}, url = {http://www.ncbi.nlm.nih.gov/pubmed/16846322}, Keywords = {Feeding Behavior* • Female • Follow-Up Studies • Food Habits • Fruit* • Health Status* • Humans • Male • Mental Health* • Middle Aged • Motivation • Psychology • Questionnaires • Religion • Self Efficacy • Social Support • Vegetables*}, Abstract = {In this study the authors examined psychosocial variables as mediators for fruit and vegetable (FV) intake in a clustered, randomized effectiveness trial conducted in African American churches. The study sample included 14 churches (8 intervention and 6 control) with 470 participants from the intervention churches and 285 participants from the control churches. The outcome of FV intake and the proposed mediators were measured at baseline and at 6-month follow-up. Structural equation modeling indicated that the intervention had direct effects on social support, self-efficacy, and autonomous motivation; these variables also had direct effects on FV intake. Applying the M. E. Sobel (1982) formula to test significant mediated effects, the authors confirmed that social support and self-efficacy were significant mediators but that autonomous motivation was not. Social support and self-efficacy partially mediated 20.9% of the total effect of the intervention on changes in FV intake. The results support the use of strategies to increase social support and self-efficacy in dietary intervention programs.}, Language = {eng}, Doi = {10.1037/0278-6133.25.4.474}, Key = {fds272732} } @article{fds72457, Title = {Fuemmeler, B. F., Mullins, L. L, & Carpentier, M. (2006). Peer friendship issues and emotional well-being. In R. T. Brown (Ed.). Pediatric Hematology/Oncology: A Biopsychosocial Approach. Oxford University Press. }, Year = {2006}, Key = {fds72457} } @article{fds72460, Title = {Metz AE, Fuemmeler BF, Brown RT. Implementation and assessment of an empirically validated intervention program to prevent tobacco use among African-American middle school youth. Journal of Clinical Psychology in Medical Settings. 2006, 13, 229-238}, Year = {2006}, Key = {fds72460} } @article{fds272729, Author = {Mâsse, LC and Fuemmeler, BF and Anderson, CB and Matthews, CE and Trost, SG and Catellier, DJ and Treuth, M}, Title = {Accelerometer data reduction: a comparison of four reduction algorithms on select outcome variables.}, Journal = {Medicine and Science in Sports and Exercise}, Volume = {37}, Number = {11 Suppl}, Pages = {S544-S554}, Year = {2005}, Month = {November}, ISSN = {0195-9131}, url = {http://www.ncbi.nlm.nih.gov/pubmed/16294117}, Keywords = {Acceleration* • Adult • Aged • Algorithms* • Female • Human Engineering • Humans • Middle Aged • Statistics as Topic • instrumentation* • methods* • standards}, Abstract = {PURPOSE: Accelerometers are recognized as a valid and objective tool to assess free-living physical activity. Despite the widespread use of accelerometers, there is no standardized way to process and summarize data from them, which limits our ability to compare results across studies. This paper a) reviews decision rules researchers have used in the past, b) compares the impact of using different decision rules on a common data set, and c) identifies issues to consider for accelerometer data reduction. METHODS: The methods sections of studies published in 2003 and 2004 were reviewed to determine what decision rules previous researchers have used to identify wearing period, minimal wear requirement for a valid day, spurious data, number of days used to calculate the outcome variables, and extract bouts of moderate to vigorous physical activity (MVPA). For this study, four data reduction algorithms that employ different decision rules were used to analyze the same data set. RESULTS: The review showed that among studies that reported their decision rules, much variability was observed. Overall, the analyses suggested that using different algorithms impacted several important outcome variables. The most stringent algorithm yielded significantly lower wearing time, the lowest activity counts per minute and counts per day, and fewer minutes of MVPA per day. An exploratory sensitivity analysis revealed that the most stringent inclusion criterion had an impact on sample size and wearing time, which in turn affected many outcome variables. CONCLUSIONS: These findings suggest that the decision rules employed to process accelerometer data have a significant impact on important outcome variables. Until guidelines are developed, it will remain difficult to compare findings across studies.