Publications [#157972] of Li-Tzy Wu
- AA Patkar, P Mannelli, K Peindl, KP Hill, LT Wu, T Lee, C Kuhn, Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence.,
Journal of psychiatric research, vol. 42 no. 14
pp. 1213-9, ISSN 0022-3956 [doi]
(last updated on 2013/06/01)
BACKGROUND: Preclinical evidence indicates that exposure to cocaine influences the activity of the serotonin transporter (5-HTT) as well as several 5-HT receptor subtypes. However, little is known about the relationship between the 5-HTT and 5-HT receptors following cocaine exposure in humans. OBJECTIVE: We examined the relationship between platelet 5-HTT, a presynaptic 5-HT measure, and prolactin (PRL) response to meta-chlorophenylpiperazine (m-CPP), a postsynaptic 5-HT receptor agonist in cocaine dependent individuals. METHODS: Platelet [3H] paroxetine binding sites were assayed and the m-CPP challenge test was performed in 35 African American cocaine dependent individuals and 33 controls. Clinical measures included assessments of drug use severity and depression. RESULTS: Cocaine subjects showed reduced Bmax of [3H] paroxetine (t=4.67, p<0.01) and blunted PRL response to m-CPP (F=21.86, p<0.01) compared to controls. There was a positive correlation between Bmax and delta PRL [peak-baseline PRL] in cocaine subjects (r=0.50, p<0.01) but not in controls (r=0.19). ANCOVA analyses showed that the cocaine subgroup with moderate and severe reduction in Bmax showed a greater blunting in PRL response compared to the subgroup with mild Bmax reductions (F=9.44, p<.005). Multivariate regression models showed that the main effects as well as the interaction of Bmax and severity of cocaine use significantly contributed to impaired PRL response (F=17.90, p<.001). CONCLUSIONS: Disturbances in serotonin transporter binding and post-synaptic 5-HT receptor function seem to be associated in cocaine-dependent subjects. Severity of cocaine use appears to mediate this relationship. Whether there is a causal association between the two measures, or cocaine has separate and independent pre- and post-synaptic effects needs to be clarified.
African Americans • Binding Sites • Binding, Competitive • Blood Platelets • Cocaine-Related Disorders • Female • Humans • Male • Multivariate Analysis • Paroxetine • Piperazines • Prolactin • Radioimmunoassay • Radioligand Assay • Regression Analysis • Serotonin • Serotonin Plasma Membrane Transport Proteins • Serotonin Receptor Agonists • Severity of Illness Index • Tritium • blood • blood* • drug effects • drug effects* • ethnology • metabolism • pharmacology • pharmacology* • physiopathology* • statistics & numerical data