Scott H. Kollins
Publications [#274112] of Scott H. Kollins
- Rush, CR; Kollins, SH; Pazzaglia, PJ, Discriminative-stimulus and participant-rated effects of methylphenidate, bupropion, and triazolam in d-amphetamine-trained humans.,
Experimental and Clinical Psychopharmacology, vol. 6 no. 1
pp. 32-44, ISSN 1064-1297 , [doi]
(last updated on 2019/12/14)
The discriminative-stimulus and participate-rated effects of a range of doses of d-amphetamine (2.5-20 mg), methylphenidate (5-40 mg), bupropion (50-400 mg), and triazolam (0.0625-0.5 mg) were tested in 5 humans trained to discriminate between oral d-amphetamine (20 mg) and placebo. d-Amphetamine and methylphenidate generally dose dependently increased drug-appropriate responding. Bupropion and triazolam on average occasioned less than or equal to 40% drug-appropriate responding. d-Amphetamine, methylphenidate, and bupropion produced stimulant-like participant-rated effects, while triazolam produced sedative-like effects. These results further demonstrate that the acute behavioral effects of d-amphetamine and methylphenidate overlap extensively in humans, which is concordant with preclinical studies. Bupropion produced some d-amphetamine-like, participant-rated drug effects but did not occasion significant levels of d-amphetamine-appropriate responding. These findings are concordant with previous findings of a dissociation between the discriminative-stimulus and participant-rated effects of drugs.
Adult • Affect • Blood Pressure • Bupropion • Dextroamphetamine • Discrimination (Psychology) • Dopamine Uptake Inhibitors • Female • GABA Modulators • Heart Rate • Humans • Male • Methylphenidate • Middle Aged • Psychomotor Performance • Triazolam • drug effects • drug effects* • pharmacology*