}, Language = {eng}, Doi = {10.1249/01.mss.0000185674.09066.8a}, Key = {fds272729} } @article{fds319632, Author = {Mâsse, LC and Fuemmeler, BF and Anderson, CB and Matthews, CE and Trost, SG and Catellier, DJ and Treuth, M}, Title = {Accelerometer data reduction: A comparison of four reduction algorithms on select outcome variables}, Journal = {Medicine and Science in Sports and Exercise}, Volume = {37}, Number = {11 SUPPL.}, Pages = {S544-S554}, Publisher = {Ovid Technologies (Wolters Kluwer Health)}, Year = {2005}, Month = {November}, url = {http://dx.doi.org/10.1249/01.mss.0000185674.09066.8a}, Abstract = {Purpose: Accelerometers are recognized as a valid and objective tool to assess free-living physical activity. Despite the widespread use of accelerometers, there is no standardized way to process and summarize data from them, which limits our ability to compare results across studies. This paper a) reviews decision rules researchers have used in the past, b) compares the impact of using different decision rules on a common data set, and c) identifies issues to consider for accelerometer data reduction. Methods: The methods sections of studies published in 2003 and 2004 were reviewed to determine what decision rules previous researchers have used to identify wearing period, minimal wear requirement for a valid day, spurious data, number of days used to calculate the outcome variables, and extract bouts of moderate to vigorous physical activity (MVPA). For this study, four data reduction algorithms that employ different decision rules were used to analyze the same data set. Results: The review showed that among studies that reported their decision rules, much variability was observed. Overall, the analyses suggested that using different algorithms impacted several important outcome variables. The most stringent algorithm yielded significantly lower wearing time, the lowest activity counts per minute and counts per day, and fewer minutes of MVPA per day. An exploratory sensitivity analysis revealed that the most stringent inclusion criterion had an impact on sample size and wearing time, which in turn affected many outcome variables. Conclusions: These findings suggest that the decision rules employed to process accelerometer data have a significant impact on important outcome variables. Until guidelines are developed, it will remain difficult to compare findings across studies. Copyright © 2005 by the American College of Sports Medicine.}, Doi = {10.1249/01.mss.0000185674.09066.8a}, Key = {fds319632} } @article{fds272734, Author = {Kollins, SH and McClernon, FJ and Fuemmeler, BF}, Title = {Association between smoking and attention-deficit/hyperactivity disorder symptoms in a population-based sample of young adults.}, Journal = {Archives of General Psychiatry}, Volume = {62}, Number = {10}, Pages = {1142-1147}, Year = {2005}, Month = {October}, ISSN = {0003-990X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/16203959}, Keywords = {Adolescent • Adult • Age of Onset • Attention Deficit Disorder with Hyperactivity • Cognition Disorders • Comorbidity • Female • Follow-Up Studies • Health Surveys • Humans • Impulse Control Disorders • Longitudinal Studies • Male • Retrospective Studies • Risk Factors • Smoking • Tobacco Use Disorder • diagnosis • epidemiology • epidemiology* • psychology}, Abstract = {CONTEXT: Attention-deficit/hyperactivity disorder (ADHD) has been associated with increased risk of smoking, and some studies have suggested that inattentive symptoms specifically may underlie this risk. Few studies, however, have examined ADHD symptoms in nonclinical samples to determine the extent to which the number of symptoms-independent