Scott H. Kollins
Publications [#274103] of Scott H. Kollins
- Kozink, RV; Kollins, SH; McClernon, FJ, Smoking withdrawal modulates right inferior frontal cortex but not presupplementary motor area activation during inhibitory control.,
Neuropsychopharmacology, vol. 35 no. 13
pp. 2600-2606, ISSN 1740-634X , [doi]
(last updated on 2019/12/08)
Smokers exhibit decrements in inhibitory control (IC) during withdrawal. The objective of this study was to investigate the neural basis of these effects in critical substrates of IC--right inferior frontal cortex (rIFC) and presupplementary motor area (pre-SMA). Smokers were scanned following smoking as usual and after 24-h smoking abstinence. During scanning they completed a Go/No-Go task that required inhibiting responses to infrequent STOP trials. Event-related brain activation in response to successfully inhibited STOP trials was evaluated in two regions of interest: rIFC (10 mm sphere, x=40, y=30, z=26) and pre-SMA (10 mm sphere, x=2, y=18, z=40). Smoking abstinence robustly increased errors of commission on STOP trials (37.1 vs 24.8% in the satiated condition, p<0.001) while having no effects on GO trial accuracy or reaction time (RT). In rIFC, smoking abstinence was associated with a significantly increased event-related BOLD signal (p=0.026). Pre-SMA was unaffected by smoking condition. The results of this preliminary study suggest that successful IC during withdrawal is associated with increased processing demands on a cortical center associated with attention to inhibitory signals.
Adult • Female • Frontal Lobe • Humans • Inhibition (Psychology)* • Magnetic Resonance Imaging • Male • Motor Cortex • Psychomotor Performance • Reaction Time • Substance Withdrawal Syndrome • Tobacco Use Disorder • methods • physiology • physiology* • physiopathology*