Publications [#157979] of Li-Tzy Wu
- LT Wu, DG Blazer, AA Patkar, ML Stitzer, PG Wakim, RK Brooner, Heterogeneity of stimulant dependence: a national drug abuse treatment clinical trials network study.,
The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions, vol. 18 no. 3
pp. 206-18, ISSN 1521-0391 [doi]
(last updated on 2013/06/01)
We investigated the presence of DSM-IV subtyping for dependence on cocaine and amphetamines (with versus without physical dependence) among outpatient stimulant users enrolled in a multisite study of the Clinical Trials Network (CTN). Three mutually exclusive groups were identified: primary cocaine users (n = 287), primary amphetamine users (n = 99), and dual users (cocaine and amphetamines; n = 29). Distinct subtypes were examined with latent class and logistic regression procedures. Cocaine users were distinct from amphetamine users in age and race/ethnicity. There were four distinct classes of primary cocaine users: non-dependence (15%), compulsive use (14%), tolerance and compulsive use (15%), and physiological dependence (tolerance, withdrawal, and compulsive use; 56%). Three distinct classes of primary amphetamine users were identified: non-dependence (11%), intermediate physiological dependence (31%), and physiological dependence (58%). Regardless of stimulants used, most female users were in the most severe or the physiological dependence group. These results lend support for subtyping dependence in the emerging DSM-V.
Adult • Age Factors • Amphetamine-Related Disorders • Cocaine-Related Disorders • Comorbidity • Diagnostic and Statistical Manual of Mental Disorders • Drug Tolerance • Female • Humans • Male • Models, Psychological • Severity of Illness Index • Sex Distribution • Substance Withdrawal Syndrome • classification • classification* • diagnosis • diagnosis* • epidemiology