of the full diagnosis-confer risk for smoking-related outcomes. OBJECTIVE: To evaluate the relation between smoking-related variables and the number of retrospectively reported ADHD inattentive and hyperactive/impulsive symptoms in a population-based sample of young adults. DESIGN, SETTING, AND PARTICIPANTS: The study population consists of 15 197 eligible participants from wave III of the National Longitudinal Study of Adolescent Health, a nationally representative sample of adolescents followed from 1995 to 2002. MAIN OUTCOME MEASURES: Logistic regression was used to examine the relation between self-reported ADHD symptoms and the lifetime likelihood of being a regular smoker, defined by having smoked at least 1 cigarette a day for 30 days. For individuals reporting regular smoking, we also examined the extent to which ADHD symptoms predicted age at onset of regular smoking and number of cigarettes smoked. RESULTS: A linear relation was identified between the number of self-reported inattentive and hyperactive/impulsive symptoms and smoking outcome measures (P<.001 for each symptom domain). Controlling for demographic and conduct disorder symptoms, each reported inattention and hyperactivity/impulsivity symptom significantly increased the likelihood of ever regular smoking (odds ratio [OR], 1.11; 95% confidence interval [CI], 1.08-1.14 and OR, 1.16; 95% CI, 1.13-1.19, respectively). For those reporting lifetime regular smoking, reported symptoms decreased the estimated age at onset and increased the number of cigarettes smoked. CONCLUSIONS: Self-reported ADHD symptoms were found to be associated with adult smoking outcome variables in this nationally representative sample, providing further evidence of a likely link between ADHD symptoms and risk for tobacco use.}, Language = {eng}, Doi = {10.1001/archpsyc.62.10.1142}, Key = {fds272734} } @article{fds272701, Author = {Fuemmeler, BF and Mullins, LL and Van Pelt and J and Carpentier, MY and Parkhurst, J}, Title = {Posttraumatic stress symptoms and distress among parents of children with cancer}, Journal = {Children'S Health Care}, Volume = {34}, Number = {4}, Pages = {289-303}, Publisher = {Informa UK Limited}, Year = {2005}, Month = {January}, ISSN = {0273-9615}, url = {http://dx.doi.org/10.1207/s15326888chc3404_4}, Abstract = {In this study, we compared levels of posttraumatic stress symptoms (PTSS) and general psychological distress between parents of childhood cancer survivors and parents of children with Type 1 diabetes mellitus (DM1). In this study, we also examined potential risk factors for PTSS. Participants included 47 parents of childhood cancer survivors and 31 parents of children with DM1. Participants completed self-report measures of posttraumatic stress, general psychological distress, coping strategies, social network size, and perceived illness uncertainty. Findings revealed that parents of children surviving cancer reported higher levels of PTSS and general distress than parents of children with DM1. In the total sample, lower levels of emotion-focused coping and greater perceived uncertainty were associated with increased frequency of both PTSS and general psychological distress after we accounted for demographic and illness variables. Having a child with cancer may increase the risk for experiencing PTSS. Interventions are warranted that focus specifically on the reduction of PTSS in parents of children surviving cancer. Copyright © 2005, Lawrence Erlbaum Associates, Inc.}, Doi = {10.1207/s15326888chc3404_4}, Key = {fds272701} } @article{fds272735, Author = {Meyer, EA and Fuemmeler, BF}, Title = {Commentary: psychosocial functioning of children and adolescents surviving cancer: the junior investigators' perspective.}, Journal = {Journal of Pediatric Psychology}, Volume = {30}, Number = {1}, Pages = {47-49}, Year = {2005}, Month = {January}, ISSN = {0146-8693}, url = {http://www.ncbi.nlm.nih.gov/pubmed/15610984}, Keywords = {Adaptation, Psychological • Adolescent • Child • Disease-Free Survival • Health Behavior • Humans • Neoplasms • Psychology • Social Behavior* • methods* • psychology* • therapy*}, Language = {eng}, Key = {fds272735} } @article{fds72450, Title = {Fuemmeler, B. F., Mullins, L. L., Van Pelt, J., Carpentier, M. Y., & Parkhurst, J. (2005). Posttraumatic stress symptoms and distress among parents of children with cancer. Children’s Health Care, 34 (4), 289 - 304.