Papers Published

1. MM Haglund, WL Stahl, DD Kunkel, PA Schwartzkroin, Developmental and regional differences in the localization of Na,K-ATPase activity in the rabbit hippocampus., Brain research, NETHERLANDS, vol. 343 no. 1 (September, 1985), pp. 198-203, ISSN 0006-8993
   (last updated on 2007/03/17)

   Abstract:
   Regional differences in Na,K-ATPase activity, and development of Na,K-ATPase activity were examined in rabbit hippocampus using a histochemical marker of enzyme activity. Stratum lucidum of CA3/CA2, corresponding to the mossy fiber terminal field, showed high Na,K-ATPase activity compared to stratum radiatum of CA1. A significant increase in Na,K-ATPase activity was found between 8 and 15 days postnatal. Tissues with limited Na,K-ATPase activity (immature hippocampus, the mature CA1 region) appear particularly prone to seizure-like abnormalities, perhaps reflecting an inability to regulate extracellular potassium.

   Keywords:
   Animals • Hippocampus • Histocytochemistry • Na(+)-K(+)-Exchanging ATPase • Rabbits • enzymology* • metabolism*