Publications of Jessica Leete    :chronological  alphabetical  combined listing:

%% Papers Published   
@article{fds346829,
   Author = {Ahmed, S and Hu, R and Leete, J and Layton, AT},
   Title = {Understanding sex differences in long-term blood pressure
             regulation: insights from experimental studies and
             computational modeling.},
   Journal = {American Journal of Physiology Heart and Circulatory
             Physiology},
   Volume = {316},
   Number = {5},
   Pages = {H1113-H1123},
   Year = {2019},
   Month = {May},
   url = {http://dx.doi.org/10.1152/ajpheart.00035.2019},
   Abstract = {Sex differences in blood pressure and the prevalence of
             hypertension are found in humans and animal models.
             Moreover, there has been a recent explosion of data
             concerning sex differences in nitric oxide, the
             renin-angiotensin-aldosterone system, inflammation, and
             kidney function. These data have the potential to reveal the
             mechanisms underlying male-female differences in blood
             pressure control. To elucidate the interactions among the
             multitude of physiological processes involved, one may apply
             computational models. In this review, we describe published
             computational models that represent key players in blood
             pressure regulation, and highlight sex-specific models and
             their findings.},
   Doi = {10.1152/ajpheart.00035.2019},
   Key = {fds346829}
}

@article{fds339743,
   Author = {Leete, J and Layton, AT},
   Title = {Sex-specific long-term blood pressure regulation: Modeling
             and analysis.},
   Journal = {Computers in Biology and Medicine},
   Volume = {104},
   Pages = {139-148},
   Year = {2019},
   Month = {January},
   url = {http://dx.doi.org/10.1016/j.compbiomed.2018.11.002},
   Abstract = {Hypertension is a global health challenge: it affects one
             billion people worldwide and is estimated to account for
             >60% of all cases or types of cardiovascular disease. In
             part because sex differences in blood pressure regulation
             mechanisms are not sufficiently well understood, fewer
             hypertensive women achieve blood pressure control compared
             to men, even though compliance and treatment rates are
             generally higher in women. Thus, the objective of this study
             is to identify which factors contribute to the sexual
             dimorphism in response to anti-hypertensive therapies
             targeting the renin angiotensin system (RAS). To accomplish
             that goal, we develop sex-specific blood pressure regulation
             models. Sex differences in the RAS, baseline adosterone
             level, and the reactivity of renal sympathetic nervous
             activity (RSNA) are represented. A novel aspect of the model
             is the representation of sex-specific vasodilatory effect of
             the bound angiotensin II type two receptor (AT2R-bound Ang
             II) on renal vascular resistance. Model simulations suggest
             that sex differences in RSNA are the largest cause of female
             resistance to developing hypertension due to the direct
             influence of RSNA on afferent arteriole resistance.
             Furthermore, the model predicts that the sex-specific
             vasodilatory effects of AT2R-bound Ang II on renal vascular
             resistance may explain the higher effectiveness of
             angiotensin receptor blockers in treating hypertensive women
             (but not men), compared to angiotensin converting enzyme
             inhibitors.},
   Doi = {10.1016/j.compbiomed.2018.11.002},
   Key = {fds339743}
}

@article{fds346830,
   Author = {Leete, J and Gurley, S and Layton, A},
   Title = {Modeling Sex Differences in the Renin Angiotensin System and
             the Efficacy of Antihypertensive Therapies.},
   Journal = {Computers & Chemical Engineering},
   Volume = {112},
   Pages = {253-264},
   Year = {2018},
   Month = {April},
   url = {http://dx.doi.org/10.1016/j.compchemeng.2018.02.009},
   Abstract = {The renin angiotensin system is a major regulator of blood
             pressure and a target for many anti-hypertensive therapies;
             yet the efficacy of these treatments varies between the
             sexes. We use published data for systemic RAS hormones to
             build separate models for four groups of rats: male
             normotensive, male hypertensive, female normotensive, and
             female hypertensive rats. We found that plasma renin
             activity, angiotensinogen production rate, angiotensin
             converting enzyme activity, and neutral endopeptidase
             activity differ significantly among the four groups of rats.
             Model results indicate that angiotensin converting enzyme
             inhibitors and angiotensin receptor blockers induce similar
             percentage decreases in angiotensin I and II between groups,
             but substantially different absolute decreases. We further
             propose that a major difference between the male and female
             RAS may be the strength of the feedback mechanism, by which
             receptor bound angiotensin II impacts the production of
             renin.},
   Doi = {10.1016/j.compchemeng.2018.02.009},
   Key = {fds346830}
}