}, Year = {2005}, Key = {fds72450} } @article{fds272730, Author = {Fuemmeler, BF}, Title = {Bridging disciplines: an introduction to the special issue on public health and pediatric psychology.}, Journal = {Journal of Pediatric Psychology}, Volume = {29}, Number = {6}, Pages = {405-414}, Year = {2004}, Month = {September}, ISSN = {0146-8693}, url = {http://www.ncbi.nlm.nih.gov/pubmed/15277584}, Keywords = {Child Psychology* • Health Policy • Humans • Interdisciplinary Communication* • Preventive Health Services • Public Health Practice* • Research • United States • organization & administration • organization & administration*}, Language = {eng}, Doi = {10.1093/jpepsy/jsh045}, Key = {fds272730} } @article{fds272733, Author = {Wiecha, JL and El Ayadi and AM and Fuemmeler, BF and Carter, JE and Handler, S and Johnson, S and Strunk, N and Korzec-Ramirez, D and Gortmaker, SL}, Title = {Diffusion of an integrated health education program in an urban school system: planet health.}, Journal = {Journal of Pediatric Psychology}, Volume = {29}, Number = {6}, Pages = {467-474}, Year = {2004}, Month = {September}, ISSN = {0146-8693}, url = {http://www.ncbi.nlm.nih.gov/pubmed/15277589}, Keywords = {Boston • Consumer Participation* • Diffusion of Innovation* • Health Education • Health Plan Implementation • Humans • Obesity • Pilot Projects • School Health Services • Urban Population • methods • organization & administration* • prevention & control*}, Abstract = {OBJECTIVE: Assessed the feasibility, acceptability, and sustainability of Planet Health, an interdisciplinary, integrated health education curriculum implemented in six public middle schools. METHODS: Workshops on Planet Health implementation were attended by 129 teachers (language arts, math, science, and social studies) over three school years (1999-2000, 2000-2001, and 2001-2002). Questionnaires were administered post-implementation and in the fall and spring of each year. Outcomes were dose, acceptability, feasibility, and intent to continue use. RESULTS: The average number of lessons taught per teacher per year was 1.7 to 3.1, compared to a goal of 2 to 3. Each year, teachers reported high acceptability and perceived feasibility of the intervention, and the majority indicated they intended to continue using the curriculum. CONCLUSIONS: Planet Health was feasible and acceptable in a participatory research model involving a public school-university partnership, and it was also sustainable independent of the research effort.}, Language = {eng}, Doi = {10.1093/jpepsy/jsh050}, Key = {fds272733} } @article{fds272700, Author = {Mullins, LL and Fuemmeler, BF and Hoff, A and Chaney, JM and Van Pelt, J and Ewing, CA}, Title = {The Relationship of Parental Overprotection and Perceived Child Vulnerability to Depressive Symptomotology in Children with Type 1 Diabetes Mellitus: The Moderating Influence of Parenting Stress}, Journal = {Children'S Health Care}, Volume = {33}, Number = {1}, Pages = {21-34}, Publisher = {Informa UK Limited}, Year = {2004}, Month = {January}, url = {http://dx.doi.org/10.1207/s15326888chc3301_2}, Abstract = {Our study examined the relationship between parental overprotection and perceived child vulnerability to self-reported depressive symptoms in 8- to 12-year-old children diagnosed with type 1 Diabetes Mellitus. The moderating influence of parenting stress was also examined. Mothers (N = 43) completed measures of parental over-protection, perceived child vulnerability, and parenting stress, and the children completed a measure of child depression. Findings revealed that both child vulnerability and parenting stress were associated with higher levels of depressive symptoms; no relationship was found between overprotection and child depressive symptoms. Regression results further indicated that parenting stress moderated the relationship between perceived child vulnerability and depressive symptomotology. Thus, parenting stress appears to magnify the relationship between perceived child vulnerability and child-reported depressive symptoms. Our findings lend additional empirical support for the transactional relationship between discrete parenting variables and child distress. These results also support the view that overprotection and child vulnerability are distinct but overlapping constructs. Interventions that target specific parenting approaches and general parenting stress may be effective in ameliorating child distress.}, Doi = {10.1207/s15326888chc3301_2}, Key = {fds272700} } @article{fds72458, Title = {Fuemmeler, B. F. (2004). Promotion of Health Behaviors. In R. T. Brown (Ed). Handbook of Pediatric Psychology in the School Setting (pp. 81-98). Englewood Cliffs, NJ: Lawrence Earlbaum}, Year = {2004}, Key = {fds72458} } @article{fds72451, Title = {Mullins, L. L, Fuemmeler, B. F., Hoff, A., Chaney, J. M., Van Pelt, J., Ewing, C. A. (2004). The relationship of parental overprotection and perceived child vulnerability to depressive symptomotology in children with type 1 diabetes mellitus: The moderating influence of parenting stress. Children’s Health Care, 33, 21-34.}, Year = {2004}, Key = {fds72451} } @article{fds272699, Author = {Fuemmeler, BF and Brown, RT and Williams, L and Barredo, J}, Title = {Adjustment of Children With Cancer and Their Caregivers: Moderating Influences of Family Functioning}, Journal = {Families, Systems & Health : the Journal of Collaborative Family Healthcare}, Volume = {21}, Number = {3}, Pages = {263-276}, Publisher = {American Psychological Association (APA)}, Year = {2003}, Month = {September}, url = {http://dx.doi.org/10.1037/1091-7527.21.3.263}, Abstract = {This study examined the associations between repressive adaptation (characterized by low levels of self-reported distress, high levels of defensive responding, and high levels of restraint) and perceived family functioning on the self-reported adjustment of children with cancer and their caregivers. Perceived quality of family relationships and supportiveness among family members were examined as a potential moderator on the association between repressive adaptation and self-reported adjustment. Participants were 58 children surviving cancer and their caregivers. We conducted a multiple regression analysis to determine if perceived family relationships characterized by support would buffer the influence of repressive adaptation on self-reported adjustment difficulties. Results showed that the variable of perceived family relationships characterized by support moderated the association between repressive adaptation and adjustment for caregivers but not for children. Family relationship support served to buffer the negative association that high levels of repressive adaptation have on self-reported adjustment. Recommendations for intervention on a family-systems level are provided as well as directions for future research.}, Doi = {10.1037/1091-7527.21.3.263}, Key = {fds272699} } @article{fds72452, Title = {Fuemmeler, B. F., Brown, R. T., Williams, L. L., & Barredo, J. (2003). Repressive adaptation and adjustment of children with cancer and their caregivers: moderating influences of family functioning. Family, Systems and Health, 21, 263-276.}, Year = {2003}, Key = {fds72452} } @article{fds72459, Title = {Brown, R. T., Fuemmeler, B. F., & Forti, E. M. (2003). Health disparity and access to care. In M. Roberts (Ed), 3rd edition. Handbook of Pediatric Psychology (pp. 683- 695). New York: The Guilford Press}, Year = {2003}, Key = {fds72459} } @article{fds72453, Title = {Fuemmeler, B. F., Taylor, C., Metz, A. E., & Brown, R. T. (2002). Risk taking and smoking tendency among primarily African American school children: moderating influences of peer social pressure. Journal of Clinical Psychology in Medical Settings, 9, 323-330.}, Year = {2002}, Key = {fds72453} } @article{fds72454, Title = {Fuemmeler, B. F., Elkin, T. D., & Mullins, L. L. (2002). Survivors of Childhood Brain Tumors: Behavioral, Emotional, and Social Adjustment. Clinical Psychology Review, 22, 547 - 585. }, Year = {2002}, Key = {fds72454} } @article{fds272698, Author = {Fuemmeler, BF and Taylor, LA and Jr, AEM and Brown, RT}, Title = {Risk-taking and smoking tendency among primarily African American School Children: Moderating influences of peer susceptibility}, Journal = {Journal of Clinical Psychology in Medical Settings}, Volume = {9}, Number = {4}, Pages = {323-330}, Year = {2002}, url = {http://dx.doi.org/10.1023/A:1020743102967}, Abstract = {We examined the hypothesis that peer susceptibility would moderate the association between risk-taking and tendency to smoke in adolescents who were primarily African American. Participants were 88 preadolescents recruited from a 6th grade classroom in a public elementary school. We found an interaction of risk-taking and susceptibility to peer influence on smoking tendency. Specifically, a moderator effect was found for peer influence on the association between risk-taking and smoking tendency. The importance of examining peer susceptibility on health promotion and other health behaviors in children and adolescents was supported.}, Doi = {10.1023/A:1020743102967}, Key = {fds272698} } @article{fds272731, Author = {FUEMMELER, B}, Title = {Survivors of childhood brain tumors : behavioral, emotional, and social adjustment}, Journal = {Clin Psychol Rev}, Volume = {22}, Number = {4}, Pages = {547-585}, Year = {2002}, ISSN = {0272-7358}, url = {http://www.ncbi.nlm.nih.gov/pubmed/12094511}, Keywords = {Adaptation, Psychological* • Brain Neoplasms • Child • Child Behavior • Humans • Quality of Life • Social Adjustment* • Survivors • psychology*}, Abstract = {This paper reviews the literature on the psychological adjustment and quality of life in children who survive brain tumors. A total of 31 studies were reviewed. Findings are discussed in terms of the rates of general psychological adjustment, internalizing behavior problems, externalizing behavior problems, social competence, correlates or predictors of adjustment, and quality of life among survivors. Although these survivors appear to be at risk for compromised social competence and long-term quality of life, reports in the literature on rates of psychological adjustment in this population vary widely. Limitations in the current literature are discussed including inadequate assessment techniques, lack of appropriate comparison groups, and small sample sizes. Directions for future research are offered.}, Language = {eng}, Doi = {10.1016/S0272-7358(01)00120-9}, Key = {fds272731} } @article{fds272696, Author = {Mullins, LL and Cote, MP and Fuemmeler, BF and Jean, VM and Beatty, WW and Paul, RH}, Title = {Illness intrusiveness, uncertainty, and distress in individuals with multiple sclerosis}, Journal = {Rehabilitation Psychology}, Volume = {46}, Number = {2}, Pages = {139-153}, Publisher = {American Psychological Association (APA)}, Year = {2001}, Month = {October}, ISSN = {0090-5550}, url = {http://dx.doi.org/10.1037/0090-5550.46.2.139}, Abstract = {Objective: To examine the relation of illness intrusiveness and illness uncertainty to psychological distress in patients with multiple sclerosis (MS). Study Design: Participants were recruited from regional support groups and local neurologists. Participants completed self-report measures of illness intrusiveness, illness uncertainty, and psychological distress. Disease status was assessed by administration of a mental status exam and an index of ambulation. Participants: The sample included 78 (55 women, 23 men) individuals diagnosed with MS. Main Outcome Measure: The Symptom Checklist - 90 - Revised Global Severity Index. Results: Hierarchical regression analyses indicated that illness intrusiveness and illness uncertainty independently predicted adjustment problems above and beyond demographic and illness variables. No mediator or moderator relationships were found for illness intrusiveness. Conclusions: Psychological appraisals of illness are salient predictors of adjustment even after statistically controlling for the influence of age, education, and objective indices of physical and cognitive impairment.}, Doi = {10.1037/0090-5550.46.2.139}, Key = {fds272696} } @article{fds272697, Author = {Fuemmeler, BF and Mullins, LL and Marx, BP}, Title = {Posttraumatic stress and general distress among parents of children surviving a brain tumor}, Journal = {Children'S Health Care}, Volume = {30}, Number = {3}, Pages = {169-182}, Publisher = {Informa UK Limited}, Year = {2001}, Month = {January}, url = {http://dx.doi.org/10.1207/S15326888CHC3003_1}, Abstract = {In this preliminary study we examined both posttraumatic stress and general distress among parents of children diagnosed with a brain tumor. Participants included 28 parents of children diagnosed with a brain tumor who completed self-report measures of posttraumatic stress, general distress, coping, and illness uncertainty. Findings revealed that participants reported high levels of posttraumatic stress and general distress. Greater levels of emotion-focused coping and perceived uncertainty were associated with a higher frequency of both posttraumatic stress symptoms and general distress. However, perceived uncertainty was the strongest predictor of both indexes of distress. Emotion-focused coping predicted general distress, but not posttraumatic stress symptom severity. Overall, parents of children surviving a brain tumor appear to be a risk for both posttraumatic stress and general distress. Uncertainty in illness may constitute a primary risk factor for adjustment problems.}, Doi = {10.1207/S15326888CHC3003_1}, Key = {fds272697} } @article{fds72455, Title = {Fuemmeler, B. F., Mullins, L. L, & Marx, B. P. (2001). Posttraumatic stress and general distress among parents of children surviving a brain tumor. Children’s Health Care, 30, 169-182.}, Year = {2001}, Key = {fds72455} } @article{fds72456, Title = {Mullins, L. L., Cote, M. P., Fuemmeler, B. F., Jean, V. M., Beatty, W.W., & Paul, R. H. (2001). Illness intrusiveness, illness uncertainty, and psychological adjustment in individuals with multiple sclerosis. Rehabilitation Psychology, 46, 139-153.}, Year = {2001}, Key = {fds72456} } @article{fds72465, Title = {Fuemmeler BF, Agurs-Collins T, McClernon FJ, Kollins SH, Kail ME, Bergen AW, Ashley-Koch AE. Genes implicated in serotonergic and dopamine functioning interact with gender to predict BMI categories: Findings from a nationally representative sample of young adults. Obesity (in press) }, Key = {fds72465} } @article{fds72466, Title = {McClernon FJ, Fuemmeler BF, Kollins SH, Kail ME, Ashley-Koch AE. Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults. Nicotine & Tobacco Research (in press) }, Key = {fds72466} } @article{fds202522, Title = {Fuemmeler, B. F., Yang, C., Costanzo, P., Hoyle, R.H., Siegler, I.C., Williams, R.B., Ostbye, T. (in press). Parenting styles and BMI trajectories from adolescence into adulthood: A longitudinal study of the Add Health cohort. Health Psychology}, Key = {fds202522} } @article{fds202523, Title = {Ranby, K.W., Boynton, M.H., Kollins, S. H., McClernon, J., Yang, C., & Fuemmeler, B.F. (in press). Understanding the phenotypic structure of ADHD in a US population-based sample. Journal of Clinical Child and Adolescent Psychology. }, Key = {fds202523} } @article{fds211227, Title = {Fuemmeler, B.F., Lovelady, C.A., Zucker, N.L., Ostbye, T. (in press). Parental obesity moderates relationship between childhood appetitive traits and weight. Obesity}, Key = {fds211227} } @article{fds211230, Title = {Fuemmeler, B.F., Pendzich, M.K., Clark, K., Rossoff, P., Blatt, J., Lovelady , C., Demark-Wahnefried, W. (in press). Changes in weight, body composition, diet, and physical activity during the first year of treatment for childhood acute leukemia and lymphoma. Journal of Pediatric Hematology and Oncology }, Key = {fds211230} } @article{fds215514, Title = {Fuemmeler, B.F., Lovelady, C.A., Zucker, N.L., Ostbye, T. (in press). Parental obesity moderates relationship between childhood eating behaviors and weight. Obesity }, Key = {fds215514} } | |
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